NTF3 (neurotrophin 3) - Rat Genome Database

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Gene: NTF3 (neurotrophin 3) Homo sapiens
Analyze
Symbol: NTF3
Name: neurotrophin 3
RGD ID: 732368
HGNC Page HGNC
Description: Exhibits chemoattractant activity and growth factor activity. Involved in several processes, including activation of GTPase activity; positive regulation of cellular component organization; and regulation of protein phosphorylation. Predicted to localize to several cellular components, including axon; dendrite; and synaptic vesicle. Implicated in Alzheimer's disease and asthma. Biomarker of chronic obstructive pulmonary disease; hydrocephalus; and pulmonary sarcoidosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HDNF; MGC129711; nerve growth factor 2; neurotrophic factor; neurotrophin-3; NGF-2; NGF2; NT-3; NT3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl125,432,108 - 5,521,536 (+)EnsemblGRCh38hg38GRCh38
GRCh38125,432,108 - 5,495,299 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37125,541,274 - 5,604,465 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36125,411,541 - 5,474,726 (+)NCBINCBI36hg18NCBI36
Build 34125,473,526 - 5,474,725NCBI
Celera127,162,184 - 7,225,194 (+)NCBI
Cytogenetic Map12p13.31NCBI
HuRef125,455,606 - 5,458,036 (+)NCBIHuRef
CHM1_1125,540,527 - 5,604,287 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,7-dihydropurine-6-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-aminonicotinamide  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aflatoxin B2  (EXP)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
androgen antagonist  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
cadmium dichloride  (EXP)
Calcimycin  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cimetidine  (ISO)
cisplatin  (EXP)
colforsin daropate hydrochloride  (ISO)
cyclophosphamide  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (ISO)
diethyl maleate  (ISO)
Dimaprit  (ISO)
dopamine  (ISO)
endosulfan  (ISO)
famotidine  (ISO)
formaldehyde  (ISO)
furan  (ISO)
glycidol  (ISO)
histamine  (ISO)
hydrogen peroxide  (EXP)
imetit  (ISO)
indole-3-methanol  (ISO)
isoprenaline  (ISO)
ketamine  (ISO)
lead diacetate  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
LY294002  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
menadione  (EXP)
mepyramine  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (ISO)
methapyrilene  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (ISO)
paracetamol  (EXP)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
purine-6-thiol  (ISO)
scopolamine  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
Soman  (ISO)
staurosporine  (ISO)
streptozocin  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (ISO)
Thioperamide  (ISO)
toluene  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
trimethyltin  (ISO)
triprolidine  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
wortmannin  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (IDA)
activation of protein kinase B activity  (IDA)
axon guidance  (ISO)
brain development  (ISO)
cell-cell signaling  (TAS)
enteric nervous system development  (ISO)
epidermis development  (ISO)
generation of neurons  (ISO)
glial cell fate determination  (ISO)
induction of positive chemotaxis  (IDA)
mechanoreceptor differentiation  (ISO)
memory  (IBA)
modulation of chemical synaptic transmission  (IBA,ISO)
myelination  (ISO)
negative regulation of neuron apoptotic process  (IBA,ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (IDA)
nerve development  (IBA,ISO)
nerve growth factor signaling pathway  (IBA)
nervous system development  (ISO,TAS)
neuromuscular synaptic transmission  (ISO)
neuron development  (ISO)
neuron projection morphogenesis  (IBA)
peripheral nervous system development  (IBA,ISO)
positive chemotaxis  (IEA)
positive regulation of actin cytoskeleton reorganization  (IDA)
positive regulation of cell migration  (IDA)
positive regulation of cell population proliferation  (IDA)
positive regulation of glial cell differentiation  (ISO)
positive regulation of MAP kinase activity  (IDA)
