Pten (phosphatase and tensin homolog) - Rat Genome Database

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Gene: Pten (phosphatase and tensin homolog) Mus musculus
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Symbol: Pten
Name: phosphatase and tensin homolog
RGD ID: 62287
MGI Page MGI
Description: Enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and protein kinase binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of neuron projection development; and nervous system development. Acts upstream of or within several processes, including circulatory system development; negative regulation of cell population proliferation; and regulation of apoptotic process. Located in several cellular components, including Schmidt-Lanterman incisure; myelin sheath adaxonal region; and neuron projection. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; genitourinary system; and integumental system. Used to study several diseases, including Cowden syndrome (multiple); carcinoma (multiple); macrocephaly-autism syndrome; persistent fetal circulation syndrome; and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); macrocephaly-autism syndrome; nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; inositol polyphosphate 3-phosphatase; MGC183880; mitochondrial PTENalpha; MMAC; MMAC1; mutated in multiple advanced cancers 1; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; PTENbeta; PTENepsilon; RIKEN cDNA B430203M17 gene; TEP; TEP1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391932,734,977 - 32,803,560 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1932,734,897 - 32,803,560 (+)EnsemblGRCm39 Ensembl
GRCm381932,757,577 - 32,826,160 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1932,757,497 - 32,826,160 (+)EnsemblGRCm38mm10GRCm38
MGSCv371932,832,067 - 32,900,650 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361932,823,574 - 32,892,157 (+)NCBIMGSCv36mm8
Celera1933,541,182 - 33,610,051 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1928.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (IAGP)
acute megakaryocytic leukemia  (ISO)
acute myocardial infarction  (IEP,ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
angiomyolipoma  (ISO)
anisometropia  (ISO)
asthma  (ISO)
Ataxia  (IMP)
autism spectrum disorder  (IAGP,ISO)
autistic disorder  (ISO)
bacterial pneumonia  (IMP)
Bannayan-Riley-Ruvalcaba syndrome  (IAGP,ISO)
biliary atresia  (ISO)
bladder squamous cell carcinoma  (ISO)
brain disease  (IAGP)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (IDA,ISO)
Cardiovascular Abnormalities  (ISO)
cataract  (IMP)
cerebral cavernous malformation  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chlamydiaceae Infections  (IEP)
cholangiocarcinoma  (IMP,ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Hypomyelinating Neuropathy  (ISO)
Cowden syndrome  (IAGP,ISO)
Cowden syndrome 4  (ISO)
Craniofacial Abnormalities  (ISO)
developmental coordination disorder  (ISO)
Developmental Disabilities  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Ductal Carcinoma  (ISO)
endometrial adenocarcinoma  (IGI)
endometrial cancer  (IAGP)
endometrial carcinoma  (ISO)
endometrial hyperplasia  (ISO)
Endometrial Intraepithelial Neoplasia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
epilepsy  (ISO)
Epstein-Barr virus infectious disease  (ISO)
esophageal cancer  (ISO)
Experimental Mammary Neoplasms  (IAGP)
Experimental Melanoma  (ISO)
familial meningioma  (ISO)
fetal alcohol spectrum disorder  (ISO)
Follicular Thyroid Cancer  (ISO)
gastric adenocarcinoma  (ISO)
Gastrointestinal Neoplasms  (ISO)
Generalized Epilepsy  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
Helicobacter Infections  (ISO)
hemangioma  (ISO)
hemangiopericytoma  (ISO)
Hemimegalencephaly  (ISO)
hepatitis B  (IEP)
hepatocellular adenoma  (IMP,ISO)
hepatocellular carcinoma  (IAGP,IMP,ISO)
Hepatomegaly  (IMP)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
Hypertrophy  (ISO)
in situ carcinoma  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
intermediate coronary syndrome  (ISO)
intestinal pseudo-obstruction  (IAGP)
Intimal Hyperplasia  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
juvenile polyposis syndrome  (ISO)
Language Development Disorders  (ISO)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (ISO)
leukemia  (ISO)
lipoma  (ISO)
lipomatosis  (ISO)
liver cirrhosis  (IEP,ISO)
long QT syndrome  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphoma  (ISO)
Macrocephaly  (ISO)
macrocephaly-autism syndrome  (IAGP,ISO)
major depressive disorder  (ISO)
melanoma  (ISO)
meningioma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Mouth Neoplasms  (ISO)
Multiple Abnormalities  (ISO)
muscular dystrophy  (IDA)
myeloproliferative neoplasm  (ISO)
Myocardial Reperfusion Injury  (IMP,ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (IAGP,ISO)
Neoplastic Cell Transformation  (ISO)
Nerve Sheath Neoplasms  (IMP)
Nervous System Malformations  (ISO)
Neurodevelopmental Disorders  (ISO)
Noonan syndrome with multiple lentigines  (ISO)
oral squamous cell carcinoma  (ISO)
osteochondrodysplasia  (IMP)
ovarian cancer  (ISO)
Ovarian Neoplasms  (IAGP,ISO)
ovarian serous carcinoma  (ISO)
pancreatic cancer  (ISO)
papillary tumor of the pineal region  (ISO)
papillomavirus infectious disease  (ISO)
peripheral nervous system neoplasm  (ISO)
persistent fetal circulation syndrome  (IAGP)
Pneumococcal Pneumonia  (IMP)
polydactyly  (ISO)
portal hypertension  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (IAGP,ISO)
Prostate Cancer, Hereditary, 1  (ISO)
Prostate Cancer, Somatic  (ISO)
prostate carcinoma in situ  (IAGP,ISO)
prostatic hypertrophy  (IMP)
Prostatic Neoplasms  (IAGP,IMP,ISO)
Proteus syndrome  (ISO)
Pseudomonas Infections  (IMP)
PTEN hamartoma tumor syndrome  (IMP,ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Reperfusion Injury  (ISO)
retinitis pigmentosa  (ISO)
rhabdomyosarcoma  (ISO)
schizophrenia  (ISO)
Septic Peritonitis  (IMP)
Sezary's disease  (ISO)
silicosis  (ISO)
skin disease  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (IMP)
skin squamous cell carcinoma  (IGI)
Spinal Cord Injuries  (ISO)
sporadic breast cancer  (ISO)
squamous cell carcinoma  (ISO)
steatotic liver disease  (IAGP,IMP,ISO)
stomach cancer  (ISO)
stomach disease  (ISO)
substance-related disorder  (ISO)
thyroid gland follicular carcinoma  (IAGP)
Thyroid Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (IAGP,ISO)
uterine cancer  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)
