WNT10B (Wnt family member 10B) - Rat Genome Database

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Pathways
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Gene: WNT10B (Wnt family member 10B) Pan paniscus
Analyze
Symbol: WNT10B
Name: Wnt family member 10B
RGD ID: 12046529
Description: ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); signaling receptor binding (inferred); INVOLVED IN bone trabecula formation (ortholog); canonical Wnt signaling pathway (ortholog); cell population proliferation (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); genetic disease (ortholog); Neoplasm Recurrence, Local (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21045,205,454 - 45,219,702 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11245,202,215 - 45,216,463 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01239,771,163 - 39,785,411 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11240,659,106 - 40,665,734 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,659,106 - 40,665,734 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
bone trabecula formation  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell fate commitment  (IEA)
cell population proliferation  (IEA,ISO)
cellular response to cAMP  (IEA,ISO)
cellular response to hydrostatic pressure  (ISO)
cellular response to organic cyclic compound  (IEA,ISO)
cellular response to organic substance  (IEA,ISO)
cellular response to parathyroid hormone stimulus  (IEA,ISO)
chondrocyte differentiation  (IEA)
epithelial cell differentiation  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
fungiform papilla development  (IEA,ISO)
G2/M transition of mitotic cell cycle  (IEA,ISO)
hematopoietic stem cell proliferation  (IEA,ISO)
lipid metabolic process  (IEA,ISO)
myoblast development  (IEA,ISO)
myoblast differentiation involved in skeletal muscle regeneration  (IEA,ISO)
negative regulation of cold-induced thermogenesis  (IEA)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neuron differentiation  (IEA)
osteoblast differentiation  (IEA,ISO)
positive regulation of apoptotic process  (IEA)
positive regulation of bone mineralization  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of epithelial cell differentiation  (IEA,ISO)
positive regulation of G2/M transition of mitotic cell cycle  (IEA,ISO)
positive regulation of hematopoietic stem cell proliferation  (IEA,ISO)
positive regulation of ossification  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (IEA,ISO)
positive regulation of T cell differentiation  (IEA,ISO)
positive regulation of timing of anagen  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
protein stabilization  (IEA)
regulation of cell cycle  (IEA,ISO)
regulation of fat cell differentiation  (IEA,ISO)
regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
regulation of protein metabolic process  (IEA,ISO)
regulation of skeletal muscle tissue development  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
sensory perception of taste  (IEA,ISO)
skeletal muscle fiber development  (IEA,ISO)
skeletal muscle tissue regeneration  (IEA,ISO)
smoothened signaling pathway  (IEA,ISO)
T cell differentiation  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
Wnt signaling pathway  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
WNT10B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21045,205,454 - 45,219,702 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11245,202,215 - 45,216,463 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01239,771,163 - 39,785,411 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11240,659,106 - 40,665,734 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,659,106 - 40,665,734 (+)Ensemblpanpan1.1panPan2
WNT10B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381248,965,340 - 48,971,735 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1248,965,340 - 48,971,735 (-)EnsemblGRCh38hg38GRCh38
GRCh371249,359,123 - 49,365,518 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,645,390 - 47,651,810 (-)NCBINCBI36Build 36hg18NCBI36
Build 341247,645,390 - 47,651,810NCBI
Celera1248,153,932 - 48,160,449 (-)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1246,390,715 - 46,397,232 (-)NCBIHuRef
CHM1_11249,324,923 - 49,331,441 (-)NCBICHM1_1
T2T-CHM13v2.01248,927,542 - 48,933,936 (-)NCBIT2T-CHM13v2.0
Wnt10b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,668,593 - 98,676,093 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1598,668,593 - 98,676,031 (-)EnsemblGRCm39 Ensembl
GRCm381598,770,712 - 98,778,206 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,770,712 - 98,778,150 (-)EnsemblGRCm38mm10GRCm38
MGSCv371598,602,183 - 98,608,581 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361598,599,796 - 98,606,184 (-)NCBIMGSCv36mm8
Celera15100,921,391 - 100,927,785 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.65NCBI
Wnt10b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,801,046 - 131,806,850 (-)NCBIGRCr8
mRatBN7.27129,922,088 - 129,927,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,922,088 - 129,927,892 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,729,217 - 131,735,022 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,954,768 - 133,960,573 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,867,281 - 133,873,087 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,448,284 - 140,466,159 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,448,465 - 140,454,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,958,456 - 114,976,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,541,197 - 137,547,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17137,617,649 - 137,623,456 (-)NCBI
