nickel sulfate - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	nickel sulfate	go back to main search page
Accession:	CHEBI:53001	browse the term
Definition:	A metal sulfate having nickel(2+) as the metal ion.
Synonyms:	exact_synonym:	nickel(2+) sulfate
	related_synonym:	Formula=NiO4S; InChI=1S/Ni.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2; InChIKey=LGQLOGILCSXPEA-UHFFFAOYSA-L; NiSO4; Nickel sulfate(1:1); Nickel sulphate; Nickel(II) sulfate (1:1); SMILES=[Ni++].[O-]S([O-])(=O)=O; nickel(II) sulfate
	xref:	CAS:7786-81-4; Gmelin:8299
	xref_mesh:	MESH:C029938
	xref:	PMID:10444249; PMID:10444250; PMID:10469300; PMID:10975816; PMID:11207315; PMID:11851891; PMID:14634084; PMID:1694310; PMID:18837732; PMID:2026136; PMID:21616561; PMID:2415590; PMID:2477914; PMID:25042713; PMID:25097477; PMID:7615984; PMID:7687268; PMID:8566016; PMID:8891004; PMID:8991630; Reaxys:11329960; Wikipedia:Nickel(II)_sulfate

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Genes (1592)

nickel sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 1810030O07 gene

decreases expression

nickel sulfate results in decreased expression of CXORF38 mRNA

NCBI chr X:12,521,118...12,540,175
Ensembl chr X:12,521,118...12,539,907

G

RIKEN cDNA 2200002D01 gene

decreases expression

nickel sulfate results in decreased expression of C19ORF33 mRNA

NCBI chr 7:28,946,946...28,947,892
Ensembl chr 7:28,945,986...28,947,891

G

RIKEN cDNA 2310022B05 gene

increases expression

nickel sulfate results in increased expression of C1ORF198 mRNA

NCBI chr 8:125,362,495...125,390,108
Ensembl chr 8:125,362,495...125,390,108

G

RIKEN cDNA 4921504E06 gene

decreases expression

nickel sulfate results in decreased expression of C10ORF67 mRNA

NCBI chr 2:19,467,648...19,558,721
Ensembl chr 2:19,467,648...19,558,725

G

expressed sequence AA467197

increases expression

nickel sulfate results in increased expression of C15ORF48 mRNA

NCBI chr 2:122,479,807...122,482,996
Ensembl chr 2:122,478,906...122,483,111

G

aminoadipate-semialdehyde synthase

decreases expression

nickel sulfate results in decreased expression of AASS mRNA

NCBI chr 6:23,072,172...23,132,985
Ensembl chr 6:23,072,172...23,132,985

G

ATP-binding cassette, sub-family A member 5

increases expression

nickel sulfate results in increased expression of ABCA5 mRNA

NCBI chr11:110,160,195...110,228,542
Ensembl chr11:110,160,195...110,228,542

G

ATP-binding cassette, sub-family A member 6

decreases expression

nickel sulfate results in decreased expression of ABCA6 mRNA

PMID:16780908 PMID:17374397

NCBI chr11:110,065,464...110,142,811
Ensembl chr11:110,067,646...110,142,602

G

ATP-binding cassette, sub-family C member 1

increases expression

nickel sulfate results in increased expression of ABCC1 mRNA

NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601

G

ATP-binding cassette, sub-family C member 3

increases expression

nickel sulfate results in increased expression of ABCC3 mRNA

PMID:16314067 PMID:22714537

NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823

G

abhydrolase domain containing 10

decreases expression

nickel sulfate results in decreased expression of ABHD10 mRNA

NCBI chr16:45,550,088...45,563,355
Ensembl chr16:45,550,088...45,563,318

G

abhydrolase domain containing 12

decreases expression

nickel sulfate results in decreased expression of ABHD12 mRNA

NCBI chr 2:150,674,413...150,746,705
Ensembl chr 2:150,674,413...150,746,661

G

abhydrolase domain containing 17A

increases expression

nickel sulfate results in increased expression of ABHD17A mRNA

NCBI chr10:80,419,483...80,426,199
Ensembl chr10:80,419,488...80,426,175

G

ABI family member 3 binding protein

increases expression

nickel sulfate results in increased expression of ABI3BP mRNA

NCBI chr16:56,298,179...56,510,498
Ensembl chr16:56,298,241...56,510,498

G

actin-binding LIM protein 1

decreases expression

nickel sulfate results in decreased expression of ABLIM1 mRNA

NCBI chr19:57,021,165...57,303,776
Ensembl chr19:57,021,165...57,303,351

G

BRCA1 A complex subunit

decreases expression

nickel sulfate results in decreased expression of ABRAXAS1 mRNA

NCBI chr 5:100,952,668...100,968,816
Ensembl chr 5:100,953,058...100,968,831

G

acyl-Coenzyme A binding domain containing 7

decreases expression

nickel sulfate results in decreased expression of ACBD7 mRNA

NCBI chr 2:3,333,850...3,342,035
Ensembl chr 2:3,337,205...3,342,030

G

aconitase 1

decreases expression

nickel sulfate results in decreased expression of ACO1 mRNA

NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338

G

aconitase 2, mitochondrial

increases expression

nickel sulfate results in increased expression of ACO2 mRNA

NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334

G

acyl-CoA thioesterase 13

increases expression

nickel sulfate results in increased expression of ACOT13 mRNA

NCBI chr13:25,001,938...25,015,472
Ensembl chr13:25,001,931...25,015,523

G

acyl-CoA thioesterase 2

increases expression

nickel sulfate results in increased expression of ACOT2 mRNA

NCBI chr12:84,034,635...84,040,651
Ensembl chr12:84,034,635...84,040,647

G

acyl-CoA thioesterase 4

decreases expression

nickel sulfate results in decreased expression of ACOT4 mRNA

NCBI chr12:84,084,028...84,091,497
Ensembl chr12:84,085,153...84,095,375

G

acyl-Coenzyme A oxidase 2, branched chain

increases expression

nickel sulfate results in increased expression of ACOX2 mRNA

NCBI chr14:14,210,406...14,244,262
Ensembl chr14:14,210,420...14,244,262

G

acyl-CoA synthetase long-chain family member 5

decreases expression

nickel sulfate results in decreased expression of ACSL5 mRNA

NCBI chr19:55,240,298...55,285,060
Ensembl chr19:55,240,370...55,286,152

G

acyl-CoA synthetase short-chain family member 2

increases expression

nickel sulfate results in increased expression of ACSS2 mRNA

NCBI chr 2:155,359,963...155,404,663
Ensembl chr 2:155,359,868...155,427,644

G

actin alpha 1, skeletal muscle

increases expression

nickel sulfate results in increased expression of ACTA1 mRNA

NCBI chr 8:124,618,497...124,621,514
Ensembl chr 8:124,618,508...124,621,490

G

actin, alpha, cardiac muscle 1

decreases expression

nickel sulfate results in decreased expression of ACTC1 mRNA

NCBI chr 2:113,877,763...113,883,356
Ensembl chr 2:113,877,763...113,884,029

G

actin, gamma 2, smooth muscle, enteric

increases expression

nickel sulfate results in increased expression of ACTG2 mRNA

NCBI chr 6:83,489,891...83,513,233
Ensembl chr 6:83,489,887...83,513,247

G

activin A receptor, type 1

increases expression

nickel sulfate results in increased expression of ACVR1 mRNA

NCBI chr 2:58,336,450...58,456,840
Ensembl chr 2:58,278,656...58,457,169

G

activin A receptor, type 1B

increases expression

nickel sulfate results in increased expression of ACVR1B mRNA

NCBI chr15:101,071,953...101,111,565
Ensembl chr15:101,071,948...101,111,565

G

adenosine deaminase

increases expression

nickel sulfate results in increased expression of ADA mRNA

NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159

G

ADAM metallopeptidase domain 12

decreases expression

nickel sulfate results in decreased expression of ADAM12 mRNA

NCBI chr 7:133,484,928...133,826,859
Ensembl chr 7:133,484,928...133,833,875

G

ADAM metallopeptidase domain 19

decreases expression

nickel sulfate results in decreased expression of ADAM19 mRNA

NCBI chr11:45,945,329...46,038,174
Ensembl chr11:45,946,819...46,038,170

G

a disintegrin and metallopeptidase domain 32

decreases expression

nickel sulfate results in decreased expression of ADAM32 mRNA

NCBI chr 8:25,326,159...25,438,933
Ensembl chr 8:25,326,156...25,438,820

G

a disintegrin and metallopeptidase domain 8

increases expression

nickel sulfate results in increased expression of ADAM8 mRNA

NCBI chr 7:139,558,845...139,573,016
Ensembl chr 7:139,558,845...139,572,475

G

ADAM metallopeptidase with thrombospondin type 1 motif 12

decreases expression

nickel sulfate results in decreased expression of ADAMTS12 mRNA

NCBI chr15:11,064,781...11,349,321
Ensembl chr15:11,064,876...11,349,317

G

ADAM metallopeptidase with thrombospondin type 1 motif 3

decreases expression

nickel sulfate results in decreased expression of ADAMTS3 mRNA

NCBI chr 5:89,821,700...90,031,521
Ensembl chr 5:89,824,946...90,031,193

G

ADAMTS-like 1

decreases expression

nickel sulfate results in decreased expression of ADAMTSL1 mRNA

NCBI chr 4:85,432,242...86,346,627
Ensembl chr 4:85,432,409...86,346,622

G

ADAMTS-like 3

decreases expression

nickel sulfate results in decreased expression of ADAMTSL3 mRNA

NCBI chr 7:81,984,612...82,263,658
Ensembl chr 7:81,984,902...82,263,658

G

aarF domain containing kinase 2

increases expression

nickel sulfate results in increased expression of ADCK2 mRNA

NCBI chr 6:39,550,778...39,565,703
Ensembl chr 6:39,550,807...39,565,703

G

adenylate cyclase 7

decreases expression

nickel sulfate results in decreased expression of ADCY7 mRNA

NCBI chr 8:88,998,818...89,056,593
Ensembl chr 8:88,999,031...89,056,590

G

adducin 3

decreases expression

nickel sulfate results in decreased expression of ADD3 mRNA

NCBI chr19:53,128,874...53,235,518
Ensembl chr19:53,128,874...53,235,830

G

adhesion G protein-coupled receptor G1

increases expression

nickel sulfate results in increased expression of ADGRG1 mRNA

NCBI chr 8:95,701,321...95,740,836
Ensembl chr 8:95,701,379...95,740,845

G

adrenomedullin

increases expression
decreases expression

nickel sulfate results in increased expression of ADM mRNA
nickel sulfate results in decreased expression of ADM mRNA

PMID:18651567 PMID:22714537

NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027

G

adenosine A2a receptor

increases expression

nickel sulfate results in increased expression of ADORA2A mRNA

PMID:16780908 PMID:22714537

NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618

G

adenosine A2b receptor

increases expression

nickel sulfate results in increased expression of ADORA2B mRNA

NCBI chr11:62,139,810...62,157,278
Ensembl chr11:62,139,810...62,157,279

G

actin filament associated protein 1-like 2

decreases expression

nickel sulfate results in decreased expression of AFAP1L2 mRNA

NCBI chr19:56,900,786...57,017,021
Ensembl chr19:56,900,793...56,996,660

G

AF4/FMR2 family, member 3

increases expression

nickel sulfate results in increased expression of AFF3 mRNA

NCBI chr 1:38,212,936...38,704,036
Ensembl chr 1:38,216,407...38,704,036

G

ATP/GTP binding protein-like 5

increases expression

nickel sulfate results in increased expression of AGBL5 mRNA

NCBI chr 5:31,045,321...31,064,008
Ensembl chr 5:31,046,038...31,064,309

G

agmatinase

decreases expression

nickel sulfate results in decreased expression of AGMAT mRNA

NCBI chr 4:141,473,986...141,486,574
Ensembl chr 4:141,473,983...141,486,574

G

ATP/GTP binding protein 1

decreases expression

nickel sulfate results in decreased expression of AGTPBP1 mRNA

NCBI chr13:59,597,348...59,705,184
Ensembl chr13:59,593,556...59,733,041

G

S-adenosylhomocysteine hydrolase-like 1

affects expression

nickel sulfate affects the expression of AHCYL1 mRNA

NCBI chr 3:107,570,436...107,603,876
Ensembl chr 3:107,570,434...107,603,876

G

AT hook, DNA binding motif, containing 1

increases expression

nickel sulfate results in increased expression of AHDC1 mRNA

NCBI chr 4:132,738,797...132,805,421
Ensembl chr 4:132,738,571...132,805,421

G

AHNAK nucleoprotein 2

increases expression

nickel sulfate results in increased expression of AHNAK2 mRNA

NCBI chr12:112,738,631...112,766,278
Ensembl chr12:112,738,628...112,766,277

G

expressed sequence AI661453

decreases expression

nickel sulfate results in decreased expression of C6ORF132 mRNA

NCBI chr17:47,747,564...47,781,563
Ensembl chr17:47,747,540...47,781,563

G

A kinase anchor protein 11

decreases expression

nickel sulfate results in decreased expression of AKAP11 mRNA

NCBI chr14:78,729,686...78,774,306
Ensembl chr14:78,729,686...78,774,248

G

aldo-keto reductase family 1 member B

increases expression

nickel sulfate results in increased expression of AKR1B1 mRNA

NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413

G

aldo-keto reductase family 1, member B10

increases expression

nickel sulfate results in increased expression of AKR1B10 mRNA

NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885

G

aldo-keto reductase family 1, member C18

increases expression

nickel sulfate results in increased expression of AKR1C3 mRNA

NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653

G

aldo-keto reductase family 1, member E1

decreases expression

nickel sulfate results in decreased expression of AKR1E2 mRNA

NCBI chr13:4,641,122...4,659,163
Ensembl chr13:4,640,749...4,659,173

G

thymoma viral proto-oncogene 1

increases phosphorylation

nickel sulfate results in increased phosphorylation of AKT1 protein

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

activated leukocyte cell adhesion molecule

increases expression

nickel sulfate results in increased expression of ALCAM mRNA

NCBI chr16:52,069,359...52,273,444
Ensembl chr16:52,069,359...52,274,437

G

aldehyde dehydrogenase 1 family, member L2

decreases expression

nickel sulfate results in decreased expression of ALDH1L2 mRNA

NCBI chr10:83,320,386...83,370,008
Ensembl chr10:83,323,314...83,370,004

G

aldehyde dehydrogenase family 3, subfamily A2

increases expression

nickel sulfate results in increased expression of ALDH3A2 mRNA

NCBI chr11:61,114,240...61,158,267
Ensembl chr11:61,114,243...61,158,290

G

aldhehyde dehydrogenase family 5, subfamily A1

increases expression

nickel sulfate results in increased expression of ALDH5A1 mRNA

NCBI chr13:25,091,562...25,121,740
Ensembl chr13:25,091,562...25,121,644
Ensembl chr13:25,091,562...25,121,644

G

aldolase C, fructose-bisphosphate

increases expression

nickel sulfate results in increased expression of ALDOC mRNA

PMID:17382205 PMID:22714537

NCBI chr11:78,213,899...78,218,607
Ensembl chr11:78,213,794...78,218,607

G

ALG5 dolichyl-phosphate beta-glucosyltransferase

decreases expression

nickel sulfate results in decreased expression of ALG5 mRNA

NCBI chr 3:54,642,960...54,657,216
Ensembl chr 3:54,642,960...54,658,739

G

arachidonate 5-lipoxygenase activating protein

decreases expression

nickel sulfate results in decreased expression of ALOX5AP mRNA

NCBI chr 5:149,201,814...149,224,963
Ensembl chr 5:149,201,577...149,224,963

G

alpha-kinase 2

decreases expression

nickel sulfate results in decreased expression of ALPK2 mRNA

NCBI chr18:65,398,600...65,526,959
Ensembl chr18:65,398,600...65,527,137

G

Aly/REF export factor

increases expression

nickel sulfate results in increased expression of THOC4 mRNA

NCBI chr11:120,485,330...120,489,342
Ensembl chr11:120,482,947...120,489,191

G

adenosine monophosphate deaminase 3

affects expression

nickel sulfate affects the expression of AMPD3 mRNA

NCBI chr 7:110,367,291...110,411,612
Ensembl chr 7:110,367,413...110,411,612

G

angiopoietin-like 4

multiple interactions
increases expression

[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of ANGPTL4 mRNA
nickel sulfate results in increased expression of ANGPTL4 mRNA

PMID:16166746 PMID:17382205 PMID:18832182

NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804

G

progressive ankylosis

increases expression

nickel sulfate results in increased expression of ANKH mRNA

NCBI chr15:27,466,763...27,594,995
Ensembl chr15:27,466,763...27,594,995

G

ankyrin repeat domain 1

decreases expression

nickel sulfate results in decreased expression of ANKRD1 mRNA

NCBI chr19:36,089,365...36,097,244
Ensembl chr19:36,089,361...36,097,499

G

ankyrin repeat domain 6

increases expression

nickel sulfate results in increased expression of ANKRD6 mRNA

NCBI chr 4:32,804,027...32,950,884
Ensembl chr 4:32,804,035...32,950,841

G

anoctamin 2

decreases expression

nickel sulfate results in decreased expression of ANO2 mRNA

NCBI chr 6:125,667,382...126,017,115
Ensembl chr 6:125,667,382...126,017,089

G

alanyl aminopeptidase, membrane

decreases expression

nickel sulfate results in decreased expression of ANPEP mRNA

NCBI chr 7:79,471,551...79,497,958
Ensembl chr 7:79,471,551...79,510,807

G

anthrax toxin receptor 1

increases expression

nickel sulfate results in increased expression of ANTXR1 mRNA

NCBI chr 6:87,110,835...87,312,757
Ensembl chr 6:87,110,835...87,312,803

G

anthrax toxin receptor 2

increases expression
decreases expression

nickel sulfate results in increased expression of ANTXR2 mRNA
nickel sulfate results in decreased expression of ANTXR2 mRNA

PMID:16780908 PMID:22714537

NCBI chr 5:98,032,547...98,178,876
Ensembl chr 5:98,030,642...98,178,902

G

annexin A1

increases expression

nickel sulfate results in increased expression of ANXA1 mRNA

NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308

G

annexin A2

increases expression

nickel sulfate results in increased expression of ANXA2 mRNA

NCBI chr 9:69,360,978...69,399,074
Ensembl chr 9:69,360,902...69,399,077

G

annexin A3

decreases expression

nickel sulfate results in decreased expression of ANXA3 mRNA

NCBI chr 5:96,941,257...96,993,825
Ensembl chr 5:96,941,198...96,993,825

G

amine oxidase, copper-containing 1

increases expression

nickel sulfate results in increased expression of AOC1 mRNA

NCBI chr 6:48,872,189...48,886,122
Ensembl chr 6:48,849,830...48,886,122

G

aldehyde oxidase 1

decreases expression

nickel sulfate results in decreased expression of AOX1 mRNA

NCBI chr 1:58,068,963...58,145,569
Ensembl chr 1:58,069,090...58,145,572

G

adaptor-related protein complex 1 associated regulatory protein

decreases expression

nickel sulfate results in decreased expression of AP1AR mRNA

NCBI chr 3:127,600,656...127,631,148
Ensembl chr 3:127,600,656...127,631,172

G

amyloid beta precursor protein binding family A member 2

increases expression

nickel sulfate results in increased expression of APBA2 mRNA

NCBI chr 7:64,151,444...64,403,620
Ensembl chr 7:64,151,454...64,403,626

G

adipocyte plasma membrane associated protein

decreases expression

nickel sulfate results in decreased expression of APMAP mRNA

NCBI chr 2:150,425,000...150,450,487
Ensembl chr 2:150,425,000...150,450,487

G

apolipoprotein E

decreases expression
increases expression

nickel sulfate results in decreased expression of APOE mRNA
nickel sulfate results in increased expression of APOE mRNA

NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113

G

apolipoprotein L 6

increases expression

nickel sulfate results in increased expression of APOL6 mRNA

NCBI chr15:76,929,195...76,941,308
Ensembl chr15:76,928,929...76,941,306

G

aquaporin 3

decreases expression

nickel sulfate results in decreased expression of AQP3 mRNA

PMID:16780908 PMID:20713136

NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183

G

aquaporin 9

decreases expression

nickel sulfate results in decreased expression of AQP9 mRNA

NCBI chr 9:71,017,941...71,075,170
Ensembl chr 9:71,017,941...71,075,964

G

androgen receptor

increases expression

nickel sulfate results in increased expression of AR mRNA

NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

decreases expression

nickel sulfate results in decreased expression of ARAP2 mRNA

NCBI chr 5:62,759,788...62,923,874
Ensembl chr 5:62,759,788...62,923,502

G

amphiregulin

increases expression
decreases expression

nickel sulfate results in increased expression of AREG mRNA
nickel sulfate results in decreased expression of AREG mRNA

PMID:16166746 PMID:18651567 PMID:22714537

NCBI chr 5:91,287,458...91,296,291
Ensembl chr 5:91,287,458...91,296,291

G

ADP-ribosylation factor interacting protein 2

increases expression

nickel sulfate results in increased expression of ARFIP2 mRNA

NCBI chr 7:105,283,408...105,289,623
Ensembl chr 7:105,283,410...105,289,623

G

arginase type II

increases expression

nickel sulfate results in increased expression of ARG2 mRNA

NCBI chr12:79,177,562...79,203,075
Ensembl chr12:79,177,551...79,203,075

G

Rho GTPase activating protein 17

decreases expression

nickel sulfate results in decreased expression of ARHGAP17 mRNA

NCBI chr 7:122,878,372...122,969,171
Ensembl chr 7:122,878,441...122,969,138

G

Rho GTPase activating protein 18

increases expression

nickel sulfate results in increased expression of ARHGAP18 mRNA

NCBI chr10:26,648,363...26,794,644
Ensembl chr10:26,629,417...26,794,644

G

Rho GTPase activating protein 42

decreases expression

nickel sulfate results in decreased expression of ARHGAP42 mRNA

NCBI chr 9:8,992,508...9,239,032
Ensembl chr 9:8,994,330...9,239,106

G

Rho GTPase activating protein 44

increases expression

nickel sulfate results in increased expression of ARHGAP44 mRNA

NCBI chr11:64,892,865...65,053,779
Ensembl chr11:64,892,865...65,053,787

G

Rho GTPase activating protein 5

decreases expression

nickel sulfate results in decreased expression of ARHGAP5 mRNA

NCBI chr12:52,550,555...52,618,761
Ensembl chr12:52,550,755...52,618,758

G

CDC42 guanine nucleotide exchange factor 9

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of ARHGEF9 mRNA

NCBI chr X:94,092,536...94,240,801
Ensembl chr X:94,092,541...94,240,462

G

ADP-ribosylation factor-like 10

decreases expression

nickel sulfate results in decreased expression of ARL10 mRNA

NCBI chr13:54,722,860...54,730,578
Ensembl chr13:54,722,828...54,728,941

G

ADP-ribosylation factor-like 4C

increases expression

nickel sulfate results in increased expression of ARL4C mRNA

PMID:17374397 PMID:18651567

NCBI chr 1:88,625,947...88,629,913
Ensembl chr 1:88,600,847...88,629,943

G

armadillo repeat containing, X-linked 1

decreases expression

nickel sulfate results in decreased expression of ARMCX1 mRNA

NCBI chr X:133,618,615...133,623,487
Ensembl chr X:133,618,712...133,622,666

G

armadillo repeat containing, X-linked 2

decreases expression

nickel sulfate results in decreased expression of ARMCX2 mRNA

NCBI chr X:133,704,891...133,709,970
Ensembl chr X:133,704,894...133,709,970

G

armadillo repeat containing, X-linked 4

decreases expression

nickel sulfate results in decreased expression of ARMCX4 mRNA

NCBI chr X:133,586,399...133,598,524
Ensembl chr X:133,587,268...133,597,506

G

aryl hydrocarbon receptor nuclear translocator

affects localization

nickel sulfate affects the localization of ARNT protein

NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551

G

aryl hydrocarbon receptor nuclear translocator 2

increases expression

nickel sulfate results in increased expression of ARNT2 mRNA

NCBI chr 7:83,895,486...84,059,201
Ensembl chr 7:83,895,486...84,059,384

G

actin related protein 2/3 complex, subunit 2

increases expression

nickel sulfate results in increased expression of ARPC2 mRNA

NCBI chr 1:74,275,656...74,307,368
Ensembl chr 1:74,275,243...74,307,368

G

actin related protein 2/3 complex, subunit 4

increases expression

nickel sulfate results in increased expression of ARPC4 mRNA

NCBI chr 6:113,355,074...113,367,408
Ensembl chr 6:113,355,076...113,367,409

G

arrestin, beta 1

increases expression

nickel sulfate results in increased expression of ARRB1 mRNA

NCBI chr 7:99,184,356...99,255,979
Ensembl chr 7:99,184,673...99,255,978

G

N-acylsphingosine amidohydrolase 1

decreases expression

nickel sulfate results in decreased expression of ASAH1 mRNA

NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810

G

asialoglycoprotein receptor 1

decreases expression

nickel sulfate results in decreased expression of ASGR1 mRNA

NCBI chr11:69,939,735...69,948,721
Ensembl chr11:69,944,911...69,948,720

G

asialoglycoprotein receptor 2

decreases expression

nickel sulfate results in decreased expression of ASGR2 mRNA

NCBI chr11:69,983,470...69,997,013
Ensembl chr11:69,983,470...69,997,013

G

argininosuccinate synthetase 1

increases expression

nickel sulfate results in increased expression of ASS1 mRNA

NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684

G

alpha tubulin acetyltransferase 1

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of ATAT1 mRNA

NCBI chr17:36,208,487...36,220,971
Ensembl chr17:36,208,487...36,220,967

G

activating transcription factor 3

increases expression

nickel sulfate results in increased expression of ATF3 mRNA

NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236

G

activating transcription factor 6

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of ATF6 mRNA

NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340

G

atlastin GTPase 1

decreases expression

nickel sulfate results in decreased expression of ATL1 mRNA

NCBI chr12:69,939,879...70,010,859
Ensembl chr12:69,939,388...70,013,191

G

atlastin GTPase 3

decreases expression

nickel sulfate results in decreased expression of ATL3 mRNA

NCBI chr19:7,471,178...7,515,974
Ensembl chr19:7,471,405...7,517,039

G

ATPase, class VI, type 11A

decreases expression

nickel sulfate results in decreased expression of ATP11A mRNA

NCBI chr 8:12,807,016...12,918,728
Ensembl chr 8:12,807,014...12,918,728

G

ATPase, Na+/K+ transporting, beta 1 polypeptide

decreases expression

nickel sulfate results in decreased expression of ATP1B1 mRNA

NCBI chr 1:164,264,668...164,285,924
Ensembl chr 1:164,264,678...164,285,924

G

ATPase, Na+/K+ transporting, beta 3 polypeptide

increases expression
decreases expression

nickel sulfate results in increased expression of ATP1B3 mRNA
nickel sulfate results in decreased expression of ATP1B3 mRNA

PMID:16780908 PMID:18651567

NCBI chr 9:96,214,708...96,246,368
Ensembl chr 9:96,214,708...96,246,495

G

ATPase, Ca++ transporting, plasma membrane 4

decreases expression

nickel sulfate results in decreased expression of ATP2B4 mRNA

NCBI chr 1:133,630,416...133,728,755
Ensembl chr 1:133,627,195...133,728,779

G

ATPase, H+ transporting, lysosomal V1 subunit A

decreases expression

nickel sulfate results in decreased expression of ATP6V1A mRNA

NCBI chr16:43,905,765...43,960,055
Ensembl chr16:43,905,765...43,960,068

G

ATPase, class I, type 8B, member 2

decreases expression

nickel sulfate results in decreased expression of ATP8B2 mRNA

NCBI chr 3:89,846,795...89,870,645
Ensembl chr 3:89,846,788...89,870,815

G

ATPase, class II, type 9A

increases expression

nickel sulfate results in increased expression of ATP9A mRNA

NCBI chr 2:168,476,358...168,584,290
Ensembl chr 2:168,476,358...168,584,329

G

attractin

decreases expression

nickel sulfate results in decreased expression of ATRN mRNA

NCBI chr 2:130,734,363...130,872,249
Ensembl chr 2:130,748,415...130,872,253

G

ataxin 1

increases expression

nickel sulfate results in increased expression of ATXN1 mRNA

NCBI chr13:45,703,231...46,118,467
Ensembl chr13:45,703,231...46,118,484

G

ataxin 7-like 1

increases expression

nickel sulfate results in increased expression of ATXN7L1 mRNA

NCBI chr12:33,196,967...33,426,407
Ensembl chr12:33,197,692...33,423,184

G

autism susceptibility candidate 2

increases expression

nickel sulfate results in increased expression of AUTS2 mRNA

NCBI chr 5:131,466,171...132,572,059
Ensembl chr 5:131,466,171...132,572,183

G

antizyme inhibitor 1

decreases expression

nickel sulfate results in decreased expression of AZIN1 mRNA

NCBI chr15:38,487,674...38,523,506
Ensembl chr15:38,487,671...38,519,510

G

beta-1,3-glucuronyltransferase 1

decreases expression

nickel sulfate results in decreased expression of B3GAT1 mRNA

NCBI chr 9:26,644,813...26,672,646
Ensembl chr 9:26,645,024...26,674,397

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

increases expression

nickel sulfate results in increased expression of B3GNT5 mRNA

NCBI chr16:19,578,943...19,591,508
Ensembl chr16:19,578,958...19,591,503

G

beta-1,4-N-acetyl-galactosaminyl transferase 1

increases expression

nickel sulfate results in increased expression of B4GALNT1 mRNA

NCBI chr10:127,001,025...127,008,209
Ensembl chr10:127,001,094...127,008,199

G

BTB and CNC homology 1, basic leucine zipper transcription factor 1

increases expression

nickel sulfate results in increased expression of BACH1 mRNA

NCBI chr16:87,495,842...87,530,234
Ensembl chr16:87,495,833...87,530,234

G

BAI1-associated protein 2-like 1

increases expression

nickel sulfate results in increased expression of BAIAP2L1 mRNA

NCBI chr 5:144,201,335...144,294,922
Ensembl chr 5:144,201,336...144,294,922

G

BCL2-antagonist/killer 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of BAK1 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of BAK1 protein]
nickel sulfate results in increased expression of BAK1 mRNA; nickel sulfate results in increased expression of BAK1 protein

NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983

G

BMP and activin membrane-bound inhibitor

increases expression

nickel sulfate results in increased expression of BAMBI mRNA

NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404

G

BCL2-associated X protein

multiple interactions
increases expression

sesamin inhibits the reaction [nickel sulfate results in increased expression of BAX protein]
pyrazolanthrone inhibits the reaction [nickel sulfate results in increased expression of BAX protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased expression of BAX protein]
nickel sulfate results in increased expression of BAX mRNA; nickel sulfate results in increased expression of BAX protein

PMID:23317420 PMID:35499276

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

Bardet-Biedl syndrome 5

increases expression

nickel sulfate results in increased expression of BBS5 mRNA

NCBI chr 2:69,477,193...69,497,915
Ensembl chr 2:69,477,515...69,497,915

G

breast cancer anti-estrogen resistance 1

decreases expression

nickel sulfate results in decreased expression of BCAR1 mRNA

NCBI chr 8:112,437,106...112,470,481
Ensembl chr 8:112,437,106...112,470,441

G

BCL11 transcription factor A

decreases expression

nickel sulfate results in decreased expression of BCL11A mRNA

NCBI chr11:24,026,498...24,123,558
Ensembl chr11:24,028,056...24,124,123

G

B cell leukemia/lymphoma 2

increases expression
decreases expression
multiple interactions

nickel sulfate results in increased expression of BCL2 protein
nickel sulfate results in decreased expression of BCL2 protein
sesamin inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]; Selenium inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]
nickel sulfate results in decreased expression of BCL2 mRNA; nickel sulfate results in decreased expression of BCL2 protein

PMID:21776270 PMID:23317420 PMID:34612572 PMID:35499276

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

B cell leukemia/lymphoma 2 related protein A1b

increases expression

nickel sulfate results in increased expression of BCL2A1 mRNA

NCBI chr 9:89,081,326...89,089,891
Ensembl chr 9:89,081,262...89,089,880

G

BCL2-like 1

increases expression
multiple interactions
decreases expression

nickel sulfate results in increased expression of BCL2L1 protein
pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of BCL2L1 protein]
nickel sulfate results in decreased expression of BCL2L1 mRNA; nickel sulfate results in decreased expression of BCL2L1 protein

PMID:21776270 PMID:35499276

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

BCL2 like 11

increases expression

nickel sulfate results in increased expression of BCL2L11 mRNA

NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467

G

B cell CLL/lymphoma 9

increases expression

nickel sulfate results in increased expression of BCL9 mRNA

NCBI chr 3:97,110,974...97,205,718
Ensembl chr 3:97,110,978...97,205,233

G

3-hydroxybutyrate dehydrogenase, type 1

decreases expression

nickel sulfate results in decreased expression of BDH1 mRNA

NCBI chr16:31,241,115...31,277,719
Ensembl chr16:31,241,098...31,277,719

G

brain expressed X-linked 2

decreases expression

nickel sulfate results in decreased expression of BEX1 mRNA

NCBI chr X:134,967,314...134,968,985
Ensembl chr X:134,967,313...134,968,985

G

brain expressed X-linked 4

decreases expression

nickel sulfate results in decreased expression of BEX4 mRNA

NCBI chr X:135,039,745...135,041,192
Ensembl chr X:135,039,745...135,041,192

G

basic helix-loop-helix family, member e40

increases expression

nickel sulfate results in increased expression of BHLHE40 mRNA

PMID:18651567 PMID:22714537

NCBI chr 6:108,637,590...108,643,886
Ensembl chr 6:108,637,590...108,643,886

G

BicC family RNA binding protein 1

decreases expression

nickel sulfate results in decreased expression of BICC1 mRNA

NCBI chr10:70,758,660...70,995,581
Ensembl chr10:70,758,662...70,995,530

G

BH3 interacting domain death agonist

increases expression

nickel sulfate results in increased expression of BID mRNA

NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814

G

bridging integrator 1

increases expression

nickel sulfate results in increased expression of BIN1 mRNA

NCBI chr18:32,509,671...32,568,793
Ensembl chr18:32,510,283...32,568,790

G

baculoviral IAP repeat-containing 2

increases expression

nickel sulfate results in increased expression of BIRC2 mRNA

NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065

G

baculoviral IAP repeat-containing 3

increases expression

nickel sulfate results in increased expression of BIRC3 mRNA

NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187

G

baculoviral IAP repeat-containing 5

multiple interactions

nickel sulfate affects the localization of and results in increased expression of BIRC5 protein

NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569

G

Bmi1 polycomb ring finger oncogene

decreases expression

nickel sulfate results in decreased expression of BMI1 mRNA

NCBI chr 2:18,681,953...18,691,440
Ensembl chr 2:18,681,829...18,691,440

G

bone morphogenetic protein 2

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of BMP2 mRNA

NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805

G

bone morphogenetic protein 4

increases expression

nickel sulfate results in increased expression of BMP4 mRNA

NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126

G

bone morphogenetic protein 6

increases expression

nickel sulfate results in increased expression of BMP6 mRNA

PMID:16780908 PMID:17374397

NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278

G

BMP-binding endothelial regulator

decreases expression

nickel sulfate results in decreased expression of BMPER mRNA

NCBI chr 9:23,134,372...23,396,511
Ensembl chr 9:23,134,372...23,396,496

G

BCL2/adenovirus E1B interacting protein 3

increases expression

nickel sulfate results in increased expression of BNIP3 mRNA

NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248

G

BRCA1/BRCA2-containing complex, subunit 3

decreases expression

nickel sulfate results in decreased expression of BRCC3 mRNA

NCBI chr X:74,460,234...74,499,307
Ensembl chr X:74,460,234...74,497,607

G

bromodomain containing 2

decreases expression

nickel sulfate results in decreased expression of BRD2 mRNA

NCBI chr17:34,330,993...34,341,581
Ensembl chr17:34,330,997...34,341,608

G

bone marrow stromal cell antigen 2

increases expression

nickel sulfate results in increased expression of BST2 mRNA

NCBI chr 8:71,986,899...71,990,116
Ensembl chr 8:71,986,899...71,990,100

G

BTB domain containing 2

increases expression

nickel sulfate results in increased expression of BTBD2 mRNA

NCBI chr10:80,478,457...80,492,328
Ensembl chr10:80,478,451...80,492,328

G

BTB domain containing 3

decreases expression

nickel sulfate results in decreased expression of BTBD3 mRNA

NCBI chr 2:138,098,478...138,129,344
Ensembl chr 2:138,098,485...138,431,212

G

BTG anti-proliferation factor 1

increases expression

nickel sulfate results in increased expression of BTG1 mRNA

PMID:16780908 PMID:17374397 PMID:22714537

NCBI chr10:96,452,863...96,458,675
Ensembl chr10:96,452,868...96,458,671

G

BUB1, mitotic checkpoint serine/threonine kinase

decreases expression

nickel sulfate results in decreased expression of BUB1 mRNA

NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785

G

complement component 1, q subcomponent, alpha polypeptide

decreases expression

nickel sulfate results in decreased expression of C1QA mRNA

NCBI chr 4:136,623,227...136,626,155
Ensembl chr 4:136,623,228...136,626,114

G

complement component 1, q subcomponent, beta polypeptide

decreases expression

nickel sulfate results in decreased expression of C1QB mRNA

NCBI chr 4:136,607,437...136,613,511
Ensembl chr 4:136,607,440...136,613,498

G

complement component 1, q subcomponent, C chain

decreases expression

nickel sulfate results in decreased expression of C1QC mRNA

NCBI chr 4:136,617,115...136,620,225
Ensembl chr 4:136,617,115...136,620,376

G

complement component 1, q subcomponent-like 4

increases expression

nickel sulfate results in increased expression of C1QL4 mRNA

NCBI chr15:98,981,967...98,988,555
Ensembl chr15:98,981,967...98,985,698

G

complement component 1, r subcomponent B

increases expression

nickel sulfate results in increased expression of C1R mRNA

NCBI chr 6:124,547,389...124,558,003
Ensembl chr 6:124,547,253...124,558,130

G

complement component 1, s subcomponent 1

increases expression

nickel sulfate results in increased expression of C1S mRNA

NCBI chr 6:124,507,303...124,519,340
Ensembl chr 6:124,507,304...124,519,318

G

CDK5 and Abl enzyme substrate 1

increases expression

nickel sulfate results in increased expression of CABLES1 mRNA

NCBI chr18:11,972,600...12,078,681
Ensembl chr18:11,972,277...12,078,687

G

cache domain containing 1

increases expression

nickel sulfate results in increased expression of CACHD1 mRNA

NCBI chr 4:100,633,870...100,861,741
Ensembl chr 4:100,633,872...100,886,417

G

calcium channel, voltage-dependent, alpha 1I subunit

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of CACNA1I mRNA

NCBI chr15:80,171,439...80,282,493
Ensembl chr15:80,171,439...80,282,480

G

calcitonin receptor-like

increases expression

nickel sulfate results in increased expression of CALCRL mRNA

PMID:16780908 PMID:17374397

NCBI chr 2:84,160,970...84,255,786
Ensembl chr 2:84,160,970...84,255,755

G

calcium/calmodulin-dependent protein kinase I

increases expression

nickel sulfate results in increased expression of CAMK1 mRNA

NCBI chr 6:113,311,085...113,320,883
Ensembl chr 6:113,311,085...113,320,945

G

calnexin

decreases expression

nickel sulfate results in decreased expression of CANX mRNA

NCBI chr11:50,184,784...50,216,500
Ensembl chr11:50,184,788...50,216,500

G

caprin family member 2

increases expression

nickel sulfate results in increased expression of CAPRIN2 mRNA

NCBI chr 6:148,743,990...148,797,756
Ensembl chr 6:148,743,990...148,797,735

G

carbonic anhydrase 13

decreases expression

nickel sulfate results in decreased expression of CA13 mRNA

NCBI chr 3:14,706,787...14,728,062
Ensembl chr 3:14,706,787...14,728,062

G

carbonic anhydrase 2

decreases expression

nickel sulfate results in decreased expression of CA2 mRNA

PMID:16780908 PMID:17374397

NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830

G

carbonic anhydrase 9

multiple interactions
increases expression
decreases expression

Ascorbic Acid inhibits the reaction [nickel sulfate results in increased expression of CA9 protein]
nickel sulfate results in decreased expression of CA9 mRNA

PMID:16288478 PMID:22714537

NCBI chr 4:43,507,026...43,513,729
Ensembl chr 4:43,506,966...43,513,729

G

caspase recruitment domain family, member 10

increases expression

nickel sulfate results in increased expression of CARD10 mRNA

NCBI chr15:78,659,323...78,687,261
Ensembl chr15:78,659,338...78,687,242

G

capping protein regulator and myosin 1 linker 1

increases expression

nickel sulfate results in increased expression of CARMIL1 mRNA

NCBI chr13:24,196,464...24,464,983
Ensembl chr13:24,196,327...24,464,778

G

calcium/calmodulin dependent serine protein kinase

decreases expression

nickel sulfate results in decreased expression of CASK mRNA

NCBI chr X:13,383,319...13,713,020
Ensembl chr X:13,383,319...13,717,606

G

caspase 12

increases expression
multiple interactions

nickel sulfate results in increased expression of CASP12 mRNA; nickel sulfate results in increased expression of CASP12 protein
Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP12 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP12 protein]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP12 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP12 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP12 protein]

PMID:28296042 PMID:34612572

NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032

G

caspase 3

multiple interactions
increases cleavage
increases expression
decreases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in decreased expression of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein modified form]]; nickel sulfate inhibits the reaction [Potassium Dichromate results in increased cleavage of and results in increased activity of CASP3 protein]; nickel sulfate results in increased cleavage of and results in increased activity of CASP3 protein; nickel sulfate results in increased expression of and results in increased cleavage of CASP3 protein; Potassium Dichromate inhibits the reaction [nickel sulfate results in increased cleavage of and results in increased activity of CASP3 protein]; Selenium inhibits the reaction [nickel sulfate results in decreased expression of CASP3 protein]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein modified form]
nickel sulfate results in increased cleavage of CASP3 protein
sesamin inhibits the reaction [nickel sulfate results in increased cleavage of CASP3 protein]
Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein modified form]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein]
nickel sulfate results in increased expression of CASP3 protein; nickel sulfate results in increased expression of CASP3 protein modified form
nickel sulfate results in increased expression of CASP3 mRNA; nickel sulfate results in increased expression of CASP3 protein modified form

PMID:20493934 PMID:23317420 PMID:28296042 PMID:34612572 PMID:35499276

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 9

increases expression
multiple interactions

nickel sulfate results in increased expression of CASP9 mRNA; nickel sulfate results in increased expression of CASP9 protein
Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP9 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]

PMID:28296042 PMID:34612572

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

increases expression
multiple interactions
decreases activity
increases activity

nickel sulfate results in increased expression of CAT mRNA
naringin inhibits the reaction [nickel sulfate results in decreased activity of CAT protein]; Selenium inhibits the reaction [nickel sulfate results in increased activity of CAT protein]; Zinc inhibits the reaction [nickel sulfate results in increased activity of CAT protein]
sesamin inhibits the reaction [nickel sulfate results in decreased activity of CAT protein]

PMID:15535990 PMID:20566472 PMID:20950607 PMID:23317420 PMID:34612572

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

Casitas B-lineage lymphoma b

increases expression

nickel sulfate results in increased expression of CBLB mRNA

NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411

G

carbonyl reductase 2

decreases expression

nickel sulfate results in decreased expression of CBR2 mRNA

NCBI chr11:120,620,311...120,622,851
Ensembl chr11:120,620,315...120,622,940

G

chromobox 2

increases expression

nickel sulfate results in increased expression of CBX2 mRNA

NCBI chr11:118,913,845...118,922,101
Ensembl chr11:118,913,788...118,922,096

G

coiled-coil domain containing 167

increases expression

nickel sulfate results in increased expression of CCDC167 mRNA

NCBI chr17:29,914,951...29,935,991
Ensembl chr17:29,906,331...29,936,018

G

coiled-coil domain containing 169

decreases expression

nickel sulfate results in decreased expression of CCDC169 mRNA

NCBI chr 3:55,044,760...55,082,671
Ensembl chr 3:55,044,760...55,080,356

G

coiled-coil domain containing 18

decreases expression

nickel sulfate results in decreased expression of CCDC18 mRNA

NCBI chr 5:108,280,583...108,388,378
Ensembl chr 5:108,280,741...108,381,494

G

coiled-coil domain containing 3

increases expression

nickel sulfate results in increased expression of CCDC3 mRNA

NCBI chr 2:5,142,587...5,235,682
Ensembl chr 2:5,142,587...5,235,689

G

coiled-coil domain containing 68

increases expression

nickel sulfate results in increased expression of CCDC68 mRNA

NCBI chr18:70,057,929...70,102,559
Ensembl chr18:70,058,497...70,102,555

G

coiled-coil domain containing 80

decreases expression

nickel sulfate results in decreased expression of CCDC80 mRNA

NCBI chr16:44,913,770...44,948,287
Ensembl chr16:44,913,765...44,948,440

G

coiled-coil domain containing 88C

increases expression

nickel sulfate results in increased expression of CCDC88C mRNA

NCBI chr12:100,877,778...100,995,610
Ensembl chr12:100,877,782...100,995,315

G

C-C motif chemokine ligand 1

increases expression

nickel sulfate results in increased expression of CCL1 mRNA

NCBI chr11:82,067,492...82,070,638
Ensembl chr11:82,067,483...82,196,516

G

C-C motif chemokine ligand 11

increases expression
affects expression
decreases expression

nickel sulfate results in increased expression of CCL11 mRNA
nickel sulfate affects the expression of CCL11 mRNA
nickel sulfate results in decreased expression of CCL11 mRNA

PMID:16166746 PMID:18202158 PMID:18832182

NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781

G

C-C motif chemokine ligand 12

decreases expression

nickel sulfate results in decreased expression of CCL13 mRNA

NCBI chr11:81,992,671...81,994,225
Ensembl chr11:81,992,671...81,994,226

G

C-C motif chemokine ligand 17

affects expression
increases expression

nickel sulfate affects the expression of CCL17 mRNA
nickel sulfate results in increased expression of CCL17 mRNA

PMID:16166746 PMID:18202158

NCBI chr 8:95,535,996...95,538,666
Ensembl chr 8:95,537,081...95,538,664

G

C-C motif chemokine ligand 2

decreases expression
increases expression
multiple interactions

nickel sulfate results in decreased expression of CCL2 mRNA
nickel sulfate results in increased expression of CCL2 mRNA
[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of CCL2 mRNA

PMID:12060402 PMID:15585374 PMID:16100012 PMID:16166746 PMID:16780908 More...

