CCR6 (C-C motif chemokine receptor 6) - Rat Genome Database

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Gene: CCR6 (C-C motif chemokine receptor 6) Homo sapiens
Analyze
Symbol: CCR6
Name: C-C motif chemokine receptor 6
RGD ID: 1318406
HGNC Page HGNC
Description: Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in calcium-mediated signaling; cell chemotaxis; and positive regulation of flagellated sperm motility involved in capacitation. Located in cell surface; sperm flagellum; and sperm plasma membrane. Biomarker of several diseases, including IgA glomerulonephritis; exanthem; primary cutaneous T-cell non-Hodgkin lymphoma; psoriasis; and systemic scleroderma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: BN-1; C-C chemokine receptor type 6; C-C CKR-6; CC-CKR-6; CCR-6; CD196; chemokine (C-C motif) receptor 6; chemokine (C-C) receptor 6; chemokine receptor-like 3; CKR-L3; CKR6; CKRL3; CMKBR6; DCR2; DRY-6; DRY6; G protein-coupled receptor 29; G-protein coupled receptor 29; GPR-CY4; GPR29; GPRCY4; LARC receptor; seven-transmembrane receptor, lymphocyte, 22; STRL22
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386167,111,795 - 167,139,141 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6167,111,807 - 167,139,141 (+)EnsemblGRCh38hg38GRCh38
GRCh376167,525,283 - 167,552,629 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366167,445,285 - 167,472,619 (+)NCBINCBI36hg18NCBI36
Build 346167,506,667 - 167,523,040NCBI
Celera6168,267,636 - 168,294,982 (+)NCBI
Cytogenetic Map6q27NCBI
HuRef6164,997,922 - 165,025,262 (+)NCBIHuRef
CHM1_16167,787,685 - 167,815,011 (+)NCBICHM1_1
T2T-CHM13v2.06168,494,454 - 168,521,816 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-naphthylamine  (EXP)
3,7-dihydropurine-6-thione  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
antirheumatic drug  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
asperentin  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
chloropicrin  (EXP)
cyclosporin A  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
ethanol  (ISO)
folic acid  (ISO)
furan  (ISO)
irinotecan  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
mercaptopurine  (ISO)
methylarsonic acid  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
neoechinulin A  (ISO)
nickel atom  (EXP)
nickel sulfate  (ISO)
nicotine  (EXP)
paracetamol  (EXP)
paraoxon  (EXP)
prostaglandin E2  (EXP)
purine-6-thiol  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
rifampicin  (EXP)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sterigmatocystin  (ISO)
testosterone  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichostatin A  (EXP)
urethane  (EXP)
valproic acid  (EXP)
zinc dichloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Ayers CM, etal., Int Forum Allergy Rhinol. 2011 Jul-Aug;1(4):296-302. doi: 10.1002/alr.20046. Epub 2011 Apr 11.
2. Prognostic value of the expression of C-Chemokine Receptor 6 and 7 and their ligands in non-metastatic breast cancer. Cassier PA, etal., BMC Cancer. 2011 May 30;11:213. doi: 10.1186/1471-2407-11-213.
3. Cytokine and chemokine expression in the skin from patients with maculopapular exanthema to drugs. Fernandez TD, etal., Allergy. 2008 Jun;63(6):712-9. doi: 10.1111/j.1398-9995.2007.01607.x. Epub 2008 Mar 29.
4. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
5. CCR6 is required for IL-23-induced psoriasis-like inflammation in mice. Hedrick MN, etal., J Clin Invest. 2009 Aug;119(8):2317-29.
6. Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. Homey B, etal., J Immunol. 2000 Jun 15;164(12):6621-32.
7. Expression profile of chemokines and chemokine receptors in epithelial cell layers of oral lichen planus. Ichimura M, etal., J Oral Pathol Med. 2006 Mar;35(3):167-74.
8. CCR6 selectively promotes monocyte mediated inflammation and atherogenesis in mice. Manthey HD, etal., Thromb Haemost. 2013 Nov 27;110(6):1267-77. doi: 10.1160/TH13-01-0017. Epub 2013 Oct 10.
9. Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury. McTigue DM, etal., J Neurosci Res. 1998 Aug 1;53(3):368-76.
10. IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma. Miyagaki T, etal., Clin Cancer Res. 2011 Dec 15;17(24):7529-38. doi: 10.1158/1078-0432.CCR-11-1192. Epub 2011 Nov 2.
11. The role of CC chemokine receptor 6 in host defense in a model of invasive pulmonary aspergillosis. Phadke AP, etal., Am J Respir Crit Care Med. 2007 Jun 1;175(11):1165-72. Epub 2007 Mar 22.
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Fms-like tyrosine kinase 3 ligand regulates migratory pattern and antigen uptake of lung dendritic cell subsets in a murine model of allergic airway inflammation. Shao Z, etal., J Immunol. 2009 Dec 1;183(11):7531-8. doi: 10.4049/jimmunol.0901341. Epub 2009 Nov 16.
14. Corneal epithelial cells and stromal keratocytes efficently produce CC chemokine-ligand 20 (CCL20) and attract cells expressing its receptor CCR6 in mouse herpetic stromal keratitis. Shirane J, etal., Curr Eye Res. 2004 May;28(5):297-306.
15. Up-regulation of CC chemokine ligand 20 and its receptor CCR6 in the lesional skin of early systemic sclerosis. Tao J, etal., Eur J Dermatol. 2011 Sep-Oct;21(5):731-6. doi: 10.1684/ejd.2011.1469.
