|
G |
Alb |
albumin |
multiple interactions increases expression |
EXP |
7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane inhibits the reaction [Hydrochloric Acid results in increased expression of ALB protein]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of ALB protein] |
CTD |
PMID:15044056 PMID:15607125 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
|
|
G |
Aqp4 |
aquaporin 4 |
increases expression |
EXP |
Hydrochloric Acid results in increased expression of AQP4 protein |
CTD |
PMID:18406487 |
|
NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
|
|
G |
Areg |
amphiregulin |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of AREG mRNA |
CTD |
PMID:15046208 |
|
NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
|
|
G |
Bag3 |
BAG cochaperone 3 |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of BAG3 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
|
|
G |
Bglap |
bone gamma-carboxyglutamate protein |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of BGLAP |
CTD |
PMID:17183249 |
|
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
|
|
G |
Calca |
calcitonin-related polypeptide alpha |
affects response to substance |
EXP |
CALCA protein affects the susceptibility to Hydrochloric Acid |
CTD |
PMID:19483072 |
|
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
|
|
G |
Car3 |
carbonic anhydrase 3 |
multiple interactions |
ISO |
[NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of CAR3 mRNA |
CTD |
PMID:29618784 |
|
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
|
|
G |
Casp1 |
caspase 1 |
increases cleavage |
ISO |
Hydrochloric Acid results in increased cleavage of CASP1 protein |
CTD |
PMID:31900028 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
|
|
G |
Casp3 |
caspase 3 |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of CASP3 protein modified form |
CTD |
PMID:15046208 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of CASP9 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Cat |
catalase |
multiple interactions |
EXP ISO |
CAT protein inhibits the reaction [Hydrochloric Acid results in increased susceptibility to Indomethacin] [Ethanol co-treated with Hydrochloric Acid] results in increased activity of CAT protein; boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of CAT protein] |
CTD |
PMID:1887894 PMID:32531310 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases expression |
EXP |
pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL2 protein] Hydrochloric Acid results in increased expression of CCL2 mRNA; Hydrochloric Acid results in increased expression of CCL2 protein |
CTD |
PMID:16129981 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Ccl4 |
C-C motif chemokine ligand 4 |
increases expression multiple interactions |
EXP |
Hydrochloric Acid results in increased expression of CCL4 mRNA; Hydrochloric Acid results in increased expression of CCL4 protein pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL4 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL4 protein] |
CTD |
PMID:16129981 |
|
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
|
|
G |
Ccna1 |
cyclin A1 |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of CCNA1 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
|
|
G |
Ccnd1 |
cyclin D1 |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of CCND1 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Ccne1 |
cyclin E1 |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of CCNE1 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
|
|
G |
Ccne2 |
cyclin E2 |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of CCNE2 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
|
|
G |
Cd86 |
CD86 molecule |
multiple interactions |
ISO |
Hydrochloric Acid inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Hydrochloric Acid inhibits the reaction [imidazolidinyl urea results in increased expression of CD86 protein] |
CTD |
PMID:29743441 |
|
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
|
|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
affects localization |
ISO |
Hydrochloric Acid affects the localization of CDKN1B protein |
CTD |
PMID:20818264 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
|
|
G |
Chrm3 |
cholinergic receptor, muscarinic 3 |
decreases expression |
EXP |
Hydrochloric Acid results in decreased expression of CHRM3 protein |
CTD |
PMID:20719367 |
|
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
|
|
G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions increases expression |
EXP |
JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL1 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL1 mRNA] Hydrochloric Acid results in increased expression of CXCL1 mRNA; Hydrochloric Acid results in increased expression of CXCL1 protein |
CTD |
PMID:15044056 PMID:16129981 |
|
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
|
|
G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
increases expression multiple interactions |
EXP |
Hydrochloric Acid results in increased expression of CXCL2 mRNA; Hydrochloric Acid results in increased expression of CXCL2 protein pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL2 protein] |
CTD |
PMID:16129981 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