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 20

multiple interactions
increases secretion

IL1A protein affects the reaction [nickel sulfate results in increased secretion of CCL20 protein]; TNF protein affects the reaction [nickel sulfate results in increased secretion of CCL20 protein]

PMID:15679580 PMID:16099135

NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888

G

C-C motif chemokine ligand 22

affects expression
increases expression

nickel sulfate affects the expression of CCL22 mRNA
nickel sulfate results in increased expression of CCL22 mRNA

PMID:12060402 PMID:16166746 PMID:18202158

NCBI chr 8:95,472,312...95,478,016
Ensembl chr 8:95,472,218...95,478,327

G

C-C motif chemokine ligand 27A

increases secretion

nickel sulfate results in increased secretion of CCL27 protein

NCBI chr 4:41,769,467...41,774,251
Ensembl chr 4:41,769,467...41,774,247

G

C-C motif chemokine ligand 28

decreases expression

nickel sulfate results in decreased expression of CCL28 mRNA

NCBI chr13:120,085,355...120,115,895
Ensembl chr13:120,085,355...120,115,895

G

C-C motif chemokine ligand 3

affects expression
increases expression

nickel sulfate affects the expression of CCL3 mRNA
nickel sulfate results in increased expression of CCL3 mRNA

PMID:15585374 PMID:16780908 PMID:18202158 PMID:19732821

NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181

G

C-C motif chemokine ligand 4

increases secretion
increases expression

nickel sulfate results in increased secretion of CCL4 protein
nickel sulfate results in increased expression of CCL4 mRNA; nickel sulfate results in increased expression of CCL4 protein

PMID:12060402 PMID:15585374 PMID:16314067 PMID:16780908 PMID:18353026 More...

NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509

G

C-C motif chemokine ligand 5

affects expression
increases secretion

nickel sulfate affects the expression of CCL5 mRNA
nickel sulfate results in increased secretion of CCL5 protein

PMID:16099135 PMID:18202158

NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344

G

C-C motif chemokine ligand 7

increases expression

nickel sulfate results in increased expression of CCL7 mRNA

NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351

G

C-C motif chemokine receptor 1

affects expression

nickel sulfate affects the expression of CCR1 mRNA

NCBI chr 9:123,762,163...123,768,729
Ensembl chr 9:123,762,161...123,768,729

G

C-C motif chemokine receptor 2

decreases expression

nickel sulfate results in decreased expression of CCR2 mRNA

NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594

G

C-C motif chemokine receptor 6

decreases expression

nickel sulfate results in decreased expression of CCR6 protein

NCBI chr17:8,454,875...8,477,353
Ensembl chr17:8,454,875...8,475,973

G

C-C motif chemokine receptor 7

affects expression
increases expression

nickel sulfate affects the expression of CCR7 mRNA
nickel sulfate results in increased expression of CCR7 mRNA

PMID:15304089 PMID:16780908 PMID:17374397 PMID:18202158 PMID:21697260

NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903

G

C-C motif chemokine receptor 8

affects expression
increases expression

nickel sulfate affects the expression of CCR8 mRNA
nickel sulfate results in increased expression of CCR8 mRNA

PMID:11145678 PMID:18202158

NCBI chr 9:119,921,199...119,923,972
Ensembl chr 9:119,921,180...119,923,972

G

CD200 molecule

decreases expression
multiple interactions

nickel sulfate results in decreased expression of CD200 mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of CD200 mRNA

PMID:22714537 PMID:31734292

NCBI chr16:45,202,474...45,229,419
Ensembl chr16:45,202,498...45,229,416

G

CD207 antigen

multiple interactions
decreases expression

pyrazolanthrone promotes the reaction [nickel sulfate results in decreased expression of CD207 protein]

NCBI chr 6:83,648,189...83,654,839
Ensembl chr 6:83,648,197...83,654,839

G

CD274 antigen

increases expression
decreases expression

nickel sulfate results in increased expression of CD274 protein
nickel sulfate results in decreased expression of CD274 mRNA

PMID:22714537 PMID:25673294

NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495

G

CD276 antigen

increases expression

nickel sulfate results in increased expression of CD276 mRNA

NCBI chr 9:58,431,581...58,463,437
Ensembl chr 9:58,431,581...58,462,720

G

CD36 molecule

decreases expression

nickel sulfate results in decreased expression of CD36 mRNA

PMID:16780908 PMID:17374397

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

G

CD40 antigen

multiple interactions
increases expression

BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of CD40 protein]

PMID:17636246 PMID:25673294

NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868

G

CD68 antigen

increases expression

nickel sulfate results in increased expression of CD68 mRNA

NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979

G

CD69 antigen

increases expression

nickel sulfate results in increased expression of CD69 mRNA

NCBI chr 6:129,244,287...129,252,332
Ensembl chr 6:129,244,288...129,252,399

G

CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

decreases expression

nickel sulfate results in decreased expression of CD74 mRNA

NCBI chr18:60,936,921...60,945,724
Ensembl chr18:60,936,920...60,945,724

G

CD79A antigen (immunoglobulin-associated alpha)

decreases expression

nickel sulfate results in decreased expression of CD79A mRNA

NCBI chr 7:24,596,922...24,601,283
Ensembl chr 7:24,596,806...24,601,622

G

CD80 antigen

increases expression

nickel sulfate results in increased expression of CD80 protein

NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697

G

CD82 antigen

increases expression

nickel sulfate results in increased expression of CD82 mRNA

NCBI chr 2:93,249,447...93,293,295
Ensembl chr 2:93,249,456...93,293,485

G

CD83 antigen

increases expression
multiple interactions

nickel sulfate results in increased expression of CD83 mRNA; nickel sulfate results in increased expression of CD83 protein
BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of CD83 protein]; lipopolysaccharide, E coli O55-B5 promotes the reaction [nickel sulfate results in increased expression of CD83 protein]; TNF protein promotes the reaction [nickel sulfate results in increased expression of CD83 protein]

PMID:16099135 PMID:16780908 PMID:17636246 PMID:21697260 PMID:25673294

NCBI chr13:43,938,661...43,956,608
Ensembl chr13:43,938,251...43,956,608

G

CD86 antigen

increases expression
multiple interactions
affects expression

nickel sulfate results in increased expression of CD86 mRNA; nickel sulfate results in increased expression of CD86 protein
Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CD86 protein]; BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of CD86 protein]
nickel sulfate affects the expression of CD86 mRNA

PMID:16099135 PMID:16780908 PMID:17374397 PMID:17636246 PMID:18202158 More...

NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443

G

CD8 subunit alpha

increases expression

nickel sulfate results in increased expression of CD8A mRNA

NCBI chr 6:71,350,411...71,356,155
Ensembl chr 6:71,350,411...71,356,157

G

CD99 antigen

increases expression

nickel sulfate results in increased expression of CD99 mRNA

G

cell division cycle 25B

decreases expression

nickel sulfate results in decreased expression of CDC25B mRNA

NCBI chr 2:131,028,356...131,040,431
Ensembl chr 2:131,028,869...131,040,417

G

cell division cycle 34

increases expression

nickel sulfate results in increased expression of CDC34 mRNA

NCBI chr10:79,518,029...79,524,232
Ensembl chr10:79,518,029...79,524,232

G

cadherin 1

decreases expression
multiple interactions

nickel sulfate results in decreased expression of CDH1 mRNA; nickel sulfate results in decreased expression of CDH1 protein
pyrazolanthrone promotes the reaction [nickel sulfate results in decreased expression of CDH1 protein]

PMID:15588916 PMID:16780908 PMID:22648416

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

cadherin 13

decreases expression

nickel sulfate results in decreased expression of CDH13 mRNA

NCBI chr 8:119,010,150...120,051,668
Ensembl chr 8:119,010,472...120,051,660

G

cadherin 16

decreases expression

nickel sulfate results in decreased expression of CDH16 mRNA

NCBI chr 8:105,328,547...105,351,028
Ensembl chr 8:105,328,543...105,351,028

G

cadherin 3

decreases expression

nickel sulfate results in decreased expression of CDH3 mRNA

NCBI chr 8:107,237,484...107,283,543
Ensembl chr 8:107,237,523...107,283,929

G

cadherin 8

decreases expression

nickel sulfate results in decreased expression of CDH8 mRNA

NCBI chr 8:99,751,103...100,144,298
Ensembl chr 8:99,751,103...100,143,103

G

cyclin dependent kinase 10

increases expression

nickel sulfate results in increased expression of CDK10 mRNA

NCBI chr 8:123,951,580...123,958,995
Ensembl chr 8:123,951,581...123,958,989

G

cyclin dependent kinase 14

decreases expression

nickel sulfate results in decreased expression of CDK14 mRNA

NCBI chr 5:4,853,384...5,430,650
Ensembl chr 5:4,853,391...5,470,312

G

cyclin dependent kinase 6

decreases expression

nickel sulfate results in decreased expression of CDK6 mRNA

NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008

G

cyclin dependent kinase like 2

increases expression

nickel sulfate results in increased expression of CDKL2 mRNA

NCBI chr 5:92,153,933...92,198,479
Ensembl chr 5:92,153,933...92,191,742

G

cyclin dependent kinase like 5

decreases expression

nickel sulfate results in decreased expression of CDKL5 mRNA

NCBI chr X:159,567,241...159,777,673
Ensembl chr X:159,554,919...159,777,700

G

cyclin dependent kinase inhibitor 1A

increases expression

nickel sulfate results in increased expression of CDKN1A mRNA

PMID:16100012 PMID:16166746 PMID:16314067

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

cyclin dependent kinase inhibitor 2D

increases expression

nickel sulfate results in increased expression of CDKN2D mRNA

NCBI chr 9:21,199,759...21,202,553
Ensembl chr 9:21,199,706...21,202,703

G

cysteine dioxygenase 1, cytosolic

decreases expression

nickel sulfate results in decreased expression of CDO1 mRNA

NCBI chr18:46,846,260...46,861,569
Ensembl chr18:46,846,260...46,861,462

G

CDP-diacylglycerol synthase 2

decreases expression

nickel sulfate results in decreased expression of CDS2 mRNA

NCBI chr 2:132,105,068...132,153,970
Ensembl chr 2:132,105,068...132,153,970

G

chromatin licensing and DNA replication factor 1

increases expression

nickel sulfate results in increased expression of CDT1 mRNA

NCBI chr 8:123,294,754...123,299,869
Ensembl chr 8:123,294,754...123,300,293

G

choline/ethanolaminephosphotransferase 1

decreases expression

nickel sulfate results in decreased expression of CEPT1 mRNA

NCBI chr 3:106,409,576...106,455,118
Ensembl chr 3:106,409,576...106,455,118

G

ceramide kinase-like

decreases expression

nickel sulfate results in decreased expression of CERKL mRNA

NCBI chr 2:79,162,835...79,259,332
Ensembl chr 2:79,160,887...79,287,129

G

ceramide synthase 6

increases expression

nickel sulfate results in increased expression of LASS6 mRNA

NCBI chr 2:68,691,489...68,944,628
Ensembl chr 2:68,691,785...68,944,626

G

cilia and flagella associated protein 119

increases expression

nickel sulfate results in increased expression of CFAP119 mRNA

NCBI chr 7:127,182,527...127,187,819
Ensembl chr 7:127,181,555...127,187,767

G

cilia and flagella associated protein 251

decreases expression

nickel sulfate results in decreased expression of CFAP251 mRNA

NCBI chr 5:123,390,196...123,465,547
Ensembl chr 5:123,390,165...123,465,547

G

cilia and flagella associated protein 44

decreases expression

nickel sulfate results in decreased expression of CFAP44 mRNA

NCBI chr16:44,215,103...44,303,057
Ensembl chr16:44,215,159...44,302,791

G

cilia and flagella associated protein 69

increases expression

nickel sulfate results in increased expression of CFAP69 mRNA

NCBI chr 5:5,629,284...5,714,232
Ensembl chr 5:5,629,278...5,714,239

G

CASP8 and FADD-like apoptosis regulator

increases expression

nickel sulfate results in increased expression of CFLAR mRNA

NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043

G

glycoprotein hormones, alpha subunit

increases expression
multiple interactions

nickel sulfate results in increased expression of CGA mRNA
[CGA protein co-treated with nickel sulfate] results in decreased expression of CYP11A1 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP11A1 protein; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 protein; [CGA protein co-treated with nickel sulfate] results in decreased expression of HSD17B3 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of STAR mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of STAR protein

PMID:18651567 PMID:29567110

NCBI chr 4:34,893,779...34,907,374
Ensembl chr 4:34,893,779...34,907,370

G

chromodomain helicase DNA binding protein 1-like

decreases expression

nickel sulfate results in decreased expression of CHD1L mRNA

NCBI chr 3:97,468,056...97,517,538
Ensembl chr 3:97,468,058...97,517,519

G

choline kinase alpha

increases expression

nickel sulfate results in increased expression of CHKA mRNA

NCBI chr19:3,901,585...3,944,368
Ensembl chr19:3,901,773...3,944,369

G

charged multivesicular body protein 1A

increases expression

nickel sulfate results in increased expression of CHMP1A mRNA

NCBI chr 8:123,931,000...123,939,527
Ensembl chr 8:123,931,003...123,939,502

G

chordin-like 1

decreases expression

nickel sulfate results in decreased expression of CHRDL1 mRNA

NCBI chr X:142,068,670...142,177,282
Ensembl chr X:142,068,670...142,177,258

G

carbohydrate sulfotransferase 11

decreases expression

nickel sulfate results in decreased expression of CHST11 mRNA

NCBI chr10:82,820,274...83,031,738
Ensembl chr10:82,821,332...83,031,734

G

carbohydrate sulfotransferase 15

decreases expression

nickel sulfate results in decreased expression of CHST15 mRNA

NCBI chr 7:131,837,508...131,919,227
Ensembl chr 7:131,837,509...131,918,957

G

cell death-inducing DNA fragmentation factor, alpha subunit-like effector A

multiple interactions
decreases expression

[nickel sulfate co-treated with Particulate Matter] results in decreased expression of CIDEA mRNA
nickel sulfate results in decreased expression of CIDEA mRNA

NCBI chr18:67,476,634...67,500,864
Ensembl chr18:67,476,674...67,500,855

G

cell death-inducing DFFA-like effector c

increases expression

nickel sulfate results in increased expression of CIDEC mRNA

PMID:16780908 PMID:17374397

NCBI chr 6:113,401,595...113,412,721
Ensembl chr 6:113,401,595...113,412,721

G

CDGSH iron sulfur domain 1

decreases expression

nickel sulfate results in decreased expression of CISD1 mRNA

NCBI chr10:71,166,324...71,180,679
Ensembl chr10:71,166,310...71,180,784

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

decreases expression

nickel sulfate results in decreased expression of CITED2 mRNA

NCBI chr10:17,598,452...17,601,422
Ensembl chr10:17,598,966...17,601,422

G

creatine kinase, brain

decreases expression

nickel sulfate results in decreased expression of CKB mRNA

NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772

G

chloride channel, voltage-sensitive 4

increases expression

nickel sulfate results in increased expression of CLCN4 mRNA

NCBI chr 7:7,285,308...7,303,837
Ensembl chr 7:7,285,308...7,303,850

G

claudin 11

increases expression

nickel sulfate results in increased expression of CLDN11 mRNA

NCBI chr 3:31,204,069...31,218,475
Ensembl chr 3:31,204,069...31,218,473

G

chloride intracellular channel 4

increases expression

nickel sulfate results in increased expression of CLIC4 mRNA

NCBI chr 4:134,941,280...135,000,071
Ensembl chr 4:134,941,280...135,000,125

G

CAP-GLY domain containing linker protein 2

increases expression

nickel sulfate results in increased expression of CLIP2 mRNA

NCBI chr 5:134,518,237...134,582,922
Ensembl chr 5:134,518,237...134,581,288

G

clathrin light chain B

decreases expression
increases expression

nickel sulfate results in decreased expression of CLTB mRNA
nickel sulfate results in increased expression of CLTB mRNA

PMID:16780908 PMID:18651567

NCBI chr13:54,740,199...54,759,186
Ensembl chr13:54,740,214...54,759,157

G

carboxymethylenebutenolidase homolog

increases expression

nickel sulfate results in increased expression of CMBL mRNA

NCBI chr15:31,565,314...31,590,266
Ensembl chr15:31,565,535...31,590,265

G

c-Maf inducing protein

increases expression

nickel sulfate results in increased expression of CMIP mRNA

NCBI chr 8:117,983,758...118,188,245
Ensembl chr 8:117,983,803...118,186,169

G

cytidine/uridine monophosphate kinase 2

decreases expression

nickel sulfate results in decreased expression of CMPK2 mRNA

NCBI chr12:26,519,121...26,529,836
Ensembl chr12:26,519,203...26,529,836

G

calponin 1

decreases expression

nickel sulfate results in decreased expression of CNN1 mRNA

NCBI chr 9:22,010,501...22,020,517
Ensembl chr 9:22,010,512...22,020,926

G

cyclin M1

decreases expression

nickel sulfate results in decreased expression of CNNM1 mRNA

NCBI chr19:43,427,508...43,485,649
Ensembl chr19:43,428,875...43,485,649

G

contactin associated protein-like 1

decreases expression

nickel sulfate results in decreased expression of CNTNAP1 mRNA

NCBI chr11:101,065,429...101,081,550
Ensembl chr11:101,061,349...101,081,550

G

contactin associated protein-like 3

increases expression

nickel sulfate results in increased expression of CNTNAP3 mRNA

NCBI chr13:64,883,994...65,051,845
Ensembl chr13:64,883,996...65,051,769

G

cochlin

decreases expression

nickel sulfate results in decreased expression of COCH mRNA

NCBI chr12:51,640,156...51,652,558
Ensembl chr12:51,640,124...51,652,554

G

collagen, type XII, alpha 1

decreases expression

nickel sulfate results in decreased expression of COL12A1 mRNA

NCBI chr 9:79,506,269...79,628,423
Ensembl chr 9:79,506,273...79,626,113

G

collagen, type XV, alpha 1

decreases expression

nickel sulfate results in decreased expression of COL15A1 mRNA

NCBI chr 4:47,207,744...47,313,165
Ensembl chr 4:47,208,161...47,313,167

G

collagen, type XVI, alpha 1

increases expression

nickel sulfate results in increased expression of COL16A1 mRNA

NCBI chr 4:129,941,638...129,993,070
Ensembl chr 4:129,941,633...129,993,076

G

collagen, type I, alpha 1

decreases expression

nickel sulfate results in decreased expression of COL1A1 mRNA

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type III, alpha 1

decreases expression

nickel sulfate results in decreased expression of COL3A1 mRNA

NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866

G

collagen, type IV, alpha 1

decreases expression

nickel sulfate results in decreased expression of COL4A1 mRNA

NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826

G

collagen, type IV, alpha 4

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of COL4A4 mRNA

NCBI chr 1:82,426,140...82,564,570
Ensembl chr 1:82,426,144...82,564,570

G

collagen, type IV, alpha 5

decreases expression

nickel sulfate results in decreased expression of COL4A5 mRNA

NCBI chr X:140,258,367...140,472,232
Ensembl chr X:140,258,381...140,472,230

G

collagen, type V, alpha 1

decreases expression

nickel sulfate results in decreased expression of COL5A1 mRNA

NCBI chr 2:27,776,393...27,929,522
Ensembl chr 2:27,776,437...27,929,526

G

collagen, type V, alpha 2

increases expression

nickel sulfate results in increased expression of COL5A2 mRNA

NCBI chr 1:45,413,491...45,542,442
Ensembl chr 1:45,413,481...45,542,442

G

collagen, type VI, alpha 3

decreases expression

nickel sulfate results in decreased expression of COL6A3 mRNA

NCBI chr 1:90,694,582...90,771,710
Ensembl chr 1:90,693,645...90,771,693

G

collagen, type VIII, alpha 1

decreases expression

nickel sulfate results in decreased expression of COL8A1 mRNA

NCBI chr16:57,444,619...57,575,100
Ensembl chr16:57,444,621...57,575,100

G

COMM domain containing 3

decreases expression

nickel sulfate results in decreased expression of COMMD3 mRNA

NCBI chr 2:18,677,246...18,681,042
Ensembl chr 2:18,677,234...18,681,042

G

catechol-O-methyltransferase

increases expression

nickel sulfate results in increased expression of COMT mRNA

NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602

G

coronin, actin binding protein, 2B

decreases expression

nickel sulfate results in decreased expression of CORO2B mRNA

NCBI chr 9:62,326,770...62,444,326
Ensembl chr 9:62,326,774...62,444,326

G

carboxypeptidase E

decreases expression

nickel sulfate results in decreased expression of CPE mRNA

NCBI chr 8:65,045,576...65,146,143
Ensembl chr 8:65,045,576...65,146,088

G

cytoplasmic polyadenylation element binding protein 3

decreases expression

nickel sulfate results in decreased expression of CPEB3 mRNA

NCBI chr19:36,996,742...37,185,018
Ensembl chr19:36,998,691...37,186,000

G

copine III

decreases expression

nickel sulfate results in decreased expression of CPNE3 mRNA

NCBI chr 4:19,519,252...19,570,108
Ensembl chr 4:19,519,254...19,570,108

G

calcineurin-like phosphoesterase domain containing 1

increases expression

nickel sulfate results in increased expression of CPPED1 mRNA

NCBI chr16:11,621,546...11,727,377
Ensembl chr16:11,621,585...11,727,309

G

carboxypeptidase Q

increases expression

nickel sulfate results in increased expression of PGCP mRNA

NCBI chr15:33,083,275...33,594,698
Ensembl chr15:33,083,275...33,594,698

G

carnitine palmitoyltransferase 1c

decreases expression

nickel sulfate results in decreased expression of CPT1C mRNA

NCBI chr 7:44,607,907...44,624,304
Ensembl chr 7:44,608,796...44,624,275

G

carboxypeptidase, vitellogenic-like

increases expression

nickel sulfate results in increased expression of CPVL mRNA

NCBI chr 6:53,850,106...53,955,658
Ensembl chr 6:53,850,264...53,955,656

G

cellular retinoic acid binding protein II

decreases expression

nickel sulfate results in decreased expression of CRABP2 mRNA

NCBI chr 3:87,856,000...87,860,679
Ensembl chr 3:87,855,973...87,860,683

G

cAMP responsive element binding protein 1

affects expression
multiple interactions
increases phosphorylation

nickel sulfate affects the expression of CREB1 mRNA
[nickel sulfate co-treated with Dinoprostone] results in increased expression of CREB1 protein; CREB1 protein promotes the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]
nickel sulfate results in increased phosphorylation of CREB1 protein
puerarin inhibits the reaction [nickel sulfate results in increased phosphorylation of CREB1 protein]

PMID:20385217 PMID:23526216 PMID:26607348

NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707

G

cAMP responsive element binding protein 5

decreases expression

nickel sulfate results in decreased expression of CREB5 mRNA

NCBI chr 6:53,264,154...53,677,349
Ensembl chr 6:53,264,255...53,677,361

G

cAMP responsive element modulator

increases expression

nickel sulfate results in increased expression of CREM mRNA

PMID:16780908 PMID:17374397

NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748

G

cysteine rich transmembrane BMP regulator 1

increases expression

nickel sulfate results in increased expression of CRIM1 mRNA

NCBI chr17:78,507,602...78,684,021
Ensembl chr17:78,507,677...78,684,021

G

cardiolipin synthase 1

decreases expression

nickel sulfate results in decreased expression of CRLS1 mRNA

NCBI chr 2:132,688,557...132,708,706
Ensembl chr 2:132,688,586...132,708,705

G

crooked neck pre-mRNA splicing factor 1

decreases expression

nickel sulfate results in decreased expression of CRNKL1 mRNA

NCBI chr 2:145,759,402...145,776,620
Ensembl chr 2:145,759,399...145,776,934

G

beta-gamma crystallin domain containing 3

decreases expression

nickel sulfate results in decreased expression of CRYBG3 mRNA

NCBI chr16:59,312,451...59,421,410
Ensembl chr16:59,311,138...59,421,342

G

colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)

affects expression

nickel sulfate affects the expression of CSF2RB mRNA

NCBI chr15:78,166,707...78,189,921
Ensembl chr15:78,166,707...78,189,921

G

colony stimulating factor 3 receptor

increases expression

nickel sulfate results in increased expression of CSF3R mRNA

NCBI chr 4:125,917,241...125,938,233
Ensembl chr 4:125,918,343...125,938,233

G

casein kinase 2, alpha 1 polypeptide

decreases expression

nickel sulfate results in decreased expression of CSNK2A1 mRNA

NCBI chr 2:152,068,468...152,123,772
Ensembl chr 2:152,068,759...152,123,772

G

chondroitin sulfate proteoglycan 4

decreases expression

nickel sulfate results in decreased expression of CSPG4 mRNA

NCBI chr 9:56,772,388...56,807,154
Ensembl chr 9:56,772,317...56,807,154

G

cystatin A family member 2

decreases expression

nickel sulfate results in decreased expression of CSTA mRNA

NCBI chr16:36,041,932...36,077,813
Ensembl chr16:36,041,838...36,077,810

G

cystathionine gamma lyase

decreases expression

nickel sulfate results in decreased expression of CTH mRNA

NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714

G

catenin alpha like 1

decreases expression

nickel sulfate results in decreased expression of CTNNAL1 mRNA

NCBI chr 4:56,810,935...56,865,370
Ensembl chr 4:56,810,935...56,865,188

G

cytidine 5'-triphosphate synthase 1

increases expression

nickel sulfate results in increased expression of CTPS1 mRNA

NCBI chr 4:120,397,065...120,427,473
Ensembl chr 4:120,397,065...120,427,473

G

cathepsin B

increases expression

nickel sulfate results in increased expression of CTSB mRNA

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

cathepsin C

decreases expression

nickel sulfate results in decreased expression of CTSC mRNA

PMID:16780908 PMID:17374397 PMID:22714537 PMID:25673294

NCBI chr 7:87,927,233...87,960,083
Ensembl chr 7:87,927,293...87,960,096

G

cathepsin F

decreases expression

nickel sulfate results in decreased expression of CTSF mRNA

NCBI chr19:4,905,153...4,910,946
Ensembl chr19:4,905,158...4,910,946

G

cathepsin L

increases expression
decreases expression

nickel sulfate results in increased expression of CTSL mRNA
nickel sulfate results in decreased expression of CTSL mRNA

PMID:16780908 PMID:17374397

NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704

G

cullin 4B

decreases expression

nickel sulfate results in decreased expression of CUL4B mRNA

NCBI chr X:37,620,493...37,665,073
Ensembl chr X:37,622,151...37,665,073

G

coxsackie virus and adenovirus receptor

decreases expression

nickel sulfate results in decreased expression of CXADR mRNA

NCBI chr16:78,098,114...78,156,673
Ensembl chr16:78,098,377...78,156,662

G

C-X-C motif chemokine ligand 1

multiple interactions
increases expression

HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL1 protein]; macrophage stimulatory lipopeptide 2 promotes the reaction [nickel sulfate results in increased expression of CXCL1 mRNA]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of CXCL1 mRNA]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased secretion of CXCL1 protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of CXCL1 protein]

PMID:16780908 PMID:18832182

NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974

G

C-X-C motif chemokine ligand 10

increases expression
multiple interactions
decreases expression

nickel sulfate results in increased expression of CXCL10 mRNA
[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of CXCL10 mRNA; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [nickel sulfate inhibits the reaction [macrophage stimulatory lipopeptide 2 results in increased secretion of CXCL10 protein]]; nickel sulfate inhibits the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of CXCL10 mRNA]; nickel sulfate inhibits the reaction [macrophage stimulatory lipopeptide 2 results in increased secretion of CXCL10 protein]
nickel sulfate results in decreased expression of CXCL10 mRNA

PMID:12060402 PMID:18096868 PMID:18832182 PMID:23445166

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

C-X-C motif chemokine ligand 15

multiple interactions
increases expression
affects expression
increases secretion
decreases expression

6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]; [[Dinoprostone results in increased activity of PTGER2 protein] which results in increased susceptibility to nickel sulfate] which results in increased secretion of CXCL8 protein; [[Dinoprostone results in increased activity of PTGER4 protein] which results in increased susceptibility to nickel sulfate] which results in increased secretion of CXCL8 protein; [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of CXCL8 mRNA; [nickel sulfate co-treated with butaprost] results in increased secretion of CXCL8 protein; [nickel sulfate co-treated with Colforsin] results in increased secretion of CXCL8 protein; [nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein; [nickel sulfate co-treated with lipopolysaccharide, E. coli O26-B6] results in decreased expression of CXCL8 mRNA; [nickel sulfate co-treated with TR4161] results in increased secretion of CXCL8 protein; [Tetradecanoylphorbol Acetate co-treated with nickel sulfate] results in increased expression of and results in increased secretion of CXCL8 protein; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CXCL8 mRNA]; BAY 11-7085 inhibits the reaction [nickel sulfate results in increased secretion of CXCL8 protein]; CREB1 protein promotes the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]; ferric chloride inhibits the reaction [nickel sulfate results in increased expression of CXCL8 protein]; ferrous sulfate inhibits the reaction [nickel sulfate results in increased expression of CXCL8 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL8 protein]; HIF1A protein promotes the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]; IL1A protein affects the reaction [nickel sulfate results in increased secretion of CXCL8 protein]; L-161982 inhibits the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased secretion of CXCL8 protein]]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of CXCL8 mRNA]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased secretion of CXCL8 protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of CXCL8 protein]; SB 203580 affects the reaction [nickel sulfate results in increased secretion of CXCL8 protein]; SB 203580 inhibits the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]; TNF protein affects the reaction [nickel sulfate results in increased secretion of CXCL8 protein]
nickel sulfate results in increased expression of CXCL8 mRNA; nickel sulfate results in increased expression of CXCL8 protein
nickel sulfate affects the expression of CXCL8 mRNA
nickel sulfate results in decreased expression of CXCL8 mRNA

PMID:11978798 PMID:12781210 PMID:15020194 PMID:15081272 PMID:15679580 More...

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

C-X-C motif chemokine ligand 16

increases expression

nickel sulfate results in increased expression of CXCL16 mRNA

NCBI chr11:70,345,215...70,350,810
Ensembl chr11:70,344,809...70,350,810

G

C-X-C motif chemokine ligand 2

affects expression
increases expression

nickel sulfate affects the expression of CXCL2 mRNA
nickel sulfate results in increased expression of CXCL2 mRNA

PMID:11708899 PMID:18202158

NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797

G

C-X-C motif chemokine ligand 3

multiple interactions
increases expression

HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL1 protein]; macrophage stimulatory lipopeptide 2 promotes the reaction [nickel sulfate results in increased expression of CXCL1 mRNA]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of CXCL1 mRNA]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased secretion of CXCL1 protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of CXCL1 protein]

PMID:16166746 PMID:16780908 PMID:18832182

NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459

G

C-X-C motif chemokine ligand 5

multiple interactions

nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of CXCL6 mRNA]

NCBI chr 5:90,907,157...90,909,484
Ensembl chr 5:90,907,219...90,909,483

G

C-X-C motif chemokine receptor 4

decreases expression
affects expression
increases expression

nickel sulfate results in decreased expression of CXCR4 protein
nickel sulfate affects the expression of CXCR4 mRNA
nickel sulfate results in increased expression of CXCR4 mRNA

PMID:15924226 PMID:16780908 PMID:17374397 PMID:17382205 PMID:18202158

NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030

G

cytochrome b-245, alpha polypeptide

increases expression

nickel sulfate results in increased expression of CYBA mRNA

NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669

G

cytochrome c, somatic

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CYCS mRNA]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CYCS protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CYCS mRNA]
nickel sulfate results in increased expression of CYCS mRNA; nickel sulfate results in increased expression of CYCS protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CYCS protein]]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CYCS protein]

PMID:28296042 PMID:34612572

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

cytoglobin

decreases expression

nickel sulfate results in decreased expression of CYGB mRNA

NCBI chr11:116,536,421...116,544,887
Ensembl chr11:116,536,421...116,545,139

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression
multiple interactions

nickel sulfate results in decreased expression of CYP11A1 mRNA; nickel sulfate results in decreased expression of CYP11A1 protein
[CGA protein co-treated with nickel sulfate] results in decreased expression of CYP11A1 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP11A1 protein; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]

NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression
multiple interactions

nickel sulfate results in decreased expression of CYP17A1 mRNA; nickel sulfate results in decreased expression of CYP17A1 protein
[CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 protein; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]

NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
decreases expression

nickel sulfate results in increased expression of CYP1A1 mRNA
nickel sulfate results in decreased expression of CYP1A1 mRNA

PMID:20491607 PMID:20713136

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases expression
multiple interactions

nickel sulfate results in decreased expression of CYP1B1 mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of CYP1B1 mRNA

PMID:22714537 PMID:31734292

NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression
increases expression
multiple interactions

nickel sulfate results in decreased expression of CYP27A1 mRNA
nickel sulfate results in increased expression of CYP27A1 mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of CYP27A1 mRNA

PMID:20713136 PMID:22714537 PMID:31734292

NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051

G

cytochrome P450, family 2, subfamily b, polypeptide 10

decreases expression

nickel sulfate results in decreased expression of CYP2B10 mRNA

NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049

G

cytochrome P450, family 2, subfamily b, polypeptide 9

decreases expression

nickel sulfate results in decreased expression of CYP2B9 mRNA

NCBI chr 7:25,872,775...25,910,086
Ensembl chr 7:25,872,836...25,910,086

G

cytochrome P450, family 2, subfamily f, polypeptide 2

affects expression
decreases expression

nickel sulfate affects the expression of CYP2F2 mRNA
nickel sulfate results in decreased expression of CYP2F2 mRNA

PMID:12718980 PMID:16100012

NCBI chr 7:26,819,380...26,833,085
Ensembl chr 7:26,819,334...26,833,085

G

cytochrome P450, family 2, subfamily u, polypeptide 1

decreases expression

nickel sulfate results in decreased expression of CYP2U1 mRNA

NCBI chr 3:131,084,140...131,097,806
Ensembl chr 3:131,082,090...131,096,876

G

cytohesin 1 interacting protein

increases expression

nickel sulfate results in increased expression of CYTIP mRNA

NCBI chr 2:58,019,151...58,085,559
Ensembl chr 2:58,019,149...58,085,544

G

DNA segment, Chr 17, human D6S53E

increases expression

nickel sulfate results in increased expression of C6ORF47 mRNA

NCBI chr17:35,345,378...35,347,831
Ensembl chr17:35,345,349...35,347,831

G

disabled 1

increases expression

nickel sulfate results in increased expression of DAB1 mRNA

NCBI chr 4:103,476,425...104,602,041
Ensembl chr 4:103,476,556...104,602,041

G

dishevelled-binding antagonist of beta-catenin 1

decreases expression

nickel sulfate results in decreased expression of DACT1 mRNA

NCBI chr12:71,356,658...71,366,881
Ensembl chr12:71,356,658...71,366,881

G

death associated protein kinase 1

decreases expression

nickel sulfate results in decreased expression of DAPK1 mRNA

NCBI chr13:60,749,506...60,911,005
Ensembl chr13:60,749,761...60,911,005

G

discoidin, CUB and LCCL domain containing 2

decreases expression

nickel sulfate results in decreased expression of DCBLD2 mRNA

NCBI chr16:58,228,789...58,304,013
Ensembl chr16:58,228,806...58,290,090

G

doublecortin-like kinase 2

increases expression

nickel sulfate results in increased expression of DCLK2 mRNA

NCBI chr 3:86,693,457...86,828,292
Ensembl chr 3:86,693,458...86,828,159

G

dopachrome tautomerase

increases expression

nickel sulfate results in increased expression of DCT mRNA

NCBI chr14:118,250,202...118,289,658
Ensembl chr14:118,250,202...118,289,656

G

dCTP pyrophosphatase 1

decreases expression

nickel sulfate results in decreased expression of DCTPP1 mRNA

NCBI chr 7:126,856,131...126,859,839
Ensembl chr 7:126,856,131...126,859,881

G

DDAH family member 2, ADMA independent

increases expression

nickel sulfate results in increased expression of DDAH2 mRNA

NCBI chr17:35,278,011...35,281,075
Ensembl chr17:35,278,011...35,281,071

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

nickel sulfate results in increased expression of DDIT3 mRNA; nickel sulfate results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of DDIT3 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of DDIT3 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of DDIT3 protein]

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

DNA-damage-inducible transcript 4

increases expression

nickel sulfate results in increased expression of DDIT4 mRNA

NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656

G

D-aspartate oxidase

increases expression

nickel sulfate results in increased expression of DDO mRNA

NCBI chr10:40,505,933...40,557,847
Ensembl chr10:40,506,007...40,557,843

G

discoidin domain receptor family, member 1

increases expression

nickel sulfate results in increased expression of DDR1 mRNA

NCBI chr17:35,992,459...36,015,633
Ensembl chr17:35,992,459...36,015,513

G

discoidin domain receptor family, member 2

increases expression

nickel sulfate results in increased expression of DDR2 mRNA

NCBI chr 1:169,799,874...169,938,525
Ensembl chr 1:169,799,876...169,938,331

G

DDRGK domain containing 1

decreases expression

nickel sulfate results in decreased expression of DDRGK1 mRNA

NCBI chr 2:130,495,955...130,506,549
Ensembl chr 2:130,495,880...130,506,579

G

DEAD box helicase 17

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of DDX17 mRNA

NCBI chr15:79,411,897...79,430,976
Ensembl chr15:79,411,937...79,430,942

G

DEAD box helicase 39b

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of DDX39B mRNA

NCBI chr17:35,460,722...35,472,683
Ensembl chr17:35,460,722...35,472,683

G

DEAF1, transcription factor

increases expression

nickel sulfate results in increased expression of DEAF1 mRNA

NCBI chr 7:140,877,089...140,918,758
Ensembl chr 7:140,877,093...140,907,603

G

differentially expressed in FDCP 8

increases expression

nickel sulfate results in increased expression of DEF8 mRNA

NCBI chr 8:124,169,725...124,190,009
Ensembl chr 8:124,150,266...124,190,009

G

DENN domain containing 1B

increases expression

nickel sulfate results in increased expression of DENND1B mRNA

NCBI chr 1:138,891,447...139,103,781
Ensembl chr 1:138,891,173...139,106,698

G

DENN domain containing 2D

decreases expression

nickel sulfate results in decreased expression of DENND2D mRNA

NCBI chr 3:106,389,745...106,410,346
Ensembl chr 3:106,389,721...106,410,346

G

DEPP1 autophagy regulator

increases expression

nickel sulfate results in increased expression of DEPP1 mRNA

PMID:16780908 PMID:17382205

NCBI chr 6:116,627,645...116,629,808
Ensembl chr 6:116,627,570...116,629,755

G

diacylglycerol kinase, alpha

decreases expression

nickel sulfate results in decreased expression of DGKA mRNA

NCBI chr10:128,556,000...128,581,002
Ensembl chr10:128,556,003...128,580,724

G

diacylglycerol kinase, eta

decreases expression

nickel sulfate results in decreased expression of DGKH mRNA

NCBI chr14:78,796,789...78,970,169
Ensembl chr14:78,796,190...78,970,216

G

diacylglycerol kinase, iota

decreases expression

nickel sulfate results in decreased expression of DGKI mRNA

NCBI chr 6:36,814,316...37,281,034
Ensembl chr 6:36,822,957...37,277,119

G

dehydrogenase/reductase 11

increases expression

nickel sulfate results in increased expression of DHRS11 mRNA

NCBI chr11:84,711,547...84,719,880
Ensembl chr11:84,711,682...84,719,820

G

diaphanous related formin 2

decreases expression

nickel sulfate results in decreased expression of DIAPH2 mRNA

NCBI chr X:128,650,409...129,366,583
Ensembl chr X:128,650,491...129,366,583

G

deiodinase, iodothyronine, type II

increases expression

nickel sulfate results in increased expression of DIO2 mRNA

NCBI chr12:90,691,326...90,705,812
Ensembl chr12:90,691,326...90,705,812

G

dyskeratosis congenita 1, dyskerin

decreases expression

nickel sulfate results in decreased expression of DKC1 mRNA

PMID:16780908 PMID:17374397

NCBI chr X:74,139,460...74,153,382
Ensembl chr X:74,139,460...74,153,383

G

distal-less homeobox 1

increases expression

nickel sulfate results in increased expression of DLX1 mRNA

NCBI chr 2:71,358,457...71,364,325
Ensembl chr 2:71,358,457...71,364,325

G

distal-less homeobox 2

increases expression

nickel sulfate results in increased expression of DLX2 mRNA

NCBI chr 2:71,373,752...71,377,095
Ensembl chr 2:71,373,752...71,377,098

G

dynein axonemal assembly factor 9

decreases expression

nickel sulfate results in decreased expression of DNAAF9 mRNA

NCBI chr 2:130,548,120...130,682,565
Ensembl chr 2:130,548,120...130,748,326

G

dynein, axonemal, heavy chain 11

increases expression

nickel sulfate results in increased expression of DNAH11 mRNA

NCBI chr12:117,841,717...118,162,778
Ensembl chr12:117,841,717...118,162,778

G

dynein, axonemal, heavy chain 9

decreases expression

nickel sulfate results in decreased expression of DNAH9 mRNA

NCBI chr11:65,722,150...66,059,379
Ensembl chr11:65,722,108...66,059,377

G

DnaJ heat shock protein family (Hsp40) member A4

decreases expression

nickel sulfate results in decreased expression of DNAJA4 mRNA

NCBI chr 9:54,606,132...54,623,601
Ensembl chr 9:54,606,157...54,623,599

G

DnaJ heat shock protein family (Hsp40) member B6

increases expression

nickel sulfate results in increased expression of DNAJB6 mRNA

NCBI chr 5:29,940,896...29,991,476
Ensembl chr 5:29,940,686...30,023,132

G

DnaJ heat shock protein family (Hsp40) member C1

decreases expression

nickel sulfate results in decreased expression of DNAJC1 mRNA

NCBI chr 2:18,210,445...18,402,025
Ensembl chr 2:18,200,465...18,397,641

G

dynein, axonemal, light intermediate polypeptide 1

decreases expression

nickel sulfate results in decreased expression of DNALI1 mRNA

NCBI chr 4:124,949,131...124,959,443
Ensembl chr 4:124,949,131...124,959,496

G

dynamin 3

decreases expression

nickel sulfate results in decreased expression of DNM3 mRNA

NCBI chr 1:161,810,022...162,305,890
Ensembl chr 1:161,810,022...162,305,603

G

dedicator of cytokinesis 10

increases expression

nickel sulfate results in increased expression of DOCK10 mRNA

NCBI chr 1:80,478,785...80,736,482
Ensembl chr 1:80,478,790...80,736,244

G

dedicator of cytokinesis 11

increases expression

nickel sulfate results in increased expression of DOCK11 mRNA

NCBI chr X:35,150,924...35,340,223
Ensembl chr X:35,152,485...35,340,215

G

dipeptidylpeptidase 4

decreases expression
increases expression

nickel sulfate results in decreased expression of DPP4 mRNA
nickel sulfate results in increased expression of DPP4 mRNA

