OGN (osteoglycin) - Rat Genome Database

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Gene: OGN (osteoglycin) Homo sapiens
Analyze
Symbol: OGN
Name: osteoglycin
RGD ID: 1317793
HGNC Page HGNC:8126
Description: Predicted to enable growth factor activity. Predicted to be an extracellular matrix structural constituent conferring compression resistance. Predicted to be involved in articular cartilage development; bone development; and negative regulation of smooth muscle cell proliferation. Located in endoplasmic reticulum.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: corneal keratan sulfate proteoglycan; DKFZp586P2421; mimecan; mimecan proteoglycan; OG; OIF; osteoglycin (osteoinductive factor, mimecan); osteoinductive factor; SLRR3A
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38992,383,268 - 92,404,699 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl992,383,268 - 92,404,696 (-)EnsemblGRCh38hg38GRCh38
GRCh37995,145,550 - 95,166,981 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36994,186,070 - 94,206,758 (-)NCBINCBI36Build 36hg18NCBI36
Celera965,588,282 - 65,608,970 (-)NCBICelera
Cytogenetic Map9q22.31NCBI
HuRef964,823,710 - 64,844,399 (-)NCBIHuRef
CHM1_1995,292,689 - 95,313,376 (-)NCBICHM1_1
T2T-CHM13v2.09104,549,769 - 104,571,196 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-tribromophenol  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acrylamide  (ISO)
aldrin  (ISO)
antirheumatic drug  (EXP)
arsenous acid  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (EXP)
cisplatin  (EXP)
cobalt atom  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
epoxiconazole  (ISO)
furan  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
glyphosate  (ISO)
graphene oxide  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP)
lipopolysaccharide  (EXP)
mercaptopurine  (ISO)
methotrexate  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
phenylephrine  (ISO)
potassium dichromate  (ISO)
purine-6-thiol  (ISO)
rac-lactic acid  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
serpentine asbestos  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
tacrolimus hydrate  (ISO)
tadalafil  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
triclosan  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2326263   PMID:2372374   PMID:8889548   PMID:9346963   PMID:10656267   PMID:10802664   PMID:10828622   PMID:10931946   PMID:11076863   PMID:11230166   PMID:11256614   PMID:12477932  
PMID:12533723   PMID:13679028   PMID:15164053   PMID:15340161   PMID:15489334   PMID:15489336   PMID:16189248   PMID:16303743   PMID:16381901   PMID:17474147   PMID:17895523   PMID:18243607  
PMID:19453261   PMID:19913121   PMID:20360993   PMID:20379614   PMID:20551380   PMID:20628086   PMID:21873635   PMID:23533145   PMID:23714241   PMID:24651681   PMID:24769233   PMID:25037231  
PMID:25371314   PMID:25463067   PMID:25953442   PMID:26045825   PMID:26170933   PMID:26186194   PMID:26206738   PMID:26870797   PMID:27068509   PMID:27508318   PMID:27559042   PMID:27836731  
PMID:27878326   PMID:28069703   PMID:28514442   PMID:28675934   PMID:28824047   PMID:28931407   PMID:28958774   PMID:29262349   PMID:29499765   PMID:29503411   PMID:29867136   PMID:29987050  
PMID:30037719   PMID:30561431   PMID:30862715   PMID:32087327   PMID:32755451   PMID:32964764   PMID:33032238   PMID:33215216   PMID:33622177   PMID:33961781   PMID:35850021   PMID:35908351  


Genomics

Comparative Map Data
OGN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38992,383,268 - 92,404,699 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl992,383,268 - 92,404,696 (-)EnsemblGRCh38hg38GRCh38
GRCh37995,145,550 - 95,166,981 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36994,186,070 - 94,206,758 (-)NCBINCBI36Build 36hg18NCBI36
Celera965,588,282 - 65,608,970 (-)NCBICelera
Cytogenetic Map9q22.31NCBI
HuRef964,823,710 - 64,844,399 (-)NCBIHuRef
CHM1_1995,292,689 - 95,313,376 (-)NCBICHM1_1
T2T-CHM13v2.09104,549,769 - 104,571,196 (-)NCBIT2T-CHM13v2.0
Ogn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391349,761,491 - 49,777,977 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1349,761,522 - 49,777,977 (+)EnsemblGRCm39 Ensembl
GRCm381349,608,015 - 49,624,501 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1349,608,046 - 49,624,501 (+)EnsemblGRCm38mm10GRCm38
MGSCv371349,703,440 - 49,719,869 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361349,620,008 - 49,636,437 (+)NCBIMGSCv36mm8
Celera1350,698,836 - 50,715,265 (+)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1325.34NCBI
