Wnt10b (wingless-type MMTV integration site family, member 10B) - Rat Genome Database

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Gene: Wnt10b (wingless-type MMTV integration site family, member 10B) Mus musculus
Analyze
Symbol: Wnt10b
Name: wingless-type MMTV integration site family, member 10B
RGD ID: 1312745
MGI Page MGI
Description: Predicted to enable cytokine activity and frizzled binding activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and regulation of DNA-templated transcription. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including genitourinary system; integumental system; nervous system; surface ectoderm; and tooth. Human ortholog(s) of this gene implicated in obesity; split hand-foot malformation 6; and tooth agenesis. Orthologous to human WNT10B (Wnt family member 10B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: protein Wnt-10b; wingless related MMTV integration site 10b; wnt-12; Wnt1; Wnt12
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,668,593 - 98,676,093 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1598,668,593 - 98,676,031 (-)EnsemblGRCm39 Ensembl
GRCm381598,770,712 - 98,778,206 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,770,712 - 98,778,150 (-)EnsemblGRCm38mm10GRCm38
MGSCv371598,602,183 - 98,608,581 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361598,599,796 - 98,606,184 (-)NCBIMGSCv36mm8
Celera15100,921,391 - 100,927,785 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (ISO)
diosgenin  (EXP)
dorsomorphin  (ISO)
fenvalerate  (ISO)
genistein  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
linoleic acid  (EXP)
manganese(II) chloride  (ISO)
mercaptopurine  (ISO)
methotrexate  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
O-methyleugenol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenothrin  (ISO)
purine-6-thiol  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium fluoride  (EXP,ISO)
sotorasib  (ISO)
tamoxifen  (ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
valproic acid  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (TAS)
bone trabecula formation  (IMP)
canonical Wnt signaling pathway  (IBA,IDA,ISO)
cell fate commitment  (IBA)
cell population proliferation  (IDA)
cell-cell signaling  (TAS)
cellular response to cAMP  (IDA)
cellular response to hydrostatic pressure  (ISO)
cellular response to organic cyclic compound  (IDA)
cellular response to organic substance  (IDA)
cellular response to parathyroid hormone stimulus  (IDA)
chondrocyte differentiation  (ISO)
epithelial cell differentiation  (IDA)
fat cell differentiation  (IDA)
fungiform papilla development  (IMP)
G2/M transition of mitotic cell cycle  (IGI)
hematopoietic stem cell proliferation  (IDA,ISO)
lipid metabolic process  (IMP)
myoblast development  (IMP)
myoblast differentiation involved in skeletal muscle regeneration  (IMP)
negative regulation of cold-induced thermogenesis  (IMP)
negative regulation of epithelial cell proliferation  (IDA)
negative regulation of fat cell differentiation  (IDA,ISO)
negative regulation of transcription by RNA polymerase II  (IDA)
neuron differentiation  (IBA)
osteoblast differentiation  (IDA)
positive regulation of apoptotic process  (ISO)
positive regulation of bone mineralization  (IDA)
positive regulation of canonical Wnt signaling pathway  (IDA)
positive regulation of DNA-binding transcription factor activity  (IDA)
positive regulation of epithelial cell differentiation  (IDA)
positive regulation of G2/M transition of mitotic cell cycle  (IDA)
positive regulation of hematopoietic stem cell proliferation  (IDA)
positive regulation of ossification  (IGI,IMP)
positive regulation of osteoblast differentiation  (IDA)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (IDA)
positive regulation of T cell differentiation  (IDA)
positive regulation of timing of anagen  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA,IMP)
protein stabilization  (ISO)
regulation of cell cycle  (IDA)
regulation of fat cell differentiation  (IMP)
regulation of proteasomal ubiquitin-dependent protein catabolic process  (IDA,IMP)
regulation of protein metabolic process  (IMP)
regulation of skeletal muscle tissue development  (IMP)
regulation of transcription by RNA polymerase II  (IDA)
sensory perception of taste  (IMP)
signal transduction  (TAS)
skeletal muscle fiber development  (IMP)
skeletal muscle tissue regeneration  (IMP)
smoothened signaling pathway  (IDA)
T cell differentiation  (IDA)
transcription by RNA polymerase II  (IMP)
Wnt signaling pathway  (IGI)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Ectopic expression of Wnt10b decreases adiposity and improves glucose homeostasis in obese rats. Aslanidi G, etal., Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E726-36. Epub 2007 Jun 19.