|
|
G |
Cyba |
cytochrome b-245 alpha chain |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of CYBA protein |
CTD |
PMID:31900028 |
|
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
|
|
G |
Cybb |
cytochrome b-245 beta chain |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of CYBB protein |
CTD |
PMID:31900028 |
|
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
|
|
G |
Dpys |
dihydropyrimidinase |
increases expression multiple interactions |
ISO |
Hydrochloric Acid results in increased expression of DPYS mRNA NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of DPYS mRNA] |
CTD |
PMID:29618784 |
|
NCBI chr 7:70,822,648...70,929,255
Ensembl chr 7:70,835,789...70,929,231
|
|
G |
Dusp2 |
dual specificity phosphatase 2 |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of DUSP2 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499
|
|
G |
Dusp8 |
dual specificity phosphatase 8 |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of DUSP8 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921
|
|
G |
E2f5 |
E2F transcription factor 5 |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of E2F5 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990
|
|
G |
Edn1 |
endothelin 1 |
increases expression |
EXP |
Hydrochloric Acid results in increased expression of EDN1 protein |
CTD |
PMID:19262391 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
|
|
G |
Efna4 |
ephrin A4 |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of EFNA4 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 2:174,748,729...174,752,979
Ensembl chr 2:174,748,724...174,752,979
|
|
G |
Egfr |
epidermal growth factor receptor |
multiple interactions increases expression |
EXP |
Celecoxib promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein]; Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein]; Piroxicam promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein] |
CTD |
PMID:15309881 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
|
|
G |
Emp1 |
epithelial membrane protein 1 |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of EMP1 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904
|
|
G |
Fgf2 |
fibroblast growth factor 2 |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of FGF2 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
|
|
G |
Fgfr3 |
fibroblast growth factor receptor 3 |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of FGFR3 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
EXP |
[Hydrochloric Acid co-treated with PGA5 protein] results in increased expression of FOS protein; Capsaicin inhibits the reaction [Hydrochloric Acid results in increased expression of FOS protein]; Hexamethonium inhibits the reaction [Hydrochloric Acid results in increased expression of FOS protein]; SB 222200 affects the reaction [Hydrochloric Acid results in increased expression of FOS mRNA]; vofopitant affects the reaction [Hydrochloric Acid results in increased expression of FOS mRNA] Hydrochloric Acid results in increased expression of FOS mRNA; Hydrochloric Acid results in increased expression of FOS protein |
CTD |
PMID:11730984 PMID:12588467 PMID:12928072 PMID:14750966 PMID:16162281 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
Fosl2 |
FOS like 2, AP-1 transcription factor subunit |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of FOSL2 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
|
|
G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of GADD45A mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions increases expression |
ISO |
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLC mRNA] |
CTD |
PMID:29618784 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions increases expression |
ISO |
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLM mRNA] |
CTD |
PMID:29618784 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
|
|
G |
Gls |
glutaminase |
multiple interactions increases expression |
ISO |
[Hydrochloric Acid results in decreased expression of GLS protein] which results in increased secretion of Ammonia Hydrochloric Acid results in increased expression of GLS mRNA; Hydrochloric Acid results in increased expression of GLS protein |
CTD |
PMID:20719974 PMID:29618784 |
|
NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
|
|
G |
Glul |
glutamate-ammonia ligase |
multiple interactions |
ISO |
Hydrochloric Acid promotes the reaction [RHBG protein mutant form results in decreased expression of GLUL protein] |
CTD |
PMID:20719974 |
|
NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
|
|
G |
Gstm1 |
glutathione S-transferase mu 1 |
multiple interactions increases expression |
ISO |
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GSTM1 mRNA] |
CTD |
PMID:29618784 |
|
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
|
|
G |
Gtpbp2 |
GTP binding protein 2 |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of GTPBP2 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 9:14,813,964...14,823,419
Ensembl chr 9:14,813,964...14,823,241
|
|
G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
ISO |
[NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of HAVCR1 mRNA |
CTD |
PMID:29618784 |
|
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
