HTRA3 (HtrA serine peptidase 3) - Rat Genome Database

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Gene: HTRA3 (HtrA serine peptidase 3) Homo sapiens
Analyze
Symbol: HTRA3
Name: HtrA serine peptidase 3
RGD ID: 1354015
HGNC Page HGNC:30406
Description: Enables endopeptidase activity; identical protein binding activity; and serine-type peptidase activity. Involved in proteolysis. Predicted to be located in extracellular region.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: high-temperature requirement factor A3; pregnancy-related serine protease; probable serine protease HTRA3; Prsp; serine protease HTRA3; Tasp
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3848,269,754 - 8,307,098 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl48,269,754 - 8,307,098 (+)EnsemblGRCh38hg38GRCh38
GRCh3748,271,481 - 8,308,825 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3648,322,392 - 8,359,734 (+)NCBINCBI36Build 36hg18NCBI36
Build 3448,389,562 - 8,426,901NCBI
Celera48,163,395 - 8,202,090 (+)NCBICelera
Cytogenetic Map4p16.1NCBI
HuRef48,191,265 - 8,229,449 (+)NCBIHuRef
CHM1_148,269,374 - 8,307,228 (+)NCBICHM1_1
T2T-CHM13v2.048,248,531 - 8,287,062 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HTRA3HumanMycoplasma pneumoniae pneumonia severityHEP 32716376 RGD 

1 to 20 of 103 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HTRA3Human(1->4)-beta-D-glucan multiple interactionsISOHtra3 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of HTRA3 mRNACTDPMID:36331819
HTRA3Human1,2-dimethylhydrazine decreases expressionISOHtra3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of HTRA3 mRNACTDPMID:22206623
HTRA3Human17alpha-ethynylestradiol multiple interactionsISOHtra3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HTRA3 mRNACTDPMID:17942748
HTRA3Human17beta-estradiol multiple interactionsEXP 6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of HTRA3 mRNACTDPMID:30165855
HTRA3Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOHtra3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HTRA3 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HTRA3 promoter]CTDPMID:17942748 and PMID:19654925
HTRA3Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISOHtra3 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin affects the expression of HTRA3 mRNACTDPMID:34747641
HTRA3Human2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of HTRA3 mRNACTDPMID:21998131
HTRA3Human2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOHtra3 (Mus musculus)64804642 more ...CTDPMID:38648751
HTRA3Human3,3',5,5'-tetrabromobisphenol A decreases expressionISOHtra3 (Mus musculus)6480464tetrabromobisphenol A results in decreased expression of HTRA3 mRNACTDPMID:25172293
HTRA3Human3,7-dihydropurine-6-thione increases expressionISOHtra3 (Rattus norvegicus)6480464Mercaptopurine results in increased expression of HTRA3 mRNACTDPMID:23358152
HTRA3Human3-chloropropane-1,2-diol increases expressionISOHtra3 (Rattus norvegicus)6480464alpha-Chlorohydrin results in increased expression of HTRA3 mRNACTDPMID:28522335
HTRA3Human4,4'-sulfonyldiphenol increases methylationISOHtra3 (Mus musculus)6480464bisphenol S results in increased methylation of HTRA3 exon and bisphenol S results in increased methylation of HTRA3 promoterCTDPMID:33297965
HTRA3Human4,4'-sulfonyldiphenol affects methylationISOHtra3 (Mus musculus)6480464bisphenol S affects the methylation of HTRA3 geneCTDPMID:31683443
HTRA3Human4-hydroxyphenyl retinamide decreases expressionISOHtra3 (Mus musculus)6480464Fenretinide results in decreased expression of HTRA3 mRNACTDPMID:28973697
HTRA3HumanAflatoxin B2 alpha increases methylationEXP 6480464aflatoxin B2 results in increased methylation of HTRA3 intronCTDPMID:30157460
HTRA3HumanAflatoxin B2 alpha decreases methylationEXP 6480464aflatoxin B2 results in decreased methylation of HTRA3 polyA tailCTDPMID:30157460
HTRA3Humanaldehydo-D-glucose multiple interactionsISOHtra3 (Mus musculus)6480464[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of HTRA3 mRNACTDPMID:37567420
HTRA3Humanantirheumatic drug increases expressionEXP 6480464Antirheumatic Agents results in increased expression of HTRA3 mRNACTDPMID:24449571
HTRA3Humanaristolochic acid A increases expressionEXP 6480464aristolochic acid I results in increased expression of HTRA3 mRNACTDPMID:33212167
HTRA3Humanarsane multiple interactionsEXP 6480464[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of HTRA3 mRNACTDPMID:39836092

