MIR144 (microRNA 144) - Rat Genome Database

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Gene: MIR144 (microRNA 144) Homo sapiens
Analyze
Symbol: MIR144
Name: microRNA 144
RGD ID: 1350288
HGNC Page HGNC:31531
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing post-transcriptional repressor activity. Involved in several processes, including negative regulation of cellular macromolecule biosynthetic process; negative regulation of cholesterol transport; and positive regulation of cytokine production. Acts upstream of or within negative regulation of gene expression; positive regulation of cell adhesion molecule production; and positive regulation of gene expression. Located in extracellular space.
Type: ncrna
RefSeq Status: PROVISIONAL
Previously known as: mir-144; MIRN144
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,861,533 - 28,861,618 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1728,861,533 - 28,861,618 (-)EnsemblGRCh38hg38GRCh38
GRCh371727,188,551 - 27,188,636 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361724,212,676 - 24,212,761 (-)NCBINCBI36Build 36hg18NCBI36
Celera1724,047,975 - 24,048,060 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1723,396,841 - 23,396,926 (-)NCBIHuRef
CHM1_11727,251,065 - 27,251,150 (-)NCBICHM1_1
T2T-CHM13v2.01729,804,306 - 29,804,391 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Traumatic brain injury dysregulates microRNAs to modulate cell signaling in rat hippocampus. Liu L, etal., PLoS One. 2014 Aug 4;9(8):e103948. doi: 10.1371/journal.pone.0103948. eCollection 2014.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12007417   PMID:16381832   PMID:17604727   PMID:18303114   PMID:18766170   PMID:18941117   PMID:20451302   PMID:20709907   PMID:21037258   PMID:21367459   PMID:21829658   PMID:21863218  
PMID:22955854   PMID:22983984   PMID:23125220   PMID:23226399   PMID:23519695   PMID:23519696   PMID:23546882   PMID:23815091   PMID:24195082   PMID:24453045   PMID:24497980   PMID:24733347  
PMID:24968735   PMID:25060662   PMID:25064468   PMID:25073510   PMID:25151965   PMID:25312678   PMID:25318625   PMID:25370363   PMID:25479763   PMID:25660220   PMID:25854173   PMID:25907866  
PMID:25912304   PMID:25927670   PMID:25961751   PMID:26057453   PMID:26078353   PMID:26097586   PMID:26191328   PMID:26252024   PMID:26349975   PMID:26458302   PMID:26646931   PMID:26687302  
PMID:26826553   PMID:26945479   PMID:26959737   PMID:26990493   PMID:27036026   PMID:27072960   PMID:27297132   PMID:27329039   PMID:27364533   PMID:27556228   PMID:27572636   PMID:27633984  
PMID:27717821   PMID:27748283   PMID:27764573   PMID:27785072   PMID:28111340   PMID:28229969   PMID:28270228   PMID:28574724   PMID:28653602   PMID:28663050   PMID:28742204   PMID:28762326  
PMID:28772212   PMID:28800316   PMID:28849156   PMID:28885863   PMID:28902349   PMID:29028093   PMID:29073615   PMID:29284789   PMID:29334613   PMID:29441994   PMID:29561704   PMID:29684757  
PMID:29791864   PMID:29885402   PMID:29940778   PMID:29955039   PMID:29968393   PMID:30024602   PMID:30132256   PMID:30143484   PMID:30280514   PMID:30312706   PMID:30375717   PMID:30412705  
PMID:30450635   PMID:30499593   PMID:30511586   PMID:30536308   PMID:30536309   PMID:30542710   PMID:30544723   PMID:30551440   PMID:30674565   PMID:30709904   PMID:30714135   PMID:30720179  
PMID:30745456   PMID:30811958   PMID:30816505   PMID:30832674   PMID:30834525   PMID:30949910   PMID:30975221   PMID:31016619   PMID:31017260   PMID:31017720   PMID:31115543   PMID:31138258  
PMID:31216561   PMID:31217548   PMID:31227612   PMID:31243572   PMID:31292167   PMID:31297834   PMID:31357838   PMID:31381886   PMID:31539115   PMID:31566128   PMID:31609763   PMID:31659146  
