MIR10B (microRNA 10b) - Rat Genome Database
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Gene: MIR10B (microRNA 10b) Homo sapiens
Analyze
Symbol: MIR10B
Name: microRNA 10b
RGD ID: 1352164
HGNC Page HGNC
Description: Predicted to be involved in cellular response to alcohol; cellular response to inorganic substance; and response to oxygen levels.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-10b; mir-10b; MIRN10B; miRNA10B
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2176,150,303 - 176,150,412 (+)EnsemblGRCh38hg38GRCh38
GRCh382176,150,303 - 176,150,412 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372177,015,031 - 177,015,140 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362176,723,276 - 176,723,385 (+)NCBINCBI36hg18NCBI36
Celera2170,624,210 - 170,624,319 (+)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2168,891,879 - 168,891,988 (+)NCBIHuRef
CHM1_12177,020,900 - 177,021,009 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12624257   PMID:14573789   PMID:16381832   PMID:16549775   PMID:17604727   PMID:17616659   PMID:17898713   PMID:19536818   PMID:19780876   PMID:20075075   PMID:20550523   PMID:20732742  
PMID:20843787   PMID:20889907   PMID:21037258   PMID:21118818   PMID:21212796   PMID:21241449   PMID:21419107   PMID:21471404   PMID:21562367   PMID:21642433   PMID:21652542   PMID:21769427  
PMID:22018284   PMID:22020939   PMID:22057972   PMID:22293682   PMID:22318752   PMID:22322955   PMID:22528944   PMID:22573479   PMID:22580603   PMID:22836757   PMID:22847191   PMID:22915757  
PMID:22955733   PMID:22983574   PMID:23034333   PMID:23125021   PMID:23206733   PMID:23238818   PMID:23307328   PMID:23351547   PMID:23563786   PMID:23670532   PMID:23839045   PMID:23987127  
PMID:24096486   PMID:24100613   PMID:24175854   PMID:24376640   PMID:24412053   PMID:24457988   PMID:24481854   PMID:24573354   PMID:24714979   PMID:24768260   PMID:24793999   PMID:24804980  
PMID:25236186   PMID:25266482   PMID:25426550   PMID:25428807   PMID:25510966   PMID:25596707   PMID:25597482   PMID:25606801   PMID:25612666   PMID:25659925   PMID:25738367   PMID:25773393  
PMID:25869877   PMID:25875782   PMID:25889241   PMID:25896413   PMID:25988292   PMID:26191201   PMID:26206152   PMID:26208390   PMID:26355456   PMID:26394044   PMID:26522916   PMID:26549320  
PMID:26617769   PMID:26646931   PMID:26743475   PMID:26796749   PMID:26909466   PMID:27002147   PMID:27016415   PMID:27113763   PMID:27173192   PMID:27296950   PMID:27380148   PMID:27447302  
PMID:27467502   PMID:27494896   PMID:27592860   PMID:27624142   PMID:27669739   PMID:27756250   PMID:27764757   PMID:27834869   PMID:28039186   PMID:28112253   PMID:28153089   PMID:28345456  
PMID:28360191   PMID:28393237   PMID:28431233   PMID:28601079   PMID:28691018   PMID:28797712   PMID:28864233   PMID:29023075   PMID:29180037   PMID:29254787   PMID:29331391   PMID:29408861  
PMID:29506532   PMID:29672315   PMID:29691981   PMID:29848733   PMID:29956786   PMID:30166612   PMID:30215459   PMID:30403658   PMID:30423386   PMID:30468483   PMID:30504727   PMID:30514328  
PMID:30551353   PMID:30552989   PMID:30658617   PMID:30720165   PMID:30975094   PMID:30995246   PMID:31032663   PMID:31037150   PMID:31095782   PMID:31129246   PMID:31289362   PMID:31594209  
PMID:31740975   PMID:31772141   PMID:31926946   PMID:31948751   PMID:32223957  


Genomics

Comparative Map Data
MIR10B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2176,150,303 - 176,150,412 (+)EnsemblGRCh38hg38GRCh38