Celera7126,411,054 - 126,416,855 (-)NCBICelera
Cytogenetic Map7q36NCBI
Wnt10b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555007,782,782 - 7,788,309 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555007,782,782 - 7,800,281 (-)NCBIChiLan1.0ChiLan1.0
WNT10B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,599,905 - 5,605,506 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,601,089 - 5,605,501 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2740,652,204 - 40,660,691 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0275,648,026 - 5,656,510 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,650,675 - 5,656,505 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,611,949 - 5,620,434 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,602,160 - 5,610,644 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,044,507 - 41,052,994 (-)NCBIUU_Cfam_GSD_1.0
Wnt10b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,386,524 - 66,396,592 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365126,768,240 - 6,774,172 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365126,768,240 - 6,774,172 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT10B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl514,997,381 - 15,003,567 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1514,997,377 - 15,013,928 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,407,596 - 15,422,005 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT10B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,205,728 - 45,229,050 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,205,566 - 45,210,893 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037200,931,714 - 200,938,206 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt10b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248163,210,828 - 3,227,096 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248163,221,573 - 3,227,102 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000047668   ⟹   ENSPPAP00000024842
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1240,659,106 - 40,665,734 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000047673   ⟹   ENSPPAP00000024847
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1240,660,451 - 40,664,527 (+)Ensembl
RefSeq Acc Id: XM_003825819   ⟹   XP_003825867
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21045,205,454 - 45,219,702 (+)NCBI
NHGRI_mPanPan11245,202,215 - 45,216,463 (+)NCBI
Mhudiblu_PPA_v01239,771,163 - 39,785,411 (+)NCBI
PanPan1.11240,659,106 - 40,665,734 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034935942   ⟹   XP_034791833
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21045,205,454 - 45,219,702 (+)NCBI
NHGRI_mPanPan11245,202,215 - 45,216,463 (+)NCBI
Mhudiblu_PPA_v01239,771,163 - 39,785,411 (+)NCBI
RefSeq Acc Id: XM_034935943   ⟹   XP_034791834
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21045,205,454 - 45,219,702 (+)NCBI
NHGRI_mPanPan11245,202,215 - 45,216,463 (+)NCBI
Mhudiblu_PPA_v01239,771,163 - 39,785,411 (+)NCBI
RefSeq Acc Id: XM_034935944   ⟹   XP_034791835
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21045,205,454 - 45,219,702 (+)NCBI
NHGRI_mPanPan11245,202,215 - 45,216,463 (+)NCBI
Mhudiblu_PPA_v01239,771,163 - 39,785,411 (+)NCBI
RefSeq Acc Id: XM_034935945   ⟹   XP_034791836
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21045,205,454 - 45,219,702 (+)NCBI
NHGRI_mPanPan11245,202,215 - 45,216,463 (+)NCBI
Mhudiblu_PPA_v01239,771,163 - 39,785,411 (+)NCBI
RefSeq Acc Id: XM_034935946   ⟹   XP_034791837
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21045,205,454 - 45,219,702 (+)NCBI
NHGRI_mPanPan11245,202,215 - 45,216,463 (+)NCBI
Mhudiblu_PPA_v01239,771,163 - 39,785,411 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003825867   ⟸   XM_003825819
- UniProtKB: A0A2R9B5H3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034791833   ⟸   XM_034935942
- UniProtKB: A0A2R9B5H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034791834   ⟸   XM_034935943
- UniProtKB: A0A2R9B5H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034791836   ⟸   XM_034935945
- UniProtKB: A0A2R9B5H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034791835   ⟸   XM_034935944
- UniProtKB: A0A2R9B5H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034791837   ⟸   XM_034935946
- UniProtKB: A0A2R9B5H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000024842   ⟸   ENSPPAT00000047668
RefSeq Acc Id: ENSPPAP00000024847   ⟸   ENSPPAT00000047673


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035557 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000047668.1 UniProtKB/TrEMBL
  ENSPPAT00000047673.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt10 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
KEGG Report pps:100995123 UniProtKB/TrEMBL
NCBI Gene WNT10B ENTREZGENE
PANTHER PROTEIN WNT-10B UniProtKB/TrEMBL
  PTHR12027 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNT10PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A2R9B5H3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B5H7_PANPA UniProtKB/TrEMBL