Fahd2a (fumarylacetoacetate hydrolase domain containing 2A) - Rat Genome Database

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Gene: Fahd2a (fumarylacetoacetate hydrolase domain containing 2A) Mus musculus
Analyze
Symbol: Fahd2a
Name: fumarylacetoacetate hydrolase domain containing 2A
RGD ID: 1558506
MGI Page MGI
Description: Predicted to enable hydrolase activity and metal ion binding activity. Located in mitochondrion. Orthologous to several human genes including FAHD2A (fumarylacetoacetate hydrolase domain containing 2A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1500003K14Rik; B430104H02Rik; Cgi-105; Fahd2; fumarylacetoacetate hydrolase domain-containing protein 2A
RGD Orthologs
Human
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,278,135 - 127,286,491 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,278,135 - 127,286,485 (-)EnsemblGRCm39 Ensembl
GRCm382127,436,215 - 127,444,571 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,436,215 - 127,444,565 (-)EnsemblGRCm38mm10GRCm38
MGSCv372127,261,951 - 127,270,301 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362127,127,656 - 127,135,946 (-)NCBIMGSCv36mm8
Celera2128,678,251 - 128,686,589 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15774318   PMID:16141072   PMID:16141073   PMID:18614015   PMID:21677750   PMID:21873635   PMID:30973865  
PMID:32581705  


Genomics

Comparative Map Data
Fahd2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,278,135 - 127,286,491 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,278,135 - 127,286,485 (-)EnsemblGRCm39 Ensembl
GRCm382127,436,215 - 127,444,571 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,436,215 - 127,444,565 (-)EnsemblGRCm38mm10GRCm38
MGSCv372127,261,951 - 127,270,301 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362127,127,656 - 127,135,946 (-)NCBIMGSCv36mm8
Celera2128,678,251 - 128,686,589 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.01NCBI
FAHD2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38295,402,708 - 95,421,656 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl295,402,708 - 95,416,616 (+)EnsemblGRCh38hg38GRCh38
GRCh37296,068,456 - 96,082,364 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36295,432,175 - 95,442,606 (+)NCBINCBI36Build 36hg18NCBI36
Build 34295,490,321 - 95,500,753NCBI
Celera290,421,569 - 90,432,000 (+)NCBICelera
Cytogenetic Map2q11.1NCBI
HuRef290,095,394 - 90,105,821 (+)NCBIHuRef
CHM1_1296,072,763 - 96,083,194 (+)NCBICHM1_1
T2T-CHM13v2.0295,909,154 - 95,928,138 (+)NCBIT2T-CHM13v2.0
Fahd2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554703,624,462 - 3,632,949 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554703,624,462 - 3,632,949 (+)NCBIChiLan1.0ChiLan1.0
FAHD2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21232,877,620 - 32,890,484 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A32,879,283 - 32,893,235 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A103,989,665 - 104,001,885 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A96,317,574 - 96,321,008 (+)NCBIpanpan1.1PanPan1.1panPan2
Fahd2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,923,012 - 82,930,693 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936744175,882 - 183,675 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936744175,948 - 183,631 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100522130
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1345,857,494 - 45,888,353 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2348,458,590 - 48,487,135 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103241057
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114437,719 - 446,738 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14437,662 - 446,552 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023667445552 - 1,309 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101700516
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247492,138,410 - 2,152,673 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247492,138,188 - 2,152,673 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fahd2a
179 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1013
Count of miRNA genes:484
Interacting mature miRNAs:561
Transcripts:ENSMUST00000028848, ENSMUST00000123327, ENSMUST00000137366, ENSMUST00000137502, ENSMUST00000146437, ENSMUST00000146615, ENSMUST00000146757
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297123370131123532Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297123370131123532Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297210364131210364Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297210364131210364Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100824060134824269Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2100942930134943090Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2100942930134943090Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2100942930134943090Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
11041906Lmr28a_mleishmaniasis resistance 28a (mouse)2103095716129213005Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106233580140233729Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107255676141255676Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110489658144489807Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111173704145173821Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111173704145173821Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111173704145173821Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111173704145173821Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111551028145551163Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111623386145623526Mouse
1300798Actre3_mactivity response to ethanol 3 (mouse)Not determined2112024987128173821Mouse
1301415Actre4_mactivity response to ethanol 4 (mouse)Not determined2112024987128173821Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112212746146213005Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112212746146213005Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112212746146213005Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114288075132714157Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115212857149212994Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122207146142532135Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123231973148700377Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
13506763Tbvq1_mtrabecular bone volume QTL 1 (mouse)2126041920135441920Mouse

