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Gene: ZIC3 (Zic family member 3) Homo sapiens
Symbol: ZIC3
Name: Zic family member 3
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in determination of left/right symmetry; lung development; and positive regulation of transcription by RNA polymerase II. Localizes to nucleoplasm. Implicated in X-linked VACTERL association; situs inversus; and visceral heterotaxy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: heterotaxy 1; HTX; HTX1; VACTERLX; Zic family member 3 (odd-paired homolog, Drosophila); zinc finger protein 203; zinc finger protein of the cerebellum 3; zinc finger protein ZIC 3; ZNF203
Mus musculus (house mouse) : Zic3 (zinc finger protein of the cerebellum 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Zic3 (Zic family member 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Zic3 (Zic family member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ZIC3 (Zic family member 3)
Canis lupus familiaris (dog) : ZIC3 (Zic family member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Zic3 (Zic family member 3)
Sus scrofa (pig) : ZIC3 (Zic family member 3)
Chlorocebus sabaeus (African green monkey) : ZIC3 (Zic family member 3)
Heterocephalus glaber (naked mole-rat) : Zic3 (Zic family member 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX137,566,127 - 137,577,691 (+)EnsemblGRCh38hg38GRCh38
GRCh38X137,566,127 - 137,577,691 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X136,648,346 - 136,654,259 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X136,476,012 - 136,481,925 (+)NCBINCBI36hg18NCBI36
Build 34X136,373,865 - 136,379,777NCBI
CeleraX137,014,356 - 137,020,269 (+)NCBI
Cytogenetic MapXq26.3NCBI
HuRefX125,916,990 - 125,922,902 (+)NCBIHuRef
CHM1_1X136,559,744 - 136,565,657 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ZIC3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1347201
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-04-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.