GRCh382176,150,303 - 176,150,412 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372177,015,031 - 177,015,140 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362176,723,276 - 176,723,385 (+)NCBINCBI36hg18NCBI36
Celera2170,624,210 - 170,624,319 (+)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2168,891,879 - 168,891,988 (+)NCBIHuRef
CHM1_12177,020,900 - 177,021,009 (+)NCBICHM1_1
Mir10b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39274,556,414 - 74,556,481 (+)NCBIGRCm39mm39
GRCm38274,726,070 - 74,726,137 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl274,726,070 - 74,726,137 (+)EnsemblGRCm38mm10GRCm38
MGSCv37274,564,127 - 74,564,194 (+)NCBIGRCm37mm9NCBIm37
Celera276,396,199 - 76,396,266 (+)NCBICelera
Cytogenetic Map2C3NCBI
Mir10b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0361,647,978 - 61,648,086 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl361,647,978 - 61,648,086 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0368,113,662 - 68,113,770 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera359,149,937 - 59,150,045 (+)NCBICelera
Cytogenetic Map3q23NCBI
MIR10B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3619,958,913 - 19,959,013 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13619,958,913 - 19,959,013 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
MIR10B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1581,951,636 - 81,951,736 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11581,951,644 - 81,951,723 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21591,419,021 - 91,419,100 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
CDKN1Ahsa-miR-10b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21471404
CDKN2Ahsa-miR-10b-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
PIEZO1hsa-miR-10b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22322955
HOXD10hsa-miR-10b-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assayFunctional MTI17898713
HOXD10hsa-miR-10b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21419107
HOXD10hsa-miR-10b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23034333
HOXD10hsa-miR-10b-5pMirtarbaseexternal_infoReporter assayFunctional MTI21642433
TRA2Bhsa-miR-10b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21118818
KLF4hsa-miR-10b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20075075
PPARAhsa-miR-10b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19780876
NCOR2hsa-miR-10b-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI21212796
NF1hsa-miR-10b-5pMirtarbaseexternal_infoGFP reporter assay//Luciferase reporter assay//MicFunctional MTI20550523
MAPRE1hsa-miR-10b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21562367
SDC1hsa-miR-10b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22573479
NR4A3hsa-miR-10b-5pMirtarbaseexternal_infoReporter assayNon-Functional MTI21642433
HOXD10hsa-miR-10b-5pTarbaseexternal_infoReporter GenePOSITIVE
NR4A3hsa-miR-10b-5pTarbaseexternal_infoReporter GeneNEGATIVE
CDH1hsa-miR-10b-5pOncomiRDBexternal_infoNANA22847191
SDC1hsa-miR-10b-5pOncomiRDBexternal_infoNANA22573479
CSMD1hsa-miR-10b-5pOncomiRDBexternal_infoNANA22558405
CADM1hsa-miR-10b-5pOncomiRDBexternal_infoNANA22528944
BCL2L11hsa-miR-10b-5pOncomiRDBexternal_infoNANA22322955
HOXD10hsa-miR-10b-5pOncomiRDBexternal_infoNANA22293682
MAPRE1hsa-miR-10b-5pOncomiRDBexternal_infoNANA21562367
