Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: HAND2 (heart and neural crest derivatives expressed 2) Homo sapiens
Analyze
Symbol: HAND2
Name: heart and neural crest derivatives expressed 2
Description: Exhibits AT DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and E-box binding activity. Predicted to contribute to transcription regulatory region DNA binding activity. Involved in several processes, including adult heart development; positive regulation of MAPK cascade; and regulation of gene expression. Localizes to the nuclear chromatin and protein-containing complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basic helix-loop-helix transcription factor HAND2; bHLHa26; class A basic helix-loop-helix protein 26; deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHand; DHAND2; FLJ16260; heart- and neural crest derivatives-expressed protein 2; Hed; MGC125303; MGC125304; Thing2
Orthologs:
Mus musculus (house mouse) : Hand2 (heart and neural crest derivatives expressed 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hand2 (heart and neural crest derivatives expressed 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hand2 (heart and neural crest derivatives expressed 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HAND2 (heart and neural crest derivatives expressed 2)
Canis lupus familiaris (dog) : HAND2 (heart and neural crest derivatives expressed 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hand2 (heart and neural crest derivatives expressed 2)
Sus scrofa (pig) : HAND2 (heart and neural crest derivatives expressed 2)
Chlorocebus sabaeus (African green monkey) : HAND2 (heart and neural crest derivatives expressed 2)
Heterocephalus glaber (naked mole-rat) : Hand2 (heart and neural crest derivatives expressed 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl4173,524,969 - 173,530,229 (-)Ensembl
GRCh384173,526,091 - 173,530,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374174,447,652 - 174,451,378 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364174,684,227 - 174,687,953 (-)NCBINCBI36hg18NCBI36
Build 344174,820,849 - 174,825,309NCBI
Celera4171,772,735 - 171,776,461 (-)NCBI
Cytogenetic Map4q34.1NCBI
HuRef4170,194,314 - 170,197,710 (-)NCBIHuRef
CHM1_14174,424,466 - 174,428,102 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on HAND2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731603
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.