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Gene: GREM1 (gremlin 1, DAN family BMP antagonist) Homo sapiens
Symbol: GREM1
Name: gremlin 1, DAN family BMP antagonist
Description: Exhibits BMP binding activity and protein homodimerization activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of ossification; and negative regulation of signal transduction. Localizes to collagen-containing extracellular matrix.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C15DUPq; cell proliferation-inducing gene 2 protein; CKTSF1B1; colorectal adenoma and carcinoma 1; CRAC1; CRCS4; cysteine knot superfamily 1, BMP antagonist 1; DAN domain family member 2; DAND2; down-regulated in Mos-transformed cells protein; DRM; DUP15q; GREMLIN; gremlin 1, cysteine knot superfamily, homolog; gremlin 1-like protein; gremlin-1; hereditary mixed polyposis syndrome; HMPS; HMPS1; IHG-2; increased in high glucose protein 2; increased in high glucose-2; MGC126660; MPSH; PIG2; proliferation-inducing gene 2
Mus musculus (house mouse) : Grem1 (gremlin 1, DAN family BMP antagonist)  MGI  Alliance
Rattus norvegicus (Norway rat) : Grem1 (gremlin 1, DAN family BMP antagonist)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grem1 (gremlin 1, DAN family BMP antagonist)
Pan paniscus (bonobo/pygmy chimpanzee) : GREM1 (gremlin 1, DAN family BMP antagonist)
Canis lupus familiaris (dog) : GREM1 (gremlin 1, DAN family BMP antagonist)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grem1 (gremlin 1, DAN family BMP antagonist)
Sus scrofa (pig) : GREM1 (gremlin 1, DAN family BMP antagonist)
Chlorocebus sabaeus (African green monkey) : GREM1 (gremlin 1, DAN family BMP antagonist)
Heterocephalus glaber (naked mole-rat) : Grem1 (gremlin 1, DAN family BMP antagonist)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1532,718,004 - 32,745,106 (+)EnsemblGRCh38hg38GRCh38
GRCh381532,718,004 - 32,745,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371533,010,175 - 33,026,870 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361530,797,497 - 30,814,158 (+)NCBINCBI36hg18NCBI36
Build 341530,797,593 - 30,814,158NCBI
Celera159,812,058 - 9,828,720 (+)NCBI
Cytogenetic Map15q13.3NCBI
HuRef159,872,067 - 9,888,724 (+)NCBIHuRef
CHM1_11533,128,259 - 33,144,912 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GREM1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346462
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.