MIR200C (microRNA 200c) - Rat Genome Database

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Gene: MIR200C (microRNA 200c) Homo sapiens
Analyze
Symbol: MIR200C
Name: microRNA 200c
RGD ID: 1353057
HGNC Page HGNC:31580
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including negative regulation of calcium ion import across plasma membrane; negative regulation of gene expression; and positive regulation of cell differentiation. Predicted to be part of RISC complex. Biomarker of colorectal cancer.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-200c; MIRN200C
RGD Orthologs
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,963,699 - 6,963,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,963,699 - 6,963,766 (+)EnsemblGRCh38hg38GRCh38
GRCh37127,072,862 - 7,072,929 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,943,122 - 6,943,189 (+)NCBINCBI36Build 36hg18NCBI36
Celera128,693,881 - 8,693,948 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,931,327 - 6,931,394 (+)NCBIHuRef
CHM1_1127,071,815 - 7,071,882 (+)NCBICHM1_1
T2T-CHM13v2.0126,977,174 - 6,977,241 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Regulation of trabecular meshwork cell contraction and intraocular pressure by miR-200c. Luna C, etal., PLoS One. 2012;7(12):e51688. doi: 10.1371/journal.pone.0051688. Epub 2012 Dec 14.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. miR200c attenuates P-gp-mediated MDR and metastasis by targeting JNK2/c-Jun signaling pathway in colorectal cancer. Sui H, etal., Mol Cancer Ther. 2014 Dec;13(12):3137-51. doi: 10.1158/1535-7163.MCT-14-0167. Epub 2014 Sep 9.
4. Correlation analysis of miR-200b, miR-200c, and miR-141 with liver metastases in colorectal cancer patients. Zhu SH, etal., Eur Rev Med Pharmacol Sci. 2017 May;21(10):2357-2363.
Additional References at PubMed
PMID:14573789   PMID:15183728   PMID:16381832   PMID:17604727   PMID:17616659   PMID:17804704   PMID:18381893   PMID:19502803   PMID:19665978   PMID:19801681   PMID:20084174   PMID:20514023  
PMID:20620960   PMID:20696752   PMID:21037258   PMID:21051560   PMID:21224847   PMID:21224848   PMID:21237487   PMID:21248297   PMID:21345725   PMID:21501518   PMID:21516486   PMID:21527937  
PMID:21873159   PMID:21899661   PMID:22015043   PMID:22100809   PMID:22101791   PMID:22144583   PMID:22183793   PMID:22223089   PMID:22364742   PMID:22384255   PMID:22407310   PMID:22522429  
PMID:22562822   PMID:22615771   PMID:22641662   PMID:22685266   PMID:22707408   PMID:22735571   PMID:22954417   PMID:22982443   PMID:22991189   PMID:23041061   PMID:23065816   PMID:23185507  
PMID:23394580   PMID:23455327   PMID:23546450   PMID:23574937   PMID:23584475   PMID:23617747   PMID:23635949   PMID:23708087   PMID:23754305   PMID:23765923   PMID:23788640   PMID:23821457  
PMID:23824089   PMID:23838916   PMID:23872359   PMID:23888967   PMID:23938772   PMID:23950995   PMID:23982750   PMID:23995857   PMID:24039897   PMID:24135722   PMID:24143167   PMID:24186205  
PMID:24204560   PMID:24205206   PMID:24259014   PMID:24365599   PMID:24368337   PMID:24376848   PMID:24390222   PMID:24424572   PMID:24512620   PMID:24615544   PMID:24647918   PMID:24658157  
PMID:24682933   PMID:24710933   PMID:24755559   PMID:24821285   PMID:24830724   PMID:24885194   PMID:24966949   PMID:24997798   PMID:25003366   PMID:25017995   PMID:25044403   PMID:25052237  
PMID:25058589   PMID:25124149   PMID:25178837   PMID:25200917   PMID:25277203   PMID:25279428   PMID:25305131   PMID:25329395   PMID:25363395   PMID:25367080   PMID:25422078   PMID:25445393  
PMID:25502084   PMID:25636451   PMID:25644713   PMID:25683382   PMID:25703910   PMID:25725128   PMID:25738863   PMID:25746005   PMID:25766530   PMID:25791170   PMID:25798833   PMID:25798844  
