Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydrogen chloride
go back to main search page
Accession:CHEBI:17883 term browser browse the term
Definition:A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.
Synonyms:exact_synonym: chlorane;   chloridohydrogen
 related_synonym: Chlorwasserstoff;   Formula=ClH;   Formula=HCl;   HCl;   Hydrochloride;   Hydrogenchlorid;   InChI=1S/ClH/h1H;   InChIKey=VEXZGXHMUGYJMC-UHFFFAOYSA-N;   SMILES=Cl[H];   Wasserstoffchlorid;   chlorure d'hydrogene;   cloruro de hidrogeno;   hydrochloric acid
 alt_id: CHEBI:13364;   CHEBI:24635;   CHEBI:5590
 xref: CAS:7647-01-0;   Drug_Central:4568;   Gmelin:322;   HMDB:HMDB0002306;   KEGG:C01327;   KEGG:D02057
 xref_mesh: MESH:D006851
 xref: MetaCyc:HCL;   PMID:15823700;   PMID:17492841;   PMID:22804993;   Reaxys:1098214;   Wikipedia:HCl;   Wikipedia:Hydrochloric_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:17996;   is_conjugate_base_of CHEBI:50315


show annotations for term's descendants           Sort by:
 
hydrogen chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
increases expression
EXP 7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane inhibits the reaction [Hydrochloric Acid results in increased expression of ALB protein]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of ALB protein] CTD PMID:15044056 PMID:15607125 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aqp4 aquaporin 4 increases expression EXP Hydrochloric Acid results in increased expression of AQP4 protein CTD PMID:18406487 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Areg amphiregulin decreases expression ISO Hydrochloric Acid results in decreased expression of AREG mRNA CTD PMID:15046208 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Bag3 BAG cochaperone 3 increases expression ISO Hydrochloric Acid results in increased expression of BAG3 mRNA CTD PMID:15046208 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO Hydrochloric Acid results in increased expression of BGLAP CTD PMID:17183249 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of CAR3 mRNA CTD PMID:29618784 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Calca calcitonin-related polypeptide alpha affects response to substance EXP CALCA protein affects the susceptibility to Hydrochloric Acid CTD PMID:19483072 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp3 caspase 3 decreases expression ISO Hydrochloric Acid results in decreased expression of CASP3 protein modified form CTD PMID:15046208 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 decreases expression ISO Hydrochloric Acid results in decreased expression of CASP9 mRNA CTD PMID:15046208 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP
ISO
CAT protein inhibits the reaction [Hydrochloric Acid results in increased susceptibility to Indomethacin]
[Ethanol co-treated with Hydrochloric Acid] results in increased activity of CAT protein; boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of CAT protein]
CTD PMID:1887894 PMID:32531310 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
EXP pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL2 protein]
Hydrochloric Acid results in increased expression of CCL2 mRNA; Hydrochloric Acid results in increased expression of CCL2 protein
CTD PMID:16129981 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression
multiple interactions
EXP Hydrochloric Acid results in increased expression of CCL4 mRNA; Hydrochloric Acid results in increased expression of CCL4 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL4 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL4 protein]
CTD PMID:16129981 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccna1 cyclin A1 increases expression ISO Hydrochloric Acid results in increased expression of CCNA1 mRNA CTD PMID:15046208 NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Hydrochloric Acid results in increased expression of CCND1 mRNA CTD PMID:15046208 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Hydrochloric Acid results in increased expression of CCNE1 mRNA CTD PMID:15046208 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 increases expression ISO Hydrochloric Acid results in increased expression of CCNE2 mRNA CTD PMID:15046208 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO Hydrochloric Acid inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Hydrochloric Acid inhibits the reaction [imidazolidinyl urea results in increased expression of CD86 protein] CTD PMID:29743441 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects localization ISO Hydrochloric Acid affects the localization of CDKN1B protein CTD PMID:20818264 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 decreases expression EXP Hydrochloric Acid results in decreased expression of CHRM3 protein CTD PMID:20719367 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
