GDF9 (growth differentiation factor 9) - Rat Genome Database

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Gene: GDF9 (growth differentiation factor 9) Homo sapiens
Analyze
Symbol: GDF9
Name: growth differentiation factor 9
RGD ID: 736579
HGNC Page HGNC
Description: Predicted to enable cytokine activity and type I activin receptor binding activity. Involved in positive regulation of cell population proliferation and regulation of progesterone secretion. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in extracellular space. Implicated in primary ovarian insufficiency 14.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GDF-9; growth/differentiation factor 9; POF14
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5132,861,181 - 132,866,884 (-)EnsemblGRCh38hg38GRCh38
GRCh385132,861,181 - 132,866,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375132,196,877 - 132,202,576 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,224,777 - 132,228,376 (-)NCBINCBI36hg18NCBI36
Build 345132,225,179 - 132,228,124NCBI
Celera5128,326,902 - 128,330,501 (-)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5127,389,594 - 127,393,194 (-)NCBIHuRef
CHM1_15131,630,163 - 131,633,762 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Additional References at PubMed
PMID:7760846   PMID:8429021   PMID:8849725   PMID:9564873   PMID:10067849   PMID:10443672   PMID:10712517   PMID:11056243   PMID:11376106   PMID:11604237   PMID:11788667   PMID:11889206  
PMID:12050262   PMID:12135884   PMID:12446716   PMID:12477932   PMID:12574210   PMID:14970198   PMID:15372022   PMID:15383276   PMID:15489334   PMID:15607004   PMID:16169070   PMID:16278619  
PMID:16344560   PMID:16603567   PMID:16645022   PMID:16954162   PMID:17027369   PMID:17156781   PMID:17453295   PMID:17482612   PMID:18006624   PMID:18063682   PMID:18162287   PMID:18633140  
PMID:18854109   PMID:19111296   PMID:19366876   PMID:19376510   PMID:19423755   PMID:19438907   PMID:19505950   PMID:19846738   PMID:19931079   PMID:20067794   PMID:20236105   PMID:20237496  
PMID:20427239   PMID:20451184   PMID:20458753   PMID:20547206   PMID:20660033   PMID:20705511   PMID:20734064   PMID:21042764   PMID:21116689   PMID:21226076   PMID:21496799   PMID:21632818  
PMID:21669410   PMID:21829661   PMID:21873635   PMID:21900206   PMID:21970812   PMID:22159313   PMID:22234469   PMID:22825968   PMID:23011157   PMID:23060562   PMID:23382188   PMID:23523567  
PMID:23567549   PMID:23650403   PMID:23851219   PMID:24413384   PMID:24430093   PMID:24438375   PMID:24840335   PMID:24939957   PMID:25139161   PMID:25155366   PMID:25172094   PMID:25253739  
PMID:25368253   PMID:25954833   PMID:26254468   PMID:27035733   PMID:27855376   PMID:28346732   PMID:28514442   PMID:28762037   PMID:28831646   PMID:29044499   PMID:29544636   PMID:30021884  
PMID:30039232   PMID:30060157   PMID:30851298   PMID:31392662   PMID:31586073   PMID:31996061   PMID:32350111  


Genomics

Comparative Map Data
GDF9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5132,861,181 - 132,866,884 (-)EnsemblGRCh38hg38GRCh38
GRCh385132,861,181 - 132,866,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375132,196,877 - 132,202,576 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,224,777 - 132,228,376 (-)NCBINCBI36hg18NCBI36
Build 345132,225,179 - 132,228,124NCBI
Celera5128,326,902 - 128,330,501 (-)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5127,389,594 - 127,393,194 (-)NCBIHuRef
CHM1_15131,630,163 - 131,633,762 (-)NCBICHM1_1
Gdf9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,321,773 - 53,328,731 (+)NCBIGRCm39mm39
GRCm39 Ensembl1153,321,850 - 53,328,731 (+)Ensembl
GRCm381153,430,774 - 53,437,904 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,431,023 - 53,437,904 (+)EnsemblGRCm38mm10GRCm38
MGSCv371153,246,788 - 53,251,405 (+)NCBIGRCm37mm9NCBIm37
MGSCv361153,276,801 - 53,281,323 (+)NCBImm8
Celera1158,013,006 - 58,017,623 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.94NCBI
Gdf9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21037,589,200 - 37,599,970 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1037,595,679 - 37,599,672 (+)Ensembl
Rnor_6.01038,782,519 - 38,793,238 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,788,992 - 38,792,940 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,564,774 - 38,574,967 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41038,899,125 - 38,903,073 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11038,905,554 - 38,909,503 (+)NCBI
Celera1036,942,737 - 36,946,686 (+)NCBICelera