PMID:25808651   PMID:25826661   PMID:25832648   PMID:25840984   PMID:25860934   PMID:25885099   PMID:25903073   PMID:25955258   PMID:25967125   PMID:25986864   PMID:26002553   PMID:26025631  
PMID:26035744   PMID:26063644   PMID:26079153   PMID:26179333   PMID:26203557   PMID:26208390   PMID:26248649   PMID:26260454   PMID:26261532   PMID:26302069   PMID:26334100   PMID:26335822  
PMID:26392416   PMID:26400206   PMID:26400441   PMID:26517683   PMID:26662382   PMID:26822089   PMID:26887353   PMID:26910180   PMID:26943577   PMID:27090737   PMID:27094812   PMID:27105531  
PMID:27113480   PMID:27122240   PMID:27153322   PMID:27155790   PMID:27183614   PMID:27198154   PMID:27309544   PMID:27315529   PMID:27402080   PMID:27432063   PMID:27460529   PMID:27498672  
PMID:27529418   PMID:27565378   PMID:27666124   PMID:27693631   PMID:27717206   PMID:27753009   PMID:27835595   PMID:27995756   PMID:28008308   PMID:28029649   PMID:28075045   PMID:28112443  
PMID:28113080   PMID:28163188   PMID:28411308   PMID:28431233   PMID:28436302   PMID:28436968   PMID:28459373   PMID:28529643   PMID:28534959   PMID:28567416   PMID:28587302   PMID:28609841  
PMID:28611183   PMID:28637482   PMID:28664228   PMID:28675952   PMID:28691020   PMID:28727734   PMID:28745318   PMID:28811385   PMID:28829888   PMID:28837147   PMID:28846829   PMID:28882646  
PMID:28910345   PMID:28910745   PMID:28914881   PMID:28933253   PMID:28981169   PMID:29044995   PMID:29051585   PMID:29080395   PMID:29084210   PMID:29113749   PMID:29116025   PMID:29162923  
PMID:29170124   PMID:29171334   PMID:29286062   PMID:29302045   PMID:29321091   PMID:29331391   PMID:29355888   PMID:29373717   PMID:29388209   PMID:29394133   PMID:29461619   PMID:29496312  
PMID:29532351   PMID:29593314   PMID:29630744   PMID:29656186   PMID:29660303   PMID:29710475   PMID:29751044   PMID:29778524   PMID:29871889   PMID:29917193   PMID:29958727   PMID:30066855  
PMID:30138915   PMID:30209363   PMID:30213797   PMID:30215459   PMID:30226594   PMID:30231924   PMID:30272330   PMID:30280784   PMID:30301603   PMID:30352575   PMID:30366960   PMID:30389857  
PMID:30431444   PMID:30440128   PMID:30459436   PMID:30500775   PMID:30518916   PMID:30584245   PMID:30670688   PMID:30851420   PMID:30923833   PMID:30941952   PMID:31017046   PMID:31061665  
PMID:31077198   PMID:31152447   PMID:31194576   PMID:31194976   PMID:31222825   PMID:31240993   PMID:31288577   PMID:31346357   PMID:31372646   PMID:31421682   PMID:31429770   PMID:31535411  
PMID:31599500   PMID:31615875   PMID:31635993   PMID:31747409   PMID:31801690   PMID:31827114   PMID:31877303   PMID:31898520   PMID:31929856   PMID:32069773   PMID:32179097   PMID:32198770  
PMID:32214346   PMID:32310826   PMID:32313093   PMID:32417760   PMID:32495886   PMID:32497621   PMID:32626945   PMID:32633351   PMID:32708601   PMID:32795593   PMID:32826250   PMID:32901847  
PMID:32918341   PMID:32960511   PMID:32990223   PMID:33040228   PMID:33122632   PMID:33125708   PMID:33174523   PMID:33208870   PMID:33472424   PMID:33596640   PMID:33601073   PMID:33654197  
PMID:33673143   PMID:33852640   PMID:34071861   PMID:34153234   PMID:34243729   PMID:34245265   PMID:34301766   PMID:34368370   PMID:34524611   PMID:34534238   PMID:34543800   PMID:34573382  
PMID:34625660   PMID:34676879   PMID:34732818   PMID:34753799   PMID:34783290   PMID:34981333   PMID:35028929   PMID:35079913   PMID:35145164   PMID:35235816   PMID:35299961   PMID:35456497  
PMID:35595718   PMID:35607288   PMID:35713481   PMID:35822676   PMID:36040437   PMID:36067091   PMID:36076930   PMID:36078082   PMID:36316365   PMID:36499397   PMID:36614110   PMID:36896567  


Genomics

Comparative Map Data
MIR200C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,963,699 - 6,963,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,963,699 - 6,963,766 (+)EnsemblGRCh38hg38GRCh38
