Gene: Ccl1 (chemokine (C-C motif) ligand 1)
Mus musculus
Symbol:
Ccl1
Name:
chemokine (C-C motif) ligand 1
Description:
ENCODES a protein that exhibits cytokine activity; INVOLVED IN chemotaxis; ASSOCIATED WITH abnormal inflammatory response; abnormal regulatory T cell physiology; ASSOCIATED WITH Granuloma, Respiratory Tract; Pulmonary Eosinophilia; Respiratory Syncytial Virus Infections; FOUND IN extracellular region (inferred); extracellular space (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; cisplatin
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
BF534335; C-C motif chemokine 1; CCR8 ligand; I-309; OTTMUSP00000000867; P500; Scya1; SIS-epsilon; small inducible cytokine A1; small-inducible cytokine A1; T-cell activation protein 3; Tca-3; TCA3
Orthologs:
Homo sapiens : CCL1
(chemokine (C-C motif) ligand 1)
HGNC
Rattus norvegicus : Ccl1
(chemokine (C-C motif) ligand 1)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 11 82,176,666 - 82,179,812 - NCBI Mouse cM Map 11 49.99 NCBI Mouse Celera Assembly 11 91,796,179 - 91,799,095 - NCBI Mouse Genome Assembly Build 37 11 81,990,168 - 81,993,314 - NCBI Mouse Genome Assembly Build 36.1 11 81,990,168 - 81,993,316 - NCBI Mouse Cytogenetic Map 11 C NCBI
Model
Gene-Chemical Interaction Annotations
2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1353511 6480464 KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCL1 mRNA] CTD PMID:18089838 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1353511 6480464 Tetrachlorodibenzodioxin results in increased expression of CCL1 mRNA CTD PMID:16679317 PMID:18089838 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1353511 6480464 Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to RELB protein] which binds to CCL1 promoter]; more ... CTD PMID:17900530 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1353511 6480464 3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCL1 mRNA]; more ... CTD PMID:16679317 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of CCL1 mRNA CTD PMID:16120747 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1353511 6480464 Tetrachlorodibenzodioxin results in increased expression of CCL1 protein CTD PMID:16679317 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1353511 6480464 Tetrachlorodibenzodioxin results in increased expression of CCL1 mRNA CTD PMID:18089838 PMID:16679317 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine affects expression ISO RGD:1586495 6480464 Puromycin Aminonucleoside affects the expression of CCL1 mRNA CTD PMID:10867541 all-trans-retinoic acid increases expression ISO RGD:1353511 6480464 Tretinoin results in increased expression of CCL1 protein; more ... CTD PMID:19828696 all-trans-retinoic acid multiple interactions ISO RGD:1353511 6480464 [arsenic trioxide co-treated with Tretinoin] results in increased expression of CCL1 mRNA CTD PMID:19828696 arsenic atom decreases expression ISO RGD:1353511 6480464 Arsenic results in decreased expression of CCL1 mRNA CTD PMID:19962721 arsenic atom multiple interactions ISO RGD:1353511 6480464 [Arsenic co-treated with Fluorides] results in decreased expression of CCL1 mRNA CTD PMID:19962721 benzo[a]pyrene multiple interactions ISO RGD:1353511 6480464 2-aminoethoxydiphenyl borate inhibits the reaction [Benzo(a)pyrene results in increased expression of CCL1 mRNA]; more ... CTD PMID:16679317 benzo[a]pyrene increases expression ISO RGD:1353511 6480464 Benzo(a)pyrene results in increased expression of CCL1 mRNA CTD PMID:20064835 PMID:16679317 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CCL1 mRNA CTD PMID:16679317 benzo[a]pyrene increases expression ISO RGD:1353511 6480464 Benzo(a)pyrene results in increased expression of CCL1 mRNA CTD PMID:16679317 PMID:20064835 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of CCL1 mRNA CTD PMID:15814532 clozapine decreases expression ISO RGD:1353511 6480464 Clozapine results in decreased expression of CCL1 mRNA CTD PMID:17346280 dasatinib (anhydrous) decreases expression ISO RGD:1353511 6480464 dasatinib results in decreased expression of CCL1 protein CTD PMID:17962511 diarsenic trioxide multiple