1 to 20 of 103 rows

Biological Process
1 to 9 of 9 rows

  
1 to 9 of 9 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HTRA3Humanextracellular region located_inIEAInterPro:IPR000867150520179 InterProGO_REF:0000002
HTRA3Humanextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
HTRA3Humanextracellular region located_inIEAUniProtKB-SubCell:SL-0243150520179 UniProtGO_REF:0000044

Molecular Function
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HTRA3Humanendopeptidase activity enablesIDA 150520179 PMID:18387192BHF-UCLPMID:18387192
HTRA3Humanhydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
HTRA3Humanidentical protein binding enablesIPIUniProtKB:P83110150520179 PMID:26110759 and PMID:31899476IntActPMID:26110759 and PMID:31899476
HTRA3Humanidentical protein binding enablesIPIUniProtKB:P83110-1150520179 PMID:28642151IntActPMID:28642151
HTRA3Humanpeptidase activity enablesIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
HTRA3Humanprotein binding enablesIPIUniProtKB:P98170150520179 PMID:28642151 and PMID:31260151IntActPMID:28642151 and PMID:31260151
HTRA3Humanprotein binding enablesIPIUniProtKB:P02666 and UniProtKB:P98170150520179 PMID:31470122IntActPMID:31470122
HTRA3Humanprotein binding enablesIPIUniProtKB:P83105150520179 PMID:25002585IntActPMID:25002585
HTRA3Humanprotein binding enablesIPIUniProtKB:P35579150520179 PMID:22229724UniProtPMID:22229724
HTRA3Humanprotein binding enablesIPIUniProtKB:P08670 more ...150520179 PMID:29477555IntActPMID:29477555
HTRA3Humanprotein binding enablesIPIUniProtKB:P02666150520179 PMID:26110759 and PMID:31899476IntActPMID:26110759 and PMID:31899476
HTRA3Humanserine-type endopeptidase activity enablesIEAInterPro:IPR001940150520179 InterProGO_REF:0000002
HTRA3Humanserine-type endopeptidase activity enablesIBAFB:FBgn0038233 more ...150520179 GO_CentralGO_REF:0000033
HTRA3Humanserine-type peptidase activity enablesIEAUniProtKB-KW:KW-0720150520179 UniProtGO_REF:0000043
HTRA3Humanserine-type peptidase activity enablesIEAUniProtKB:Q9D236 and ensembl:ENSMUSP00000084910150520179 EnsemblGO_REF:0000107
HTRA3Humanserine-type peptidase activity enablesIDA 150520179 PMID:22229724UniProtPMID:22229724
1 to 16 of 16 rows


#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Transcriptome analysis of bronchoalveolar lavage fluid from children with severe Mycoplasma pneumoniae pneumonia reveals novel gene expression and immunodeficiency. Wang K, etal., Hum Genomics. 2017 Mar 16;11(1):4. doi: 10.1186/s40246-017-0101-y.
PMID:12477932   PMID:12513693   PMID:14500695   PMID:15489334   PMID:16251496   PMID:16650464   PMID:17962403   PMID:18241672   PMID:18387192   PMID:19359045   PMID:19424634   PMID:19951697  
PMID:20068077   PMID:20154083   PMID:20379614   PMID:20469960   PMID:21035848   PMID:21047919   PMID:21321049   PMID:21555518   PMID:21873635   PMID:22229724   PMID:22923201   PMID:23049902  
PMID:23812730   PMID:25002585   PMID:25274382   PMID:25456008   PMID:26110759   PMID:26186194   PMID:27166271   PMID:28514442   PMID:28642151   PMID:28676687   PMID:28700943   PMID:28716573  
PMID:28860718   PMID:29266444   PMID:29477555   PMID:29845934   PMID:30139517   PMID:30940659   PMID:31013509   PMID:31180543   PMID:31260151   PMID:31280864   PMID:31470122   PMID:31586073  
PMID:31899476   PMID:32486357   PMID:33462352   PMID:33864728   PMID:33961781   PMID:35035835   PMID:35869629   PMID:37606164   PMID:37842043  