positive regulation of peptidyl-serine phosphorylation  (IBA,IDA)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of receptor internalization  (IDA)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of apoptotic process  (IGI)
regulation of neuron apoptotic process  (ISO)
regulation of neuron differentiation  (IBA)
signal transduction  (TAS)
smooth muscle cell differentiation  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA,IDA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:1542658   PMID:1645620   PMID:1889807   PMID:2025430   PMID:2236018   PMID:2344409   PMID:2365067   PMID:7514502   PMID:7537086   PMID:7703225   PMID:7733919   PMID:7991545  
PMID:8621424   PMID:8819011   PMID:8841198   PMID:8925252   PMID:9488719   PMID:9756741   PMID:9973222   PMID:11877300   PMID:11920853   PMID:12107412   PMID:12397373   PMID:12477932  
PMID:12598727   PMID:12710933   PMID:12900521   PMID:15146197   PMID:15365216   PMID:15474906   PMID:15489334   PMID:15544837   PMID:15589528   PMID:15770067   PMID:16441896   PMID:16786155  
PMID:17112518   PMID:17192954   PMID:17207965   PMID:17234344   PMID:17698064   PMID:18069415   PMID:18179783   PMID:18203754   PMID:18305571   PMID:18313696   PMID:18336001   PMID:18428117  
PMID:18438927   PMID:18438945   PMID:18596692   PMID:19086053   PMID:19357934   PMID:19369542   PMID:19453261   PMID:19598235   PMID:19680743   PMID:20060128   PMID:20160348   PMID:20219210  
PMID:20360537   PMID:20379614   PMID:20576502   PMID:20597688   PMID:21085492   PMID:21261755   PMID:21392742   PMID:21698095   PMID:21720807   PMID:21787840   PMID:21873635   PMID:21996274  
PMID:22036954   PMID:22158057   PMID:22192858   PMID:22454143   PMID:22459634   PMID:23001042   PMID:23027130   PMID:23038618   PMID:23075484   PMID:23149719   PMID:23185507   PMID:23426664  
PMID:23471121   PMID:23522042   PMID:23869086   PMID:23954828   PMID:24288162   PMID:25275256   PMID:25416956   PMID:25925835   PMID:26186194   PMID:26548545   PMID:26814132   PMID:27214525  
PMID:27367919   PMID:27561780   PMID:28356268   PMID:28370021   PMID:28402394   PMID:28514442   PMID:28611215   PMID:29102768   PMID:29549646   PMID:30098383   PMID:30268839   PMID:31900314  


Genomics

Comparative Map Data
NTF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl125,432,108 - 5,521,536 (+)EnsemblGRCh38hg38GRCh38
GRCh38125,432,108 - 5,495,299 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37125,541,274 - 5,604,465 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36125,411,541 - 5,474,726 (+)NCBINCBI36hg18NCBI36
Build 34125,473,526 - 5,474,725NCBI
Celera127,162,184 - 7,225,194 (+)NCBI
Cytogenetic Map12p13.31NCBI
HuRef125,455,606 - 5,458,036 (+)NCBIHuRef
CHM1_1125,540,527 - 5,604,287 (+)NCBICHM1_1
Ntf3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396126,078,375 - 126,143,734 (-)NCBIGRCm39mm39
GRCm39 Ensembl6126,078,375 - 126,143,873 (-)Ensembl
GRCm386126,101,412 - 126,166,772 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6126,101,412 - 126,166,910 (-)EnsemblGRCm38mm10GRCm38
MGSCv376126,051,430 - 126,116,762 (-)NCBIGRCm37mm9NCBIm37
MGSCv366126,067,031 - 126,130,540 (-)NCBImm8
Celera6127,765,447 - 127,832,752 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map660.45NCBI
Ntf3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24158,914,984 - 158,984,453 (-)NCBI
Rnor_6.0 Ensembl4158,636,884 - 158,705,886 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04158,636,883 - 158,705,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04225,638,801 - 225,707,719 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44162,435,781 - 162,506,961 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14162,680,717 - 162,751,897 (-)NCBI
Celera4147,640,921 - 147,710,546 (-)NCBICelera
Cytogenetic Map4q42NCBI
Ntf3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554133,207,123 - 3,273,491 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554133,207,669 - 3,273,371 (+)NCBIChiLan1.0ChiLan1.0
NTF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1125,470,093 - 5,534,300 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl125,530,508 - 5,533,989 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0125,551,734 - 5,615,981 (+)NCBIMhudiblu_PPA_v0panPan3