16. Macrophage inflammatory protein-3alpha plays a key role in the inflammatory cascade in rat focal cerebral ischemia. Terao Y, etal., Neurosci Res. 2009 May;64(1):75-82. doi: 10.1016/j.neures.2009.01.017. Epub 2009 Feb 13.
17. Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms. Villa L, etal., J Pathol. 2013 Apr;229(5):672-84. doi: 10.1002/path.4151. Epub 2013 Mar 5.
Additional References at PubMed
PMID:2834384   PMID:8125298   PMID:8886020   PMID:9070937   PMID:9169459   PMID:9186513   PMID:9223454   PMID:9294137   PMID:9294138   PMID:10521347   PMID:11001880   PMID:11164896  
PMID:11714836   PMID:11751947   PMID:11994436   PMID:12067311   PMID:12070001   PMID:12081481   PMID:12149255   PMID:12193700   PMID:12477932   PMID:12514792   PMID:12642342   PMID:14574404  
PMID:15483227   PMID:15489334   PMID:15591779   PMID:15701269   PMID:15972662   PMID:16095490   PMID:16215992   PMID:16344560   PMID:16621978   PMID:16622267   PMID:16641550   PMID:17075975  
PMID:17133360   PMID:17171755   PMID:17562763   PMID:17615381   PMID:18097022   PMID:18218038   PMID:18240029   PMID:18465142   PMID:18577758   PMID:18587394   PMID:18703490   PMID:19233848  
PMID:19249008   PMID:19305396   PMID:19324905   PMID:19423540   PMID:19492413   PMID:19539215   PMID:19760754   PMID:19811428   PMID:20022113   PMID:20023216   PMID:20056178   PMID:20068036  
PMID:20194631   PMID:20220766   PMID:20334681   PMID:20379614   PMID:20406964   PMID:20438785   PMID:20439195   PMID:20453841   PMID:20453842   PMID:20459729   PMID:20483750   PMID:20511548  
PMID:20526339   PMID:20526340   PMID:20570966   PMID:20634891   PMID:20720211   PMID:20872189   PMID:21072187   PMID:21092675   PMID:21102463   PMID:21228329   PMID:21261017   PMID:21300824  
PMID:21398606   PMID:21724701   PMID:21763254   PMID:21873313   PMID:21873635   PMID:21912453   PMID:21935436   PMID:21937703   PMID:21949768   PMID:21984702   PMID:22079021   PMID:22092173  
PMID:22269120   PMID:22490506   PMID:22527137   PMID:22732549   PMID:22796894   PMID:22842622   PMID:22859539   PMID:22926920   PMID:23128233   PMID:23306142   PMID:23599932   PMID:23681234  
PMID:23758411   PMID:23765988   PMID:23790181   PMID:23823618   PMID:23835793   PMID:23850713   PMID:23935994   PMID:23959575   PMID:23983073   PMID:24133439   PMID:24162774   PMID:24385540  
PMID:24390342   PMID:24394994   PMID:24401998   PMID:24559209   PMID:24634224   PMID:24743888   PMID:24782177   PMID:24866282   PMID:24886709   PMID:24890729   PMID:24958901   PMID:24979261  
PMID:24980635   PMID:24984269   PMID:25113059   PMID:25122636   PMID:25178112   PMID:25201147   PMID:25408215   PMID:25541254   PMID:25661365   PMID:25690781   PMID:25698534   PMID:25768730  
PMID:25833398   PMID:25879557   PMID:25928629   PMID:26125463   PMID:26138531   PMID:26156805   PMID:26314374   PMID:26345847   PMID:26489425   PMID:26536229   PMID:26577851   PMID:26771764  
PMID:26789110   PMID:26883727   PMID:27016283   PMID:27018255   PMID:27149649   PMID:27587881   PMID:27626929   PMID:27789680   PMID:27916417   PMID:28206670   PMID:28298427   PMID:28392462  
PMID:28444576   PMID:29097259   PMID:29126851   PMID:29262350   PMID:29268566   PMID:29440351   PMID:29535421   PMID:29552015   PMID:29981781   PMID:30287142   PMID:30412323   PMID:30728405  
PMID:31322256   PMID:31432181   PMID:31866467   PMID:32184325   PMID:32412043   PMID:32541785   PMID:32600091   PMID:32634857   PMID:32739204   PMID:33113266   PMID:33381579   PMID:33717080  
PMID:33768543   PMID:33961781   PMID:34225700   PMID:34400521   PMID:34497608   PMID:34719426   PMID:34774095   PMID:34864633   PMID:34873687  


Genomics

Comparative Map Data
CCR6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386167,111,795 - 167,139,141 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6167,111,807 - 167,139,141 (+)EnsemblGRCh38hg38GRCh38
GRCh376167,525,283 - 167,552,629 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366167,445,285 - 167,472,619 (+)NCBINCBI36hg18NCBI36
Build 346167,506,667 - 167,523,040NCBI
Celera6168,267,636 - 168,294,982 (+)NCBI
Cytogenetic Map6q27NCBI
HuRef6164,997,922 - 165,025,262 (+)NCBIHuRef
CHM1_16167,787,685 - 167,815,011 (+)NCBICHM1_1
T2T-CHM13v2.06168,494,454 - 168,521,816 (+)NCBI
Ccr6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39178,454,875 - 8,477,353 (+)NCBIGRCm39mm39
GRCm39 Ensembl178,454,875 - 8,475,973 (+)Ensembl
GRCm38178,236,041 - 8,258,519 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl178,236,043 - 8,257,141 (+)EnsemblGRCm38mm10GRCm38
MGSCv37178,428,908 - 8,450,006 (+)NCBIGRCm37mm9NCBIm37
MGSCv36178,080,700 - 8,095,301 (+)NCBImm8
Celera178,276,953 - 8,300,589 (+)NCBICelera
Cytogenetic Map17A1NCBI
