Annotation (Toggle Detail/Summary View) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:2887 | 6480464 | Ethinyl Estradiol results in decreased expression of IL15 mRNA | CTD | PMID:17351261 | 17beta-estradiol | affects expression | ISO | RGD:737535 | 6480464 | Estradiol affects the expression of IL15 mRNA | CTD | PMID:14699072 | 17beta-estradiol | decreases expression | ISO | RGD:737535 | 6480464 | Estradiol results in decreased expression of IL15 mRNA | CTD | PMID:23019147 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of IL15 mRNA | CTD | PMID:12167310 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of IL15 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:2887 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of IL15 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:2887 | 6480464 | AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IL15 mRNA] | CTD | PMID:21215274 | 2,6-di-tert-butyl-4-methylphenol | affects expression | ISO | RGD:2887 | 6480464 | Butylated Hydroxytoluene affects the expression of IL15 mRNA | CTD | PMID:18539377 | 2,6-dinitrotoluene | affects expression | ISO | RGD:2887 | 6480464 | 2,6-dinitrotoluene affects the expression of IL15 mRNA | CTD | PMID:21346803 | 4-(ethoxymethylene)-2-phenyloxazol-5-one | increases expression | EXP | | 6480464 | Oxazolone results in increased expression of IL15 mRNA | CTD | PMID:11379042 | aflatoxin B1 | affects expression | ISO | RGD:737535 | 6480464 | Aflatoxin B1 affects the expression of IL15 protein | CTD | PMID:20106945 | all-trans-retinoic acid | decreases expression | ISO | RGD:2887 | 6480464 | Tretinoin results in decreased expression of IL15 mRNA | CTD | PMID:20488242 | ammonium chloride | affects expression | ISO | RGD:2887 | 6480464 | Ammonium Chloride affects the expression of IL15 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of IL15 mRNA | CTD | PMID:22228805 | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of IL15 mRNA | CTD | PMID:21151649 | copper atom | multiple interactions | ISO | RGD:737535 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of IL15 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RGD:737535 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of IL15 mRNA | CTD | PMID:20971185 | corticosterone | increases expression | ISO | RGD:2887 | 6480464 | Corticosterone results in increased expression of IL15 mRNA | CTD | PMID:15755911 | cyclosporin A | increases expression | ISO | RGD:737535 | 6480464 | Cyclosporine results in increased expression of IL15 mRNA | CTD | PMID:20106945 | D-penicillamine | increases expression | ISO | RGD:2887 | 6480464 | Penicillamine results in increased expression of IL15 mRNA | CTD | PMID:19575532 | dexamethasone | increases expression | ISO | RGD:737535 | 6480464 | Dexamethasone results in increased expression of IL15 mRNA | CTD | PMID:16144937 | dexamethasone | increases expression | EXP | | 6480464 | Dexamethasone results in increased expression of IL15 mRNA | CTD | PMID:21041162 | dexamethasone | decreases expression | ISO | RGD:2887 | 6480464 | Dexamethasone results in decreased expression of IL15 mRNA | CTD | PMID:14618091 | dextran sulfate | increases response to substance | EXP | | 6480464 | IL15 protein results in increased susceptibility to Dextran Sulfate | CTD | PMID:16162679 | dextran sulfate | multiple interactions | ISO | RGD:2887 | 6480464 | Oligosaccharides inhibits the reaction [Dextran Sulfate results in decreased expression of IL15 mRNA] | CTD | PMID:16375993 | dextran sulfate | decreases expression | ISO | RGD:2887 | 6480464 | Dextran Sulfate results in decreased expression of IL15 mRNA | CTD | PMID:16375993 | diarsenic trioxide | decreases expression | ISO | RGD:737535 | 6480464 | arsenic trioxide results in decreased expression of IL15 mRNA | CTD | PMID:20458559 | diarsenic trioxide | increases expression | ISO | RGD:737535 | 6480464 | arsenic trioxide results in increased expression of IL15 mRNA | CTD | PMID:22521957 | divanadium pentaoxide | decreases expression | ISO | RGD:737535 | 6480464 | vanadium pentoxide results in decreased expression of IL15 mRNA | CTD | PMID:17459161 | emodin | increases expression | EXP | | 6480464 | Emodin results in increased expression of IL15 mRNA | CTD | PMID:15612046 | formaldehyde | increases expression | EXP | | 6480464 | Formaldehyde results in increased