interactions ISO RGD:1353511 6480464 [arsenic trioxide co-treated with Tretinoin] results in increased expression of CCL1 mRNA CTD PMID:19828696 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of CCL1 mRNA CTD PMID:20542052 nickel dichloride increases secretion ISO RGD:1353511 6480464 nickel chloride results in increased secretion of CCL1 protein CTD PMID:18437699 nickel sulfate increases expression ISO RGD:1353511 6480464 nickel sulfate results in increased expression of CCL1 mRNA CTD PMID:11145678 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1353511 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CCL1 mRNA CTD PMID:16979875 resveratrol decreases expression ISO RGD:1586495 6480464 resveratrol results in decreased expression of CCL1 protein CTD PMID:22507635 resveratrol multiple interactions ISO RGD:1353511 6480464 resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of CCL1] CTD PMID:16679317 sterigmatocystin increases expression EXP 6480464 Sterigmatocystin results in increased expression of CCL1 mRNA CTD PMID:19818335 titanium dioxide increases secretion ISO RGD:1353511 6480464 titanium dioxide results in increased secretion of CCL1 protein CTD PMID:20005940 titanium dioxide affects expression ISO RGD:1353511 6480464 titanium dioxide affects the expression of CCL1 mRNA CTD PMID:19695317 trans-resveratrol decreases expression ISO RGD:1586495 6480464 resveratrol results in decreased expression of CCL1 protein CTD PMID:22507635 trans-resveratrol multiple interactions ISO RGD:1353511 6480464 resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of CCL1] CTD PMID:16679317 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of CCL1 mRNA CTD PMID:17963808 zinc atom multiple interactions ISO RGD:1353511 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CCL1 mRNA CTD PMID:16979875 zinc(0) multiple interactions ISO RGD:1353511 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CCL1 mRNA CTD PMID:16979875
Biological Process
chemotaxis IDA 2290270 MGI:MGI:1270976|PMID:9670926 MGI MGI:MGI:1270976 PMID:9670926 immune response IEA InterPro:IPR000827|InterPro:IPR001811 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098
Cellular Component
extracellular region IEA InterPro:IPR000827|InterPro:IPR001811 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 extracellular space IEA UniProtKB-KW:KW-0202 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
Molecular Function
chemokine activity IEA InterPro:IPR000827|InterPro:IPR001811 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 cytokine activity IDA 2290270 MGI:MGI:1270976|PMID:9670926 MGI MGI:MGI:1270976 PMID:9670926 protein binding IPI UniProtKB:P56484 2290270 MGI:MGI:1270976|PMID:9670926 MGI MGI:MGI:1270976 PMID:9670926
1558963 Sphsr2_m spermatocyte heat stress resistance 2 (mouse) Not determined 11 50000867 84001087 Mouse 1301830 Ssta4_m susceptibility to Salmonella typhimurium antigens 4 (mouse) Not determined 11 50000867 84001087 Mouse 4141825 Hdlq37_m HDL QTL 37 (mouse) Not determined 11 51422759 85423006 Mouse 1357827 Hdl39_m HDL level 39 (mouse) Not determined 11 51422759 85423006 Mouse 1357794 Cinda1_m cytokine induced activation 1 (mouse) Not determined 11 51422759 85423006 Mouse 1301842 Gvhd4_m graft-versus host disease 4 (mouse) Not determined 11 52101109 86101222 Mouse 4141085 Rbcq3_m red blood cell QTL 3 (mouse) Not determined 11 52607486 86607663 Mouse 1300744 Tshp10_m tooth shape 10 (mouse) Not determined 11 52761978 86762125 Mouse 1301906 Bgeq9_m body growth early QTL 9 (mouse) Not determined 11 52761978 86762125 Mouse 1302108 Skl5_m skeletal size (tail length) 5 (mouse) Not determined 11 52761978 86762125 Mouse 1301238 Pas5_m pulmonary adenoma susceptibility 5 (mouse) Not determined 11 52761978 86762125 Mouse 1300774 Pgia7_m proteoglycan induced arthritis 7 (mouse) Not determined 11 53313264 87313413 Mouse 1558896 Motp1_m modifier of Trp53 1 (mouse) Not determined 11 53313264 87313413 Mouse 4141612 Cia40_m collagen induced arthritis 40 (mouse) Not determined 11 53988346 117993212 Mouse 4141830 Pregq1_m pregnancy QTL 1 (mouse) Not determined 11 54049428 83656328 Mouse 