uterine corpus cancer  (ISO)
visual epilepsy  (IMP)
X-linked VACTERL association  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
(R)-noradrenaline  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (EXP)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nitrophenol  (EXP)
4-nonylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxypsoralen  (ISO)
9-cis-retinoic acid  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
ammonium chloride  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
atorvastatin calcium  (ISO)
benomyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (EXP)
berberine  (EXP)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
biliverdin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calciol  (EXP,ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
carnosic acid  (ISO)
celastrol  (ISO)
chloroquine  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
ciglitazone  (ISO)
ciguatoxin CTX1B  (EXP)
cilostazol  (ISO)
cisplatin  (EXP,ISO)
cladribine  (ISO)
clodronic acid  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cucurbitacin E  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cytarabine  (ISO)
D-glucitol  (EXP,ISO)
dactolisib  (ISO)
daunorubicin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenhexamid  (ISO)
ferulic acid  (ISO)
flavanone  (ISO)
fludioxonil  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
geraniol  (ISO)
ginsenoside Rg1  (EXP)
glufosinate  (EXP)
gossypetin  (ISO)
graphene oxide  (ISO)
hemin  (ISO)
hesperetin  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroxyflutamide  (ISO)
indometacin  (ISO)
isoprenaline  (EXP,ISO)
ketoconazole  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (EXP,ISO)
lovastatin  (EXP,ISO)
lupeol  (ISO)
luteolin  (ISO)
LY294002  (ISO)
maculosin  (EXP)
malonaldehyde  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
methylseleninic acid  (ISO)
mevinphos  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
orlistat  (ISO)
osthole  (ISO)
oxybenzone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paxilline  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
peroxynitrous acid  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
phosphatidylcholine  (ISO)
phosphatidylethanolamine  (ISO)
pifithrin-?  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
plumbagin  (ISO)
potassium iodide  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
propofol  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resorcinol  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rivastigmine  (ISO)
rotenone  (EXP)
rutin  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sirolimus  (EXP,ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (ISO)
tetracycline  (EXP)
thalidomide  (ISO)
thymoquinone  (EXP)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
trovafloxacin  (EXP)
tubastatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
veliparib  (EXP)
vinclozolin  (ISO)
vinyl carbamate  (EXP)
vorinostat  (ISO)
WIN 55212-2  (ISO)
wortmannin  (ISO)
zearalenone  (EXP)
zinc atom  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (IMP)
angiogenesis  (IMP)
apoptotic process  (IGI)
B cell proliferation  (IMP)
brain morphogenesis  (IMP)
canonical Wnt signaling pathway  (ISO)
cardiac muscle tissue development  (IMP)
cell migration  (IMP)
cell motility  (IBA)
cell population proliferation  (IGI,IMP)
cellular response to decreased oxygen levels  (IDA)
cellular response to electrical stimulus  (ISO)
cellular response to ethanol  (ISO)
cellular response to hypoxia  (IDA)
cellular response to insulin stimulus  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to leptin stimulus  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
central nervous system development  (IMP)
central nervous system myelin maintenance  (IMP)
central nervous system neuron axonogenesis  (IMP)
dendritic spine morphogenesis  (IMP)
dentate gyrus development  (IMP)
endothelial cell migration  (IMP)
forebrain morphogenesis  (IMP)
gene expression  (IGI)
heart development  (IMP)
inositol phosphate catabolic process  (ISO)
learning or memory  (IMP)
lipid metabolic process  (IEA)
locomotor rhythm  (IMP)
locomotory behavior  (IMP)
long-term synaptic depression  (ISO)
long-term synaptic potentiation  (IMP)
male mating behavior  (IMP)
maternal behavior  (IMP)
memory  (ISO)
multicellular organismal response to stress  (IMP)
myelination  (IMP)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of axon regeneration  (IMP)
negative regulation of axonogenesis  (IMP)
negative regulation of B cell proliferation  (IMP)
negative regulation of cardiac muscle cell proliferation  (IGI,ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell cycle G1/S phase transition  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (IBA,IGI,ISO)
negative regulation of cell size  (IMP)
negative regulation of cellular senescence  (IMP)
negative regulation of defense response to bacterium  (ISO)
negative regulation of dendrite extension  (ISO)
negative regulation of dendritic spine morphogenesis  (IMP)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of excitatory postsynaptic potential  (IMP)
negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis  (ISO)
negative regulation of focal adhesion assembly  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of keratinocyte migration  (ISO)
negative regulation of myelination  (IMP)
negative regulation of neuron projection development  (ISO)
negative regulation of organ growth  (IMP)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of phagocytosis  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP,ISO)
negative regulation of potassium ion transmembrane transporter activity  (ISO)
negative regulation of protein phosphorylation  (IMP,ISO)
negative regulation of ribosome biogenesis  (IMP)
negative regulation of signaling receptor activity  (ISO)
negative regulation of synaptic vesicle clustering  (IMP)
negative regulation of T cell proliferation  (IMP)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of wound healing, spreading of epidermal cells  (ISO)
nervous system development  (IEA)
neuron projection development  (ISO)
neuron-neuron synaptic transmission  (IMP)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IMP)
phosphatidylinositol dephosphorylation  (IBA,ISO)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (IMP)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of excitatory postsynaptic potential  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (ISO)
postsynaptic density assembly  (IMP)