Ccr6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2152,474,477 - 52,508,301 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl152,474,168 - 52,498,603 (-)Ensembl
Rnor_6.0153,063,380 - 53,087,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,065,025 - 53,087,474 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0154,311,531 - 54,335,218 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4147,115,472 - 47,139,825 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1147,118,424 - 47,142,770 (-)NCBI
Celera148,238,928 - 48,261,505 (-)NCBICelera
Cytogenetic Map1q12NCBI
Ccr6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543914,920,601 - 14,924,191 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543914,921,524 - 14,949,493 (-)NCBIChiLan1.0ChiLan1.0
CCR6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16170,069,689 - 170,084,779 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6170,069,689 - 170,084,779 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06165,094,563 - 165,109,774 (+)NCBIMhudiblu_PPA_v0panPan3
CCR6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1154,932,798 - 54,960,646 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl154,932,690 - 54,959,740 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha155,722,381 - 55,750,218 (+)NCBI
ROS_Cfam_1.0155,113,648 - 55,141,502 (+)NCBI
UMICH_Zoey_3.1155,010,269 - 55,038,459 (+)NCBI
UNSW_CanFamBas_1.0154,859,036 - 54,886,902 (+)NCBI
UU_Cfam_GSD_1.0155,484,239 - 55,512,089 (+)NCBI
Ccr6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946149,431,750 - 149,438,723 (+)NCBI
SpeTri2.0NW_00493648916,669,297 - 16,689,451 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCR6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12,018,608 - 2,019,821 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.112,016,600 - 2,034,172 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CCR6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11394,865,480 - 94,894,331 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1394,865,936 - 94,894,315 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604066,673,826 - 66,688,967 (+)NCBIVero_WHO_p1.0
Ccr6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478512,190,802 - 12,203,924 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH46835  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376167,550,947 - 167,551,093UniSTSGRCh37
Build 366167,470,937 - 167,471,083RGDNCBI36
Celera6168,293,300 - 168,293,446RGD
Cytogenetic Map6q27UniSTS
HuRef6165,023,579 - 165,023,725UniSTS
GeneMap99-GB4 RH Map6630.13UniSTS
NCBI RH Map61662.8UniSTS
SHGC-105352  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376167,529,742 - 167,530,052UniSTSGRCh37
Build 366167,449,732 - 167,450,042RGDNCBI36
Celera6168,272,083 - 168,272,393RGD
Cytogenetic Map6q27UniSTS
HuRef6165,002,369 - 165,002,679UniSTS
TNG Radiation Hybrid Map227196.0UniSTS
PMC135988P8  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376167,549,901 - 167,550,304UniSTSGRCh37
Build 366167,469,891 - 167,470,294RGDNCBI36
Celera6168,292,254 - 168,292,657RGD
Cytogenetic Map6q27UniSTS
HuRef6165,022,533 - 165,022,936UniSTS
CCR6_1762  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376167,551,814 - 167,552,643UniSTSGRCh37
Build 366167,471,804 - 167,472,633RGDNCBI36
Celera6168,294,167 - 168,294,996RGD
HuRef6165,024,446 - 165,025,276UniSTS
STS-U68030  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376167,550,846 - 167,551,058UniSTSGRCh37
Build 366167,470,836 - 167,471,048RGDNCBI36
Celera6168,293,199 - 168,293,411RGD
Cytogenetic Map6q27UniSTS
HuRef6165,023,478 - 165,023,690UniSTS
GeneMap99-GB4 RH Map6636.73UniSTS
NCBI RH Map61631.6UniSTS
RH70644  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376167,550,850 - 167,551,046UniSTSGRCh37
Build 366167,470,840 - 167,471,036RGDNCBI36
Celera6168,293,203 - 168,293,399RGD
Cytogenetic Map6q27UniSTS
HuRef6165,023,482 - 165,023,678UniSTS
GeneMap99-GB4 RH Map6636.79UniSTS
NCBI RH Map61672.4UniSTS
D8S2279  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map21q22.12UniSTS
Cytogenetic Map15q13UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map15q22.3UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map3p22-p21.3UniSTS
Cytogenetic Map1q21.1UniSTS
Cytogenetic Map2q24.2UniSTS
Cytogenetic Map17q24.2UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map7p14.1UniSTS
Cytogenetic Map2q22.3UniSTS
Cytogenetic Map15q13.2UniSTS
Cytogenetic Map12q24.1UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map2p25.2UniSTS
Cytogenetic Map3p24.3UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map5q14UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map1q42.12UniSTS
Cytogenetic Map7q21.11UniSTS