Cytogenetic Map10q22NCBI
Gdf9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554084,234,208 - 4,239,795 (-)NCBIChiLan1.0ChiLan1.0
GDF9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15134,437,497 - 134,442,706 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,437,497 - 134,442,846 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05128,278,496 - 128,284,003 (-)NCBIMhudiblu_PPA_v0panPan3
GDF9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11121,143,982 - 21,148,945 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,143,975 - 21,149,825 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,947,216 - 19,950,085 (-)NCBI
ROS_Cfam_1.01121,931,257 - 21,936,235 (-)NCBI
UMICH_Zoey_3.11120,650,008 - 20,652,875 (-)NCBI
UNSW_CanFamBas_1.01120,497,735 - 20,500,586 (-)NCBI
UU_Cfam_GSD_1.01121,140,232 - 21,143,105 (-)NCBI
Gdf9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,347,586 - 115,353,836 (+)NCBI
SpeTri2.0NW_0049366472,351,604 - 2,357,043 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDF9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2135,180,104 - 135,186,389 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12135,181,494 - 135,184,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,650,007 - 140,652,964 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GDF9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,678,956 - 35,684,378 (-)NCBI
ChlSab1.1 Ensembl2335,679,368 - 35,682,338 (-)Ensembl
Vero_WHO_p1.0NW_02366603442,258,633 - 42,263,520 (+)NCBI
Gdf9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473339,235,128 - 39,240,557 (+)NCBI

Position Markers
ECD03168  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,199,356 - 132,200,159UniSTSGRCh37
Build 365132,227,255 - 132,228,058RGDNCBI36
Celera5128,329,380 - 128,330,183RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,392,073 - 127,392,876UniSTS
ECD03404  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,200,254 - 132,201,050UniSTSGRCh37
Build 365132,228,153 - 132,228,949RGDNCBI36
Celera5128,330,278 - 128,331,074RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,392,971 - 127,393,767UniSTS
ECD03951  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,201,088 - 132,201,867UniSTSGRCh37
Build 365132,228,987 - 132,229,766RGDNCBI36
Celera5128,331,112 - 128,331,891RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,393,805 - 127,394,584UniSTS
ECD05970  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,196,947 - 132,197,668UniSTSGRCh37
Build 365132,224,846 - 132,225,567RGDNCBI36
Celera5128,326,971 - 128,327,692RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,389,663 - 127,390,384UniSTS
ECD06333  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,197,736 - 132,198,447UniSTSGRCh37
Build 365132,225,635 - 132,226,346RGDNCBI36
Celera5128,327,760 - 128,328,471RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,390,452 - 127,391,163UniSTS
ECD21257  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,198,841 - 132,199,096UniSTSGRCh37
Build 365132,226,740 - 132,226,995RGDNCBI36
Celera5128,328,865 - 128,329,120RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,391,557 - 127,391,812UniSTS
REN71988  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,196,416 - 132,196,684UniSTSGRCh37
Build 365132,224,315 - 132,224,583RGDNCBI36
Celera5128,326,440 - 128,326,708RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,389,132 - 127,389,400UniSTS
REN71989  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,196,660 - 132,196,887UniSTSGRCh37
Build 365132,224,559 - 132,224,786RGDNCBI36
Celera5128,326,684 - 128,326,911RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,389,376 - 127,389,603UniSTS
REN71990  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,196,862 - 132,197,105UniSTSGRCh37
Build 365132,224,761 - 132,225,004RGDNCBI36
Celera5128,326,886 - 128,327,129RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,389,578 - 127,389,821UniSTS
REN71991  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,197,094 - 132,197,340UniSTSGRCh37
Build 365132,224,993 - 132,225,239RGDNCBI36
Celera5128,327,118 - 128,327,364RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,389,810 - 127,390,056UniSTS
REN71992  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,197,322 - 132,197,563UniSTSGRCh37
Build 365132,225,221 - 132,225,462RGDNCBI36
Celera5128,327,346 - 128,327,587RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,390,038 - 127,390,279UniSTS
REN71993  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,197,539 - 132,197,777UniSTSGRCh37