increases expression
EXP JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL1 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL1 mRNA]
Hydrochloric Acid results in increased expression of CXCL1 mRNA; Hydrochloric Acid results in increased expression of CXCL1 protein
CTD PMID:15044056 PMID:16129981 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions
EXP Hydrochloric Acid results in increased expression of CXCL2 mRNA; Hydrochloric Acid results in increased expression of CXCL2 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL2 protein]
CTD PMID:16129981 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression
multiple interactions
ISO Hydrochloric Acid results in increased expression of CYP2A5 mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of CYP2A5 mRNA]
CTD PMID:29618784 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Dpys dihydropyrimidinase increases expression
multiple interactions
ISO Hydrochloric Acid results in increased expression of DPYS mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of DPYS mRNA]
CTD PMID:29618784 NCBI chr 7:78,769,918...78,847,941
Ensembl chr 7:78,769,807...78,847,974
JBrowse link
G Dusp2 dual specificity phosphatase 2 decreases expression ISO Hydrochloric Acid results in decreased expression of DUSP2 mRNA CTD PMID:15046208 NCBI chr 3:119,776,925...119,779,110
Ensembl chr 3:119,776,925...119,779,099
JBrowse link
G Dusp8 dual specificity phosphatase 8 decreases expression ISO Hydrochloric Acid results in decreased expression of DUSP8 mRNA CTD PMID:15046208 NCBI chr 1:215,030,429...215,043,111
Ensembl chr 1:215,030,429...215,033,460
JBrowse link
G E2f5 E2F transcription factor 5 increases expression ISO Hydrochloric Acid results in increased expression of E2F5 mRNA CTD PMID:15046208 NCBI chr 2:88,350,764...88,366,913
Ensembl chr 2:88,351,361...88,366,115
JBrowse link
G Edn1 endothelin 1 increases expression EXP Hydrochloric Acid results in increased expression of EDN1 protein CTD PMID:19262391 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Efna4 ephrin A4 increases expression ISO Hydrochloric Acid results in increased expression of EFNA4 mRNA CTD PMID:15046208 NCBI chr 2:188,655,920...188,660,179
Ensembl chr 2:188,655,912...188,660,179
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases expression
EXP Celecoxib promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein]; Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein]; Piroxicam promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein] CTD PMID:15309881 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Hydrochloric Acid results in increased expression of EMP1 mRNA CTD PMID:15046208 NCBI chr 4:169,161,076...169,181,967
Ensembl chr 4:169,147,243...169,181,966
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO Hydrochloric Acid results in decreased expression of FGF2 mRNA CTD PMID:15046208 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 increases expression ISO Hydrochloric Acid results in increased expression of FGFR3 mRNA CTD PMID:15046208 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP [Hydrochloric Acid co-treated with PGA5 protein] results in increased expression of FOS protein; Capsaicin inhibits the reaction [Hydrochloric Acid results in increased expression of FOS protein]; Hexamethonium inhibits the reaction [Hydrochloric Acid results in increased expression of FOS protein]; SB 222200 affects the reaction [Hydrochloric Acid results in increased expression of FOS mRNA]; vofopitant affects the reaction [Hydrochloric Acid results in increased expression of FOS mRNA]
Hydrochloric Acid results in increased expression of FOS mRNA; Hydrochloric Acid results in increased expression of FOS protein
CTD PMID:11730984 PMID:12588467 PMID:12928072 PMID:14750966 PMID:16162281 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit decreases expression ISO Hydrochloric Acid results in decreased expression of FOSL2 mRNA CTD PMID:15046208 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression ISO Hydrochloric Acid results in decreased expression of GADD45A mRNA CTD PMID:15046208 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLC mRNA] CTD PMID:29618784 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLM mRNA] CTD PMID:29618784 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gls glutaminase multiple interactions
increases expression
ISO [Hydrochloric Acid results in decreased expression of GLS protein] which results in increased secretion of Ammonia
Hydrochloric Acid results in increased expression of GLS mRNA; Hydrochloric Acid results in increased expression of GLS protein
