Gene: Plekha1 (pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1)
Mus musculus
Symbol:
Plekha1
Name:
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Description:
ENCODES a protein that exhibits PDZ domain binding (ortholog); phosphatidylinositol-3,4-bisphosphate binding (ortholog); INVOLVED IN androgen metabolic process; estrogen metabolic process; face morphogenesis; PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH abnormal cardiac cell glucose uptake; abnormal frontal bone morphology; abnormal muscle cell glucose uptake; ASSOCIATED WITH Macular Degeneration (ortholog); Macular Degeneration, Age-Related, 1 (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; choline
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
AA960558; C920009D07Rik; OTTMUSP00000037143; OTTMUSP00000037144; OTTMUSP00000037145; PH domain-containing family A member 1; pleckstrin homology domain-containing family A member 1; tandem PH domain-containing protein 1; TAPP-1; TAPP1
Orthologs:
Homo sapiens : PLEKHA1
(pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1)
HGNC
Rattus norvegicus : Plekha1
(pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 7 130,865,910 - 130,913,302 + NCBI Mouse cM Map 7 + NCBI Mouse Celera Assembly 7 130,676,697 - 130,724,178 + NCBI Mouse Genome Assembly Build 37 7 138,009,424 - 138,056,816 + NCBI Mouse Genome Assembly Build 36.1 7 138,009,424 - 138,056,816 + NCBI Mouse Cytogenetic Map 7 F3 NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1345011 6480464 Tetrachlorodibenzodioxin affects the expression of PLEKHA1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1564153 6480464 Tetrachlorodibenzodioxin results in increased expression of PLEKHA1 mRNA CTD PMID:20959002 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PLEKHA1 mRNA CTD PMID:21570461 benzo[a]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of PLEKHA1 mRNA CTD PMID:21715664 chloroprene increases expression ISO RGD:1564153 6480464 Chloroprene results in increased expression of PLEKHA1 mRNA CTD PMID:23125180 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLEKHA1 mRNA CTD PMID:20938992 clofibrate multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of PLEKHA1 mRNA; more ... CTD PMID:17585979 copper(2+) sulfate increases expression ISO RGD:1345011 6480464 Copper Sulfate results in increased expression of PLEKHA1 mRNA CTD PMID:19549813 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLEKHA1 mRNA CTD PMID:20938992 hydrogen peroxide multiple interactions ISO RGD:1345011 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PLEKHA1 protein CTD PMID:18951874 hydrogen peroxide increases expression ISO RGD:1345011 6480464 Hydrogen Peroxide results in increased expression of PLEKHA1 mRNA CTD PMID:18951874 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLEKHA1 mRNA CTD PMID:20938992 menadione affects expression ISO RGD:1345011 6480464 Vitamin K 3 affects the expression of PLEKHA1 mRNA CTD PMID:20044591 paracetamol multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of PLEKHA1 mRNA; more ... CTD PMID:17585979 paracetamol decreases expression ISO RGD:1345011 6480464 Acetaminophen results in decreased expression of PLEKHA1 mRNA CTD PMID:21420995 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of PLEKHA1 mRNA CTD PMID:17562736 perfluorooctanoic acid increases expression ISO RGD:1564153 6480464 perfluorooctanoic acid results in increased expression of PLEKHA1 mRNA CTD PMID:19162173 phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of PLEKHA1 mRNA CTD PMID:19136022 pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of PLEKHA1 mRNA CTD PMID:19136022 pirinixic acid increases expression ISO RGD:1564153 6480464 pirinixic acid results in increased expression of PLEKHA1 mRNA CTD PMID:19162173 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of PLEKHA1 mRNA CTD PMID:17426115 testosterone enanthate affects expression ISO RGD:1345011 6480464 testosterone enanthate affects the expression of PLEKHA1 mRNA CTD PMID:17440010 theophylline multiple interactions ISO RGD:1345011 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of PLEKHA1 protein CTD PMID:18951874 valproic acid increases expression ISO RGD:1345011 6480464 Valproic Acid results in increased expression of PLEKHA1 mRNA CTD PMID:19101580
Biological Process
