Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1-dichloroethene | decreases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of SOSTDC1 mRNA | CTD | PMID:26682919 | 1,2-dichloroethane | increases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | ethylene dichloride results in increased expression of SOSTDC1 mRNA | CTD | PMID:28960355 | 17alpha-ethynylestradiol | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Ethinyl Estradiol results in decreased expression of SOSTDC1 mRNA | CTD | PMID:17557909 and PMID:29097150 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of SOSTDC1 mRNA | CTD | PMID:26865667 | 17beta-estradiol | affects expression | EXP | | 6480464 | Estradiol affects the expression of SOSTDC1 mRNA | CTD | PMID:14699072 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of SOSTDC1 mRNA | CTD | PMID:30165855 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Sostdc1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Sostdc1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Sostdc1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SOSTDC1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SOSTDC1 mRNA | CTD | PMID:33956508 | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:26705709 | 3,7-dihydropurine-6-thione | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Mercaptopurine results in decreased expression of SOSTDC1 mRNA | CTD | PMID:23358152 | 4,4'-sulfonyldiphenol | increases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | bisphenol S results in increased expression of SOSTDC1 mRNA | CTD | PMID:30951980 | 4-tert-Octylphenol | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | 4-tert-octylphenol results in decreased expression of SOSTDC1 mRNA | CTD | PMID:17011747 | 4-tert-Octylphenol | increases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | 4-tert-octylphenol results in increased expression of SOSTDC1 mRNA | CTD | PMID:17011747 | 6-propyl-2-thiouracil | increases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of SOSTDC1 mRNA | CTD | PMID:24780913 | 6-propyl-2-thiouracil | multiple interactions | ISO | Sostdc1 (Mus musculus) | 6480464 | [Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SOSTDC1 mRNA | CTD | PMID:36706583 | acrylamide | decreases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | Acrylamide results in decreased expression of SOSTDC1 mRNA | CTD | PMID:35032568 | aflatoxin B1 | increases methylation | EXP | | 6480464 | Aflatoxin B1 results in increased methylation of SOSTDC1 gene | CTD | PMID:27153756 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of SOSTDC1 mRNA | CTD | PMID:21934132 | ammonium chloride | affects expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of SOSTDC1 mRNA | CTD | PMID:16483693 | arsenous acid | decreases expression | EXP | | 6480464 | Arsenic Trioxide results in decreased expression of SOSTDC1 mRNA | CTD | PMID:26705709 | benzo[a]pyrene | multiple interactions | ISO | Sostdc1 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of SOSTDC1 mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | increases methylation | EXP | | 6480464 | Benzo(a)pyrene results in increased methylation of SOSTDC1 exon and Benzo(a)pyrene results in increased methylation of SOSTDC1 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of SOSTDC1 mRNA | CTD | PMID:22228805 | Benzo[ghi]perylene | increases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | 1 and 12-benzoperylene results in increased expression of SOSTDC1 mRNA | CTD | PMID:26377693 | bisphenol A | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of SOSTDC1 mRNA | CTD | PMID:25181051 and PMID:29097150 | bisphenol A | decreases methylation | EXP | | 6480464 | bisphenol A results in decreased methylation of SOSTDC1 gene | CTD | PMID:31601247 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of SOSTDC1 gene | CTD | PMID:31601247 | bisphenol A | increases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SOSTDC1 mRNA | CTD | PMID:30951980 | bisphenol F | increases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | bisphenol F results in increased expression of SOSTDC1 mRNA | CTD | PMID:30951980 | bisphenol F | decreases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | bisphenol F results in decreased expression of SOSTDC1 mRNA | CTD | PMID:36706583 | capsaicin | increases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Capsaicin results in increased expression of SOSTDC1 mRNA | CTD | PMID:20349343 | carbon monoxide | multiple interactions | ISO | Sostdc1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of SOSTDC1 mRNA | CTD | PMID:29621558 | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SOSTDC1 gene] | CTD | PMID:28238834 | chloroprene | increases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Chloroprene results in increased expression of SOSTDC1 mRNA | CTD | PMID:23125180 | ciguatoxin CTX1B | affects expression | ISO | Sostdc1 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of SOSTDC1 mRNA | CTD | PMID:18353800 | copper atom | increases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of SOSTDC1 mRNA | CTD | PMID:26033743 | copper(0) | increases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of SOSTDC1 mRNA | CTD | PMID:26033743 | decabromodiphenyl ether | affects expression | EXP | | 6480464 | decabromobiphenyl ether affects the expression of SOSTDC1 mRNA | CTD | PMID:24834073 | diarsenic trioxide | decreases expression | EXP | | 6480464 | Arsenic Trioxide results in decreased expression of SOSTDC1 mRNA | CTD | PMID:26705709 | diazinon | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Diazinon results in decreased expression of SOSTDC1 mRNA | CTD | PMID:29108742 | dibutyl phthalate | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Dibutyl Phthalate results in decreased expression of SOSTDC1 mRNA | CTD | PMID:21266533 | dibutyl phthalate | decreases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of SOSTDC1 mRNA | CTD | PMID:17361019 and PMID:21266533 | diethylstilbestrol | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Diethylstilbestrol results in decreased expression of SOSTDC1 mRNA | CTD | PMID:17011747 | diethylstilbestrol | increases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Diethylstilbestrol