Ogn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81715,238,500 - 15,259,167 (-)NCBIGRCr8
mRatBN7.21715,032,069 - 15,052,626 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1715,032,069 - 15,052,739 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1714,919,266 - 14,939,703 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01716,524,322 - 16,544,765 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01714,846,060 - 14,866,498 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01714,607,442 - 14,628,274 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1715,447,716 - 15,467,359 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1714,607,442 - 14,627,937 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01717,506,166 - 17,527,131 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41720,987,029 - 21,007,525 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11720,987,030 - 21,007,504 (-)NCBI
Celera1714,763,600 - 14,783,780 (-)NCBICelera
Cytogenetic Map17p14NCBI
Ogn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555155,372,034 - 5,389,954 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555155,372,225 - 5,389,954 (+)NCBIChiLan1.0ChiLan1.0
OGN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21147,023,831 - 47,045,720 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1947,026,287 - 47,048,803 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0963,505,165 - 63,527,761 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1991,578,833 - 91,600,741 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl991,578,833 - 91,600,738 (-)Ensemblpanpan1.1panPan2
OGN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1198,939,374 - 98,959,173 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl198,939,429 - 98,957,543 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha199,333,213 - 99,353,015 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0199,556,194 - 99,575,993 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl199,555,768 - 99,627,336 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1199,169,271 - 99,189,070 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0198,904,553 - 98,924,354 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0199,661,321 - 99,681,130 (+)NCBIUU_Cfam_GSD_1.0
Ogn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049447,813,284 - 7,827,902 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364872,028,948 - 2,044,387 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364872,029,755 - 2,043,242 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OGN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl342,116,526 - 42,135,939 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1342,116,521 - 42,135,940 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2343,250,528 - 43,259,180 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OGN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112102,908,482 - 102,928,956 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12102,908,479 - 102,928,827 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603891,180,673 - 91,201,156 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ogn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248683,950,154 - 3,971,674 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248683,950,145 - 3,974,359 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in OGN
5 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q22.31-22.33(chr9:91596533-97018746)x1 copy number loss See cases [RCV000052916] Chr9:91596533..97018746 [GRCh38]
Chr9:94358815..99781028 [GRCh37]
Chr9:93398636..98820849 [NCBI36]
Chr9:9q22.31-22.33		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q22.1-32(chr9:88522292-113687796)x3 copy number gain See cases [RCV000053752] Chr9:88522292..113687796 [GRCh38]
Chr9:91137207..116450076 [GRCh37]
Chr9:90327027..115489897 [NCBI36]
Chr9:9q22.1-32		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q21.11-31.2(chr9:68420430-106579493)x3 copy number gain See cases [RCV000136788] Chr9:68420430..106579493 [GRCh38]
Chr9:71130848..109341774 [GRCh37]
Chr9:70225166..108381595 [NCBI36]
Chr9:9q21.11-31.2		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic|conflicting data from submitters
GRCh38/hg38 9q21.12-31.3(chr9:69627642-111454304)x3 copy number gain See cases [RCV000139789] Chr9:69627642..111454304 [GRCh38]
Chr9:72242558..114216584 [GRCh37]
Chr9:71432378..113256405 [NCBI36]
Chr9:9q21.12-31.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q22.31(chr9:95051642-95264865)x3 copy number gain Breast ductal adenocarcinoma [RCV000207122] Chr9:95051642..95264865 [GRCh37]