4142121 Tmc1m2_m Tmc1 modifier 2 (mouse) Not determined 11 56786703 114128445 Mouse 1301548 Idd4_m insulin dependent diabetes susceptibility 4 (mouse) Not determined 11 57677336 91677434 Mouse 1301182 Vmbic6_m ventral midbrain iron content 6 (mouse) Not determined 11 59777286 93777433 Mouse 4142202 Feml4_m femur length in high growth mice 4 (mouse) Not determined 11 59866991 93867100 Mouse 1301319 Dautb4_m dopamine uptake transporter binding 4 (mouse) Not determined 11 62078681 96078829 Mouse 1301956 Orch3_m autoimmune orchitis resistance 3 (mouse) Not determined 11 62736435 96736588 Mouse 1300765 Bbaa4_m B.burgdorferi-associated arthritis 4 (mouse) Not determined 11 66403911 100404032 Mouse 1301030 Bw4_m body weight QTL 4 (mouse) Not determined 11 66403911 100404032 Mouse 1300784 Prdt3_m prion disease incubation time 3 (mouse) Not determined 11 66656096 100656328 Mouse 1357766 Si5lq6_m serum IGFBP-5 level QTL 6 (mouse) Not determined 11 66656096 100656328 Mouse 1301546 Pcir2_m periosteal circumference 2 (mouse) Not determined 11 66656096 100656328 Mouse 1301833 Tbbmd5_m total body bone mineral density 5 (mouse) Not determined 11 66656096 100656328 Mouse 4141264 Qbis3_m QTL for body weight independent of sex 3 (mouse) Not determined 11 66656096 100656328 Mouse 4141767 Kwq15_m kidney weight QTL 15 (mouse) Not determined 11 66656096 100656328 Mouse 4142191 Lwq9_m liver weight QTL 9 (mouse) Not determined 11 66656096 100656328 Mouse 1300628 Lgth6_m body length 6 (mouse) Not determined 11 66656096 100656328 Mouse 1301161 Slthsr_m semilethal sex-restricted (mouse) Not determined 11 67654000 101654138 Mouse 1357580 Pltct2_m platelet count 2 (mouse) Not determined 11 69874328 103874451 Mouse 1302124 Eae7_m susceptibility to experimental allergic encephalomyelitis 7 (mouse) Not determined 11 69874328 103874451 Mouse 4141339 Nilac2_m nicotine induced locomotor activity 2 (mouse) Not determined 11 70613874 104614042 Mouse 1301681 Sle13_m systematic lupus erythematosus susceptibility 13 (mouse) Not determined 11 70613874 104614042 Mouse 1300651 Pcyts3_m plasmacytoma susceptibility 3 (mouse) Not determined 11 70613874 104614042 Mouse 1558812 Rafar_m retinoic acid induced forelimb autopod reduction (mouse) Not determined 11 70613874 104614042 Mouse 1300957 Pbd1_m peak bone density 1 (mouse) Not determined 11 71990137 105990222 Mouse 1301404 Sbmd4_m spinal bone mineral density 4 (mouse) Not determined 11 71990137 105990222 Mouse 1301078 Alcp2_m alcohol preference locus 2 (mouse) Not determined 11 72132472 84654138 Mouse 1301654 Aliq1_m acute lung injury QTL 1 (mouse) Not determined 11 72696613 106696777 Mouse 1301310 Tmevd5_m Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse) Not determined 11 72696613 106696777 Mouse 1558996 Bomd7_m bone mineral density 7 (mouse) Not determined 11 72696613 106696777 Mouse 4142348 Pstc2_m periosteal circumference 2 (mouse) Not determined 11 72789103 106789221 Mouse 1357551 Stzid_m streptozotocin induced diabetes susceptibility (mouse) Not determined 11 73114273 107114396 Mouse 1301414 Heal10_m wound healing/regeneration 10 (mouse) Not determined 11 77407671 111407810 Mouse 4141332 Azdm5_m Alzheimer's disease modifier 5 (mouse) Not determined 11 77407671 111407810 Mouse 1301535 Pas5b_m pulmonary adenoma susceptibility 5b (mouse) Not determined 11 79146953 113147090 Mouse 1301038 C10bw3_m castaneus 10 week body weight 3 (mouse) Not determined 11 79868181 113868314 Mouse 1301153 Estq3_m estradiol regulated response QTL 3 (mouse) Not determined 11 79868181 113868314 Mouse 4142145 Wg7_m weight gain in high growth mice 7 (mouse) Not determined 11 79868181 113868314 Mouse 4142072 Brwq1_m brain weight QTL 1 (mouse) Not determined 11 79868181 113868314 Mouse 1300766 Skull16_m skull morphology 16 (mouse) Not determined 11 81544969 115545124 Mouse 1301313 Pas5a_m pulmonary adenoma susceptibility 5a (mouse) Not determined 11 81544969 115545124 Mouse 1558999 Ethm4_m ethanol induced thermoregulation 4 (mouse) Not determined 11 81544969 115545124 Mouse 1300649 Crhq1_m compensatory renal hypertrophy QTL 1 (mouse) Not determined 11 81544969 115545124 Mouse