2. WNT10B mutations in human obesity. Christodoulides C, etal., Diabetologia. 2006 Apr;49(4):678-84. Epub 2006 Feb 14.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
12. Alternative wnt signaling is initiated by distinct receptors. van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
Additional References at PubMed
PMID:3027377   PMID:7490102   PMID:7547479   PMID:7892260   PMID:7896292   PMID:8682303   PMID:8875992   PMID:9160667   PMID:9362463   PMID:9393971   PMID:9434954   PMID:9441749  
PMID:9768360   PMID:9769173   PMID:9889131   PMID:10349636   PMID:10415363   PMID:10937998   PMID:11023871   PMID:11042159   PMID:11044393   PMID:11076861   PMID:11092808   PMID:11217851  
PMID:11429295   PMID:11520664   PMID:11914369   PMID:12015971   PMID:12055200   PMID:12379851   PMID:12477932   PMID:12591239   PMID:12668638   PMID:12702652   PMID:12815618   PMID:14681479  
PMID:14688221   PMID:14699584   PMID:14745960   PMID:14960276   PMID:15044261   PMID:15136142   PMID:15190075   PMID:15342465   PMID:15673614   PMID:15684380   PMID:15728361   PMID:15778975  
PMID:15880404   PMID:16140987   PMID:16141072   PMID:16141073   PMID:16222716   PMID:16469292   PMID:16510119   PMID:16510873   PMID:16524929   PMID:16678101   PMID:16720875   PMID:16738056  
PMID:16809539   PMID:16813524   PMID:17071745   PMID:17121988   PMID:17128274   PMID:17199044   PMID:17284610   PMID:17397822   PMID:17487458   PMID:17548054   PMID:17708715   PMID:17804636  
PMID:17943183   PMID:18022614   PMID:18045882   PMID:18155657   PMID:18256193   PMID:18287559   PMID:18308947   PMID:18351662   PMID:18351675   PMID:18364260   PMID:18465804   PMID:18480165  
PMID:18635608   PMID:18676816   PMID:18800919   PMID:18957421   PMID:18991257   PMID:19056892   PMID:19075223   PMID:19141668   PMID:19164599   PMID:19165927   PMID:19185060   PMID:19282366  
PMID:19487454   PMID:19562671   PMID:19598129   PMID:19619491   PMID:19723499   PMID:19806668   PMID:20041157   PMID:20143239   PMID:20499361   PMID:20595636   PMID:20940229   PMID:21041481  
PMID:21246616   PMID:21267068   PMID:21531785   PMID:21566665   PMID:21600200   PMID:21655085   PMID:21663957   PMID:21677750   PMID:21784065   PMID:21872687   PMID:21873635   PMID:21905163  
PMID:21936019   PMID:21999426   PMID:22024319   PMID:22234613   PMID:22277947   PMID:22342532   PMID:22365545   PMID:22393015   PMID:22434869   PMID:22451941   PMID:22509524   PMID:22832493  
PMID:22833125   PMID:22898663   PMID:22955916   PMID:22956684   PMID:23190887   PMID:23201222   PMID:23274346   PMID:23293290   PMID:23307470   PMID:23315474   PMID:23431057   PMID:23569433  
PMID:23603388   PMID:23861379   PMID:23884445   PMID:23900840   PMID:23916705   PMID:24194600   PMID:24394376   PMID:24586192   PMID:24664975   PMID:24750467   PMID:24936779   PMID:24952961  
PMID:25104077   PMID:25249463   PMID:25428587   PMID:26056007   PMID:26338900   PMID:26436894   PMID:26459221   PMID:26581094   PMID:26685160   PMID:26702830   PMID:27032939   PMID:27055562  
PMID:27295344   PMID:27321946   PMID:27362799   PMID:27414999   PMID:27621364   PMID:27626380   PMID:27864382   PMID:27922003   PMID:28506989   PMID:28683327   PMID:28698625   PMID:28715412  
PMID:28800644   PMID:28813421   PMID:29688375   PMID:30149605   PMID:30220568   PMID:30228991   PMID:30525243   PMID:30563890   PMID:30791955   PMID:30940800   PMID:31220272   PMID:31433978  
PMID:32290615   PMID:32439755   PMID:32968282   PMID:33135480   PMID:33141892   PMID:33338666   PMID:34108685   PMID:34449628   PMID:34590686   PMID:35333176   PMID:35831952   PMID:36305473  


Genomics

Comparative Map Data
Wnt10b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,668,593 - 98,676,093 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1598,668,593 - 98,676,031 (-)EnsemblGRCm39 Ensembl
GRCm381598,770,712 - 98,778,206 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,770,712 - 98,778,150 (-)EnsemblGRCm38mm10GRCm38
MGSCv371598,602,183 - 98,608,581 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361598,599,796 - 98,606,184 (-)NCBIMGSCv36mm8
Celera15100,921,391 - 100,927,785 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.65NCBI