prepulse inhibition  (IMP)
presynaptic membrane assembly  (IMP)
prostate gland growth  (IMP)
protein dephosphorylation  (ISO)
protein stabilization  (ISO)
regulation of axon regeneration  (IGI)
regulation of B cell apoptotic process  (IMP)
regulation of cell cycle  (IGI)
regulation of cellular component size  (IMP)
regulation of cellular localization  (IMP)
regulation of Fc receptor mediated stimulatory signaling pathway  (ISO)
regulation of macrophage apoptotic process  (IMP)
regulation of neuron projection development  (IMP)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA)
regulation of protein stability  (ISO)
regulation of synaptic transmission, GABAergic  (IMP)
response to activity  (ISO)
response to arsenic-containing substance  (ISO)
response to ATP  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to glucose  (ISO)
response to inorganic substance  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
rhythmic synaptic transmission  (IMP)
social behavior  (IMP)
spindle assembly involved in female meiosis  (ISO)
synapse assembly  (IMP)
synapse maturation  (IMP)
T cell proliferation  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal alveolar macrophage morphology  (IAGP)
abnormal alveolocapillary membrane morphology  (IAGP)
abnormal anal canal morphology  (IAGP)
abnormal apoptosis  (IAGP)
abnormal astrocyte apoptosis  (IAGP)
abnormal astrocyte physiology  (IAGP)
abnormal B cell morphology  (IAGP)
abnormal B cell negative selection  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal behavior  (IAGP)
abnormal behavioral response to xenobiotic  (IAGP)
abnormal Bergmann glial cell differentiation  (IAGP)
abnormal Bergmann glial cell morphology  (IAGP)
abnormal bile duct morphology  (IAGP)
abnormal blood cell morphology/development  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal bone structure  (IAGP)
abnormal brain development  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal brain white matter morphology  (IAGP)
abnormal brainstem morphology  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal bronchiole morphology  (IAGP)
abnormal bronchus morphology  (IAGP)
abnormal brown adipose tissue morphology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal CD8-positive, alpha-beta T cell physiology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cellular cholesterol metabolism  (IAGP)
abnormal cellular respiration  (IAGP)
abnormal centroacinar cell of Langerhans morphology  (IAGP)
abnormal cerebellar foliation  (IAGP)
abnormal cerebellar granule cell morphology  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal cerebellar molecular layer  (IAGP)
abnormal cerebellar Purkinje cell layer  (IAGP)
abnormal cerebellum development  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebellum vermis morphology  (IAGP)
abnormal cerebral cortex pyramidal cell morphology  (IAGP)
abnormal cerebral hemisphere morphology  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal chromosome morphology  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal CNS synaptic transmission  (IAGP)
abnormal coat appearance  (IAGP)
abnormal colon morphology  (IAGP)
abnormal corpus callosum morphology  (IAGP)
abnormal corpus luteum morphology  (IAGP)
abnormal cortical ventricular zone morphology  (IAGP)
abnormal cystic duct morphology  (IAGP)
abnormal cytokine level  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal diaphragm morphology  (IAGP)
abnormal digestion  (IAGP)
abnormal dopaminergic neuron morphology  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endocytosis  (IAGP)
abnormal endometrium morphology  (IAGP)
abnormal enteric ganglia morphology  (IAGP)
abnormal enteric nervous system morphology  (IAGP)
abnormal enteric neuron morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis suprabasal layer morphology  (IAGP)
abnormal epididymis epithelium morphology  (IAGP)
abnormal epididymis morphology  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal estrous cycle  (IAGP)
abnormal excitatory postsynaptic currents  (IAGP)
abnormal exocrine pancreas morphology  (IAGP)
abnormal extrahepatic bile duct morphology  (IAGP)
abnormal fatty acids level  (IAGP)
abnormal gallbladder morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal glomerular capillary morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal glutamate-mediated receptor currents  (IAGP)
abnormal hair follicle regression  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hematopoietic stem cell morphology  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal hemopoiesis  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hepatocyte physiology  (IAGP)
abnormal hippocampal mossy fiber morphology  (IAGP)
abnormal hippocampus CA1 region morphology  (IAGP)
abnormal hippocampus granule cell morphology  (IAGP)
abnormal hippocampus layer morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal hippocampus pyramidal cell layer  (IAGP)
abnormal hippocampus pyramidal cell morphology  (IAGP)
abnormal innervation  (IAGP)
abnormal intestinal enteroendocrine cell morphology  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal involution of the mammary gland  (IAGP)
abnormal jejunum morphology  (IAGP)
abnormal kidney collecting duct morphology  (IAGP)
abnormal kidney cortex morphology  (IAGP)
abnormal kidney epithelium morphology  (IAGP)
abnormal kidney pelvis urothelium morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver sinusoid morphology  (IAGP)
abnormal liver size  (IAGP)
abnormal long bone epiphysis morphology  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung epithelium morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lung saccule morphology  (IAGP)
abnormal lung vasculature morphology  (IAGP)
abnormal lung-associated mesenchyme development  (IAGP)
abnormal luteolysis  (IAGP)
abnormal lymph node B cell domain morphology  (IAGP)
abnormal macrophage chemotaxis  (IAGP)
abnormal mammary gland epithelium morphology  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal mammary gland lobule morphology  (IAGP)
abnormal maternal decidual layer morphology  (IAGP)
abnormal maternal nurturing  (IAGP)
abnormal melanocyte morphology  (IAGP)
abnormal metastatic potential  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal miniature excitatory postsynaptic currents  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal mitophagy  (IAGP)
abnormal muscle fiber morphology  (IAGP)
abnormal myelin sheath morphology  (IAGP)
abnormal myeloid leukocyte morphology  (IAGP)