NTF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12739,383,017 - 39,454,613 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2739,383,152 - 39,454,601 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,231,693 - 7,233,370 (+)NCBI
ROS_Cfam_1.02739,739,752 - 39,811,227 (-)NCBI
UMICH_Zoey_3.12739,608,720 - 39,679,940 (-)NCBI
UNSW_CanFamBas_1.02739,650,338 - 39,721,747 (-)NCBI
UU_Cfam_GSD_1.0276,639,885 - 6,711,187 (+)NCBI
Ntf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945103,495,858 - 103,555,782 (-)NCBI
SpeTri2.0NW_0049367092,163,510 - 2,223,429 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl565,052,517 - 65,123,788 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1565,052,608 - 65,122,645 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2567,204,186 - 67,204,959 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NTF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,477,208 - 5,542,404 (+)NCBI
Vero_WHO_p1.0NW_0236660632,690,949 - 2,765,784 (-)NCBI
Ntf3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248602,416,448 - 2,479,216 (+)NCBI

Position Markers
D12S99  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37125,564,600 - 5,564,819UniSTSGRCh37
GRCh378139,570,228 - 139,571,337UniSTSGRCh37
GRCh37125,564,771 - 5,564,899UniSTSGRCh37
Build 36125,435,032 - 5,435,160RGDNCBI36
Celera127,185,663 - 7,185,791RGD
Celera8135,739,169 - 135,740,278UniSTS
Celera127,185,492 - 7,185,711UniSTS
Cytogenetic Map12p13UniSTS
HuRef125,420,614 - 5,420,825UniSTS
HuRef125,420,777 - 5,420,905UniSTS
Marshfield Genetic Map1212.6RGD
Genethon Genetic Map1213.9UniSTS
deCODE Assembly Map1215.2UniSTS
Stanford-G3 RH Map12282.0UniSTS
GeneMap99-GB4 RH Map1231.56UniSTS
Whitehead-YAC Contig Map12 UniSTS
NCBI RH Map1281.6UniSTS
GeneMap99-G3 RH Map12282.0UniSTS
G42645  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37125,577,944 - 5,578,377UniSTSGRCh37
Build 36125,448,205 - 5,448,638RGDNCBI36
Celera127,198,834 - 7,199,267RGD
Cytogenetic Map12p13UniSTS
HuRef125,433,944 - 5,434,377UniSTS
GDB:210011  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37125,541,654 - 5,541,804UniSTSGRCh37
Build 36125,411,915 - 5,412,065RGDNCBI36
Celera127,162,558 - 7,162,708RGD
Cytogenetic Map12p13UniSTS
HuRef125,397,680 - 5,397,824UniSTS
GDB:214846  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37125,603,299 - 5,603,818UniSTSGRCh37
Build 36125,473,560 - 5,474,079RGDNCBI36
Celera127,224,028 - 7,224,547RGD
Cytogenetic Map12p13UniSTS
HuRef125,456,870 - 5,457,389UniSTS
SHGC-142535  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37125,596,504 - 5,596,775UniSTSGRCh37
Build 36125,466,765 - 5,467,036RGDNCBI36
Celera127,217,233 - 7,217,504RGD
Cytogenetic Map12p13UniSTS
HuRef125,450,076 - 5,450,347UniSTS
TNG Radiation Hybrid Map123340.0UniSTS
SHGC-943  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37125,564,640 - 5,564,899UniSTSGRCh37
Build 36125,434,901 - 5,435,160RGDNCBI36
Celera127,185,532 - 7,185,791RGD
Cytogenetic Map12p13UniSTS
HuRef125,420,654 - 5,420,905UniSTS
TNG Radiation Hybrid Map123337.0UniSTS
SHGC-149817  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37125,598,360 - 5,598,642UniSTSGRCh37
Build 36125,468,621 - 5,468,903RGDNCBI36
Celera127,219,089 - 7,219,371RGD
Cytogenetic Map12p13UniSTS
HuRef125,451,932 - 5,452,214UniSTS
TNG Radiation Hybrid Map123343.0UniSTS
UniSTS:225313  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37125,604,329 - 5,604,480UniSTSGRCh37
Build 36125,474,590 - 5,474,741RGDNCBI36
Celera127,225,058 - 7,225,209RGD
HuRef125,457,900 - 5,458,051UniSTS
G19257  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37125,570,613 - 5,570,765UniSTSGRCh37
Build 36125,440,874 - 5,441,026RGDNCBI36
Celera127,191,505 - 7,191,657RGD
Cytogenetic Map12p13UniSTS
HuRef125,426,619 - 5,426,771UniSTS
RH48860  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37125,558,635 - 5,558,759UniSTSGRCh37
Build 36125,428,896 - 5,429,020RGDNCBI36
Celera127,179,529 - 7,179,653RGD
Cytogenetic Map12p13UniSTS
HuRef125,414,651 - 5,414,775UniSTS
GeneMap99-GB4 RH Map1231.56UniSTS
NCBI RH Map1281.6UniSTS