CTD PMID:20719974 PMID:29618784 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
JBrowse link
G Glul glutamate-ammonia ligase multiple interactions ISO Hydrochloric Acid promotes the reaction [RHBG protein mutant form results in decreased expression of GLUL protein] CTD PMID:20719974 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GSTA3 mRNA] CTD PMID:29618784 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GSTM1 mRNA] CTD PMID:29618784 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gtpbp2 GTP binding protein 2 decreases expression ISO Hydrochloric Acid results in decreased expression of GTPBP2 mRNA CTD PMID:15046208 NCBI chr 9:17,198,957...17,208,456
Ensembl chr 9:17,198,957...17,209,220
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of HAVCR1 mRNA CTD PMID:29618784 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP beraprost inhibits the reaction [Hydrochloric Acid results in increased expression of HMOX1 protein]; Capsaicin promotes the reaction [Hydrochloric Acid results in increased expression of HMOX1 protein] CTD PMID:18617559 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsf1 heat shock transcription factor 1 affects response to substance ISO HSF1 protein affects the susceptibility to Hydrochloric Acid CTD PMID:17189318 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A affects response to substance EXP HSPA1A protein affects the susceptibility to Hydrochloric Acid CTD PMID:16945336 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B affects response to substance EXP HSPA1B protein affects the susceptibility to Hydrochloric Acid CTD PMID:15338365 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions
EXP
ISO
Hydrochloric Acid results in increased expression of ICAM1 mRNA
Hydrochloric Acid inhibits the reaction [Dinitrochlorobenzene results in increased expression of ICAM1 protein]; Hydrochloric Acid inhibits the reaction [imidazolidinyl urea results in increased expression of ICAM1 protein]
pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of ICAM1 mRNA]
CTD PMID:16129981 PMID:29743441 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Hydrochloric Acid results in increased expression of ID2 mRNA CTD PMID:15046208 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP
ISO
[Celecoxib co-treated with Hydrochloric Acid] results in increased expression of IL1B protein
[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein]
Hydrochloric Acid results in increased expression of IL1B protein
CTD PMID:15309881 PMID:25478868 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il5 interleukin 5 increases expression EXP Hydrochloric Acid results in increased expression of IL5 protein CTD PMID:19951613 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP
ISO
7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 protein]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 mRNA]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 protein]
[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL6 protein; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL6 protein]
Hydrochloric Acid results in increased expression of IL6 mRNA; Hydrochloric Acid results in increased expression of IL6 protein
CTD PMID:11850527 PMID:12771618 PMID:15044056 PMID:15607125 PMID:19951613 PMID:25478868 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 decreases activity
decreases expression
EXP Hydrochloric Acid results in decreased activity of KCNA4 protein
Hydrochloric Acid results in decreased expression of KCNA4 protein
CTD PMID:19279288 NCBI chr 3:98,293,295...98,300,763
Ensembl chr 3:98,297,554...98,300,680
JBrowse link
G Kdm5b lysine demethylase 5B decreases expression ISO Hydrochloric Acid results in decreased expression of KDM5B mRNA CTD PMID:15046208 NCBI chr13:51,384,371...51,455,392
Ensembl chr13:51,384,389...51,455,357
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Hydrochloric Acid results in decreased expression of MCL1 mRNA CTD PMID:15046208 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression ISO Hydrochloric Acid results in increased expression of MCM4 mRNA CTD PMID:15046208 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mif macrophage migration inhibitory factor increases expression EXP Hydrochloric Acid results in increased expression of MIF mRNA; Hydrochloric Acid results in increased expression of MIF protein CTD PMID:12853844 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression EXP Hydrochloric Acid results in increased expression of MMP1 protein CTD PMID:11850527 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions
EXP
ISO
Hydrochloric Acid results in increased activity of MPO protein