BCL2L11hsa-miR-10b-5pOncomiRDBexternal_infoNANA21471404
HOXD10hsa-miR-10b-5pOncomiRDBexternal_infoNANA21419107
NCOR2hsa-miR-10b-5pOncomiRDBexternal_infoNANA21212796
SRSF1hsa-miR-10b-5pOncomiRDBexternal_infoNANA21118818
NF1hsa-miR-10b-5pOncomiRDBexternal_infoNANA20550523
TIAM1hsa-miR-10b-5pOncomiRDBexternal_infoNANA20444703
KLF4hsa-miR-10b-5pOncomiRDBexternal_infoNANA20075075
HOXD10hsa-miR-10b-5pOncomiRDBexternal_infoNANA17898713
AMMECR1hsa-miR-10b-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
HOXD10hsa-miR-10b-3pMirecordsexternal_infoNANA17898713
KLF4hsa-miR-10b-3pMirecordsexternal_info{unchanged}NA20075075
BUB1hsa-miR-10b-3pOncomiRDBexternal_infoNANA23125021

Predicted Targets
Summary Value
Count of predictions:34724
Count of gene targets:14463
Count of transcripts:29064
Interacting mature miRNAs:hsa-miR-10b-3p, hsa-miR-10b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 6 3 2 2 2 8 18 25 10 13 24
Low 62 4 15 5 21 7 83 36 58 61 118 101 2 11 8
Below cutoff 55 19 17 5 11 2 59 17 19 20 54 27 3 50 20

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385011
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2176,150,303 - 176,150,412 (+)Ensembl
RefSeq Acc Id: NR_029609
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382176,150,303 - 176,150,412 (+)NCBI
GRCh372177,015,031 - 177,015,140 (+)ENTREZGENE
HuRef2168,891,879 - 168,891,988 (+)ENTREZGENE
CHM1_12177,020,900 - 177,021,009 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q31.1-33.2(chr2:174898848-203941548)x1 copy number loss See cases [RCV000050980] Chr2:174898848..203941548 [GRCh38]
Chr2:175763576..204806271 [GRCh37]
Chr2:175471822..204514516 [NCBI36]
Chr2:2q31.1-33.2
pathogenic
GRCh38/hg38 2q31.1-31.2(chr2:172779876-177598000)x1 copy number loss See cases [RCV000050765] Chr2:172779876..177598000 [GRCh38]
Chr2:173644604..178462728 [GRCh37]
Chr2:173352850..178170974 [NCBI36]
Chr2:2q31.1-31.2
pathogenic
GRCh38/hg38 2q31.1(chr2:172366752-176361187)x1 copy number loss See cases [RCV000052554] Chr2:172366752..176361187 [GRCh38]
Chr2:173231480..177225915 [GRCh37]
Chr2:172939726..176934161 [NCBI36]
Chr2:2q31.1
pathogenic
GRCh38/hg38 2q31.1-31.2(chr2:173408061-177702487)x1 copy number loss See cases [RCV000052555] Chr2:173408061..177702487 [GRCh38]
Chr2:174272789..178567215 [GRCh37]
Chr2:173981035..178275461 [NCBI36]
Chr2:2q31.1-31.2
pathogenic
GRCh38/hg38 2q24.3-32.1(chr2:163965382-182195062)x1 copy number loss See cases [RCV000054122] Chr2:163965382..182195062 [GRCh38]
Chr2:164821892..183059789 [GRCh37]
Chr2:164530138..182768034 [NCBI36]
Chr2:2q24.3-32.1
pathogenic
GRCh38/hg38 2q31.1-32.1(chr2:170407688-186189894)x1 copy number loss See cases [RCV000054127] Chr2:170407688..186189894 [GRCh38]
Chr2:171264198..187054621 [GRCh37]
Chr2:170972444..186762866 [NCBI36]
Chr2:2q31.1-32.1
pathogenic
GRCh38/hg38 2q31.1-32.2(chr2:171429233-189179568)x1 copy number loss See cases [RCV000136850] Chr2:171429233..189179568 [GRCh38]
Chr2:172285743..190044294 [GRCh37]
Chr2:171993989..189752539 [NCBI36]
Chr2:2q31.1-32.2
pathogenic
GRCh38/hg38 2q31.1-32.2(chr2:174634502-189000964)x1 copy number loss See cases [RCV000136861] Chr2:174634502..189000964 [GRCh38]
Chr2:175499230..189865690 [GRCh37]
Chr2:175207476..189573935 [NCBI36]
Chr2:2q31.1-32.2
pathogenic
GRCh38/hg38 2q31.1(chr2:176075289-176156257)x1 copy number loss See cases [RCV000137847] Chr2:176075289..176156257 [GRCh38]
Chr2:176940017..177020985 [GRCh37]
Chr2:176648263..176729231 [NCBI36]
Chr2:2q31.1
pathogenic