Chr9:9q22.31		 uncertain significance
GRCh38/hg38 9q22.31(chr9:92301666-92417555)x1 copy number loss Premature ovarian failure [RCV000225325] Chr9:92301666..92417555 [GRCh38]
Chr9:95063947..95179836 [GRCh37]
Chr9:9q22.31		 likely pathogenic|uncertain significance
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain not specified [RCV003986800] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q22.31(chr9:95130400-95454546)x1 copy number loss See cases [RCV000448721] Chr9:95130400..95454546 [GRCh37]
Chr9:9q22.31		 uncertain significance
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71069743-140999928) copy number gain Global developmental delay [RCV000626548] Chr9:71069743..140999928 [GRCh37]
Chr9:9q21.11-34.3		 likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q22.31(chr9:94907633-96493970)x1 copy number loss not provided [RCV000683156] Chr9:94907633..96493970 [GRCh37]
Chr9:9q22.31		 uncertain significance
GRCh37/hg19 9q22.31(chr9:94974188-95228663)x3 copy number gain not provided [RCV000748524] Chr9:94974188..95228663 [GRCh37]
Chr9:9q22.31		 benign
GRCh37/hg19 9q22.31(chr9:95044229-95360764)x3 copy number gain not provided [RCV000748525] Chr9:95044229..95360764 [GRCh37]
Chr9:9q22.31		 benign
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q21.2-22.32(chr9:79520825-97201274) copy number gain not provided [RCV000767645] Chr9:79520825..97201274 [GRCh37]
Chr9:9q21.2-22.32		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q22.31(chr9:94667669-95345847)x3 copy number gain not provided [RCV000847811] Chr9:94667669..95345847 [GRCh37]
Chr9:9q22.31		 uncertain significance
GRCh37/hg19 9q22.31(chr9:95123353-95453320)x1 copy number loss not provided [RCV000849491] Chr9:95123353..95453320 [GRCh37]
Chr9:9q22.31		 uncertain significance
GRCh37/hg19 9q22.31(chr9:95058076-95292831)x1 copy number loss not provided [RCV000847503] Chr9:95058076..95292831 [GRCh37]
Chr9:9q22.31		 uncertain significance
GRCh37/hg19 9q21.11-34.3(chr9:71416475-141020389)x3 copy number gain not provided [RCV000847808] Chr9:71416475..141020389 [GRCh37]
Chr9:9q21.11-34.3		 pathogenic
GRCh37/hg19 9q22.31(chr9:95076710-95263214)x1 copy number loss not provided [RCV002472702] Chr9:95076710..95263214 [GRCh37]
Chr9:9q22.31		 uncertain significance
GRCh37/hg19 9q22.31(chr9:95079793-95503060)x1 copy number loss not provided [RCV001006246] Chr9:95079793..95503060 [GRCh37]
Chr9:9q22.31		 uncertain significance
GRCh37/hg19 9q22.31(chr9:94671200-95325631)x3 copy number gain See cases [RCV001007416] Chr9:94671200..95325631 [GRCh37]
Chr9:9q22.31		 uncertain significance
GRCh37/hg19 9q22.31(chr9:95146115-95280874)x1 copy number loss not provided [RCV001006247] Chr9:95146115..95280874 [GRCh37]
Chr9:9q22.31		 uncertain significance
NC_000009.11:g.(?_95007241)_(95237179_?)del deletion not provided [RCV001387104] Chr9:95007241..95237179 [GRCh37]
Chr9:9q22.31		 pathogenic
NC_000009.11:g.12246100_101559378inv inversion Recurrent spontaneous abortion [RCV000999471] Chr9:12246100..101559378 [GRCh37]
Chr9:9p23-q22.33		 likely pathogenic
GRCh37/hg19 9q22.31(chr9:95052447-95382122)x3 copy number gain not provided [RCV001827977] Chr9:95052447..95382122 [GRCh37]
Chr9:9q22.31		 uncertain significance
GRCh37/hg19 9p24.3-q34.3(chr9:353349-141020389) copy number gain not specified [RCV002053823] Chr9:353349..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q21.11-33.2(chr9:71349994-122603410) copy number gain not specified [RCV002053853] Chr9:71349994..122603410 [GRCh37]
Chr9:9q21.11-33.2		 likely pathogenic
NC_000009.11:g.(?_94794747)_(95527026_?)del deletion Autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures [RCV001900344]|Hereditary sensory and autonomic neuropathy type 1 [RCV001875146] Chr9:94794747..95527026 [GRCh37]
Chr9:9q22.31		 uncertain significance
GRCh37/hg19 9q22.2-31.1(chr9:93864974-106661581)x1 copy number loss Gorlin syndrome [RCV002279743] Chr9:93864974..106661581 [GRCh37]
Chr9:9q22.2-31.1		 pathogenic
GRCh37/hg19 9p24.3-q34.11(chr9:203861-131603223)x3 copy number gain See cases [RCV002292402] Chr9:203861..131603223 [GRCh37]
Chr9:9p24.3-q34.11		 pathogenic
GRCh37/hg19 9p22.1-q33.1(chr9:19356861-119513311) copy number loss Distal tetrasomy 15q [RCV002280776] Chr9:19356861..119513311 [GRCh37]
Chr9:9p22.1-q33.1		 uncertain significance
GRCh37/hg19 9q22.31(chr9:95079794-95503060)x1 copy number loss not provided [RCV002475609] Chr9:95079794..95503060 [GRCh37]
Chr9:9q22.31		 uncertain significance