Cytogenetic Map9q34.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map6p21.1-p12UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map7p21.3UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map22q11.22UniSTS
Cytogenetic Map11p13UniSTS
Cytogenetic Map1q12UniSTS
Cytogenetic Map8p23UniSTS
Cytogenetic Map11q13.2-q13.3UniSTS
Cytogenetic Map13q14.1-q14.3UniSTS
Cytogenetic Map3q22-q24UniSTS
Cytogenetic Map3q13.1-q13.2UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map5q23.3-q31.1UniSTS
Cytogenetic Map8p21.3UniSTS
Cytogenetic Map14q32.3UniSTS
Cytogenetic Map7q11.23UniSTS
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Cytogenetic Map13q13.3UniSTS
Cytogenetic Map10p12.31UniSTS
Cytogenetic Map22q11.1UniSTS
Cytogenetic Map5q33.2UniSTS
Cytogenetic Map13q32.2UniSTS
Cytogenetic Map14q23.1UniSTS
Cytogenetic Map8q21.2UniSTS
Cytogenetic Map2q24.1UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map2q23.3UniSTS
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map15q14-q15UniSTS
Cytogenetic Map1q42.13UniSTS
Cytogenetic Map14q31UniSTS
Cytogenetic Map7p21.1UniSTS
Cytogenetic Map8p12-p11UniSTS
Cytogenetic Map18p11.2UniSTS
Cytogenetic Map7p11.1UniSTS
Cytogenetic Map1q31-q32UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map3p21.32UniSTS
Cytogenetic Map2p24.2UniSTS
Cytogenetic Map2q33-q34UniSTS
Cytogenetic Map6q24.1UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map15q13.3UniSTS
Cytogenetic Map10q26.11UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map10q23.33UniSTS
Cytogenetic Map12p12.1UniSTS
Cytogenetic Map7p13-p12UniSTS
Cytogenetic MapXq25UniSTS
Cytogenetic Map17q11-q21UniSTS
Cytogenetic Map12q23UniSTS
Cytogenetic Map6p24-p22.3UniSTS
Cytogenetic Map14q23.2UniSTS
Cytogenetic Map7q31.1-q31.2UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map15q21.2UniSTS
Cytogenetic Map3p26.1-p25.1UniSTS
Cytogenetic Map5q35UniSTS
Cytogenetic Map3q13.2UniSTS
Cytogenetic Map4p15.2UniSTS
Cytogenetic Map6q16.3UniSTS
Cytogenetic Map17q24-q25UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic MapXq27.1UniSTS
Cytogenetic Map8q12.3UniSTS
Cytogenetic Map5q21.2UniSTS
Cytogenetic Map5q15UniSTS
Cytogenetic Map5q35.1UniSTS
Cytogenetic Map4q13.3UniSTS
Cytogenetic Map4q35.2UniSTS
Cytogenetic Map3p26.1UniSTS
Cytogenetic Map3p11.1UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map2q21.2UniSTS
Cytogenetic Map19p13.13UniSTS
Cytogenetic Map18q12.3UniSTS
Cytogenetic Map18p11.3UniSTS
Cytogenetic Map17q11.1UniSTS
Cytogenetic Map15q25.1UniSTS
Cytogenetic Map13q12.3UniSTS
Cytogenetic Map12q23.2UniSTS
Cytogenetic Map12q12-q13UniSTS
Cytogenetic Map12q14UniSTS
Cytogenetic Map5q33.1UniSTS
Cytogenetic Map2q32-q34UniSTS
Cytogenetic Map16q22.3UniSTS
Cytogenetic Map2p15-p13UniSTS
Cytogenetic MapXp11.4UniSTS
Cytogenetic Map19q13.33-q13.41UniSTS
Cytogenetic Map20p11UniSTS
Cytogenetic Map6q23-q24UniSTS
Cytogenetic Map2p12UniSTS
Cytogenetic Map2p13UniSTS
Cytogenetic Map13q11-q12UniSTS
Cytogenetic Map6p12.3-p11.2UniSTS
Cytogenetic Map6q16.1-q16.3UniSTS
Cytogenetic Map22q11UniSTS
Cytogenetic Map7q31.2UniSTS
Cytogenetic Map10q21.3UniSTS
Cytogenetic Map3q25.2UniSTS
Cytogenetic Map3p21.1-p14.3UniSTS
Cytogenetic Map6p12.1UniSTS
Cytogenetic Map3q23-q24UniSTS
Cytogenetic Map3q12UniSTS
Cytogenetic Map7q11.1UniSTS
Cytogenetic Map3q22.3UniSTS
Cytogenetic Map7q21.3UniSTS
Cytogenetic Map4q31.1UniSTS
Cytogenetic Map22q12-q13UniSTS
Cytogenetic Map4q23UniSTS
Cytogenetic MapXp22.12UniSTS
Cytogenetic Map6q16.1UniSTS
Cytogenetic Map13q14.13UniSTS
Cytogenetic Map18q21.3UniSTS
Cytogenetic Map9q33.2UniSTS
Cytogenetic Map11q21UniSTS
Cytogenetic Map8q12UniSTS
Cytogenetic Map4q28-q32UniSTS
Cytogenetic Map17q24.3UniSTS
Cytogenetic Map6p23UniSTS
Cytogenetic Map8p11UniSTS
Cytogenetic Map5q34UniSTS
Cytogenetic Map1q24.3UniSTS
Cytogenetic Map9q33.1UniSTS
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map2p16.2UniSTS
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map9p24.3UniSTS
Cytogenetic Map7q35UniSTS
Cytogenetic Map1p36.2UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map16p12UniSTS
Cytogenetic Map1q22-q23UniSTS
Cytogenetic Map13q22.1UniSTS
Cytogenetic Map2q12.2UniSTS
Cytogenetic Map8p12UniSTS
Cytogenetic Map4q21UniSTS
Cytogenetic Map13q12.2UniSTS
Cytogenetic Map9q31-q33UniSTS
Cytogenetic Map6p24.1UniSTS
Cytogenetic Map1q23UniSTS
Cytogenetic Map11q12-q13UniSTS
Cytogenetic Map11q13.3UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map11q12.1UniSTS
Cytogenetic Map3p26UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map8p21UniSTS
Cytogenetic Map19q13.1-q13.2UniSTS
Cytogenetic Map1p33-p32UniSTS
Cytogenetic Map7q36.2UniSTS
Cytogenetic Map4q32.3UniSTS
Cytogenetic Map16p13.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map10q26.1UniSTS
Cytogenetic Map9q32-q33.3UniSTS
Cytogenetic Map9q22.1-q22.2UniSTS
Cytogenetic Map3q26.1-q26.2UniSTS
