Tmem171 (transmembrane protein 171) - Rat Genome Database

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Gene: Tmem171 (transmembrane protein 171) Mus musculus
Analyze
Symbol: Tmem171
Name: transmembrane protein 171
RGD ID: 1614025
MGI Page MGI
Description: Predicted to be located in membrane. Orthologous to human TMEM171 (transmembrane protein 171).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gm905; MGC117733
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391398,822,744 - 98,832,142 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1398,822,743 - 98,831,342 (-)EnsemblGRCm39 Ensembl
GRCm381398,686,236 - 98,695,654 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1398,686,235 - 98,694,834 (-)EnsemblGRCm38mm10GRCm38
MGSCv371399,456,193 - 99,464,786 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361399,786,395 - 99,794,988 (-)NCBIMGSCv36mm8
Celera13102,345,922 - 102,354,526 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1352.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium silicate  (EXP)
carbon nanotube  (EXP)
chromium(6+)  (ISO)
chrysene  (EXP)
CU-O LINKAGE  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (EXP)
dichloroacetic acid  (EXP)
dioxygen  (ISO)
diquat  (EXP)
ethanol  (ISO)
folic acid  (EXP)
fonofos  (ISO)
gentamycin  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
lipopolysaccharide  (ISO)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (ISO)
nitrofen  (ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (EXP)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
succimer  (EXP)
temozolomide  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:21267068   PMID:21677750  