GRCh38/hg38 2q31.1-31.2(chr2:171513047-177854080)x1 copy number loss See cases [RCV000139646] Chr2:171513047..177854080 [GRCh38]
Chr2:172369557..178718807 [GRCh37]
Chr2:172077803..178427053 [NCBI36]
Chr2:2q31.1-31.2
pathogenic
GRCh38/hg38 2q31.1-31.3(chr2:174236451-181188846)x1 copy number loss See cases [RCV000143597] Chr2:174236451..181188846 [GRCh38]
Chr2:175101179..182053573 [GRCh37]
Chr2:174809425..181761818 [NCBI36]
Chr2:2q31.1-31.3
pathogenic
GRCh38/hg38 2q31.1-32.3(chr2:176086763-193201970)x1 copy number loss See cases [RCV000143484] Chr2:176086763..193201970 [GRCh38]
Chr2:176951491..194066696 [GRCh37]
Chr2:176659737..193774941 [NCBI36]
Chr2:2q31.1-32.3
pathogenic
GRCh37/hg19 2q24.1-31.3(chr2:156489430-182921298)x3 copy number gain See cases [RCV000239848] Chr2:156489430..182921298 [GRCh37]
Chr2:2q24.1-31.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q31.1-35(chr2:169829974-215521436)x3 copy number gain See cases [RCV000448271] Chr2:169829974..215521436 [GRCh37]
Chr2:2q31.1-35
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q31.1-31.2(chr2:173741558-178416381)x1 copy number loss not provided [RCV000682153] Chr2:173741558..178416381 [GRCh37]
Chr2:2q31.1-31.2
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q23.3-31.2(chr2:152409978-179325736)x3 copy number gain not provided [RCV000740654] Chr2:152409978..179325736 [GRCh37]
Chr2:2q23.3-31.2
pathogenic
GRCh37/hg19 2q31.1-31.3(chr2:174238257-181604341)x1 copy number loss not provided [RCV000740710] Chr2:174238257..181604341 [GRCh37]
Chr2:2q31.1-31.3
pathogenic
GRCh37/hg19 2q31.1(chr2:176950926-177047801)x3 copy number gain not provided [RCV000740716] Chr2:176950926..177047801 [GRCh37]
Chr2:2q31.1
benign
GRCh37/hg19 2q31.1(chr2:176951487-177070756)x3 copy number gain not provided [RCV000740717] Chr2:176951487..177070756 [GRCh37]
Chr2:2q31.1
benign
GRCh37/hg19 2q31.1-31.2(chr2:176794846-178494259) copy number loss not provided [RCV000767781] Chr2:176794846..178494259 [GRCh37]
Chr2:2q31.1-31.2
pathogenic
GRCh37/hg19 2q31.1-31.2(chr2:176310551-179092634)x1 copy number loss not provided [RCV000849015] Chr2:176310551..179092634 [GRCh37]
Chr2:2q31.1-31.2
pathogenic
GRCh37/hg19 2q31.1-32.1(chr2:173538954-186401606)x1 copy number loss not provided [RCV000846537] Chr2:173538954..186401606 [GRCh37]
Chr2:2q31.1-32.1
pathogenic
GRCh37/hg19 2q24.3-32.3(chr2:167329586-192756373)x1 copy number loss not provided [RCV000848216] Chr2:167329586..192756373 [GRCh37]
Chr2:2q24.3-32.3
pathogenic
GRCh37/hg19 2q24.2-34(chr2:163233162-211927188)x3 copy number gain not provided [RCV001005349] Chr2:163233162..211927188 [GRCh37]
Chr2:2q24.2-34
pathogenic
GRCh37/hg19 2q31.1-32.3(chr2:174690039-195521582)x1 copy number loss not provided [RCV001005359] Chr2:174690039..195521582 [GRCh37]
Chr2:2q31.1-32.3
pathogenic
GRCh37/hg19 2q24.2-31.3(chr2:163078055-182119617)x1 copy number loss 2q24 microdeletion syndrome [RCV001263223] Chr2:163078055..182119617 [GRCh37]
Chr2:2q24.2-31.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31498 AgrOrtholog
COSMIC MIR10B COSMIC
Ensembl Genes ENSG00000207744 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385011 ENTREZGENE
GTEx ENSG00000207744 GTEx
HGNC ID HGNC:31498 ENTREZGENE
Human Proteome Map MIR10B Human Proteome Map
miRBase MI0000267 ENTREZGENE
NCBI Gene 406903 ENTREZGENE
OMIM 611576 OMIM
PharmGKB PA164722346 PharmGKB
RNAcentral URS00004AC389 RNACentral
  URS00004CAC40 RNACentral
  URS000058760A RNACentral