WNT10B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381248,965,340 - 48,971,735 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1248,965,340 - 48,971,735 (-)EnsemblGRCh38hg38GRCh38
GRCh371249,359,123 - 49,365,518 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,645,390 - 47,651,810 (-)NCBINCBI36Build 36hg18NCBI36
Build 341247,645,390 - 47,651,810NCBI
Celera1248,153,932 - 48,160,449 (-)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1246,390,715 - 46,397,232 (-)NCBIHuRef
CHM1_11249,324,923 - 49,331,441 (-)NCBICHM1_1
T2T-CHM13v2.01248,927,542 - 48,933,936 (-)NCBIT2T-CHM13v2.0
Wnt10b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27129,922,088 - 129,927,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,922,088 - 129,927,892 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,729,217 - 131,735,022 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07133,954,768 - 133,960,573 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07133,867,281 - 133,873,087 (-)NCBIRnor_WKY
Rnor_6.07140,448,284 - 140,466,159 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,448,465 - 140,454,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,958,456 - 114,976,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,541,197 - 137,547,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17137,617,649 - 137,623,456 (-)NCBI
Celera7126,411,054 - 126,416,855 (-)NCBICelera
Cytogenetic Map7q36NCBI
Wnt10b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555007,782,782 - 7,788,309 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555007,782,782 - 7,800,281 (-)NCBIChiLan1.0ChiLan1.0
WNT10B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11240,659,106 - 40,665,734 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,659,106 - 40,665,734 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01239,771,163 - 39,785,411 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
WNT10B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,599,905 - 5,605,506 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,601,089 - 5,605,501 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2740,652,204 - 40,660,691 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0275,648,026 - 5,656,510 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,650,675 - 5,656,505 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,611,949 - 5,620,434 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,602,160 - 5,610,644 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,044,507 - 41,052,994 (-)NCBIUU_Cfam_GSD_1.0
Wnt10b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,386,524 - 66,396,592 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365126,768,240 - 6,774,172 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365126,768,240 - 6,774,172 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT10B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl514,997,381 - 15,003,567 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1514,997,377 - 15,013,928 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,407,596 - 15,422,005 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT10B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,205,728 - 45,229,050 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,205,566 - 45,210,893 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037200,931,714 - 200,938,206 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt10b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248163,210,828 - 3,227,096 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248163,221,573 - 3,227,102 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:410
Count of miRNA genes:241
Interacting mature miRNAs:270
Transcripts:ENSMUST00000023732, ENSMUST00000166022
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156481182698811946Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82615474104073951Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585896437104073951Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585896437104073951Mouse
1357614Bmca_mbile mucin accumulation (mouse)Not determined1585896437104073951Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585901546104073951Mouse
4141581Dshv1_mdorsal hippocampal volume 1 (mouse)Not determined92788640103425899Mouse
