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Gene: HTRA3 (HtrA serine peptidase 3) Homo sapiens
Symbol: HTRA3
Name: HtrA serine peptidase 3
Description: Exhibits endopeptidase activity; identical protein binding activity; and serine-type peptidase activity. Involved in proteolysis. Predicted to localize to extracellular region; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B2.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: high-temperature requirement factor A3; pregnancy-related serine protease; probable serine protease HTRA3; Prsp; serine protease HTRA3; Tasp
Mus musculus (house mouse) : Htra3 (HtrA serine peptidase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Htra3 (HtrA serine peptidase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htra3 (HtrA serine peptidase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : HTRA3 (HtrA serine peptidase 3)
Canis lupus familiaris (dog) : HTRA3 (HtrA serine peptidase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htra3 (HtrA serine peptidase 3)
Sus scrofa (pig) : HTRA3 (HtrA serine peptidase 3)
Chlorocebus sabaeus (African green monkey) : HTRA3 (HtrA serine peptidase 3)
Heterocephalus glaber (naked mole-rat) : Htra3 (HtrA serine peptidase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl48,269,754 - 8,307,098 (+)EnsemblGRCh38hg38GRCh38
GRCh3848,269,712 - 8,307,098 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3748,271,487 - 8,308,838 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3648,322,392 - 8,359,734 (+)NCBINCBI36hg18NCBI36
Build 3448,389,562 - 8,426,901NCBI
Celera48,163,395 - 8,202,090 (+)NCBI
Cytogenetic Map4p16.1NCBI
HuRef48,191,265 - 8,229,449 (+)NCBIHuRef
CHM1_148,269,377 - 8,307,228 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HTRA3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1354015
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.