PMID:31747378   PMID:31809872   PMID:31841443   PMID:31853766   PMID:31907983   PMID:31918742   PMID:31973536   PMID:31973741   PMID:32076107   PMID:32102682   PMID:32206063   PMID:32276343  
PMID:32538067   PMID:32550890   PMID:32557658   PMID:32613412   PMID:32669469   PMID:32705159   PMID:32798408   PMID:32844953   PMID:32917949   PMID:32951513   PMID:32999164   PMID:33015777  
PMID:33155199   PMID:33215418   PMID:33256799   PMID:33403569   PMID:33417281   PMID:33452670   PMID:33459113   PMID:33464142   PMID:33465419   PMID:33473145   PMID:33496921   PMID:33526055  
PMID:33550923   PMID:33591945   PMID:33772768   PMID:33847879   PMID:34034455   PMID:34226299   PMID:34240392   PMID:34325120   PMID:34326893   PMID:34340698   PMID:34364983   PMID:34425095  
PMID:34435195   PMID:34634995   PMID:34657624   PMID:34699621   PMID:34895046   PMID:34910830   PMID:34938358   PMID:35126910   PMID:35204817   PMID:35332577   PMID:35378445   PMID:35459267  
PMID:35568918   PMID:35616822   PMID:35692876   PMID:35801921   PMID:35818213   PMID:35967345  


Genomics

Comparative Map Data
MIR144
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,861,533 - 28,861,618 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1728,861,533 - 28,861,618 (-)EnsemblGRCh38hg38GRCh38
GRCh371727,188,551 - 27,188,636 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361724,212,676 - 24,212,761 (-)NCBINCBI36Build 36hg18NCBI36
Celera1724,047,975 - 24,048,060 (-)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1723,396,841 - 23,396,926 (-)NCBIHuRef
CHM1_11727,251,065 - 27,251,150 (-)NCBICHM1_1
T2T-CHM13v2.01729,804,306 - 29,804,391 (-)NCBIT2T-CHM13v2.0
Mir144
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391177,963,831 - 77,963,896 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1177,963,831 - 77,963,896 (+)EnsemblGRCm39 Ensembl
GRCm381178,073,005 - 78,073,070 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,073,005 - 78,073,070 (+)EnsemblGRCm38mm10GRCm38
MGSCv371177,886,507 - 77,886,572 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1185,572,607 - 85,572,672 (+)NCBICelera
Cytogenetic Map11B5NCBI
Mir144
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21062,961,348 - 62,961,430 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1062,961,348 - 62,961,430 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1067,592,522 - 67,592,604 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01067,097,886 - 67,097,968 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01062,569,460 - 62,569,542 (+)NCBIRnor_WKY
Rnor_6.01065,291,365 - 65,291,447 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,291,365 - 65,291,447 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01066,340,681 - 66,340,763 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1061,939,438 - 61,939,520 (+)NCBICelera
Cytogenetic Map10q25NCBI
MIR144
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1943,031,035 - 43,031,094 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl943,031,035 - 43,031,094 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha942,186,177 - 42,186,236 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,848,755 - 43,848,814 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,848,755 - 43,848,814 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,632,295 - 42,632,354 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,924,318 - 42,924,377 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0943,002,958 - 43,003,017 (-)NCBIUU_Cfam_GSD_1.0
MIR144
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1245,088,959 - 45,089,035 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11245,088,958 - 45,089,033 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21247,176,953 - 47,177,028 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
