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Gene: CLIC2 (chloride intracellular channel 2) Homo sapiens
Symbol: CLIC2
Name: chloride intracellular channel 2
Description: Exhibits glutathione peroxidase activity. Involved in negative regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of binding activity; and regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Localizes to the cytoplasm. Implicated in X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: chloride intracellular channel protein 2; CLCNL2; CLIC2b; MRXS32; XAP121
Rattus norvegicus (Norway rat) : Clic2 (chloride intracellular channel 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clic2 (chloride intracellular channel 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CLIC2 (chloride intracellular channel 2)
Canis lupus familiaris (dog) : CLIC2 (chloride intracellular channel 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clic2 (chloride intracellular channel 2)
Sus scrofa (pig) : CLIC2 (chloride intracellular channel 2)
Chlorocebus sabaeus (African green monkey) : CLIC2 (chloride intracellular channel 2)
Heterocephalus glaber (naked mole-rat) : Clic2 (chloride intracellular channel 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX155,276,211 - 155,334,657 (-)Ensembl
GRCh38X155,276,211 - 155,334,614 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X154,505,500 - 154,563,997 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X154,158,694 - 154,217,180 (-)NCBINCBI36hg18NCBI36
Build 34X154,070,159 - 154,127,661NCBI
CeleraX154,664,011 - 154,722,432 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX143,049,088 - 143,107,752 (-)NCBIHuRef
CHM1_1X154,416,158 - 154,475,626 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CLIC2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315278
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.