GRCh37127,072,862 - 7,072,929 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,943,122 - 6,943,189 (+)NCBINCBI36Build 36hg18NCBI36
Celera128,693,881 - 8,693,948 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,931,327 - 6,931,394 (+)NCBIHuRef
CHM1_1127,071,815 - 7,071,882 (+)NCBICHM1_1
T2T-CHM13v2.0126,977,174 - 6,977,241 (+)NCBIT2T-CHM13v2.0
Mir200c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,695,285 - 124,695,353 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,695,285 - 124,695,353 (-)EnsemblGRCm39 Ensembl
GRCm386124,718,322 - 124,718,390 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,718,322 - 124,718,390 (-)EnsemblGRCm38mm10GRCm38
MGSCv376124,668,340 - 124,668,408 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera6126,400,047 - 126,400,115 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Mir200c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,209,965 - 159,210,033 (-)NCBIGRCr8
mRatBN7.24157,523,679 - 157,523,747 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx4163,752,169 - 163,752,237 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,535,074 - 159,535,142 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,176,638 - 158,176,706 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,236,786 - 157,236,854 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,254,382 - 224,254,450 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4146,262,341 - 146,262,409 (-)NCBICelera
Cytogenetic Map4q42NCBI
MIR200C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,082,097 - 38,082,159 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,082,091 - 38,082,169 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,534,531 - 8,534,593 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,434,697 - 38,434,759 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12738,309,579 - 38,309,641 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,350,560 - 38,350,622 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,013,294 - 8,013,356 (+)NCBIUU_Cfam_GSD_1.0


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-11.22(chr12:121055-28415184)x1 copy number loss See cases [RCV000052776] Chr12:121055..28415184 [GRCh38]
Chr12:282465..28568117 [GRCh37]
Chr12:100482..28459384 [NCBI36]
Chr12:12p13.33-11.22		 pathogenic
GRCh38/hg38 12p13.31(chr12:6728665-7705620)x1 copy number loss See cases [RCV000052779] Chr12:6728665..7705620 [GRCh38]
Chr12:6837831..7858216 [GRCh37]
Chr12:6708092..7749483 [NCBI36]
Chr12:12p13.31		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:77187-34380176)x3 copy number gain See cases [RCV000053660] Chr12:77187..34380176 [GRCh38]
Chr12:282465..34533111 [GRCh37]
Chr12:56614..34424378 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-12.1(chr12:80412-25470329)x3 copy number gain See cases [RCV000053662] Chr12:80412..25470329 [GRCh38]
Chr12:282465..25623263 [GRCh37]
Chr12:59839..25514530 [NCBI36]
Chr12:12p13.33-12.1		 pathogenic
GRCh38/hg38 12p13.33-13.31(chr12:121055-7272606)x3 copy number gain See cases [RCV000053663] Chr12:121055..7272606 [GRCh38]
Chr12:282465..7425202 [GRCh37]
Chr12:100482..7316469 [NCBI36]
Chr12:12p13.33-13.31		 pathogenic
GRCh38/hg38 12p13.33-13.31(chr12:121255-8361746)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053664]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053664]|See cases [RCV000053664] Chr12:121255..8361746 [GRCh38]
Chr12:282465..8514342 [GRCh37]
Chr12:100682..8405609 [NCBI36]
Chr12:12p13.33-13.31		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:212976-33926913)x4 copy number gain See cases [RCV000053666] Chr12:212976..33926913 [GRCh38]
Chr12:322142..34079848 [GRCh37]
Chr12:192403..33971115 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