abnormal myometrium morphology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal nest building behavior  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal neuronal precursor proliferation  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal nipple morphology  (IAGP)
abnormal olfaction  (IAGP)
abnormal olfactory bulb development  (IAGP)
abnormal olfactory bulb mitral cell layer morphology  (IAGP)
abnormal olfactory bulb morphology  (IAGP)
abnormal oligodendrocyte morphology  (IAGP)
abnormal oocyte morphology  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal ovary physiology  (IAGP)
abnormal oviduct morphology  (IAGP)
abnormal pancreas physiology  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal pancreatic acinus morphology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal Paneth cell morphology  (IAGP)
abnormal pericardium development  (IAGP)
abnormal peripheral B cell anergy  (IAGP)
abnormal peritoneum morphology  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal placenta vasculature  (IAGP)
abnormal plasma cell morphology  (IAGP)
abnormal platelet activation  (IAGP)
abnormal postnatal subventricular zone morphology  (IAGP)
abnormal pregnancy  (IAGP)
abnormal primordial ovarian follicle morphology  (IAGP)
abnormal prostate gland duct morphology  (IAGP)
abnormal prostate gland epithelium morphology  (IAGP)
abnormal prostate gland morphology  (IAGP)
abnormal prostate gland physiology  (IAGP)
abnormal pulmonary alveolus epithelial cell morphology  (IAGP)
abnormal pulmonary neuroendocrine body morphology  (IAGP)
abnormal Purkinje cell dendrite morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal tubule epithelial cell primary cilium morphology  (IAGP)
abnormal renal/urinary system morphology  (IAGP)
abnormal renal/urinary system physiology  (IAGP)
abnormal reproductive system morphology  (IAGP)
abnormal respiratory epithelium morphology  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal response to CNS ischemic injury  (IAGP)
abnormal response to injury  (IAGP)
abnormal response to novel odor  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal salivary gland morphology  (IAGP)
abnormal Schwann cell morphology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal seminal vesicle morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal sexual interaction  (IAGP)
abnormal small intestinal crypt cell proliferation  (IAGP)
abnormal small intestinal villus morphology  (IAGP)
abnormal small intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal social investigation  (IAGP)
abnormal somite development  (IAGP)
abnormal spike wave discharge  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal striatum morphology  (IAGP)
abnormal substantia nigra pars compacta morphology  (IAGP)
abnormal substantia nigra pars reticulata morphology  (IAGP)
abnormal synapse morphology  (IAGP)
abnormal synaptic depression  (IAGP)
abnormal synaptic transmission  (IAGP)
abnormal synaptic vesicle number  (IAGP)
abnormal T cell number  (IAGP)
abnormal thymus physiology  (IAGP)
abnormal thyroid follicle morphology  (IAGP)
abnormal thyroid follicular cell morphology  (IAGP)
abnormal thyroid gland morphology  (IAGP)
abnormal trigeminal nerve morphology  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal tumor incidence  (IAGP)
abnormal tumor morphology  (IAGP)
abnormal tumor susceptibility  (IAGP)
abnormal type I pneumocyte morphology  (IAGP)
abnormal type II pneumocyte morphology  (IAGP)
abnormal ureter morphology  (IAGP)
abnormal urinary bladder mucosa morphology  (IAGP)
abnormal urinary bladder urothelium morphology  (IAGP)
abnormal urination  (IAGP)
abnormal urothelium morphology  (IAGP)
abnormal uterine cervix squamous epithelium morphology  (IAGP)
abnormal uterus morphology  (IAGP)
abnormal uterus physiology  (IAGP)
abnormal vas deferens morphology  (IAGP)
abnormal vascular development  (IAGP)
abnormal vasculogenesis  (IAGP)
abnormal vibrissa follicle morphology  (IAGP)
absent cerebellar foliation  (IAGP)
absent primordial ovarian follicles  (IAGP)
acanthosis  (IAGP)
alopecia  (IAGP)
anemia  (IAGP)
ascites  (IAGP)
astrocytosis  (IAGP)
ataxia  (IAGP)
bile duct hyperplasia  (IAGP)
branched small intestinal villi  (IAGP)
bronchial epithelial hyperplasia  (IAGP)
bronchiolar epithelial hyperplasia  (IAGP)
cardia bifida  (IAGP)
cardiac hypertrophy  (IAGP)
cataract  (IAGP)
colon polyps  (IAGP)
cyanosis  (IAGP)
decreased abdominal adipose tissue amount  (IAGP)
decreased aggression towards male mice  (IAGP)
decreased alveolar lamellar body number  (IAGP)
decreased B cell number  (IAGP)
decreased bleeding time  (IAGP)
decreased blood oxygen capacity  (IAGP)
decreased body size  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cellular sensitivity to oxidative stress  (IAGP)
decreased circulating estradiol level  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased circulating progesterone level  (IAGP)
decreased circulating thyroid-stimulating hormone level  (IAGP)
decreased embryo size  (IAGP)
decreased fasting circulating glucose level  (IAGP)
decreased granulosa cell apoptosis  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased hippocampus pyramidal cell number  (IAGP)
decreased IgG level  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased litter size  (IAGP)
decreased locomotor activity  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased mammary gland tumor incidence  (IAGP)
decreased myocardial infarct size  (IAGP)
decreased ovarian tumor incidence  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased prepulse inhibition  (IAGP)
decreased primordial ovarian follicle number  (IAGP)
decreased prostate gland tumor incidence  (IAGP)
decreased prostate gland weight  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased spleen germinal center number  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased surfactant secretion  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
decreased susceptibility to hepatic steatosis  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased T cell number  (IAGP)
decreased telomere length  (IAGP)
decreased thyroid-stimulating hormone level  (IAGP)
decreased thyroxine level  (IAGP)
decreased total body fat amount  (IAGP)
decreased tumor growth/size  (IAGP)
decreased tumor incidence  (IAGP)
decreased tumor latency  (IAGP)
decreased tumor-free survival time  (IAGP)
decreased uterine NK cell number  (IAGP)
decreased uterus weight  (IAGP)
dilated gallbladder  (IAGP)
disheveled coat  (IAGP)