Build 365132,225,438 - 132,225,676RGDNCBI36
Celera5128,327,563 - 128,327,801RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,390,255 - 127,390,493UniSTS
REN71994  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,197,739 - 132,197,976UniSTSGRCh37
Build 365132,225,638 - 132,225,875RGDNCBI36
Celera5128,327,763 - 128,328,000RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,390,455 - 127,390,692UniSTS
REN71995  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,197,954 - 132,198,211UniSTSGRCh37
Build 365132,225,853 - 132,226,110RGDNCBI36
Celera5128,327,978 - 128,328,235RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,390,670 - 127,390,927UniSTS
REN71996  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,198,204 - 132,198,447UniSTSGRCh37
Build 365132,226,103 - 132,226,346RGDNCBI36
Celera5128,328,228 - 128,328,471RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,390,920 - 127,391,163UniSTS
REN71997  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,198,401 - 132,198,639UniSTSGRCh37
Build 365132,226,300 - 132,226,538RGDNCBI36
Celera5128,328,425 - 128,328,663RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,391,117 - 127,391,355UniSTS
REN71998  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,198,611 - 132,198,846UniSTSGRCh37
Build 365132,226,510 - 132,226,745RGDNCBI36
Celera5128,328,635 - 128,328,870RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,391,327 - 127,391,562UniSTS
REN71999  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,198,835 - 132,199,090UniSTSGRCh37
Build 365132,226,734 - 132,226,989RGDNCBI36
Celera5128,328,859 - 128,329,114RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,391,551 - 127,391,806UniSTS
REN72000  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,198,900 - 132,199,124UniSTSGRCh37
Build 365132,226,799 - 132,227,023RGDNCBI36
Celera5128,328,924 - 128,329,148RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,391,616 - 127,391,840UniSTS
REN72001  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,199,355 - 132,199,581UniSTSGRCh37
Build 365132,227,254 - 132,227,480RGDNCBI36
Celera5128,329,379 - 128,329,605RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,392,072 - 127,392,298UniSTS
REN72002  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,199,538 - 132,199,802UniSTSGRCh37
Build 365132,227,437 - 132,227,701RGDNCBI36
Celera5128,329,562 - 128,329,826RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,392,255 - 127,392,519UniSTS
REN72003  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,199,785 - 132,200,037UniSTSGRCh37
Build 365132,227,684 - 132,227,936RGDNCBI36
Celera5128,329,809 - 128,330,061RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,392,502 - 127,392,754UniSTS
REN72004  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,200,004 - 132,200,250UniSTSGRCh37
Build 365132,227,903 - 132,228,149RGDNCBI36
Celera5128,330,028 - 128,330,274RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,392,721 - 127,392,967UniSTS
REN72005  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,200,244 - 132,200,481UniSTSGRCh37
Build 365132,228,143 - 132,228,380RGDNCBI36
Celera5128,330,268 - 128,330,505RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,392,961 - 127,393,198UniSTS
REN72006  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,200,468 - 132,200,699UniSTSGRCh37
Build 365132,228,367 - 132,228,598RGDNCBI36
Celera5128,330,492 - 128,330,723RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,393,185 - 127,393,416UniSTS
REN72007  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,200,675 - 132,200,924UniSTSGRCh37
Build 365132,228,574 - 132,228,823RGDNCBI36
Celera5128,330,699 - 128,330,948RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,393,392 - 127,393,641UniSTS
REN72008  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,200,920 - 132,201,176UniSTSGRCh37
Build 365132,228,819 - 132,229,075RGDNCBI36
Celera5128,330,944 - 128,331,200RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,393,637 - 127,393,893UniSTS
REN72009  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,201,154 - 132,201,414UniSTSGRCh37
Build 365132,229,053 - 132,229,313RGDNCBI36
Celera5128,331,178 - 128,331,438RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,393,871 - 127,394,131UniSTS
REN72010  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,201,399 - 132,201,640UniSTSGRCh37
Build 365132,229,298 - 132,229,539RGDNCBI36
Celera5128,331,423 - 128,331,664RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,394,116 - 127,394,357UniSTS