results in increased expression of SOSTDC1 mRNA | CTD | PMID:17011747 and PMID:36653537 | diiodine | multiple interactions | ISO | Sostdc1 (Mus musculus) | 6480464 | [Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of SOSTDC1 mRNA | CTD | PMID:36706583 | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | entinostat | decreases expression | EXP | | 6480464 | entinostat results in decreased expression of SOSTDC1 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SOSTDC1 mRNA | CTD | PMID:27188386 | flusilazole | increases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | flusilazole results in increased expression of SOSTDC1 mRNA | CTD | PMID:28263823 | fulvestrant | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of SOSTDC1 gene | CTD | PMID:31601247 | furan | increases methylation | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | furan results in increased methylation of SOSTDC1 gene | CTD | PMID:22079235 | genistein | affects expression | EXP | | 6480464 | Genistein affects the expression of SOSTDC1 mRNA | CTD | PMID:26865667 | genistein | decreases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | Genistein results in decreased expression of SOSTDC1 mRNA | CTD | PMID:32186404 | glycidol | increases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | glycidol results in increased expression of SOSTDC1 mRNA | CTD | PMID:24395379 | glycine betaine | increases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Betaine results in increased expression of SOSTDC1 mRNA | CTD | PMID:26391144 | lead diacetate | decreases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | lead acetate results in decreased expression of SOSTDC1 mRNA | CTD | PMID:22609695 | manganese atom | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Manganese results in decreased expression of SOSTDC1 mRNA | CTD | PMID:26745496 | manganese(0) | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Manganese results in decreased expression of SOSTDC1 mRNA | CTD | PMID:26745496 | manganese(II) chloride | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | manganese chloride results in decreased expression of SOSTDC1 mRNA | CTD | PMID:26745496 | manganese(II) chloride | increases methylation | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | manganese chloride results in increased methylation of SOSTDC1 gene | CTD | PMID:28801915 | mercaptopurine | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Mercaptopurine results in decreased expression of SOSTDC1 mRNA | CTD | PMID:23358152 | N-methyl-4-phenylpyridinium | increases methylation | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased methylation of SOSTDC1 gene | CTD | PMID:28801915 | N-methyl-4-phenylpyridinium | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of SOSTDC1 mRNA | CTD | PMID:28801915 | nickel atom | decreases expression | EXP | | 6480464 | Nickel results in decreased expression of SOSTDC1 mRNA | CTD | PMID:24768652 and PMID:25583101 | nitrofen | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | nitrofen results in decreased expression of SOSTDC1 mRNA | CTD | PMID:33484710 | p-tert-Amylphenol | increases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | 4-tert-octylphenol results in increased expression of SOSTDC1 mRNA | CTD | PMID:17011747 | p-tert-Amylphenol | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | 4-tert-octylphenol results in decreased expression of SOSTDC1 mRNA | CTD | PMID:17011747 | PCB138 | multiple interactions | ISO | Sostdc1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SOSTDC1 mRNA | CTD | PMID:19710929 | pirinixic acid | multiple interactions | ISO | Sostdc1 (Mus musculus) | 6480464 | [pirinixic acid co-treated with PPARA] results in decreased expression of SOSTDC1 mRNA | CTD | PMID:20813756 | pirinixic acid | decreases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of SOSTDC1 mRNA | CTD | PMID:20813756 | purine-6-thiol | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Mercaptopurine results in decreased expression of SOSTDC1 mRNA | CTD | PMID:23358152 | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium arsenate | increases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of SOSTDC1 mRNA | CTD | PMID:21795629 | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of SOSTDC1 mRNA | CTD | PMID:34032870 | sodium chloride | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Sodium Chloride results in decreased expression of SOSTDC1 mRNA | CTD | PMID:37992803 | sodium dichromate | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | sodium bichromate results in decreased expression of SOSTDC1 mRNA | CTD | PMID:22561333 | sodium fluoride | increases expression | ISO | Sostdc1 (Mus musculus) | 6480464 | Sodium Fluoride results in increased expression of SOSTDC1 mRNA | CTD | PMID:27862939 | sulfur dioxide | multiple interactions | ISO | Sostdc1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of SOSTDC1 mRNA | CTD | PMID:29621558 | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of SOSTDC1 mRNA | CTD | PMID:14699072 | titanium dioxide | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | titanium dioxide results in decreased expression of SOSTDC1 mRNA | CTD | PMID:30012374 | toluene | decreases expression | ISO | Sostdc1 (Rattus norvegicus) | 6480464 | Toluene results in decreased expression of SOSTDC1 mRNA | CTD | PMID:22967744 | trichostatin A | increases expression | EXP | | 6480464 | trichostatin A results in increased expression of SOSTDC1 mRNA | CTD | PMID:24935251 | valproic acid | affects expression | ISO | Sostdc1 (Mus musculus) | 6480464 | Valproic Acid affects the expression of SOSTDC1 mRNA | CTD | PMID:17963808 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of SOSTDC1 mRNA | CTD | PMID:25979313 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of SOSTDC1 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOSTDC1 mRNA | CTD | PMID:27188386 | vorinostat | increases expression | EXP | | 6480464 | vorinostat results in increased expression of SOSTDC1 mRNA | CTD | PMID:27188386 | zoledronic acid | increases expression | EXP | | 6480464 | zoledronic acid results in increased expression of SOSTDC1 mRNA | CTD | PMID:24714768 | |