PMID:16780908 PMID:22714537

NCBI chr 2:62,160,417...62,242,635
Ensembl chr 2:62,160,417...62,242,575

G

dipeptidylpeptidase 7

decreases expression

nickel sulfate results in decreased expression of DPP7 mRNA

NCBI chr 2:25,242,302...25,246,365
Ensembl chr 2:25,242,288...25,246,371

G

dpy-19 like C-mannosyltransferase 3

decreases expression

nickel sulfate results in decreased expression of DPY19L3 mRNA

NCBI chr 7:35,384,925...35,453,879
Ensembl chr 7:35,384,590...35,453,879

G

dihydropyrimidine dehydrogenase

decreases expression

nickel sulfate results in decreased expression of DPYD mRNA

NCBI chr 3:118,355,758...119,226,573
Ensembl chr 3:118,355,778...119,226,573

G

DNA-damage regulated autophagy modulator 1

increases expression

nickel sulfate results in increased expression of DRAM1 mRNA

NCBI chr10:88,158,663...88,200,218
Ensembl chr10:88,158,666...88,214,942

G

dermatan sulfate epimerase

decreases expression

nickel sulfate results in decreased expression of DSE mRNA

NCBI chr10:34,027,385...34,084,267
Ensembl chr10:34,027,389...34,083,711

G

dermatan sulfate epimerase-like

increases expression

nickel sulfate results in increased expression of DSEL mRNA

NCBI chr 1:111,786,431...111,792,782
Ensembl chr 1:111,786,432...111,792,648

G

desmoglein 2

increases expression

nickel sulfate results in increased expression of DSG2 mRNA

PMID:16780908 PMID:22714537

NCBI chr18:20,691,247...20,737,583
Ensembl chr18:20,691,131...20,737,578

G

destrin

decreases expression

nickel sulfate results in decreased expression of DSTN mRNA

NCBI chr 2:143,757,251...143,785,244
Ensembl chr 2:143,757,240...143,785,244

G

D-tyrosyl-tRNA deacylase 1

decreases expression

nickel sulfate results in decreased expression of DTD1 mRNA

NCBI chr 2:144,441,873...144,610,667
Ensembl chr 2:144,441,817...144,610,678

G

deltex 3, E3 ubiquitin ligase

decreases expression

nickel sulfate results in decreased expression of DTX3 mRNA

NCBI chr10:127,026,242...127,032,367
Ensembl chr10:127,026,247...127,031,597

G

dual specificity phosphatase 1

increases expression

nickel sulfate results in increased expression of DUSP1 mRNA

NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102

G

dual specificity phosphatase 10

increases expression

nickel sulfate results in increased expression of DUSP10 mRNA

NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833

G

dual specificity phosphatase 22

increases expression

nickel sulfate results in increased expression of DUSP22 mRNA

NCBI chr13:30,844,042...30,895,215
Ensembl chr13:30,843,982...30,895,214

G

dual specificity phosphatase 23

decreases expression

nickel sulfate results in decreased expression of DUSP23 mRNA

NCBI chr 1:172,458,336...172,460,504
Ensembl chr 1:172,458,331...172,460,529

G

dual specificity phosphatase 4

increases expression

nickel sulfate results in increased expression of DUSP4 mRNA

NCBI chr 8:35,274,448...35,289,106
Ensembl chr 8:35,274,451...35,287,048

G

dual specificity phosphatase 5

increases expression

nickel sulfate results in increased expression of DUSP5 mRNA

NCBI chr19:53,517,576...53,530,240
Ensembl chr19:53,517,540...53,530,862

G

dynein cytoplasmic 2 heavy chain 1

decreases expression

nickel sulfate results in decreased expression of DYNC2H1 mRNA

NCBI chr 9:6,928,550...7,177,619
Ensembl chr 9:6,928,503...7,184,446

G

dysferlin

decreases expression

nickel sulfate results in decreased expression of DYSF mRNA

NCBI chr 6:83,985,344...84,188,042
Ensembl chr 6:83,985,572...84,188,042

G

eosinophil-associated, ribonuclease A family, member 2

decreases expression

nickel sulfate results in decreased expression of EAR2 mRNA

NCBI chr14:44,340,111...44,340,988
Ensembl chr14:44,340,111...44,340,991

G

Epstein-Barr virus induced gene 3

increases expression
multiple interactions

nickel sulfate results in increased expression of EBI3 mRNA
BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of EBI3 mRNA]; TLR4 protein affects the reaction [nickel sulfate results in increased expression of EBI3 mRNA]

PMID:16780908 PMID:30421605

NCBI chr17:56,259,623...56,264,022
Ensembl chr17:56,259,640...56,264,022

G

endothelin converting enzyme 1

increases expression

nickel sulfate results in increased expression of ECE1 mRNA

NCBI chr 4:137,589,548...137,692,540
Ensembl chr 4:137,589,548...137,692,540

G

enoyl Coenzyme A hydratase domain containing 3

decreases expression

nickel sulfate results in decreased expression of ECHDC3 mRNA

NCBI chr 2:6,193,276...6,217,805
Ensembl chr 2:6,193,276...6,217,844

G

extracellular matrix protein 1

increases expression

nickel sulfate results in increased expression of ECM1 mRNA

NCBI chr 3:95,641,459...95,646,880
Ensembl chr 3:95,641,459...95,646,881

G

EDAR associated via death domain

increases expression

nickel sulfate results in increased expression of EDARADD mRNA

NCBI chr13:12,486,090...12,535,413
Ensembl chr13:12,487,513...12,535,319

G

ER degradation enhancer, mannosidase alpha-like 3

decreases expression

nickel sulfate results in decreased expression of EDEM3 mRNA

NCBI chr 1:151,631,099...151,698,079
Ensembl chr 1:151,631,122...151,697,802

G

EGF-like repeats and discoidin I-like domains 3

decreases expression

nickel sulfate results in decreased expression of EDIL3 mRNA

NCBI chr13:88,969,591...89,471,344
Ensembl chr13:88,969,591...89,471,342

G

endothelin 1

increases expression

nickel sulfate results in increased expression of EDN1 mRNA

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

epidermal growth factor-containing fibulin-like extracellular matrix protein 2

decreases expression

nickel sulfate results in decreased expression of EFEMP2 mRNA

NCBI chr19:5,523,974...5,532,548
Ensembl chr19:5,523,982...5,532,545

G

EF-hand domain (C-terminal) containing 1

increases expression

nickel sulfate results in increased expression of EFHC1 mRNA

NCBI chr 1:21,021,776...21,061,065
Ensembl chr 1:21,021,850...21,061,065

G

ephrin A1

multiple interactions
increases expression

[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of EFNA1 mRNA
nickel sulfate results in increased expression of EFNA1 mRNA

PMID:18651567 PMID:18832182

NCBI chr 3:89,179,037...89,188,258
Ensembl chr 3:89,179,040...89,188,449

G

ephrin A3

increases expression
multiple interactions

nickel sulfate results in increased expression of EFNA3 mRNA
[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of EFNA3 mRNA

NCBI chr 3:89,221,200...89,231,359
Ensembl chr 3:89,221,206...89,230,272

G

ephrin A5

decreases expression

nickel sulfate results in decreased expression of EFNA5 mRNA

NCBI chr17:62,909,949...63,188,431
Ensembl chr17:62,911,179...63,188,312

G

epidermal growth factor receptor

multiple interactions

[TGFA protein binds to and affects the activity of EGFR protein] which results in decreased susceptibility to nickel sulfate

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

early growth response 1

increases expression

nickel sulfate results in increased expression of EGR1 mRNA

NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037

G

enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase

increases expression

nickel sulfate results in increased expression of EHHADH mRNA

PMID:17374397 PMID:22714537

NCBI chr16:21,580,035...21,606,589
Ensembl chr16:21,580,037...21,606,557

G

euchromatic histone lysine N-methyltransferase 2

increases expression

nickel sulfate results in increased expression of EHMT2 mRNA

NCBI chr17:35,117,427...35,133,049
Ensembl chr17:35,117,445...35,133,028

G

etoposide induced 2.4 mRNA

decreases expression

nickel sulfate results in decreased expression of EI24 mRNA

NCBI chr 9:36,690,449...36,708,630
Ensembl chr 9:36,690,455...36,708,689

G

eukaryotic translation initiation factor 1A, X-linked

decreases expression

nickel sulfate results in decreased expression of EIF1A mRNA

NCBI chr X:158,155,174...158,172,617
Ensembl chr X:158,155,174...158,172,924

G

eukaryotic translation initiation factor 4, gamma 1

increases expression

nickel sulfate results in increased expression of EIF4G1 mRNA

NCBI chr16:20,491,457...20,511,633
Ensembl chr16:20,487,063...20,511,634

G

elastin

increases expression

nickel sulfate results in increased expression of ELN mRNA

NCBI chr 5:134,731,449...134,776,300
Ensembl chr 5:134,731,447...134,776,177

G

ELOVL fatty acid elongase 2

increases expression

nickel sulfate results in increased expression of ELOVL2 mRNA

NCBI chr13:41,335,858...41,373,879
Ensembl chr13:41,335,857...41,373,881

G

ELOVL fatty acid elongase 3

multiple interactions

[nickel sulfate co-treated with Particulate Matter] results in decreased expression of ELOVL3 mRNA

NCBI chr19:46,120,336...46,124,133
Ensembl chr19:46,120,336...46,124,133

G

ELOVL fatty acid elongase 7

increases expression

nickel sulfate results in increased expression of ELOVL7 mRNA

NCBI chr13:108,350,860...108,423,643
Ensembl chr13:108,350,938...108,422,217

G

embigin

decreases expression

nickel sulfate results in decreased expression of EMB mRNA

NCBI chr13:117,357,109...117,410,951
Ensembl chr13:117,345,072...117,410,951

G

ER membrane protein complex subunit 8

increases expression

nickel sulfate results in increased expression of EMC8 mRNA

NCBI chr 8:121,380,653...121,394,826
Ensembl chr 8:121,380,653...121,395,312

G

echinoderm microtubule associated protein like 1

increases expression

nickel sulfate results in increased expression of EML1 mRNA

NCBI chr12:108,337,265...108,505,835
Ensembl chr12:108,337,216...108,505,876

G

epithelial membrane protein 1

decreases expression

nickel sulfate results in decreased expression of EMP1 mRNA

NCBI chr 6:135,339,548...135,360,171
Ensembl chr 6:135,339,543...135,360,171

G

ectodermal-neural cortex 1

decreases expression

nickel sulfate results in decreased expression of ENC1 mRNA

NCBI chr13:97,377,613...97,389,548
Ensembl chr13:97,377,613...97,389,542

G

endonuclease domain containing 1

decreases expression

nickel sulfate results in decreased expression of ENDOD1 mRNA

NCBI chr 9:14,265,286...14,292,538
Ensembl chr 9:14,265,286...14,292,803

G

enolase 1, alpha non-neuron

increases expression

nickel sulfate results in increased expression of ENO1 mRNA

NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336
Ensembl chr18:150,321,178...150,333,336

G

enolase 2, gamma neuronal

increases expression

nickel sulfate results in increased expression of ENO2 mRNA

NCBI chr 6:124,737,018...124,746,489
Ensembl chr 6:124,737,016...124,746,636

G

enolase 3, beta muscle

affects expression

nickel sulfate affects the expression of ENO3 mRNA

NCBI chr11:70,543,973...70,553,339
Ensembl chr11:70,548,028...70,553,339

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

increases expression

nickel sulfate results in increased expression of ENPP1 mRNA

NCBI chr10:24,513,812...24,588,057
Ensembl chr10:24,513,812...24,588,057

G

ectonucleotide pyrophosphatase/phosphodiesterase 4

decreases expression

nickel sulfate results in decreased expression of ENPP4 mRNA

NCBI chr17:44,407,198...44,416,725
Ensembl chr17:44,407,199...44,416,700

G

ectonucleoside triphosphate diphosphohydrolase 1

increases expression

nickel sulfate results in increased expression of ENTPD1 mRNA

NCBI chr19:40,600,810...40,730,046
Ensembl chr19:40,600,810...40,730,046

G

ectonucleoside triphosphate diphosphohydrolase 6

decreases expression

nickel sulfate results in decreased expression of ENTPD6 mRNA

NCBI chr 2:150,590,959...150,613,595
Ensembl chr 2:150,590,962...150,613,595

G

endothelial PAS domain protein 1

multiple interactions
increases stability
increases expression

[HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in decreased expression of USP28 protein]; [HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in increased degradation of MYC protein]; Ascorbic Acid inhibits the reaction [nickel sulfate results in increased expression of EPAS1 protein]
nickel sulfate results in increased stability of EPAS1 protein
nickel sulfate results in increased expression of EPAS1 mRNA; nickel sulfate results in increased expression of EPAS1 protein

PMID:16288478 PMID:20046830 PMID:22714537

NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838

G

epithelial cell adhesion molecule

decreases expression

nickel sulfate results in decreased expression of EPCAM mRNA

NCBI chr17:87,943,407...87,958,555
Ensembl chr17:87,943,407...87,958,557

G

ependymin related 1

increases expression

nickel sulfate results in increased expression of EPDR1 mRNA

NCBI chr13:19,775,878...19,804,000
Ensembl chr13:19,775,876...19,804,097

G

Eph receptor A4

increases expression

nickel sulfate results in increased expression of EPHA4 mRNA

NCBI chr 1:77,343,819...77,491,763
Ensembl chr 1:77,343,822...77,491,725

G

Eph receptor B6

increases expression

nickel sulfate results in increased expression of EPHB6 mRNA

NCBI chr 6:41,581,940...41,597,445
Ensembl chr 6:41,582,416...41,597,443

G

EPM2A interacting protein 1

decreases expression

nickel sulfate results in decreased expression of EPM2AIP1 mRNA

NCBI chr 9:111,100,913...111,108,161
Ensembl chr 9:111,100,997...111,108,161

G

erb-b2 receptor tyrosine kinase 3

decreases expression

nickel sulfate results in decreased expression of ERBB3 mRNA

NCBI chr10:128,403,392...128,425,504
Ensembl chr10:128,403,392...128,425,521

G

esterase D/formylglutathione hydrolase

increases expression

nickel sulfate results in increased expression of ESD mRNA

NCBI chr14:74,969,591...74,988,205
Ensembl chr14:74,969,737...74,988,205

G

ESF1 nucleolar pre-rRNA processing protein homolog

decreases expression

nickel sulfate results in decreased expression of ESF1 mRNA

NCBI chr 2:139,961,800...140,012,498
Ensembl chr 2:139,961,803...140,012,484

G

enhancer trap locus 4

decreases expression

nickel sulfate results in decreased expression of KIAA1217 mRNA

NCBI chr 2:19,915,018...20,815,346
Ensembl chr 2:19,914,591...20,815,524

G

E26 avian leukemia oncogene 1, 5' domain

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of ETS1 mRNA

NCBI chr 9:32,547,501...32,669,116
Ensembl chr 9:32,547,517...32,669,116

G

E26 avian leukemia oncogene 2, 3' domain

increases expression

nickel sulfate results in increased expression of ETS2 mRNA

PMID:16780908 PMID:18651567

NCBI chr16:95,503,274...95,522,093
Ensembl chr16:95,502,942...95,522,095

G

ets variant 2

increases expression

nickel sulfate results in increased expression of ETV2 mRNA

NCBI chr 7:30,333,041...30,335,934
Ensembl chr 7:30,333,041...30,335,277

G

ets variant 6

increases expression

nickel sulfate results in increased expression of ETV6 mRNA

NCBI chr 6:134,012,663...134,247,121
Ensembl chr 6:134,012,663...134,247,121

G

eva-1 homolog C

increases expression

nickel sulfate results in increased expression of EVA1C mRNA

NCBI chr16:90,623,607...90,701,997
Ensembl chr16:90,623,607...90,701,997

G

ecotropic viral integration site 2b

increases expression

nickel sulfate results in increased expression of EVI2B mRNA

NCBI chr11:79,404,211...79,414,588
Ensembl chr11:79,405,882...79,414,588

G

exocyst complex component 2

increases expression

nickel sulfate results in increased expression of EXOC2 mRNA

NCBI chr13:30,968,421...31,162,082
Ensembl chr13:30,968,416...31,158,076

G

exocyst complex component 6

decreases expression

nickel sulfate results in decreased expression of EXOC6 mRNA

NCBI chr19:37,525,181...37,672,499
Ensembl chr19:37,509,327...37,672,507

G

exosome component 8

decreases expression

nickel sulfate results in decreased expression of EXOSC8 mRNA

NCBI chr 3:54,636,099...54,642,469
Ensembl chr 3:54,636,099...54,642,814

G

exophilin 5

decreases expression

nickel sulfate results in decreased expression of EXPH5 mRNA

NCBI chr 9:53,212,814...53,292,466
Ensembl chr 9:53,212,970...53,288,814

G

EYA transcriptional coactivator and phosphatase 1

decreases expression

nickel sulfate results in decreased expression of EYA1 mRNA

NCBI chr 1:14,239,177...14,381,259
Ensembl chr 1:14,239,178...14,380,459

G

EYA transcriptional coactivator and phosphatase 2

decreases expression

nickel sulfate results in decreased expression of EYA2 mRNA

NCBI chr 2:165,436,892...165,613,645
Ensembl chr 2:165,436,952...165,613,647

G

coagulation factor XIII, A1 subunit

decreases expression

nickel sulfate results in decreased expression of F13A1 mRNA

PMID:16780908 PMID:17374397

NCBI chr13:37,051,150...37,234,220
Ensembl chr13:37,051,152...37,234,220

G

coagulation factor II thrombin receptor like 2

decreases expression

nickel sulfate results in decreased expression of F2RL2 mRNA

NCBI chr13:95,833,428...95,839,276
Ensembl chr13:95,833,361...95,839,247

G

coagulation factor III

increases expression
decreases expression

nickel sulfate results in increased expression of F3 mRNA
nickel sulfate results in decreased expression of F3 mRNA

PMID:16100012 PMID:22714537

NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697

G

fatty acid binding protein 3, muscle and heart

increases expression
decreases expression

nickel sulfate results in increased expression of FABP3 mRNA
nickel sulfate results in decreased expression of FABP3 mRNA

PMID:17382205 PMID:22714537

NCBI chr 4:130,202,531...130,209,256
Ensembl chr 4:130,202,388...130,209,256

G

fatty acid binding protein 5, epidermal

increases expression
decreases expression

nickel sulfate results in increased expression of FABP5 mRNA
nickel sulfate results in decreased expression of FABP5 mRNA

PMID:16780908 PMID:18651567

NCBI chr 3:10,077,645...10,081,670
Ensembl chr 3:10,077,608...10,081,667

G

fumarylacetoacetate hydrolase domain containing 2A

increases expression

nickel sulfate results in increased expression of FAHD2A mRNA

NCBI chr 2:127,278,135...127,286,491
Ensembl chr 2:127,278,135...127,286,485

G

family with sequence similarity 117, member B

increases expression

nickel sulfate results in increased expression of FAM117B mRNA

NCBI chr 1:59,952,165...60,024,507
Ensembl chr 1:59,952,165...60,024,505

G

family with sequence similarity 120, member C

increases expression

nickel sulfate results in increased expression of FAM120C mRNA

NCBI chr X:150,125,515...150,257,135
Ensembl chr X:150,127,171...150,254,838

G

family with sequence similarity 162, member A

increases expression
decreases expression

nickel sulfate results in increased expression of FAM162A mRNA
nickel sulfate results in decreased expression of FAM162A mRNA

PMID:17382205 PMID:22714537

NCBI chr16:35,864,214...35,891,931
Ensembl chr16:35,864,131...35,891,964

G

family with sequence similarity 171, member B

increases expression

nickel sulfate results in increased expression of FAM171B mRNA

NCBI chr 2:83,642,889...83,713,878
Ensembl chr 2:83,642,980...83,713,830

G

family with sequence similarity 221, member A

decreases expression

nickel sulfate results in decreased expression of FAM221A mRNA

NCBI chr 6:49,343,855...49,366,839
Ensembl chr 6:49,344,673...49,367,473

G

FAM3 metabolism regulating signaling molecule C

decreases expression

nickel sulfate results in decreased expression of FAM3C mRNA

NCBI chr 6:22,306,519...22,356,080
Ensembl chr 6:22,306,519...22,356,242

G

family with sequence similarity 43, member A

increases expression

nickel sulfate results in increased expression of FAM43A mRNA

NCBI chr16:30,418,541...30,421,615
Ensembl chr16:30,418,541...30,421,615

G

family with sequence similarity 81, member A

increases expression

nickel sulfate results in increased expression of FAM81A mRNA

NCBI chr 9:69,996,586...70,049,840
Ensembl chr 9:69,995,793...70,049,842

G

Fanconi anemia, complementation group A

increases expression

nickel sulfate results in increased expression of FANCA mRNA

NCBI chr 8:123,993,033...124,045,390
Ensembl chr 8:123,995,039...124,045,315

G

FERM, ARH/RhoGEF and pleckstrin domain protein 1

increases expression

nickel sulfate results in increased expression of FARP1 mRNA

NCBI chr14:121,272,563...121,521,156
Ensembl chr14:121,272,612...121,521,156

G

phenylalanine-tRNA synthetase 2, mitochondrial

increases expression

nickel sulfate results in increased expression of FARS2 mRNA

NCBI chr13:36,301,373...36,721,569
Ensembl chr13:36,301,395...36,910,254

G

fatty acid synthase

decreases expression
increases expression

nickel sulfate results in decreased expression of FASN mRNA
nickel sulfate results in increased expression of FASN mRNA

PMID:16100012 PMID:16780908

NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373

G

failed axon connections homolog

increases expression

nickel sulfate results in increased expression of FAXC mRNA

NCBI chr 4:21,930,906...22,001,461
Ensembl chr 4:21,931,329...21,996,839

G

fibulin 2

decreases expression

nickel sulfate results in decreased expression of FBLN2 mRNA

NCBI chr 6:91,189,442...91,249,522
Ensembl chr 6:91,189,437...91,249,522

G

fibrillin 1

decreases expression

nickel sulfate results in decreased expression of FBN1 mRNA

NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913

G

fibrillin 2

decreases expression

nickel sulfate results in decreased expression of FBN2 mRNA

NCBI chr18:58,141,689...58,343,200
Ensembl chr18:58,141,695...58,343,559

G

F-box protein 32

increases expression

nickel sulfate results in increased expression of FBXO32 mRNA

NCBI chr15:58,039,275...58,078,288
Ensembl chr15:58,039,275...58,078,328

G

F-box protein 4

decreases expression

nickel sulfate results in decreased expression of FBXO4 mRNA

NCBI chr15:3,993,046...4,009,055
Ensembl chr15:3,994,927...4,009,055

G

f-box protein 9

decreases expression

nickel sulfate results in decreased expression of FBXO9 mRNA

NCBI chr 9:77,988,781...78,016,347
Ensembl chr 9:77,988,781...78,016,347

G

F-box and WD-40 domain protein 7

multiple interactions

FBXW7 mRNA affects the reaction [nickel sulfate results in increased degradation of MYC protein]; FBXW7 protein affects the reaction [nickel sulfate results in increased degradation of MYC protein]

NCBI chr 3:84,721,901...84,886,505
Ensembl chr 3:84,722,575...84,886,505

G

Fc receptor, IgG, low affinity IIb

increases expression

nickel sulfate results in increased expression of FCGR2B mRNA

NCBI chr 1:170,786,186...170,804,141
Ensembl chr 1:170,786,186...170,804,116

G

ferrochelatase

increases expression

nickel sulfate results in increased expression of FECH mRNA

NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322

G

fetuin beta

decreases expression

nickel sulfate results in decreased expression of FETUB mRNA

NCBI chr16:22,737,132...22,758,518
Ensembl chr16:22,737,084...22,758,528

G

fasciculation and elongation protein zeta 2

increases expression

nickel sulfate results in increased expression of FEZ2 mRNA

NCBI chr17:78,676,641...78,725,581
Ensembl chr17:78,676,641...78,725,581

G

fibroblast growth factor 1

decreases expression

nickel sulfate results in decreased expression of FGF1 mRNA

NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525

G

fibroblast growth factor 2

increases expression

nickel sulfate results in increased expression of FGF2 mRNA

NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257

G

fibroblast growth factor 5

decreases expression

nickel sulfate results in decreased expression of FGF5 mRNA

NCBI chr 5:98,402,108...98,424,892
Ensembl chr 5:98,402,043...98,424,889

G

fibroblast growth factor receptor 2

increases expression

nickel sulfate results in increased expression of FGFR2 protein

NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079

G

fibrinogen-like protein 2

decreases expression

nickel sulfate results in decreased expression of FGL2 mRNA

PMID:16780908 PMID:17374397

NCBI chr 5:21,577,671...21,583,384
Ensembl chr 5:21,577,640...21,583,372

G

filamin A interacting protein 1-like

decreases expression

nickel sulfate results in decreased expression of FILIP1L mRNA

NCBI chr16:57,173,376...57,393,167
Ensembl chr16:57,173,456...57,393,489

G

FK506 binding protein 1a

decreases expression

nickel sulfate results in decreased expression of FKBP1A mRNA

NCBI chr 2:151,384,403...151,403,611
Ensembl chr 2:151,384,403...151,403,612

G

FK506 binding protein 1b

decreases expression

nickel sulfate results in decreased expression of FKBP1B mRNA

NCBI chr12:4,883,174...4,891,736
Ensembl chr12:4,883,174...4,891,591

G

filaggrin

decreases expression

nickel sulfate results in decreased expression of FLG mRNA

NCBI chr 3:93,180,853...93,200,996
Ensembl chr 3:93,180,830...93,200,993

G

Friend leukemia integration 1

increases expression

nickel sulfate results in increased expression of FLI1 mRNA

NCBI chr 9:32,333,500...32,454,292
Ensembl chr 9:32,333,500...32,454,157

G

filamin, alpha

increases expression

nickel sulfate results in increased expression of FLNA mRNA

NCBI chr X:73,267,067...73,293,787
Ensembl chr X:73,267,067...73,293,426

G

filamin C, gamma

decreases expression

nickel sulfate results in decreased expression of FLNC mRNA

NCBI chr 6:29,433,150...29,461,888
Ensembl chr 6:29,433,255...29,461,882

G

flotillin 1

increases expression

nickel sulfate results in increased expression of FLOT1 mRNA

NCBI chr17:36,134,243...36,143,674
Ensembl chr17:36,134,122...36,143,683

G

FMS-like tyrosine kinase 1

increases expression

nickel sulfate results in increased expression of FLT1 mRNA

NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821

G

FMS-like tyrosine kinase 3 ligand

decreases expression

nickel sulfate results in decreased expression of FLT3L mRNA

NCBI chr 7:44,780,607...44,785,914
Ensembl chr 7:44,779,212...44,785,856

G

fragile X messenger ribonucleoprotein 1

decreases expression

nickel sulfate results in decreased expression of FMR1 mRNA

NCBI chr X:67,722,144...67,761,569
Ensembl chr X:67,722,147...67,761,569

G

fibronectin 1

increases expression

nickel sulfate results in increased expression of FN1 mRNA; nickel sulfate results in increased expression of FN1 protein

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

fibronectin type III domain containing 3A

increases expression

nickel sulfate results in increased expression of FNDC3A mRNA

NCBI chr14:72,775,388...72,948,141
Ensembl chr14:72,775,386...72,947,443

G

FBJ osteosarcoma oncogene

increases expression

nickel sulfate results in increased expression of FOS mRNA

PMID:16780908 PMID:19131640

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

fos-like antigen 2

decreases expression
increases expression

nickel sulfate results in decreased expression of FOSL2 mRNA
nickel sulfate results in increased expression of FOSL2 mRNA

PMID:16780908 PMID:17374397

NCBI chr 5:32,292,599...32,315,184
Ensembl chr 5:32,293,145...32,315,186

G

forkhead box C2

increases expression

nickel sulfate results in increased expression of FOXC2 mRNA

NCBI chr 8:121,842,910...121,845,634
Ensembl chr 8:121,842,910...121,845,634

G

forkhead box F2

increases expression

nickel sulfate results in increased expression of FOXF2 mRNA

NCBI chr13:31,809,686...31,815,390
Ensembl chr13:31,809,799...31,815,386

G

formyl peptide receptor 3

increases expression

nickel sulfate results in increased expression of FPR3 mRNA

NCBI chr17:18,190,720...18,191,939
Ensembl chr17:18,108,114...18,191,939

G

FERM domain containing 3

increases expression

nickel sulfate results in increased expression of FRMD3 mRNA

NCBI chr 4:73,931,454...74,120,451
Ensembl chr 4:73,931,679...74,120,451

G

FERM domain containing 4A

decreases expression

nickel sulfate results in decreased expression of FRMD4A mRNA

NCBI chr 2:4,022,461...4,618,854
Ensembl chr 2:4,022,528...4,618,854

G

FERM domain containing 5

decreases expression

nickel sulfate results in decreased expression of FRMD5 mRNA

NCBI chr 2:121,376,010...121,637,580
Ensembl chr 2:121,376,010...121,637,568

G

FRY microtubule binding protein

decreases expression

nickel sulfate results in decreased expression of FRY mRNA

NCBI chr 5:150,042,083...150,421,218
Ensembl chr 5:150,042,110...150,421,218

G

follistatin

increases expression

nickel sulfate results in increased expression of FST mRNA

NCBI chr13:114,588,798...114,595,522
Ensembl chr13:114,588,826...114,595,487

G

follistatin-like 3

decreases expression

nickel sulfate results in decreased expression of FSTL3 mRNA

NCBI chr10:79,613,108...79,618,464
Ensembl chr10:79,613,106...79,618,464

G

ferritin heavy polypeptide 1

increases expression

nickel sulfate results in increased expression of FTH1 mRNA

NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462

G

ferritin light polypeptide 1

increases expression

nickel sulfate results in increased expression of FTL mRNA

NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308

G

ferritin mitochondrial

increases expression

nickel sulfate results in increased expression of FTMT protein

NCBI chr18:52,464,608...52,466,068
Ensembl chr18:52,464,621...52,466,068

G

fucosidase, alpha-L- 1, tissue

decreases expression

nickel sulfate results in decreased expression of FUCA1 mRNA

NCBI chr 4:135,648,037...135,667,611
Ensembl chr 4:135,648,046...135,667,622

G

FUN14 domain containing 2

decreases expression

nickel sulfate results in decreased expression of FUNDC2 mRNA

NCBI chr X:74,426,005...74,440,764
Ensembl chr X:74,426,005...74,440,065

G

fused in sarcoma

increases expression

nickel sulfate results in increased expression of FUS mRNA

NCBI chr 7:127,565,276...127,581,204
Ensembl chr 7:127,566,629...127,584,873

G

Fyn proto-oncogene

increases expression

nickel sulfate results in increased expression of FYN mRNA

NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377

G

frizzled class receptor 2

decreases expression

nickel sulfate results in decreased expression of FZD2 mRNA

PMID:16100012 PMID:16166746

NCBI chr11:102,495,257...102,498,884
Ensembl chr11:102,495,222...102,498,884

G

frizzled class receptor 3

decreases expression

nickel sulfate results in decreased expression of FZD3 mRNA

NCBI chr14:65,429,890...65,499,912
Ensembl chr14:65,429,898...65,499,912

G

frizzled class receptor 6

increases expression

nickel sulfate results in increased expression of FZD6 mRNA

NCBI chr15:38,869,673...38,901,587
Ensembl chr15:38,869,429...38,901,583

G

glucose-6-phosphate dehydrogenase X-linked

increases expression
multiple interactions
decreases activity

nickel sulfate results in increased expression of G6PD mRNA
naringin inhibits the reaction [nickel sulfate results in decreased activity of G6PD protein]

PMID:20566472 PMID:20950607

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

GABA type A receptor associated protein like 1

increases expression

nickel sulfate results in increased expression of GABARAPL1 mRNA

NCBI chr 6:129,510,155...129,519,294
Ensembl chr 6:129,510,123...129,519,309

G

glutamate decarboxylase 1

increases expression

nickel sulfate results in increased expression of GAD1 mRNA

NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358

G

galanin and GMAP prepropeptide

decreases expression

nickel sulfate results in decreased expression of GAL mRNA

NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544

G

galactose-3-O-sulfotransferase 4

increases expression

nickel sulfate results in increased expression of GAL3ST4 mRNA

NCBI chr 5:138,263,180...138,271,261
Ensembl chr 5:138,263,183...138,271,102

G

galactosylceramidase

decreases expression

nickel sulfate results in decreased expression of GALC mRNA

NCBI chr12:98,168,543...98,226,565
Ensembl chr12:98,168,553...98,225,718

G

galactosamine (N-acetyl)-6-sulfatase

increases expression

nickel sulfate results in increased expression of GALNS mRNA

NCBI chr 8:123,304,976...123,338,226
Ensembl chr 8:123,304,981...123,338,202

G

giant axonal neuropathy

increases expression

nickel sulfate results in increased expression of GAN mRNA

NCBI chr 8:117,884,720...117,932,573
Ensembl chr 8:117,884,874...117,942,736

G

glyceraldehyde-3-phosphate dehydrogenase

affects expression

nickel sulfate affects the expression of GAPDH mRNA

NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430

G

growth arrest specific 6

decreases expression

nickel sulfate results in decreased expression of GAS6 mRNA

NCBI chr 8:13,515,374...13,544,535
Ensembl chr 8:13,515,374...13,544,490

G

growth arrest specific 8

increases expression

nickel sulfate results in increased expression of GAS8 mRNA

NCBI chr 8:124,245,630...124,263,394
Ensembl chr 8:124,245,573...124,263,389

G

glycine amidinotransferase (L-arginine:glycine amidinotransferase)

decreases expression

nickel sulfate results in decreased expression of GATM mRNA

NCBI chr 2:122,424,954...122,441,758
Ensembl chr 2:122,424,948...122,441,784

G

guanylate binding protein 2b

increases expression

nickel sulfate results in increased expression of GBP1 mRNA

NCBI chr 3:142,300,577...142,324,940
Ensembl chr 3:142,300,608...142,324,940

G

guanylate binding protein 3

increases expression

nickel sulfate results in increased expression of GBP4 mRNA

NCBI chr 3:142,265,781...142,278,974
Ensembl chr 3:142,265,787...142,278,970

G

glutamate-cysteine ligase, catalytic subunit

increases expression

nickel sulfate results in increased expression of GCLC mRNA

PMID:16100012 PMID:20491607 PMID:20566472

NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767

G

glutamate-cysteine ligase, modifier subunit

increases expression

nickel sulfate results in increased expression of GCLM mRNA

PMID:16314067 PMID:20566472

NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381

G

glucosaminyl (N-acetyl) transferase 2 (I blood group)

increases expression

nickel sulfate results in increased expression of GCNT2 mRNA

NCBI chr13:41,013,417...41,114,368
Ensembl chr13:41,013,230...41,114,368

G

glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)

increases expression

nickel sulfate results in increased expression of GCNT4 mRNA

NCBI chr13:97,060,852...97,087,422
Ensembl chr13:97,061,197...97,087,414

G

glycine cleavage system protein H (aminomethyl carrier)

increases expression

nickel sulfate results in increased expression of GCSH mRNA

NCBI chr 8:117,708,706...117,720,237
Ensembl chr 8:117,708,549...117,720,276

G

growth differentiation factor 15

increases expression

nickel sulfate results in increased expression of GDF15 mRNA

NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106

G

glial cell line derived neurotrophic factor

decreases expression

nickel sulfate results in decreased expression of GDNF mRNA

NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056

G

glutamine fructose-6-phosphate transaminase 2

increases expression

nickel sulfate results in increased expression of GFPT2 mRNA

NCBI chr11:49,684,981...49,729,448
Ensembl chr11:49,685,005...49,729,440

G

glial cell line derived neurotrophic factor family receptor alpha 2

decreases expression

nickel sulfate results in decreased expression of GFRA2 mRNA

NCBI chr14:71,127,547...71,217,280
Ensembl chr14:71,127,560...71,217,278

G

GDP-L-fucose synthase

increases expression

nickel sulfate results in increased expression of GFUS mRNA

NCBI chr15:75,796,532...75,801,613
Ensembl chr15:75,796,525...75,801,681

G

gamma-glutamyltransferase 1

increases activity
multiple interactions

nickel sulfate results in increased activity of GGT1 protein
troxerutin inhibits the reaction [nickel sulfate results in increased activity of GGT1 protein]

NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034

G

GINS complex subunit 1

decreases expression

nickel sulfate results in decreased expression of GINS1 mRNA

NCBI chr 2:150,751,482...150,773,200
Ensembl chr 2:150,747,320...150,773,200

G

GINS complex subunit 2

increases expression

nickel sulfate results in increased expression of GINS2 mRNA

NCBI chr 8:121,308,005...121,315,814
Ensembl chr 8:121,305,372...121,316,043

G

gap junction protein, alpha 1

increases expression

nickel sulfate results in increased expression of GJA1 mRNA

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

glucocorticoid induced transcript 1

decreases expression

nickel sulfate results in decreased expression of GLCCI1 mRNA

NCBI chr 6:8,509,600...8,597,549
Ensembl chr 6:8,509,600...8,597,548

G

GLI pathogenesis related 1

decreases expression

nickel sulfate results in decreased expression of GLIPR1 mRNA

NCBI chr10:111,821,353...111,838,539
Ensembl chr10:111,821,353...111,838,536

G

GLI pathogenesis-related 2

decreases expression

nickel sulfate results in decreased expression of GLIPR2 mRNA

NCBI chr 4:43,957,702...43,979,118
Ensembl chr 4:43,957,401...43,979,118

G

GLIS family zinc finger 3

decreases expression

nickel sulfate results in decreased expression of GLIS3 mRNA

NCBI chr19:28,236,251...28,657,684
Ensembl chr19:28,236,251...28,657,477

G

glucagon-like peptide 2 receptor

increases expression

nickel sulfate results in increased expression of GLP2R mRNA

NCBI chr11:67,554,877...67,661,979
Ensembl chr11:67,552,328...67,661,979

G

glycine receptor, beta subunit

decreases expression

nickel sulfate results in decreased expression of GLRB mRNA

NCBI chr 3:80,750,905...80,820,994
Ensembl chr 3:80,750,906...80,820,967

G

glutamate-ammonia ligase

increases expression

nickel sulfate results in increased expression of GLUL mRNA

NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469

G

predicted gene, 24313

increases expression

nickel sulfate results in increased expression of SNORA5A mRNA

NCBI chr11:6,569,808...6,569,940
Ensembl chr11:6,569,808...6,569,940

G

predicted gene, 25636

decreases expression

nickel sulfate results in decreased expression of SNORA13 mRNA

NCBI chr 7:109,622,417...109,622,549
Ensembl chr 7:109,622,417...109,622,549

G

GM2 ganglioside activator protein

decreases expression
increases expression

nickel sulfate results in decreased expression of GM2A mRNA
nickel sulfate results in increased expression of GM2A mRNA

NCBI chr11:54,988,811...55,003,855
Ensembl chr11:54,988,941...55,003,855

G

predicted gene, 40318

increases expression

nickel sulfate results in increased expression of S100P mRNA

NCBI chr 5:36,919,848...36,924,763
Ensembl chr 5:36,919,961...36,924,039

G

predicted gene 7030

increases expression

nickel sulfate results in increased expression of HLA-F mRNA

NCBI chr17:36,438,501...36,440,317
Ensembl chr17:36,420,611...36,440,317

G

guanosine monophosphate reductase

increases expression

nickel sulfate results in increased expression of GMPR mRNA

NCBI chr13:45,660,905...45,699,862
Ensembl chr13:45,660,920...45,707,276

G

guanine nucleotide binding protein, alpha 15

increases expression

nickel sulfate results in increased expression of GNA15 mRNA

NCBI chr10:81,338,147...81,360,283
Ensembl chr10:81,338,140...81,360,059

G

guanine nucleotide binding protein, alpha stimulating, olfactory type

increases expression

nickel sulfate results in increased expression of GNAL mRNA

NCBI chr18:67,221,369...67,359,863
Ensembl chr18:67,221,287...67,359,863

G

guanine nucleotide binding protein, alpha z subunit

increases expression

nickel sulfate results in increased expression of GNAZ mRNA

NCBI chr10:74,803,009...74,852,739
Ensembl chr10:74,803,009...74,852,739

G

guanine nucleotide binding protein (G protein), beta 2

increases expression

nickel sulfate results in increased expression of GNB2 mRNA

NCBI chr 5:137,526,389...137,533,085
Ensembl chr 5:137,526,389...137,531,772

G

guanine nucleotide binding protein (G protein), gamma 11

increases expression

nickel sulfate results in increased expression of GNG11 mRNA

NCBI chr 6:4,003,987...4,008,445
Ensembl chr 6:4,003,904...4,008,445

G

glycoprotein 9 platelet

increases expression

nickel sulfate results in increased expression of GP9 mRNA

NCBI chr 6:87,753,115...87,756,768
Ensembl chr 6:87,755,054...87,756,750

G

glycerol-3-phosphate acyltransferase 3

increases expression

nickel sulfate results in increased expression of GPAT3 mRNA

NCBI chr 5:100,994,095...101,046,968
Ensembl chr 5:100,993,579...101,046,968

G

G patch domain containing 2 like

decreases expression

nickel sulfate results in decreased expression of GPATCH2L mRNA

NCBI chr12:86,288,569...86,341,439
Ensembl chr12:86,288,632...86,338,558

G

glypican 4

increases expression

nickel sulfate results in increased expression of GPC4 mRNA

NCBI chr X:51,139,884...51,253,800
Ensembl chr X:51,141,898...51,254,129

G

G protein-coupled estrogen receptor 1

increases expression

nickel sulfate results in increased expression of GPER1 mRNA

NCBI chr 5:139,408,905...139,413,555
Ensembl chr 5:139,408,906...139,413,555

G

gephyrin

decreases expression

nickel sulfate results in decreased expression of GPHN mRNA

NCBI chr12:78,264,099...78,731,546
Ensembl chr12:78,273,153...78,731,546

G

glycoprotein m6b

increases expression

nickel sulfate results in increased expression of GPM6B mRNA

NCBI chr X:165,021,911...165,172,028
Ensembl chr X:165,021,907...165,171,984

G

glycoprotein (transmembrane) nmb

increases expression

nickel sulfate results in increased expression of GPNMB mRNA

PMID:16314067 PMID:22714537

NCBI chr 6:49,013,449...49,044,413
Ensembl chr 6:49,013,480...49,047,863

G

G protein-coupled receptor 39

increases expression

nickel sulfate results in increased expression of GPR39 mRNA

NCBI chr 1:125,604,725...125,804,132
Ensembl chr 1:125,604,732...125,801,599

G

G protein-coupled receptor 4

decreases expression

nickel sulfate results in decreased expression of GPR4 mRNA

NCBI chr 7:18,946,463...18,958,101
Ensembl chr 7:18,946,463...18,958,099

G

G protein-coupled receptor, family C, group 5, member B

increases expression

nickel sulfate results in increased expression of GPRC5B mRNA

NCBI chr 7:118,571,263...118,594,434
Ensembl chr 7:118,571,270...118,594,434

G

glutamic pyruvic transaminase, soluble

increases activity
multiple interactions

nickel sulfate results in increased activity of GPT protein
troxerutin inhibits the reaction [nickel sulfate results in increased activity of GPT protein]
puerarin inhibits the reaction [nickel sulfate results in increased activity of GPT protein]