EXP |
beraprost inhibits the reaction [Hydrochloric Acid results in increased expression of HMOX1 protein]; Capsaicin promotes the reaction [Hydrochloric Acid results in increased expression of HMOX1 protein] |
CTD |
PMID:18617559 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hsf1 |
heat shock transcription factor 1 |
affects response to substance |
ISO |
HSF1 protein affects the susceptibility to Hydrochloric Acid |
CTD |
PMID:17189318 |
|
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
|
|
G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
affects response to substance |
EXP |
HSPA1A protein affects the susceptibility to Hydrochloric Acid |
CTD |
PMID:16945336 |
|
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
|
|
G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
affects response to substance |
EXP |
HSPA1B protein affects the susceptibility to Hydrochloric Acid |
CTD |
PMID:15338365 |
|
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
increases expression multiple interactions |
EXP ISO |
Hydrochloric Acid results in increased expression of ICAM1 mRNA pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of ICAM1 mRNA] Hydrochloric Acid inhibits the reaction [Dinitrochlorobenzene results in increased expression of ICAM1 protein]; Hydrochloric Acid inhibits the reaction [imidazolidinyl urea results in increased expression of ICAM1 protein] |
CTD |
PMID:16129981 PMID:29743441 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Id2 |
inhibitor of DNA binding 2 |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of ID2 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
EXP ISO |
[Celecoxib co-treated with Hydrochloric Acid] results in increased expression of IL1B protein Hydrochloric Acid results in increased expression of IL1B protein [Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein; MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased expression of IL1B mRNA]; MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased expression of IL1B protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein] Hydrochloric Acid results in increased expression of IL1B mRNA; Hydrochloric Acid results in increased expression of IL1B protein |
CTD |
PMID:15309881 PMID:25478868 PMID:31900028 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il5 |
interleukin 5 |
increases expression |
EXP |
Hydrochloric Acid results in increased expression of IL5 protein |
CTD |
PMID:19951613 |
|
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
|
|
G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
EXP ISO |
7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 protein]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 mRNA]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 protein] Hydrochloric Acid results in increased expression of IL6 mRNA; Hydrochloric Acid results in increased expression of IL6 protein [Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL6 protein; MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 mRNA]; MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL6 protein] |
CTD |
PMID:11850527 PMID:12771618 PMID:15044056 PMID:15607125 PMID:19951613 PMID:25478868 PMID:31900028 More...
|
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Kcna4 |
potassium voltage-gated channel subfamily A member 4 |
decreases activity decreases expression |
EXP |
Hydrochloric Acid results in decreased activity of KCNA4 protein Hydrochloric Acid results in decreased expression of KCNA4 protein |
CTD |
PMID:19279288 |
|
NCBI chr 3:93,756,399...93,778,004
Ensembl chr 3:93,756,446...93,769,162
|
|
G |
Kdm5b |
lysine demethylase 5B |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of KDM5B mRNA |
CTD |
PMID:15046208 |
|
NCBI chr13:46,001,589...46,073,868
Ensembl chr13:46,002,542...46,073,872
|
|
G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of MCL1 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
|
|
G |
Mcm4 |
minichromosome maintenance complex component 4 |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of MCM4 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144
|
|
G |
Mif |
macrophage migration inhibitory factor |
increases expression |
EXP |
Hydrochloric Acid results in increased expression of MIF mRNA; Hydrochloric Acid results in increased expression of MIF protein |
CTD |
PMID:12853844 |
|
NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
|
|
G |
Mmp1 |
matrix metallopeptidase 1 |
increases expression |
EXP |
Hydrochloric Acid results in increased expression of MMP1 protein |
CTD |
PMID:11850527 |
|
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
|
|
G |
Mpo |
myeloperoxidase |
increases activity multiple interactions |
EXP ISO |
Hydrochloric Acid results in increased activity of MPO protein [Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein; [Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein; [lupeol binds to stearic acid] inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein]; baicalein inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein]; Omeprazole inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein] |
CTD |
PMID:11574821 PMID:15309881 PMID:25478868 PMID:27780710 PMID:31900028 PMID:32006539 PMID:32531310 More...