NC_000012.11:g.(?_6945914)_(9027627_?)dup duplication Developmental and epileptic encephalopathy, 21 [RCV001325295]|Klippel-Feil syndrome 3, autosomal dominant [RCV001301079]|Temtamy syndrome [RCV000816630]|not provided [RCV001859243] Chr12:6945914..9027627 [GRCh37]
Chr12:12p13.31		 uncertain significance|no classifications from unflagged records
GRCh38/hg38 12p13.33-11.1(chr12:121255-34603274)x3 copy number gain See cases [RCV000136611] Chr12:121255..34603274 [GRCh38]
Chr12:282465..34756209 [GRCh37]
Chr12:100682..34647476 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-12.3(chr12:2871741-14987348)x3 copy number gain See cases [RCV000137694] Chr12:2871741..14987348 [GRCh38]
Chr12:2980907..15140282 [GRCh37]
Chr12:2851168..15031549 [NCBI36]
Chr12:12p13.33-12.3		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121271-34603261)x3 copy number gain See cases [RCV000139052] Chr12:121271..34603261 [GRCh38]
Chr12:282465..34756196 [GRCh37]
Chr12:100698..34647463 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:54427-34608071)x4 copy number gain See cases [RCV000139787] Chr12:54427..34608071 [GRCh38]
Chr12:282465..34761006 [GRCh37]
Chr12:33854..34652273 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh38/hg38 12p13.33-12.2(chr12:1258274-20657577)x3 copy number gain See cases [RCV000141905] Chr12:1258274..20657577 [GRCh38]
Chr12:1367440..20810511 [GRCh37]
Chr12:1237701..20701778 [NCBI36]
Chr12:12p13.33-12.2		 pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:64620-34682902)x4 copy number gain See cases [RCV000142149] Chr12:64620..34682902 [GRCh38]
Chr12:173786..34835837 [GRCh37]
Chr12:44047..34727104 [NCBI36]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:148034-34178799)x4 copy number gain See cases [RCV000240164] Chr12:148034..34178799 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:89061-34178799)x3 copy number gain See cases [RCV000240487] Chr12:89061..34178799 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301)x3 copy number gain See cases [RCV000449191] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865)x3 copy number gain See cases [RCV000449287] Chr12:173786..25286865 [GRCh37]
Chr12:12p13.33-12.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain See cases [RCV000447551] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.31(chr12:7069980-7094188)x3 copy number gain See cases [RCV000447567] Chr12:7069980..7094188 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.33-12.2(chr12:173786-20026080)x3 copy number gain See cases [RCV000446050] Chr12:173786..20026080 [GRCh37]
Chr12:12p13.33-12.2		 pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:173786-8257049)x3 copy number gain See cases [RCV000446749] Chr12:173786..8257049 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:189578-34756150) copy number gain See cases [RCV000446017] Chr12:189578..34756150 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:565369-34835837)x3 copy number gain See cases [RCV000511580] Chr12:565369..34835837 [GRCh37]
Chr12:12p13.33-11.1		 likely pathogenic
GRCh37/hg19 12p13.33-13.2(chr12:173786-11677456)x3 copy number gain See cases [RCV000510853] Chr12:173786..11677456 [GRCh37]
Chr12:12p13.33-13.2		 pathogenic
GRCh37/hg19 12p13.33-11.22(chr12:173786-28219229)x3 copy number gain See cases [RCV000510961] Chr12:173786..28219229 [GRCh37]
Chr12:12p13.33-11.22		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain not provided [RCV000683479] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x2,3 copy number gain not provided [RCV000683478] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:191242-8122785)x3 copy number gain not provided [RCV000683477] Chr12:191242..8122785 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869107)x3 copy number gain not provided [RCV000683480] Chr12:173786..37869107 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-11.21(chr12:191619-31733044)x3 copy number gain not provided [RCV000750245] Chr12:191619..31733044 [GRCh37]