Cytogenetic Map5q31-q34UniSTS
Cytogenetic Map9q33-q34UniSTS
Cytogenetic Map5q11.2-q13.2UniSTS
Cytogenetic Map13q32UniSTS
Cytogenetic Map9q22.32UniSTS
Cytogenetic Map1p36.3UniSTS
Cytogenetic Map1p36.3-p36.2UniSTS
Cytogenetic Map4q28.1UniSTS
Cytogenetic Map5q22UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic MapXq13.3UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map3p26.3UniSTS
Cytogenetic Map2q11.1UniSTS
Cytogenetic Map21q11.2UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map15q26.2UniSTS
Cytogenetic Map12q24.23UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map20p12.1UniSTS
Cytogenetic Map2q31.1-q31.2UniSTS
Cytogenetic MapXp22.31UniSTS
Cytogenetic MapXp21.3UniSTS
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map4q28.2UniSTS
Cytogenetic Map3p14.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map20q13.2UniSTS
Cytogenetic Map14q11.2-q12UniSTS
Cytogenetic Map3p24UniSTS
Cytogenetic Map12q23.3UniSTS
Cytogenetic Map11q24.3UniSTS
Cytogenetic Map11q14.3UniSTS
Cytogenetic Map10q25.2UniSTS
Cytogenetic Map3q25.1UniSTS
Cytogenetic Map8q13UniSTS
Cytogenetic Map1p22.2UniSTS
Cytogenetic Map3p22.3UniSTS
Cytogenetic Map18q11.1UniSTS
Cytogenetic Map8q23.3UniSTS
Cytogenetic Map15q24UniSTS
Cytogenetic Map11cen-q12UniSTS
Cytogenetic Map11q25UniSTS
Cytogenetic Map3p22.2UniSTS
Cytogenetic MapXp21.1UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map12q21UniSTS
Cytogenetic Map7p15UniSTS
Cytogenetic Map7q22-q31UniSTS
Cytogenetic Map11q22UniSTS
Cytogenetic Map5p15.3UniSTS
Cytogenetic Map20q13.3-qterUniSTS
Cytogenetic Map1p35-p34UniSTS
Cytogenetic Map4p13-p12UniSTS
Cytogenetic Map10q21-q22UniSTS
Cytogenetic Map4q22UniSTS
Cytogenetic Map7p13-p11.1UniSTS
Cytogenetic Map9q31-q34UniSTS
Cytogenetic Map7q21.1-q22UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map3q13.13-q13.2UniSTS
Cytogenetic MapXp22.13UniSTS
Cytogenetic Map13q12.12UniSTS
Cytogenetic Map13q14.2UniSTS
Cytogenetic Map12qUniSTS
Cytogenetic Map1pUniSTS
Cytogenetic Map16pUniSTS
Cytogenetic Map15qUniSTS
Cytogenetic Map7qUniSTS
Cytogenetic Map2qUniSTS
Cytogenetic Map5q13.1UniSTS
Cytogenetic Map11p14.1UniSTS
Cytogenetic Map4q32UniSTS
Cytogenetic Map2p22UniSTS
Cytogenetic Map5q14.3UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map5q23.2UniSTS
Cytogenetic Map2p24.1UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map12p13.32UniSTS
Cytogenetic Map9p21.1UniSTS
Cytogenetic Map9q34.2-q34.3UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1822
Count of miRNA genes:559
Interacting mature miRNAs:605
Transcripts:ENST00000341935, ENST00000349984, ENST00000400926
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage pharyngeal arch
High
Medium 69 2 2 1 234 1 1
Low 499 669 745 55 1191 27 771 21 1062 63 527 1053 29 193 369 2
Below cutoff 1737 2142 810 437 359 303 2983 1713 2482 161 678 289 134 1006 2109

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001394582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK223494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL121935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY242126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD692892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD707633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA645096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN996219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U45984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U68030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U68031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U68032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z79784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000341935   ⟹   ENSP00000343952
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6167,123,096 - 167,139,141 (+)Ensembl
RefSeq Acc Id: ENST00000349984   ⟹   ENSP00000339393
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6167,122,771 - 167,138,946 (+)Ensembl
RefSeq Acc Id: ENST00000400926   ⟹   ENSP00000383715
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6167,111,807 - 167,139,141 (+)Ensembl
RefSeq Acc Id: ENST00000643861   ⟹   ENSP00000493637
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6167,120,866 - 167,137,657 (+)Ensembl
RefSeq Acc Id: ENST00000646493   ⟹   ENSP00000495402
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6167,111,807 - 167,136,695 (+)Ensembl
RefSeq Acc Id: NM_001394582   ⟹   NP_001381511
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386167,122,753 - 167,139,141 (+)NCBI
T2T-CHM13v2.06168,505,411 - 168,521,816 (+)NCBI
Sequence:
RefSeq Acc Id: NM_004367   ⟹   NP_004358
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386167,111,795 - 167,139,141 (+)NCBI
GRCh376167,525,295 - 167,554,168 (+)NCBI