REN72011  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,201,620 - 132,201,869UniSTSGRCh37
Build 365132,229,519 - 132,229,768RGDNCBI36
Celera5128,331,644 - 128,331,893RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,394,337 - 127,394,586UniSTS
REN72012  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,201,822 - 132,202,074UniSTSGRCh37
Build 365132,229,721 - 132,229,973RGDNCBI36
Celera5128,331,846 - 128,332,098RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,394,539 - 127,394,791UniSTS
REN72013  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,202,052 - 132,202,307UniSTSGRCh37
Build 365132,229,951 - 132,230,206RGDNCBI36
Celera5128,332,076 - 128,332,331RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,394,769 - 127,395,024UniSTS
REN72014  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,202,249 - 132,202,474UniSTSGRCh37
Build 365132,230,148 - 132,230,373RGDNCBI36
Celera5128,332,273 - 128,332,498RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,394,966 - 127,395,191UniSTS
stSG601579  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,196,472 - 132,197,524UniSTSGRCh37
Build 365132,224,371 - 132,225,423RGDNCBI36
Celera5128,326,496 - 128,327,548RGD
HuRef5127,389,188 - 127,390,240UniSTS
stSG601580  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,197,505 - 132,198,863UniSTSGRCh37
Build 365132,225,404 - 132,226,762RGDNCBI36
Celera5128,327,529 - 128,328,887RGD
HuRef5127,390,221 - 127,391,579UniSTS
stSG601581  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,198,841 - 132,200,336UniSTSGRCh37
Build 365132,226,740 - 132,228,235RGDNCBI36
Celera5128,328,865 - 128,330,360RGD
HuRef5127,391,557 - 127,393,053UniSTS
stSG601582  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,200,317 - 132,201,814UniSTSGRCh37
Build 365132,228,216 - 132,229,713RGDNCBI36
Celera5128,330,341 - 128,331,838RGD
HuRef5127,393,034 - 127,394,531UniSTS
GDF9_V237  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,197,130 - 132,197,970UniSTSGRCh37
Build 365132,225,029 - 132,225,869RGDNCBI36
Celera5128,327,154 - 128,327,994RGD
HuRef5127,389,846 - 127,390,686UniSTS
WI-21813  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,196,908 - 132,197,166UniSTSGRCh37
Build 365132,224,807 - 132,225,065RGDNCBI36
Celera5128,326,932 - 128,327,190RGD
Cytogenetic Map5q31.1UniSTS
GeneMap99-GB4 RH Map5500.64UniSTS
Whitehead-RH Map5417.1UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:568
Count of miRNA genes:340
Interacting mature miRNAs:367
Transcripts:ENST00000296875, ENST00000378673, ENST00000464378, ENST00000472320
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 351 1
Low 1213 840 1312 269 849 152 3049 774 3295 302 802 1116 123 539 1965 3
Below cutoff 1217 2036 407 349 989 308 1301 1413 415 117 294 485 47 665 821 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_047051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001288828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005271957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006714585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA604716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC004500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX117145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA488820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB040027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB320693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY015857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY042819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY045713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY211060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000296875   ⟹   ENSP00000296875
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5132,861,184 - 132,866,330 (-)Ensembl
RefSeq Acc Id: ENST00000378673   ⟹   ENSP00000367942
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5132,861,181 - 132,866,637 (-)Ensembl
RefSeq Acc Id: ENST00000464378
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5132,862,384 - 132,866,546 (-)Ensembl
RefSeq Acc Id: ENST00000472320
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5132,862,466 - 132,866,884 (-)Ensembl
RefSeq Acc Id: ENST00000621295   ⟹   ENSP00000484339
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5132,861,184 - 132,866,884 (-)Ensembl
RefSeq Acc Id: ENST00000624492   ⟹   ENSP00000485037
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5132,861,184 - 132,866,884 (-)Ensembl
RefSeq Acc Id: ENST00000624495   ⟹   ENSP00000485231
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5132,861,184 - 132,866,579 (-)Ensembl