[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein; [Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein; [lupeol binds to stearic acid] inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein]; baicalein inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein]; Omeprazole inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]
CTD PMID:11574821 PMID:15309881 PMID:25478868 PMID:27780710 PMID:32006539 PMID:32531310 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases localization
multiple interactions
increases response to substance
EXP
ISO
Hydrochloric Acid results in increased localization of NFE2L2 protein
[NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of CAR3 mRNA; [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of HAVCR1 mRNA; [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC38A1 mRNA; [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC9A4 mRNA; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC38A4 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC3A2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC7A9 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of CYP2A5 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of DPYS mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLM mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GSTA3 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GSTM1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA]; NFE2L2 protein promotes the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA]
CTD PMID:18617559 PMID:29618784 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
affects response to substance
EXP
ISO
pimagedine inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]; S-methylisothiopseudouronium inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]
NOS2 protein affects the susceptibility to Hydrochloric Acid
CTD PMID:11574821 PMID:12646421 PMID:12771618 PMID:18573544 PMID:24122261 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression EXP Hydrochloric Acid results in decreased expression of NOS3 protein CTD PMID:12771618 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox1 NADPH oxidase 1 affects response to substance ISO NOX1 protein affects the susceptibility to Hydrochloric Acid CTD PMID:21339339 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO Hydrochloric Acid results in increased expression of NQO1 mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of NQO1 mRNA]
CTD PMID:29618784 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Hydrochloric Acid results in increased expression of PCK1 protein CTD PMID:20719974 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Hydrochloric Acid results in increased expression of PCNA mRNA CTD PMID:15046208 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pga5 pepsinogen A5 multiple interactions EXP [Hydrochloric Acid co-treated with PGA5 protein] results in increased expression of FOS protein CTD PMID:12928072 NCBI chr 1:226,722,198...226,732,736
Ensembl chr 1:226,722,198...226,732,736
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel multiple interactions ISO Hydrochloric Acid results in decreased activity of [PKD2 protein binds to PKD2 protein] CTD PMID:19193631 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257
JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases expression ISO Hydrochloric Acid results in decreased expression of PLPP3 mRNA CTD PMID:15046208 NCBI chr 5:124,690,214...124,765,499
Ensembl chr 5:124,690,214...124,765,498
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases response to substance
multiple interactions
ISO PTGS1 results in decreased susceptibility to Hydrochloric Acid
PTGS1 results in decreased susceptibility to [Hydrochloric Acid co-treated with Aspirin]
CTD PMID:15236176 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO
EXP
[[Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein
Hydrochloric Acid results in increased expression of PTGS2 mRNA; Hydrochloric Acid results in increased expression of PTGS2 protein
[Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [Hydrochloric Acid co-treated with Piroxicam] results in increased expression of PTGS2 mRNA
CTD PMID:9726391 PMID:12853844 PMID:15236176 PMID:15309881 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pth parathyroid hormone decreases secretion ISO PTH protein results in decreased secretion of Hydrochloric Acid CTD PMID:20380354 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Rassf1 Ras association domain family member 1 decreases expression ISO Hydrochloric Acid results in decreased expression of RASSF1 mRNA CTD PMID:15046208 NCBI chr 8:116,307,149...116,318,289
Ensembl chr 8:116,307,141...116,318,289
JBrowse link
G Rhbg Rh family B glycoprotein multiple interactions
