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Gene: SLC5A5 (solute carrier family 5 member 5) Homo sapiens
Symbol: SLC5A5
Name: solute carrier family 5 member 5
Description: Exhibits iodide transmembrane transporter activity. Involved in cellular response to cAMP; cellular response to gonadotropin stimulus; and iodide transport. Localizes to the nucleus. Implicated in congenital hypothyroidism.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Na(+)/I(-)-symporter; NIS; sodium/iodide cotransporter; solute carrier family 5 (sodium iodide symporter), member 5; solute carrier family 5 (sodium/iodide cotransporter), member 5; solute carrier family 5, member 5; TDH1
Mus musculus (house mouse) : Slc5a5 (solute carrier family 5 (sodium iodide symporter), member 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc5a5 (solute carrier family 5 member 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc5a5 (solute carrier family 5 member 5)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC5A5 (solute carrier family 5 member 5)
Canis lupus familiaris (dog) : SLC5A5 (solute carrier family 5 member 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc5a5 (solute carrier family 5 member 5)
Sus scrofa (pig) : SLC5A5 (solute carrier family 5 member 5)
Chlorocebus sabaeus (African green monkey) : SLC5A5 (solute carrier family 5 member 5)
Heterocephalus glaber (naked mole-rat) : Slc5a5 (solute carrier family 5 member 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1917,871,945 - 17,895,174 (+)EnsemblGRCh38hg38GRCh38
GRCh381917,871,394 - 17,895,175 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371917,982,641 - 18,005,983 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,843,782 - 17,865,897 (+)NCBINCBI36hg18NCBI36
Build 341917,843,781 - 17,865,897NCBI
Celera1917,884,497 - 17,907,699 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,548,153 - 17,571,202 (+)NCBIHuRef
CHM1_11917,982,521 - 18,005,714 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SLC5A5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731751
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.