HTRA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3848,269,754 - 8,307,098 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl48,269,754 - 8,307,098 (+)EnsemblGRCh38hg38GRCh38
GRCh3748,271,481 - 8,308,825 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3648,322,392 - 8,359,734 (+)NCBINCBI36Build 36hg18NCBI36
Build 3448,389,562 - 8,426,901NCBI
Celera48,163,395 - 8,202,090 (+)NCBICelera
Cytogenetic Map4p16.1NCBI
HuRef48,191,265 - 8,229,449 (+)NCBIHuRef
CHM1_148,269,374 - 8,307,228 (+)NCBICHM1_1
T2T-CHM13v2.048,248,531 - 8,287,062 (+)NCBIT2T-CHM13v2.0
Htra3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39535,809,370 - 35,837,157 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl535,809,367 - 35,837,126 (-)EnsemblGRCm39 Ensembl
GRCm38535,652,026 - 35,679,813 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl535,652,023 - 35,679,782 (-)EnsemblGRCm38mm10GRCm38
MGSCv37535,994,682 - 36,022,431 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36535,968,902 - 35,996,426 (-)NCBIMGSCv36mm8
Celera533,125,477 - 33,153,277 (-)NCBICelera
Cytogenetic Map5B3NCBI
cM Map518.49NCBI
Htra3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81479,293,535 - 79,321,936 (+)NCBIGRCr8
mRatBN7.21475,068,917 - 75,097,315 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,068,917 - 75,097,315 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1479,510,244 - 79,538,637 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01480,751,106 - 80,779,496 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,196,098 - 77,224,488 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01480,248,140 - 80,276,534 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1480,248,140 - 80,276,534 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01479,875,405 - 79,903,558 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41480,702,016 - 80,730,742 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11480,704,572 - 80,732,620 (+)NCBI
Celera1473,999,661 - 74,027,836 (+)NCBICelera
Cytogenetic Map14q21NCBI
Htra3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555142,717,290 - 2,737,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555142,716,448 - 2,740,590 (-)NCBIChiLan1.0ChiLan1.0
HTRA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v238,555,658 - 8,594,262 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan148,482,892 - 8,521,742 (+)NCBINHGRI_mPanPan1
PanPan1.148,335,529 - 8,374,509 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl48,335,529 - 8,374,510 (+)Ensemblpanpan1.1panPan2
HTRA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1360,081,087 - 60,111,847 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl360,081,087 - 60,111,170 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha362,729,083 - 62,759,944 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0360,553,415 - 60,587,493 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl360,553,106 - 60,586,818 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1360,048,935 - 60,079,759 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0360,252,174 - 60,283,033 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0360,610,012 - 60,640,894 (+)NCBIUU_Cfam_GSD_1.0
Htra3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528565,923,787 - 65,960,840 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647719,646,047 - 19,661,632 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647719,625,479 - 19,662,532 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTRA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl82,793,799 - 2,820,184 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.182,794,780 - 2,819,686 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.284,457,177 - 4,482,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HTRA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12744,214,635 - 44,252,673 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2744,214,874 - 44,252,732 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666051545,096 - 583,900 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htra3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475523,951,134 - 23,969,774 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475523,950,972 - 23,969,700 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in HTRA3
40 total Variants