increases expression
ISO Hydrochloric Acid promotes the reaction [RHBG protein mutant form results in decreased expression of GLUL protein]; RHBG protein affects the reaction [Hydrochloric Acid results in increased export of Ammonia]
Hydrochloric Acid results in increased expression of RHBG protein
CTD PMID:20719974 NCBI chr 2:187,610,081...187,622,408
Ensembl chr 2:187,610,087...187,622,373
JBrowse link
G Rhcg Rh family, C glycoprotein increases expression
multiple interactions
affects response to substance
ISO
EXP
Hydrochloric Acid results in increased expression of RHCG protein
[Hydrochloric Acid results in increased expression of RHCG protein] which results in increased secretion of Ammonia
RHCG protein affects the susceptibility to Hydrochloric Acid
RHCG protein affects the reaction [Hydrochloric Acid results in increased secretion of Ammonia]
CTD PMID:16144966 PMID:19321595 PMID:20462967 NCBI chr 1:141,325,854...141,349,881
Ensembl chr 1:141,325,856...141,349,881
JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator increases expression ISO Hydrochloric Acid results in increased expression of RRAD mRNA CTD PMID:15046208 NCBI chr19:561,696...564,929
Ensembl chr19:561,727...564,930
JBrowse link
G Rreb1 ras responsive element binding protein 1 decreases expression ISO Hydrochloric Acid results in decreased expression of RREB1 mRNA CTD PMID:15046208 NCBI chr17:27,539,137...27,718,878
Ensembl chr17:27,539,133...27,665,266
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO Hydrochloric Acid results in increased expression of RUNX2 mRNA; Hydrochloric Acid results in increased expression of RUNX2 protein CTD PMID:17183249 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 increases expression
multiple interactions
EXP Hydrochloric Acid results in increased expression of SCGB1A1 protein
Quercetin inhibits the reaction [Hydrochloric Acid results in increased expression of SCGB1A1 protein]
CTD PMID:24122261 NCBI chr 1:225,279,698...225,283,246
Ensembl chr 1:225,279,676...225,283,326
JBrowse link
G Serpine1 serpin family E member 1 affects response to substance ISO SERPINE1 protein affects the susceptibility to Hydrochloric Acid CTD PMID:19060228 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sftpd surfactant protein D decreases expression
multiple interactions
increases expression
EXP Hydrochloric Acid results in decreased expression of SFTPD protein
S-methylisothiopseudouronium inhibits the reaction [Hydrochloric Acid results in decreased expression of SFTPD protein]
Hydrochloric Acid results in increased expression of SFTPD protein
CTD PMID:11880309 PMID:18573544 NCBI chr16:18,753,535...18,766,100
Ensembl chr16:18,745,458...18,766,174
JBrowse link
G Slc38a1 solute carrier family 38, member 1 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC38A1 mRNA CTD PMID:29618784 NCBI chr 7:137,970,555...138,040,098
Ensembl chr 7:137,975,549...138,039,984
JBrowse link
G Slc38a3 solute carrier family 38, member 3 multiple interactions
increases expression
ISO NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA]; NFE2L2 protein promotes the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA] CTD PMID:29618784 NCBI chr 8:116,406,258...116,423,752
Ensembl chr 8:116,406,241...116,422,366
JBrowse link
G Slc38a4 solute carrier family 38, member 4 decreases expression
multiple interactions
ISO Hydrochloric Acid results in decreased expression of SLC38A4 mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC38A4 mRNA]
CTD PMID:29618784 NCBI chr 7:138,459,576...138,512,952
Ensembl chr 7:138,459,504...138,512,952
JBrowse link
G Slc38a7 solute carrier family 38, member 7 decreases expression ISO Hydrochloric Acid results in decreased expression of SLC38A7 mRNA CTD PMID:29618784 NCBI chr19:9,622,594...9,638,221
Ensembl chr19:9,622,611...9,638,222
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions
decreases expression
ISO NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC3A2 mRNA] CTD PMID:29618784 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc6a19 solute carrier family 6 member 19 decreases expression ISO Hydrochloric Acid results in decreased expression of SLC6A19 mRNA CTD PMID:29618784 NCBI chr 1:32,199,869...32,218,628
Ensembl chr 1:32,199,810...32,220,045
JBrowse link
G Slc7a7 solute carrier family 7 member 7 decreases expression ISO Hydrochloric Acid results in decreased expression of SLC7A7 mRNA CTD PMID:29618784 NCBI chr15:33,013,346...33,059,733
Ensembl chr15:33,013,504...33,051,129
JBrowse link
G Slc7a9 solute carrier family 7 member 9 decreases expression
multiple interactions
ISO Hydrochloric Acid results in decreased expression of SLC7A9 mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC7A9 mRNA]
