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Gene: PRLR (prolactin receptor) Homo sapiens
Symbol: PRLR
Name: prolactin receptor
Description: Exhibits peptide hormone binding activity and prolactin receptor activity. Involved in activation of Janus kinase activity; activation of transmembrane receptor protein tyrosine kinase activity; and negative regulation of apoptotic process. Localizes to cell surface. Implicated in hyperprolactinemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: delta 4-delta 7/11 truncated prolactin receptor; delta 4-SF1b truncated prolactin receptor; HPRL; hPRL receptor; hPRLrI; MFAB; PRL-R; prolactin receptor delta 7/11; RI-PRLR; secreted prolactin binding protein
Mus musculus (house mouse) : Prlr (prolactin receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prlr (prolactin receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prlr (prolactin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : PRLR (prolactin receptor)
Canis lupus familiaris (dog) : PRLR (prolactin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prlr (prolactin receptor)
Sus scrofa (pig) : PRLR (prolactin receptor)
Chlorocebus sabaeus (African green monkey) : PRLR (prolactin receptor)
Heterocephalus glaber (naked mole-rat) : Prlr (prolactin receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl535,048,756 - 35,230,487 (-)EnsemblGRCh38hg38GRCh38
GRCh38535,048,756 - 35,230,724 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37535,048,861 - 35,230,823 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36535,099,985 - 35,266,334 (-)NCBINCBI36hg18NCBI36
Build 34535,099,984 - 35,266,334NCBI
Celera534,937,982 - 35,112,885 (-)NCBI
Cytogenetic Map5p13.2NCBI
HuRef534,997,595 - 35,179,481 (-)NCBIHuRef
CHM1_1535,051,181 - 35,232,962 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PRLR
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730871
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.