Build 366167,445,285 - 167,472,619 (+)NCBI Archive
HuRef6164,997,922 - 165,025,262 (+)ENTREZGENE
CHM1_16167,787,685 - 167,815,011 (+)NCBI
T2T-CHM13v2.06168,494,454 - 168,521,816 (+)NCBI
Sequence:
RefSeq Acc Id: NM_031409   ⟹   NP_113597
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386167,123,096 - 167,139,141 (+)NCBI
GRCh376167,525,295 - 167,554,168 (+)NCBI
Build 366167,456,231 - 167,472,619 (+)NCBI Archive
HuRef6164,997,922 - 165,025,262 (+)ENTREZGENE
CHM1_16167,798,624 - 167,815,011 (+)NCBI
T2T-CHM13v2.06168,505,754 - 168,521,816 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_004358   ⟸   NM_004367
- UniProtKB: P51684 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_113597   ⟸   NM_031409
- UniProtKB: P51684 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000339393   ⟸   ENST00000349984
RefSeq Acc Id: ENSP00000383715   ⟸   ENST00000400926
RefSeq Acc Id: ENSP00000493637   ⟸   ENST00000643861
RefSeq Acc Id: ENSP00000343952   ⟸   ENST00000341935
RefSeq Acc Id: ENSP00000495402   ⟸   ENST00000646493
RefSeq Acc Id: NP_001381511   ⟸   NM_001394582

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51684-F1-model_v2 AlphaFold P51684 1-374 view protein structure

Promoters
RGD ID:7209661
Promoter ID:EPDNEW_H10575
Type:initiation region
Name:CCR6_2
Description:C-C motif chemokine receptor 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10576  EPDNEW_H10577  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386167,111,798 - 167,111,858EPDNEW
RGD ID:7209659
Promoter ID:EPDNEW_H10576
Type:multiple initiation site
Name:CCR6_1
Description:C-C motif chemokine receptor 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10575  EPDNEW_H10577  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386167,122,753 - 167,122,813EPDNEW
RGD ID:7209663
Promoter ID:EPDNEW_H10577
Type:initiation region
Name:CCR6_3
Description:C-C motif chemokine receptor 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10576  EPDNEW_H10575  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386167,123,096 - 167,123,156EPDNEW
RGD ID:6803878
Promoter ID:HG_KWN:55772
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:NM_004367
Position:
Human AssemblyChrPosition (strand)Source
Build 366167,445,079 - 167,445,579 (+)MPROMDB
RGD ID:6803879
Promoter ID:HG_KWN:55773
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:OTTHUMT00000043118,   UC003QVM.2
Position:
Human AssemblyChrPosition (strand)Source
Build 366167,455,541 - 167,456,687 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q24.1-27(chr6:141132990-169339571)x3 copy number gain See cases [RCV000050604] Chr6:141132990..169339571 [GRCh38]
Chr6:141454127..169739666 [GRCh37]
Chr6:141495820..169481591 [NCBI36]
Chr6:6q24.1-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170583214)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|See cases [RCV000051902] Chr6:152376338..170583214 [GRCh38]
Chr6:152697473..170892302 [GRCh37]
Chr6:152739166..170734227 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:158664768-170612001)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051904]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051904]|See cases [RCV000051904] Chr6:158664768..170612001 [GRCh38]
Chr6:159085800..170921089 [GRCh37]
Chr6:159005788..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:154118058-170602152)x1 copy number loss See cases [RCV000052207] Chr6:154118058..170602152 [GRCh38]
Chr6:154439193..170911240 [GRCh37]
Chr6:154480885..170753165 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:159454639-170612001)x1 copy number loss See cases [RCV000052209] Chr6:159454639..170612001 [GRCh38]
Chr6:159875671..170921089 [GRCh37]
Chr6:159795661..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:159825913-170612001)x1 copy number loss See cases [RCV000052211] Chr6:159825913..170612001 [GRCh38]
Chr6:160246945..170921089 [GRCh37]
Chr6:160166935..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:160328288-170612001)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052212]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052212]|See cases [RCV000052212] Chr6:160328288..170612001 [GRCh38]
Chr6:160749320..170921089 [GRCh37]
Chr6:160669310..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:160359686-170608818)x1 copy number loss See cases [RCV000052213] Chr6:160359686..170608818 [GRCh38]
Chr6:160780718..170917906 [GRCh37]
Chr6:160700708..170759831 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:160422761-170612001)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052214]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052214]|See cases [RCV000052214] Chr6:160422761..170612001 [GRCh38]
Chr6:160843793..170921089 [GRCh37]