expression of IL15 mRNA | CTD | PMID:12161283 | genistein | decreases expression | ISO | RGD:737535 | 6480464 | Genistein results in decreased expression of IL15 mRNA | CTD | PMID:20816778 | hexachlorobenzene | decreases expression | ISO | RGD:2887 | 6480464 | Hexachlorobenzene results in decreased expression of IL15 mRNA | CTD | PMID:15159207 | m-xylene | decreases expression | ISO | RGD:2887 | 6480464 | 3-xylene results in decreased expression of IL15 mRNA | CTD | PMID:12815608 | muramyl dipeptide | multiple interactions | ISO | RGD:737535 | 6480464 | [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL15 mRNA | CTD | PMID:16299289 | mycophenolic acid | increases expression | EXP | | 6480464 | Mycophenolic Acid results in increased expression of IL15 mRNA | CTD | PMID:19818335 | nickel dichloride | multiple interactions | ISO | RGD:737535 | 6480464 | [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL15 protein | CTD | PMID:18437699 | nickel sulfate | affects expression | ISO | RGD:737535 | 6480464 | nickel sulfate affects the expression of IL15 mRNA | CTD | PMID:18202158 | nonanoic acid | increases expression | EXP | | 6480464 | pelargonic acid results in increased expression of IL15 mRNA | CTD | PMID:11379042 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of IL15 mRNA | CTD | PMID:17562736 | paraquat | decreases expression | ISO | RGD:2887 | 6480464 | Paraquat results in decreased expression of IL15 mRNA | CTD | PMID:17077588 | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | RGD:2887 | 6480464 | Pregnenolone Carbonitrile results in decreased expression of IL15 mRNA | CTD | PMID:19162173 | progesterone | increases expression | ISO | RGD:737535 | 6480464 | Progesterone results in increased expression of IL15 mRNA | CTD | PMID:17404688 | quinolin-8-ol | increases expression | EXP | | 6480464 | Oxyquinoline results in increased expression of IL15 mRNA | CTD | PMID:15612046 | riddelliine | increases expression | ISO | RGD:2887 | 6480464 | riddelliine results in increased expression of IL15 mRNA | CTD | PMID:18047727 | sterigmatocystin | increases expression | EXP | | 6480464 | Sterigmatocystin results in increased expression of IL15 mRNA | CTD | PMID:19818335 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:737535 | 6480464 | tert-Butylhydroperoxide results in decreased expression of IL15 mRNA | CTD | PMID:15336504 | tetrachloromethane | affects expression | ISO | RGD:2887 | 6480464 | Carbon Tetrachloride affects the expression of IL15 mRNA | CTD | PMID:15963342 | toluene 2,4-diisocyanate | increases expression | EXP | | 6480464 | Toluene 2,4-Diisocyanate results in increased expression of IL15 mRNA | CTD | PMID:11243917 PMID:11379042 | toluene 2,4-diisocyanate | increases expression | EXP | | 6480464 | Toluene 2,4-Diisocyanate results in increased expression of IL15 mRNA | CTD | PMID:11379042 PMID:11243917 | urethane | multiple interactions | EXP | | 6480464 | [Urethane co-treated with Freund's Adjuvant] results in increased expression of IL15 mRNA | CTD | PMID:12400877 | urethane | increases expression | EXP | | 6480464 | Urethane results in increased expression of IL15 mRNA | CTD | PMID:12400877 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Cytokine-cytokine receptor interaction |
| Herpes simplex infection | |
| HTLV-I infection | |
| Intestinal immune network for IgA production | |
| Jak-STAT signaling pathway | |
| Rheumatoid arthritis | |
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Cytokine-cytokine receptor interaction |
| Herpes simplex infection | |
| HTLV-I infection | |
| Intestinal immune network for IgA production | |
| Jak-STAT signaling pathway | |
| Rheumatoid arthritis | |
Phenotype Annotations
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McGill J, etal., J Exp Med. 2010 Mar 15;207(3):521-34. Epub 2010 Mar 8. |
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MGD and Homologene mouse data transfer |
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MGD data from the GO Consortium |
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MGD IEA |
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Miyazaki S, etal., J Immunol. 2007 Oct 15;179(8):5407-14. |
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Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