14700689Carg5_mCandida albicans resistance gene 5 (mouse)1597697881103008427Mouse
11528547Sluc34_msusceptibility to lung cancer 34 (mouse)1597884933102896555Mouse

Markers in Region
Wnt10b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381598,771,920 - 98,772,454UniSTSGRCm38
MGSCv371598,602,351 - 98,602,885UniSTSGRCm37
Celera15100,921,559 - 100,922,093UniSTS
Cytogenetic Map15F1UniSTS
cM Map1556.8UniSTS
cM Map1556.8UniSTS
AF029307  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381598,775,758 - 98,775,843UniSTSGRCm38
MGSCv371598,606,189 - 98,606,274UniSTSGRCm37
Celera15100,925,393 - 100,925,478UniSTS
Cytogenetic Map15F1UniSTS
cM Map1556.8UniSTS
Whitehead/MRC_RH15875.57UniSTS
U30464  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381598,772,180 - 98,772,336UniSTSGRCm38
MGSCv371598,602,611 - 98,602,767UniSTSGRCm37
Celera15100,921,819 - 100,921,975UniSTS
Cytogenetic Map15F1UniSTS
cM Map1556.8UniSTS
Whitehead/MRC_RH15875.67UniSTS
Whitehead_YAC15 UniSTS
Wnt10b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15F1UniSTS
Wnt10b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381598,771,833 - 98,772,393UniSTSGRCm38
MGSCv371598,602,264 - 98,602,824UniSTSGRCm37
Celera15100,921,472 - 100,922,032UniSTS
Cytogenetic Map15F1UniSTS
Wnt10b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381598,771,883 - 98,772,143UniSTSGRCm38
MGSCv371598,602,314 - 98,602,574UniSTSGRCm37
Celera15100,921,522 - 100,921,782UniSTS
Cytogenetic Map15F1UniSTS
Wnt10b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15F1UniSTS
Wnt10b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15F1UniSTS
Wnt10b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381598,772,904 - 98,774,210UniSTSGRCm38
MGSCv371598,603,335 - 98,604,641UniSTSGRCm37
Celera15100,922,543 - 100,923,847UniSTS
Cytogenetic Map15F1UniSTS
Wnt10b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381598,772,467 - 98,772,790UniSTSGRCm38
MGSCv371598,602,898 - 98,603,221UniSTSGRCm37
Celera15100,922,106 - 100,922,429UniSTS
Cytogenetic Map15F1UniSTS
U30464  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381598,772,027 - 98,772,132UniSTSGRCm38
MGSCv371598,602,458 - 98,602,563UniSTSGRCm37
Celera15100,921,666 - 100,921,771UniSTS
Cytogenetic Map15F1UniSTS
Whitehead/MRC_RH15875.67UniSTS
Wnt10b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381598,776,548 - 98,776,973UniSTSGRCm38
MGSCv371598,606,979 - 98,607,404UniSTSGRCm37
Celera15100,926,183 - 100,926,608UniSTS
Cytogenetic Map15F1UniSTS
cM Map1556.8UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000023732   ⟹   ENSMUSP00000023732
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1598,669,634 - 98,676,031 (-)Ensembl
GRCm38.p6 Ensembl1598,771,753 - 98,778,150 (-)Ensembl
RefSeq Acc Id: ENSMUST00000166022   ⟹   ENSMUSP00000131056
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1598,670,081 - 98,675,142 (-)Ensembl
GRCm38.p6 Ensembl1598,772,200 - 98,777,261 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226610   ⟹   ENSMUSP00000153817
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1598,669,641 - 98,676,031 (-)Ensembl
GRCm38.p6 Ensembl1598,771,760 - 98,778,150 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226655   ⟹   ENSMUSP00000154384
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1598,669,833 - 98,676,007 (-)Ensembl
GRCm38.p6 Ensembl1598,771,952 - 98,778,126 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226846   ⟹   ENSMUSP00000154513
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1598,670,101 - 98,674,910 (-)Ensembl
GRCm38.p6 Ensembl1598,772,220 - 98,777,029 (-)Ensembl
RefSeq Acc Id: ENSMUST00000228546   ⟹   ENSMUSP00000154394
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1598,668,593 - 98,676,024 (-)Ensembl
GRCm38.p6 Ensembl1598,770,712 - 98,778,143 (-)Ensembl
RefSeq Acc Id: ENSMUST00000228594   ⟹   ENSMUSP00000153930
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1598,670,083 - 98,674,910 (-)Ensembl
GRCm38.p6 Ensembl1598,772,202 - 98,777,029 (-)Ensembl
RefSeq Acc Id: NM_011718   ⟹   NP_035848
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391598,669,633 - 98,676,031 (-)NCBI
GRCm381598,771,752 - 98,778,150 (-)NCBI
MGSCv371598,602,183 - 98,608,581 (-)RGD