PMID:24112957 PMID:26607348

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione peroxidase 3

increases expression

nickel sulfate results in increased expression of GPX3 mRNA

NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203

G

glutathione peroxidase 4

increases expression
multiple interactions

nickel sulfate results in increased expression of GPX4 mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of GPX4 mRNA

PMID:18651567 PMID:31734292

NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273

G

glutathione peroxidase 7

decreases expression

nickel sulfate results in decreased expression of GPX7 mRNA

NCBI chr 4:108,257,414...108,263,910
Ensembl chr 4:108,257,587...108,264,158

G

GRAM domain containing 1C

increases expression

nickel sulfate results in increased expression of GRAMD1C mRNA

NCBI chr16:43,800,713...43,883,757
Ensembl chr16:43,800,713...43,883,708

G

gremlin 1, DAN family BMP antagonist

decreases expression

nickel sulfate results in decreased expression of GREM1 mRNA

NCBI chr 2:113,579,020...113,588,993
Ensembl chr 2:113,576,509...113,588,991

G

genetic suppressor element 1, coiled-coil protein

increases expression

nickel sulfate results in increased expression of GSE1 mRNA

NCBI chr 8:120,955,233...121,308,122
Ensembl chr 8:120,955,195...121,308,129

G

glycogen synthase kinase 3 beta

increases expression

nickel sulfate results in increased expression of GSK3B mRNA

NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446

G

gelsolin

increases expression

nickel sulfate results in increased expression of GSN mRNA

NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904

G

G1 to S phase transition 2

decreases expression

nickel sulfate results in decreased expression of GSPT2 mRNA

NCBI chr X:93,679,675...93,682,168
Ensembl chr X:93,679,675...93,686,850

G

glutathione reductase

increases expression
multiple interactions
decreases activity

nickel sulfate results in increased expression of GSR mRNA
naringin inhibits the reaction [nickel sulfate results in decreased activity of GSR protein]

PMID:20566472 PMID:20950607

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

general transcription factor IIB

increases expression

nickel sulfate results in increased expression of GTF2B mRNA

NCBI chr 3:142,471,008...142,489,367
Ensembl chr 3:142,470,806...142,489,367

G

GTP binding protein 6 (putative)

increases expression

nickel sulfate results in increased expression of GTPBP6 mRNA

NCBI chr 5:110,251,842...110,256,063
Ensembl chr 5:110,251,841...110,256,063

G

guanylate kinase 1

increases expression

nickel sulfate results in increased expression of GUK1 mRNA

NCBI chr11:59,074,696...59,083,068
Ensembl chr11:59,074,701...59,083,069

G

GULP, engulfment adaptor PTB domain containing 1

increases expression

nickel sulfate results in increased expression of GULP1 mRNA

NCBI chr 1:44,590,540...44,835,998
Ensembl chr 1:44,590,671...44,835,998

G

GDNF-inducible zinc finger protein 1

decreases expression

nickel sulfate results in decreased expression of GZF1 mRNA

NCBI chr 2:148,521,305...148,534,869
Ensembl chr 2:148,522,943...148,534,869

G

granzyme F

decreases expression

nickel sulfate results in decreased expression of GZMF mRNA

NCBI chr14:56,442,720...56,448,864
Ensembl chr14:56,442,720...56,448,874

G

H1.0 linker histone

decreases expression

nickel sulfate results in decreased expression of H1-0 mRNA

NCBI chr15:78,912,412...78,914,704
Ensembl chr15:78,912,650...78,914,704

G

H1.10 linker histone

increases expression

nickel sulfate results in increased expression of H1-10 mRNA

NCBI chr 6:87,957,403...87,958,464
Ensembl chr 6:87,957,403...87,958,619

G

histocompatibility 2, class II, locus DMa

decreases expression

nickel sulfate results in decreased expression of HLA-DMA mRNA

NCBI chr17:34,338,667...34,358,075
Ensembl chr17:34,338,515...34,358,075

G

histocompatibility 2, M region locus 2

increases expression

nickel sulfate results in increased expression of HLA-B mRNA

NCBI chr17:37,791,742...37,794,445
Ensembl chr17:37,791,742...37,794,443

G

H2A clustered histone 10

increases expression

nickel sulfate results in increased expression of H2AC14 mRNA

NCBI chr13:23,718,045...23,718,548
Ensembl chr13:23,718,076...23,718,474

G

H2A clustered histone 18

increases expression

nickel sulfate results in increased expression of H2AC18 mRNA

NCBI chr 3:96,152,853...96,153,439
Ensembl chr 3:96,152,813...96,153,398

G

H3.4 histone, cluster member

increases methylation

nickel sulfate results in increased methylation of H3-4 protein
nickel sulfate results in increased methylation of H3F4 protein

NCBI chr11:58,852,537...58,853,099
Ensembl chr11:58,852,599...58,853,364

G

H4 clustered histone 3

decreases expression

nickel sulfate results in decreased expression of H4C6 mRNA

NCBI chr13:23,882,067...23,882,441
Ensembl chr13:23,881,618...23,882,437

G

3-hydroxyacyl-CoA dehydratase 4

decreases expression

nickel sulfate results in decreased expression of HACD4 mRNA

NCBI chr 4:88,325,924...88,357,175
Ensembl chr 4:88,314,381...88,357,165

G

hemoglobin alpha, adult chain 1

affects expression

nickel sulfate affects the expression of HBA-A1 mRNA

NCBI chr11:32,233,672...32,234,486
Ensembl chr11:32,233,511...32,234,465

G

hemoglobin, beta adult minor chain

decreases expression

nickel sulfate results in decreased expression of HBB-B2 mRNA

G

hemolytic complement

affects expression
decreases expression

nickel sulfate affects the expression of HC mRNA
nickel sulfate results in decreased expression of HC mRNA

PMID:12718980 PMID:16166746

NCBI chr 2:34,873,341...34,958,518
Ensembl chr 2:34,873,343...34,951,450

G

HEAT repeat containing 5B

decreases expression

nickel sulfate results in decreased expression of HEATR5B mRNA

NCBI chr17:79,060,335...79,142,810
Ensembl chr17:79,060,327...79,142,793

G

hect domain and RLD 4

decreases expression

nickel sulfate results in decreased expression of HERC4 mRNA

NCBI chr10:63,079,122...63,153,660
Ensembl chr10:63,079,589...63,153,657

G

hect domain and RLD 6

increases expression

nickel sulfate results in increased expression of HERC6 mRNA

NCBI chr 6:57,557,977...57,642,121
Ensembl chr 6:57,557,985...57,641,617

G

hes family bHLH transcription factor 1

increases expression

nickel sulfate results in increased expression of HES1 mRNA

NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614

G

hypoxia inducible factor 1, alpha subunit

increases expression
multiple interactions
decreases expression
decreases hydroxylation
increases stability

nickel sulfate results in increased expression of HIF1A mRNA; nickel sulfate results in increased expression of HIF1A protein
[chromium hexavalent ion co-treated with nickel sulfate] results in increased expression of HIF1A protein; [HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in decreased expression of USP28 protein]; [HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in increased degradation of MYC protein]; [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in decreased expression of HIF1A mRNA; [nickel sulfate co-treated with Dinoprostone] results in increased expression of HIF1A protein; [nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of HIF1A protein; [potassium chromate(VI) co-treated with nickel sulfate] results in increased expression of HIF1A protein; [U 0126 co-treated with SB 203580] inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of HIF1A protein]; Ascorbic Acid inhibits the reaction [nickel sulfate results in decreased hydroxylation of HIF1A protein]; Ascorbic Acid inhibits the reaction [nickel sulfate results in increased expression of HIF1A protein]; Ascorbic Acid inhibits the reaction [nickel sulfate results in increased stability of HIF1A protein]; Dinoprostone promotes the reaction [nickel sulfate results in increased expression of and results in increased activity of HIF1A protein]; HIF1A mRNA affects the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of PTGS2 mRNA]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of PTGS2 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL1 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL5 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL8 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of VEGFA protein]; HIF1A protein promotes the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]; macrophage stimulatory lipopeptide 2 co-treated with [nickel sulfate results in increased expression of HIF1A protein]; nickel sulfate affects the localization of and results in increased stability of HIF1A protein; nickel sulfate promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; nickel sulfate results in increased expression of and results in increased activity of HIF1A protein; SB 203580 inhibits the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased expression of HIF1A protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased expression of HIF1A protein]; U 0126 inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of HIF1A protein]
nickel sulfate results in decreased expression of HIF1A mRNA

PMID:16288478 PMID:16314067 PMID:17382205 PMID:18832182 PMID:19074761 More...

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

hypoxia inducible lipid droplet associated

increases expression

nickel sulfate results in increased expression of HILPDA mRNA

NCBI chr 6:29,272,487...29,275,448
Ensembl chr 6:29,272,487...29,275,445

G

histidine triad nucleotide binding protein 3

increases expression

nickel sulfate results in increased expression of HINT3 mRNA

NCBI chr10:30,479,191...30,499,526
Ensembl chr10:30,484,137...30,505,628

G

huntingtin interacting protein 1

increases expression

nickel sulfate results in increased expression of HIP1 mRNA

NCBI chr 5:135,435,350...135,574,167
Ensembl chr 5:135,435,385...135,573,974

G

homeodomain interacting protein kinase 2

increases expression

nickel sulfate results in increased expression of HIPK2 mRNA

NCBI chr 6:38,664,447...38,853,236
Ensembl chr 6:38,671,325...38,853,099

G

human immunodeficiency virus type I enhancer binding protein 1

increases expression

nickel sulfate results in increased expression of HIVEP1 mRNA

PMID:16780908 PMID:22714537

NCBI chr13:42,205,304...42,338,504
Ensembl chr13:42,205,497...42,346,013

G

hexokinase 2

decreases expression

nickel sulfate results in decreased expression of HK2 mRNA

NCBI chr 6:82,702,004...82,751,437
Ensembl chr 6:82,702,006...82,751,435

G

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

increases expression

nickel sulfate results in increased expression of HMGCS1 mRNA

NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796

G

heme oxygenase 1

increases expression
decreases expression
multiple interactions

nickel sulfate results in increased expression of HMOX1 mRNA
nickel sulfate results in decreased expression of HMOX1 protein
Quercetin inhibits the reaction [nickel sulfate results in decreased expression of HMOX1 protein]

PMID:16314067 PMID:19033392 PMID:20146380 PMID:20491607 PMID:20566472 More...

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

heterogeneous nuclear ribonucleoprotein A1

increases expression

nickel sulfate results in increased expression of HNRNPA1 mRNA

NCBI chr15:103,148,840...103,155,119
Ensembl chr15:103,148,859...103,155,119

G

homer scaffolding protein 1

increases expression

nickel sulfate results in increased expression of HOMER1 mRNA

NCBI chr13:93,440,265...93,549,471
Ensembl chr13:93,436,143...93,541,637

G

homeobox A1

increases expression

nickel sulfate results in increased expression of HOXA1 mRNA

NCBI chr 6:52,132,573...52,135,299
Ensembl chr 6:52,132,570...52,135,297

G

homeobox A2

increases expression

nickel sulfate results in increased expression of HOXA2 mRNA

NCBI chr 6:52,139,389...52,141,808
Ensembl chr 6:52,139,397...52,141,811

G

homeobox A3

increases expression

nickel sulfate results in increased expression of HOXA3 mRNA

NCBI chr 6:52,146,039...52,190,316
Ensembl chr 6:52,146,042...52,190,316

G

homeobox C10

increases expression

nickel sulfate results in increased expression of HOXC10 mRNA

NCBI chr15:102,875,231...102,880,333
Ensembl chr15:102,875,231...102,880,328

G

homeobox C13

increases expression

nickel sulfate results in increased expression of HOXC13 mRNA

NCBI chr15:102,829,566...102,837,249
Ensembl chr15:102,829,538...102,837,249

G

homeobox C9

increases expression

nickel sulfate results in increased expression of HOXC9 mRNA

NCBI chr15:102,885,467...102,893,324
Ensembl chr15:102,884,874...102,893,531

G

hippocalcin-like 1

increases expression

nickel sulfate results in increased expression of HPCAL1 mRNA

NCBI chr12:17,740,810...17,841,943
Ensembl chr12:17,740,857...17,841,934

G

hydroxyprostaglandin dehydrogenase 15 (NAD)

decreases expression

nickel sulfate results in decreased expression of HPGD mRNA

NCBI chr 8:56,747,587...56,774,081
Ensembl chr 8:56,747,620...56,774,078

G

hypoxanthine phosphoribosyltransferase 1

affects expression

nickel sulfate affects the expression of HPRT1 mRNA

NCBI chr X:52,076,955...52,110,537
Ensembl chr X:52,077,014...52,110,536

G

HPS5, biogenesis of lysosomal organelles complex 2 subunit 2

increases expression

nickel sulfate results in increased expression of HPS5 mRNA

NCBI chr 7:46,409,890...46,445,501
Ensembl chr 7:46,409,890...46,445,488

G

heparan sulfate 6-O-sulfotransferase 1

increases expression

nickel sulfate results in increased expression of HS6ST1 mRNA

NCBI chr 1:36,107,481...36,145,527
Ensembl chr 1:36,107,481...36,145,527

G

hydroxysteroid (17-beta) dehydrogenase 3

decreases expression
multiple interactions

nickel sulfate results in decreased expression of HSD17B3 mRNA
[CGA protein co-treated with nickel sulfate] results in decreased expression of HSD17B3 mRNA; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA]

NCBI chr13:64,206,088...64,237,076
Ensembl chr13:64,206,080...64,237,044

G

hydroxysteroid (17-beta) dehydrogenase 6

increases expression

nickel sulfate results in increased expression of HSD17B6 mRNA

NCBI chr10:127,826,800...127,843,517
Ensembl chr10:127,826,805...127,843,480

G

hydroxysteroid (17-beta) dehydrogenase 7

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of HSD17B7 mRNA

NCBI chr 1:169,777,109...169,796,757
Ensembl chr 1:169,777,104...169,796,810

G

hydroxysteroid dehydrogenase like 1

increases expression

nickel sulfate results in increased expression of HSDL1 mRNA

NCBI chr 8:120,288,717...120,301,930
Ensembl chr 8:120,288,728...120,301,922

G

heat shock factor 1

increases expression

nickel sulfate results in increased expression of HSF1 mRNA

NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113

G

heat shock protein 12A

increases expression

nickel sulfate results in increased expression of HSPA12A mRNA

NCBI chr19:58,784,182...58,932,104
Ensembl chr19:58,784,182...58,932,086

G

heat shock protein 1A

increases expression

nickel sulfate results in increased expression of HSPA1A mRNA

NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132

G

heat shock protein 5

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein]
nickel sulfate results in increased expression of HSPA5 mRNA; nickel sulfate results in increased expression of HSPA5 protein

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

heat shock protein 8

increases expression

nickel sulfate results in increased expression of HSPB8 mRNA

NCBI chr 5:116,546,550...116,560,923
Ensembl chr 5:116,546,550...116,560,923

G

perlecan (heparan sulfate proteoglycan 2)

decreases expression

nickel sulfate results in decreased expression of HSPG2 mRNA

NCBI chr 4:137,196,062...137,297,941
Ensembl chr 4:137,196,080...137,297,941

G

HIV-1 Tat interactive protein 2

increases expression

nickel sulfate results in increased expression of HTATIP2 mRNA

NCBI chr 7:49,408,761...49,423,748
Ensembl chr 7:49,408,863...49,423,723

G

5-hydroxytryptamine (serotonin) receptor 1D

increases expression

nickel sulfate results in increased expression of HTR1D mRNA

NCBI chr 4:136,150,835...136,171,716
Ensembl chr 4:136,150,835...136,171,709

G

5-hydroxytryptamine (serotonin) receptor 7

decreases expression

nickel sulfate results in decreased expression of HTR7 mRNA

NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907

G

intercellular adhesion molecule 1

increases expression
affects expression

nickel sulfate results in increased expression of ICAM1 mRNA
nickel sulfate affects the expression of ICAM1 mRNA
nickel sulfate results in increased expression of ICAM1 protein

PMID:11114790 PMID:18202158 PMID:19702435 PMID:20417223 PMID:29540657

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

inhibitor of DNA binding 1, HLH protein

increases expression

nickel sulfate results in increased expression of ID1 mRNA

NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330

G

inhibitor of DNA binding 2

increases expression

nickel sulfate results in increased expression of ID2 mRNA

PMID:16780908 PMID:20146380

NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139

G

inhibitor of DNA binding 3

increases expression

nickel sulfate results in increased expression of ID3 mRNA

NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066

G

inhibitor of DNA binding 4

increases expression

nickel sulfate results in increased expression of ID4 mRNA

NCBI chr13:48,414,592...48,419,504
Ensembl chr13:48,414,704...48,419,502

G

isocitrate dehydrogenase 3 (NAD+) beta

decreases expression

nickel sulfate results in decreased expression of IDH3B mRNA

NCBI chr 2:130,121,229...130,126,371
Ensembl chr 2:130,121,229...130,126,467

G

indoleamine 2,3-dioxygenase 1

increases expression

nickel sulfate results in increased expression of IDO1 mRNA

NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025

G

iduronate 2-sulfatase

decreases expression

nickel sulfate results in decreased expression of IDS mRNA

NCBI chr X:69,386,675...69,429,437
Ensembl chr X:69,386,675...69,408,690

G

immediate early response 2

increases expression

nickel sulfate results in increased expression of IER2 mRNA

NCBI chr 8:85,387,960...85,389,481
Ensembl chr 8:85,387,960...85,389,483

G

immediate early response 3

increases expression

nickel sulfate results in increased expression of IER3 mRNA

PMID:17374397 PMID:18651567 PMID:22714537

NCBI chr17:36,132,605...36,133,803
Ensembl chr17:36,132,576...36,133,815

G

interferon activated gene 205

increases expression

nickel sulfate results in increased expression of IFI205 mRNA

NCBI chr 1:173,839,549...173,859,617
Ensembl chr 1:173,839,564...173,859,376

G

interferon gamma inducible protein 30

increases expression

nickel sulfate results in increased expression of IFI30 mRNA

NCBI chr 8:71,215,418...71,219,307
Ensembl chr 8:71,215,419...71,219,307

G

interferon-induced protein 44

increases expression

nickel sulfate results in increased expression of IFI44 mRNA

NCBI chr 3:151,436,559...151,455,580
Ensembl chr 3:151,436,559...151,455,597

G

interferon induced with helicase C domain 1

increases expression

nickel sulfate results in increased expression of IFIH1 mRNA

NCBI chr 2:62,426,137...62,476,599
Ensembl chr 2:62,426,142...62,476,599

G

interferon induced protein with tetratricpeptide repeats 1B like 1

decreases expression
increases expression

nickel sulfate results in decreased expression of IFIT1 mRNA
nickel sulfate results in increased expression of IFIT1 mRNA

PMID:18651567 PMID:22714537

NCBI chr19:34,570,288...34,640,382
Ensembl chr19:34,570,291...34,579,356

G

interferon-induced protein with tetratricopeptide repeats 2

decreases expression

nickel sulfate results in decreased expression of IFIT2 mRNA

NCBI chr19:34,527,961...34,553,934
Ensembl chr19:34,528,094...34,553,819

G

interferon induced transmembrane protein 1

increases expression

nickel sulfate results in increased expression of IFITM1 mRNA

NCBI chr 7:140,547,342...140,549,740
Ensembl chr 7:140,547,134...140,549,738

G

interferon beta 1, fibroblast

increases expression

nickel sulfate results in increased expression of IFNB1 mRNA

NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011

G

interferon epsilon

decreases expression

nickel sulfate results in decreased expression of IFNE mRNA

NCBI chr 4:88,797,775...88,798,438
Ensembl chr 4:88,797,775...88,798,438

G

interferon gamma

multiple interactions
increases expression
affects expression
increases secretion

[nickel sulfate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Cholecalciferol inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; Cyclosporine inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; Dimethyl Fumarate inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; Hydrocortisone inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; IFNG protein promotes the reaction [nickel sulfate results in increased expression of IL27 mRNA]; Zinc Sulfate inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]
nickel sulfate results in increased expression of IFNG mRNA
nickel sulfate affects the expression of IFNG mRNA

PMID:10929769 PMID:11145678 PMID:14650623 PMID:15270870 PMID:15663561 More...

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interferon-related developmental regulator 1

increases expression

nickel sulfate results in increased expression of IFRD1 mRNA

NCBI chr12:40,253,128...40,273,184
Ensembl chr12:40,251,566...40,298,503

G

intraflagellar transport 56

increases expression

nickel sulfate results in increased expression of IFT56 mRNA

NCBI chr 6:38,358,400...38,404,582
Ensembl chr 6:38,358,404...38,404,582

G

intraflagellar transport 70A1

increases expression

nickel sulfate results in increased expression of IFT70A mRNA

NCBI chr 2:75,809,450...75,812,311
Ensembl chr 2:75,808,591...75,812,311

G

intraflagellar transport 88

decreases expression

nickel sulfate results in decreased expression of IFT88 mRNA

NCBI chr14:57,661,519...57,755,393
Ensembl chr14:57,661,519...57,755,393

G

insulin-like growth factor 2 mRNA binding protein 1

decreases expression

nickel sulfate results in decreased expression of IGF2BP1 mRNA

NCBI chr11:95,847,989...95,896,770
Ensembl chr11:95,847,989...95,896,766

G

insulin-like growth factor binding protein 4

decreases expression

nickel sulfate results in decreased expression of IGFBP4 mRNA

NCBI chr11:98,930,820...98,943,481
Ensembl chr11:98,932,070...98,945,218

G

insulin-like growth factor binding protein 6

decreases expression
increases expression

nickel sulfate results in decreased expression of IGFBP6 mRNA
nickel sulfate results in increased expression of IGFBP6 mRNA

PMID:16100012 PMID:16780908 PMID:17374397

NCBI chr15:102,052,621...102,057,947
Ensembl chr15:102,052,797...102,057,946

G

interleukin 10

increases secretion
increases expression

nickel sulfate results in increased secretion of IL10 protein
nickel sulfate results in increased expression of IL10 mRNA

PMID:11145678 PMID:15347381

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 11

decreases expression

nickel sulfate results in decreased expression of IL11 mRNA

NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858

G

interleukin 12a

increases expression

nickel sulfate results in increased expression of IL12A mRNA

NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880

G

interleukin 12b

affects expression
multiple interactions
increases secretion
increases expression

nickel sulfate affects the expression of IL12B mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [nickel sulfate results in increased secretion of IL12B protein]; BAY 11-7085 inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein]
nickel sulfate results in increased expression of IL12B mRNA; nickel sulfate results in increased expression of IL12B protein

PMID:17636246 PMID:18202158 PMID:19101624 PMID:20525893 PMID:25673294 More...

NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860

G

interleukin 13 receptor, alpha 1

increases expression

nickel sulfate results in increased expression of IL13RA1 mRNA

NCBI chr X:35,375,761...35,434,915
Ensembl chr X:35,375,763...35,434,912

G

interleukin 15

affects expression

nickel sulfate affects the expression of IL15 mRNA

NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851

G

interleukin 18

decreases expression
increases expression

nickel sulfate results in decreased expression of IL18 mRNA
nickel sulfate results in increased expression of IL18 protein

PMID:18651567 PMID:23063874

NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140

G

interleukin 1 alpha

increases secretion
multiple interactions

nickel sulfate results in increased secretion of IL1A protein
IL1A protein affects the reaction [nickel sulfate results in increased secretion of CCL20 protein]; IL1A protein affects the reaction [nickel sulfate results in increased secretion of CXCL8 protein]

NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892

G

interleukin 1 beta

increases expression
increases secretion
multiple interactions
decreases expression

nickel sulfate results in increased expression of IL1B mRNA
nickel sulfate results in increased secretion of IL1B protein
[Tetradecanoylphorbol Acetate co-treated with nickel sulfate] results in increased expression of and results in increased secretion of IL1B protein; Zinc Sulfate inhibits the reaction [nickel sulfate results in increased secretion of IL1B protein]
nickel sulfate results in increased expression of IL1B mRNA; nickel sulfate results in increased expression of IL1B protein
Quercetin inhibits the reaction [nickel sulfate results in increased expression of IL1B protein]
nickel sulfate results in decreased expression of IL1B mRNA

PMID:11033066 PMID:11114790 PMID:11751209 PMID:14650623 PMID:16166746 More...

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 1 receptor, type I

increases expression

nickel sulfate results in increased expression of IL1R1 mRNA

NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417

G

interleukin 1 receptor, type II

increases expression

nickel sulfate results in increased expression of IL1R2 mRNA

PMID:16166746 PMID:16780908

NCBI chr 1:40,123,872...40,164,390
Ensembl chr 1:40,113,239...40,164,391

G

interleukin 1 receptor antagonist

increases expression

nickel sulfate results in increased expression of IL1RN mRNA

PMID:16166746 PMID:16780908

NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506

G

interleukin 2

increases secretion
increases expression
multiple interactions

nickel sulfate results in increased secretion of IL2 protein
nickel sulfate results in increased expression of IL2 protein
[nickel sulfate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA

PMID:12925207 PMID:22381623 PMID:29594315

NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108

G

interleukin 23, alpha subunit p19

increases expression

nickel sulfate results in increased expression of IL23A mRNA

NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621

G

interleukin 24

decreases expression

nickel sulfate results in decreased expression of IL24 mRNA

NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191

G

interleukin 27

increases expression
multiple interactions

nickel sulfate results in increased expression of IL27 mRNA
BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of IL27 mRNA]; IFNG protein promotes the reaction [nickel sulfate results in increased expression of IL27 mRNA]; Janus Kinase Inhibitors inhibits the reaction [nickel sulfate results in increased secretion of IL27 mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in increased expression of IL27 mRNA]; TLR4 protein affects the reaction [nickel sulfate results in increased expression of IL27 mRNA]

NCBI chr 7:126,188,181...126,194,197
Ensembl chr 7:126,188,182...126,194,113

G

interleukin 4

increases secretion
increases expression

nickel sulfate results in increased secretion of IL4 protein
nickel sulfate results in increased expression of IL4 mRNA

PMID:10929769 PMID:11145678

NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496

G

interleukin 4 receptor, alpha

increases expression

nickel sulfate results in increased expression of IL4RA mRNA; nickel sulfate results in increased expression of IL4RA protein

PMID:16100012 PMID:22381623

NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646

G

interleukin 5

multiple interactions
increases secretion

Cyclosporine inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein]; Diclofenac inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein]; Hydrocortisone inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein]

PMID:10929769 PMID:15270870 PMID:15347381 PMID:15663561 PMID:19572476

NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933

G

interleukin 6

increases expression
multiple interactions
increases secretion

nickel sulfate results in increased expression of IL6 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of IL6 mRNA; [nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of IL6 mRNA; [nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein; [Tetradecanoylphorbol Acetate co-treated with nickel sulfate] results in increased expression of and results in increased secretion of IL6 protein; BAY 11-7085 inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; HIF1A mRNA affects the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; nickel sulfate results in increased expression of and results in increased secretion of IL6 protein; PTGS2 mRNA affects the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; U 0126 inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; U 0126 inhibits the reaction [nickel sulfate results in increased expression of IL6 protein]
nickel sulfate results in increased expression of IL6 mRNA; nickel sulfate results in increased expression of IL6 protein
puerarin inhibits the reaction [nickel sulfate results in increased expression of IL6 protein]

PMID:11033066 PMID:11114790 PMID:16166746 PMID:16780908 PMID:17118622 More...

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

interleukin 7 receptor

increases expression

nickel sulfate results in increased expression of IL7R mRNA

PMID:16780908 PMID:22714537

NCBI chr15:9,505,880...9,530,270
Ensembl chr15:9,505,874...9,530,262

G

immunoglobulin-like domain containing receptor 2

decreases expression

nickel sulfate results in decreased expression of ILDR2 mRNA

NCBI chr 1:166,081,630...166,144,405
Ensembl chr 1:166,081,708...166,144,392

G

inflammation and lipid regulator with UBA-like and NBR1-like domains

increases expression

nickel sulfate results in increased expression of ILRUN mRNA

NCBI chr17:27,970,206...28,039,516
Ensembl chr17:27,970,209...28,039,622

G

inositol monophosphatase 2

increases expression

nickel sulfate results in increased expression of IMPA2 mRNA

NCBI chr18:67,422,246...67,454,375
Ensembl chr18:67,422,256...67,455,542

G

inhibin beta-A

increases expression

nickel sulfate results in increased expression of INHBA mRNA

NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206

G

insulin induced gene 2

increases expression

nickel sulfate results in increased expression of INSIG2 mRNA

NCBI chr 1:121,232,082...121,260,391
Ensembl chr 1:121,232,082...121,260,318

G

insulinoma-associated 1

increases expression

nickel sulfate results in increased expression of INSM1 mRNA

NCBI chr 2:146,064,021...146,066,940
Ensembl chr 2:146,063,841...146,066,940

G

integrator complex subunit 2

increases expression

nickel sulfate results in increased expression of INTS2 mRNA

NCBI chr11:86,101,507...86,148,912
Ensembl chr11:86,101,507...86,148,401

G

interaction protein for cytohesin exchange factors 1

decreases expression

nickel sulfate results in decreased expression of IPCEF1 mRNA

PMID:16780908 PMID:17374397

NCBI chr10:6,835,779...6,973,185
Ensembl chr10:6,835,796...7,002,478

G

IQ motif containing K

increases expression

nickel sulfate results in increased expression of IQCK mRNA

NCBI chr 7:118,454,975...118,571,343
Ensembl chr 7:118,454,975...118,571,875

G

IQ motif containing GTPase activating protein 2

increases expression

nickel sulfate results in increased expression of IQGAP2 mRNA

NCBI chr13:95,763,685...96,028,788
Ensembl chr13:95,763,682...96,028,991

G

interferon regulatory factor 1

increases expression
multiple interactions

nickel sulfate results in increased expression of IRF1 mRNA; nickel sulfate results in increased expression of IRF1 protein
Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of IRF1 protein]; Puromycin inhibits the reaction [nickel sulfate results in increased expression of IRF1 protein]

NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200

G

interferon regulatory factor 5

increases expression

nickel sulfate results in increased expression of IRF5 mRNA

NCBI chr 6:29,526,129...29,541,874
Ensembl chr 6:29,526,624...29,541,870

G

interferon regulatory factor 8

increases expression

nickel sulfate results in increased expression of IRF8 mRNA

NCBI chr 8:121,463,097...121,483,433
Ensembl chr 8:121,463,097...121,483,433

G

Iroquois homeobox 4

increases expression

nickel sulfate results in increased expression of IRX4 mRNA

NCBI chr13:73,407,708...73,417,741
Ensembl chr13:73,408,598...73,417,727

G

Iroquois homeobox 5

decreases expression

nickel sulfate results in decreased expression of IRX5 mRNA

NCBI chr 8:93,084,424...93,088,084
Ensembl chr 8:93,084,253...93,102,914

G

myo-inositol 1-phosphate synthase A1

decreases expression

nickel sulfate results in decreased expression of ISYNA1 mRNA

NCBI chr 8:71,047,131...71,049,940
Ensembl chr 8:71,047,023...71,049,940

G

integrin alpha 7

decreases expression

nickel sulfate results in decreased expression of ITGA7 mRNA

NCBI chr10:128,769,633...128,794,155
Ensembl chr10:128,769,645...128,794,155

G

integrin beta 3

increases expression

nickel sulfate results in increased expression of ITGB3 mRNA

NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302

G

integrin beta 4

increases expression

nickel sulfate results in increased expression of ITGB4 mRNA

PMID:18651567 PMID:22714537

NCBI chr11:115,865,556...115,899,238
Ensembl chr11:115,865,535...115,899,238

G

inosine triphosphatase (nucleoside triphosphate pyrophosphatase)

decreases expression

nickel sulfate results in decreased expression of ITPA mRNA

NCBI chr 2:130,506,702...130,523,534
Ensembl chr 2:130,509,530...130,523,534

G

inositol 1,4,5-triphosphate receptor 3

increases expression

nickel sulfate results in increased expression of ITPR3 mRNA

NCBI chr17:27,275,976...27,341,197
Ensembl chr17:27,276,278...27,341,197

G

ITPR interacting domain containing 2

increases expression

nickel sulfate results in increased expression of ITPRID2 mRNA

NCBI chr 2:79,419,207...79,503,310
Ensembl chr 2:79,465,696...79,503,310

G

influenza virus NS1A binding protein

decreases expression

nickel sulfate results in decreased expression of IVNS1ABP mRNA

NCBI chr 1:151,220,237...151,240,196
Ensembl chr 1:151,220,228...151,240,173

G

junctional cadherin complex regulator

increases expression

nickel sulfate results in increased expression of JHY mRNA

NCBI chr 9:40,806,147...40,877,560
Ensembl chr 9:40,806,145...40,875,414

G

jumonji domain containing 6

increases expression

nickel sulfate results in increased expression of JMJD6 mRNA

NCBI chr11:116,728,258...116,734,593
Ensembl chr11:116,728,258...116,734,275

G

jumonji domain containing 8

decreases expression

nickel sulfate results in decreased expression of JMJD8 mRNA

NCBI chr17:26,048,017...26,050,817
Ensembl chr17:26,047,841...26,050,817

G

Jrk-like

decreases expression

nickel sulfate results in decreased expression of JRKL mRNA

NCBI chr 9:13,242,795...13,245,746
Ensembl chr 9:13,242,612...13,245,834

G

jun proto-oncogene

increases activity
increases expression
multiple interactions
increases phosphorylation

nickel sulfate results in increased activity of JUN protein
nickel sulfate results in increased expression of JUN mRNA
Potassium Dichromate inhibits the reaction [nickel sulfate results in increased phosphorylation of JUN protein]

PMID:16314067 PMID:17382205 PMID:19131640 PMID:20493934

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

jun B proto-oncogene

increases expression

nickel sulfate results in increased expression of JUNB mRNA

PMID:16166746 PMID:16780908 PMID:18651567 PMID:19131640

NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347

G

jun D proto-oncogene

increases expression

nickel sulfate results in increased expression of JUND mRNA

NCBI chr 8:71,150,389...71,153,265
Ensembl chr 8:71,151,599...71,153,265

G

junction plakoglobin

decreases expression

nickel sulfate results in decreased expression of JUP mRNA

NCBI chr11:100,259,682...100,288,639
Ensembl chr11:100,259,784...100,288,589

G

lysine acetyltransferase 14

decreases expression

nickel sulfate results in decreased expression of KAT14 mRNA

NCBI chr 2:144,210,952...144,249,595
Ensembl chr 2:144,210,903...144,249,596

G

potassium voltage-gated channel, subfamily G, member 1

increases expression

nickel sulfate results in increased expression of KCNG1 mRNA

NCBI chr 2:168,102,037...168,123,453
Ensembl chr 2:168,102,037...168,123,656

G

potassium voltage-gated channel, subfamily G, member 3

increases expression

nickel sulfate results in increased expression of KCNG3 mRNA

NCBI chr17:83,881,452...83,939,595
Ensembl chr17:83,893,386...83,939,324

G

potassium inwardly-rectifying channel, subfamily J, member 10

decreases expression

nickel sulfate results in decreased expression of KCNJ10 mRNA

NCBI chr 1:172,168,777...172,201,652
Ensembl chr 1:172,168,777...172,201,652

G

potassium inwardly-rectifying channel, subfamily J, member 2

decreases expression

nickel sulfate results in decreased expression of KCNJ2 mRNA

PMID:16780908 PMID:17374397

NCBI chr11:110,956,990...110,967,651
Ensembl chr11:110,956,990...110,967,647

G

potassium channel tetramerisation domain containing 13

increases expression

nickel sulfate results in increased expression of KCTD13 mRNA

NCBI chr 7:126,528,051...126,544,781
Ensembl chr 7:126,528,051...126,544,803

G

potassium channel tetramerisation domain containing 15

decreases expression

nickel sulfate results in decreased expression of KCTD15 mRNA

NCBI chr 7:34,336,424...34,354,934
Ensembl chr 7:34,338,439...34,356,157

G

potassium channel tetramerisation domain containing 4

decreases expression

nickel sulfate results in decreased expression of KCTD4 mRNA

NCBI chr14:76,192,443...76,202,657
Ensembl chr14:76,192,449...76,203,646

G

lysine (K)-specific demethylase 3A

increases expression

nickel sulfate results in increased expression of KDM3A protein

NCBI chr 6:71,565,954...71,609,963
Ensembl chr 6:71,565,956...71,609,974

G

kinesin family member 16B

decreases expression

nickel sulfate results in decreased expression of KIF16B mRNA

NCBI chr 2:142,459,399...142,743,535
Ensembl chr 2:142,459,394...142,743,451

G

kinesin family member 1B

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of KIF1B mRNA

NCBI chr 4:149,260,776...149,392,762
Ensembl chr 4:149,260,776...149,392,150

G

kinesin family member 20B

decreases expression

nickel sulfate results in decreased expression of KIF20B mRNA

NCBI chr19:34,899,735...34,953,150
Ensembl chr19:34,899,761...34,953,145

G

kinesin family member 5C

increases expression

nickel sulfate results in increased expression of KIF5C mRNA

NCBI chr 2:49,509,298...49,664,790
Ensembl chr 2:49,509,310...49,664,790

G

kinesin-associated protein 3

decreases expression

nickel sulfate results in decreased expression of KIFAP3 mRNA

NCBI chr 1:163,589,711...163,744,676
Ensembl chr 1:163,607,152...163,744,678

G

kirre like nephrin family adhesion molecule 3

decreases expression

nickel sulfate results in decreased expression of KIRREL3 mRNA

NCBI chr 9:34,396,850...34,952,103
Ensembl chr 9:34,397,190...34,948,012

G

KIT proto-oncogene receptor tyrosine kinase

decreases expression

nickel sulfate results in decreased expression of KIT mRNA

NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382

G

kit ligand

decreases expression

nickel sulfate results in decreased expression of KITLG mRNA

NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278

G

kizuna centrosomal protein

decreases expression

nickel sulfate results in decreased expression of KIZ mRNA

NCBI chr 2:146,697,743...146,812,018
Ensembl chr 2:146,697,784...146,812,017

G

klotho beta

decreases expression

nickel sulfate results in decreased expression of KLB mRNA

NCBI chr 5:65,505,754...65,544,300
Ensembl chr 5:65,505,657...65,541,350

G

Kruppel-like transcription factor 11

increases expression

nickel sulfate results in increased expression of KLF11 mRNA

NCBI chr12:24,701,370...24,712,781
Ensembl chr12:24,701,273...24,712,788

G

Kruppel-like transcription factor 4 (gut)

decreases expression

nickel sulfate results in decreased expression of KLF4 mRNA

NCBI chr 4:55,527,137...55,536,984
Ensembl chr 4:55,527,143...55,532,466

G

Kruppel-like transcription factor 6

increases expression

nickel sulfate results in increased expression of KLF6 mRNA

PMID:16314067 PMID:17374397

NCBI chr13:5,911,488...5,920,392
Ensembl chr13:5,911,481...5,920,393

G

kelch-like 36

increases expression

nickel sulfate results in increased expression of KLHL36 mRNA

NCBI chr 8:120,588,970...120,603,728
Ensembl chr 8:120,589,005...120,603,734

G

kallikrein related-peptidase 10

increases expression

nickel sulfate results in increased expression of KLK10 mRNA

NCBI chr 7:43,430,478...43,434,834
Ensembl chr 7:43,430,459...43,434,834

G

kallikrein related-peptidase 8

decreases activity

nickel sulfate results in decreased activity of KLK8 protein

NCBI chr 7:43,447,001...43,453,250
Ensembl chr 7:43,447,001...43,453,250

G

kringle containing transmembrane protein 1

increases expression

nickel sulfate results in increased expression of KREMEN1 mRNA

NCBI chr11:5,141,551...5,212,220
Ensembl chr11:5,141,552...5,211,558

G

KRR1, small subunit (SSU) processome component, homolog (yeast)

decreases expression

nickel sulfate results in decreased expression of KRR1 mRNA

NCBI chr10:111,808,600...111,824,335
Ensembl chr10:111,808,569...111,824,337

G

keratin 17

decreases expression

nickel sulfate results in decreased expression of KRT17 mRNA

NCBI chr11:100,147,041...100,151,855
Ensembl chr11:100,147,043...100,151,855

G

keratin 7

affects expression

nickel sulfate affects the expression of KRT7 mRNA

NCBI chr15:101,310,284...101,325,687
Ensembl chr15:101,308,924...101,328,194

G

kynureninase

increases expression

nickel sulfate results in increased expression of KYNU mRNA

NCBI chr 2:43,445,270...43,572,734
Ensembl chr 2:43,445,341...43,572,734

G

ladinin

increases expression

nickel sulfate results in increased expression of LAD1 mRNA

NCBI chr 1:135,746,336...135,761,079
Ensembl chr 1:135,746,336...135,761,080

G

laminin, alpha 4

increases expression

nickel sulfate results in increased expression of LAMA4 mRNA

NCBI chr10:38,841,511...38,986,184
Ensembl chr10:38,841,511...38,986,184

G

laminin, beta 3

decreases expression

nickel sulfate results in decreased expression of LAMB3 mRNA

NCBI chr 1:192,976,661...193,026,186
Ensembl chr 1:192,890,007...193,026,186

G

laminin, gamma 1

decreases expression

nickel sulfate results in decreased expression of LAMC1 mRNA

NCBI chr 1:153,094,668...153,208,532
Ensembl chr 1:153,094,668...153,208,532

G

laminin, gamma 2

decreases expression

nickel sulfate results in decreased expression of LAMC2 mRNA

NCBI chr 1:152,998,502...153,062,193
Ensembl chr 1:152,998,502...153,062,193

G

lysosomal-associated membrane protein 3

increases expression

nickel sulfate results in increased expression of LAMP3 mRNA

PMID:16780908 PMID:22714537

NCBI chr16:19,472,131...19,525,115
Ensembl chr16:19,472,128...19,525,125

G

lamin B receptor

decreases expression

nickel sulfate results in decreased expression of LBR mRNA

NCBI chr 1:181,642,880...181,669,933
Ensembl chr 1:181,642,900...181,670,611

G

lipocalin 2

increases expression

nickel sulfate results in increased expression of LCN2 mRNA

NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264

G

leptin

multiple interactions
increases expression

[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of LEP mRNA
nickel sulfate results in increased expression of LEP mRNA

NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876

G

leptin receptor

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of LEPR mRNA

NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549

G

lectin, galactose binding, soluble 3

affects expression
decreases expression

nickel sulfate affects the expression of LGALS3 mRNA
nickel sulfate results in decreased expression of LGALS3 mRNA

PMID:12718980 PMID:18651567

NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617

G

lectin, galactose binding, soluble 8

decreases expression

nickel sulfate results in decreased expression of LGALS8 mRNA

NCBI chr13:12,454,283...12,479,857
Ensembl chr13:12,454,296...12,479,825

G

LIM homeobox protein 2

increases expression

nickel sulfate results in increased expression of LHX2 mRNA

NCBI chr 2:38,229,282...38,259,747
Ensembl chr 2:38,229,293...38,259,745

G

leukemia inhibitory factor

decreases expression

nickel sulfate results in decreased expression of LIF mRNA

NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514

G

LIF receptor alpha

increases expression

nickel sulfate results in increased expression of LIFR mRNA

NCBI chr15:7,120,091...7,226,970
Ensembl chr15:7,120,095...7,226,970

G

ligase I, DNA, ATP-dependent

increases expression

nickel sulfate results in increased expression of LIG1 mRNA

NCBI chr 7:13,011,101...13,045,351
Ensembl chr 7:13,011,239...13,045,350

G

leukocyte immunoglobulin-like receptor, subfamily B, member 4B

increases expression

nickel sulfate results in increased expression of LILRB4 mRNA; nickel sulfate results in increased expression of LILRB4B mRNA

