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Gene: Htra3 (HtrA serine peptidase 3) Ictidomys tridecemlineatus

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Symbol:

Htra3

Name:

HtrA serine peptidase 3

RGD ID:

12650376

Description:

ENCODES a protein that exhibits endopeptidase activity (inferred); hydrolase activity (inferred); identical protein binding (inferred); INVOLVED IN negative regulation of BMP signaling pathway (inferred); negative regulation of transforming growth factor beta receptor signaling pathway (inferred); proteolysis (inferred); ASSOCIATED WITH Mycoplasma pneumoniae pneumonia (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

serine protease HTRA3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HTRA3 (HtrA serine peptidase 3)	NCBI	Ortholog
Mus musculus (house mouse):	Htra3 (HtrA serine peptidase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Htra3 (HtrA serine peptidase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Htra3 (HtrA serine peptidase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HTRA3 (HtrA serine peptidase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HTRA3 (HtrA serine peptidase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HTRA3 (HtrA serine peptidase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HTRA3 (HtrA serine peptidase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Htra3 (HtrA serine peptidase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	65,923,787 - 65,960,840 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	19,646,047 - 19,661,632 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	19,625,479 - 19,662,532 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Htra3	Squirrel	Mycoplasma pneumoniae pneumonia	severity	ISO	RGD:1354015	9068941		RGD	PMID:28302172\|REF_RGD_ID:32716376

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Htra3	Squirrel	negative regulation of BMP signaling pathway	involved_in	IEA	UniProtKB:Q9D236\|ensembl:ENSMUSP00000084910	150520179		Ensembl	GO_REF:0000107
Htra3	Squirrel	negative regulation of transforming growth factor beta receptor signaling pathway	involved_in	IEA	UniProtKB:Q9D236\|ensembl:ENSMUSP00000084910	150520179		Ensembl	GO_REF:0000107
Htra3	Squirrel	proteolysis	involved_in	IEA	PANTHER:PTN000533738	150520179		TreeGrafter	GO_REF:0000118
Htra3	Squirrel	proteolysis	involved_in	IEA	InterPro:IPR001940	150520179		InterPro	GO_REF:0000002
Htra3	Squirrel	proteolysis	involved_in	IEA	UniProtKB-KW:KW-0645	150520179		UniProt	GO_REF:0000043
Htra3	Squirrel	proteolysis	involved_in	IEA	UniProtKB:P83110\|UniProtKB:Q9D236\|ensembl:ENSMUSP00000084910\|ensembl:ENSP00000303766	150520179		Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Htra3	Squirrel	endopeptidase activity	enables	IEA	UniProtKB:P83110\|ensembl:ENSP00000303766	150520179		Ensembl	GO_REF:0000107
Htra3	Squirrel	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	150520179		UniProt	GO_REF:0000043
Htra3	Squirrel	identical protein binding	enables	IEA	UniProtKB:P83110\|ensembl:ENSP00000303766	150520179		Ensembl	GO_REF:0000107
Htra3	Squirrel	peptidase activity	enables	IEA	UniProtKB-KW:KW-0645	150520179		UniProt	GO_REF:0000043
Htra3	Squirrel	protein binding	enables	ISO	UniProtKB:P83105	9068941	PMID:25002585	IntAct	PMID:25002585
Htra3	Squirrel	protein binding	enables	ISO	UniProtKB:P04202\|UniProtKB:P21275\|UniProtKB:P27090\|UniProtKB:P43027	9068941	PMID:15206957	UniProt	PMID:15206957
Htra3	Squirrel	protein binding	enables	ISO	UniProtKB:P98170	9068941	PMID:28642151, PMID:31260151	IntAct	PMID:28642151\|PMID:31260151
Htra3	Squirrel	protein binding	enables	ISO	UniProtKB:P08670\|UniProtKB:P17987\|UniProtKB:P60709	9068941	PMID:29477555	IntAct	PMID:29477555
Htra3	Squirrel	protein binding	enables	ISO	UniProtKB:P02666	9068941	PMID:26110759, PMID:31899476	IntAct	PMID:26110759\|PMID:31899476
Htra3	Squirrel	protein binding	enables	ISO	UniProtKB:P02666\|UniProtKB:P98170	9068941	PMID:31470122	IntAct	PMID:31470122
Htra3	Squirrel	protein binding	enables	ISO	UniProtKB:P35579	9068941	PMID:22229724	UniProt	PMID:22229724
Htra3	Squirrel	serine-type endopeptidase activity	enables	IEA	PANTHER:PTN000533738	150520179		TreeGrafter	GO_REF:0000118
Htra3	Squirrel	serine-type endopeptidase activity	enables	IEA	InterPro:IPR001940	150520179		InterPro	GO_REF:0000002
Htra3	Squirrel	serine-type peptidase activity	enables	IEA	UniProtKB:P83110\|UniProtKB:Q9D236\|ensembl:ENSMUSP00000084910\|ensembl:ENSP00000303766	150520179		Ensembl	GO_REF:0000107