Markers in Region
RH142366  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382127,436,355 - 127,436,784UniSTSGRCm38
MGSCv372127,262,091 - 127,262,520UniSTSGRCm37
Celera2128,678,391 - 128,678,820UniSTS
Cytogenetic Map2F3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000028848   ⟹   ENSMUSP00000028848
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2127,278,135 - 127,286,470 (-)Ensembl
GRCm38.p6 Ensembl2127,436,215 - 127,444,550 (-)Ensembl
RefSeq Acc Id: ENSMUST00000123327
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2127,278,191 - 127,280,239 (-)Ensembl
GRCm38.p6 Ensembl2127,436,271 - 127,438,319 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137366
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2127,278,757 - 127,286,477 (-)Ensembl
GRCm38.p6 Ensembl2127,436,837 - 127,444,557 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137502
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2127,282,351 - 127,286,428 (-)Ensembl
GRCm38.p6 Ensembl2127,440,431 - 127,444,508 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146437
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2127,280,042 - 127,286,400 (-)Ensembl
GRCm38.p6 Ensembl2127,438,122 - 127,444,480 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146615
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2127,280,331 - 127,286,436 (-)Ensembl
GRCm38.p6 Ensembl2127,438,411 - 127,444,516 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146757
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2127,278,136 - 127,286,485 (-)Ensembl
GRCm38.p6 Ensembl2127,436,216 - 127,444,565 (-)Ensembl
RefSeq Acc Id: NM_029629   ⟹   NP_083905
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392127,278,135 - 127,286,485 (-)NCBI
GRCm382127,436,215 - 127,444,565 (-)ENTREZGENE
MGSCv372127,261,951 - 127,270,301 (-)RGD
Celera2128,678,251 - 128,686,589 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006500090   ⟹   XP_006500153
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392127,278,135 - 127,286,491 (-)NCBI
GRCm382127,436,215 - 127,444,571 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006500091   ⟹   XP_006500154
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392127,278,135 - 127,286,477 (-)NCBI
GRCm382127,436,215 - 127,444,557 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_083905   ⟸   NM_029629
- UniProtKB: Q8K0V8 (UniProtKB/Swiss-Prot),   Q3TC72 (UniProtKB/Swiss-Prot),   A0A0R4J094 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006500153   ⟸   XM_006500090
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006500154   ⟸   XM_006500091
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000028848   ⟸   ENSMUST00000028848
Protein Domains
Fumarylacetoacetase-like C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3TC72-F1-model_v2 AlphaFold Q3TC72 1-313 view protein structure

Promoters
RGD ID:6831324
Promoter ID:MM_KWN:31599
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000038204,   OTTMUST00000038205,   OTTMUST00000038207,   OTTMUST00000038208,   OTTMUST00000038209,   OTTMUST00000038210
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362127,270,061 - 127,270,561 (-)MPROMDB
RGD ID:6878648
Promoter ID:EPDNEW_M2775
Type:multiple initiation site
Name:Fahd2a_1
Description:Mus musculus fumarylacetoacetate hydrolase domain containing2A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382127,444,557 - 127,444,617EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915376 AgrOrtholog
Ensembl Genes ENSMUSG00000027371 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000028848 ENTREZGENE
  ENSMUST00000028848.4 UniProtKB/TrEMBL
Gene3D-CATH 3.90.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fumarylacetoacetase-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarylacetoacetase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:68126 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1915376 ENTREZGENE
NCBI Gene 68126 ENTREZGENE
PANTHER FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FAA_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fahd2a PhenoGen
Superfamily-SCOP SSF56529 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J094 ENTREZGENE, UniProtKB/TrEMBL
  FAHD2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8K0V8 ENTREZGENE
UniProt Secondary Q8K0V8 UniProtKB/Swiss-Prot