Celera15100,921,391 - 100,927,785 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006520891   ⟹   XP_006520954
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391598,668,593 - 98,675,231 (-)NCBI
GRCm381598,770,712 - 98,777,353 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006520892   ⟹   XP_006520955
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391598,668,593 - 98,676,093 (-)NCBI
GRCm381598,770,712 - 98,778,206 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006520893   ⟹   XP_006520956
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391598,668,593 - 98,675,221 (-)NCBI
GRCm381598,770,712 - 98,777,340 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035848   ⟸   NM_011718
- Peptide Label: precursor
- UniProtKB: P70702 (UniProtKB/Swiss-Prot),   P48614 (UniProtKB/Swiss-Prot),   Q1RME7 (UniProtKB/TrEMBL),   A0A6P5RAQ1 (UniProtKB/TrEMBL),   A0A8C6G6V9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006520955   ⟸   XM_006520892
- Peptide Label: isoform X2
- UniProtKB: P48614 (UniProtKB/Swiss-Prot),   A0A6P5R5B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006520954   ⟸   XM_006520891
- Peptide Label: isoform X1
- UniProtKB: P70702 (UniProtKB/Swiss-Prot),   P48614 (UniProtKB/Swiss-Prot),   A0A6P5RAQ1 (UniProtKB/TrEMBL),   A0A8C6G6V9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006520956   ⟸   XM_006520893
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSMUSP00000131056   ⟸   ENSMUST00000166022
RefSeq Acc Id: ENSMUSP00000153817   ⟸   ENSMUST00000226610
RefSeq Acc Id: ENSMUSP00000154513   ⟸   ENSMUST00000226846
RefSeq Acc Id: ENSMUSP00000154384   ⟸   ENSMUST00000226655
RefSeq Acc Id: ENSMUSP00000023732   ⟸   ENSMUST00000023732
RefSeq Acc Id: ENSMUSP00000154394   ⟸   ENSMUST00000228546
RefSeq Acc Id: ENSMUSP00000153930   ⟸   ENSMUST00000228594

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48614-F1-model_v2 AlphaFold P48614 1-389 view protein structure

Promoters
RGD ID:6826605
Promoter ID:MM_KWN:19637
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:ENSMUST00000088289,   UC007XNS.1,   UC007XNT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361598,606,796 - 98,607,296 (-)MPROMDB
RGD ID:8684936
Promoter ID:EPDNEW_M20499
Type:multiple initiation site
Name:Wnt10b_1
Description:Mus musculus wingless-type MMTV integration site family, member10B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381598,778,126 - 98,778,186EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108061 AgrOrtholog
Ensembl Genes ENSMUSG00000022996 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000023732 ENTREZGENE
  ENSMUSP00000023732.6 UniProtKB/Swiss-Prot
  ENSMUSP00000131056.2 UniProtKB/Swiss-Prot
  ENSMUSP00000153817.2 UniProtKB/Swiss-Prot
  ENSMUSP00000153930.2 UniProtKB/Swiss-Prot
  ENSMUSP00000154384.2 UniProtKB/TrEMBL
  ENSMUSP00000154394.2 UniProtKB/TrEMBL
  ENSMUSP00000154513 ENTREZGENE
  ENSMUSP00000154513.2 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023732 ENTREZGENE
  ENSMUST00000023732.12 UniProtKB/Swiss-Prot
  ENSMUST00000166022.2 UniProtKB/Swiss-Prot
  ENSMUST00000226610.2 UniProtKB/Swiss-Prot
  ENSMUST00000226655.2 UniProtKB/TrEMBL
  ENSMUST00000226846 ENTREZGENE
  ENSMUST00000226846.2 UniProtKB/Swiss-Prot
  ENSMUST00000228546.2 UniProtKB/TrEMBL
  ENSMUST00000228594.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.2460.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Wnt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108061 ENTREZGENE
NCBI Gene 22410 ENTREZGENE
PANTHER PROTEIN WNT-10B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam wnt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wnt10b PhenoGen
PRINTS WNT10PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WNT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2I3BQZ8_MOUSE UniProtKB/TrEMBL
  A0A6P5R5B0 ENTREZGENE
  A0A6P5RAQ1 ENTREZGENE
  A0A8C6G6V9 ENTREZGENE
  P48614 ENTREZGENE
  P70702 ENTREZGENE
  Q1RME7 ENTREZGENE, UniProtKB/TrEMBL
  Q71V74_MOUSE UniProtKB/TrEMBL
  WN10B_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P70702 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-01 Wnt10b  wingless-type MMTV integration site family, member 10B    wingless related MMTV integration site 10b  Symbol and/or name change 5135510 APPROVED