NCBI chr10:51,356,757...51,362,417
Ensembl chr10:51,356,728...51,362,799

G

lines homolog 1

decreases expression

nickel sulfate results in decreased expression of LINS1 mRNA

NCBI chr 7:66,339,565...66,367,004
Ensembl chr 7:66,339,637...66,367,004

G

lipase, member H

increases expression

nickel sulfate results in increased expression of LIPH mRNA

NCBI chr16:21,772,567...21,814,408
Ensembl chr16:21,772,567...21,814,413

G

LPS-induced TN factor

increases expression
decreases expression

nickel sulfate results in increased expression of LITAF mRNA
nickel sulfate results in decreased expression of LITAF mRNA

PMID:16100012 PMID:18651567

NCBI chr16:10,777,137...10,810,985
Ensembl chr16:10,777,139...10,884,021

G

LLGL2 scribble cell polarity complex component

increases expression

nickel sulfate results in increased expression of LLGL2 mRNA

NCBI chr11:115,714,855...115,746,606
Ensembl chr11:115,714,875...115,746,606

G

limb region 1

decreases expression

nickel sulfate results in decreased expression of LMBR1 mRNA

NCBI chr 5:29,434,800...29,583,414
Ensembl chr 5:29,481,000...29,485,295
Ensembl chr 5:29,481,000...29,485,295

G

LIM homeobox transcription factor 1 beta

increases expression

nickel sulfate results in increased expression of LMX1B mRNA

NCBI chr 2:33,450,977...33,531,219
Ensembl chr 2:33,450,977...33,530,620

G

lysyl oxidase

increases expression
decreases expression

nickel sulfate results in increased expression of LOX mRNA
nickel sulfate results in decreased expression of LOX mRNA

PMID:17382205 PMID:22714537

NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939

G

lysophosphatidic acid receptor 3

increases expression

nickel sulfate results in increased expression of LPAR3 mRNA

NCBI chr 3:145,926,716...145,991,969
Ensembl chr 3:145,926,718...145,991,941

G

lysophosphatidic acid receptor 6

decreases expression

nickel sulfate results in decreased expression of LPAR6 mRNA

NCBI chr14:73,475,331...73,477,798
Ensembl chr14:73,475,335...73,480,734

G

lysophosphatidylcholine acyltransferase 1

increases expression

nickel sulfate results in increased expression of LPCAT1 mRNA

NCBI chr13:73,615,332...73,664,539
Ensembl chr13:73,615,316...73,664,541

G

lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)

decreases expression

nickel sulfate results in decreased expression of LRAT mRNA

NCBI chr 3:82,799,889...82,811,281
Ensembl chr 3:82,799,886...82,811,280

G

leucine-rich repeats and immunoglobulin-like domains 3

increases expression

nickel sulfate results in increased expression of LRIG3 mRNA

NCBI chr10:125,802,088...125,851,228
Ensembl chr10:125,802,037...125,851,228

G

low density lipoprotein-related protein 12

decreases expression

nickel sulfate results in decreased expression of LRP12 mRNA

NCBI chr15:39,733,985...39,807,417
Ensembl chr15:39,733,985...39,807,390

G

leucine-rich repeat kinase 1

increases expression

nickel sulfate results in increased expression of LRRK1 mRNA

NCBI chr 7:65,908,493...66,038,089
Ensembl chr 7:65,876,660...66,038,098

G

lymphocyte specific 1

decreases expression

nickel sulfate results in decreased expression of LSP1 mRNA

NCBI chr 7:142,014,583...142,048,605
Ensembl chr 7:142,014,546...142,048,604

G

lipolysis stimulated lipoprotein receptor

increases expression

nickel sulfate results in increased expression of LSR mRNA

NCBI chr 7:30,657,195...30,672,894
Ensembl chr 7:30,657,195...30,672,889

G

latent transforming growth factor beta binding protein 2

decreases expression

nickel sulfate results in decreased expression of LTBP2 mRNA

NCBI chr12:84,829,986...84,923,581
Ensembl chr12:84,829,986...84,923,306

G

LUC7-like 3 (S. cerevisiae)

decreases expression

nickel sulfate results in decreased expression of CROP mRNA

NCBI chr11:94,181,899...94,213,196
Ensembl chr11:94,178,716...94,212,814

G

leucine rich adaptor protein 1-like

increases expression

nickel sulfate results in increased expression of LURAP1L mRNA

NCBI chr 4:80,828,923...80,872,538
Ensembl chr 4:80,828,883...80,873,865

G

LYN proto-oncogene, Src family tyrosine kinase

increases expression

nickel sulfate results in increased expression of LYN mRNA

NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122

G

Ly6/Plaur domain containing 1

increases expression

nickel sulfate results in increased expression of LYPD1 mRNA

NCBI chr 1:125,795,359...125,841,134
Ensembl chr 1:125,795,359...125,840,838

G

LY6/PLAUR domain containing 6

increases expression

nickel sulfate results in increased expression of LYPD6 mRNA

NCBI chr 2:49,956,413...50,083,576
Ensembl chr 2:49,956,441...50,083,581

G

LY6/PLAUR domain containing 6B

increases expression

nickel sulfate results in increased expression of LYPD6B mRNA

NCBI chr 2:49,677,380...49,838,861
Ensembl chr 2:49,677,700...49,838,861

G

MAF bZIP transcription factor

decreases expression

nickel sulfate results in decreased expression of MAF mRNA

NCBI chr 8:116,429,992...116,433,633
Ensembl chr 8:116,409,681...116,434,533

G

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)

increases expression

nickel sulfate results in increased expression of MAFF mRNA

PMID:16166746 PMID:18651567 PMID:20566472

NCBI chr15:79,230,813...79,243,278
Ensembl chr15:79,230,821...79,243,276

G

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)

increases expression

nickel sulfate results in increased expression of MAFG mRNA

NCBI chr11:120,515,943...120,525,771
Ensembl chr11:120,515,943...120,524,426

G

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)

increases expression

nickel sulfate results in increased expression of MAFK mRNA

PMID:17374397 PMID:20566472

NCBI chr 5:139,777,291...139,788,409
Ensembl chr 5:139,777,268...139,788,408

G

MAGE family member F1

decreases expression

nickel sulfate results in decreased expression of MAGEF1 mRNA

NCBI chr16:21,150,650...21,152,106
Ensembl chr16:21,151,396...21,151,879
Ensembl chr16:21,151,396...21,151,879

G

membrane associated guanylate kinase, WW and PDZ domain containing 1

decreases expression

nickel sulfate results in decreased expression of MAGI1 mRNA

NCBI chr 6:93,652,434...94,260,906
Ensembl chr 6:93,652,436...94,260,898

G

membrane associated guanylate kinase, WW and PDZ domain containing 3

decreases expression

nickel sulfate results in decreased expression of MAGI3 mRNA

NCBI chr 3:103,920,575...104,127,722
Ensembl chr 3:103,920,575...104,127,690

G

mastermind-like domain containing 1

decreases expression

nickel sulfate results in decreased expression of MAMLD1 mRNA

NCBI chr X:70,093,642...70,199,662
Ensembl chr X:70,093,846...70,199,662

G

mannosidase 2, alpha 1

decreases expression

nickel sulfate results in decreased expression of MAN2A1 mRNA

NCBI chr17:64,907,683...65,062,105
Ensembl chr17:64,907,731...65,062,105

G

monoamine oxidase A

increases expression

nickel sulfate results in increased expression of MAOA mRNA

NCBI chr X:16,485,937...16,554,051
Ensembl chr X:16,485,937...16,554,057

G

mitogen-activated protein kinase kinase 3

increases phosphorylation

nickel sulfate results in increased phosphorylation of MAP2K3 protein

NCBI chr11:60,822,880...60,843,637
Ensembl chr11:60,822,859...60,843,637

G

mitogen-activated protein kinase kinase 7

increases phosphorylation

nickel sulfate results in increased phosphorylation of MAP2K7 protein

NCBI chr 8:4,288,740...4,297,897
Ensembl chr 8:4,288,740...4,297,897
Ensembl chr 8:4,288,740...4,297,897

G

mitogen-activated protein kinase kinase kinase 1

affects response to substance
multiple interactions
decreases expression

MAP3K1 protein affects the susceptibility to nickel sulfate
[MAP3K1 protein co-treated with MAP3K2 protein] affects the susceptibility to nickel sulfate; MAP3K1 protein affects the reaction [nickel sulfate results in increased phosphorylation of MAPK8 protein]
nickel sulfate results in decreased expression of MAP3K1 mRNA

PMID:18467339 PMID:22714537

NCBI chr13:111,882,962...111,954,803
Ensembl chr13:111,882,962...111,945,527

G

mitogen-activated protein kinase kinase kinase 14

increases expression

nickel sulfate results in increased expression of MAP3K14 mRNA

NCBI chr11:103,110,590...103,158,227
Ensembl chr11:103,110,588...103,158,298

G

mitogen-activated protein kinase kinase kinase 2

multiple interactions

[MAP3K1 protein co-treated with MAP3K2 protein] affects the susceptibility to nickel sulfate

NCBI chr18:32,296,142...32,369,804
Ensembl chr18:32,296,142...32,369,804

G

mitogen-activated protein kinase kinase kinase 5

increases expression

nickel sulfate results in increased expression of MAP3K5 mRNA

NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499

G

Map3k7 C-terminal like

increases expression

nickel sulfate results in increased expression of MAP3K7CL mRNA

NCBI chr16:87,350,208...87,392,224
Ensembl chr16:87,350,218...87,392,224

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation

[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased phosphorylation of MAPK1 protein; U 0126 inhibits the reaction [nickel sulfate results in increased phosphorylation of MAPK1 protein]

PMID:15588916 PMID:18495191 PMID:19101624 PMID:19135467 PMID:20600219 More...

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 13

decreases expression

nickel sulfate results in decreased expression of MAPK13 mRNA

NCBI chr17:28,988,260...28,997,678
Ensembl chr17:28,988,271...28,999,207

G

mitogen-activated protein kinase 14

multiple interactions
increases phosphorylation

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of MAPK14 mRNA
nickel sulfate results in increased phosphorylation of MAPK14 protein

PMID:31734292 PMID:35499276

NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380

G

mitogen-activated protein kinase 3

multiple interactions
increases phosphorylation

[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased phosphorylation of MAPK3 protein; U 0126 inhibits the reaction [nickel sulfate results in increased phosphorylation of MAPK3 protein]

PMID:15588916 PMID:18495191 PMID:19101624 PMID:19135467 PMID:20600219 More...

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

pyrazolanthrone inhibits the reaction [nickel sulfate results in increased phosphorylation of MAPK8 protein]; SB 203580 promotes the reaction [nickel sulfate results in increased phosphorylation of MAPK8 protein]
MAP3K1 protein affects the reaction [nickel sulfate results in increased phosphorylation of MAPK8 protein]

PMID:15588916 PMID:18467339 PMID:18495191 PMID:19101624 PMID:35499276

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

mitogen-activated protein kinase 9

increases phosphorylation

nickel sulfate results in increased phosphorylation of MAPK9 protein

PMID:15588916 PMID:19101624

NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248

G

MAP kinase-activated protein kinase 2

multiple interactions

[Potassium Dichromate co-treated with nickel sulfate] results in increased phosphorylation of MAPKAPK2 protein

NCBI chr 1:130,981,437...131,025,580
Ensembl chr 1:130,981,437...131,025,563

G

mitogen-activated protein kinase-activated protein kinase 3

increases expression

nickel sulfate results in increased expression of MAPKAPK3 mRNA

NCBI chr 9:107,132,125...107,167,082
Ensembl chr 9:107,132,126...107,167,076

G

microtubule-associated protein tau

decreases expression

nickel sulfate results in decreased expression of MAPT mRNA

NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916

G

myristoylated alanine rich protein kinase C substrate

increases expression

nickel sulfate results in increased expression of MARCKS mRNA

NCBI chr10:37,009,239...37,014,922
Ensembl chr10:37,009,371...37,014,916

G

MARVEL (membrane-associating) domain containing 2

increases expression

nickel sulfate results in increased expression of MARVELD2 mRNA

NCBI chr13:100,732,465...100,753,479
Ensembl chr13:100,732,465...100,753,479

G

matrilin 3

increases expression

nickel sulfate results in increased expression of MATN3 mRNA

NCBI chr12:8,997,929...9,022,028
Ensembl chr12:8,997,929...9,022,028

G

membrane bound O-acyltransferase domain containing 1

increases expression

nickel sulfate results in increased expression of MBOAT1 mRNA

NCBI chr13:30,320,499...30,430,677
Ensembl chr13:30,320,472...30,430,700

G

mutated in colorectal cancers

decreases expression

nickel sulfate results in decreased expression of MCC mRNA

NCBI chr18:44,558,127...44,945,573
Ensembl chr18:44,558,127...44,945,249

G

minichromosome maintenance 8 homologous recombination repair factor

decreases expression

nickel sulfate results in decreased expression of MCM8 mRNA

NCBI chr 2:132,658,061...132,686,117
Ensembl chr 2:132,658,061...132,686,117

G

minichromosome maintenance 9 homologous recombination repair factor

increases expression

nickel sulfate results in increased expression of MCM9 mRNA

NCBI chr10:53,412,411...53,507,251
Ensembl chr10:53,412,411...53,506,535

G

mucolipin 2

increases expression

nickel sulfate results in increased expression of MCOLN2 mRNA

NCBI chr 3:145,855,552...145,901,269
Ensembl chr 3:145,855,588...145,901,268

G

mucolipin 3

increases expression

nickel sulfate results in increased expression of MCOLN3 mRNA

NCBI chr 3:145,799,032...145,847,563
Ensembl chr 3:145,823,205...145,847,561

G

multiple C2 domains, transmembrane 2

increases expression

nickel sulfate results in increased expression of MCTP2 mRNA

NCBI chr 7:71,727,575...71,956,850
Ensembl chr 7:71,727,578...71,956,356

G

mediator of DNA damage checkpoint 1

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of MDC1 mRNA

NCBI chr17:36,152,390...36,170,562
Ensembl chr17:36,152,407...36,170,562

G

MyoD family inhibitor

increases expression

nickel sulfate results in increased expression of MDFI mRNA

NCBI chr17:48,126,253...48,145,616
Ensembl chr17:48,126,253...48,145,616

G

MyoD family inhibitor domain containing

decreases expression

nickel sulfate results in decreased expression of MDFIC mRNA

NCBI chr 6:15,720,660...15,802,168
Ensembl chr 6:15,720,660...15,802,168

G

midkine

decreases expression

nickel sulfate results in decreased expression of MDK mRNA

NCBI chr 2:91,760,149...91,762,348
Ensembl chr 2:91,760,150...91,762,642

G

malic enzyme 1, NADP(+)-dependent, cytosolic

increases expression

nickel sulfate results in increased expression of ME1 mRNA

PMID:16314067 PMID:20566472

NCBI chr 9:86,463,416...86,577,967
Ensembl chr 9:86,463,424...86,578,006

G

mediator complex subunit 10

increases expression

nickel sulfate results in increased expression of MED10 mRNA

NCBI chr13:69,950,467...69,964,221
Ensembl chr13:69,950,514...69,964,223

G

mediator complex subunit 12-like

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of MED12L mRNA

NCBI chr 3:58,912,820...59,225,867
Ensembl chr 3:58,913,246...59,226,103

G

mediator complex subunit 22

increases expression

nickel sulfate results in increased expression of MED22 mRNA

NCBI chr 2:26,795,279...26,800,654
Ensembl chr 2:26,795,274...26,800,689

G

mediator complex subunit 4

decreases expression

nickel sulfate results in decreased expression of MED4 mRNA

NCBI chr14:73,747,489...73,755,985
Ensembl chr14:73,747,465...73,756,289

G

mesenteric estrogen dependent adipogenesis

decreases expression

nickel sulfate results in decreased expression of MEDAG mRNA

NCBI chr 5:149,335,214...149,355,188
Ensembl chr 5:149,335,214...149,355,188

G

myocyte enhancer factor 2C

decreases expression

nickel sulfate results in decreased expression of MEF2C mRNA

NCBI chr13:83,652,136...83,815,197
Ensembl chr13:83,652,153...83,815,199

G

Meis homeobox 2

increases expression

nickel sulfate results in increased expression of MEIS2 mRNA

NCBI chr 2:115,691,745...115,897,925
Ensembl chr 2:115,693,545...115,896,320

G

melanotransferrin

decreases expression

nickel sulfate results in decreased expression of MELTF mRNA

NCBI chr16:31,697,449...31,717,838
Ensembl chr16:31,697,628...31,717,838

G

mesoderm specific transcript

decreases expression

nickel sulfate results in decreased expression of MEST mRNA

NCBI chr 6:30,733,505...30,783,580
Ensembl chr 6:30,723,546...30,748,464

G

major facilitator superfamily domain containing 9

increases expression

nickel sulfate results in increased expression of MFSD9 mRNA

NCBI chr 1:40,811,200...40,829,817
Ensembl chr 1:40,811,198...40,829,847

G

mitochondria localized glutamic acid rich protein

increases expression

nickel sulfate results in increased expression of MGARP mRNA

NCBI chr 3:51,295,833...51,303,968
Ensembl chr 3:51,295,833...51,304,159

G

monoglyceride lipase

increases expression

nickel sulfate results in increased expression of MGLL mRNA

NCBI chr 6:88,701,397...88,805,342
Ensembl chr 6:88,701,394...88,805,342

G

mitochondrial genome maintenance exonuclease 1

decreases expression

nickel sulfate results in decreased expression of MGME1 mRNA

NCBI chr 2:144,112,824...144,123,147
Ensembl chr 2:144,112,583...144,123,147

G

microsomal glutathione S-transferase 1

increases expression

nickel sulfate results in increased expression of MGST1 mRNA

PMID:20566472 PMID:22714537

NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753

G

midline 1

decreases expression

nickel sulfate results in decreased expression of MID1 mRNA

NCBI chr X:168,468,178...168,773,692
Ensembl chr X:168,468,195...168,773,794

G

macrophage migration inhibitory factor (glycosylation-inhibiting factor)

increases expression

nickel sulfate results in increased expression of MIF mRNA

NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074

G

MIF4G domain containing

increases expression

nickel sulfate results in increased expression of MIF4GD mRNA

NCBI chr11:115,498,744...115,503,795
Ensembl chr11:115,498,744...115,503,795

G

microRNA 125b-1

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of MIR125B1 mRNA

NCBI chr 9:41,493,222...41,493,298
Ensembl chr 9:41,493,222...41,493,298

G

microRNA 130b

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of MIR130B mRNA

NCBI chr16:16,941,925...16,942,006
Ensembl chr16:16,941,925...16,942,006

G

microRNA 132

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of MIR132 mRNA

NCBI chr11:75,064,508...75,064,573
Ensembl chr11:75,064,508...75,064,573

G

microRNA 133b

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of MIR133B mRNA

NCBI chr 1:20,752,993...20,753,111
Ensembl chr 1:20,752,993...20,753,111

G

microRNA 139

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of MIR139 mRNA

NCBI chr 7:101,124,583...101,124,650
Ensembl chr 7:101,124,583...101,124,650

G

microRNA 147

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of MIR147 mRNA

NCBI chr 2:122,482,723...122,482,801
Ensembl chr 2:122,482,723...122,482,801

G

microRNA 154

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of MIR154 mRNA

NCBI chr12:109,704,867...109,704,932
Ensembl chr12:109,704,867...109,704,932

G

Mir155 host gene (non-protein coding)

decreases expression

nickel sulfate results in decreased expression of MIR155HG mRNA

NCBI chr16:84,509,911...84,512,133
Ensembl chr16:84,500,055...84,512,133

G

microRNA 181b-1

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of MIR181B1 mRNA

NCBI chr 1:137,894,377...137,894,456
Ensembl chr 1:137,894,377...137,894,456

G

microRNA 210

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of MIR210 mRNA

NCBI chr 7:140,801,297...140,801,406
Ensembl chr 7:140,801,297...140,801,406

G

microRNA 212

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of MIR212 mRNA

NCBI chr11:75,064,214...75,064,304
Ensembl chr11:75,064,214...75,064,304

G

microRNA 21a

increases expression

nickel sulfate results in increased expression of MIR21 mRNA

NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984

G

microRNA 23b

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of MIR23B mRNA

NCBI chr13:63,448,298...63,448,371
Ensembl chr13:63,448,298...63,448,371

G

microRNA 27a

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of MIR27A mRNA

NCBI chr 8:84,935,301...84,935,387
Ensembl chr 8:84,935,301...84,935,387

G

microRNA 32

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of MIR32 mRNA

NCBI chr 4:56,895,229...56,895,298
Ensembl chr 4:56,895,229...56,895,298

G

microRNA 320

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of MIR320A mRNA

NCBI chr14:70,680,950...70,681,031
Ensembl chr14:70,680,950...70,681,031

G

microRNA 322

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of MIR322 mRNA

NCBI chr X:52,143,132...52,143,226
Ensembl chr X:52,143,132...52,143,226

G

microRNA 503

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of MIR503 mRNA

NCBI chr X:52,142,861...52,142,931
Ensembl chr X:52,142,861...52,142,931

G

microRNA 708

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of MIR708 mRNA

NCBI chr 7:95,898,631...95,898,739
Ensembl chr 7:95,898,631...95,898,739

G

microRNA 760

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of MIR760 mRNA

NCBI chr 3:122,087,234...122,087,352
Ensembl chr 3:122,087,234...122,087,352

G

microRNA let7c-1

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of MIRLET7C1 mRNA

NCBI chr16:77,396,545...77,396,638
Ensembl chr16:77,396,545...77,396,638

G

melanogenesis associated transcription factor

increases expression

nickel sulfate results in increased expression of MITF mRNA

NCBI chr 6:97,783,966...97,998,321
Ensembl chr 6:97,784,013...97,998,310

G

antigen identified by monoclonal antibody Ki 67

increases expression

nickel sulfate results in increased expression of MKI67 protein

NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090

G

McKusick-Kaufman syndrome

decreases expression

nickel sulfate results in decreased expression of MKKS mRNA

NCBI chr 2:136,715,700...136,733,422
Ensembl chr 2:136,715,700...136,733,309

G

mohawk homeobox

increases expression

nickel sulfate results in increased expression of MKX mRNA

NCBI chr18:6,934,966...7,004,779
Ensembl chr18:6,934,518...7,004,780

G

myeloid leukemia factor 1

decreases expression

nickel sulfate results in decreased expression of MLF1 mRNA

NCBI chr 3:67,281,430...67,307,333
Ensembl chr 3:67,281,430...67,307,336

G

myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11

decreases expression

nickel sulfate results in decreased expression of MLLT11 mRNA

NCBI chr 3:95,125,852...95,139,486
Ensembl chr 3:95,126,446...95,139,482

G

myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3

decreases expression

nickel sulfate results in decreased expression of MLLT3 mRNA

NCBI chr 4:87,688,162...87,951,652
Ensembl chr 4:87,688,162...87,951,601

G

matrix metallopeptidase 10

increases expression

nickel sulfate results in increased expression of MMP10 mRNA

NCBI chr 9:7,502,343...7,510,243
Ensembl chr 9:7,502,353...7,510,241

G

matrix metallopeptidase 12

increases expression

nickel sulfate results in increased expression of MMP12 mRNA

NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499

G

matrix metallopeptidase 14 (membrane-inserted)

increases expression

nickel sulfate results in increased expression of MMP14 mRNA

NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821

G

matrix metallopeptidase 15

decreases expression

nickel sulfate results in decreased expression of MMP15 mRNA

NCBI chr 8:96,078,924...96,100,921
Ensembl chr 8:96,078,896...96,101,708

G

matrix metallopeptidase 16

decreases expression

nickel sulfate results in decreased expression of MMP16 mRNA

NCBI chr 4:17,853,072...18,117,479
Ensembl chr 4:17,852,893...18,119,145

G

matrix metallopeptidase 1b (interstitial collagenase)

increases expression

nickel sulfate results in increased expression of MMP1 mRNA

NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047

G

matrix metallopeptidase 2

increases secretion
increases expression

nickel sulfate results in increased secretion of MMP2 protein
nickel sulfate results in increased expression of MMP2 mRNA

PMID:15020194 PMID:18409814

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 24

decreases expression

nickel sulfate results in decreased expression of MMP24 mRNA

NCBI chr 2:155,617,262...155,660,286
Ensembl chr 2:155,617,262...155,660,286

G

matrix metallopeptidase 3

increases expression

nickel sulfate results in increased expression of MMP3 mRNA

PMID:16166746 PMID:16780908

NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975

G

matrix metallopeptidase 9

increases expression
multiple interactions

nickel sulfate results in increased expression of MMP9 mRNA
nickel sulfate results in increased expression of and results in increased secretion of MMP9 protein

PMID:15020194 PMID:18651567

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

meiosis-specific nuclear structural protein 1

increases expression

nickel sulfate results in increased expression of MNS1 mRNA

NCBI chr 9:72,345,276...72,366,036
Ensembl chr 9:72,345,293...72,369,307

G

monooxygenase, DBH-like 1

increases expression

nickel sulfate results in increased expression of MOXD1 mRNA

NCBI chr10:24,099,415...24,178,681
Ensembl chr10:24,099,415...24,178,688

G

M phase phosphoprotein 6

increases expression

nickel sulfate results in increased expression of MPHOSPH6 mRNA

NCBI chr 8:118,518,376...118,528,713
Ensembl chr 8:118,518,384...118,528,682

G

myeloperoxidase

decreases expression

nickel sulfate results in decreased expression of MPO mRNA

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

Mpv17 transgene, kidney disease mutant-like

decreases expression

nickel sulfate results in decreased expression of MPV17L mRNA

NCBI chr16:13,721,025...13,767,483
Ensembl chr16:13,721,025...13,767,483

G

myelin protein zero-like 1

decreases expression

nickel sulfate results in decreased expression of MPZL1 mRNA

NCBI chr 1:165,419,745...165,462,144
Ensembl chr 1:165,419,809...165,462,107

G

methylthioribose-1-phosphate isomerase 1

increases expression

nickel sulfate results in increased expression of MRI1 mRNA

NCBI chr 8:84,977,205...84,983,953
Ensembl chr 8:84,976,535...84,983,955

G

mitochondrial ribosomal protein L1

decreases expression

nickel sulfate results in decreased expression of MRPL1 mRNA

NCBI chr 5:96,357,357...96,414,586
Ensembl chr 5:96,357,352...96,414,586

G

mitochondrial ribosomal protein L12

increases expression

nickel sulfate results in increased expression of MRPL12 mRNA

NCBI chr11:120,375,463...120,379,580
Ensembl chr11:120,375,439...120,379,891

G

mitochondrial ribosomal protein L28

increases expression

nickel sulfate results in increased expression of MRPL28 mRNA

NCBI chr17:26,342,477...26,345,587
Ensembl chr17:26,342,474...26,345,587

G

mitochondrial ribosomal protein L35

decreases expression

nickel sulfate results in decreased expression of MRPL35 mRNA

NCBI chr 6:71,789,981...71,800,768
Ensembl chr 6:71,789,981...71,803,953

G

mitochondrial ribosomal protein S18B

increases expression

nickel sulfate results in increased expression of MRPS18B mRNA

NCBI chr17:36,221,272...36,227,332
Ensembl chr17:36,221,271...36,227,281

G

mitochondrial ribosomal protein S6

decreases expression

nickel sulfate results in decreased expression of MRPS6 mRNA

NCBI chr16:91,855,224...91,909,115
Ensembl chr16:91,855,158...91,909,115

G

membrane-spanning 4-domains, subfamily A, member 6C

decreases expression

nickel sulfate results in decreased expression of MS4A6A mRNA

NCBI chr19:11,446,718...11,464,433
Ensembl chr19:11,446,730...11,459,556

G

membrane-spanning 4-domains, subfamily A, member 7

increases expression

nickel sulfate results in increased expression of MS4A7 mRNA

PMID:16780908 PMID:17374397

NCBI chr19:11,298,403...11,313,510
Ensembl chr19:11,298,403...11,313,510

G

musculin

increases expression

nickel sulfate results in increased expression of MSC mRNA

NCBI chr 1:14,823,570...14,826,216
Ensembl chr 1:14,823,570...14,826,216

G

mesothelin

decreases expression

nickel sulfate results in decreased expression of MSLN mRNA

NCBI chr17:25,967,587...25,973,352
Ensembl chr17:25,967,587...25,973,352

G

beta-microseminoprotein

decreases expression

nickel sulfate results in decreased expression of MSMB mRNA

NCBI chr14:31,863,980...31,880,284
Ensembl chr14:31,863,980...31,880,327

G

macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

decreases expression
increases expression
multiple interactions
affects response to substance

nickel sulfate results in decreased expression of MST1R mRNA
nickel sulfate results in increased expression of MST1R mRNA
MST1R protein affects the reaction [nickel sulfate results in increased abundance of Nitrites]
MST1R protein affects the susceptibility to nickel sulfate

PMID:11751209 PMID:16166746 PMID:16780908

NCBI chr 9:107,784,057...107,797,582
Ensembl chr 9:107,784,072...107,797,582

G

metallothionein 1

affects expression
increases expression

nickel sulfate affects the expression of MT1 mRNA
nickel sulfate results in increased expression of MT1X mRNA
nickel sulfate results in increased expression of MT1A mRNA

PMID:12718980 PMID:19679144 PMID:20566472

NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955

G

metallothionein 2

increases expression

nickel sulfate results in increased expression of MT2 mRNA
nickel sulfate results in increased expression of MT2A mRNA

PMID:16100012 PMID:16314067 PMID:19131640 PMID:20491607

NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196

G

mitochondrial amidoxime reducing component 2

increases expression

nickel sulfate results in increased expression of MTARC2 mRNA

NCBI chr 1:184,545,263...184,579,266
Ensembl chr 1:184,545,265...184,578,648

G

metal response element binding transcription factor 1

increases activity
affects phosphorylation

nickel sulfate results in increased activity of MTF1 protein
nickel sulfate affects the phosphorylation of MTF1 protein

PMID:19131640 PMID:24962574

NCBI chr 4:124,696,342...124,743,593
Ensembl chr 4:124,695,897...124,743,593

G

metal response element binding transcription factor 2

affects expression

nickel sulfate affects the expression of MTF2 mRNA

NCBI chr 5:108,213,518...108,257,085
Ensembl chr 5:108,213,540...108,256,870

G

myotubularin related protein 1

decreases expression

nickel sulfate results in decreased expression of MTMR1 mRNA

NCBI chr X:70,408,332...70,462,802
Ensembl chr X:70,408,366...70,462,802

G

MTSS I-BAR domain containing 1

increases expression

nickel sulfate results in increased expression of MTSS1 mRNA

PMID:16780908 PMID:17382205

NCBI chr15:58,813,083...58,955,805
Ensembl chr15:58,813,083...58,953,854

G

mitochondrial tumor suppressor 1

increases expression

nickel sulfate results in increased expression of MTUS1 mRNA

NCBI chr 8:41,443,949...41,587,318
Ensembl chr 8:41,443,951...41,586,763

G

mucin 1, transmembrane

decreases expression

nickel sulfate results in decreased expression of MUC1 mRNA

NCBI chr 3:89,136,363...89,140,688
Ensembl chr 3:89,136,364...89,140,688

G

mevalonate (diphospho) decarboxylase

increases expression

nickel sulfate results in increased expression of MVD mRNA

PMID:18651567 PMID:22714537

NCBI chr 8:123,160,335...123,170,161
Ensembl chr 8:123,160,340...123,170,161

G

MX dynamin-like GTPase 1

increases expression

nickel sulfate results in increased expression of MX1 mRNA

NCBI chr16:97,248,235...97,264,106
Ensembl chr16:97,248,235...97,264,107

G

myeloid-associated differentiation marker

decreases expression

nickel sulfate results in decreased expression of MYADM mRNA

NCBI chr 7:3,337,563...3,347,871
Ensembl chr 7:3,337,605...3,348,958

G

myelocytomatosis oncogene

decreases expression
multiple interactions
increases degradation
increases ubiquitination
increases phosphorylation
increases expression

nickel sulfate results in decreased expression of MYC mRNA; nickel sulfate results in decreased expression of MYC protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [nickel sulfate results in increased expression of MYC protein]; [HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in increased degradation of MYC protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [nickel sulfate results in increased degradation of MYC protein]; FBXW7 mRNA affects the reaction [nickel sulfate results in increased degradation of MYC protein]; FBXW7 protein affects the reaction [nickel sulfate results in increased degradation of MYC protein]; U 0126 inhibits the reaction [nickel sulfate results in increased expression of MYC protein]; USP28 protein inhibits the reaction [nickel sulfate results in increased degradation of MYC protein]
nickel sulfate results in increased ubiquitination of MYC protein
nickel sulfate results in increased phosphorylation of MYC protein
nickel sulfate results in increased expression of MYC mRNA
nickel sulfate results in increased expression of MYC mRNA; nickel sulfate results in increased expression of MYC protein

PMID:16166746 PMID:17374397 PMID:19135467 PMID:20046830 PMID:23568779

NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223

G

v-myc avian myelocytomatosis viral oncogene lung carcinoma derived

decreases expression

nickel sulfate results in decreased expression of MYCL mRNA

NCBI chr 4:122,889,414...122,896,278
Ensembl chr 4:122,889,445...122,896,278

G

myosin, heavy polypeptide 1, skeletal muscle, adult

increases expression

nickel sulfate results in increased expression of MYH1 mRNA

NCBI chr11:67,090,922...67,115,401
Ensembl chr11:67,090,878...67,115,401

G

myosin, heavy polypeptide 10, non-muscle

decreases expression

nickel sulfate results in decreased expression of MYH10 mRNA

NCBI chr11:68,581,228...68,707,451
Ensembl chr11:68,582,385...68,707,458

G

myosin, light polypeptide 1

increases expression

nickel sulfate results in increased expression of MYL1 mRNA

NCBI chr 1:66,963,454...66,987,091
Ensembl chr 1:66,963,454...66,984,563

G

myosin, light polypeptide 2, regulatory, cardiac, slow

increases expression

nickel sulfate results in increased expression of MYL2 mRNA

NCBI chr 5:122,230,787...122,251,536
Ensembl chr 5:122,239,014...122,251,535

G

myosin regulatory light chain interacting protein

increases expression

nickel sulfate results in increased expression of MYLIP mRNA

NCBI chr13:45,543,197...45,565,498
Ensembl chr13:45,543,218...45,565,498

G

myosin light chain, phosphorylatable, fast skeletal muscle

increases expression

nickel sulfate results in increased expression of MYLPF mRNA

NCBI chr 7:126,808,071...126,813,459
Ensembl chr 7:126,808,062...126,813,470

G

myosin X

increases expression

nickel sulfate results in increased expression of MYO10 mRNA

NCBI chr15:25,622,636...25,813,759
Ensembl chr15:25,622,611...25,813,759

G

myosin XVIIIA

increases expression

nickel sulfate results in increased expression of MYO18A mRNA

NCBI chr11:77,654,066...77,756,806
Ensembl chr11:77,654,072...77,756,806

G

myosin IE

increases expression

nickel sulfate results in increased expression of MYO1E mRNA

NCBI chr 9:70,114,632...70,307,349
Ensembl chr 9:70,114,632...70,307,048

G

myosin VC

decreases expression

nickel sulfate results in decreased expression of MYO5C mRNA

NCBI chr 9:75,139,252...75,212,733
Ensembl chr 9:75,139,302...75,212,733

G

myocardin

increases expression

nickel sulfate results in increased expression of MYOCD mRNA

NCBI chr11:65,064,434...65,160,821
Ensembl chr11:65,067,387...65,160,815

G

myoferlin

increases expression

nickel sulfate results in increased expression of MYOF mRNA

NCBI chr19:37,887,484...38,032,025
Ensembl chr19:37,887,484...38,032,025

G

myopalladin

increases expression

nickel sulfate results in increased expression of MYPN mRNA

NCBI chr10:62,951,574...63,039,731
Ensembl chr10:62,951,574...63,039,731

G

N-acylethanolamine acid amidase

decreases expression

nickel sulfate results in decreased expression of NAAA mRNA

NCBI chr 5:92,405,519...92,426,040
Ensembl chr 5:92,405,518...92,426,029

G

nicotinamide phosphoribosyltransferase

increases expression

nickel sulfate results in increased expression of NAMPT mRNA

NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348

G

N-acetylneuraminic acid phosphatase

decreases expression

nickel sulfate results in decreased expression of NANP mRNA

NCBI chr 2:150,871,605...150,881,299
Ensembl chr 2:150,871,605...150,881,318

G

N-ethylmaleimide sensitive fusion protein attachment protein beta

decreases expression

nickel sulfate results in decreased expression of NAPB mRNA

NCBI chr 2:148,535,905...148,574,396
Ensembl chr 2:148,535,905...148,574,387

G

napsin A aspartic peptidase

decreases expression

nickel sulfate results in decreased expression of NAPSA mRNA

NCBI chr 7:44,221,869...44,236,270
Ensembl chr 7:44,221,804...44,236,286

G

neuron navigator 3

increases expression

nickel sulfate results in increased expression of NAV3 mRNA

PMID:17382205 PMID:22714537

NCBI chr10:109,517,121...110,292,148
Ensembl chr10:109,517,120...110,292,065

G

neutrophil cytosolic factor 2

decreases expression

nickel sulfate results in decreased expression of NCF2 mRNA

NCBI chr 1:152,675,904...152,712,743
Ensembl chr 1:152,675,945...152,712,742

G

nuclear receptor coactivator 4

decreases expression

nickel sulfate results in decreased expression of NCOA4 mRNA

NCBI chr14:31,881,884...31,901,210
Ensembl chr14:31,881,822...31,901,812

G

nuclear receptor coactivator 7

increases expression

nickel sulfate results in increased expression of NCOA7 mRNA

NCBI chr10:30,521,578...30,683,401
Ensembl chr10:30,504,995...30,679,322

G

N-myc downstream regulated gene 1

affects expression
increases expression
multiple interactions

nickel sulfate affects the expression of NDRG1 mRNA
nickel sulfate results in increased expression of NDRG1 mRNA; nickel sulfate results in increased expression of NDRG1 protein
Ascorbic Acid inhibits the reaction [nickel sulfate results in increased expression of NDRG1 protein]

PMID:12718980 PMID:16288478 PMID:17382205

NCBI chr15:66,801,167...66,841,490
Ensembl chr15:66,801,167...66,841,489

G

N-myc downstream regulated gene 2

increases expression

nickel sulfate results in increased expression of NDRG2 mRNA

NCBI chr14:52,142,738...52,151,463
Ensembl chr14:52,142,728...52,151,615

G

NADH:ubiquinone oxidoreductase complex assembly factor 5

decreases expression

nickel sulfate results in decreased expression of NDUFAF5 mRNA

NCBI chr 2:140,012,504...140,047,172
Ensembl chr 2:140,012,569...140,045,609

G

neural precursor cell expressed, developmentally down-regulated gene 9

increases expression

nickel sulfate results in increased expression of NEDD9 mRNA

NCBI chr13:41,463,392...41,640,836
Ensembl chr13:41,463,057...41,640,838

G

neuronal growth regulator 1

decreases expression

nickel sulfate results in decreased expression of NEGR1 mRNA

NCBI chr 3:156,266,082...157,022,101
Ensembl chr 3:156,267,431...157,022,082

G

neuroepithelial cell transforming gene 1

increases expression

nickel sulfate results in increased expression of NET1 mRNA

NCBI chr13:3,932,018...3,968,220
Ensembl chr13:3,932,018...3,968,220

G

neuraminidase 1

increases expression

nickel sulfate results in increased expression of NEU1 mRNA

NCBI chr17:35,150,229...35,156,273
Ensembl chr17:35,150,229...35,154,929

G

nexilin

decreases expression

nickel sulfate results in decreased expression of NEXN mRNA

NCBI chr 3:151,942,619...151,972,000
Ensembl chr 3:151,942,619...151,971,987

G

neurofascin

decreases expression

nickel sulfate results in decreased expression of NFASC mRNA

NCBI chr 1:132,492,428...132,669,567
Ensembl chr 1:132,492,428...132,669,535

G

nuclear factor, erythroid derived 2, like 2

increases expression
increases methylation
multiple interactions

nickel sulfate results in increased expression of NFE2L2 protein
nickel sulfate results in increased methylation of NFE2L2 promoter
Quercetin inhibits the reaction [nickel sulfate results in increased methylation of NFE2L2 promoter]

PMID:19033392 PMID:25957741

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor I/B

decreases expression

nickel sulfate results in decreased expression of NFIB mRNA

NCBI chr 4:82,208,410...82,424,988
Ensembl chr 4:82,208,410...82,623,987

G

nuclear factor, interleukin 3, regulated

increases expression

nickel sulfate results in increased expression of NFIL3 mRNA

PMID:16780908 PMID:18651567

NCBI chr13:53,121,245...53,136,914
Ensembl chr13:53,121,245...53,135,109

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

increases expression
affects expression

nickel sulfate results in increased expression of NFKB1 mRNA
nickel sulfate affects the expression of NFKB1 mRNA

PMID:16780908 PMID:20385217

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

increases degradation
multiple interactions
increases expression

nickel sulfate results in increased degradation of NFKBIA protein
[nickel sulfate results in increased degradation of NFKBIA protein] which results in increased activity of RELA protein; BAY 11-7085 inhibits the reaction [nickel sulfate results in increased degradation of NFKBIA protein]
nickel sulfate results in increased expression of NFKBIA mRNA

PMID:16780908 PMID:17636246 PMID:19101624 PMID:22714537

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nidogen 1

decreases expression

nickel sulfate results in decreased expression of NID1 mRNA

NCBI chr13:13,612,252...13,686,849
Ensembl chr13:13,612,136...13,686,854

G

ninjurin 1

increases expression

nickel sulfate results in increased expression of NINJ1 mRNA

PMID:16314067 PMID:16780908 PMID:17374397 PMID:22714537

NCBI chr13:49,341,005...49,349,727
Ensembl chr13:49,340,961...49,349,720

G

ninein-like

decreases expression

nickel sulfate results in decreased expression of NINL mRNA

NCBI chr 2:150,776,439...150,851,330
Ensembl chr 2:150,776,439...150,881,302

G

NLR family, pyrin domain containing 10

decreases expression

nickel sulfate results in decreased expression of NLRP10 mRNA

NCBI chr 7:108,521,060...108,529,365
Ensembl chr 7:108,521,059...108,529,385

G

N-myristoyltransferase 2

decreases expression

nickel sulfate results in decreased expression of NMT2 mRNA

NCBI chr 2:3,285,249...3,329,914
Ensembl chr 2:3,285,249...3,329,914

G

neuromedin U

decreases expression

nickel sulfate results in decreased expression of NMU mRNA

NCBI chr 5:76,481,342...76,511,624
Ensembl chr 5:76,481,342...76,511,635

G

NOC3 like DNA replication regulator

decreases expression

nickel sulfate results in decreased expression of NOC3L mRNA

NCBI chr19:38,776,565...38,808,754
Ensembl chr19:38,776,572...38,807,681

G

nucleolar protein 4-like

increases expression

nickel sulfate results in increased expression of NOL4L mRNA

NCBI chr 2:153,249,381...153,371,869
Ensembl chr 2:153,249,382...153,371,891

G

NOP56 ribonucleoprotein

decreases expression

nickel sulfate results in decreased expression of NOP56 mRNA

NCBI chr 2:130,112,904...130,121,233
Ensembl chr 2:130,116,350...130,121,233

G

nitric oxide synthase 2, inducible

increases expression
multiple interactions
increases activity

nickel sulfate results in increased expression of NOS2 mRNA
Ascorbic Acid inhibits the reaction [nickel sulfate results in increased activity of NOS2 protein]
nickel sulfate results in increased expression of NOS2 protein
nickel sulfate promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; nickel sulfate promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [nickel sulfate results in increased expression of NOS2 protein]