Chr12:12p13.33-11.21		 pathogenic
GRCh37/hg19 12p13.31(chr12:6911437-9381254)x3 copy number gain not provided [RCV000750277] Chr12:6911437..9381254 [GRCh37]
Chr12:12p13.31		 uncertain significance
NC_000012.11:g.(?_6945914)_(8248706_?)dup duplication Temtamy syndrome [RCV001031096] Chr12:6945914..8248706 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.33-q11(chr12:274676-37869301)x4 copy number gain not provided [RCV001006470] Chr12:274676..37869301 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
GRCh37/hg19 12p13.33-12.3(chr12:189216-15001420) copy number gain not provided [RCV000767817] Chr12:189216..15001420 [GRCh37]
Chr12:12p13.33-12.3		 pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:189216-8185497) copy number gain not provided [RCV000767819] Chr12:189216..8185497 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
NC_000012.12:g.(1_3750000)_(5250000_9000000)del deletion Tumoral calcinosis, hyperphosphatemic, familial, 1 [RCV000758697] Chr12:3750000..5250000 [GRCh38]
Chr12:12p13.33-13.31		 pathogenic|not provided
GRCh37/hg19 12p13.33-13.31(chr12:237588-8278292) copy number gain not provided [RCV000767818] Chr12:237588..8278292 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
NC_000012.11:g.(?_6945914)_(9027627_?)dup duplication Temtamy syndrome [RCV000816630] Chr12:6945914..9027627 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.33-13.31(chr12:173786-8393815)x3 copy number gain not provided [RCV000846343] Chr12:173786..8393815 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34496628)x3 copy number gain not provided [RCV000847209] Chr12:173786..34496628 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
NC_000012.11:g.(?_4368352)_(9027607_?)dup duplication Lymphoproliferative syndrome 2 [RCV003105682] Chr12:4368352..9027607 [GRCh37]
Chr12:12p13.32-13.31		 uncertain significance
NC_000012.11:g.(?_6438458)_(7362839_?)dup duplication Peroxisome biogenesis disorder 2B [RCV001031288] Chr12:6438458..7362839 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.33-13.31(chr12:189145-7730395)x3 copy number gain not provided [RCV001537906] Chr12:189145..7730395 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
NC_000012.11:g.(?_6438478)_(7362819_?)dup duplication Temtamy syndrome [RCV001365174] Chr12:6438478..7362819 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.33-13.31(chr12:146240-8330229)x3 copy number gain Obesity [RCV001801197] Chr12:146240..8330229 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
NC_000012.11:g.(?_6438478)_(8248686_?)dup duplication Temtamy syndrome [RCV003120743]|not provided [RCV001913769] Chr12:6438478..8248686 [GRCh37]
Chr12:12p13.31		 uncertain significance|no classifications from unflagged records
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865) copy number gain not specified [RCV002052955] Chr12:173786..25286865 [GRCh37]
Chr12:12p13.33-12.1		 pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301) copy number gain not specified [RCV002052958] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11		 pathogenic
NC_000012.11:g.(?_6438478)_(8756953_?)dup duplication not provided [RCV001970781] Chr12:6438478..8756953 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.31(chr12:6872634-7244086) copy number gain not specified [RCV002052969] Chr12:6872634..7244086 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837) copy number gain not specified [RCV002052957] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.31(chr12:6530146-7376398) copy number gain not specified [RCV002052968] Chr12:6530146..7376398 [GRCh37]
Chr12:12p13.31		 uncertain significance
NC_000012.11:g.(?_6978008)_(9010204_?)dup duplication Peroxisome biogenesis disorder 2B [RCV001877402] Chr12:6978008..9010204 [GRCh37]
Chr12:12p13.31		 uncertain significance