Ntf3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37125,603,412 - 5,604,432UniSTSGRCh37
Celera127,224,141 - 7,225,161UniSTS
HuRef125,456,983 - 5,458,003UniSTS
UniSTS:483844  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37125,603,314 - 5,604,344UniSTSGRCh37
Celera127,224,043 - 7,225,073UniSTS
HuRef125,456,885 - 5,457,915UniSTS
D12S99  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p13UniSTS
Marshfield Genetic Map1212.6UniSTS
Genethon Genetic Map1213.9UniSTS
deCODE Assembly Map1215.2UniSTS
GeneMap99-GB4 RH Map1231.56UniSTS
Whitehead-YAC Contig Map12 UniSTS
NCBI RH Map1281.6UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR200Chsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23185507

Predicted Target Of
Summary Value
Count of predictions:1209
Count of miRNA genes:685
Interacting mature miRNAs:806
Transcripts:ENST00000331010, ENST00000423158, ENST00000535299, ENST00000541234, ENST00000543548, ENST00000544836
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 13 1200 5 1 13 1 701 7 32 6 138 26 43 654 1
Low 1693 704 1174 529 485 371 3090 992 1431 279 1191 1156 165 1 1057 1710 2 2
Below cutoff 658 628 503 69 424 67 517 1166 1874 102 80 308 8 104 423 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_050629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001102654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011520963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC007848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC137627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW190653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU939830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD672441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN267386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HD113715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M37763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M61180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000331010   ⟹   ENSP00000328738
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl125,494,132 - 5,495,159 (+)Ensembl
RefSeq Acc Id: ENST00000423158   ⟹   ENSP00000397297
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl125,432,108 - 5,495,299 (+)Ensembl
RefSeq Acc Id: ENST00000535299
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl125,432,112 - 5,521,536 (+)Ensembl
RefSeq Acc Id: ENST00000541234
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl125,511,657 - 5,513,393 (+)Ensembl
RefSeq Acc Id: ENST00000543548
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl125,433,125 - 5,494,501 (+)Ensembl
RefSeq Acc Id: ENST00000544836
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl125,511,609 - 5,513,076 (+)Ensembl
RefSeq Acc Id: NM_001102654   ⟹   NP_001096124
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38125,432,108 - 5,495,299 (+)NCBI
GRCh37125,541,280 - 5,604,465 (+)NCBI
Build 36125,411,541 - 5,474,726 (+)NCBI Archive
HuRef125,455,606 - 5,458,036 (+)ENTREZGENE
CHM1_1125,540,527 - 5,604,287 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002527   ⟹   NP_002518
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38125,494,132 - 5,495,299 (+)NCBI
GRCh37125,541,280 - 5,604,465 (+)ENTREZGENE
Build 36125,473,559 - 5,474,726 (+)NCBI Archive
HuRef125,455,606 - 5,458,036 (+)ENTREZGENE
CHM1_1125,603,120 - 5,604,287 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011520963   ⟹   XP_011519265
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38125,433,060 - 5,495,299 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001096124   ⟸   NM_001102654
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P20783 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_002518   ⟸   NM_002527
- Peptide Label: isoform 2 preproprotein
- UniProtKB: P20783 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011519265   ⟸   XM_011520963
- Peptide Label: isoform X1
- UniProtKB: P20783 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000397297   ⟸   ENST00000423158
RefSeq Acc Id: ENSP00000328738   ⟸   ENST00000331010

Promoters
RGD ID:7222825
Promoter ID:EPDNEW_H17158
Type:initiation region
Name:NTF3_2