disorganized embryonic tissue  (IAGP)
disorganized mitochondrial cristae  (IAGP)
distended abdomen  (IAGP)
distended cecum  (IAGP)
ectopic Bergmann glia cells  (IAGP)
ectopic cartilage  (IAGP)
ectopic cerebellar granule cells  (IAGP)
ectopic neuron  (IAGP)
ectopic Purkinje cell  (IAGP)
ectopic ureteric bud  (IAGP)
edema  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
endometrium fibrosis  (IAGP)
endometrium hyperplasia  (IAGP)
enhanced female fertility  (IAGP)
enhanced skeletal muscle regeneration  (IAGP)
enlarged allantois  (IAGP)
enlarged cerebellum  (IAGP)
enlarged dorsal root ganglion  (IAGP)
enlarged hair follicles  (IAGP)
enlarged heart  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged ovary  (IAGP)
enlarged pancreatic islets  (IAGP)
enlarged Peyer's patches  (IAGP)
enlarged prostate gland  (IAGP)
enlarged prostate gland anterior lobe  (IAGP)
enlarged spleen  (IAGP)
enlarged thymus  (IAGP)
enlarged thyroid gland  (IAGP)
enlarged urinary bladder  (IAGP)
enlarged uterus  (IAGP)
epidermal hyperplasia  (IAGP)
epithelioid cyst  (IAGP)
exocrine pancreas atrophy  (IAGP)
extended life span  (IAGP)
extramedullary hematopoiesis  (IAGP)
eyelids open at birth  (IAGP)
failure of chorioallantoic fusion  (IAGP)
failure of initiation of embryo turning  (IAGP)
fast extinction of fear memory  (IAGP)
female infertility  (IAGP)
flaky skin  (IAGP)
gliosis  (IAGP)
hair follicle outer root sheath hyperplasia  (IAGP)
hemorrhage  (IAGP)
hemorrhagic ascites  (IAGP)
hepatic steatosis  (IAGP)
hindlimb paralysis  (IAGP)
hippocampal neuron degeneration  (IAGP)
hunched posture  (IAGP)
hydrocephaly  (IAGP)
hydronephrosis  (IAGP)
hyperglycemia  (IAGP)
hyperkeratosis  (IAGP)
hypermyelination  (IAGP)
hyperpigmentation  (IAGP)
hypoglycemia  (IAGP)
hypoxia  (IAGP)
impaired balance  (IAGP)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
impaired glucose tolerance  (IAGP)
impaired granulosa cell differentiation  (IAGP)
impaired lipolysis  (IAGP)
impaired luteal cell differentiation  (IAGP)
impaired neutrophil recruitment  (IAGP)
impaired olfaction  (IAGP)
impaired spatial learning  (IAGP)
improved glucose tolerance  (IAGP)
incomplete embryo turning  (IAGP)
increased activity of thyroid gland  (IAGP)
increased acute lymphoblastic leukemia incidence  (IAGP)
increased acute promyelocytic leukemia incidence  (IAGP)
increased adenocarcinoma incidence  (IAGP)
increased adenoma incidence  (IAGP)
increased adrenal gland tumor incidence  (IAGP)
increased angiogenesis  (IAGP)
increased anxiety-related response  (IAGP)
increased astrocyte number  (IAGP)
increased astrocytoma incidence  (IAGP)
increased B cell apoptosis  (IAGP)
increased B cell number  (IAGP)
increased B cell proliferation  (IAGP)
increased B-1 B cell number  (IAGP)
increased body length  (IAGP)
increased body weight  (IAGP)
increased bone mineral density  (IAGP)
increased brain size  (IAGP)
increased brain tumor incidence  (IAGP)
increased brain weight  (IAGP)
increased bronchioalveolar stem cell number  (IAGP)
increased carcinoma incidence  (IAGP)
increased cardiac muscle contractility  (IAGP)
increased cell proliferation  (IAGP)
increased cholangiocarcinoma incidence  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased circulating thyroxine level  (IAGP)
increased circulating triiodothyronine level  (IAGP)
increased classified tumor incidence  (IAGP)
increased club cell number  (IAGP)
increased colon adenocarcinoma incidence  (IAGP)
increased corpora lutea number  (IAGP)
increased cutaneous melanoma incidence  (IAGP)
increased dendritic spine density  (IAGP)
increased dentate gyrus size  (IAGP)
increased dopamine level  (IAGP)
increased endometrial carcinoma incidence  (IAGP)
increased epididymal cystadenoma incidence  (IAGP)
increased fibroadenoma incidence  (IAGP)
increased follicle stimulating hormone level  (IAGP)
increased follicular lymphoma incidence  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased germinal center B cell number  (IAGP)
increased glioblastoma incidence  (IAGP)
increased glioma incidence  (IAGP)
increased glutamic acid level  (IAGP)
increased granulocyte number  (IAGP)
increased granulosa cell proliferation  (IAGP)
increased granulosa cell tumor incidence  (IAGP)
increased hair follicle cell proliferation  (IAGP)
increased hamartoma incidence  (IAGP)
increased hemangioma incidence  (IAGP)
increased hemolymphoid system tumor incidence  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased hepatocyte number  (IAGP)
increased hepatocyte proliferation  (IAGP)
increased IgG1 level  (IAGP)
increased IgM level  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased incidence of tumors by ionizing radiation induction  (IAGP)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased intestinal adenoma incidence  (IAGP)
increased keratinocyte proliferation  (IAGP)
increased kidney cell proliferation  (IAGP)
increased kidney weight  (IAGP)
increased leukemia incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased liposarcoma incidence  (IAGP)
increased liver adenoma incidence  (IAGP)
increased liver cholesterol level  (IAGP)
increased liver glycogen level  (IAGP)
increased liver triglyceride level  (IAGP)
increased liver tumor incidence  (IAGP)
increased liver weight  (IAGP)
increased locomotor activity  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung adenoma incidence  (IAGP)
increased lung carcinoma incidence  (IAGP)
increased lung endothelial cell proliferation  (IAGP)
increased lung small cell carcinoma incidence  (IAGP)
increased lung squamous cell carcinoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased luteinizing hormone level  (IAGP)
increased lymphoma incidence  (IAGP)
increased macrophage cell number  (IAGP)
increased malignant tumor incidence  (IAGP)
increased mammary adenoacanthoma incidence  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased mammary gland ductal carcinoma incidence  (IAGP)
increased mammary gland tumor incidence  (IAGP)
increased mammary gland tumor incidence in breeding females  (IAGP)
increased marginal zone B cell number  (IAGP)
increased medulloblastoma incidence  (IAGP)
increased melanoma incidence  (IAGP)
increased memory B cell number  (IAGP)
increased mesenchymal cell proliferation involved in lung development  (IAGP)
increased metastatic potential  (IAGP)
increased miniature excitatory postsynaptic current amplitude  (IAGP)
increased miniature excitatory postsynaptic current frequency  (IAGP)
increased monocyte cell number  (IAGP)
increased myocardial fiber mitochondrial DNA content  (IAGP)