NC_000012.11:g.(?_6438478)_(9027607_?)dup duplication not provided [RCV001943267] Chr12:6438478..9027607 [GRCh37]
Chr12:12p13.31		 uncertain significance
NC_000012.11:g.(?_6945914)_(7362819_?)dup duplication not provided [RCV001943326] Chr12:6945914..7362819 [GRCh37]
Chr12:12p13.31		 uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:176047-34179852)x4 copy number gain Pallister-Killian syndrome [RCV003154827] Chr12:176047..34179852 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-13.31(chr12:173787-8320544)x3 copy number gain not provided [RCV002472514] Chr12:173787..8320544 [GRCh37]
Chr12:12p13.33-13.31		 pathogenic
Single allele duplication not provided [RCV003448692] Chr12:188053..34856694 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835641)x3 copy number gain not specified [RCV003986979] Chr12:173786..34835641 [GRCh37]
Chr12:12p13.33-11.1		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
TUBB3hsa-miR-200c-3pMirtarbaseexternal_infoELISA//Immunoblot//Immunocytochemistry//LuciferaseFunctional MTI19435871
TUBB3hsa-miR-200c-3pMirtarbaseexternal_infoWestern blotFunctional MTI20049172
BMI1hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19665978
BMI1hsa-miR-200c-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI21294122
BMI1hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI21207483
MSNhsa-miR-200c-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCR//WeFunctional MTI21501518
ZEB2hsa-miR-200c-3pMirtarbaseexternal_infoReporter assayFunctional MTI18381893
BAP1hsa-miR-200c-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17875710
BAP1hsa-miR-200c-3pMirtarbaseexternal_infoReporter assayFunctional MTI20005803
ZEB2hsa-miR-200c-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI18381893
ZEB2hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19839049
ZEB2hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19854497
ZEB2hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20620960
ZEB2hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21049046
ZEB2hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22569286
BRD7hsa-miR-200c-3pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//MFunctional MTI22015043
ZEB1hsa-miR-200c-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI18483486
ZEB1hsa-miR-200c-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI18381893
ZEB1hsa-miR-200c-3pMirtarbaseexternal_infoimmunoblot//Luciferase reporter assay//qRT-PCR//WeFunctional MTI20049172
ZEB1hsa-miR-200c-3pMirtarbaseexternal_infoqRT-PCR//qRT-PCR;OtherFunctional MTI (Weak)19502803
ZEB1hsa-miR-200c-3pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCRFunctional MTI (Weak)21224848
ZEB1hsa-miR-200c-3pMirtarbaseexternal_infoGFP reporter assay//qRT-PCRFunctional MTI16929162
ZEB1hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22407310
ZEB1hsa-miR-200c-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
ERRFI1hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19671845
ACVR2Bhsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22431721
ZEB1hsa-miR-200c-3pMirtarbaseexternal_infoimmunohistochemistry//Microarray//qRT-PCR//WesternFunctional MTI19167416
ZEB2hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRNon-Functional MTI18411277
EP300hsa-miR-200c-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19569050
ZFPM2hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI20005803
XIAPhsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21993663
UBE2Ihsa-miR-200c-3pMirtarbaseexternal_infoqRT-PCR//Western blotNon-Functional MTI19223510
PTPN13hsa-miR-200c-3pMirtarbaseexternal_infoFACS//Luciferase reporter assay//qRT-PCR//Western Functional MTI20620960
CCNE2hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22183793
TBK1hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22991189