Genomics

Comparative Map Data
Tmem171
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391398,822,744 - 98,832,142 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1398,822,743 - 98,831,342 (-)EnsemblGRCm39 Ensembl
GRCm381398,686,236 - 98,695,654 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1398,686,235 - 98,694,834 (-)EnsemblGRCm38mm10GRCm38
MGSCv371399,456,193 - 99,464,786 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361399,786,395 - 99,794,988 (-)NCBIMGSCv36mm8
Celera13102,345,922 - 102,354,526 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1352.13NCBI
TMEM171
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38573,120,575 - 73,131,809 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl573,120,569 - 73,131,809 (+)EnsemblGRCh38hg38GRCh38
GRCh37572,416,402 - 72,427,636 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36572,452,158 - 72,463,397 (+)NCBINCBI36Build 36hg18NCBI36
Celera568,311,763 - 68,323,014 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef567,622,070 - 67,633,327 (+)NCBIHuRef
CHM1_1571,849,116 - 71,860,378 (+)NCBICHM1_1
T2T-CHM13v2.0573,601,908 - 73,613,146 (+)NCBIT2T-CHM13v2.0
Tmem171
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8231,769,486 - 31,779,358 (-)NCBIGRCr8
mRatBN7.2230,035,278 - 30,045,996 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl230,035,278 - 30,045,049 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx237,093,085 - 37,106,136 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.022,313,122 - 2,326,173 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0230,003,666 - 30,013,446 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0228,791,831 - 28,802,135 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl228,791,875 - 28,801,223 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0247,889,908 - 47,900,063 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4229,301,092 - 29,310,650 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1229,221,460 - 29,231,019 (-)NCBI
Celera226,071,073 - 26,080,320 (-)NCBICelera
Cytogenetic Map2q12NCBI
Tmem171
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542527,457,185 - 27,464,513 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542527,457,245 - 27,466,484 (-)NCBIChiLan1.0ChiLan1.0
TMEM171
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2442,183,385 - 42,194,835 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1540,337,014 - 40,348,485 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0542,181,966 - 42,193,088 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1542,781,305 - 42,789,684 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl542,781,305 - 42,789,684 (-)Ensemblpanpan1.1panPan2
TMEM171
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1256,036,463 - 56,044,443 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl256,037,975 - 56,044,464 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha253,008,185 - 53,018,390 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0256,558,208 - 56,566,307 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl256,559,817 - 56,566,307 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1253,617,060 - 53,627,212 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0254,384,978 - 54,395,341 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0255,275,830 - 55,286,629 (+)NCBIUU_Cfam_GSD_1.0
Tmem171
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213187,446,269 - 187,455,734 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365493,403,222 - 3,412,348 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365493,403,250 - 3,411,897 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM171
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl282,287,158 - 82,297,856 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1282,287,211 - 82,297,855 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2283,995,709 - 84,006,354 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM171
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1467,463,098 - 67,476,538 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl467,462,987 - 67,475,326 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604916,230,129 - 16,241,665 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem171
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249052,167,045 - 2,177,234 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249052,167,147 - 2,176,964 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem171
322 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:90
Interacting mature miRNAs:93
Transcripts:ENSMUST00000064347, ENSMUST00000148950
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
1301445Listr2_mlisteriosis resistance 2 (mouse)Not determined1366744601100744746Mouse
1301593Heal8_mwound healing/regeneration 8 (mouse)Not determined1368053999102054119Mouse
14696726Kidrq3_mkidney weight, right QTL 3 (mouse)1368217066102217066Mouse
14747007Mancz11_mmandible centroid size 11 (mouse)1370111284104111284Mouse
4141266Mol3_mmodifier of LPS-response 3 (mouse)Not determined76132600112431103Mouse
12880414V125Dq10_mvitamin D active form serum level QTL 10 (mouse)1378036508112036508Mouse
10043997Bw40_mbody weight QTL 40 (mouse)Not determined1479239045113239162Mouse
10045623Heal18_mwound healing regeneration 18 (mouse)Not determined1379239045113239162Mouse
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382739968116740106Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383876060117876256Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386341617120341758Mouse
4141728Egaq4_mearly growth adjusted QTL 4 (mouse)Not determined87901985112431103Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391383692120883175Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391965303120883175Mouse
1301142Heal2_mwound healing/regeneration 2 (mouse)Not determined1393875267120883175Mouse
4142338Skmw18_mskeletal muscle weight 18 (mouse)Not determined1394528399120883175Mouse
1558763Gct9_mgranulosa cell tumorigenesis 9 (mouse)Not determined1395036824120883175Mouse
1357468Rplag_mreduced platelet aggregation (mouse)Not determined1395502130120883175Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000064347   ⟹   ENSMUSP00000070369
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1398,822,743 - 98,831,342 (-)Ensembl
GRCm38.p6 Ensembl1398,686,235 - 98,694,834 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148950   ⟹   ENSMUSP00000121382
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1398,828,822 - 98,831,276 (-)Ensembl
GRCm38.p6 Ensembl1398,692,314 - 98,694,768 (-)Ensembl
RefSeq Acc Id: NM_001025606   ⟹   NP_001020777
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391398,822,746 - 98,831,339 (-)NCBI
GRCm381398,686,238 - 98,694,831 (-)NCBI
MGSCv371399,456,193 - 99,464,786 (-)RGD
Celera13102,345,922 - 102,354,526 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001373965   ⟹   NP_001360894
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391398,822,746 - 98,831,350 (-)NCBI
GRCm381398,686,238 - 98,694,842 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011244676   ⟹   XP_011242978
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391398,822,744 - 98,832,072 (-)NCBI
GRCm381398,686,236 - 98,695,564 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011244677   ⟹   XP_011242979
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391398,822,744 - 98,832,142 (-)NCBI
GRCm381398,686,236 - 98,695,654 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011244678   ⟹   XP_011242980
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391398,830,854 - 98,832,072 (-)NCBI
GRCm381398,694,346 - 98,695,564 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001020777   ⟸   NM_001025606
- Peptide Label: isoform 2
- UniProtKB: Q4KL18 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011242979   ⟸   XM_011244677
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011242978   ⟸   XM_011244676
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011242980   ⟸   XM_011244678
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001360894   ⟸   NM_001373965
- Peptide Label: isoform 1
RefSeq Acc Id: ENSMUSP00000121382   ⟸   ENSMUST00000148950
RefSeq Acc Id: ENSMUSP00000070369   ⟸   ENSMUST00000064347

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KL18-F1-model_v2 AlphaFold Q4KL18 1-322 view protein structure

Promoters
RGD ID:8681116
Promoter ID:EPDNEW_M18589
Type:initiation region
Name:Tmem171_1
Description:Mus musculus transmembrane protein 171 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381398,694,842 - 98,694,902EPDNEW
RGD ID:6824447
Promoter ID:MM_KWN:15025
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney
Transcripts:OTTMUST00000068556,   OTTMUST00000068557
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361399,464,659 - 99,465,159 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685751 AgrOrtholog
Ensembl Genes ENSMUSG00000052485 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000064347 ENTREZGENE
  ENSMUST00000064347.8 UniProtKB/Swiss-Prot
  ENSMUST00000148950.2 UniProtKB/TrEMBL
InterPro TMEM171 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:380863 UniProtKB/Swiss-Prot
MGD MGI:2685751 ENTREZGENE
NCBI Gene 380863 ENTREZGENE
PANTHER PTHR31617 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 171 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TMEM171 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmem171 PhenoGen
UniProt D3Z2U9_MOUSE UniProtKB/TrEMBL
  Q4KL18 ENTREZGENE, UniProtKB/Swiss-Prot