Description:neurotrophin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17160  EPDNEW_H17159  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38125,430,332 - 5,430,392EPDNEW
RGD ID:7222833
Promoter ID:EPDNEW_H17159
Type:multiple initiation site
Name:NTF3_3
Description:neurotrophin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17158  EPDNEW_H17160  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38125,431,199 - 5,431,259EPDNEW
RGD ID:7222827
Promoter ID:EPDNEW_H17160
Type:initiation region
Name:NTF3_1
Description:neurotrophin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17158  EPDNEW_H17159  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38125,432,112 - 5,432,172EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.32-13.31(chr12:4832052-5947324)x3 copy number gain See cases [RCV000051954] Chr12:4832052..5947324 [GRCh38]
Chr12:4941218..6056490 [GRCh37]
Chr12:4811479..5926751 [NCBI36]
Chr12:12p13.32-13.31
uncertain significance
GRCh38/hg38 12p13.33-11.22(chr12:121055-28415184)x1 copy number loss See cases [RCV000052776] Chr12:121055..28415184 [GRCh38]
Chr12:282465..28568117 [GRCh37]
Chr12:100482..28459384 [NCBI36]
Chr12:12p13.33-11.22
pathogenic
GRCh38/hg38 12p13.33-12.1(chr12:80412-25470329)x3 copy number gain See cases [RCV000053662] Chr12:80412..25470329 [GRCh38]
Chr12:282465..25623263 [GRCh37]
Chr12:59839..25514530 [NCBI36]
Chr12:12p13.33-12.1
pathogenic
GRCh38/hg38 12p13.33-13.31(chr12:121055-7272606)x3 copy number gain See cases [RCV000053663] Chr12:121055..7272606 [GRCh38]
Chr12:282465..7425202 [GRCh37]
Chr12:100482..7316469 [NCBI36]
Chr12:12p13.33-13.31
pathogenic
GRCh38/hg38 12p13.33-13.31(chr12:121255-8361746)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053664]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053664]|See cases [RCV000053664] Chr12:121255..8361746 [GRCh38]
Chr12:282465..8514342 [GRCh37]
Chr12:100682..8405609 [NCBI36]
Chr12:12p13.33-13.31
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:212976-33926913)x4 copy number gain See cases [RCV000053666] Chr12:212976..33926913 [GRCh38]
Chr12:322142..34079848 [GRCh37]
Chr12:192403..33971115 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:77187-34380176)x3 copy number gain See cases [RCV000053660] Chr12:77187..34380176 [GRCh38]
Chr12:282465..34533111 [GRCh37]
Chr12:56614..34424378 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-13.31(chr12:45740-6945196)x3 copy number gain See cases [RCV000135350] Chr12:45740..6945196 [GRCh38]
Chr12:147099..7054359 [GRCh37]
Chr12:17360..6924620 [NCBI36]
Chr12:12p13.33-13.31
pathogenic
GRCh38/hg38 12p13.33-13.31(chr12:199896-5807366)x1 copy number loss See cases [RCV000136848] Chr12:199896..5807366 [GRCh38]
Chr12:309062..5916532 [GRCh37]
Chr12:179323..5786793 [NCBI36]
Chr12:12p13.33-13.31
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121255-34603274)x3 copy number gain See cases [RCV000136611] Chr12:121255..34603274 [GRCh38]
Chr12:282465..34756209 [GRCh37]
Chr12:100682..34647476 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-12.3(chr12:2871741-14987348)x3 copy number gain See cases [RCV000137694] Chr12:2871741..14987348 [GRCh38]
Chr12:2980907..15140282 [GRCh37]
Chr12:2851168..15031549 [NCBI36]
Chr12:12p13.33-12.3
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121271-34603261)x3 copy number gain See cases [RCV000139052] Chr12:121271..34603261 [GRCh38]
Chr12:282465..34756196 [GRCh37]
Chr12:100698..34647463 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:54427-34608071)x4 copy number gain See cases [RCV000139787] Chr12:54427..34608071 [GRCh38]
Chr12:282465..34761006 [GRCh37]
Chr12:33854..34652273 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.31(chr12:5468308-5516206)x3 copy number gain See cases [RCV000141169] Chr12:5468308..5516206 [GRCh38]
Chr12:5577474..5625372 [GRCh37]
Chr12:5447735..5495633 [NCBI36]
Chr12:12p13.31
uncertain significance
GRCh38/hg38 12p13.33-12.2(chr12:1258274-20657577)x3 copy number gain See cases [RCV000141905] Chr12:1258274..20657577 [GRCh38]
Chr12:1367440..20810511 [GRCh37]
Chr12:1237701..20701778 [NCBI36]
Chr12:12p13.33-12.2
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:64620-34682902)x4 copy number gain See cases [RCV000142149] Chr12:64620..34682902 [GRCh38]