CTD PMID:29618784 NCBI chr 1:91,709,034...91,738,492
Ensembl chr 1:91,716,383...91,738,494
JBrowse link
G Slc9a4 solute carrier family 9 member A4 increases expression
increases activity
multiple interactions
ISO
EXP
Hydrochloric Acid results in increased expression of SLC9A4 mRNA
Hydrochloric Acid results in increased activity of SLC9A4 protein
[NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC9A4 mRNA; SLC9A4 protein affects the reaction [Hydrochloric Acid results in increased secretion of Ammonia]
CTD PMID:20484819 PMID:29618784 NCBI chr 9:47,281,821...47,334,755
Ensembl chr 9:47,281,961...47,328,839
JBrowse link
G Sp7 Sp7 transcription factor decreases expression ISO Hydrochloric Acid results in decreased expression of SP7 mRNA; Hydrochloric Acid results in decreased expression of SP7 protein CTD PMID:17183249 NCBI chr 7:143,957,316...143,967,488
Ensembl chr 7:143,958,858...143,967,484
JBrowse link
G Sst somatostatin increases expression EXP Hydrochloric Acid results in increased expression of SST protein CTD PMID:9530148 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444
JBrowse link
G Sstr2 somatostatin receptor 2 affects response to substance ISO SSTR2 protein affects the susceptibility to Hydrochloric Acid CTD PMID:17363388 NCBI chr10:102,136,283...102,143,449
Ensembl chr10:102,136,283...102,143,434
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions
increases secretion
EXP Botulinum Toxins, Type A inhibits the reaction [Hydrochloric Acid results in increased secretion of TAC1 protein] CTD PMID:18184328 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tacr1 tachykinin receptor 1 affects response to substance EXP TACR1 protein affects the susceptibility to Hydrochloric Acid CTD PMID:11730984 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Tacr3 tachykinin receptor 3 affects response to substance EXP TACR3 protein affects the susceptibility to Hydrochloric Acid CTD PMID:11730984 NCBI chr 2:240,021,152...240,118,971
Ensembl chr 2:240,021,152...240,118,971
JBrowse link
G Tff2 trefoil factor 2 multiple interactions EXP [Aspirin co-treated with Hydrochloric Acid] results in increased expression of TFF2 mRNA CTD PMID:9726391 NCBI chr20:9,872,669...9,876,008
Ensembl chr20:9,872,680...9,876,008
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions
increases expression
EXP [Aspirin co-treated with Hydrochloric Acid] results in increased expression of TGFA mRNA; Celecoxib promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein]; Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein]; Piroxicam promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein] CTD PMID:9726391 PMID:15309881 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP
ISO
7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane inhibits the reaction [Hydrochloric Acid results in increased expression of TNF protein]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of TNF mRNA]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of TNF protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of TNF mRNA]
[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein; boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein]
Hydrochloric Acid results in increased expression of TNF mRNA; Hydrochloric Acid results in increased expression of TNF protein
CTD PMID:15044056 PMID:15607125 PMID:16129981 PMID:25478868 PMID:32531310 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects response to substance
increases activity
ISO
EXP
TRPV1 protein affects the susceptibility to Hydrochloric Acid
Hydrochloric Acid results in increased activity of TRPV1 protein
CTD PMID:15125461 PMID:15331673 PMID:17627983 PMID:18331834 PMID:19483072 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Vegfc vascular endothelial growth factor C increases expression ISO Hydrochloric Acid results in increased expression of VEGFC mRNA CTD PMID:15046208 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
G Vgf VGF nerve growth factor inducible decreases expression ISO Hydrochloric Acid results in decreased expression of VGF mRNA CTD PMID:15046208 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    chemical entity 19767
      molecular entity 19766
        main group molecular entity 19657
          gas molecular entity 17757
            hydrogen chloride 102
              chloro group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    main group molecular entity 19657
                      s-block molecular entity 19421
                        hydrogen molecular entity 19414
                          hydrides 18754
                            mononuclear parent hydride 17412
                              hydrogen chloride 102
                                chloro group 0
paths to the root