PMID:22301074

Htra3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	65,923,787 - 65,960,840 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	19,646,047 - 19,661,632 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	19,625,479 - 19,662,532 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HTRA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	8,269,754 - 8,307,098 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	8,269,754 - 8,307,098 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	8,271,481 - 8,308,825 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	8,322,392 - 8,359,734 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	8,389,562 - 8,426,901	NCBI
Celera	4	8,163,395 - 8,202,090 (+)	NCBI		Celera
Cytogenetic Map	4	p16.1	NCBI
HuRef	4	8,191,265 - 8,229,449 (+)	NCBI		HuRef
CHM1_1	4	8,269,374 - 8,307,228 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	8,248,531 - 8,287,062 (+)	NCBI		T2T-CHM13v2.0

Htra3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	35,809,370 - 35,837,157 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	35,809,367 - 35,837,126 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	35,652,026 - 35,679,813 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	35,652,023 - 35,679,782 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	35,994,682 - 36,022,431 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	35,968,902 - 35,996,426 (-)	NCBI		MGSCv36	mm8
Celera	5	33,125,477 - 33,153,277 (-)	NCBI		Celera
Cytogenetic Map	5	B3	NCBI
cM Map	5	18.49	NCBI

Htra3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	79,293,535 - 79,321,936 (+)	NCBI		GRCr8
mRatBN7.2	14	75,068,917 - 75,097,315 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	75,068,917 - 75,097,315 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	79,510,244 - 79,538,637 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	80,751,106 - 80,779,496 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	77,196,098 - 77,224,488 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	80,248,140 - 80,276,534 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	80,248,140 - 80,276,534 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	79,875,405 - 79,903,558 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	80,702,016 - 80,730,742 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	80,704,572 - 80,732,620 (+)	NCBI
Celera	14	73,999,661 - 74,027,836 (+)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

Htra3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	2,717,290 - 2,737,288 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955514	2,716,448 - 2,740,590 (-)	NCBI	ChiLan1.0	ChiLan1.0

HTRA3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	8,555,658 - 8,594,262 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	8,482,892 - 8,521,742 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	4	8,335,529 - 8,374,509 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	8,335,529 - 8,374,510 (+)	Ensembl	panpan1.1		panPan2

HTRA3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	60,081,087 - 60,111,847 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	60,081,087 - 60,111,170 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	62,729,083 - 62,759,944 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	60,553,415 - 60,587,493 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	60,553,106 - 60,586,818 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	60,048,935 - 60,079,759 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	60,252,174 - 60,283,033 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	60,610,012 - 60,640,894 (+)	NCBI		UU_Cfam_GSD_1.0

HTRA3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	2,793,799 - 2,820,184 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	2,794,780 - 2,819,686 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	4,457,177 - 4,482,055 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HTRA3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	44,214,635 - 44,252,673 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	44,214,874 - 44,252,732 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666051	545,096 - 583,900 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Htra3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	23,951,134 - 23,969,774 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624755	23,950,972 - 23,969,700 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_021722213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040292141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000028006 ⟹ ENSSTOP00000015566

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936477	19,646,047 - 19,661,632 (+)	Ensembl

RefSeq Acc Id:

XM_040292141 ⟹ XP_040148075

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405285	65,923,787 - 65,960,840 (+)	NCBI


Protein RefSeqs	XP_040148075	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000015566.2
GenBank Protein	KAG3276970	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_040148075 ⟸ XM_040292141

Ensembl Acc Id:

ENSSTOP00000015566 ⟸ ENSSTOT00000028006

Protein Domains

PDZ

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000021150	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000028006.2	UniProtKB/TrEMBL
Gene3D-CATH	2.30.42.10	UniProtKB/TrEMBL
	2.40.10.120	UniProtKB/TrEMBL
InterPro	PDZ	UniProtKB/TrEMBL
	PDZ_sf	UniProtKB/TrEMBL
	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1C	UniProtKB/TrEMBL
NCBI Gene	Htra3	ENTREZGENE
PANTHER	SERINE PROTEASE FAMILY S1C HTRA-RELATED	UniProtKB/TrEMBL
	SERINE PROTEASE HTRA3	UniProtKB/TrEMBL
Pfam	PDZ_2	UniProtKB/TrEMBL
	Trypsin_2	UniProtKB/TrEMBL
PRINTS	PROTEASES2C	UniProtKB/TrEMBL
PROSITE	PDZ	UniProtKB/TrEMBL
SMART	PDZ	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50156	UniProtKB/TrEMBL
	SSF50494	UniProtKB/TrEMBL
UniProt	I3MTX1_ICTTR	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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