Chr6:160763783..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q26-27(chr6:161205328-170581161)x1 copy number loss See cases [RCV000052215] Chr6:161205328..170581161 [GRCh38]
Chr6:161626360..170890249 [GRCh37]
Chr6:161546350..170732174 [NCBI36]
Chr6:6q26-27		 pathogenic
GRCh38/hg38 6q26-27(chr6:162042846-170608818)x1 copy number loss See cases [RCV000052223] Chr6:162042846..170608818 [GRCh38]
Chr6:162463878..170917906 [GRCh37]
Chr6:162383868..170759831 [NCBI36]
Chr6:6q26-27		 pathogenic
GRCh38/hg38 6q26-27(chr6:162789915-170602152)x1 copy number loss See cases [RCV000052224] Chr6:162789915..170602152 [GRCh38]
Chr6:163210947..170911240 [GRCh37]
Chr6:163130937..170753165 [NCBI36]
Chr6:6q26-27		 pathogenic
GRCh38/hg38 6q26-27(chr6:163420224-170608818)x1 copy number loss See cases [RCV000052225] Chr6:163420224..170608818 [GRCh38]
Chr6:163841256..170917906 [GRCh37]
Chr6:163761246..170759831 [NCBI36]
Chr6:6q26-27		 pathogenic
GRCh38/hg38 6q27(chr6:165126489-170581161)x1 copy number loss See cases [RCV000052226] Chr6:165126489..170581161 [GRCh38]
Chr6:165539978..170890249 [GRCh37]
Chr6:165459968..170732174 [NCBI36]
Chr6:6q27		 pathogenic
GRCh38/hg38 6q27(chr6:166370159-170602152)x1 copy number loss See cases [RCV000052227] Chr6:166370159..170602152 [GRCh38]
Chr6:166783647..170911240 [GRCh37]
Chr6:166703637..170753165 [NCBI36]
Chr6:6q27		 pathogenic
GRCh38/hg38 6q27(chr6:166907168-167368489)x3 copy number gain See cases [RCV000053393] Chr6:166907168..167368489 [GRCh38]
Chr6:167320656..167781977 [GRCh37]
Chr6:167240646..167701967 [NCBI36]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6q26-27(chr6:162865436-170901287)x3 copy number gain See cases [RCV000184080] Chr6:162865436..170901287 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:160484810-170612011)x1 copy number loss See cases [RCV000134021] Chr6:160484810..170612011 [GRCh38]
Chr6:160905842..170921099 [GRCh37]
Chr6:160825832..170763024 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q27(chr6:164790270-170612001)x1 copy number loss See cases [RCV000135415] Chr6:164790270..170612001 [GRCh38]
Chr6:165203779..170921089 [GRCh37]
Chr6:165123769..170763014 [NCBI36]
Chr6:6q27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:154539655-170714507)x1 copy number loss See cases [RCV000137381] Chr6:154539655..170714507 [GRCh38]
Chr6:154860789..171023595 [GRCh37]
Chr6:154902481..170865520 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:159915390-170714507)x1 copy number loss See cases [RCV000139636] Chr6:159915390..170714507 [GRCh38]
Chr6:160336422..171023595 [GRCh37]
Chr6:160256412..170865520 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152793402-170610394)x1 copy number loss See cases [RCV000141880] Chr6:152793402..170610394 [GRCh38]
Chr6:153114537..170919482 [GRCh37]
Chr6:153156230..170761407 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170612001)x3 copy number gain See cases [RCV000142594] Chr6:152376338..170612001 [GRCh38]
Chr6:152697473..170921089 [GRCh37]
Chr6:152739166..170763014 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q26-27(chr6:160899898-170610394)x1 copy number loss See cases [RCV000143619] Chr6:160899898..170610394 [GRCh38]
Chr6:161320930..170919482 [GRCh37]
Chr6:161240920..170761407 [NCBI36]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q27(chr6:165443824-170892302)x1 copy number loss See cases [RCV000239993] Chr6:165443824..170892302 [GRCh37]
Chr6:6q27		 pathogenic
GRCh37/hg19 6q26-27(chr6:162381975-170919482)x1 copy number loss See cases [RCV000449121] Chr6:162381975..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q26-27(chr6:164361517-170919482)x1 copy number loss See cases [RCV000446024] Chr6:164361517..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q25.1-27(chr6:151214792-170892243)x3 copy number gain See cases [RCV000449011] Chr6:151214792..170892243 [GRCh37]
Chr6:6q25.1-27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6q27(chr6:166110423-170919482)x1 copy number loss See cases [RCV000510607] Chr6:166110423..170919482 [GRCh37]
Chr6:6q27		 pathogenic
GRCh37/hg19 6q26-27(chr6:164276935-170919482)x1 copy number loss See cases [RCV000511755] Chr6:164276935..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q27(chr6:165190527-170919482)x1 copy number loss not provided [RCV000682744] Chr6:165190527..170919482 [GRCh37]
Chr6:6q27		 pathogenic
GRCh37/hg19 6q27(chr6:167388817-170919482)x1 copy number loss not provided [RCV000682747] Chr6:167388817..170919482 [GRCh37]
Chr6:6q27		 pathogenic
46,XX,der(6)(q25.1,q28)dn.seq[GRCh37/hg19]der(6)(6pter->6q25.2(+)(154768571)::q25.2(+)(154778901),q25.2(+)154778992::q25.2(-)(154774048),q25.2(-)(154768571)::q25.2(-)(154768571),q25.1(-)(~151443183-151443483))dn complex Coffin-Siris syndrome 1 [RCV000714957] Chr6:151443333..171115067 [GRCh37]