increased myocardial fiber size  (IAGP)
increased myocardial infarct size  (IAGP)
increased myoepithelioma incidence  (IAGP)
increased nervous system tumor incidence  (IAGP)
increased neurofibroma incidence  (IAGP)
increased neurofibrosarcoma incidence  (IAGP)
increased neuronal precursor cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased oligodendrocyte number  (IAGP)
increased oligodendroglioma incidence  (IAGP)
increased oral papilloma incidence  (IAGP)
increased organ/body region tumor incidence  (IAGP)
increased ovarian carcinoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pancreas tumor incidence  (IAGP)
increased pancreatic acinar cell carcinoma incidence  (IAGP)
increased pancreatic acinar cell number  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased pancreatic beta cell number  (IAGP)
increased pancreatic beta cell proliferation  (IAGP)
increased pancreatic ductal adenocarcinoma incidence  (IAGP)
increased pancreatic intraepithelial neoplasia incidence  (IAGP)
increased pancreatic islet number  (IAGP)
increased papilloma incidence  (IAGP)
increased pheochromocytoma incidence  (IAGP)
increased plasmacytoma incidence  (IAGP)
increased platelet aggregation  (IAGP)
increased prostate gland adenocarcinoma incidence  (IAGP)
increased prostate gland tumor incidence  (IAGP)
increased prostate gland weight  (IAGP)
increased prostate intraepithelial neoplasia incidence  (IAGP)
increased renal carcinoma incidence  (IAGP)
increased salivary adenocarcinoma incidence  (IAGP)
increased saturated fatty acids level  (IAGP)
increased skin hamartoma incidence  (IAGP)
increased skin papilloma incidence  (IAGP)
increased skin squamous cell carcinoma incidence  (IAGP)
increased skin tumor incidence  (IAGP)
increased solitary pulmonary neuroendocrine cell number  (IAGP)
increased spindle cell carcinoma incidence  (IAGP)
increased spleen weight  (IAGP)
increased spleen white pulp amount  (IAGP)
increased splenic marginal zone lymphoma incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased startle reflex  (IAGP)
increased stereotypic behavior  (IAGP)
increased stomach tumor incidence  (IAGP)
increased superovulation rate  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to myocardial ischemic injury  (IAGP)
increased T cell acute lymphoblastic leukemia incidence  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T follicular helper cell number  (IAGP)
increased telomere length  (IAGP)
increased teratoma incidence  (IAGP)
increased testis tumor incidence  (IAGP)
increased thigmotaxis  (IAGP)
increased thyroid adenoma incidence  (IAGP)
increased thyroid carcinoma incidence  (IAGP)
increased thyroid tumor incidence  (IAGP)
increased thyroid-stimulating hormone level  (IAGP)
increased thyroxine level  (IAGP)
increased tumor growth/size  (IAGP)
increased tumor incidence  (IAGP)
increased tumor latency  (IAGP)
increased urethra carcinoma incidence  (IAGP)
increased urinary bladder carcinoma incidence  (IAGP)
increased urinary bladder transitional cell carcinoma incidence  (IAGP)
increased uterus carcinoma incidence  (IAGP)
increased uterus weight  (IAGP)
insulin resistance  (IAGP)
intestine polyps  (IAGP)
jaundice  (IAGP)
kidney cortex cyst  (IAGP)
kidney cyst  (IAGP)
kidney failure  (IAGP)
kidney medulla cyst  (IAGP)
kinked neural tube  (IAGP)
kyphosis  (IAGP)
lethality at weaning, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lethargy  (IAGP)
lipodystrophy  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
long tail  (IAGP)
lung inflammation  (IAGP)
lymph node hyperplasia  (IAGP)
lymphoid hyperplasia  (IAGP)
macrovesicular hepatic steatosis  (IAGP)
Mallory bodies  (IAGP)
mammary gland duct hyperplasia  (IAGP)
mammary gland hyperplasia  (IAGP)
megacephaly  (IAGP)
megacolon  (IAGP)
microvesicular hepatic steatosis  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
neuron hypertrophy  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
optic nerve atrophy  (IAGP)
ovary hemorrhage  (IAGP)
oxidative stress  (IAGP)
pale liver  (IAGP)
pancreatic acinar-to-ductal metaplasia  (IAGP)
pancreatic islet hyperplasia  (IAGP)
paralysis  (IAGP)
penis prolapse  (IAGP)
peritoneal inflammation  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
premature ovarian failure  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
prostate gland anterior lobe hyperplasia  (IAGP)
prostate gland cyst  (IAGP)
prostate gland dorsolateral lobe hyperplasia  (IAGP)
prostate gland epithelial hyperplasia  (IAGP)
prostate gland hyperplasia  (IAGP)
prostate gland inflammation  (IAGP)
pulmonary edema  (IAGP)
pulmonary embolism  (IAGP)
pulmonary hyperplasia  (IAGP)
Purkinje cell degeneration  (IAGP)
pyelonephritis  (IAGP)
reduced female fertility  (IAGP)
reduced fertility  (IAGP)
reduced long-term potentiation  (IAGP)
reduced sensorimotor gating  (IAGP)
respiratory acidosis  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
retina degeneration  (IAGP)
retina ganglion cell degeneration  (IAGP)
retina outer nuclear layer degeneration  (IAGP)
ruffled hair  (IAGP)
seizures  (IAGP)
seminiferous tubule degeneration  (IAGP)
skin lesions  (IAGP)
slow postnatal weight gain  (IAGP)
small heart  (IAGP)
small lung saccule  (IAGP)
spleen hyperplasia  (IAGP)
spontaneous skin ulceration  (IAGP)
sporadic seizures  (IAGP)
stomach mucosa hyperplasia  (IAGP)
suppressed circulating follicle stimulating hormone level  (IAGP)
tachypnea  (IAGP)
thick epidermis  (IAGP)
thick epidermis stratum basale  (IAGP)
thick epidermis suprabasal layer  (IAGP)
thick hair follicle outer root sheath  (IAGP)
thick skin  (IAGP)
thickened cerebral cortex  (IAGP)
thin cerebellar granule layer  (IAGP)
thin retina ganglion layer  (IAGP)
thin retina inner nuclear layer  (IAGP)
thin retina outer nuclear layer  (IAGP)
thrombocytosis  (IAGP)
thyroid gland hyperplasia  (IAGP)
tomacula  (IAGP)
tonic-clonic seizures  (IAGP)
unidirectional circling  (IAGP)
urinary bladder obstruction  (IAGP)
uterus hyperplasia  (IAGP)
wavy neural tube  (IAGP)
weakness  (IAGP)
weight loss  (IAGP)
wrinkled skin  (IAGP)
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77. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
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83. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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105. Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma. Wang X, etal., Oncogene. 2020 Oct;39(40):6286-6299. doi: 10.1038/s41388-020-01434-5. Epub 2020 Aug 25.