Chr12:173786..34835837 [GRCh37]
Chr12:44047..34727104 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-13.31(chr12:418421-6235914)x3 copy number gain See cases [RCV000143357] Chr12:418421..6235914 [GRCh38]
Chr12:527587..6345080 [GRCh37]
Chr12:397848..6215341 [NCBI36]
Chr12:12p13.33-13.31
pathogenic
NM_001102654.2(NTF3):c.265G>A (p.Gly89Arg) single nucleotide variant Hirschsprung disease 1 [RCV000201299] Chr12:5494440 [GRCh38]
Chr12:5603606 [GRCh37]
Chr12:12p13.31
uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:148034-34178799)x4 copy number gain See cases [RCV000240164] Chr12:148034..34178799 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh38/hg38 12p13.32-13.31(chr12:4772521-5854093)x1 copy number loss Ductal breast carcinoma [RCV000207062] Chr12:4772521..5854093 [GRCh38]
Chr12:4881687..5963259 [GRCh37]
Chr12:12p13.32-13.31
uncertain significance
chr12:4920767-5603935 complex variant complex Ductal breast carcinoma [RCV000207328] Chr12:4920767..5603935 [GRCh37]
Chr12:12p13.32-13.31
uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:89061-34178799)x3 copy number gain See cases [RCV000240487] Chr12:89061..34178799 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301)x3 copy number gain See cases [RCV000449191] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11
pathogenic
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865)x3 copy number gain See cases [RCV000449287] Chr12:173786..25286865 [GRCh37]
Chr12:12p13.33-12.1
pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:173786-6378954)x1 copy number loss See cases [RCV000447106] Chr12:173786..6378954 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain See cases [RCV000447551] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.31(chr12:5578947-5603350)x3 copy number gain See cases [RCV000446912] Chr12:5578947..5603350 [GRCh37]
Chr12:12p13.31
uncertain significance
GRCh37/hg19 12p13.33-13.31(chr12:173786-5737510)x1 copy number loss See cases [RCV000446628] Chr12:173786..5737510 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
GRCh37/hg19 12p13.33-12.2(chr12:173786-20026080)x3 copy number gain See cases [RCV000446050] Chr12:173786..20026080 [GRCh37]
Chr12:12p13.33-12.2
pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:173786-8257049)x3 copy number gain See cases [RCV000446749] Chr12:173786..8257049 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:189578-34756150) copy number gain See cases [RCV000446017] Chr12:189578..34756150 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:565369-34835837)x3 copy number gain See cases [RCV000511580] Chr12:565369..34835837 [GRCh37]
Chr12:12p13.33-11.1
likely pathogenic
GRCh37/hg19 12p13.33-13.2(chr12:173786-11677456)x3 copy number gain See cases [RCV000510853] Chr12:173786..11677456 [GRCh37]
Chr12:12p13.33-13.2
pathogenic
GRCh37/hg19 12p13.33-11.22(chr12:173786-28219229)x3 copy number gain See cases [RCV000510961] Chr12:173786..28219229 [GRCh37]
Chr12:12p13.33-11.22
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x2,3 copy number gain not provided [RCV000683478] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain not provided [RCV000683479] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:173786-6039841)x1 copy number loss not provided [RCV000683475] Chr12:173786..6039841 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:191242-8122785)x3 copy number gain not provided [RCV000683477] Chr12:191242..8122785 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:173786-5952112)x1 copy number loss not provided [RCV000683474] Chr12:173786..5952112 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
GRCh37/hg19 12p13.32-13.31(chr12:4305058-6066141)x1 copy number loss not provided [RCV000683465] Chr12:4305058..6066141 [GRCh37]
Chr12:12p13.32-13.31
likely pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:173786-6201932)x1 copy number loss not provided [RCV000683476] Chr12:173786..6201932 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869107)x3 copy number gain not provided [RCV000683480] Chr12:173786..37869107 [GRCh37]
Chr12:12p13.33-q11
pathogenic