|
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Ncf2 |
neutrophil cytosolic factor 2 |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of NCF2 protein |
CTD |
PMID:31900028 |
|
NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases localization increases response to substance multiple interactions |
EXP ISO |
Hydrochloric Acid results in increased localization of NFE2L2 protein NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of CAR3 mRNA; [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of HAVCR1 mRNA; [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC38A1 mRNA; [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC9A4 mRNA; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC38A4 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC3A2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC7A9 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of CYP2A5 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of DPYS mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLM mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GSTA3 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GSTM1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA]; NFE2L2 protein promotes the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA] |
CTD |
PMID:18617559 PMID:29618784 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of NLRP3 protein |
CTD |
PMID:31900028 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions affects response to substance increases expression |
EXP ISO |
pimagedine inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]; S-methylisothiopseudouronium inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein] NOS2 protein affects the susceptibility to Hydrochloric Acid |
CTD |
PMID:11574821 PMID:12646421 PMID:12771618 PMID:18573544 PMID:24122261 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nos3 |
nitric oxide synthase 3 |
decreases expression |
EXP |
Hydrochloric Acid results in decreased expression of NOS3 protein |
CTD |
PMID:12771618 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
|
|
G |
Nox1 |
NADPH oxidase 1 |
affects response to substance |
ISO |
NOX1 protein affects the susceptibility to Hydrochloric Acid |
CTD |
PMID:21339339 |
|
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO |
Hydrochloric Acid results in increased expression of NQO1 mRNA NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of NQO1 mRNA] |
CTD |
PMID:29618784 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of PCK1 protein |
CTD |
PMID:20719974 |
|
NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
|
|
G |
Pcna |
proliferating cell nuclear antigen |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of PCNA mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
|
|
G |
Pga5 |
pepsinogen A5 |
multiple interactions |
EXP |
[Hydrochloric Acid co-treated with PGA5 protein] results in increased expression of FOS protein |
CTD |
PMID:12928072 |
|
NCBI chr 1:207,317,021...207,327,156
Ensembl chr 1:207,317,021...207,327,156
|
|
G |
Pkd2 |
polycystin 2, transient receptor potential cation channel |
multiple interactions |
ISO |
Hydrochloric Acid results in decreased activity of [PKD2 protein binds to PKD2 protein] |
CTD |
PMID:19193631 |
|
NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825
|
|
G |
Plpp3 |
phospholipid phosphatase 3 |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of PLPP3 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205
|
|
G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
decreases response to substance multiple interactions |
ISO |
PTGS1 results in decreased susceptibility to Hydrochloric Acid PTGS1 results in decreased susceptibility to [Hydrochloric Acid co-treated with Aspirin] |
CTD |
PMID:15236176 |
|
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO EXP |
[[Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [Hydrochloric Acid co-treated with Piroxicam] results in increased expression of PTGS2 mRNA Hydrochloric Acid results in increased expression of PTGS2 mRNA; Hydrochloric Acid results in increased expression of PTGS2 protein |
CTD |
PMID:9726391 PMID:12853844 PMID:15236176 PMID:15309881 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Pth |
parathyroid hormone |
decreases secretion |
ISO |
PTH protein results in decreased secretion of Hydrochloric Acid |
CTD |
PMID:20380354 |
|
NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
|
|
G |
Pycard |
PYD and CARD domain containing |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of PYCARD protein |
CTD |
PMID:31900028 |
|
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
|
|
G |
Rassf1 |
Ras association domain family member 1 |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of RASSF1 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases phosphorylation |
ISO |
MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased phosphorylation of RELA protein] |
CTD |