GRCh37/hg19 9q22.31(chr9:94666958-95339157)x3 copy number gain not provided [RCV002475857] Chr9:94666958..95339157 [GRCh37]
Chr9:9q22.31		 uncertain significance
NM_014057.5(OGN):c.242C>T (p.Pro81Leu) single nucleotide variant Inborn genetic diseases [RCV002883631] Chr9:92401118 [GRCh38]
Chr9:95163400 [GRCh37]
Chr9:9q22.31		 uncertain significance
NM_014057.5(OGN):c.83G>A (p.Arg28His) single nucleotide variant Inborn genetic diseases [RCV002823201] Chr9:92403325 [GRCh38]
Chr9:95165607 [GRCh37]
Chr9:9q22.31		 uncertain significance
NM_014057.5(OGN):c.79T>A (p.Ser27Thr) single nucleotide variant Inborn genetic diseases [RCV002984810] Chr9:92403329 [GRCh38]
Chr9:95165611 [GRCh37]
Chr9:9q22.31		 uncertain significance
NM_014057.5(OGN):c.364G>A (p.Ala122Thr) single nucleotide variant Inborn genetic diseases [RCV002827449] Chr9:92393149 [GRCh38]
Chr9:95155431 [GRCh37]
Chr9:9q22.31		 uncertain significance
NM_014057.5(OGN):c.665A>G (p.His222Arg) single nucleotide variant Inborn genetic diseases [RCV003385499] Chr9:92386262 [GRCh38]
Chr9:95148544 [GRCh37]
Chr9:9q22.31		 uncertain significance
Single allele deletion not provided [RCV003448676] Chr9:92679543..109378847 [GRCh37]
Chr9:9q22.2-31.2		 pathogenic
GRCh37/hg19 9q22.31(chr9:94666957-95345707)x3 copy number gain not specified [RCV003986810] Chr9:94666957..95345707 [GRCh37]
Chr9:9q22.31		 uncertain significance
NC_000009.11:g.(?_94485944)_(95527026_?)del deletion not provided [RCV003113522] Chr9:94485944..95527026 [GRCh37]
Chr9:9q22.31		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1024
Count of miRNA genes:431
Interacting mature miRNAs:451
Transcripts:ENST00000262551, ENST00000375561, ENST00000447356, ENST00000468743
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH36468  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37995,147,389 - 95,147,525UniSTSGRCh37
Build 36994,187,210 - 94,187,346RGDNCBI36
Celera965,589,422 - 65,589,558RGD
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map9q22UniSTS
HuRef964,824,850 - 64,824,986UniSTS
GeneMap99-GB4 RH Map9304.09UniSTS
RH80964  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37995,147,320 - 95,147,553UniSTSGRCh37
Build 36994,187,141 - 94,187,374RGDNCBI36
Celera965,589,353 - 65,589,586RGD
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map9q22UniSTS
HuRef964,824,781 - 64,825,014UniSTS
GeneMap99-GB4 RH Map9305.29UniSTS
OGN_8519  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37995,146,781 - 95,147,612UniSTSGRCh37
Build 36994,186,602 - 94,187,433RGDNCBI36
Celera965,588,814 - 65,589,645RGD
HuRef964,824,242 - 64,825,073UniSTS
RH16376  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37995,146,388 - 95,146,551UniSTSGRCh37
Build 36994,186,209 - 94,186,372RGDNCBI36
Celera965,588,421 - 65,588,584RGD
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map9q22UniSTS
HuRef964,823,849 - 64,824,012UniSTS
GeneMap99-GB4 RH Map9304.09UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 131 2 3 2
Medium 1756 1734 729 22 121 21 1733 998 824 50 880 891 4 1 852 1287 2
Low 525 432 726 314 411 205 1932 812 2037 182 411 453 110 350 1101 2 1
Below cutoff 67 644 213 251 1202 198 585 360 819 97 66 116 58 2 398 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_014057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_024416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF086912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF088023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF100758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF112465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF173383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF202167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH008814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI424992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL110267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL133114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL137848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX616337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC095443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG772245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM679549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX646984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB268982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR533516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000262551   ⟹   ENSP00000262551
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl992,383,967 - 92,404,559 (-)Ensembl
RefSeq Acc Id: ENST00000375561   ⟹   ENSP00000364711