Chr6:6q25.1-27		 pathogenic
GRCh37/hg19 6q25.3-27(chr6:159844762-170919482)x3 copy number gain not provided [RCV000682734] Chr6:159844762..170919482 [GRCh37]
Chr6:6q25.3-27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6q25.1-27(chr6:150284435-170919470)x3 copy number gain not provided [RCV000746100] Chr6:150284435..170919470 [GRCh37]
Chr6:6q25.1-27		 pathogenic
GRCh37/hg19 6q25.3-27(chr6:159155998-171054786)x3 copy number gain not provided [RCV000746132] Chr6:159155998..171054786 [GRCh37]
Chr6:6q25.3-27		 pathogenic
GRCh37/hg19 6q27(chr6:165989942-171054786)x1 copy number loss not provided [RCV000746208] Chr6:165989942..171054786 [GRCh37]
Chr6:6q27		 pathogenic
NM_031409.4(CCR6):c.150G>A (p.Pro50=) single nucleotide variant not provided [RCV000922136] Chr6:167136380 [GRCh38]
Chr6:167549868 [GRCh37]
Chr6:6q27		 likely benign
NM_031409.4(CCR6):c.1106C>T (p.Ala369Val) single nucleotide variant not provided [RCV000880513] Chr6:167137336 [GRCh38]
Chr6:167550824 [GRCh37]
Chr6:6q27		 benign
GRCh37/hg19 6q26-27(chr6:162452035-170919482)x1 copy number loss not provided [RCV001005874] Chr6:162452035..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
Single allele deletion not provided [RCV000768451] Chr6:162966301..170914973 [GRCh37]
Chr6:6q26-27		 likely pathogenic
GRCh37/hg19 6q27(chr6:166517762-170919470) copy number loss not provided [RCV000767664] Chr6:166517762..170919470 [GRCh37]
Chr6:6q27		 pathogenic
GRCh37/hg19 6q26-27(chr6:162661108-170919482)x1 copy number loss not provided [RCV001005878] Chr6:162661108..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q27(chr6:167440417-170919482)x1 copy number loss not provided [RCV001005882] Chr6:167440417..170919482 [GRCh37]
Chr6:6q27		 pathogenic
GRCh37/hg19 6q27(chr6:166607593-170919482)x1 copy number loss not provided [RCV000846415] Chr6:166607593..170919482 [GRCh37]
Chr6:6q27		 pathogenic
NM_031409.4(CCR6):c.477A>G (p.Arg159=) single nucleotide variant not provided [RCV000890707] Chr6:167136707 [GRCh38]
Chr6:167550195 [GRCh37]
Chr6:6q27		 benign
GRCh37/hg19 6q27(chr6:166083476-170919482)x3 copy number gain not provided [RCV001258773] Chr6:166083476..170919482 [GRCh37]
Chr6:6q27		 likely pathogenic
GRCh37/hg19 6q27(chr6:167263995-167774832)x3 copy number gain not provided [RCV001834343] Chr6:167263995..167774832 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6q26-27(chr6:161047873-170919482) copy number loss not specified [RCV002053651] Chr6:161047873..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q26-27(chr6:162212864-170919482) copy number gain not specified [RCV002053652] Chr6:162212864..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q26-27(chr6:163290087-170919482) copy number loss not specified [RCV002053655] Chr6:163290087..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q27(chr6:167317903-170919482) copy number loss not specified [RCV002053659] Chr6:167317903..170919482 [GRCh37]
Chr6:6q27		 pathogenic
GRCh37/hg19 6q26-27(chr6:162381975-170919482) copy number loss not specified [RCV002053653] Chr6:162381975..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1607 AgrOrtholog
COSMIC CCR6 COSMIC
Ensembl Genes ENSG00000112486 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000339393 ENTREZGENE
  ENSP00000339393.4 UniProtKB/Swiss-Prot
  ENSP00000343952 ENTREZGENE
  ENSP00000343952.5 UniProtKB/Swiss-Prot
  ENSP00000383715 ENTREZGENE
  ENSP00000383715.2 UniProtKB/Swiss-Prot
  ENSP00000493637.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000341935 ENTREZGENE
  ENST00000341935.10 UniProtKB/Swiss-Prot
  ENST00000349984 ENTREZGENE
  ENST00000349984.6 UniProtKB/Swiss-Prot
  ENST00000400926 ENTREZGENE
  ENST00000400926.5 UniProtKB/Swiss-Prot
  ENST00000643861.1 UniProtKB/Swiss-Prot
GTEx ENSG00000112486 GTEx
HGNC ID HGNC:1607 ENTREZGENE
Human Proteome Map CCR6 Human Proteome Map
InterPro Chemokine_CCR6 UniProtKB/Swiss-Prot
  Chemokine_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report hsa:1235 UniProtKB/Swiss-Prot
NCBI Gene 1235 ENTREZGENE
OMIM 601835 OMIM
PANTHER PTHR10489:SF611 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB PA26171 PharmGKB
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot
  CHEMOKINER6 UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
UniProt CCR6_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary E1P5C6 UniProtKB/Swiss-Prot
  P78553 UniProtKB/Swiss-Prot
  Q92846 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-21 CCR6  C-C motif chemokine receptor 6    chemokine (C-C motif) receptor 6  Symbol and/or name change 5135510 APPROVED
2011-08-16 CCR6  chemokine (C-C motif) receptor 6  CCR6  chemokine (C-C motif) receptor 6  Symbol and/or name change 5135510 APPROVED