PMID:11114790 PMID:23415871 PMID:23463385 PMID:25957741

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

NOVA alternative splicing regulator 1

decreases expression

nickel sulfate results in decreased expression of NOVA1 mRNA

NCBI chr12:46,744,678...46,866,143
Ensembl chr12:46,741,300...46,865,712

G

neuronal PAS domain protein 2

increases expression

nickel sulfate results in increased expression of NPAS2 mRNA

PMID:17382205 PMID:22714537

NCBI chr 1:39,233,013...39,402,321
Ensembl chr 1:39,232,812...39,402,317

G

N-acetylneuraminate pyruvate lyase

decreases expression

nickel sulfate results in decreased expression of NPL mRNA

NCBI chr 1:153,378,762...153,425,460
Ensembl chr 1:153,378,761...153,425,791

G

natriuretic peptide type B

decreases expression

nickel sulfate results in decreased expression of NPPB mRNA

NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662

G

natriuretic peptide receptor 2

increases expression

nickel sulfate results in increased expression of NPR2 mRNA

NCBI chr 4:43,629,015...43,651,437
Ensembl chr 4:43,631,935...43,651,244

G

NAD(P)H dehydrogenase, quinone 1

increases expression

nickel sulfate results in increased expression of NQO1 mRNA

PMID:16314067 PMID:19033392 PMID:20566472 PMID:22714537

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

N-ribosyldihydronicotinamide quinone reductase 2

increases expression

nickel sulfate results in increased expression of NQO2 mRNA

NCBI chr13:34,148,642...34,172,448
Ensembl chr13:34,148,670...34,172,426

G

nuclear receptor subfamily 1, group H, member 3

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of NR1H3 mRNA

NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179

G

nuclear receptor subfamily 2, group F, member 6

increases expression

nickel sulfate results in increased expression of NR2F6 mRNA

NCBI chr 8:71,826,762...71,834,593
Ensembl chr 8:71,826,767...71,834,604

G

nuclear receptor subfamily 3, group C, member 1

increases expression

nickel sulfate results in increased expression of NR3C1 mRNA

NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474

G

nuclear receptor subfamily 4, group A, member 1

increases expression

nickel sulfate results in increased expression of NR4A1 mRNA

NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676

G

nuclear receptor subfamily 4, group A, member 2

increases expression

nickel sulfate results in increased expression of NR4A2 mRNA

NCBI chr 2:56,996,845...57,014,152
Ensembl chr 2:56,996,842...57,014,015

G

neuronal regeneration related protein

decreases expression

nickel sulfate results in decreased expression of NREP mRNA

PMID:16780908 PMID:17374397 PMID:22714537

NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082

G

neuregulin 1

decreases expression

nickel sulfate results in decreased expression of NRG1 mRNA

NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825

G

neuropilin 2

increases expression
decreases expression

nickel sulfate results in increased expression of NRP2 mRNA
nickel sulfate results in decreased expression of NRP2 mRNA

PMID:16780908 PMID:18832182

NCBI chr 1:62,742,476...62,857,851
Ensembl chr 1:62,742,444...62,857,854

G

neurensin 2

decreases expression

nickel sulfate results in decreased expression of NRSN2 mRNA

NCBI chr 2:152,210,675...152,218,560
Ensembl chr 2:152,210,675...152,218,558

G

NSFL1 (p97) cofactor (p47)

decreases expression

nickel sulfate results in decreased expression of NSFL1C mRNA

NCBI chr 2:151,336,102...151,353,230
Ensembl chr 2:151,336,102...151,353,334

G

5'-nucleotidase, cytosolic III

decreases expression

nickel sulfate results in decreased expression of NT5C3A mRNA

NCBI chr 6:56,859,385...56,900,993
Ensembl chr 6:56,859,385...56,900,917

G

N-terminal glutamine amidase 1

increases expression

nickel sulfate results in increased expression of NTAQ1 mRNA

NCBI chr15:58,004,730...58,022,050
Ensembl chr15:58,004,773...58,022,061

G

negative regulator of ubiquitin-like proteins 1

increases expression

nickel sulfate results in increased expression of NUB1 mRNA

NCBI chr 5:24,890,813...24,915,376
Ensembl chr 5:24,890,530...24,915,376

G

nucleobindin 1

decreases expression

nickel sulfate results in decreased expression of NUCB1 mRNA

NCBI chr 7:45,142,300...45,159,813
Ensembl chr 7:45,139,882...45,159,830

G

nudix hydrolase 14

increases expression

nickel sulfate results in increased expression of NUDT14 mRNA

NCBI chr12:112,897,911...112,905,762
Ensembl chr12:112,897,911...112,905,744

G

nudix hydrolase 7

increases expression

nickel sulfate results in increased expression of NUDT7 mRNA

NCBI chr 8:114,860,314...114,881,471
Ensembl chr 8:114,860,297...114,881,479

G

nucleoporin 210

decreases expression

nickel sulfate results in decreased expression of NUP210 mRNA

NCBI chr 6:90,990,049...91,095,920
Ensembl chr 6:90,990,050...91,093,811

G

nucleoporin 214

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of NUP214 mRNA

NCBI chr 2:31,864,446...31,943,204
Ensembl chr 2:31,864,448...31,943,987

G

nucleoporin 88

increases expression

nickel sulfate results in increased expression of NUP88 mRNA

PMID:16780908 PMID:17374397

NCBI chr11:70,833,884...70,860,799
Ensembl chr11:70,833,884...70,860,799

G

nucleoporin 98

increases expression

nickel sulfate results in increased expression of NUP98 mRNA

NCBI chr 7:101,768,607...101,859,359
Ensembl chr 7:101,768,605...101,859,383

G

2'-5' oligoadenylate synthetase 3

increases expression

nickel sulfate results in increased expression of OAS3 mRNA

NCBI chr 5:120,891,163...120,915,755
Ensembl chr 5:120,891,163...120,915,726

G

2'-5' oligoadenylate synthetase-like 1

increases expression

nickel sulfate results in increased expression of OASL mRNA

NCBI chr 5:115,061,236...115,075,970
Ensembl chr 5:115,061,299...115,075,974

G

ornithine decarboxylase, structural 1

increases expression

nickel sulfate results in increased expression of ODC1 mRNA

NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506

G

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

increases expression

nickel sulfate results in increased expression of OGDH mRNA

NCBI chr11:6,241,597...6,309,094
Ensembl chr11:6,241,633...6,306,642

G

olfactomedin-like 2B

increases expression

nickel sulfate results in increased expression of OLFML2B mRNA

NCBI chr 1:170,472,101...170,510,356
Ensembl chr 1:170,472,101...170,510,358

G

olfactory receptor family 2 subfamily A member 2

decreases expression

nickel sulfate results in decreased expression of OR2A9P mRNA

NCBI chr 6:43,193,849...43,194,814
Ensembl chr 6:43,189,955...43,195,047

G

oxysterol binding protein-like 5

increases expression

nickel sulfate results in increased expression of OSBPL5 mRNA

NCBI chr 7:143,242,499...143,310,745
Ensembl chr 7:143,242,499...143,310,722

G

oncostatin M receptor

increases expression

nickel sulfate results in increased expression of OSMR mRNA

NCBI chr15:6,843,049...6,904,434
Ensembl chr15:6,843,058...6,904,450

G

osteoclast stimulating factor 1

increases expression

nickel sulfate results in increased expression of OSTF1 mRNA

NCBI chr19:18,557,728...18,609,177
Ensembl chr19:18,493,501...18,609,187

G

OTU domain containing 1

increases expression

nickel sulfate results in increased expression of OTUD1 mRNA

NCBI chr 2:19,662,542...19,666,090
Ensembl chr 2:19,662,563...19,665,394

G

3-oxoacid CoA transferase 1

decreases expression

nickel sulfate results in decreased expression of OXCT1 mRNA

NCBI chr15:4,055,910...4,184,826
Ensembl chr15:4,055,865...4,184,826

G

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide

increases expression

nickel sulfate results in increased expression of P4HA2 mRNA

NCBI chr11:53,991,750...54,022,494
Ensembl chr11:53,990,921...54,022,491

G

PABIR family member 3

increases expression

nickel sulfate results in increased expression of PABIR3 mRNA

NCBI chr X:52,362,296...52,420,063
Ensembl chr X:52,362,301...52,420,062

G

palladin, cytoskeletal associated protein

decreases expression

nickel sulfate results in decreased expression of PALLD mRNA

NCBI chr 8:61,964,465...62,355,741
Ensembl chr 8:61,964,467...62,355,724

G

peptidylglycine alpha-amidating monooxygenase

decreases expression

nickel sulfate results in decreased expression of PAM mRNA

NCBI chr 1:97,748,816...98,023,578
Ensembl chr 1:97,722,839...98,023,371

G

peptidase domain containing associated with muscle regeneration 1

decreases expression

nickel sulfate results in decreased expression of PAMR1 mRNA

NCBI chr 2:102,380,325...102,473,386
Ensembl chr 2:102,380,357...102,473,386

G

progestin and adipoQ receptor family member V

decreases expression

nickel sulfate results in decreased expression of PAQR5 mRNA

NCBI chr 9:61,861,020...61,934,085
Ensembl chr 9:61,860,763...61,934,138

G

poly (ADP-ribose) polymerase family, member 1

increases cleavage
multiple interactions

nickel sulfate results in increased cleavage of PARP1 protein
3-aminobenzamide inhibits the reaction [PARP1 protein results in increased susceptibility to [Potassium Dichromate co-treated with nickel sulfate]]; nickel sulfate inhibits the reaction [Potassium Dichromate results in increased cleavage of and results in increased activity of PARP1 protein]; nickel sulfate results in increased cleavage of and results in increased activity of PARP1 protein; PARP1 protein results in increased susceptibility to [Potassium Dichromate co-treated with nickel sulfate]; Potassium Dichromate inhibits the reaction [nickel sulfate results in increased cleavage of and results in increased activity of PARP1 protein]

PMID:19135467 PMID:20493934

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

pre B cell leukemia homeobox 1

increases expression

nickel sulfate results in increased expression of PBX1 mRNA

NCBI chr 1:167,946,933...168,259,898
Ensembl chr 1:167,946,933...168,259,839

G

protocadherin beta 19

increases expression

nickel sulfate results in increased expression of PCDHB12 mRNA

NCBI chr18:37,630,049...37,637,181
Ensembl chr18:37,630,044...37,637,181

G

polycomb group ring finger 5

decreases expression

nickel sulfate results in decreased expression of PCGF5 mRNA

NCBI chr19:36,325,729...36,438,370
Ensembl chr19:36,325,709...36,438,370

G

proliferating cell nuclear antigen

decreases expression

nickel sulfate results in decreased expression of PCNA mRNA

NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234

G

procollagen C-endopeptidase enhancer 2

decreases expression

nickel sulfate results in decreased expression of PCOLCE2 mRNA

NCBI chr 9:95,519,681...95,577,604
Ensembl chr 9:95,519,654...95,580,149

G

phosphate cytidylyltransferase 2, ethanolamine

increases expression

nickel sulfate results in increased expression of PCYT2 mRNA

NCBI chr11:120,500,888...120,508,784
Ensembl chr11:120,500,913...120,508,762

G

phosphodiesterase 10A

increases expression

nickel sulfate results in increased expression of PDE10A mRNA

NCBI chr17:8,742,719...9,205,480
Ensembl chr17:8,744,204...9,205,480

G

phosphodiesterase 3A, cGMP inhibited

increases expression

nickel sulfate results in increased expression of PDE3A mRNA

NCBI chr 6:141,194,995...141,452,588
Ensembl chr 6:141,194,995...141,453,174

G

phosphodiesterase 4B, cAMP specific

increases expression

nickel sulfate results in increased expression of PDE4B mRNA

PMID:16780908 PMID:17374397

NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456

G

phosphodiesterase 4D, cAMP specific

increases expression

nickel sulfate results in increased expression of PDE4D mRNA

NCBI chr13:108,790,711...110,092,503
Ensembl chr13:108,586,482...110,089,995

G

phosphodiesterase 4D interacting protein (myomegalin)

decreases expression

nickel sulfate results in decreased expression of PDE4DIP mRNA

NCBI chr 3:97,597,144...97,796,023
Ensembl chr 3:97,597,140...97,796,023

G

phosphodiesterase 9A

increases expression

nickel sulfate results in increased expression of PDE9A mRNA

NCBI chr17:31,605,079...31,695,284
Ensembl chr17:31,605,184...31,695,284

G

platelet derived growth factor, alpha

increases expression

nickel sulfate results in increased expression of PDGFA mRNA

PMID:16780908 PMID:22714537

NCBI chr 5:138,961,761...138,986,336
Ensembl chr 5:138,961,769...138,983,125

G

PDZ and LIM domain 3

increases expression

nickel sulfate results in increased expression of PDLIM3 mRNA

NCBI chr 8:46,338,524...46,372,672
Ensembl chr 8:46,338,498...46,372,585

G

podoplanin

decreases expression

nickel sulfate results in decreased expression of PDPN mRNA

NCBI chr 4:142,993,979...143,026,134
Ensembl chr 4:142,994,001...143,026,134

G

PDZ domain containing 2

decreases expression

nickel sulfate results in decreased expression of PDZD2 mRNA

NCBI chr15:12,359,797...12,740,052
Ensembl chr15:12,359,797...12,740,010

G

PDZ domain containing 1

decreases expression

nickel sulfate results in decreased expression of PDZK1 mRNA

NCBI chr 3:96,736,772...96,778,242
Ensembl chr 3:96,736,600...96,778,242

G

paternally expressed 10

increases expression

nickel sulfate results in increased expression of PEG10 mRNA

NCBI chr 6:4,747,306...4,760,517
Ensembl chr 6:4,747,306...4,760,517

G

pellino 1

decreases expression

nickel sulfate results in decreased expression of PELI1 mRNA

NCBI chr11:21,041,283...21,100,327
Ensembl chr11:21,041,291...21,100,323

G

pelota mRNA surveillance and ribosome rescue factor

decreases expression

nickel sulfate results in decreased expression of PELO mRNA

NCBI chr13:115,224,891...115,226,694
Ensembl chr13:115,224,891...115,226,722

G

PERP, TP53 apoptosis effector

increases expression

nickel sulfate results in increased expression of PERP mRNA

NCBI chr10:18,720,819...18,732,821
Ensembl chr10:18,720,768...18,732,821

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

increases expression

nickel sulfate results in increased expression of PFKFB3 mRNA

NCBI chr 2:11,476,241...11,558,882
Ensembl chr 2:11,476,244...11,558,888

G

phosphogluconate dehydrogenase

increases expression

nickel sulfate results in increased expression of PGD mRNA

PMID:16314067 PMID:20566472

NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228

G

placental growth factor

multiple interactions
increases expression

[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of PGF mRNA
nickel sulfate results in increased expression of PGF mRNA

PMID:18651567 PMID:18832182 PMID:22714537

NCBI chr12:85,213,413...85,224,087
Ensembl chr12:85,213,409...85,224,564

G

phosphoglycerate kinase 1

increases expression
affects expression

nickel sulfate results in increased expression of PGK1 mRNA
nickel sulfate affects the expression of PGK1 mRNA

PMID:16100012 PMID:17382205 PMID:18202158

NCBI chr X:105,230,706...105,247,305
Ensembl chr X:105,230,706...105,247,305

G

peptidoglycan recognition protein 1

increases expression

nickel sulfate results in increased expression of PGLYRP1 mRNA

NCBI chr 7:18,618,615...18,624,363
Ensembl chr 7:18,605,256...18,624,384

G

phosphoglucomutase 1

decreases expression

nickel sulfate results in decreased expression of PGM1 mRNA

NCBI chr 4:99,786,648...99,844,491
Ensembl chr 4:99,786,611...99,844,491

G

PHD finger protein 1

increases expression
multiple interactions

nickel sulfate results in increased expression of PHF1 mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of PHF1 mRNA

PMID:22714537 PMID:31734292

NCBI chr17:27,152,101...27,156,882
Ensembl chr17:27,152,026...27,156,882

G

PHD finger protein 12

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of PHF12 mRNA

NCBI chr11:77,873,515...77,921,365
Ensembl chr11:77,873,580...77,921,365

G

phosphorylase kinase alpha 1

decreases expression
increases expression

nickel sulfate results in decreased expression of PHKA1 mRNA
nickel sulfate results in increased expression of PHKA1 mRNA

PMID:16166746 PMID:22714537

NCBI chr X:101,557,581...101,687,907
Ensembl chr X:101,557,581...101,687,852

G

pleckstrin homology like domain, family A, member 1

increases expression

nickel sulfate results in increased expression of PHLDA1 mRNA

PMID:16780908 PMID:17374397

NCBI chr10:111,342,147...111,344,510
Ensembl chr10:111,342,147...111,344,506

G

phosphatidylinositol binding clathrin assembly protein

increases expression

nickel sulfate results in increased expression of PICALM mRNA

PMID:16780908 PMID:17374397

NCBI chr 7:89,778,711...89,858,655
Ensembl chr 7:89,779,421...89,862,673

G

piezo-type mechanosensitive ion channel component 2

increases expression

nickel sulfate results in increased expression of PIEZO2 mRNA

NCBI chr18:63,143,284...63,520,787
Ensembl chr18:63,143,284...63,520,254

G

phosphatidylinositol glycan anchor biosynthesis, class M

decreases expression

nickel sulfate results in decreased expression of PIGM mRNA

NCBI chr 1:172,204,098...172,211,666
Ensembl chr 1:172,204,113...172,211,666

G

paired immunoglobin-like type 2 receptor alpha

increases expression

nickel sulfate results in increased expression of PILRA mRNA

NCBI chr 5:137,820,214...137,834,540
Ensembl chr 5:137,820,214...137,834,543

G

proviral integration site 1

increases expression

nickel sulfate results in increased expression of PIM1 mRNA

PMID:18651567 PMID:22714537

NCBI chr17:29,709,759...29,715,085
Ensembl chr17:29,709,727...29,715,086

G

peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1

increases expression

nickel sulfate results in increased expression of PIN1 mRNA

NCBI chr 9:20,563,335...20,575,008
Ensembl chr 9:20,563,391...20,577,880

G

pirin

increases expression

nickel sulfate results in increased expression of PIR mRNA

PMID:16314067 PMID:22714537

NCBI chr X:163,052,427...163,156,009
Ensembl chr X:163,052,367...163,156,007

G

plakophilin 3

increases expression

nickel sulfate results in increased expression of PKP3 mRNA

NCBI chr 7:140,658,202...140,670,424
Ensembl chr 7:140,658,131...140,670,423

G

phospholipase A and acyltransferase 3

increases expression

nickel sulfate results in increased expression of PLAAT3 mRNA

PMID:16780908 PMID:22714537

NCBI chr19:7,534,824...7,565,914
Ensembl chr19:7,534,824...7,565,910

G

pleiomorphic adenoma gene-like 1

decreases expression

nickel sulfate results in decreased expression of PLAGL1 mRNA

PMID:16166746 PMID:22714537

NCBI chr10:12,966,576...13,007,438
Ensembl chr10:12,936,248...13,007,438

G

plasminogen activator, tissue

increases expression

nickel sulfate results in increased expression of PLAT mRNA

PMID:16100012 PMID:16780908 PMID:17374397

NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860

G

plasminogen activator, urokinase

multiple interactions
decreases expression

[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in decreased expression of PLAU mRNA
nickel sulfate results in decreased expression of PLAU mRNA

NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453

G

plasminogen activator, urokinase receptor

decreases expression

nickel sulfate results in decreased expression of PLAUR mRNA

PMID:16780908 PMID:22714537

NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393

G

phospholipase C, epsilon 1

decreases expression

nickel sulfate results in decreased expression of PLCE1 mRNA

NCBI chr19:38,469,438...38,773,549
Ensembl chr19:38,469,557...38,773,474

G

phospholipase C, gamma 2

increases expression

nickel sulfate results in increased expression of PLCG2 mRNA

NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881

G

phosphatidylinositol-specific phospholipase C, X domain containing 1

increases expression

nickel sulfate results in increased expression of PLCXD1 mRNA

NCBI chr 5:110,247,661...110,253,819
Ensembl chr 5:110,247,835...110,253,819

G

phospholipase D family member 3

increases expression

nickel sulfate results in increased expression of PLD3 mRNA

NCBI chr 7:27,231,090...27,252,511
Ensembl chr 7:27,231,425...27,252,643

G

plectin

increases expression

nickel sulfate results in increased expression of PLEC mRNA

NCBI chr15:76,055,174...76,115,578
Ensembl chr15:76,055,174...76,116,774

G

pleckstrin

increases expression

nickel sulfate results in increased expression of PLEK mRNA

NCBI chr11:16,921,206...16,958,718
Ensembl chr11:16,921,206...17,002,381

G

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

decreases expression

nickel sulfate results in decreased expression of PLEKHA1 mRNA

NCBI chr 7:130,462,281...130,515,224
Ensembl chr 7:130,467,486...130,515,042

G

pleckstrin homology domain containing, family A member 7

decreases expression

nickel sulfate results in decreased expression of PLEKHA7 mRNA

NCBI chr 7:115,722,722...115,907,617
Ensembl chr 7:115,722,720...115,907,611

G

pleckstrin homology domain containing, family H (with MyTH4 domain) member 2

increases expression

nickel sulfate results in increased expression of PLEKHH2 mRNA

NCBI chr17:84,819,303...84,929,571
Ensembl chr17:84,819,323...84,929,566

G

perilipin 2

increases expression

nickel sulfate results in increased expression of PLIN2 mRNA

PMID:16314067 PMID:18651567

NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297

G

polo like kinase 2

decreases expression

nickel sulfate results in decreased expression of PLK2 mRNA

NCBI chr13:110,531,578...110,537,378
Ensembl chr13:110,531,580...110,537,378

G

phospholipid phosphatase 4

decreases expression

nickel sulfate results in decreased expression of PLPP4 mRNA

NCBI chr 7:128,858,114...128,993,138
Ensembl chr 7:128,858,755...128,993,136

G

plastin 3 (T-isoform)

decreases expression

nickel sulfate results in decreased expression of PLS3 mRNA

NCBI chr X:74,829,259...74,918,788
Ensembl chr X:74,829,260...74,918,788

G

phospholipid scramblase 1

increases expression

nickel sulfate results in increased expression of PLSCR1 mRNA

NCBI chr 9:92,132,265...92,154,034
Ensembl chr 9:92,131,803...92,154,331

G

phospholipid scramblase 4

increases expression

nickel sulfate results in increased expression of PLSCR4 mRNA

NCBI chr 9:92,339,431...92,374,509
Ensembl chr 9:92,339,426...92,374,509

G

phospholipid transfer protein

decreases expression

nickel sulfate results in decreased expression of PLTP mRNA

NCBI chr 2:164,681,441...164,699,564
Ensembl chr 2:164,681,438...164,699,631

G

plexin A2

decreases expression

nickel sulfate results in decreased expression of PLXNA2 mRNA

NCBI chr 1:194,302,020...194,499,177
Ensembl chr 1:194,300,526...194,499,177

G

plexin A3

decreases expression

nickel sulfate results in decreased expression of PLXNA3 mRNA

NCBI chr X:73,372,644...73,388,295
Ensembl chr X:73,372,672...73,388,295

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

nickel sulfate results in increased expression of PMAIP1 mRNA

PMID:16314067 PMID:16780908

NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636

G

paroxysmal nonkinesiogenic dyskinesia

increases expression

nickel sulfate results in increased expression of PNKD mRNA

NCBI chr 1:74,323,757...74,392,851
Ensembl chr 1:74,324,089...74,392,853

G

protein O-glucosyltransferase 2

decreases expression

nickel sulfate results in decreased expression of POGLUT2 mRNA

NCBI chr 1:44,143,060...44,158,844
Ensembl chr 1:44,145,706...44,157,968

G

RNA polymerase I subunit H, antisense

increases expression

nickel sulfate results in increased expression of POLR1HASP mRNA

NCBI chr17:37,269,483...37,276,722
Ensembl chr17:37,269,484...37,276,517

G

polymerase (RNA) II (DNA directed) polypeptide A

increases expression

nickel sulfate results in increased expression of POLR2A mRNA

NCBI chr11:69,624,823...69,649,459
Ensembl chr11:69,624,823...69,649,463

G

polymerase (RNA) III (DNA directed) polypeptide F

decreases expression

nickel sulfate results in decreased expression of POLR3F mRNA

NCBI chr 2:144,369,665...144,383,699
Ensembl chr 2:144,369,638...144,383,915

G

polymerase (RNA) III (DNA directed) polypeptide G

increases expression

nickel sulfate results in increased expression of POLR3G mRNA

NCBI chr13:81,821,956...81,859,132
Ensembl chr13:81,821,962...81,859,132

G

porcupine O-acyltransferase

increases expression

nickel sulfate results in increased expression of PORCN mRNA

NCBI chr X:8,060,085...8,072,794
Ensembl chr X:8,060,087...8,072,764

G

periostin, osteoblast specific factor

increases expression

nickel sulfate results in increased expression of POSTN mRNA

NCBI chr 3:54,266,688...54,298,462
Ensembl chr 3:54,268,530...54,298,458

G

peroxisome proliferator activated receptor gamma

increases expression

nickel sulfate results in increased expression of PPARG mRNA

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

multiple interactions
decreases expression

[nickel sulfate co-treated with Particulate Matter] results in decreased expression of PPARGC1A mRNA
nickel sulfate results in decreased expression of PPARGC1A mRNA

NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068

G

peptidylprolyl isomerase A

affects expression

nickel sulfate affects the expression of PPIA mRNA

NCBI chr11:6,365,867...6,369,817
Ensembl chr11:6,365,443...6,369,817

G

peptidylprolyl isomerase D (cyclophilin D)

decreases expression

nickel sulfate results in decreased expression of PPID mRNA

NCBI chr 3:79,498,644...79,511,117
Ensembl chr 3:79,498,649...79,510,957

G

protein phosphatase 1H (PP2C domain containing)

increases expression

nickel sulfate results in increased expression of PPM1H mRNA

NCBI chr10:122,512,720...122,781,700
Ensembl chr10:122,514,667...122,781,700

G

protein phosphatase 1, regulatory subunit 15A

increases expression

nickel sulfate results in increased expression of PPP1R15A mRNA

NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692

G

protein phosphatase 2, regulatory subunit A, alpha

increases expression

nickel sulfate results in increased expression of PPP2R1A mRNA

NCBI chr17:21,165,716...21,186,167
Ensembl chr17:21,165,573...21,186,178

G

protein phosphatase 2, regulatory subunit A, beta

increases expression

nickel sulfate results in increased expression of PPP2R1B mRNA

NCBI chr 9:50,767,946...50,810,625
Ensembl chr 9:50,756,601...50,805,529

G

protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta

increases expression

nickel sulfate results in increased expression of PPP2R3B mRNA

NCBI chr 9:124,195,310...124,204,755
Ensembl chr 9:124,195,412...124,204,759

G

protein phosphatase 2, regulatory subunit B', beta

increases expression

nickel sulfate results in increased expression of PPP2R5B mRNA

NCBI chr19:6,277,795...6,286,294
Ensembl chr19:6,277,795...6,285,902

G

PR domain containing 1, with ZNF domain

increases expression

nickel sulfate results in increased expression of PRDM1 mRNA

NCBI chr10:44,313,170...44,404,579
Ensembl chr10:44,313,173...44,404,497

G

peroxiredoxin 3

decreases expression

nickel sulfate results in decreased expression of PRDX3 mRNA

NCBI chr19:60,852,504...60,862,976
Ensembl chr19:60,852,489...60,862,994

G

prickle planar cell polarity protein 1

decreases expression

nickel sulfate results in decreased expression of PRICKLE1 mRNA

NCBI chr15:93,396,992...93,494,147
Ensembl chr15:93,396,995...93,493,772

G

protein kinase, AMP-activated, beta 2 non-catalytic subunit

decreases expression

nickel sulfate results in decreased expression of PRKAB2 mRNA

NCBI chr 3:97,565,527...97,581,128
Ensembl chr 3:97,565,509...97,581,128

G

protein kinase, cAMP dependent regulatory, type II beta

increases expression

nickel sulfate results in increased expression of PRKAR2B mRNA

NCBI chr12:32,008,468...32,111,639
Ensembl chr12:32,008,475...32,111,295

G

protein kinase, X-linked

increases expression

nickel sulfate results in increased expression of PRKX mRNA

NCBI chr X:76,804,578...76,839,545
Ensembl chr X:76,805,017...76,839,884

G

prion protein

decreases expression

nickel sulfate results in decreased expression of PRNP mRNA

NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349

G

protein S (alpha)

decreases expression

nickel sulfate results in decreased expression of PROS1 mRNA

NCBI chr16:62,674,670...62,749,709
Ensembl chr16:62,674,670...62,749,709

G

phosphoribosyl pyrophosphate synthetase 2

increases expression

nickel sulfate results in increased expression of PRPS2 mRNA

NCBI chr X:166,129,316...166,165,887
Ensembl chr X:166,129,318...166,165,745

G

proline rich 16

increases expression

nickel sulfate results in increased expression of PRR16 mRNA

NCBI chr18:51,250,970...51,437,713
Ensembl chr18:51,250,805...51,553,116

G

proline rich Gla (G-carboxyglutamic acid) 1

decreases expression

nickel sulfate results in decreased expression of PRRG1 mRNA

NCBI chr X:77,493,216...77,627,539
Ensembl chr X:77,493,219...77,627,502

G

proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)

increases expression

nickel sulfate results in increased expression of PRRG4 mRNA

NCBI chr 2:104,657,374...104,680,216
Ensembl chr 2:104,661,086...104,680,221

G

serine protease 8 (prostasin)

increases expression

nickel sulfate results in increased expression of PRSS8 mRNA

NCBI chr 7:127,524,889...127,529,266
Ensembl chr 7:127,524,888...127,529,276

G

protogenin

increases expression

nickel sulfate results in increased expression of PRTG mRNA

NCBI chr 9:72,714,556...72,824,589
Ensembl chr 9:72,714,156...72,824,573

G

prune homolog 2

decreases expression

nickel sulfate results in decreased expression of PRUNE2 mRNA

NCBI chr19:16,933,033...17,201,322
Ensembl chr19:16,933,482...17,201,296

G

pleckstrin and Sec7 domain containing 3

decreases expression

nickel sulfate results in decreased expression of PSD3 mRNA

NCBI chr 8:68,141,728...68,664,740
Ensembl chr 8:68,141,734...68,664,679

G

proteasome subunit alpha 4

decreases expression

nickel sulfate results in decreased expression of PSMA4 mRNA

NCBI chr 9:54,858,074...54,865,316
Ensembl chr 9:54,858,074...54,865,314

G

proteasome subunit alpha 5

decreases expression

nickel sulfate results in decreased expression of PSMA5 mRNA

NCBI chr 3:108,164,242...108,187,268
Ensembl chr 3:108,164,242...108,187,290

G

proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)

increases expression

nickel sulfate results in increased expression of PSMB8 mRNA

NCBI chr17:34,417,169...34,420,428
Ensembl chr17:34,416,695...34,420,428

G

proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)

increases expression

nickel sulfate results in increased expression of PSMB9 mRNA

NCBI chr17:34,401,006...34,406,347
Ensembl chr17:34,400,961...34,406,738

G

proteasome (prosome, macropain) inhibitor subunit 1

decreases expression

nickel sulfate results in decreased expression of PSMF1 mRNA

NCBI chr 2:151,557,982...151,586,114
Ensembl chr 2:151,557,732...151,586,106

G

phosphatase and tensin homolog

increases expression

nickel sulfate results in increased expression of PTEN mRNA

NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560

G

prostaglandin E receptor 2 (subtype EP2)

increases expression
multiple interactions

nickel sulfate results in increased expression of PTGER2 mRNA
[[Dinoprostone results in increased activity of PTGER2 protein] which results in increased susceptibility to nickel sulfate] which results in increased secretion of CXCL8 protein; [Dinoprostone results in increased activity of PTGER2 protein] which results in increased susceptibility to nickel sulfate; nickel sulfate promotes the reaction [[Dinoprostone results in increased activity of PTGER2 protein] which results in increased chemical synthesis of Cyclic AMP]

PMID:16100012 PMID:23526216

NCBI chr14:45,225,568...45,241,277
Ensembl chr14:45,225,652...45,241,277

G

prostaglandin E receptor 3 (subtype EP3)

decreases expression

nickel sulfate results in decreased expression of PTGER3 mRNA

PMID:16780908 PMID:17374397

NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525

G

prostaglandin E receptor 4 (subtype EP4)

multiple interactions
increases expression

[[Dinoprostone results in increased activity of PTGER4 protein] which results in increased susceptibility to nickel sulfate] which results in increased secretion of CXCL8 protein; [Dinoprostone results in increased activity of PTGER4 protein] which results in increased susceptibility to nickel sulfate; nickel sulfate promotes the reaction [[Dinoprostone results in increased activity of PTGER4 protein] which results in increased chemical synthesis of Cyclic AMP]
nickel sulfate results in increased expression of PTGER4 mRNA

PMID:22714537 PMID:23526216

NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668

G

prostaglandin reductase 1

increases expression

nickel sulfate results in increased expression of PTGR1 mRNA

NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

nickel sulfate results in increased expression of PTGS2 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of PTGS2 protein]; [nickel sulfate co-treated with Dinoprostone] results in increased expression of PTGS2 protein; [nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of PTGS2 protein; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of PTGS2 mRNA]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of PTGS2 protein]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of PTGS2 mRNA]; PTGS2 mRNA affects the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of CXCL1 protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of CXCL5 protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of CXCL8 protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of PTGS2 protein]; U 0126 inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of PTGS2 protein]
nickel sulfate results in increased expression of PTGS2 protein
puerarin inhibits the reaction [nickel sulfate results in increased expression of PTGS2 protein]

PMID:16780908 PMID:18096868 PMID:18832182 PMID:20600219 PMID:26607348

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

prothymosin alpha

decreases expression

nickel sulfate results in decreased expression of PTMA mRNA

NCBI chr 1:86,454,442...86,458,434
Ensembl chr 1:86,454,448...86,458,434

G

protein tyrosine phosphatase, non-receptor type 18

increases expression

nickel sulfate results in increased expression of PTPN18 mRNA

NCBI chr 1:34,498,827...34,514,811
Ensembl chr 1:34,498,843...34,514,814

G

protein tyrosine phosphatase, non-receptor type 6

increases expression

nickel sulfate results in increased expression of PTPN6 mRNA

NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677

G

protein tyrosine phosphatase receptor type A

decreases expression

nickel sulfate results in decreased expression of PTPRA mRNA

NCBI chr 2:130,292,198...130,396,220
Ensembl chr 2:130,292,198...130,398,044

G

protein tyrosine phosphatase receptor type B

decreases expression

nickel sulfate results in decreased expression of PTPRB mRNA

NCBI chr10:116,111,407...116,225,443
Ensembl chr10:116,111,428...116,225,440

G

protein tyrosine phosphatase receptor type G

decreases expression

nickel sulfate results in decreased expression of PTPRG mRNA

NCBI chr14:10,227,722...10,916,341
Ensembl chr14:10,227,722...10,916,220

G

pumilio RNA-binding family member 3

decreases expression

nickel sulfate results in decreased expression of PUM3 mRNA

NCBI chr19:27,366,105...27,407,264
Ensembl chr19:27,366,098...27,407,225

G

PX domain containing 1

increases expression

nickel sulfate results in increased expression of PXDC1 mRNA

NCBI chr13:34,811,823...34,836,664
Ensembl chr13:34,811,817...34,837,469

G

2-phosphoxylose phosphatase 1

decreases expression

nickel sulfate results in decreased expression of PXYLP1 mRNA

NCBI chr 9:96,705,396...96,774,732
Ensembl chr 9:96,705,389...96,774,722

G

brain glycogen phosphorylase

decreases expression

nickel sulfate results in decreased expression of PYGB mRNA

NCBI chr 2:150,628,716...150,673,668
Ensembl chr 2:150,628,655...150,673,678

G

glutaminyl-peptide cyclotransferase (glutaminyl cyclase)

decreases expression

nickel sulfate results in decreased expression of QPCT mRNA

NCBI chr17:79,359,335...79,397,807
Ensembl chr17:79,359,335...79,397,807

G

RAB27B, member RAS oncogene family

increases expression

nickel sulfate results in increased expression of RAB27B mRNA

NCBI chr18:70,112,202...70,274,704
Ensembl chr18:70,112,202...70,274,676

G

RAB32, member RAS oncogene family

decreases expression

nickel sulfate results in decreased expression of RAB32 mRNA

PMID:16780908 PMID:17374397

NCBI chr10:10,420,783...10,433,951
Ensembl chr10:10,420,746...10,434,009

G

RAB3D, member RAS oncogene family

increases expression

nickel sulfate results in increased expression of RAB3D mRNA

NCBI chr 9:21,818,787...21,829,623
Ensembl chr 9:21,818,787...21,829,488

G

RAB42, member RAS oncogene family

decreases expression

nickel sulfate results in decreased expression of RAB42 mRNA

NCBI chr 4:132,027,749...132,030,693
Ensembl chr 4:132,029,508...132,030,696

G

RAB43, member RAS oncogene family

increases expression

nickel sulfate results in increased expression of RAB43 mRNA

NCBI chr 6:87,765,835...87,789,146
Ensembl chr 6:87,765,835...87,789,146

G

RAB8B, member RAS oncogene family

increases expression

nickel sulfate results in increased expression of RAB8B mRNA

NCBI chr 9:66,750,891...66,826,987
Ensembl chr 9:66,750,946...66,826,969

G

RAB9B, member RAS oncogene family

decreases expression

nickel sulfate results in decreased expression of RAB9B mRNA

NCBI chr X:135,758,896...135,769,305
Ensembl chr X:135,758,896...135,769,504

G

v-ral simian leukemia viral oncogene B

increases expression
decreases expression

nickel sulfate results in increased expression of RALB mRNA
nickel sulfate results in decreased expression of RALB mRNA

NCBI chr 1:119,398,035...119,432,512
Ensembl chr 1:119,398,035...119,432,524

G

Ral GTPase activating protein, alpha subunit 2 (catalytic)

decreases expression

nickel sulfate results in decreased expression of RALGAPA2 mRNA

NCBI chr 2:146,079,326...146,354,174
Ensembl chr 2:146,081,799...146,354,264

G

hnRNP-associated with lethal yellow

increases expression

nickel sulfate results in increased expression of RALY mRNA

NCBI chr 2:154,632,989...154,712,930
Ensembl chr 2:154,633,016...154,709,181

G

receptor (calcitonin) activity modifying protein 1

increases expression

nickel sulfate results in increased expression of RAMP1 mRNA

NCBI chr 1:91,107,544...91,152,918
Ensembl chr 1:91,107,544...91,152,918

G

RAN binding protein 6

decreases expression

nickel sulfate results in decreased expression of RANBP6 mRNA

NCBI chr19:29,785,508...29,790,374
Ensembl chr19:29,785,800...29,790,374

G

RAP1, GTP-GDP dissociation stimulator 1

decreases expression

nickel sulfate results in decreased expression of RAP1GDS1 mRNA

NCBI chr 3:138,631,662...138,781,163
Ensembl chr 3:138,631,663...138,780,962

G

RAS guanyl releasing protein 1

increases expression

nickel sulfate results in increased expression of RASGRP1 mRNA

NCBI chr 2:117,110,464...117,173,358
Ensembl chr 2:117,110,474...117,173,482

G

ribonucleoprotein, PTB-binding 2

increases expression

nickel sulfate results in increased expression of RAVER2 mRNA

NCBI chr 4:100,926,235...101,009,567
Ensembl chr 4:100,926,180...101,009,567

G

retinoblastoma binding protein 9, serine hydrolase

decreases expression

nickel sulfate results in decreased expression of RBBP9 mRNA

NCBI chr 2:144,384,185...144,392,779
Ensembl chr 2:144,384,185...144,392,789

G

RanBP-type and C3HC4-type zinc finger containing 1

decreases expression

nickel sulfate results in decreased expression of RBCK1 mRNA

NCBI chr 2:152,158,254...152,174,592
Ensembl chr 2:152,158,254...152,174,573

G

RNA binding motif protein 17

decreases expression

nickel sulfate results in decreased expression of RBM17 mRNA

PMID:16780908 PMID:17374397

NCBI chr 2:11,590,250...11,608,061
Ensembl chr 2:11,590,248...11,608,964

G

RNA binding motif protein 24

increases expression

nickel sulfate results in increased expression of RBM24 mRNA

NCBI chr13:46,571,664...46,584,575
Ensembl chr13:46,571,910...46,584,571

G

RNA binding motif, single stranded interacting protein

decreases expression

nickel sulfate results in decreased expression of RBMS3 mRNA

NCBI chr 9:116,401,814...117,869,900
Ensembl chr 9:116,401,814...117,701,749

G

recombination signal binding protein for immunoglobulin kappa J region

decreases expression

nickel sulfate results in decreased expression of RBPJ mRNA

PMID:17374397 PMID:22714537

NCBI chr 5:53,713,121...53,814,787
Ensembl chr 5:53,623,494...53,814,704

G

regulator of calcineurin 1

increases expression

nickel sulfate results in increased expression of RCAN1 mRNA

NCBI chr16:92,188,839...92,263,057
Ensembl chr16:92,188,841...92,267,755

G

recoverin

decreases expression

nickel sulfate results in decreased expression of RCVRN mRNA

NCBI chr11:67,586,152...67,594,181
Ensembl chr11:67,586,152...67,594,159

G

retinol dehydrogenase 11

decreases expression

nickel sulfate results in decreased expression of RDH11 mRNA

NCBI chr12:79,221,007...79,238,629
Ensembl chr12:79,221,111...79,239,067

G

reversion-inducing-cysteine-rich protein with kazal motifs

decreases expression

nickel sulfate results in decreased expression of RECK mRNA

NCBI chr 4:43,875,521...43,944,806
Ensembl chr 4:43,875,530...43,944,806

G

regenerating islet-derived 3 gamma

increases expression

nickel sulfate results in increased expression of REG3G mRNA

NCBI chr 6:78,443,252...78,445,857
Ensembl chr 6:78,443,252...78,445,855

G

reticuloendotheliosis oncogene

decreases expression
increases expression

nickel sulfate results in decreased expression of REL mRNA
nickel sulfate results in increased expression of REL mRNA

NCBI chr11:23,686,847...23,720,969
Ensembl chr11:23,686,847...23,720,970

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions
affects localization

[nickel sulfate results in increased degradation of NFKBIA protein] which results in increased activity of RELA protein; nickel sulfate results in increased phosphorylation of and affects the localization of RELA protein
nickel sulfate affects the localization of RELA protein
puerarin inhibits the reaction [nickel sulfate affects the localization of RELA protein]