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl992,383,268 - 92,404,578 (-)Ensembl
RefSeq Acc Id: ENST00000447356   ⟹   ENSP00000396709
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl992,389,854 - 92,404,696 (-)Ensembl
RefSeq Acc Id: ENST00000468743
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl992,389,641 - 92,393,152 (-)Ensembl
RefSeq Acc Id: NM_014057   ⟹   NP_054776
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38992,383,268 - 92,404,578 (-)NCBI
GRCh37995,146,249 - 95,166,976 (-)NCBI
Build 36994,186,070 - 94,206,758 (-)NCBI Archive
HuRef964,823,710 - 64,844,399 (-)ENTREZGENE
CHM1_1995,291,993 - 95,313,420 (-)NCBI
T2T-CHM13v2.09104,549,769 - 104,571,075 (-)NCBI
Sequence:
RefSeq Acc Id: NM_024416   ⟹   NP_077727
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38992,383,271 - 92,404,699 (-)NCBI
Build 36994,186,070 - 94,206,758 (-)NCBI Archive
CHM1_1995,291,993 - 95,313,420 (-)NCBI
T2T-CHM13v2.09104,549,772 - 104,571,196 (-)NCBI
Sequence:
RefSeq Acc Id: NM_033014   ⟹   NP_148935
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38992,383,268 - 92,404,578 (-)NCBI
GRCh37995,146,249 - 95,166,976 (-)NCBI
Build 36994,186,070 - 94,206,758 (-)NCBI Archive
HuRef964,823,710 - 64,844,399 (-)ENTREZGENE
CHM1_1995,291,993 - 95,313,420 (-)NCBI
T2T-CHM13v2.09104,549,769 - 104,571,075 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_054776   ⟸   NM_014057
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9UF90 (UniProtKB/Swiss-Prot),   Q6FIB0 (UniProtKB/Swiss-Prot),   Q9UNK5 (UniProtKB/Swiss-Prot),   P20774 (UniProtKB/Swiss-Prot),   A8K0R3 (UniProtKB/TrEMBL),   Q7Z532 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_148935   ⟸   NM_033014
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9UF90 (UniProtKB/Swiss-Prot),   Q6FIB0 (UniProtKB/Swiss-Prot),   Q9UNK5 (UniProtKB/Swiss-Prot),   P20774 (UniProtKB/Swiss-Prot),   A8K0R3 (UniProtKB/TrEMBL),   Q7Z532 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_077727   ⟸   NM_024416
- Peptide Label: isoform 1
- UniProtKB: B4DI63 (UniProtKB/TrEMBL),   Q7Z532 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000364711   ⟸   ENST00000375561
RefSeq Acc Id: ENSP00000396709   ⟸   ENST00000447356
RefSeq Acc Id: ENSP00000262551   ⟸   ENST00000262551

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20774-F1-model_v2 AlphaFold P20774 1-298 view protein structure

Promoters
RGD ID:7215471
Promoter ID:EPDNEW_H13482
Type:initiation region
Name:OGN_2
Description:osteoglycin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13483  EPDNEW_H13484  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38992,403,490 - 92,403,550EPDNEW
RGD ID:7215473
Promoter ID:EPDNEW_H13483
Type:initiation region
Name:OGN_1
Description:osteoglycin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13482  EPDNEW_H13484  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38992,404,578 - 92,404,638EPDNEW
RGD ID:7215475
Promoter ID:EPDNEW_H13484
Type:multiple initiation site
Name:OGN_3
Description:osteoglycin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13482  EPDNEW_H13483  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38992,406,734 - 92,406,794EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8126 AgrOrtholog
COSMIC OGN COSMIC
Ensembl Genes ENSG00000106809 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000291350 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000262551 ENTREZGENE
  ENST00000262551.8 UniProtKB/Swiss-Prot
  ENST00000375561 ENTREZGENE
  ENST00000375561.10 UniProtKB/Swiss-Prot
  ENST00000447356.1 UniProtKB/TrEMBL
  ENST00000707237.1 UniProtKB/Swiss-Prot
  ENST00000707238.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000106809 GTEx
  ENSG00000291350 GTEx
HGNC ID HGNC:8126 ENTREZGENE
Human Proteome Map OGN Human Proteome Map
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mimecan/Epiphycan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4969 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 4969 ENTREZGENE
OMIM 602383 OMIM
PANTHER PTHR46269 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46269:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA31913 PharmGKB
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K0R3 ENTREZGENE, UniProtKB/TrEMBL
  B4DI63 ENTREZGENE, UniProtKB/TrEMBL
  MIME_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q5TBF5_HUMAN UniProtKB/TrEMBL
  Q6FIB0 ENTREZGENE
  Q7Z532 ENTREZGENE, UniProtKB/TrEMBL
  Q9UF90 ENTREZGENE
  Q9UNK5 ENTREZGENE
UniProt Secondary Q6FIB0 UniProtKB/Swiss-Prot
  Q9UF90 UniProtKB/Swiss-Prot
  Q9UNK5 UniProtKB/Swiss-Prot