PMID:31900028 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Rhbg |
Rh family B glycoprotein |
multiple interactions increases expression |
ISO |
Hydrochloric Acid promotes the reaction [RHBG protein mutant form results in decreased expression of GLUL protein]; RHBG protein affects the reaction [Hydrochloric Acid results in increased export of Ammonia] Hydrochloric Acid results in increased expression of RHBG protein |
CTD |
PMID:20719974 |
|
NCBI chr 2:173,704,852...173,717,380
Ensembl chr 2:173,704,562...173,717,321
|
|
G |
Rhcg |
Rh family, C glycoprotein |
increases expression multiple interactions affects response to substance |
ISO EXP |
Hydrochloric Acid results in increased expression of RHCG protein RHCG protein affects the reaction [Hydrochloric Acid results in increased secretion of Ammonia] RHCG protein affects the susceptibility to Hydrochloric Acid [Hydrochloric Acid results in increased expression of RHCG protein] which results in increased secretion of Ammonia |
CTD |
PMID:16144966 PMID:19321595 PMID:20462967 |
|
NCBI chr 1:133,531,704...133,555,902
Ensembl chr 1:133,531,716...133,555,876
|
|
G |
Rrad |
RRAD, Ras related glycolysis inhibitor and calcium channel regulator |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of RRAD mRNA |
CTD |
PMID:15046208 |
|
NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
|
|
G |
Rreb1 |
ras responsive element binding protein 1 |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of RREB1 mRNA |
CTD |
PMID:15046208 |
|
NCBI chr17:26,876,687...27,002,554
Ensembl chr17:26,876,697...27,002,615
|
|
G |
Runx2 |
RUNX family transcription factor 2 |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of RUNX2 mRNA; Hydrochloric Acid results in increased expression of RUNX2 protein |
CTD |
PMID:17183249 |
|
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
|
|
G |
Scgb1a1 |
secretoglobin family 1A member 1 |
increases expression multiple interactions |
EXP |
Hydrochloric Acid results in increased expression of SCGB1A1 protein Quercetin inhibits the reaction [Hydrochloric Acid results in increased expression of SCGB1A1 protein] |
CTD |
PMID:24122261 |
|
NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610
|
|
G |
Serpine1 |
serpin family E member 1 |
affects response to substance |
ISO |
SERPINE1 protein affects the susceptibility to Hydrochloric Acid |
CTD |
PMID:19060228 |
|
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
|
|
G |
Sftpd |
surfactant protein D |
decreases expression increases expression multiple interactions |
EXP |
Hydrochloric Acid results in decreased expression of SFTPD protein Hydrochloric Acid results in increased expression of SFTPD protein S-methylisothiopseudouronium inhibits the reaction [Hydrochloric Acid results in decreased expression of SFTPD protein] |
CTD |
PMID:11880309 PMID:18573544 |
|
NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
|
|
G |
Slc38a1 |
solute carrier family 38, member 1 |
multiple interactions |
ISO |
[NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC38A1 mRNA |
CTD |
PMID:29618784 |
|
NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:127,738,226...127,802,218
|
|
G |
Slc38a3 |
solute carrier family 38, member 3 |
multiple interactions increases expression |
ISO |
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA]; NFE2L2 protein promotes the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA] |
CTD |
PMID:29618784 |
|
NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988
|
|
G |
Slc38a4 |
solute carrier family 38, member 4 |
decreases expression multiple interactions |
ISO |
Hydrochloric Acid results in decreased expression of SLC38A4 mRNA NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC38A4 mRNA] |
CTD |
PMID:29618784 |
|
NCBI chr 7:128,142,866...128,203,000
Ensembl chr 7:128,144,807...128,202,995
|
|
G |
Slc38a7 |
solute carrier family 38, member 7 |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of SLC38A7 mRNA |
CTD |
PMID:29618784 |
|
NCBI chr19:9,209,203...9,225,472
Ensembl chr19:9,209,257...9,225,454
|
|
G |
Slc3a2 |
solute carrier family 3 member 2 |
multiple interactions decreases expression |
ISO |
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC3A2 mRNA] |
CTD |
PMID:29618784 |
|
NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
|
|
G |
Slc6a19 |
solute carrier family 6 member 19 |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of SLC6A19 mRNA |
CTD |
PMID:29618784 |
|
NCBI chr 1:29,586,191...29,604,964
Ensembl chr 1:29,586,195...29,604,962
|
|
G |
Slc7a7 |
solute carrier family 7 member 7 |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of SLC7A7 mRNA |
CTD |
PMID:29618784 |
|
NCBI chr15:27,822,088...27,873,121
Ensembl chr15:27,822,091...27,865,648
|
|
G |
Slc7a9 |
solute carrier family 7 member 9 |
decreases expression multiple interactions |
ISO |
Hydrochloric Acid results in decreased expression of SLC7A9 mRNA NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC7A9 mRNA] |
