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Gene: SOSTDC1 (sclerostin domain containing 1) Homo sapiens
Symbol: SOSTDC1
Name: sclerostin domain containing 1
Description: Exhibits BMP binding activity and BMP receptor activity. Involved in negative regulation of determination of dorsal identity; negative regulation of myoblast differentiation; and negative regulation of signal transduction. Localizes to the extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDA019; cystine-knot containing secreted protein; DAND7; DKFZp564D206; ectodermal BMP inhibitor; ECTODIN; sclerostin domain-containing protein 1; USAG1; uterine sensitization-associated protein-1; wise
Mus musculus (house mouse) : Sostdc1 (sclerostin domain containing 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sostdc1 (sclerostin domain containing 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sostdc1 (sclerostin domain containing 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SOSTDC1 (sclerostin domain containing 1)
Canis lupus familiaris (dog) : SOSTDC1 (sclerostin domain containing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sostdc1 (sclerostin domain containing 1)
Sus scrofa (pig) : SOSTDC1 (sclerostin domain containing 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl716,461,481 - 16,530,580 (-)Ensembl
GRCh38716,461,481 - 16,465,738 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37716,501,106 - 16,505,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36716,467,631 - 16,471,999 (-)NCBINCBI36hg18NCBI36
Build 34716,274,347 - 16,278,714NCBI
Celera716,480,854 - 16,485,222 (-)NCBI
Cytogenetic Map7p21.2NCBI
HuRef716,387,637 - 16,392,005 (-)NCBIHuRef
CHM1_1716,500,852 - 16,505,220 (-)NCBICHM1_1
CRA_TCAGchr7v2716,554,239 - 16,558,607 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SOSTDC1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1343094
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.