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PMID:35607965   PMID:35624211   PMID:35649375   PMID:35653190   PMID:35675421   PMID:35676931   PMID:35697130   PMID:35703180   PMID:35767994   PMID:35775322   PMID:35780838   PMID:35822655  
PMID:35853870   PMID:35867798   PMID:35911788   PMID:35924448   PMID:35954335   PMID:35954439   PMID:36051438   PMID:36052752   PMID:36073856   PMID:36078116   PMID:36102787   PMID:36131018  
PMID:36149763   PMID:36150390   PMID:36170840   PMID:36171333   PMID:36217693   PMID:36242915   PMID:36291720   PMID:36305462   PMID:36323257   PMID:36331296   PMID:36339257   PMID:36368445  
PMID:36370710   PMID:36377658   PMID:36417873   PMID:36436593   PMID:36456551   PMID:36473627   PMID:36511483   PMID:36528691   PMID:36533329   PMID:36551505   PMID:36592799   PMID:36599297  
PMID:36634201   PMID:36656901   PMID:36672468   PMID:36707509   PMID:36759189   PMID:36764478   PMID:36841836   PMID:36854750   PMID:36882525   PMID:36897957   PMID:36918564   PMID:36930333  
PMID:36982451   PMID:36991255   PMID:37023120   PMID:37024714   PMID:37028516   PMID:37055829   PMID:37060563   PMID:37061917   PMID:37067907   PMID:37076617   PMID:37084991   PMID:37172587  
PMID:37185447   PMID:37225693   PMID:37255534   PMID:37291517   PMID:37311042   PMID:37335131   PMID:37384528   PMID:37386128   PMID:37405670   PMID:37406985   PMID:37418003   PMID:37451271  
PMID:37494420   PMID:37496993   PMID:37516803   PMID:37532934   PMID:37543582   PMID:37558155   PMID:37561626   PMID:37567175   PMID:37587334   PMID:37589076   PMID:37597423   PMID:37606694  
PMID:37644036   PMID:37658191   PMID:37673853   PMID:37704631   PMID:37721526   PMID:37733448   PMID:37778650   PMID:37804830   PMID:37839992   PMID:37848024   PMID:37850885   PMID:37851112  
PMID:37875657   PMID:37940999   PMID:37991903   PMID:38041812   PMID:38060346   PMID:38096816   PMID:38114855   PMID:38148377   PMID:38233537   PMID:38279488   PMID:38326829   PMID:38330136  
PMID:38365726   PMID:38411613   PMID:38416830   PMID:38442201   PMID:38446016   PMID:38459588   PMID:38540765  


Genomics

Comparative Map Data
Pten
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391932,734,977 - 32,803,560 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1932,734,897 - 32,803,560 (+)EnsemblGRCm39 Ensembl
GRCm381932,757,577 - 32,826,160 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1932,757,497 - 32,826,160 (+)EnsemblGRCm38mm10GRCm38
MGSCv371932,832,067 - 32,900,650 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361932,823,574 - 32,892,157 (+)NCBIMGSCv36mm8
Celera1933,541,182 - 33,610,051 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1928.14NCBI
PTEN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381087,863,625 - 87,971,930 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1087,862,638 - 87,971,930 (+)EnsemblGRCh38hg38GRCh38
GRCh371089,623,382 - 89,731,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361089,613,175 - 89,718,512 (+)NCBINCBI36Build 36hg18NCBI36
Build 341089,613,174 - 89,716,382NCBI
Celera1083,369,676 - 83,474,975 (+)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1083,258,013 - 83,363,313 (+)NCBIHuRef
CHM1_11089,905,493 - 90,010,826 (+)NCBICHM1_1
T2T-CHM13v2.01088,747,528 - 88,855,830 (+)NCBIT2T-CHM13v2.0
Pten
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,043,707 - 240,110,330 (+)NCBIGRCr8
mRatBN7.21230,630,443 - 230,697,070 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1230,630,338 - 230,696,838 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1239,010,509 - 239,075,549 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01245,940,213 - 246,005,253 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01238,778,317 - 238,843,363 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01251,421,814 - 251,487,634 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,421,596 - 251,487,832 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01258,651,829 - 258,717,009 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,771,027 - 236,837,261 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11236,935,049 - 237,001,284 (+)NCBI
Celera1227,746,622 - 227,812,108 (+)NCBICelera
Cytogenetic Map1q52NCBI
Pten
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554255,014,147 - 5,091,829 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554255,007,811 - 5,091,829 (-)NCBIChiLan1.0ChiLan1.0
PTEN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2899,880,836 - 99,988,640 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11099,886,147 - 99,990,806 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01084,587,841 - 84,689,043 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11088,093,539 - 88,197,902 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1088,093,539 - 88,194,605 (+)Ensemblpanpan1.1panPan2
PTEN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12637,853,148 - 37,913,176 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2637,835,661 - 37,913,176 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2637,711,222 - 37,730,964 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02639,359,420 - 39,447,205 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2639,359,407 - 39,447,189 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12637,265,630 - 37,349,813 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02636,847,668 - 36,931,645 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02638,118,261 - 38,202,372 (+)NCBIUU_Cfam_GSD_1.0
Pten
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721377,454,602 - 77,542,975 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367351,252,414 - 1,338,323 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367351,252,414 - 1,338,318 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTEN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11499,929,590 - 100,021,619 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214108,911,519 - 109,003,081 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTEN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1981,308,058 - 81,412,386 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl981,309,099 - 81,409,146 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604841,972,612 - 42,077,014 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pten
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479113,975,235 - 14,056,900 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pten
2096 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2214
Count of miRNA genes:769
Interacting mature miRNAs:1060
Transcripts:ENSMUST00000013807, ENSMUST00000140014, ENSMUST00000154806
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192198409132912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
1357568Tgct4_mtesticular germ cell tumor 4 (mouse)Not determined192777198535295381Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse

Markers in Region