CTD |
PMID:29618784 |
|
NCBI chr 1:88,109,517...88,132,653
Ensembl chr 1:88,110,644...88,132,641
|
|
G |
Slc9a4 |
solute carrier family 9 member A4 |
increases expression multiple interactions increases activity |
ISO EXP |
Hydrochloric Acid results in increased expression of SLC9A4 mRNA [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC9A4 mRNA; SLC9A4 protein affects the reaction [Hydrochloric Acid results in increased secretion of Ammonia] Hydrochloric Acid results in increased activity of SLC9A4 protein |
CTD |
PMID:20484819 PMID:29618784 |
|
NCBI chr 9:42,825,334...42,879,729
Ensembl chr 9:42,825,064...42,879,422
|
|
G |
Sod2 |
superoxide dismutase 2 |
decreases activity multiple interactions |
ISO |
Hydrochloric Acid results in decreased activity of SOD2 protein MitoTEMPO inhibits the reaction [Hydrochloric Acid results in decreased activity of SOD2 protein] |
CTD |
PMID:31900028 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Sp7 |
Sp7 transcription factor |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of SP7 mRNA; Hydrochloric Acid results in decreased expression of SP7 protein |
CTD |
PMID:17183249 |
|
NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
|
|
G |
Sst |
somatostatin |
increases expression |
EXP |
Hydrochloric Acid results in increased expression of SST protein |
CTD |
PMID:9530148 |
|
NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
|
|
G |
Sstr2 |
somatostatin receptor 2 |
affects response to substance |
ISO |
SSTR2 protein affects the susceptibility to Hydrochloric Acid |
CTD |
PMID:17363388 |
|
NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351
|
|
G |
Tac1 |
tachykinin, precursor 1 |
multiple interactions increases secretion |
EXP |
Botulinum Toxins, Type A inhibits the reaction [Hydrochloric Acid results in increased secretion of TAC1 protein] |
CTD |
PMID:18184328 |
|
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
|
|
G |
Tacr1 |
tachykinin receptor 1 |
affects response to substance |
EXP |
TACR1 protein affects the susceptibility to Hydrochloric Acid |
CTD |
PMID:11730984 |
|
NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
|
|
G |
Tacr3 |
tachykinin receptor 3 |
affects response to substance |
EXP |
TACR3 protein affects the susceptibility to Hydrochloric Acid |
CTD |
PMID:11730984 |
|
NCBI chr 2:223,266,536...223,363,791
Ensembl chr 2:223,266,536...223,363,791
|
|
G |
Tff2 |
trefoil factor 2 |
multiple interactions |
EXP |
[Aspirin co-treated with Hydrochloric Acid] results in increased expression of TFF2 mRNA |
CTD |
PMID:9726391 |
|
NCBI chr20:9,215,750...9,219,619
Ensembl chr20:9,215,761...9,219,619
|
|
G |
Tgfa |
transforming growth factor alpha |
multiple interactions increases expression |
EXP |
[Aspirin co-treated with Hydrochloric Acid] results in increased expression of TGFA mRNA; Celecoxib promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein]; Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein]; Piroxicam promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein] |
CTD |
PMID:9726391 PMID:15309881 |
|
NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
EXP ISO |
7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane inhibits the reaction [Hydrochloric Acid results in increased expression of TNF protein]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of TNF mRNA]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of TNF protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of TNF mRNA] Hydrochloric Acid results in increased expression of TNF mRNA; Hydrochloric Acid results in increased expression of TNF protein [Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein; boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein]; MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased expression of TNF mRNA]; MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased expression of TNF protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein] |
CTD |
PMID:15044056 PMID:15607125 PMID:16129981 PMID:25478868 PMID:31900028 PMID:32531310 More...
|
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
affects response to substance increases activity |
ISO EXP |
TRPV1 protein affects the susceptibility to Hydrochloric Acid Hydrochloric Acid results in increased activity of TRPV1 protein |
CTD |
PMID:15125461 PMID:15331673 PMID:17627983 PMID:18331834 PMID:19483072 |
|
NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
|
|
G |
Vegfc |
vascular endothelial growth factor C |
increases expression |
ISO |
Hydrochloric Acid results in increased expression of VEGFC mRNA |
CTD |
PMID:15046208 |
|
NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848
|
|
G |
Vgf |
VGF nerve growth factor inducible |
decreases expression |
ISO |
Hydrochloric Acid results in decreased expression of VGF mRNA |
CTD |
PMID:15046208 |
|
NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
|
|