RefSeq Acc Id: NM_001288824   ⟹   NP_001275753
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,861,185 - 132,866,651 (-)NCBI
HuRef5127,389,589 - 127,395,293 (-)NCBI
CHM1_15131,630,158 - 131,635,861 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001288825   ⟹   NP_001275754
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,861,185 - 132,866,651 (-)NCBI
HuRef5127,389,589 - 127,395,293 (-)NCBI
CHM1_15131,630,158 - 131,635,861 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001288826   ⟹   NP_001275755
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,861,185 - 132,866,579 (-)NCBI
HuRef5127,389,589 - 127,395,293 (-)NCBI
CHM1_15131,630,158 - 131,635,556 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001288827   ⟹   NP_001275756
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,861,185 - 132,866,330 (-)NCBI
HuRef5127,389,589 - 127,395,293 (-)NCBI
CHM1_15131,630,158 - 131,635,307 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001288828   ⟹   NP_001275757
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,861,185 - 132,866,579 (-)NCBI
HuRef5127,389,589 - 127,395,293 (-)NCBI
CHM1_15131,630,158 - 131,635,556 (-)NCBI
Sequence:
RefSeq Acc Id: NM_005260   ⟹   NP_005251
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,861,185 - 132,866,469 (-)NCBI
GRCh375132,196,877 - 132,202,238 (-)NCBI
Build 365132,224,777 - 132,228,376 (-)NCBI Archive
HuRef5127,389,589 - 127,395,293 (-)NCBI
CHM1_15131,630,158 - 131,633,510 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005271957   ⟹   XP_005272014
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,861,181 - 132,865,614 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006714585   ⟹   XP_006714648
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,861,181 - 132,866,079 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011543308   ⟹   XP_011541610
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,861,181 - 132,866,469 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011543309   ⟹   XP_011541611
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,861,181 - 132,866,559 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011543310   ⟹   XP_011541612
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,861,181 - 132,866,578 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011543311   ⟹   XP_011541613
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,861,185 - 132,865,519 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005251   ⟸   NM_005260
- Peptide Label: isoform 1 preproprotein
- UniProtKB: O60383 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005272014   ⟸   XM_005271957
- Peptide Label: isoform X2
- UniProtKB: B4DXG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001275753   ⟸   NM_001288824
- Peptide Label: isoform 2
- UniProtKB: O60383 (UniProtKB/Swiss-Prot),   B4DXG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001275754   ⟸   NM_001288825
- Peptide Label: isoform 2
- UniProtKB: B4DXG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001275757   ⟸   NM_001288828
- Peptide Label: isoform 2
- UniProtKB: B4DXG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001275755   ⟸   NM_001288826
- Peptide Label: isoform 2
- UniProtKB: B4DXG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001275756   ⟸   NM_001288827
- Peptide Label: isoform 2
- UniProtKB: B4DXG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006714648   ⟸   XM_006714585
- Peptide Label: isoform X2
- UniProtKB: B4DXG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011541612   ⟸   XM_011543310
- Peptide Label: isoform X2
- UniProtKB: B4DXG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011541610   ⟸   XM_011543308
- Peptide Label: isoform X1
- UniProtKB: O60383 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011541611   ⟸   XM_011543309
- Peptide Label: isoform X2
- UniProtKB: B4DXG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011541613   ⟸   XM_011543311
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000484339   ⟸   ENST00000621295
RefSeq Acc Id: ENSP00000485037   ⟸   ENST00000624492
RefSeq Acc Id: ENSP00000485231   ⟸   ENST00000624495
RefSeq Acc Id: ENSP00000296875   ⟸   ENST00000296875
RefSeq Acc Id: ENSP00000367942   ⟸   ENST00000378673
Protein Domains
TGF_BETA_2

Promoters
RGD ID:6803216
Promoter ID:HG_KWN:51083
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:NM_005260
Position:
Human AssemblyChrPosition (strand)Source
Build 365132,229,071 - 132,229,571 (-)MPROMDB
RGD ID:6803217
Promoter ID:HG_KWN:51084