NM_001102654.2(NTF3):c.266G>A (p.Gly89Glu) single nucleotide variant Hirschsprung disease [RCV000736041] Chr12:5494441 [GRCh38]
Chr12:5603607 [GRCh37]
Chr12:12p13.31
likely benign
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-11.21(chr12:191619-31733044)x3 copy number gain not provided [RCV000750245] Chr12:191619..31733044 [GRCh37]
Chr12:12p13.33-11.21
pathogenic
GRCh37/hg19 12p13.31(chr12:5550738-5690626)x3 copy number gain not provided [RCV000750265] Chr12:5550738..5690626 [GRCh37]
Chr12:12p13.31
benign
GRCh37/hg19 12p13.31(chr12:5550738-5690885)x3 copy number gain not provided [RCV000750266] Chr12:5550738..5690885 [GRCh37]
Chr12:12p13.31
benign
GRCh37/hg19 12p13.31(chr12:5577867-5626158)x3 copy number gain not provided [RCV000750267] Chr12:5577867..5626158 [GRCh37]
Chr12:12p13.31
benign
NM_001102654.2(NTF3):c.585C>T (p.Gly195=) single nucleotide variant not provided [RCV000921748] Chr12:5494760 [GRCh38]
Chr12:5603926 [GRCh37]
Chr12:12p13.31
benign
GRCh37/hg19 12p13.33-12.3(chr12:189216-15001420) copy number gain not provided [RCV000767817] Chr12:189216..15001420 [GRCh37]
Chr12:12p13.33-12.3
pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:237588-8278292) copy number gain not provided [RCV000767818] Chr12:237588..8278292 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:189216-8185497) copy number gain not provided [RCV000767819] Chr12:189216..8185497 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
NM_001102654.2(NTF3):c.726A>G (p.Ser242=) single nucleotide variant not provided [RCV000965881] Chr12:5494901 [GRCh38]
Chr12:5604067 [GRCh37]
Chr12:12p13.31
benign
NC_000012.12:g.(1_3750000)_(5250000_9000000)del deletion Hyperphosphatemic familial tumoral calcinosis 1 [RCV000758697] Chr12:3750000..5250000 [GRCh38]
Chr12:12p13.33-13.31
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34496628)x3 copy number gain not provided [RCV000847209] Chr12:173786..34496628 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:173786-8393815)x3 copy number gain not provided [RCV000846343] Chr12:173786..8393815 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:173786-6346092)x1 copy number loss not provided [RCV000847821] Chr12:173786..6346092 [GRCh37]
Chr12:12p13.33-13.31
pathogenic
NM_001102654.2(NTF3):c.648C>T (p.Asn216=) single nucleotide variant not provided [RCV000961178] Chr12:5494823 [GRCh38]
Chr12:5603989 [GRCh37]
Chr12:12p13.31
benign
GRCh37/hg19 12p13.33-q11(chr12:274676-37869301)x4 copy number gain not provided [RCV001006470] Chr12:274676..37869301 [GRCh37]
Chr12:12p13.33-q11
pathogenic
NM_001102654.2(NTF3):c.309C>T (p.Thr103=) single nucleotide variant not provided [RCV000890515] Chr12:5494484 [GRCh38]
Chr12:5603650 [GRCh37]
Chr12:12p13.31
benign
NC_000012.11:g.(?_4479509)_(6235003_?)dup duplication Episodic ataxia type 1 [RCV001294847] Chr12:4479509..6235003 [GRCh37]
Chr12:12p13.32-13.31
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8023 AgrOrtholog
COSMIC NTF3 COSMIC
Ensembl Genes ENSG00000185652 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000328738 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000397297 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000331010 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000423158 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
GTEx ENSG00000185652 GTEx
HGNC ID HGNC:8023 ENTREZGENE
Human Proteome Map NTF3 Human Proteome Map
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Nerve_growth_factor-like UniProtKB/Swiss-Prot
  Nerve_growth_factor-rel UniProtKB/Swiss-Prot
  Nerve_growth_factor_CS UniProtKB/Swiss-Prot
  Neurotrophin-3 UniProtKB/Swiss-Prot
KEGG Report hsa:4908 UniProtKB/Swiss-Prot
NCBI Gene 4908 ENTREZGENE
OMIM 162660 OMIM
PANTHER PTHR11589 UniProtKB/Swiss-Prot
  PTHR11589:SF4 UniProtKB/Swiss-Prot
Pfam NGF UniProtKB/Swiss-Prot
PharmGKB PA31806 PharmGKB
PIRSF NGF UniProtKB/Swiss-Prot
PRINTS NEUROTROPHN3 UniProtKB/Swiss-Prot
  NGF UniProtKB/Swiss-Prot
PROSITE NGF_1 UniProtKB/Swiss-Prot
  NGF_2 UniProtKB/Swiss-Prot
SMART NGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt NTF3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B7Z1T5 UniProtKB/Swiss-Prot
  Q6FH50 UniProtKB/Swiss-Prot