PLAG1hsa-miR-144-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19347935
FGGhsa-miR-144-3pMirtarbaseexternal_infoELISA//Flow//Luciferase reporter assayFunctional MTI20570858
FGAhsa-miR-144-3pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI20570858
NOTCH1hsa-miR-144-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21285251
MTORhsa-miR-144-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22983984
PTENhsa-miR-144-3pMirtarbaseexternal_infoImmunoprecipitaion//Luciferase reporter assay//qRTFunctional MTI23125220
NFE2L2hsa-miR-144-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23236440
PTENhsa-miR-144-3pOncomiRDBexternal_infoNANA23125220
MTORhsa-miR-144-3pOncomiRDBexternal_infoNANA22983984
ZFXhsa-miR-144-3pOncomiRDBexternal_infoNANA22955854

Predicted Targets
Summary Value
Count of predictions:22650
Count of gene targets:8196
Count of transcripts:16060
Interacting mature miRNAs:hsa-miR-144-3p, hsa-miR-144-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384886
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,861,533 - 28,861,618 (-)Ensembl
RefSeq Acc Id: NR_029685
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381728,861,533 - 28,861,618 (-)NCBI
GRCh371727,188,551 - 27,188,636 (-)RGD
Celera1724,047,975 - 24,048,060 (-)RGD
HuRef1723,396,841 - 23,396,926 (-)ENTREZGENE
CHM1_11727,251,065 - 27,251,150 (-)NCBI
T2T-CHM13v2.01729,804,306 - 29,804,391 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_005702.2(ERAL1):c.490-1G>A single nucleotide variant Malignant melanoma [RCV000063172] Chr17:28857938 [GRCh38]
Chr17:27184956 [GRCh37]
Chr17:24209082 [NCBI36]
Chr17:17q11.2
not provided
GRCh38/hg38 17q11.2(chr17:28283125-28904397)x3 copy number gain See cases [RCV000136494] Chr17:28283125..28904397 [GRCh38]
Chr17:26610151..27231415 [GRCh37]
Chr17:23634278..24255541 [NCBI36]
Chr17:17q11.2
benign
GRCh38/hg38 17q11.2(chr17:28757283-29216419)x3 copy number gain See cases [RCV000142450] Chr17:28757283..29216419 [GRCh38]
Chr17:27084301..27543437 [GRCh37]
Chr17:24108428..24567563 [NCBI36]
Chr17:17q11.2
uncertain significance
GRCh37/hg19 17q11.1-11.2(chr17:25403446-31685464)x3 copy number gain not provided [RCV000762776] Chr17:25403446..31685464 [GRCh37]
Chr17:17q11.1-11.2
likely pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q11.1-11.2(chr17:25248166-30645676)x1 copy number loss Mitogen-activated protein kinase kinase inhibitor response [RCV000626439] Chr17:25248166..30645676 [GRCh37]
Chr17:17q11.1-11.2
drug response
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p11.2-q11.2(chr17:21279289-27474974)x2 copy number gain not provided [RCV000739439] Chr17:21279289..27474974 [GRCh37]
Chr17:17p11.2-q11.2
likely pathogenic
GRCh37/hg19 17p11.2-q21.2(chr17:21690653-38772647)x3 copy number gain not provided [RCV000846852] Chr17:21690653..38772647 [GRCh37]
Chr17:17p11.2-q21.2
pathogenic
GRCh37/hg19 17q11.1-11.2(chr17:25274363-28450707)x3 copy number gain not provided [RCV001006886] Chr17:25274363..28450707 [GRCh37]
Chr17:17q11.1-11.2
pathogenic
GRCh37/hg19 17p11.2-q11.2(chr17:21690653-28281232) copy number gain not specified [RCV002052591] Chr17:21690653..28281232 [GRCh37]
Chr17:17p11.2-q11.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31531 AgrOrtholog
COSMIC MIR144 COSMIC
Ensembl Genes ENSG00000283819 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384886 ENTREZGENE
GTEx ENSG00000283819 GTEx
HGNC ID HGNC:31531 ENTREZGENE
Human Proteome Map MIR144 Human Proteome Map
miRBase MI0000460 ENTREZGENE
NCBI Gene 406936 ENTREZGENE
OMIM 612070 OMIM
PharmGKB PA164722493 PharmGKB
RNAcentral URS00002E92A8 RNACentral
  URS000037C5A8 RNACentral
  URS000075BB92 RNACentral