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_2Hour,   HeLa_S3,   K562
Transcripts:ENST00000378673,   OTTHUMT00000319628,   OTTHUMT00000319629
Position:
Human AssemblyChrPosition (strand)Source
Build 365132,229,986 - 132,230,486 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_005260.5(GDF9):c.1330G>T (p.Glu444Ter) single nucleotide variant not provided [RCV000729130] Chr5:132861624 [GRCh38]
Chr5:132197316 [GRCh37]
Chr5:5q31.1
uncertain significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q23.2-31.1(chr5:126438406-132873967)x1 copy number loss See cases [RCV000052109] Chr5:126438406..132873967 [GRCh38]
Chr5:125774098..132209659 [GRCh37]
Chr5:125801997..132237558 [NCBI36]
Chr5:5q23.2-31.1
pathogenic
GRCh38/hg38 5q31.1(chr5:132816203-135383158)x1 copy number loss See cases [RCV000052113] Chr5:132816203..135383158 [GRCh38]
Chr5:132151895..134718848 [GRCh37]
Chr5:132179794..134746747 [NCBI36]
Chr5:5q31.1
pathogenic
GRCh38/hg38 5q31.1(chr5:132301874-134187817)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053312]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053312]|See cases [RCV000053312] Chr5:132301874..134187817 [GRCh38]
Chr5:131637567..133523508 [GRCh37]
Chr5:131665466..133551407 [NCBI36]
Chr5:5q31.1
uncertain significance
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
NM_005260.4(GDF9):c.379C>T (p.Pro127Ser) single nucleotide variant Malignant melanoma [RCV000061107] Chr5:132864155 [GRCh38]
Chr5:132199847 [GRCh37]
Chr5:132227746 [NCBI36]
Chr5:5q31.1
not provided
NM_005260.5(GDF9):c.546G>A (p.Glu182=) single nucleotide variant not specified [RCV000125220] Chr5:132862408 [GRCh38]
Chr5:132198100 [GRCh37]
Chr5:5q31.1
benign
GRCh38/hg38 5q31.1(chr5:131626503-135815054)x1 copy number loss See cases [RCV000135442] Chr5:131626503..135815054 [GRCh38]
Chr5:130962196..135150743 [GRCh37]
Chr5:130990095..135178642 [NCBI36]
Chr5:5q31.1
pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NM_005260.5(GDF9):c.-32A>G single nucleotide variant not specified [RCV000426886] Chr5:132864565 [GRCh38]
Chr5:132200257 [GRCh37]
Chr5:5q31.1
benign
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NM_005260.5(GDF9):c.783del (p.Ser262fs) deletion Premature ovarian failure 14 [RCV000656489] Chr5:132862171 [GRCh38]
Chr5:132197863 [GRCh37]
Chr5:5q31.1
pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV001381154]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5q31.1(chr5:131484039-132998360)x3 copy number gain Blepharophimosis [RCV000677199] Chr5:131484039..132998360 [GRCh37]
Chr5:5q31.1
uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q23.2-31.2(chr5:126377719-136270989)x1 copy number loss not provided [RCV000762739] Chr5:126377719..136270989 [GRCh37]
Chr5:5q23.2-31.2
likely pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
NM_001288824.3(GDF9):c.-32+37A>G single nucleotide variant not provided [RCV000836254] Chr5:132866562 [GRCh38]
Chr5:132202254 [GRCh37]
Chr5:5q31.1
likely benign
NM_005260.5(GDF9):c.-616_-142dup duplication Premature ovarian failure [RCV000787459] Chr5:132864674..132864675 [GRCh38]
Chr5:132200366..132200367 [GRCh37]
Chr5:5q31.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4224 AgrOrtholog
COSMIC GDF9 COSMIC
Ensembl Genes ENSG00000164404 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000296875 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000367942 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000484339 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000485037 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000485231 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000296875 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000378673 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000621295 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000624492 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000624495 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000164404 GTEx
HGNC ID HGNC:4224 ENTREZGENE
Human Proteome Map GDF9 Human Proteome Map
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_differentiation_fac-9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2661 UniProtKB/Swiss-Prot
NCBI Gene 2661 ENTREZGENE
OMIM 601918 OMIM
  618014 OMIM
PANTHER PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11848:SF19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28639 PharmGKB
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B4DXG3 ENTREZGENE, UniProtKB/TrEMBL
  GDF9_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q4VAW5 UniProtKB/Swiss-Prot