PMID:17636246 PMID:25673294 PMID:26607348

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

RALBP1 associated Eps domain containing protein 2

increases expression

nickel sulfate results in increased expression of REPS2 mRNA

NCBI chr X:161,194,949...161,426,701
Ensembl chr X:161,194,950...161,426,645

G

retroelement silencing factor 1

increases expression

nickel sulfate results in increased expression of RESF1 mRNA

NCBI chr 6:149,210,907...149,237,161
Ensembl chr 6:149,210,912...149,237,161

G

resistin like alpha

increases expression

nickel sulfate results in increased expression of RETNLA mRNA

NCBI chr16:48,662,972...48,664,824
Ensembl chr16:48,662,914...48,664,824

G

reticulophagy regulator 1

increases expression

nickel sulfate results in increased expression of RETREG1 mRNA

NCBI chr15:25,840,795...25,973,782
Ensembl chr15:25,843,266...25,973,773

G

reticulophagy regulator family member 2

increases expression

nickel sulfate results in increased expression of RETREG2 mRNA

NCBI chr 1:75,119,432...75,124,553
Ensembl chr 1:75,119,422...75,124,557

G

ral guanine nucleotide dissociation stimulator,-like 1

decreases expression

nickel sulfate results in decreased expression of RGL1 mRNA

NCBI chr 1:152,392,513...152,642,056
Ensembl chr 1:152,392,511...152,642,102

G

ral guanine nucleotide dissociation stimulator-like 2

increases expression

nickel sulfate results in increased expression of RGL2 mRNA

NCBI chr17:34,148,813...34,156,661
Ensembl chr17:34,148,517...34,156,661

G

regulator of G-protein signaling 1

increases expression

nickel sulfate results in increased expression of RGS1 mRNA

PMID:16780908 PMID:17374397

NCBI chr 1:144,120,407...144,124,862
Ensembl chr 1:144,118,034...144,124,980

G

regulator of G-protein signaling 16

increases expression

nickel sulfate results in increased expression of RGS16 mRNA

NCBI chr 1:153,616,099...153,621,212
Ensembl chr 1:153,616,095...153,621,214

G

regulator of G-protein signaling 9

increases expression

nickel sulfate results in increased expression of RGS9 mRNA

NCBI chr11:109,116,174...109,189,013
Ensembl chr11:109,116,181...109,188,955

G

Ras homolog enriched in brain like 1

increases expression

nickel sulfate results in increased expression of RHEBL1 mRNA

NCBI chr15:98,775,659...98,779,424
Ensembl chr15:98,775,659...98,792,421

G

Rho-related BTB domain containing 1

decreases expression

nickel sulfate results in decreased expression of RHOBTB1 mRNA

NCBI chr10:68,987,106...69,127,621
Ensembl chr10:68,987,264...69,127,621

G

ras homolog family member C

increases expression

nickel sulfate results in increased expression of RHOC mRNA

NCBI chr 3:104,696,350...104,701,775
Ensembl chr 3:104,695,691...104,701,775

G

rhophilin, Rho GTPase binding protein 2

decreases expression

nickel sulfate results in decreased expression of RHPN2 mRNA

NCBI chr 7:35,033,605...35,091,712
Ensembl chr 7:35,033,595...35,091,714

G

RPTOR independent companion of MTOR, complex 2

increases expression

nickel sulfate results in increased expression of RICTOR mRNA

NCBI chr15:6,737,827...6,829,882
Ensembl chr15:6,737,860...6,829,882

G

receptor (TNFRSF)-interacting serine-threonine kinase 2

increases expression

nickel sulfate results in increased expression of RIPK2 mRNA

NCBI chr 4:16,122,740...16,163,674
Ensembl chr 4:16,122,733...16,163,647

G

receptor-interacting serine-threonine kinase 4

increases expression

nickel sulfate results in increased expression of RIPK4 mRNA

NCBI chr16:97,543,133...97,564,979
Ensembl chr16:97,543,133...97,564,987

G

Ras-like without CAAX 1

increases expression

nickel sulfate results in increased expression of RIT1 mRNA

NCBI chr 3:88,624,154...88,638,354
Ensembl chr 3:88,624,145...88,638,356

G

ribonuclease, RNase A family, 6

decreases expression

nickel sulfate results in decreased expression of RNASE6 mRNA

NCBI chr14:51,361,365...51,369,644
Ensembl chr14:51,361,365...51,369,644

G

ribonuclease T2A

increases expression

nickel sulfate results in increased expression of RNASET2 mRNA

NCBI chr17:8,347,412...8,367,078
Ensembl chr17:8,334,277...8,366,929

G

ring finger protein 157

increases expression

nickel sulfate results in increased expression of RNF157 mRNA

NCBI chr11:116,227,179...116,303,859
Ensembl chr11:116,227,179...116,303,858

G

ring finger protein 166

increases expression

nickel sulfate results in increased expression of RNF166 mRNA

NCBI chr 8:123,192,884...123,202,813
Ensembl chr 8:123,192,886...123,202,803

G

ring finger protein 213

increases expression

nickel sulfate results in increased expression of RNF213 mRNA

NCBI chr11:119,280,778...119,378,245
Ensembl chr11:119,283,926...119,378,244

G

ring finger protein 24

decreases expression

nickel sulfate results in decreased expression of RNF24 mRNA

NCBI chr 2:131,139,984...131,194,766
Ensembl chr 2:131,139,984...131,194,812

G

renalase, FAD-dependent amine oxidase

decreases expression

nickel sulfate results in decreased expression of RNLS mRNA

NCBI chr19:33,115,140...33,369,695
Ensembl chr19:33,115,147...33,369,665

G

arginyl aminopeptidase (aminopeptidase B)-like 1

increases expression

nickel sulfate results in increased expression of RNPEPL1 mRNA

NCBI chr 1:92,837,697...92,848,307
Ensembl chr 1:92,838,505...92,852,106

G

roundabout guidance receptor 2

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of ROBO2 mRNA

NCBI chr16:73,688,725...75,244,331
Ensembl chr16:73,688,727...74,889,765

G

ropporin 1-like

increases expression

nickel sulfate results in increased expression of ROPN1L mRNA

NCBI chr15:31,441,356...31,453,835
Ensembl chr15:31,441,357...31,453,883

G

receptor tyrosine kinase-like orphan receptor 1

decreases expression

nickel sulfate results in decreased expression of ROR1 mRNA

NCBI chr 4:99,952,988...100,302,003
Ensembl chr 4:99,952,988...100,301,962

G

ribosomal protein L10

decreases expression

nickel sulfate results in decreased expression of RPL10 mRNA

NCBI chr X:73,314,463...73,316,741
Ensembl chr X:73,314,418...73,316,741

G

ribosomal protein L23

decreases expression

nickel sulfate results in decreased expression of RPL23 mRNA

NCBI chr11:97,668,352...97,673,265
Ensembl chr11:97,668,353...97,673,263

G

ribosomal protein S6 kinase, polypeptide 5

increases expression

nickel sulfate results in increased expression of RPS6KA5 mRNA

NCBI chr12:100,514,692...100,691,693
Ensembl chr12:100,514,698...100,693,242

G

ribosomal protein S6 kinase, polypeptide 2

increases expression

nickel sulfate results in increased expression of RPS6KB2 mRNA

NCBI chr19:4,206,791...4,213,382
Ensembl chr19:4,203,990...4,213,353

G

ribosome binding protein 1

decreases expression

nickel sulfate results in decreased expression of RRBP1 mRNA

NCBI chr 2:143,789,315...143,853,216
Ensembl chr 2:143,789,315...143,853,183

G

rhotekin

increases expression

nickel sulfate results in increased expression of RTKN mRNA

NCBI chr 6:83,112,485...83,129,560
Ensembl chr 6:83,112,444...83,129,560

G

retrotransposon Gag like 3

decreases expression

nickel sulfate results in decreased expression of RTL3 mRNA

NCBI chr X:105,880,688...105,884,145
Ensembl chr X:105,880,688...105,884,250

G

RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein

increases expression

nickel sulfate results in increased expression of RUBCN mRNA

NCBI chr16:32,642,072...32,698,121
Ensembl chr16:32,642,073...32,698,136

G

retinoid X receptor beta

increases expression

nickel sulfate results in increased expression of RXRB mRNA

NCBI chr17:34,250,786...34,257,377
Ensembl chr17:34,250,786...34,257,373

G

S100 calcium binding protein A10 (calpactin)

increases expression

nickel sulfate results in increased expression of S100A10 mRNA

NCBI chr 3:93,462,424...93,471,952
Ensembl chr 3:93,462,387...93,471,950

G

S100 calcium binding protein A8 (calgranulin A)

affects expression

nickel sulfate affects the expression of S100A8 mRNA

NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342

G

S100 calcium binding protein A9 (calgranulin B)

increases expression

nickel sulfate results in increased expression of S100A9 mRNA

NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028

G

S100 protein, beta polypeptide, neural

decreases expression

nickel sulfate results in decreased expression of S100B mRNA

NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993

G

sphingosine-1-phosphate receptor 1

multiple interactions
decreases expression

[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in decreased expression of S1PR1 mRNA
nickel sulfate results in decreased expression of S1PR1 mRNA

PMID:18832182 PMID:22714537

NCBI chr 3:115,504,082...115,508,704
Ensembl chr 3:115,504,082...115,508,721

G

sphingosine-1-phosphate receptor 3

increases expression

nickel sulfate results in increased expression of S1PR3 mRNA

NCBI chr13:51,562,654...51,576,833
Ensembl chr13:51,562,675...51,576,833

G

serum amyloid A 1

increases expression

nickel sulfate results in increased expression of SAA1 mRNA

NCBI chr 7:46,389,921...46,392,404
Ensembl chr 7:46,389,921...46,392,404

G

serum amyloid A 2

increases expression

nickel sulfate results in increased expression of SAA2 mRNA

NCBI chr 7:46,401,257...46,403,737
Ensembl chr 7:46,401,214...46,403,737

G

serum amyloid A 3

increases expression

nickel sulfate results in increased expression of SAA3 mRNA

NCBI chr 7:46,361,422...46,365,100
Ensembl chr 7:46,361,422...46,365,124

G

SAC1 suppressor of actin mutations 1-like (yeast)

decreases expression

nickel sulfate results in decreased expression of SACM1L mRNA

NCBI chr 9:123,358,818...123,421,665
Ensembl chr 9:123,358,824...123,421,665

G

sacsin

decreases expression

nickel sulfate results in decreased expression of SACS mRNA

NCBI chr14:61,375,870...61,478,142
Ensembl chr14:61,375,906...61,478,144

G

SAM domain, SH3 domain and nuclear localization signals, 1

increases expression

nickel sulfate results in increased expression of SAMSN1 mRNA

NCBI chr16:75,655,682...75,706,154
Ensembl chr16:75,655,681...75,819,169

G

spermidine/spermine N1-acetyl transferase 1

increases expression

nickel sulfate results in increased expression of SAT1 mRNA

PMID:16780908 PMID:17374397

NCBI chr X:153,996,128...153,999,345
Ensembl chr X:153,996,128...153,999,445

G

special AT-rich sequence binding protein 1

increases expression

nickel sulfate results in increased expression of SATB1 mRNA

NCBI chr17:52,043,215...52,140,318
Ensembl chr17:52,043,215...52,140,318

G

special AT-rich sequence binding protein 2

increases expression

nickel sulfate results in increased expression of SATB2 mRNA

NCBI chr 1:56,833,145...57,019,350
Ensembl chr 1:56,833,140...57,017,809

G

spermine binding protein-like

increases expression

nickel sulfate results in increased expression of ZG16B mRNA

NCBI chr17:24,172,059...24,174,247
Ensembl chr17:24,172,058...24,174,248

G

sterol-C5-desaturase

increases expression

nickel sulfate results in increased expression of SC5D mRNA

NCBI chr 9:42,162,888...42,175,607
Ensembl chr 9:42,162,891...42,175,552

G

stearoyl-Coenzyme A desaturase 2

decreases expression
increases expression

nickel sulfate results in decreased expression of SCD2 mRNA
nickel sulfate results in increased expression of SCD mRNA

PMID:16100012 PMID:22714537

NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303

G

secretogranin II

increases expression

nickel sulfate results in increased expression of SCG2 mRNA

NCBI chr 1:79,412,083...79,417,743
Ensembl chr 1:79,412,386...79,417,837

G

secretoglobin, family 1A, member 1

affects expression

nickel sulfate affects the expression of SCGB1A1 mRNA

NCBI chr19:9,061,006...9,065,320
Ensembl chr19:9,061,000...9,065,322

G

syndecan 2

increases expression

nickel sulfate results in increased expression of SDC2 mRNA

PMID:16780908 PMID:17374397 PMID:22714537

NCBI chr15:32,920,869...33,034,867
Ensembl chr15:32,920,869...33,035,081

G

syndecan 4

increases expression

nickel sulfate results in increased expression of SDC4 mRNA

NCBI chr 2:164,266,167...164,285,512
Ensembl chr 2:164,266,167...164,285,807

G

short chain dehydrogenase/reductase family 42E, member 1

decreases expression

nickel sulfate results in decreased expression of SDR42E1 mRNA

NCBI chr 8:118,388,138...118,400,428
Ensembl chr 8:118,388,138...118,400,428

G

SEC23 homolog B, COPII coat complex component

decreases expression

nickel sulfate results in decreased expression of SEC23B mRNA

NCBI chr 2:144,398,165...144,432,673
Ensembl chr 2:144,398,149...144,432,669

G

SEC61 translocon subunit beta

increases expression

nickel sulfate results in increased expression of SEC61B mRNA

NCBI chr 4:47,474,661...47,483,233
Ensembl chr 4:47,474,658...47,483,242

G

SEC61 translocon subunit gamma

increases expression

nickel sulfate results in increased expression of SEC61G mRNA

NCBI chr11:16,451,638...16,458,484
Ensembl chr11:16,450,530...16,458,484

G

secreted and transmembrane 1A

decreases expression

nickel sulfate results in decreased expression of SECTM1 mRNA

NCBI chr11:120,958,221...120,988,023
Ensembl chr11:120,958,233...120,972,046

G

sel-1 suppressor of lin-12-like 3 (C. elegans)

decreases expression

nickel sulfate results in decreased expression of SEL1L3 mRNA

NCBI chr 5:53,264,425...53,370,794
Ensembl chr 5:53,264,425...53,371,269

G

selenoprotein K

increases expression

nickel sulfate results in increased expression of SELENOK mRNA

NCBI chr14:29,690,337...29,697,031
Ensembl chr14:29,690,265...29,697,619

G

selectin, platelet

increases expression

nickel sulfate results in increased expression of SELP mRNA

NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595

G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C

increases expression

nickel sulfate results in increased expression of SEMA4C mRNA

NCBI chr 1:36,587,720...36,599,780
Ensembl chr 1:36,587,720...36,597,430

G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

increases expression

nickel sulfate results in increased expression of SEMA4D mRNA

NCBI chr13:51,839,565...51,947,823
Ensembl chr13:51,839,565...51,947,783

G

sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A

increases expression

nickel sulfate results in increased expression of SEMA5A mRNA

NCBI chr15:32,244,959...32,696,487
Ensembl chr15:32,244,956...32,696,487

G

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B

increases expression

nickel sulfate results in increased expression of SEMA6B mRNA

NCBI chr17:56,430,085...56,447,343
Ensembl chr17:56,430,085...56,447,343

G

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

increases expression

nickel sulfate results in increased expression of SEMA6D mRNA

NCBI chr 2:123,931,089...124,509,711
Ensembl chr 2:123,931,889...124,509,690

G

sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A

decreases expression

nickel sulfate results in decreased expression of SEMA7A mRNA

NCBI chr 9:57,846,879...57,870,148
Ensembl chr 9:57,847,395...57,870,148

G

septin 11

decreases expression

nickel sulfate results in decreased expression of SEPTIN11 mRNA

NCBI chr 5:93,227,445...93,329,237
Ensembl chr 5:93,241,296...93,324,306

G

serpine1 mRNA binding protein 1

decreases expression

nickel sulfate results in decreased expression of SERBP1 mRNA

NCBI chr 6:67,243,963...67,266,286
Ensembl chr 6:67,215,160...67,274,720

G

stress-associated endoplasmic reticulum protein family member 2

decreases expression

nickel sulfate results in decreased expression of SERP2 mRNA

NCBI chr14:76,770,252...76,794,518
Ensembl chr14:76,770,254...76,794,329

G

serine (or cysteine) peptidase inhibitor, clade A, member 3C

increases expression

nickel sulfate results in increased expression of SERPINA3C mRNA

NCBI chr12:104,113,166...104,120,187
Ensembl chr12:104,112,641...104,120,129

G

serine (or cysteine) peptidase inhibitor, clade B, member 2

decreases expression

nickel sulfate results in decreased expression of SERPINB2 mRNA

NCBI chr 1:107,439,153...107,453,330
Ensembl chr 1:107,439,153...107,463,208

G

serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A

decreases expression

nickel sulfate results in decreased expression of SERPINB4 mRNA

NCBI chr 1:106,973,317...106,980,033
Ensembl chr 1:106,973,317...106,980,033

G

serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D

decreases expression

nickel sulfate results in decreased expression of SERPINB3 mRNA

NCBI chr 1:107,005,893...107,011,210
Ensembl chr 1:107,005,897...107,011,236

G

serine (or cysteine) peptidase inhibitor, clade B, member 7

decreases expression

nickel sulfate results in decreased expression of SERPINB7 mRNA

NCBI chr 1:107,350,418...107,380,419
Ensembl chr 1:107,327,385...107,380,419

G

serine (or cysteine) peptidase inhibitor, clade B, member 9

increases expression

nickel sulfate results in increased expression of SERPINB9 mRNA

NCBI chr13:33,181,044...33,201,938
Ensembl chr13:33,187,233...33,201,940

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

increases expression

nickel sulfate results in increased expression of SERPINE1 mRNA

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

serine (or cysteine) peptidase inhibitor, clade E, member 2

increases expression

nickel sulfate results in increased expression of SERPINE2 mRNA

NCBI chr 1:79,772,038...79,836,382
Ensembl chr 1:79,771,914...79,838,897

G

serine (or cysteine) peptidase inhibitor, clade H, member 1

decreases expression

nickel sulfate results in decreased expression of SERPINH1 mRNA

NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446

G

SEC14 and spectrin domains 1

increases expression

nickel sulfate results in increased expression of SESTD1 mRNA

NCBI chr 2:77,010,684...77,111,160
Ensembl chr 2:77,010,684...77,110,936

G

stratifin

increases expression

nickel sulfate results in increased expression of SFN mRNA

PMID:16100012 PMID:16166746

NCBI chr 4:133,327,867...133,329,163
Ensembl chr 4:133,327,867...133,329,479

G

splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)

increases expression

nickel sulfate results in increased expression of SFPQ mRNA

NCBI chr 4:126,914,504...126,944,894
Ensembl chr 4:126,915,117...126,930,806

G

surfactant associated protein A1

decreases expression

nickel sulfate results in decreased expression of SFTPA1 mRNA

NCBI chr14:40,853,745...40,858,330
Ensembl chr14:40,853,739...40,858,409

G

surfactant associated protein B

affects expression
decreases expression
multiple interactions
affects response to substance

nickel sulfate affects the expression of SFTPB mRNA
nickel sulfate results in decreased expression of SFTPB mRNA; nickel sulfate results in decreased expression of SFTPB protein
TGFA protein inhibits the reaction [nickel sulfate results in decreased expression of SFTPB protein]
SFTPB protein affects the susceptibility to nickel sulfate

PMID:11893692 PMID:11954676 PMID:12718980 PMID:19131640

NCBI chr 6:72,281,594...72,291,354
Ensembl chr 6:72,281,594...72,291,354

G

surfactant associated protein C

decreases expression
affects expression

nickel sulfate results in decreased expression of SFTPC mRNA
nickel sulfate affects the expression of SFTPC mRNA

PMID:11893692 PMID:12718980

NCBI chr14:70,758,381...70,761,521
Ensembl chr14:70,758,389...70,761,521

G

sideroflexin 2

decreases expression

nickel sulfate results in decreased expression of SFXN2 mRNA

NCBI chr19:46,561,798...46,585,340
Ensembl chr19:46,561,804...46,586,505

G

serum/glucocorticoid regulated kinase 1

increases expression

nickel sulfate results in increased expression of SGK1 mRNA

PMID:16780908 PMID:22714537

NCBI chr10:21,758,083...21,875,802
Ensembl chr10:21,758,083...21,875,802

G

sphingomyelin synthase 2

decreases expression

nickel sulfate results in decreased expression of SGMS2 mRNA

NCBI chr 3:131,112,634...131,197,204
Ensembl chr 3:131,112,634...131,197,172

G

small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha

increases expression

nickel sulfate results in increased expression of SGTA mRNA

NCBI chr10:80,879,905...80,896,105
Ensembl chr10:80,879,909...80,896,015

G

SH3-domain GRB2-like 1

increases expression

nickel sulfate results in increased expression of SH3GL1 mRNA

NCBI chr17:56,323,750...56,343,659
Ensembl chr17:56,323,750...56,343,635

G

SH3 and multiple ankyrin repeat domains 2

decreases expression

nickel sulfate results in decreased expression of SHANK2 mRNA

NCBI chr 7:143,531,819...143,979,780
Ensembl chr 7:143,555,665...143,978,231

G

shisa like 1

increases expression

nickel sulfate results in increased expression of SHISAL1 mRNA

NCBI chr15:84,263,404...84,367,061
Ensembl chr15:84,263,404...84,331,298

G

salt inducible kinase 1

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of SIK1 mRNA

NCBI chr17:32,063,222...32,074,808
Ensembl chr17:32,063,224...32,074,778

G

single-minded family bHLH transcription factor 1

increases expression

nickel sulfate results in increased expression of SIM1 mRNA

NCBI chr10:50,770,794...50,865,252
Ensembl chr10:50,770,850...50,865,248

G

SUMO-interacting motifs containing 1

increases expression

nickel sulfate results in increased expression of SIMC1 mRNA

NCBI chr13:54,651,539...54,699,103
Ensembl chr13:54,651,592...54,699,103

G

signal-regulatory protein alpha

decreases expression

nickel sulfate results in decreased expression of SIRPA mRNA

NCBI chr 2:129,432,962...129,474,148
Ensembl chr 2:129,434,755...129,474,148

G

src family associated phosphoprotein 2

increases expression

nickel sulfate results in increased expression of SKAP2 mRNA

NCBI chr 6:51,836,145...51,989,529
Ensembl chr 6:51,834,402...51,989,529

G

SKI2 subunit of superkiller complex

increases expression

nickel sulfate results in increased expression of SKIC2 mRNA

NCBI chr17:35,058,202...35,069,180
Ensembl chr17:35,058,204...35,069,186

G

SLAM family member 7

decreases expression

nickel sulfate results in decreased expression of SLAMF7 mRNA

NCBI chr 1:171,458,506...171,480,522
Ensembl chr 1:171,459,971...171,480,603

G

SLAM family member 8

decreases expression

nickel sulfate results in decreased expression of SLAMF8 mRNA

PMID:16780908 PMID:17374397

NCBI chr 1:172,408,944...172,418,482
Ensembl chr 1:172,409,325...172,418,135

G

solute carrier family 10 (sodium/bile acid cotransporter family), member 4

decreases expression

nickel sulfate results in decreased expression of SLC10A4 mRNA

NCBI chr 5:73,164,247...73,170,298
Ensembl chr 5:73,164,226...73,170,298

G

solute carrier family 12, member 7

increases expression

nickel sulfate results in increased expression of SLC12A7 mRNA

NCBI chr13:73,881,172...73,964,873
Ensembl chr13:73,881,213...73,964,873

G

solute carrier family 16 (monocarboxylic acid transporters), member 10

increases expression

nickel sulfate results in increased expression of SLC16A10 mRNA

PMID:16780908 PMID:17374397

NCBI chr10:39,909,528...40,018,262
Ensembl chr10:39,909,528...40,018,254

G

solute carrier family 16 (monocarboxylic acid transporters), member 12

decreases expression

nickel sulfate results in decreased expression of SLC16A12 mRNA

NCBI chr19:34,645,801...34,725,223
Ensembl chr19:34,645,803...34,724,689

G

solute carrier family 16 (monocarboxylic acid transporters), member 13

increases expression

nickel sulfate results in increased expression of SLC16A13 mRNA

NCBI chr11:70,107,615...70,113,638
Ensembl chr11:70,107,615...70,111,890

G

solute carrier family 18, subfamily B, member 1

increases expression

nickel sulfate results in increased expression of SLC18B1 mRNA

NCBI chr10:23,672,876...23,703,867
Ensembl chr10:23,672,884...23,703,866

G

solute carrier family 19 (thiamine transporter), member 2

decreases expression

nickel sulfate results in decreased expression of SLC19A2 mRNA

NCBI chr 1:164,076,615...164,092,954
Ensembl chr 1:164,076,615...164,092,954

G

solute carrier family 22, member 23

increases expression

nickel sulfate results in increased expression of SLC22A23 mRNA

NCBI chr13:34,363,141...34,530,666
Ensembl chr13:34,363,141...34,529,165

G

solute carrier family 23 (nucleobase transporters), member 2

multiple interactions
decreases expression

Ascorbic Acid inhibits the reaction [nickel sulfate results in decreased expression of SLC23A2 mRNA]

PMID:16288478 PMID:22714537

NCBI chr 2:131,894,416...131,987,287
Ensembl chr 2:131,894,416...131,987,028

G

solute carrier family 25, member 30

decreases expression

nickel sulfate results in decreased expression of SLC25A30 mRNA

NCBI chr14:75,994,986...76,024,477
Ensembl chr14:75,997,557...76,024,477

G

solute carrier family 29 (nucleoside transporters), member 4

increases expression

nickel sulfate results in increased expression of SLC29A4 mRNA

NCBI chr 5:142,678,226...142,708,245
Ensembl chr 5:142,678,267...142,708,245

G

solute carrier family 2 (facilitated glucose transporter), member 1

increases expression

nickel sulfate results in increased expression of SLC2A1 mRNA

NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180

G

solute carrier family 2 (facilitated glucose transporter), member 3

increases expression

nickel sulfate results in increased expression of SLC2A3 mRNA

PMID:16780908 PMID:17374397

NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599

G

solute carrier family 34 (sodium phosphate), member 2

decreases expression

nickel sulfate results in decreased expression of SLC34A2 mRNA

NCBI chr 5:53,206,695...53,229,006
Ensembl chr 5:53,195,423...53,229,006

G

solute carrier family 37 (glycerol-3-phosphate transporter), member 1

increases expression

nickel sulfate results in increased expression of SLC37A1 mRNA

NCBI chr17:31,495,722...31,569,683
Ensembl chr17:31,505,766...31,569,713

G

solute carrier family 37 (glycerol-3-phosphate transporter), member 3

decreases expression

nickel sulfate results in decreased expression of SLC37A3 mRNA

NCBI chr 6:39,311,704...39,354,659
Ensembl chr 6:39,311,707...39,354,609

G

solute carrier family 38, member 3

decreases expression

nickel sulfate results in decreased expression of SLC38A3 mRNA

NCBI chr 9:107,528,353...107,546,167
Ensembl chr 9:107,527,833...107,546,729

G

solute carrier family 38, member 5

decreases expression

nickel sulfate results in decreased expression of SLC38A5 mRNA

NCBI chr X:8,137,620...8,146,418
Ensembl chr X:8,137,372...8,146,418

G

solute carrier family 40 (iron-regulated transporter), member 1

increases expression

nickel sulfate results in increased expression of SLC40A1 mRNA

NCBI chr 1:45,947,230...45,965,690
Ensembl chr 1:45,947,228...45,965,683

G

solute carrier family 43, member 3

increases expression
decreases expression

nickel sulfate results in increased expression of SLC43A3 mRNA
nickel sulfate results in decreased expression of SLC43A3 mRNA

PMID:16780908 PMID:22714537

NCBI chr 2:84,766,943...84,788,853
Ensembl chr 2:84,766,923...84,788,853

G

solute carrier family 46, member 3

increases expression

nickel sulfate results in increased expression of SLC46A3 mRNA

NCBI chr 5:147,812,707...147,831,670
Ensembl chr 5:147,815,247...147,831,625

G

solute carrier family 47, member 1

increases expression

nickel sulfate results in increased expression of SLC47A1 mRNA

NCBI chr11:61,234,226...61,269,668
Ensembl chr11:61,234,227...61,269,171

G

solute carrier family 4, sodium bicarbonate transporter-like, member 11

decreases expression

nickel sulfate results in decreased expression of SLC4A11 mRNA

NCBI chr 2:130,526,027...130,539,439
Ensembl chr 2:130,526,033...130,539,439

G

solute carrier family 4 (anion exchanger), member 4

decreases expression

nickel sulfate results in decreased expression of SLC4A4 mRNA

NCBI chr 5:88,941,717...89,387,515
Ensembl chr 5:89,034,345...89,387,512

G

solute carrier family 66 member 3

increases expression

nickel sulfate results in increased expression of SLC66A3 mRNA

NCBI chr12:17,038,649...17,050,385
Ensembl chr12:17,038,649...17,050,409

G

solute carrier family 6 (neurotransmitter transporter, taurine), member 6

increases expression

nickel sulfate results in increased expression of SLC6A6 mRNA

NCBI chr 6:91,661,031...91,736,044
Ensembl chr 6:91,661,034...91,736,047

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 1

multiple interactions

[nickel sulfate co-treated with Lipopolysaccharides] results in increased expression of SLC7A1 mRNA

NCBI chr 5:148,264,220...148,336,714
Ensembl chr 5:148,264,220...148,336,714

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

increases expression

nickel sulfate results in increased expression of SLC7A11 mRNA

NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 3

multiple interactions

[nickel sulfate co-treated with Lipopolysaccharides] results in increased expression of SLC7A3 mRNA

NCBI chr X:100,122,752...100,134,058
Ensembl chr X:100,122,816...100,129,626

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 5

increases expression

nickel sulfate results in increased expression of SLC7A5 mRNA

PMID:16780908 PMID:17374397 PMID:18651567

NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 8

increases expression

nickel sulfate results in increased expression of SLC7A8 mRNA

NCBI chr14:54,959,672...55,019,343
Ensembl chr14:54,959,666...55,019,403

G

solute carrier family 8 (sodium/lithium/calcium exchanger), member B1

increases expression

nickel sulfate results in increased expression of SLC8B1 mRNA

NCBI chr 5:120,649,233...120,672,089
Ensembl chr 5:120,649,233...120,672,089

G

solute carrier organic anion transporter family, member 4a1

increases expression

nickel sulfate results in increased expression of SLCO4A1 mRNA

NCBI chr 2:180,098,019...180,116,646
Ensembl chr 2:180,098,038...180,116,660

G

slit guidance ligand 2

increases expression

nickel sulfate results in increased expression of SLIT2 mRNA

NCBI chr 5:48,138,633...48,465,077
Ensembl chr 5:48,140,480...48,465,075

G

SLX4 interacting protein

decreases expression

nickel sulfate results in decreased expression of SLX4IP mRNA

NCBI chr 2:136,733,138...136,923,273
Ensembl chr 2:136,733,138...136,913,870

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

decreases expression

nickel sulfate results in decreased expression of SMARCA2 mRNA

NCBI chr19:26,582,578...26,755,721
Ensembl chr19:26,582,450...26,755,722

G

structural maintenance of chromosomes 1A

decreases expression

nickel sulfate results in decreased expression of SMC1A mRNA

NCBI chr X:150,799,386...150,844,969
Ensembl chr X:150,799,424...150,845,690

G

sphingomyelin phosphodiesterase, acid-like 3A

decreases expression

nickel sulfate results in decreased expression of SMPDL3A mRNA

NCBI chr10:57,670,640...57,687,926
Ensembl chr10:57,670,431...57,687,926

G

SMAD specific E3 ubiquitin protein ligase 1

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of SMURF1 mRNA

NCBI chr 5:144,813,305...144,902,657
Ensembl chr 5:144,813,305...144,902,657

G

SET and MYND domain containing 3

decreases expression

nickel sulfate results in decreased expression of SMYD3 mRNA

NCBI chr 1:178,779,525...179,345,618
Ensembl chr 1:178,779,525...179,345,606

G

snail family zinc finger 1

increases expression

nickel sulfate results in increased expression of SNAI1 mRNA

NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734

G

synuclein, alpha

increases expression

nickel sulfate results in increased expression of SNCA mRNA

NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839

G

sushi, nidogen and EGF-like domains 1

increases expression

nickel sulfate results in increased expression of SNED1 mRNA

NCBI chr 1:93,163,563...93,228,787
Ensembl chr 1:93,163,563...93,228,787

G

small nucleolar RNA, H/ACA box 24

decreases expression

nickel sulfate results in decreased expression of SNORA24 mRNA

NCBI chr 3:123,301,586...123,301,715
Ensembl chr 3:123,301,586...123,301,715

G

small nucleolar RNA, C/D box 1C

decreases expression

nickel sulfate results in decreased expression of SNORD1C mRNA

NCBI chr11:116,563,331...116,563,408
Ensembl chr11:116,563,332...116,563,407

G

small nucleolar RNA, C/D box 45C

decreases expression

nickel sulfate results in decreased expression of SNORD45C mRNA

NCBI chr 3:153,617,766...153,617,826
Ensembl chr 3:153,617,762...153,617,841

G

small nucleolar RNA, C/D box 60

decreases expression

nickel sulfate results in decreased expression of SNORD60 mRNA

NCBI chr17:24,747,450...24,747,527
Ensembl chr17:24,747,450...24,747,527

G

small nuclear ribonucleoprotein B

increases expression

nickel sulfate results in increased expression of SNRPB mRNA

NCBI chr 2:130,013,560...130,031,184
Ensembl chr 2:130,013,555...130,021,323

G

U2 small nuclear ribonucleoprotein B

decreases expression

nickel sulfate results in decreased expression of SNRPB2 mRNA

NCBI chr 2:142,904,989...142,913,972
Ensembl chr 2:142,904,959...142,914,773

G

sorting nexin 10

increases expression

nickel sulfate results in increased expression of SNX10 mRNA

NCBI chr 6:51,500,882...51,567,659
Ensembl chr 6:51,500,881...51,567,659

G

sorting nexin 14

increases expression

nickel sulfate results in increased expression of SNX14 mRNA

NCBI chr 9:88,258,805...88,320,982
Ensembl chr 9:88,258,800...88,321,011

G

sorting nexin 5

decreases expression

nickel sulfate results in decreased expression of SNX5 mRNA

NCBI chr 2:144,092,043...144,112,713
Ensembl chr 2:144,092,043...144,112,826

G

sorting nexin 9

increases expression

nickel sulfate results in increased expression of SNX9 mRNA

NCBI chr17:5,891,599...5,982,231
Ensembl chr17:5,891,604...5,982,229

G

suppressor of cytokine signaling 3

increases expression

nickel sulfate results in increased expression of SOCS3 mRNA

NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873

G

superoxide dismutase 1, soluble

increases expression
decreases activity

nickel sulfate results in increased expression of SOD1 mRNA
nickel sulfate results in decreased activity of SOD1 protein

PMID:20566472 PMID:35499276

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

increases expression

nickel sulfate results in increased expression of SOD2 mRNA

PMID:16314067 PMID:16780908 PMID:20566472

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

superoxide dismutase 3, extracellular

increases expression

nickel sulfate results in increased expression of SOD3 mRNA

NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760

G

sortilin-related receptor, LDLR class A repeats-containing

increases expression

nickel sulfate results in increased expression of SORL1 mRNA

NCBI chr 9:41,876,005...42,035,593
Ensembl chr 9:41,876,016...42,035,593

G

SRY (sex determining region Y)-box 9

increases expression

nickel sulfate results in increased expression of SOX9 mRNA

NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586

G

trans-acting transcription factor 3

increases expression

nickel sulfate results in increased expression of SP3 mRNA

NCBI chr 2:72,766,774...72,810,790
Ensembl chr 2:72,766,771...72,810,790

G

sphingosine kinase 1

multiple interactions
increases expression

[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of SPHK1 mRNA
nickel sulfate results in increased expression of SPHK1 mRNA

NCBI chr11:116,421,662...116,427,502
Ensembl chr11:116,421,751...116,427,501

G

serine protease inhibitor, Kunitz type 2

decreases expression

nickel sulfate results in decreased expression of SPINT2 mRNA

NCBI chr 7:28,955,755...28,981,484
Ensembl chr 7:28,955,748...28,981,337

G

sperm associated microtubule inner protein 4

increases expression

nickel sulfate results in increased expression of SPMIP4 mRNA

NCBI chr 6:50,550,282...50,573,847
Ensembl chr 6:50,550,282...50,573,612

G

sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1

increases expression

nickel sulfate results in increased expression of SPOCK1 mRNA

NCBI chr13:57,569,008...58,056,194
Ensembl chr13:57,569,008...58,056,146

G

secreted phosphoprotein 1

increases expression

nickel sulfate results in increased expression of SPP1 mRNA

NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916

G

small proline-rich protein 1A

increases expression

nickel sulfate results in increased expression of SPRR1A mRNA

NCBI chr 3:92,391,261...92,393,188
Ensembl chr 3:92,391,259...92,393,202

G

sprouty RTK signaling antagonist 3

decreases expression

nickel sulfate results in decreased expression of SPRY3 mRNA

G

spectrin alpha, erythrocytic 1

increases expression

nickel sulfate results in increased expression of SPTA1 mRNA

NCBI chr 1:174,000,305...174,076,015
Ensembl chr 1:174,000,342...174,076,016

G

serine palmitoyltransferase, long chain base subunit 3

decreases expression

nickel sulfate results in decreased expression of SPTLC3 mRNA

NCBI chr 2:139,335,833...139,478,981
Ensembl chr 2:139,335,833...139,479,594

G

sulfide quinone oxidoreductase

increases expression

nickel sulfate results in increased expression of SQOR mRNA

NCBI chr 2:122,607,249...122,651,473
Ensembl chr 2:122,607,157...122,651,489

G

Rous sarcoma oncogene

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of SRC mRNA

NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782

G

SLIT-ROBO Rho GTPase activating protein 1

increases expression

nickel sulfate results in increased expression of SRGAP1 mRNA

NCBI chr10:121,616,896...121,883,740
Ensembl chr10:121,616,896...121,883,220

G

signal recognition particle 72

decreases expression

nickel sulfate results in decreased expression of SRP72 mRNA

PMID:17374397 PMID:18651567

NCBI chr 5:77,122,548...77,147,782
Ensembl chr 5:77,122,530...77,147,784

G

serine racemase

increases expression

nickel sulfate results in increased expression of SRR mRNA

NCBI chr11:74,794,853...74,818,427
Ensembl chr11:74,797,185...74,816,774

G

serine and arginine-rich splicing factor 5

increases expression

nickel sulfate results in increased expression of SRSF5 mRNA

NCBI chr12:80,992,308...80,997,277
Ensembl chr12:80,992,278...80,997,281

G

sulfiredoxin 1 homolog (S. cerevisiae)

increases expression
decreases expression

nickel sulfate results in increased expression of SRXN1 mRNA
nickel sulfate results in decreased expression of SRXN1 mRNA

PMID:20566472 PMID:22714537

NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296

G

single-stranded DNA binding protein 2

decreases expression

nickel sulfate results in decreased expression of SSBP2 mRNA

NCBI chr13:91,608,449...91,854,299
Ensembl chr13:91,608,402...91,851,548

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 4

increases expression

nickel sulfate results in increased expression of ST3GAL4 mRNA

NCBI chr 9:34,957,872...35,028,160
Ensembl chr 9:34,957,872...35,030,564

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

increases expression

nickel sulfate results in increased expression of ST3GAL6 mRNA

NCBI chr16:58,290,105...58,344,614
Ensembl chr16:58,288,488...58,344,606

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6

increases expression

nickel sulfate results in increased expression of ST8SIA6 mRNA

NCBI chr 2:13,659,745...13,798,659
Ensembl chr 2:13,655,832...13,798,875

G

src homology three (SH3) and cysteine rich domain

decreases expression

nickel sulfate results in decreased expression of STAC mRNA

NCBI chr 9:111,386,476...111,519,673
Ensembl chr 9:111,390,505...111,519,416

G

STAM binding protein like 1

decreases expression

nickel sulfate results in decreased expression of STAMBPL1 mRNA

NCBI chr19:34,169,629...34,217,733
Ensembl chr19:34,169,629...34,217,733

G

steroidogenic acute regulatory protein

multiple interactions
decreases expression

[CGA protein co-treated with nickel sulfate] results in decreased expression of STAR mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of STAR protein; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of STAR protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of STAR protein]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of STAR protein]; TEMPO inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA]; TEMPO inhibits the reaction [nickel sulfate results in decreased expression of STAR protein]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of STAR protein]
nickel sulfate results in decreased expression of STAR mRNA; nickel sulfate results in decreased expression of STAR protein

NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010

G

signal transducer and activator of transcription 1

decreases expression
multiple interactions
increases phosphorylation

nickel sulfate results in decreased expression of STAT1 mRNA
Acetylcysteine inhibits the reaction [nickel sulfate results in increased phosphorylation of STAT1 protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased phosphorylation of STAT1 protein]
Quercetin inhibits the reaction [nickel sulfate results in increased phosphorylation of STAT1 protein]

PMID:17374397 PMID:20525893 PMID:25957741

NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024

G

signal transducer and activator of transcription 4

increases expression

nickel sulfate results in increased expression of STAT4 mRNA

PMID:16780908 PMID:17374397

NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348

G

signal transducer and activator of transcription 5A

increases expression

nickel sulfate results in increased expression of STAT5A mRNA

NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995

G

signal transducer and activator of transcription 5B

increases expression
multiple interactions

nickel sulfate results in increased expression of STAT5B mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of STAT5B mRNA

PMID:17374397 PMID:31734292

NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550

G

stanniocalcin 1

increases expression

nickel sulfate results in increased expression of STC1 mRNA

NCBI chr14:69,266,738...69,278,850
Ensembl chr14:69,266,687...69,279,253

G

six transmembrane epithelial antigen of prostate 2

increases expression

nickel sulfate results in increased expression of STEAP2 mRNA

NCBI chr 5:5,714,829...5,744,649
Ensembl chr 5:5,714,829...5,744,578

G

STEAP family member 3

increases expression

nickel sulfate results in increased expression of STEAP3 mRNA

NCBI chr 1:120,154,137...120,198,810
Ensembl chr 1:120,118,487...120,200,435

G

serine/threonine kinase 16

increases expression

nickel sulfate results in increased expression of STK16 mRNA

NCBI chr 1:75,187,463...75,192,250
Ensembl chr 1:75,187,482...75,192,250

G

serine/threonine kinase 19

increases expression

nickel sulfate results in increased expression of STK19 mRNA

NCBI chr17:35,042,969...35,055,879
Ensembl chr17:35,042,969...35,055,921

G

serine/threonine kinase 33

decreases expression

nickel sulfate results in decreased expression of STK33 mRNA

NCBI chr 7:108,878,270...109,038,375
Ensembl chr 7:108,878,430...109,038,288

G

serine/threonine kinase 35

decreases expression

nickel sulfate results in decreased expression of STK35 mRNA

NCBI chr 2:129,642,437...129,674,207
Ensembl chr 2:129,642,437...129,674,207

G

serine/threonine kinase 38 like

increases expression

nickel sulfate results in increased expression of STK38L mRNA

NCBI chr 6:146,626,428...146,680,312
Ensembl chr 6:146,626,493...146,680,310

G

storkhead box 1

increases expression

nickel sulfate results in increased expression of STOX1 mRNA

NCBI chr10:62,494,822...62,561,907
Ensembl chr10:62,494,822...62,561,907

G

storkhead box 2

increases expression

nickel sulfate results in increased expression of STOX2 mRNA

NCBI chr 8:47,633,083...47,866,943
Ensembl chr 8:47,633,083...47,899,397

G

steroid sulfatase

decreases expression

nickel sulfate results in decreased expression of STS mRNA

NCBI chr X:168,856,332...169,015,037
Ensembl chr X:168,909,030...169,014,924

G

syntaxin 11

increases expression

nickel sulfate results in increased expression of STX11 mRNA

PMID:16780908 PMID:17374397

NCBI chr10:12,813,961...12,840,242
Ensembl chr10:12,813,953...12,840,042

G

syntaxin 1B

increases expression

nickel sulfate results in increased expression of STX1B mRNA

NCBI chr 7:127,403,072...127,423,703
Ensembl chr 7:127,403,072...127,423,721

G

syntaxin binding protein 2

increases expression

nickel sulfate results in increased expression of STXBP2 mRNA

NCBI chr 8:3,680,960...3,693,998
Ensembl chr 8:3,680,955...3,693,644

G

syntaxin binding protein 6 (amisyn)

decreases expression

nickel sulfate results in decreased expression of STXBP6 mRNA

NCBI chr12:44,899,267...45,121,248
Ensembl chr12:44,899,267...45,121,492

G

SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)

decreases expression
increases expression

nickel sulfate results in decreased expression of SUGT1 mRNA
nickel sulfate results in increased expression of SUGT1 mRNA

NCBI chr14:79,825,100...79,868,237
Ensembl chr14:79,825,131...79,872,636

G

sulfatase 1

increases expression

nickel sulfate results in increased expression of SULF1 mRNA

NCBI chr 1:12,762,421...12,946,090
Ensembl chr 1:12,762,501...12,931,416

G

sulfatase 2

decreases expression

nickel sulfate results in decreased expression of SULF2 mRNA

NCBI chr 2:165,915,819...165,997,603
Ensembl chr 2:165,915,009...165,997,583

G

sushi domain containing 1

decreases expression

nickel sulfate results in decreased expression of SUSD1 mRNA

NCBI chr 4:59,314,190...59,438,738
Ensembl chr 4:59,314,683...59,438,633

G

synaptotagmin-like 2

decreases expression

nickel sulfate results in decreased expression of SYTL2 mRNA

NCBI chr 7:89,951,421...90,059,927
Ensembl chr 7:89,951,460...90,059,927

G

tachykinin 2

increases expression

nickel sulfate results in increased expression of TAC3 mRNA

NCBI chr10:127,560,347...127,567,637
Ensembl chr10:127,560,347...127,567,637

G

TATA-box binding protein associated factor, RNA polymerase I, B

decreases expression

nickel sulfate results in decreased expression of TAF1B mRNA

NCBI chr12:24,548,580...24,608,570
Ensembl chr12:24,548,358...24,608,538

G

transgelin

decreases expression

nickel sulfate results in decreased expression of TAGLN mRNA

NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356

G

transport and golgi organization 2

increases expression

nickel sulfate results in increased expression of TANGO2 mRNA

NCBI chr16:18,118,689...18,165,962
Ensembl chr16:18,118,689...18,165,967

G

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

increases expression
multiple interactions

nickel sulfate results in increased expression of TAP1 mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of TAP1 mRNA