D19Mit64  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381932,796,630 - 32,796,722UniSTSGRCm38
MGSCv371932,871,120 - 32,871,212UniSTSGRCm37
Celera1933,580,516 - 33,580,608UniSTS
Cytogenetic Map19C1UniSTS
cM Map1942.0UniSTS
Whitehead Genetic1924.0UniSTS
Whitehead_YAC19 UniSTS
AI463227  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381932,825,084 - 32,825,294UniSTSGRCm38
MGSCv371932,899,574 - 32,899,784UniSTSGRCm37
Celera1933,608,975 - 33,609,185UniSTS
Cytogenetic Map19C1UniSTS
cM Map1924.5UniSTS
Whitehead/MRC_RH19321.06UniSTS
PMC270016P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381932,801,541 - 32,801,884UniSTSGRCm38
MGSCv371932,876,031 - 32,876,374UniSTSGRCm37
Celera1933,585,427 - 33,585,770UniSTS
Cytogenetic Map19C1UniSTS
cM Map1924.5UniSTS
PTEN_234  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381932,820,130 - 32,821,019UniSTSGRCm38
MGSCv371932,894,620 - 32,895,509UniSTSGRCm37
Celera1933,604,019 - 33,604,908UniSTS
Cytogenetic Map19C1UniSTS
cM Map1924.5UniSTS
Pten  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C1UniSTS
cM Map1924.5UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006526769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC087098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC162887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK008841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU701098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK616227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KX421108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK783287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN251747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN251748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN251749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN251750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U92437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000013807   ⟹   ENSMUSP00000013807
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1932,734,897 - 32,803,560 (+)Ensembl
GRCm38.p6 Ensembl1932,757,497 - 32,826,160 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140014
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1932,734,995 - 32,780,243 (+)Ensembl
GRCm38.p6 Ensembl1932,757,595 - 32,802,843 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154806
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1932,788,625 - 32,795,377 (+)Ensembl
GRCm38.p6 Ensembl1932,811,225 - 32,817,977 (+)Ensembl
RefSeq Acc Id: ENSMUST00000249247   ⟹   ENSMUSP00000159627
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1932,734,897 - 32,803,560 (+)Ensembl
RefSeq Acc Id: NM_008960   ⟹   NP_032986
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391932,734,977 - 32,803,560 (+)NCBI
GRCm381932,757,577 - 32,826,160 (+)ENTREZGENE
MGSCv371932,832,067 - 32,900,650 (+)RGD
Celera1933,541,182 - 33,610,051 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006526769   ⟹   XP_006526832
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391932,735,930 - 32,803,453 (+)NCBI
GRCm381932,758,530 - 32,825,757 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032986   ⟸   NM_008960
- UniProtKB: Q3UFB0 (UniProtKB/Swiss-Prot),   Q542G1 (UniProtKB/Swiss-Prot),   O08586 (UniProtKB/Swiss-Prot),   A0A6G7SF19 (UniProtKB/TrEMBL),   A0A6G7SEK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006526832   ⟸   XM_006526769
- Peptide Label: isoform X1
- UniProtKB: Q8BSR7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000013807   ⟸   ENSMUST00000013807
RefSeq Acc Id: ENSMUSP00000159627   ⟸   ENSMUST00000249247
Protein Domains
C2 tensin-type   Phosphatase tensin-type   Tyrosine specific protein phosphatases

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08586-F1-model_v2 AlphaFold O08586 1-403 view protein structure

Promoters
RGD ID:13679276
Promoter ID:EPDNEW_M23787
Type:initiation region
Name:Pten_1
Description:Mus musculus phosphatase and tensin homolog , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23788  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381932,757,623 - 32,757,683EPDNEW
RGD ID:13679278
Promoter ID:EPDNEW_M23788
Type:single initiation site
Name:Pten_2
Description:Mus musculus phosphatase and tensin homolog , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23787  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381932,757,840 - 32,757,900EPDNEW
RGD ID:6847582
Promoter ID:MM_ACW:26588
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   Liver,   Lung
Transcripts:PTEN.HSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361932,830,121 - 32,830,621 (+)MPROMDB
RGD ID:6830342
Promoter ID:MM_KWN:26861
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000050229,   UC008HFQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361932,831,001 - 32,832,932 (+)MPROMDB
RGD ID:6830344
Promoter ID:MM_KWN:26863
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   Brain,   Liver
Transcripts:OTTMUST00000050231
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361932,885,116 - 32,886,237 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109583 AgrOrtholog
Ensembl Genes ENSMUSG00000013663 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000013807 ENTREZGENE
  ENSMUST00000013807.8 UniProtKB/Swiss-Prot
  ENSMUST00000249247.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.1110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Bifunc_PIno_P3_Pase/Pase_PTEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTP_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTP_PTEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tensin_C2-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tensin_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109583 ENTREZGENE
NCBI Gene 19211 ENTREZGENE
PANTHER PHOSPHATASE WITH HOMOLOGY TO TENSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PTEN_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PTEN RGD
PhenoGen Pten PhenoGen
PIRSF PTEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C2_TENSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPASE_TENSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTEN_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPlike_phytase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024QYR9_MOUSE UniProtKB/TrEMBL
  A0A1V0DNR6_MOUSE UniProtKB/TrEMBL
  A0A6G6A824_MOUSE UniProtKB/TrEMBL
  A0A6G7SEK5 ENTREZGENE, UniProtKB/TrEMBL
  A0A6G7SF19 ENTREZGENE, UniProtKB/TrEMBL
  O08586 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3UFB0 ENTREZGENE
  Q3UUN5_MOUSE UniProtKB/TrEMBL
  Q3UUT8_MOUSE UniProtKB/TrEMBL
  Q542G1 ENTREZGENE
  Q8BJP9_MOUSE UniProtKB/TrEMBL
  Q8BSR7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q3UFB0 UniProtKB/Swiss-Prot
  Q542G1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Pten  phosphatase and tensin homolog  B430203M17Rik  RIKEN cDNA B430203M17 gene  Data merged from RGD:1621238 737654 PROVISIONAL