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Poon LL, etal., J Immunol. 2009 Mar 1;182(5):3063-71. |
| 34. |
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| 36. |
RGD automated import pipeline |
| 37. |
RGD automated import pipeline for gene-chemical interactions |
| 38. |
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| 39. |
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RGD Disease Portals| Il15 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Il15 (Mus musculus) |
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| IL15 (Homo sapiens) |
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| Il15 (Rattus norvegicus) |
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Position Markers| AI503618 |
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| D8Mit343 |
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| U14332 |
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| Il15 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001254747 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_008357 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AAHY01072566 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01072567 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01072568 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01072569 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB022307 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC156993 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ012587 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK085441 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK155616 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC023698 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BX523783 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466525 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CJ137432 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DQ083236 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DQ083237 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U14332 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_008357 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_032383 | |||||||||||||||||||||||||
| Peptide Label: | precursor | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001254747 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001241676 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001241676 | (Get FASTA) |
| NP_032383 | (Get FASTA) | |
| GenBank Protein | AAA75377 | (Get FASTA) |
| AAH23698 | (Get FASTA) | |
| AAZ30727 | (Get FASTA) | |
| AAZ30728 | (Get FASTA) | |
| BAA37122 | (Get FASTA) | |
| BAE33347 | (Get FASTA) | |
| CAA10069 | (Get FASTA) | |
| EDL10891 | (Get FASTA) | |
| EDL10892 | (Get FASTA) | |
| P48346 | (Get FASTA) |
Promoters| RGD ID: | 6843315 | ||||||||||
| Promoter ID: | MM_KWN:54980 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | BoneMarrow_2Hour | ||||||||||
| Transcripts: | UC009MJJ.1 | ||||||||||
| Position: |
|
| RGD ID: | 6842574 | ||||||||||
| Promoter ID: | MM_KWN:54981 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, Kidney, Liver, Lung | ||||||||||
| Transcripts: | AK020542_9530004M14RIK, ENSMUST00000034148, UC009MJL.1, UC009MJM.1 | ||||||||||
| Position: |
|
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000031712 | |
| Entrez Gene | 16168 | ENTREZGENE |
| Germonline | ENSMUSG00000031712 | |
| HomoloGene Group ID | 487 | ENTREZGENE |
| InterPro | Interleukin-15 | UniProtKB/Swiss-Prot |
| Interleukin-15_mammal | UniProtKB/Swiss-Prot | |
| Interleukin_15-like | UniProtKB/Swiss-Prot | |
| KEGG Report | mmu:16168 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:103014 | ENTREZGENE |
| Pfam | IL15 | UniProtKB/Swiss-Prot |
| PRINTS | INTLKN15MAML | UniProtKB/Swiss-Prot |
| INTRLEUKIN15 | UniProtKB/Swiss-Prot | |
| UniGene | Mm.4392 | ENTREZGENE |
| Mm.490053 | ENTREZGENE | |
| UniProt | IL15_MOUSE | UniProtKB/Swiss-Prot |
| Q1AHQ6_MOUSE | UniProtKB/TrEMBL | |
| Q1AHQ7_MOUSE | UniProtKB/TrEMBL | |
| Q3U1Z6_MOUSE | UniProtKB/TrEMBL | |
| Q9Z0G5_MOUSE | UniProtKB/TrEMBL |
| More on Il15 | |
![]() |
Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
![]() |
MGI Report |
![]() |
NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 10786 |
| Created: | 2000-05-25 |
| Species: | Mus musculus |
| Last Modified: | 2013-06-04 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