PMID:22714537 PMID:31734292

NCBI chr17:34,406,530...34,416,199
Ensembl chr17:34,406,527...34,416,199

G

TAP binding protein

increases expression

nickel sulfate results in increased expression of TAPBP mRNA

NCBI chr17:34,138,452...34,148,264
Ensembl chr17:34,134,873...34,148,266

G

taste receptor, type 2, member 114

decreases expression

nickel sulfate results in decreased expression of TAS2R10 mRNA

NCBI chr 6:131,666,097...131,667,026
Ensembl chr 6:131,666,097...131,667,026

G

taspase, threonine aspartase 1

decreases expression

nickel sulfate results in decreased expression of TASP1 mRNA

NCBI chr 2:139,675,399...139,908,767
Ensembl chr 2:139,675,400...139,908,725

G

TBC1 domain family, member 13

increases expression

nickel sulfate results in increased expression of TBC1D13 mRNA

NCBI chr 2:30,023,742...30,042,024
Ensembl chr 2:30,023,758...30,042,025

G

TBC1 domain family, member 20

decreases expression

nickel sulfate results in decreased expression of TBC1D20 mRNA

NCBI chr 2:152,135,745...152,155,914
Ensembl chr 2:152,135,748...152,155,916

G

transcription elongation factor A (SII), 3

decreases expression

nickel sulfate results in decreased expression of TCEA3 mRNA

NCBI chr 4:135,975,253...136,002,214
Ensembl chr 4:135,975,040...136,002,209

G

transcription factor 25 (basic helix-loop-helix)

increases expression

nickel sulfate results in increased expression of TCF25 mRNA

NCBI chr 8:124,097,511...124,130,913
Ensembl chr 8:124,100,492...124,130,574

G

transcription factor 4

decreases expression
increases expression

nickel sulfate results in decreased expression of TCF4 mRNA
nickel sulfate results in increased expression of TCF4 mRNA

PMID:16780908 PMID:22714537

NCBI chr18:69,476,500...69,821,038
Ensembl chr18:69,476,427...69,822,150

G

transcription factor 7 like 1 (T cell specific, HMG box)

increases expression

nickel sulfate results in increased expression of TCF7L1 mRNA

NCBI chr 6:72,603,354...72,766,028
Ensembl chr 6:72,603,361...72,766,237

G

tectonic family member 1

increases expression

nickel sulfate results in increased expression of TCTN1 mRNA

NCBI chr 5:122,377,558...122,402,557
Ensembl chr 5:122,375,911...122,402,523

G

tec protein tyrosine kinase

decreases expression

nickel sulfate results in decreased expression of TEC mRNA

NCBI chr 5:72,913,061...73,025,997
Ensembl chr 5:72,913,059...73,025,826

G

teneurin transmembrane protein 3

decreases expression

nickel sulfate results in decreased expression of TENM3 mRNA

NCBI chr 8:48,678,700...51,370,255
Ensembl chr 8:48,680,717...49,296,986

G

telomerase RNA component

decreases expression

nickel sulfate results in decreased expression of TERC mRNA

NCBI chr 3:96,321,753...96,322,149
Ensembl chr 3:96,321,753...96,322,149

G

testin LIM domain protein

decreases expression

nickel sulfate results in decreased expression of TES mRNA

NCBI chr 6:17,065,148...17,105,824
Ensembl chr 6:17,065,148...17,105,827

G

transcription factor AP-2, gamma

increases expression

nickel sulfate results in increased expression of TFAP2C mRNA

NCBI chr 2:172,387,599...172,400,542
Ensembl chr 2:172,391,513...172,400,542

G

transcription factor E3

decreases expression

nickel sulfate results in decreased expression of TFE3 mRNA

NCBI chr X:7,628,769...7,641,441
Ensembl chr X:7,628,799...7,641,441

G

tissue factor pathway inhibitor 2

increases expression

nickel sulfate results in increased expression of TFPI2 mRNA

NCBI chr 6:3,962,589...3,988,977
Ensembl chr 6:3,962,595...3,988,919

G

transferrin receptor 2

increases expression

nickel sulfate results in increased expression of TFR2 mRNA

NCBI chr 5:137,568,127...137,586,344
Ensembl chr 5:137,568,102...137,585,743

G

transferrin receptor

increases expression

nickel sulfate results in increased expression of TFRC mRNA

NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612

G

transforming growth factor alpha

affects response to substance
multiple interactions

TGFA protein affects the susceptibility to nickel sulfate
[TGFA protein binds to and affects the activity of EGFR protein] which results in decreased susceptibility to nickel sulfate; TGFA protein inhibits the reaction [nickel sulfate results in decreased expression of SFTPB protein]
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of TGFA mRNA

PMID:11954676 PMID:19131640 PMID:31734292

NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701

G

transforming growth factor, beta 1

increases expression
increases secretion
decreases expression

nickel sulfate results in increased expression of TGFB1 mRNA
nickel sulfate results in increased secretion of TGFB1 protein
nickel sulfate results in decreased expression of TGFB1 mRNA; nickel sulfate results in decreased expression of TGFB1 protein

PMID:15347381 PMID:16100012 PMID:18832182 PMID:35499276

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

transforming growth factor, beta receptor I

decreases expression

nickel sulfate results in decreased expression of TGFBR1 mRNA

PMID:18832182 PMID:22714537

NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931

G

transforming growth factor, beta receptor II

decreases expression

nickel sulfate results in decreased expression of TGFBR2 mRNA

NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428

G

TGFB-induced factor homeobox 1

increases expression

nickel sulfate results in increased expression of TGIF1 mRNA

NCBI chr17:71,151,200...71,160,527
Ensembl chr17:71,151,200...71,160,541

G

trans-golgi network protein

decreases expression

nickel sulfate results in decreased expression of TGOLN2 mRNA

NCBI chr 6:72,585,403...72,593,983
Ensembl chr 6:72,585,415...72,593,983

G

thrombospondin 1

increases expression

nickel sulfate results in increased expression of THBS1 mRNA

NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614

G

thrombospondin 2

multiple interactions
increases expression

[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of THBS2 mRNA
nickel sulfate results in increased expression of THBS2 mRNA

NCBI chr17:14,885,762...14,914,524
Ensembl chr17:14,885,762...14,914,497

G

threonine synthase-like 1 (bacterial)

decreases expression

nickel sulfate results in decreased expression of THNSL1 mRNA

NCBI chr 2:21,210,236...21,232,948
Ensembl chr 2:21,210,535...21,219,820

G

threonine synthase-like 2 (bacterial)

decreases expression

nickel sulfate results in decreased expression of THNSL2 mRNA

NCBI chr 6:71,105,150...71,121,364
Ensembl chr 6:71,105,150...71,121,423

G

thrombospondin, type I, domain containing 4

decreases expression

nickel sulfate results in decreased expression of THSD4 mRNA

NCBI chr 9:59,874,214...60,429,394
Ensembl chr 9:59,874,214...60,429,329

G

thymus cell antigen 1, theta

decreases expression

nickel sulfate results in decreased expression of THY1 mRNA

NCBI chr 9:43,954,681...43,959,876
Ensembl chr 9:43,954,681...43,959,876

G

T cell lymphoma invasion and metastasis 1

increases expression

nickel sulfate results in increased expression of TIAM1 mRNA

NCBI chr16:89,583,999...89,942,488
Ensembl chr16:89,583,999...89,940,657

G

tissue inhibitor of metalloproteinase 1

increases expression

nickel sulfate results in increased expression of TIMP1 mRNA

PMID:11114790 PMID:16100012 PMID:16780908

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tissue inhibitor of metalloproteinase 2

increases expression

nickel sulfate results in increased expression of TIMP2 mRNA

NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566

G

tissue inhibitor of metalloproteinase 3

increases expression
decreases expression

nickel sulfate results in increased expression of TIMP3 mRNA
nickel sulfate results in decreased expression of TIMP3 mRNA

PMID:16314067 PMID:22714537

NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370

G

TCDD-inducible poly(ADP-ribose) polymerase

increases expression

nickel sulfate results in increased expression of TIPARP mRNA

NCBI chr 3:65,435,868...65,462,939
Ensembl chr 3:65,435,831...65,462,939

G

TLC domain containing 1

increases expression

nickel sulfate results in increased expression of TLCD1 mRNA

NCBI chr11:78,068,956...78,071,646
Ensembl chr11:78,067,537...78,072,735

G

transducin-like enhancer of split 4

increases expression

nickel sulfate results in increased expression of TLE4 mRNA

NCBI chr19:14,425,434...14,575,542
Ensembl chr19:14,425,514...14,575,415

G

talin 2

decreases expression
increases expression

nickel sulfate results in decreased expression of TLN2 mRNA
nickel sulfate results in increased expression of TLN2 mRNA

NCBI chr 9:67,124,371...67,541,357
Ensembl chr 9:67,124,369...67,466,985

G

toll-like receptor 3

increases expression

nickel sulfate results in increased expression of TLR3 mRNA

NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117

G

toll-like receptor 4

increases expression
multiple interactions

nickel sulfate results in increased expression of TLR4 protein
puerarin inhibits the reaction [nickel sulfate results in increased expression of TLR4 protein]
TLR4 protein affects the reaction [nickel sulfate results in increased expression of EBI3 mRNA]; TLR4 protein affects the reaction [nickel sulfate results in increased expression of IL27 mRNA]

PMID:26607348 PMID:30421605

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

transmembrane 4 superfamily member 1

decreases expression

nickel sulfate results in decreased expression of TM4SF1 mRNA

NCBI chr 3:57,193,038...57,295,150
Ensembl chr 3:57,193,032...57,209,409
Ensembl chr 3:57,193,032...57,209,409

G

transmembrane 4 L six family member 19

increases expression

nickel sulfate results in increased expression of TM4SF19 mRNA

NCBI chr16:32,218,823...32,227,397
Ensembl chr16:32,219,324...32,227,045

G

translational machinery associated 7

decreases expression

nickel sulfate results in decreased expression of TMA7 mRNA

NCBI chr 9:108,907,056...108,911,449
Ensembl chr 9:108,903,636...108,911,655

G

transmembrane and coiled coil domains 3

increases expression

nickel sulfate results in increased expression of TMCC3 mRNA

NCBI chr10:94,147,544...94,426,816
Ensembl chr10:94,147,811...94,426,818

G

transmembrane protein 117

decreases expression

nickel sulfate results in decreased expression of TMEM117 mRNA

NCBI chr15:94,527,066...94,993,978
Ensembl chr15:94,527,113...94,993,979

G

transmembrane protein 171

increases expression

nickel sulfate results in increased expression of TMEM171 mRNA

NCBI chr13:98,822,744...98,832,142
Ensembl chr13:98,822,743...98,831,342

G

transmembrane protein 215

decreases expression

nickel sulfate results in decreased expression of TMEM215 mRNA

NCBI chr 4:40,472,180...40,475,653
Ensembl chr 4:40,472,180...40,477,168

G

transmembrane protein 230

decreases expression

nickel sulfate results in decreased expression of TMEM230 mRNA

NCBI chr 2:132,081,412...132,089,708
Ensembl chr 2:132,081,412...132,089,727

G

transmembrane protein 255A

decreases expression

nickel sulfate results in decreased expression of TMEM255A mRNA

NCBI chr X:37,285,450...37,341,373
Ensembl chr X:37,285,450...37,341,316

G

transmembrane protein 45a

increases expression

nickel sulfate results in increased expression of TMEM45A mRNA

NCBI chr16:56,625,524...56,706,648
Ensembl chr16:56,625,524...56,706,529

G

transmembrane protein 52B

increases expression

nickel sulfate results in increased expression of TMEM52B mRNA

NCBI chr 6:129,489,512...129,496,190
Ensembl chr 6:129,489,518...129,496,190

G

tropomodulin 1

increases expression

nickel sulfate results in increased expression of TMOD1 mRNA

NCBI chr 4:46,038,940...46,116,032
Ensembl chr 4:46,038,935...46,116,032

G

tropomodulin 2

decreases expression

nickel sulfate results in decreased expression of TMOD2 mRNA

NCBI chr 9:75,472,903...75,518,620
Ensembl chr 9:75,472,903...75,518,607

G

transmembrane protease, serine 15

decreases expression

nickel sulfate results in decreased expression of TMPRSS15 mRNA

NCBI chr16:78,749,896...78,887,988
Ensembl chr16:78,749,896...78,887,985

G

thymosin beta 10

increases expression

nickel sulfate results in increased expression of TMSB10 mRNA

NCBI chr 6:72,934,330...72,935,731
Ensembl chr 6:72,934,330...72,935,731

G

thioredoxin-related transmembrane protein 4

decreases expression

nickel sulfate results in decreased expression of TMX4 mRNA

NCBI chr 2:134,436,421...134,486,041
Ensembl chr 2:134,436,105...134,486,065

G

tenascin C

increases expression
decreases expression

nickel sulfate results in increased expression of TNC mRNA
nickel sulfate results in decreased expression of TNC mRNA

PMID:16100012 PMID:22714537

NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252

G

tumor necrosis factor

decreases response to substance
multiple interactions
affects expression
increases secretion
increases expression

TNF protein results in decreased susceptibility to nickel sulfate
[Tetradecanoylphorbol Acetate co-treated with nickel sulfate] results in increased expression of and results in increased secretion of TNF protein; SB 203580 inhibits the reaction [nickel sulfate results in increased expression of TNF protein]; TNF protein affects the reaction [nickel sulfate results in increased secretion of CCL20 protein]; TNF protein affects the reaction [nickel sulfate results in increased secretion of CXCL8 protein]; TNF protein promotes the reaction [nickel sulfate results in increased expression of CD83 protein]; U 0126 inhibits the reaction [nickel sulfate results in increased expression of TNF protein]
nickel sulfate affects the expression of TNF mRNA
nickel sulfate results in increased secretion of TNF protein
nickel sulfate results in increased expression of TNF mRNA; nickel sulfate results in increased expression of TNF protein
puerarin inhibits the reaction [nickel sulfate results in increased expression of TNF protein]; Quercetin inhibits the reaction [nickel sulfate results in increased expression of TNF protein]

PMID:10929769 PMID:11893692 PMID:15679580 PMID:16099135 PMID:17118622 More...

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor, alpha-induced protein 2

increases expression

nickel sulfate results in increased expression of TNFAIP2 mRNA

NCBI chr12:111,408,898...111,421,452
Ensembl chr12:111,408,903...111,421,452

G

tumor necrosis factor, alpha-induced protein 3

increases expression

nickel sulfate results in increased expression of TNFAIP3 mRNA

PMID:16780908 PMID:18651567 PMID:20146380 PMID:20713136

NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405

G

tumor necrosis factor alpha induced protein 6

increases expression

nickel sulfate results in increased expression of TNFAIP6 mRNA

PMID:17374397 PMID:20713136

NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698

G

tumor necrosis factor receptor superfamily, member 12a

increases expression

nickel sulfate results in increased expression of TNFRSF12A mRNA

NCBI chr17:23,894,419...23,896,423
Ensembl chr17:23,894,419...23,896,442

G

tumor necrosis factor receptor superfamily, member 1a

affects expression

nickel sulfate affects the expression of TNFRSF1A mRNA

NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447

G

tumor necrosis factor receptor superfamily, member 1b

increases expression

nickel sulfate results in increased expression of TNFRSF1B mRNA

NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440

G

tumor necrosis factor receptor superfamily, member 25

increases expression

nickel sulfate results in increased expression of TNFRSF25 mRNA

NCBI chr 4:152,199,985...152,204,568
Ensembl chr 4:152,200,391...152,204,576

G

tumor necrosis factor (ligand) superfamily, member 10

decreases expression

nickel sulfate results in decreased expression of TNFSF10 mRNA

NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576

G

tumor necrosis factor (ligand) superfamily, member 9

increases expression

nickel sulfate results in increased expression of TNFSF9 mRNA

NCBI chr17:57,412,113...57,414,757
Ensembl chr17:57,412,325...57,414,757

G

TRAF2 and NCK interacting kinase

decreases expression

nickel sulfate results in decreased expression of TNIK mRNA

NCBI chr 3:28,317,362...28,724,734
Ensembl chr 3:28,317,363...28,730,007

G

troponin T3, skeletal, fast

increases expression

nickel sulfate results in increased expression of TNNT3 mRNA

NCBI chr 7:142,052,530...142,069,746
Ensembl chr 7:142,052,573...142,069,746

G

tensin 1

decreases expression

nickel sulfate results in decreased expression of TNS1 mRNA

NCBI chr 1:73,949,391...74,163,707
Ensembl chr 1:73,949,390...74,163,608

G

transducer of ErbB-2.1

increases expression

nickel sulfate results in increased expression of TOB1 mRNA

NCBI chr11:94,100,668...94,106,321
Ensembl chr11:94,102,280...94,106,321

G

TOG array regulator of axonemal microtubules 1

decreases expression

nickel sulfate results in decreased expression of TOGARAM1 mRNA

NCBI chr12:65,012,350...65,069,347
Ensembl chr12:65,012,578...65,069,347

G

target of myb1 trafficking protein

increases expression

nickel sulfate results in increased expression of TOM1 mRNA

NCBI chr 8:75,760,326...75,796,749
Ensembl chr 8:75,760,333...75,796,749

G

translocase of outer mitochondrial membrane 34

increases expression

nickel sulfate results in increased expression of TOMM34 mRNA

NCBI chr 2:163,895,458...163,913,168
Ensembl chr 2:163,895,460...163,913,089

G

thymocyte selection-associated high mobility group box

decreases expression
increases expression

nickel sulfate results in decreased expression of TOX mRNA
nickel sulfate results in increased expression of TOX mRNA

PMID:16780908 PMID:22714537

NCBI chr 4:6,686,353...6,991,557
Ensembl chr 4:6,686,353...6,991,557

G

trophoblast glycoprotein

increases expression

nickel sulfate results in increased expression of TPBG mRNA

NCBI chr 9:85,724,433...85,729,110
Ensembl chr 9:85,724,433...85,729,093

G

tumor protein D52

increases expression

nickel sulfate results in increased expression of TPD52 mRNA

PMID:16780908 PMID:22714537

NCBI chr 3:8,991,590...9,069,824
Ensembl chr 3:8,990,653...9,069,783

G

TNF receptor-associated factor 1

increases expression

nickel sulfate results in increased expression of TRAF1 mRNA

NCBI chr 2:34,831,762...34,851,784
Ensembl chr 2:34,831,762...34,851,784

G

trafficking protein particle complex 2L

increases expression

nickel sulfate results in increased expression of TRAPPC2L mRNA

NCBI chr 8:123,338,365...123,342,330
Ensembl chr 8:123,338,379...123,343,399

G

tripartite motif-containing 16

increases expression

nickel sulfate results in increased expression of TRIM16 mRNA

NCBI chr11:62,711,034...62,733,774
Ensembl chr11:62,711,057...62,741,634

G

tripartite motif-containing 26

increases expression

nickel sulfate results in increased expression of TRIM26 mRNA

NCBI chr17:37,148,016...37,170,290
Ensembl chr17:37,148,026...37,170,290

G

tripartite motif-containing 29

increases expression

nickel sulfate results in increased expression of TRIM29 mRNA

NCBI chr 9:43,222,012...43,247,422
Ensembl chr 9:43,222,145...43,247,412

G

tripartite motif-containing 30A

decreases expression

nickel sulfate results in decreased expression of TRIM22 mRNA

NCBI chr 7:104,058,232...104,114,400
Ensembl chr 7:104,058,232...104,114,400

G

tripartite motif-containing 32

decreases expression

nickel sulfate results in decreased expression of TRIM32 mRNA

NCBI chr 4:65,523,223...65,534,477
Ensembl chr 4:65,523,223...65,534,475

G

tripartite motif-containing 33

decreases expression

nickel sulfate results in decreased expression of TRIM33 mRNA

NCBI chr 3:103,186,609...103,266,086
Ensembl chr 3:103,186,609...103,266,091

G

tripartite motif-containing 38

decreases expression
increases expression

nickel sulfate results in decreased expression of TRIM38 mRNA
nickel sulfate results in increased expression of TRIM38 mRNA

PMID:18651567 PMID:22714537

NCBI chr13:23,962,483...23,975,721
Ensembl chr13:23,953,896...23,975,511

G

tripartite motif-containing 62

increases expression

nickel sulfate results in increased expression of TRIM62 mRNA

NCBI chr 4:128,777,837...128,805,119
Ensembl chr 4:128,777,373...128,805,121

G

thyroid hormone receptor interactor 10

increases expression

nickel sulfate results in increased expression of TRIP10 mRNA

NCBI chr17:57,540,227...57,570,712
Ensembl chr17:57,556,455...57,570,665

G

tRNA methyltransferase 6

decreases expression

nickel sulfate results in decreased expression of TRMT6 mRNA

NCBI chr 2:132,646,127...132,658,127
Ensembl chr 2:132,646,127...132,657,975

G

tRNA nucleotidyl transferase, CCA-adding, 1

decreases expression

nickel sulfate results in decreased expression of TRNT1 mRNA

NCBI chr 6:106,746,099...106,759,435
Ensembl chr 6:106,746,081...106,759,435

G

trophinin

increases expression

nickel sulfate results in increased expression of TRO mRNA

NCBI chr X:149,427,706...149,440,579
Ensembl chr X:149,428,300...149,440,579

G

transformation related protein 53

multiple interactions
increases expression

nickel sulfate inhibits the reaction [Potassium Dichromate results in increased phosphorylation of TP53 protein]
nickel sulfate results in increased expression of TP53 protein

PMID:20493934 PMID:21776270 PMID:23568779

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

TSC22 domain family, member 3

decreases expression

nickel sulfate results in decreased expression of TSC22D3 mRNA

NCBI chr X:139,440,277...139,501,257
Ensembl chr X:139,440,277...139,501,408

G

tetraspanin 15

increases expression

nickel sulfate results in increased expression of TSPAN15 mRNA

NCBI chr10:62,021,175...62,067,055
Ensembl chr10:62,021,175...62,067,030

G

tetraspanin 17

increases expression

nickel sulfate results in increased expression of TSPAN17 mRNA

NCBI chr13:54,936,915...54,944,588
Ensembl chr13:54,937,190...54,944,589

G

tetraspanin 2

decreases expression

nickel sulfate results in decreased expression of TSPAN2 mRNA

NCBI chr 3:102,642,086...102,679,626
Ensembl chr 3:102,641,845...102,708,829

G

tetraspanin 33

increases expression

nickel sulfate results in increased expression of TSPAN33 mRNA

NCBI chr 6:29,694,213...29,718,557
Ensembl chr 6:29,694,221...29,718,558

G

tetraspanin 7

decreases expression

nickel sulfate results in decreased expression of TSPAN7 mRNA

NCBI chr X:10,351,355...10,462,843
Ensembl chr X:10,351,397...10,462,844

G

tetratricopeptide repeat domain 13

decreases expression

nickel sulfate results in decreased expression of TTC13 mRNA

NCBI chr 8:125,398,066...125,448,748
Ensembl chr 8:125,398,071...125,448,722

G

tubulin tyrosine ligase-like family, member 7

decreases expression

nickel sulfate results in decreased expression of TTLL7 mRNA

NCBI chr 3:146,557,312...146,690,156
Ensembl chr 3:146,558,122...146,689,764

G

tocopherol (alpha) transfer protein

decreases expression

nickel sulfate results in decreased expression of TTPA mRNA

NCBI chr 4:20,007,889...20,030,823
Ensembl chr 4:20,007,938...20,030,785

G

tweety family member 3

increases expression

nickel sulfate results in increased expression of TTYH3 mRNA

NCBI chr 5:140,606,332...140,634,826
Ensembl chr 5:140,606,333...140,634,786

G

thioredoxin 2

increases expression

nickel sulfate results in increased expression of TXN2 mRNA

NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206

G

thioredoxin interacting protein

decreases expression

nickel sulfate results in decreased expression of TXNIP mRNA

NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199

G

thioredoxin reductase 1

affects expression
increases expression

nickel sulfate affects the expression of TXNRD1 mRNA
nickel sulfate results in increased expression of TXNRD1 mRNA

PMID:12718980 PMID:17374397 PMID:20566472

NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546

G

thioredoxin reductase 2

increases expression

nickel sulfate results in increased expression of TXNRD2 mRNA

NCBI chr16:18,245,167...18,297,823
Ensembl chr16:18,245,134...18,297,823

G

thymidine phosphorylase

multiple interactions
decreases expression

[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in decreased expression of TYMP mRNA
nickel sulfate results in decreased expression of TYMP mRNA

NCBI chr15:89,255,834...89,261,282
Ensembl chr15:89,256,134...89,261,242

G

TYRO3 protein tyrosine kinase 3

decreases expression

nickel sulfate results in decreased expression of TYRO3 mRNA

NCBI chr 2:119,628,123...119,648,585
Ensembl chr 2:119,628,214...119,648,585

G

tyrosinase-related protein 1

increases expression

nickel sulfate results in increased expression of TYRP1 mRNA

NCBI chr 4:80,752,360...80,769,973
Ensembl chr 4:80,752,360...80,769,956

G

ubiquitin D

increases expression

nickel sulfate results in increased expression of UBD mRNA

NCBI chr17:37,504,783...37,506,992
Ensembl chr17:37,504,783...37,506,986

G

ubiquitin-conjugating enzyme E2E 2

decreases expression

nickel sulfate results in decreased expression of UBE2E2 mRNA

NCBI chr14:3,575,429...3,896,133
Ensembl chr14:3,575,429...3,896,121

G

ubiquitin-conjugating enzyme E2M

increases expression

nickel sulfate results in increased expression of UBE2M mRNA

NCBI chr 7:12,769,047...12,772,202
Ensembl chr 7:12,769,047...12,772,202

G

ubiquitin-conjugating enzyme E2S

increases expression

nickel sulfate results in increased expression of UBE2S mRNA

NCBI chr 7:4,811,013...4,815,339
Ensembl chr 7:4,797,545...4,815,589

G

ubiquitin-like 3

decreases expression

nickel sulfate results in decreased expression of UBL3 mRNA

NCBI chr 5:148,441,441...148,489,689
Ensembl chr 5:148,441,445...148,489,599

G

uncoupling protein 1 (mitochondrial, proton carrier)

multiple interactions

[nickel sulfate co-treated with Particulate Matter] results in decreased expression of UCP1 mRNA; [nickel sulfate co-treated with Particulate Matter] results in decreased expression of UCP1 protein

NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081

G

UDP-glucose glycoprotein glucosyltransferase 2

decreases expression

nickel sulfate results in decreased expression of UGGT2 mRNA

NCBI chr14:119,219,177...119,337,208
Ensembl chr14:119,222,451...119,336,842

G

UDP glucuronosyltransferase 1 family, polypeptide A6B

increases expression

nickel sulfate results in increased expression of UGT1A6 mRNA

NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725

G

unc-51 like kinase 2

increases expression

nickel sulfate results in increased expression of ULK2 mRNA

NCBI chr11:61,666,424...61,750,754
Ensembl chr11:61,666,475...61,745,899

G

uridine phosphorylase 1

increases expression

nickel sulfate results in increased expression of UPP1 mRNA

NCBI chr11:9,068,008...9,086,170
Ensembl chr11:9,068,103...9,086,170

G

ubiquitin specific peptidase 13 (isopeptidase T-3)

decreases expression

nickel sulfate results in decreased expression of USP13 mRNA

NCBI chr 3:32,870,432...32,992,224
Ensembl chr 3:32,871,695...32,992,220

G

ubiquitin specific peptidase 18

increases expression

nickel sulfate results in increased expression of USP18 mRNA

NCBI chr 6:121,222,865...121,247,876
Ensembl chr 6:121,222,865...121,247,876

G

ubiquitin specific peptidase 2

decreases expression

nickel sulfate results in decreased expression of USP2 mRNA

NCBI chr 9:43,978,318...44,006,924
Ensembl chr 9:43,978,318...44,006,924

G

ubiquitin specific peptidase 28

multiple interactions
decreases expression

[HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in decreased expression of USP28 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [nickel sulfate results in decreased expression of USP28 protein]; USP28 protein inhibits the reaction [nickel sulfate results in increased degradation of MYC protein]

NCBI chr 9:48,896,577...48,953,817
Ensembl chr 9:48,896,675...48,953,817

G

ubiquitin specific peptidase 9, X chromosome

decreases expression

nickel sulfate results in decreased expression of USP9X mRNA

NCBI chr X:12,937,221...13,039,567
Ensembl chr X:12,937,737...13,039,567

G

vesicle-associated membrane protein 1

increases expression

nickel sulfate results in increased expression of VAMP1 mRNA

NCBI chr 6:125,192,544...125,199,269
Ensembl chr 6:125,192,514...125,222,927

G

vesicle-associated membrane protein 5

increases expression

nickel sulfate results in increased expression of VAMP5 mRNA

NCBI chr 6:72,345,032...72,357,451
Ensembl chr 6:72,345,777...72,357,451

G

VANGL planar cell polarity 2

decreases expression

nickel sulfate results in decreased expression of VANGL2 mRNA

NCBI chr 1:171,828,527...171,856,532
Ensembl chr 1:171,828,527...171,856,011

G

vav 2 oncogene

decreases expression
increases expression

nickel sulfate results in decreased expression of VAV2 mRNA
nickel sulfate results in increased expression of VAV2 mRNA

NCBI chr 2:27,152,116...27,317,620
Ensembl chr 2:27,152,116...27,317,045

G

von Hippel-Lindau binding protein 1

decreases expression

nickel sulfate results in decreased expression of VBP1 mRNA

NCBI chr X:74,557,903...74,578,552
Ensembl chr X:74,557,905...74,578,548

G

versican

increases expression
decreases expression

nickel sulfate results in increased expression of VCAN mRNA
nickel sulfate results in decreased expression of VCAN mRNA

PMID:16166746 PMID:22714537

NCBI chr13:89,803,429...89,891,146
Ensembl chr13:89,803,431...89,890,628

G

vitamin D (1,25-dihydroxyvitamin D3) receptor

increases expression

nickel sulfate results in increased expression of VDR mRNA

PMID:17374397 PMID:22714537

NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511

G

vascular endothelial growth factor A

multiple interactions
increases expression
increases secretion

[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of VEGFA mRNA; [nickel sulfate co-treated with Dinoprostone] results in increased secretion of VEGFA protein; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of VEGFA protein]; macrophage stimulatory lipopeptide 2 promotes the reaction [nickel sulfate results in increased secretion of VEGFA protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of VEGFA protein]
nickel sulfate results in increased expression of VEGFA mRNA

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

vascular endothelial growth factor D

increases expression

nickel sulfate results in increased expression of VEGFD mRNA

NCBI chr X:163,156,282...163,185,643
Ensembl chr X:163,156,374...163,185,646

G

vitrin

increases expression

nickel sulfate results in increased expression of VIT mRNA

NCBI chr17:78,815,480...78,934,838
Ensembl chr17:78,815,493...78,934,837

G

very low density lipoprotein receptor

decreases expression

nickel sulfate results in decreased expression of VLDLR mRNA

NCBI chr19:27,190,070...27,231,631
Ensembl chr19:27,193,884...27,231,631

G

vitronectin

decreases expression

nickel sulfate results in decreased expression of VTN mRNA

NCBI chr11:78,389,946...78,393,151
Ensembl chr11:78,389,917...78,393,150

G

von Willebrand factor A domain containing 3B

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of VWA3B mRNA

NCBI chr 1:37,068,372...37,226,689
Ensembl chr 1:37,065,677...37,226,694

G

WAS/WASL interacting protein family, member 1

increases expression

nickel sulfate results in increased expression of WIPF1 mRNA

NCBI chr 2:73,259,954...73,359,831
Ensembl chr 2:73,259,954...73,360,078

G

WD repeat domain, phosphoinositide interacting 1

increases expression

nickel sulfate results in increased expression of WIPI1 mRNA

NCBI chr11:109,464,347...109,502,215
Ensembl chr11:109,464,157...109,502,793

G

WNK lysine deficient protein kinase 4

increases expression

nickel sulfate results in increased expression of WNK4 mRNA

NCBI chr11:101,151,363...101,168,235
Ensembl chr11:101,151,393...101,168,235

G

wingless-type MMTV integration site family, member 4

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of WNT4 mRNA

NCBI chr 4:137,004,946...137,026,812
Ensembl chr 4:137,004,800...137,027,037

G

wingless-type MMTV integration site family, member 5A

increases expression

nickel sulfate results in increased expression of WNT5A mRNA

NCBI chr14:28,224,962...28,249,405
Ensembl chr14:28,226,707...28,249,405

G

WT1 associating protein

decreases expression

nickel sulfate results in decreased expression of WTAP mRNA

NCBI chr17:13,185,686...13,211,430
Ensembl chr17:13,185,683...13,213,056

G

WW, C2 and coiled-coil domain containing 1

decreases expression

nickel sulfate results in decreased expression of WWC1 mRNA

NCBI chr11:35,729,226...35,871,354
Ensembl chr11:35,729,227...35,871,354

G

XIAP associated factor 1

increases expression

nickel sulfate results in increased expression of XAF1 mRNA

NCBI chr11:72,192,229...72,204,560
Ensembl chr11:72,192,455...72,204,559

G

5'-3' exoribonuclease 2

decreases expression

nickel sulfate results in decreased expression of XRN2 mRNA

NCBI chr 2:146,854,672...146,919,922
Ensembl chr 2:146,854,916...146,919,920

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

increases expression

nickel sulfate results in increased expression of YWHAE mRNA

NCBI chr11:75,620,121...75,656,667
Ensembl chr11:75,623,695...75,656,671

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide

increases expression

nickel sulfate results in increased expression of YWHAH mRNA

NCBI chr 5:33,176,160...33,185,310
Ensembl chr 5:33,176,160...33,185,310

G

zinc finger and BTB domain containing 10

increases expression

nickel sulfate results in increased expression of ZBTB10 mRNA

NCBI chr 3:9,315,627...9,350,393
Ensembl chr 3:9,315,662...9,350,393

G

zinc finger and BTB domain containing 16

increases expression

nickel sulfate results in increased expression of ZBTB16 mRNA

NCBI chr 9:48,563,097...48,747,525
Ensembl chr 9:48,565,597...48,747,522

G

zinc finger and BTB domain containing 17

decreases expression

nickel sulfate results in decreased expression of ZBTB17 mRNA

NCBI chr 4:141,171,984...141,195,248
Ensembl chr 4:141,171,965...141,195,241

G

zinc finger CCCH type containing 13

decreases expression

nickel sulfate results in decreased expression of ZC3H13 mRNA

NCBI chr14:75,521,746...75,581,873
Ensembl chr14:75,521,813...75,581,866

G

zinc finger CCCH-type containing 18

increases expression

nickel sulfate results in increased expression of ZC3H18 mRNA

NCBI chr 8:123,103,298...123,144,104
Ensembl chr 8:123,103,348...123,144,099

G

zinc finger CCCH type, antiviral 1

decreases expression

nickel sulfate results in decreased expression of ZC3HAV1 mRNA

NCBI chr 6:38,282,221...38,332,859
Ensembl chr 6:38,282,221...38,331,538

G

zinc finger, C4H2 domain containing

decreases expression

nickel sulfate results in decreased expression of ZC4H2 mRNA

NCBI chr X:94,682,793...94,702,115
Ensembl chr X:94,682,799...94,702,115

G

zinc finger, CCHC domain containing 14

increases expression

nickel sulfate results in increased expression of ZCCHC14 mRNA

NCBI chr 8:122,325,442...122,379,662
Ensembl chr 8:122,325,442...122,379,640

G

zinc finger, DHHC domain containing 18

increases expression

nickel sulfate results in increased expression of ZDHHC18 mRNA

NCBI chr 4:133,331,969...133,360,801
Ensembl chr 4:133,332,610...133,377,465

G

zinc finger, DHHC domain containing 21

decreases expression

nickel sulfate results in decreased expression of ZDHHC21 mRNA

NCBI chr 4:82,716,975...82,778,892
Ensembl chr 4:82,716,975...82,778,195

G

zinc finger, DHHC domain containing 3

decreases expression

nickel sulfate results in decreased expression of ZDHHC3 mRNA

NCBI chr 9:122,895,224...122,942,269
Ensembl chr 9:122,895,225...122,942,270

G

zinc finger E-box binding homeobox 1

increases expression
decreases expression

nickel sulfate results in increased expression of ZEB1 mRNA
nickel sulfate results in decreased expression of ZEB1 mRNA

PMID:18651567 PMID:22714537

NCBI chr18:5,591,330...5,775,468
Ensembl chr18:5,591,860...5,775,467

G

zinc finger homeodomain 4

decreases expression

nickel sulfate results in decreased expression of ZFHX4 mRNA

NCBI chr 3:5,276,268...5,480,921
Ensembl chr 3:5,283,586...5,480,917

G

zinc finger protein 146

decreases expression

nickel sulfate results in decreased expression of ZNF146 mRNA

NCBI chr 7:29,859,912...29,869,225
Ensembl chr 7:29,860,694...29,869,175

G

zinc finger protein 184 (Kruppel-like)

increases expression

nickel sulfate results in increased expression of ZNF184 mRNA

NCBI chr13:22,129,223...22,144,961
Ensembl chr13:22,129,264...22,144,949

G

zinc finger protein 239

decreases expression

nickel sulfate results in decreased expression of ZNF239 mRNA

NCBI chr 6:117,838,907...117,849,727
Ensembl chr 6:117,839,061...117,850,252

G

zinc finger protein 26

increases expression

nickel sulfate results in increased expression of ZNF778 mRNA

NCBI chr 9:20,338,457...20,371,465
Ensembl chr 9:20,339,745...20,371,458

G

zinc finger protein 27

decreases expression

nickel sulfate results in decreased expression of ZNF585B mRNA

NCBI chr 7:29,592,762...29,605,976
Ensembl chr 7:29,592,758...29,605,997

G

zinc finger protein 280B

increases expression

nickel sulfate results in increased expression of ZNF280B mRNA

NCBI chr10:75,868,235...75,878,804
Ensembl chr10:75,868,484...75,879,068

G

zinc finger protein 287

decreases expression

nickel sulfate results in decreased expression of ZNF287 mRNA

NCBI chr11:62,583,270...62,622,749
Ensembl chr11:62,591,182...62,622,731

G

zinc finger protein 334

decreases expression

nickel sulfate results in decreased expression of ZNF334 mRNA

NCBI chr 2:165,216,184...165,230,234
Ensembl chr 2:165,216,184...165,230,179

G

zinc finger protein 36, C3H type-like 1

decreases expression

nickel sulfate results in decreased expression of ZFP36L1 mRNA

PMID:16780908 PMID:17374397

NCBI chr12:80,154,534...80,159,787
Ensembl chr12:80,154,528...80,159,787

G

zinc finger protein 36, C3H type-like 2

increases expression

nickel sulfate results in increased expression of ZFP36L2 mRNA

NCBI chr17:84,491,352...84,495,375
Ensembl chr17:84,491,359...84,495,375

G

zinc finger protein 382

decreases expression

nickel sulfate results in decreased expression of ZNF382 mRNA

NCBI chr 7:29,821,255...29,840,180
Ensembl chr 7:29,821,367...29,834,375

G

zinc finger protein 385A

increases expression

nickel sulfate results in increased expression of ZNF385A mRNA

NCBI chr15:103,222,322...103,248,537
Ensembl chr15:103,222,322...103,248,520

G

zinc finger protein 422

decreases expression

nickel sulfate results in decreased expression of ZNF22 mRNA

NCBI chr 6:116,600,977...116,605,960
Ensembl chr 6:116,600,977...116,605,960

G

zinc finger protein 518A

decreases expression

nickel sulfate results in decreased expression of ZNF518A mRNA

NCBI chr19:40,882,472...40,906,391
Ensembl chr19:40,883,149...40,906,391

G

zinc finger protein 518B

decreases expression

nickel sulfate results in decreased expression of ZNF518B mRNA

NCBI chr 5:38,825,828...38,842,120
Ensembl chr 5:38,825,827...38,842,169

G

zinc finger protein 608

decreases expression

nickel sulfate results in decreased expression of ZNF608 mRNA

NCBI chr18:55,021,117...55,125,690
Ensembl chr18:55,021,120...55,125,627

G

zinc finger protein 65

increases expression

nickel sulfate results in increased expression of ZNF679 mRNA

NCBI chr13:67,853,428...67,877,238
Ensembl chr13:67,853,428...67,877,292

G

zinc finger protein 660

decreases expression

nickel sulfate results in decreased expression of ZNF660 mRNA

NCBI chr 9:122,732,313...122,743,223
Ensembl chr 9:122,732,062...122,743,219

G

zinc finger protein 709

increases expression

nickel sulfate results in increased expression of ZNF443 mRNA

NCBI chr 8:72,635,912...72,646,409
Ensembl chr 8:72,635,863...72,649,571

G

zinc finger protein 729a

increases expression

nickel sulfate results in increased expression of ZNF43 mRNA

NCBI chr13:67,760,879...67,785,925
Ensembl chr13:67,760,882...67,785,910

G

zinc finger protein 953

increases expression

nickel sulfate results in increased expression of ZNF506 mRNA

NCBI chr13:67,487,373...67,508,691
Ensembl chr13:67,487,370...67,508,724

G

zinc finger protein 961

decreases expression

nickel sulfate results in decreased expression of ZNF844 mRNA

NCBI chr 8:72,704,910...72,724,177
Ensembl chr 8:72,704,882...72,747,636

G

zinc finger, FYVE domain containing 26

decreases expression

nickel sulfate results in decreased expression of ZFYVE26 mRNA

PMID:16780908 PMID:17374397

NCBI chr12:79,279,120...79,343,102
Ensembl chr12:79,279,120...79,343,078

G

zinc finger, FYVE domain containing 9

decreases expression

nickel sulfate results in decreased expression of ZFYVE9 mRNA

NCBI chr 4:108,494,663...108,642,514
Ensembl chr 4:108,494,663...108,637,995

G

zinc finger protein of the cerebellum 2

increases expression

nickel sulfate results in increased expression of ZIC2 mRNA

NCBI chr14:122,712,796...122,717,740
Ensembl chr14:122,712,847...122,717,264

G

zinc finger, MYM-type 2

decreases expression

nickel sulfate results in decreased expression of ZMYM2 mRNA

NCBI chr14:57,123,986...57,199,815
Ensembl chr14:57,124,110...57,200,158

G

zinc finger, MYM-type 3

decreases expression
multiple interactions

nickel sulfate results in decreased expression of ZMYM3 mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of ZMYM3 mRNA

PMID:17374397 PMID:31734292

NCBI chr X:100,447,990...100,464,986
Ensembl chr X:100,447,990...100,464,455

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22277
role	22259
biological role	22258
aetiopathogenetic role	21290
allergen	18793
nickel sulfate	1592
nickel sulfate heptahydrate	0
nickel sulfate hexahydrate	0
Path 2
Term	Annotations
CHEBI ontology	22277
subatomic particle	22270
composite particle	22270
hadron	22270
baryon	22270
nucleon	22270
atomic nucleus	22270
atom	22270
main group element atom	22147
p-block element atom	22147
chalcogen	21476
oxygen atom	21455
oxygen molecular entity	21455
hydroxides	20818
oxoacid	20142
chalcogen oxoacid	14395
sulfur oxoacid	14181
sulfuric acid	8525
sulfuric acid derivative	8525
sulfates	8520
sulfate salt	7162
inorganic sulfate salt	7106
metal sulfate	7095
nickel sulfate	1592
nickel sulfate heptahydrate	0
nickel sulfate hexahydrate	0

paths to the root