1 to 10 of 137 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 4p16.3-15.1(chr4:72555-28066309)x1 copy number loss See cases [RCV000051642] Chr4:72555..28066309 [GRCh38]
Chr4:72447..28067931 [GRCh37]
Chr4:62447..27677029 [NCBI36]
Chr4:4p16.3-15.1		 pathogenic
GRCh38/hg38 4p16.3-15.33(chr4:56878-14499760)x1 copy number loss See cases [RCV000051614] Chr4:56878..14499760 [GRCh38]
Chr4:56772..14501384 [GRCh37]
Chr4:46772..14110482 [NCBI36]
Chr4:4p16.3-15.33		 pathogenic
GRCh38/hg38 4p16.3-15.2(chr4:85149-22450018)x3 copy number gain See cases [RCV000051755] Chr4:85149..22450018 [GRCh38]
Chr4:85040..22451641 [GRCh37]
Chr4:75040..22060739 [NCBI36]
Chr4:4p16.3-15.2		 pathogenic
GRCh38/hg38 4p16.3-15.33(chr4:72555-11610824)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051674]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051674]|See cases [RCV000051674] Chr4:72555..11610824 [GRCh38]
Chr4:72447..11612448 [GRCh37]
Chr4:62447..11221546 [NCBI36]
Chr4:4p16.3-15.33		 pathogenic
GRCh38/hg38 4p16.3-15.32(chr4:85149-17486742)x1 copy number loss See cases [RCV000051679] Chr4:85149..17486742 [GRCh38]
Chr4:85040..17488365 [GRCh37]
Chr4:75040..17097463 [NCBI36]
Chr4:4p16.3-15.32		 pathogenic
GRCh38/hg38 4p16.3-16.1(chr4:51319-10250807)x3 copy number gain See cases [RCV000051743] Chr4:51319..10250807 [GRCh38]
Chr4:51213..10252431 [GRCh37]
Chr4:41213..9861529 [NCBI36]
Chr4:4p16.3-16.1		 pathogenic
GRCh38/hg38 4p16.3-15.2(chr4:51519-26519788)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051752]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051752]|See cases [RCV000051752] Chr4:51519..26519788 [GRCh38]
Chr4:51413..26521410 [GRCh37]
Chr4:41413..26130508 [NCBI36]
Chr4:4p16.3-15.2		 pathogenic
GRCh38/hg38 4p16.3-15.1(chr4:72555-33130620)x3 copy number gain See cases [RCV000051753] Chr4:72555..33130620 [GRCh38]
Chr4:72447..33132242 [GRCh37]
Chr4:62447..32808637 [NCBI36]
Chr4:4p16.3-15.1		 pathogenic
GRCh38/hg38 4p16.3-14(chr4:85149-38700366)x3 copy number gain See cases [RCV000051757] Chr4:85149..38700366 [GRCh38]
Chr4:85040..38701987 [GRCh37]
Chr4:75040..38378382 [NCBI36]
Chr4:4p16.3-14		 pathogenic
GRCh38/hg38 4p16.3-16.1(chr4:72555-10004195)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051672]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051672]|See cases [RCV000051672] Chr4:72555..10004195 [GRCh38]
Chr4:72447..10005819 [GRCh37]
Chr4:62447..9614917 [NCBI36]
Chr4:4p16.3-16.1		 pathogenic
1 to 10 of 137 rows

Predicted Target Of
Summary Value
Count of predictions:939
Count of miRNA genes:590
Interacting mature miRNAs:667
Transcripts:ENST00000307358, ENST00000382512
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597307410GWAS1403484_Hretinal vasculature measurement QTL GWAS1403484 (human)8e-27retina blood vessel morphology trait (VT:0002792)482733778273378Human
597201364GWAS1297438_Hpulse pressure measurement QTL GWAS1297438 (human)0.000005pulse pressure measurementpulse pressure (CMO:0000292)482914668291467Human

WI-12525  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3748,298,067 - 8,298,173UniSTSGRCh37
Build 3648,348,967 - 8,349,073RGDNCBI36
Celera48,191,243 - 8,191,349RGD
Cytogenetic Map4p16.1UniSTS
HuRef48,218,696 - 8,218,802UniSTS
GeneMap99-GB4 RH Map453.96UniSTS
Whitehead-RH Map449.0UniSTS
RH80395  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3748,308,571 - 8,308,789UniSTSGRCh37
Build 3648,359,471 - 8,359,689RGDNCBI36
Celera48,201,827 - 8,202,045RGD
Cytogenetic Map4p16.1UniSTS
HuRef48,229,182 - 8,229,400UniSTS
A007I17  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3748,297,926 - 8,298,171UniSTSGRCh37
Build 3648,348,826 - 8,349,071RGDNCBI36
Celera48,191,102 - 8,191,347RGD
Cytogenetic Map4p16.1UniSTS
HuRef48,218,555 - 8,218,800UniSTS
GeneMap99-GB4 RH Map455.78UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2358 2788 2231 4905 1712 2294 3 620 1711 461 2244 6982 6226 36 3688 832 1708 1563 170



