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Gene: GHRL (ghrelin and obestatin prepropeptide) Homo sapiens
Symbol: GHRL
Name: ghrelin and obestatin prepropeptide
Description: Exhibits protein tyrosine kinase activator activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of hormone secretion; and regulation of circadian sleep/wake cycle, sleep. Localizes to the axon and extracellular space. Implicated in diabetic neuropathy; morbid obesity; obesity; and type 2 diabetes mellitus. Biomarker of Prader-Willi syndrome; cardiovascular system disease; and end stage renal failure.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: appetite-regulating hormone; ghrelin precursor; ghrelin, growth hormone secretagogue receptor ligand; ghrelin/obestatin preprohormone; ghrelin/obestatin prepropeptide; growth hormone secretagogue; growth hormone-releasing peptide; In2c-preproghrelin; motilin-related peptide; MTLRP; obestatin; prepro-appetite regulatory hormone; preproghrelin
Mus musculus (house mouse) : Ghrl (ghrelin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ghrl (ghrelin and obestatin prepropeptide)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ghrl (ghrelin and obestatin prepropeptide)
Pan paniscus (bonobo/pygmy chimpanzee) : GHRL (ghrelin and obestatin prepropeptide)
Canis lupus familiaris (dog) : GHRL (ghrelin and obestatin prepropeptide)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ghrl (ghrelin and obestatin prepropeptide)
Sus scrofa (pig) : GHRL (ghrelin and obestatin prepropeptide)
Chlorocebus sabaeus (African green monkey) : GHRL (ghrelin and obestatin prepropeptide)
Heterocephalus glaber (naked mole-rat) : Ghrl (ghrelin and obestatin prepropeptide)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl310,285,666 - 10,292,947 (-)Ensembl
GRCh38310,285,666 - 10,292,947 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37310,327,434 - 10,334,631 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36310,302,434 - 10,307,409 (-)NCBINCBI36hg18NCBI36
Build 34310,302,433 - 10,307,409NCBI
Celera310,263,242 - 10,270,439 (-)NCBI
Cytogenetic Map3p25.3NCBI
HuRef310,262,844 - 10,269,999 (-)NCBIHuRef
CHM1_1310,277,571 - 10,284,767 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GHRL
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730950
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.