PMAIP1hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22615771
NTF3hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23185507
LPAR1hsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23272142
GEMIN2hsa-miR-200c-3pTarbaseexternal_infoReporter GenePOSITIVE
ZEB1hsa-miR-200c-3pTarbaseexternal_infoqPCRPOSITIVE
ZEB1hsa-miR-200c-3pTarbaseexternal_infoOtherPOSITIVE
ZEB1hsa-miR-200c-3pTarbaseexternal_infoWesternblitPOSITIVE
ZEB1hsa-miR-200c-3pOncomiRDBexternal_infoNANA23436804
TUBB3hsa-miR-200c-3pOncomiRDBexternal_infoNANA23394580
NTRK2hsa-miR-200c-3pOncomiRDBexternal_infoNANA23209748
BMI1hsa-miR-200c-3pOncomiRDBexternal_infoNANA22982443
NCAM1hsa-miR-200c-3pOncomiRDBexternal_infoNANA22707408
ZEB1hsa-miR-200c-3pOncomiRDBexternal_infoNANA22685266
ZEB1hsa-miR-200c-3pOncomiRDBexternal_infoNANA22569286
ACVR2Bhsa-miR-200c-3pOncomiRDBexternal_infoNANA22431721
ZEB1hsa-miR-200c-3pOncomiRDBexternal_infoNANA22407310
SNAI2hsa-miR-200c-3pOncomiRDBexternal_infoNANA22370643
CCNE2hsa-miR-200c-3pOncomiRDBexternal_infoNANA22183793
FHOD1hsa-miR-200c-3pOncomiRDBexternal_infoNANA22144583
MYBL2hsa-miR-200c-3pOncomiRDBexternal_infoNANA22101269
BCL2hsa-miR-200c-3pOncomiRDBexternal_infoNANA21993663
SEC23Ahsa-miR-200c-3pOncomiRDBexternal_infoNANA21822286
SEC23Ahsa-miR-200c-3pOncomiRDBexternal_infoNANA21593139
FN1hsa-miR-200c-3pOncomiRDBexternal_infoNANA21501518
BMI1hsa-miR-200c-3pOncomiRDBexternal_infoNANA21294122
JAG1hsa-miR-200c-3pOncomiRDBexternal_infoNANA21224848
JAG1hsa-miR-200c-3pOncomiRDBexternal_infoNANA21224847
BMI1hsa-miR-200c-3pOncomiRDBexternal_infoNANA21207483
FLT1hsa-miR-200c-3pOncomiRDBexternal_infoNANA21115742
NOTCH1hsa-miR-200c-3pOncomiRDBexternal_infoNANA20805998
PTPN13hsa-miR-200c-3pOncomiRDBexternal_infoNANA20620960
BMI1hsa-miR-200c-3pOncomiRDBexternal_infoNANA19935649
ZEB1hsa-miR-200c-3pOncomiRDBexternal_infoNANA19854497
ZEB1hsa-miR-200c-3pOncomiRDBexternal_infoNANA19839049
WASF3hsa-miR-200c-3pOncomiRDBexternal_infoNANA19801681
ERRFI1hsa-miR-200c-3pOncomiRDBexternal_infoNANA19671845
BMI1hsa-miR-200c-3pOncomiRDBexternal_infoNANA19665978
TUBB3hsa-miR-200c-3pOncomiRDBexternal_infoNANA19435871
TGFB2hsa-miR-200c-3pOncomiRDBexternal_infoNANA18483486
ZEB1hsa-miR-200c-3pOncomiRDBexternal_infoNANA18381893
ZEB1hsa-miR-200c-3pOncomiRDBexternal_infoNANA18376396
ZEB1hsa-miR-200c-5pMirecordsexternal_info{changed}NA18483486
ZFPM2hsa-miR-200c-5pMirecordsexternal_infoNANA20005803
ERRFI1hsa-miR-200c-5pMirecordsexternal_infoNANA19671845
ZEB1hsa-miR-200c-5pMirecordsexternal_info{changed}NA19502803
JAG1hsa-miR-200c-5pMirecordsexternal_info{unchanged}NA21224847

Predicted Targets
Summary Value
Count of predictions:21752
Count of gene targets:8653
Count of transcripts:16513
Interacting mature miRNAs:hsa-miR-200c-3p, hsa-miR-200c-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1 1 1 14 3
Low 106 37 44 8 40 9 82 23 37 15 121 138 8 15 46 2
Below cutoff 17 15 9 3 14 4 28 24 26 6 4 12 3 19

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384980
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl126,963,699 - 6,963,766 (+)Ensembl
RefSeq Acc Id: NR_029779
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,963,699 - 6,963,766 (+)NCBI
GRCh37127,072,862 - 7,072,929 (+)ENTREZGENE
HuRef126,931,327 - 6,931,394 (+)ENTREZGENE
CHM1_1127,071,815 - 7,071,882 (+)NCBI
T2T-CHM13v2.0126,977,174 - 6,977,241 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31580 AgrOrtholog
COSMIC MIR200C COSMIC
Ensembl Genes ENSG00000207713 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384980 ENTREZGENE
GTEx ENSG00000207713 GTEx
HGNC ID HGNC:31580 ENTREZGENE
Human Proteome Map MIR200C Human Proteome Map
miRBase MI0000650 ENTREZGENE
NCBI Gene 406985 ENTREZGENE
OMIM 612092 OMIM
PharmGKB PA164722577 PharmGKB
RNAcentral URS0000171525 RNACentral
  URS0000192F9C RNACentral
  URS0000346F1C RNACentral