Ensembl Acc Id: ENST00000307358   ⟹   ENSP00000303766
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl48,269,754 - 8,307,098 (+)Ensembl
Ensembl Acc Id: ENST00000382512   ⟹   ENSP00000371952
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl48,269,777 - 8,296,474 (+)Ensembl
RefSeq Acc Id: NM_001297559   ⟹   NP_001284488
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3848,269,754 - 8,296,478 (+)NCBI
CHM1_148,269,377 - 8,296,652 (+)NCBI
T2T-CHM13v2.048,248,531 - 8,276,441 (+)NCBI
Sequence:
RefSeq Acc Id: NM_053044   ⟹   NP_444272
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3848,269,754 - 8,307,098 (+)NCBI
GRCh3748,271,487 - 8,308,838 (+)NCBI
Build 3648,322,392 - 8,359,734 (+)NCBI Archive
HuRef48,191,265 - 8,229,449 (+)ENTREZGENE
CHM1_148,269,377 - 8,307,228 (+)NCBI
T2T-CHM13v2.048,248,531 - 8,287,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011513596   ⟹   XP_011511898
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3848,269,754 - 8,296,478 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054351282   ⟹   XP_054207257
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.048,248,531 - 8,276,441 (+)NCBI
RefSeq Acc Id: NP_444272   ⟸   NM_053044
- Peptide Label: isoform 1 precursor
- UniProtKB: Q7Z7A2 (UniProtKB/Swiss-Prot),   P83110 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001284488   ⟸   NM_001297559
- Peptide Label: isoform 2 precursor
- UniProtKB: P83110 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011511898   ⟸   XM_011513596
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSP00000303766   ⟸   ENST00000307358
Ensembl Acc Id: ENSP00000371952   ⟸   ENST00000382512
IGFBP N-terminal   Kazal-like   PDZ

Name Modeler Protein Id AA Range Protein Structure
AF-P83110-F1-model_v2 AlphaFold P83110 1-453 view protein structure

RGD ID:6867010
Promoter ID:EPDNEW_H6670
Type:multiple initiation site
Name:HTRA3_1
Description:HtrA serine peptidase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3848,269,754 - 8,269,814EPDNEW
RGD ID:6802372
Promoter ID:HG_KWN:47830
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:ENST00000307358,   UC003GKZ.2
Position:
Human AssemblyChrPosition (strand)Source
Build 3648,322,171 - 8,322,671 (+)MPROMDB


1 to 40 of 45 rows
Database
Acc Id
Source(s)
COSMIC HTRA3 COSMIC
Ensembl Genes ENSG00000170801 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000307358 ENTREZGENE
  ENST00000307358.7 UniProtKB/Swiss-Prot
  ENST00000382512 ENTREZGENE
  ENST00000382512.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
  2.40.10.120 UniProtKB/Swiss-Prot
  3.30.60.30 UniProtKB/Swiss-Prot
  4.10.40.20 UniProtKB/Swiss-Prot
GTEx ENSG00000170801 GTEx
HGNC ID HGNC:30406 ENTREZGENE
Human Proteome Map HTRA3 Human Proteome Map
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  IGFBP-like UniProtKB/Swiss-Prot
  Kazal_dom UniProtKB/Swiss-Prot
  Kazal_dom_sf UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1C UniProtKB/Swiss-Prot
KEGG Report hsa:94031 UniProtKB/Swiss-Prot
NCBI Gene 94031 ENTREZGENE
OMIM 608785 OMIM
PANTHER SERINE PROTEASE FAMILY S1C HTRA-RELATED UniProtKB/Swiss-Prot
  SERINE PROTEASE HTRA3 UniProtKB/Swiss-Prot
Pfam IGFBP UniProtKB/Swiss-Prot
  Kazal_2 UniProtKB/Swiss-Prot
  PDZ_2 UniProtKB/Swiss-Prot
  Trypsin_2 UniProtKB/Swiss-Prot
PharmGKB PA134908281 PharmGKB
PRINTS PROTEASES2C UniProtKB/Swiss-Prot
PROSITE IGFBP_N_2 UniProtKB/Swiss-Prot
  KAZAL_2 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
SMART KAZAL UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SM00121 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
1 to 40 of 45 rows