androgen metabolic process IMP MGI:MGI:3526857 2290270 MGI:MGI:3820330|PMID:19056881 MGI MGI:MGI:3820330 PMID:19056881 B cell receptor signaling pathway ISO UniProtKB:Q9HB21 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 cellular response to hydrogen peroxide ISO UniProtKB:Q9HB21 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 establishment of protein localization ISO UniProtKB:Q9HB21 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 estrogen metabolic process IGI MGI:MGI:97530 2290270 MGI:MGI:3820330|PMID:19056881 MGI MGI:MGI:3820330 PMID:19056881 face morphogenesis IMP MGI:MGI:3526857 2290270 MGI:MGI:3696608|PMID:17143286 MGI MGI:MGI:3696608 PMID:17143286 female gonad development IGI MGI:MGI:97530 2290270 MGI:MGI:3820330|PMID:19056881 MGI MGI:MGI:3820330 PMID:19056881 Leydig cell differentiation IMP MGI:MGI:3526857 2290270 MGI:MGI:3820330|PMID:19056881 MGI MGI:MGI:3820330 PMID:19056881 luteinization IGI MGI:MGI:97530 2290270 MGI:MGI:3820330|PMID:19056881 MGI MGI:MGI:3820330 PMID:19056881 multicellular organism growth IMP MGI:MGI:3526857 2290270 MGI:MGI:3696608|PMID:17143286 MGI MGI:MGI:3696608 PMID:17143286 negative regulation of protein kinase B signaling cascade ISO UniProtKB:Q9HB21 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 palate development IMP MGI:MGI:3526857 2290270 MGI:MGI:3696608|PMID:17143286 MGI MGI:MGI:3696608 PMID:17143286 phosphatidylinositol 3-kinase cascade ISO UniProtKB:Q9HB21 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 platelet-derived growth factor receptor signaling pathway IMP MGI:MGI:3526857 2290270 MGI:MGI:3696608|PMID:17143286 MGI MGI:MGI:3696608 PMID:17143286 post-embryonic development IMP MGI:MGI:3526857 2290270 MGI:MGI:3696608|PMID:17143286 MGI MGI:MGI:3696608 PMID:17143286 ruffle organization ISO UniProtKB:Q9HB21 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 skeletal system morphogenesis IMP MGI:MGI:3526857 2290270 MGI:MGI:3696608|PMID:17143286 MGI MGI:MGI:3696608 PMID:17143286 spermatogenesis IMP MGI:MGI:3526857 2290270 MGI:MGI:3820330|PMID:19056881 MGI MGI:MGI:3820330 PMID:19056881
Cellular Component
cytoplasm ISO UniProtKB:Q9HB21 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 membrane IEA UniProtKB-KW:KW-0472 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 nucleus ISO UniProtKB:Q9HB21 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 plasma membrane ISO UniProtKB:Q9HB21 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 ruffle membrane ISO UniProtKB:Q9HB21 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177
Molecular Function
lipid binding IEA UniProtKB-KW:KW-0446 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 PDZ domain binding ISO UniProtKB:Q9HB21 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 phosphatidylinositol-3,4-bisphosphate binding ISO UniProtKB:Q9HB21 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 phospholipid binding IEA InterPro:IPR001849 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098
4142050 Hemq3_m hematocrit QTL 3 (mouse) Not determined 7 105709201 139709289 Mouse 1357432 Hdlcl1_m HDL cholesterol level 1 (mouse) Not determined 7 105709201 139709289 Mouse 1301478 Eae26_m susceptibility to experimental allergic encephalomyelitis 26 (mouse) Not determined 7 105709201 139709289 Mouse 1301447 Fembm3_m femoral bone morphometry 3 (mouse) Not determined 7 108537552 142537633 Mouse 4141896 Ccmp5_m cerebellar cAMP 5 (mouse) Not determined 7 108537552 142537633 Mouse 1558713 Ethm3_m ethanol induced thermoregulation 3 (mouse) Not determined 7 108537552 142537633 Mouse 1301105 Cfld4_m cystic fibrosis lung disease 4 (mouse) Not determined 7 109237672 143237821 Mouse 1300721 Cfbw3_m cystic fibrosis body weight 3 (mouse) Not determined 7 109237672 143237821 Mouse 1357460 Vtbt4_m vertebral trabecular bone trait 4 (mouse) Not determined 7 109237672 143237821 Mouse 4142312 Nilac4_m nicotine induced locomotor activity 4 (mouse) Not determined 7 110029510 144029671 Mouse 1300550 Szv2_m seizure severity 2 (mouse) Not determined 7 110029510 144029671 Mouse 1301680 Vpantd_m VPA induced neural tube defect (mouse) Not determined 7 112629838 146629943 Mouse 1301200 Mob1_m multigenic obesity 1 (mouse) Not determined 7 112794954 146795102 Mouse 5491192 Mobq1_m multigenic obesity QTL 1 (mouse) Not determined 7 112794954 146795102 Mouse 1357663 Rthyd1_m resistance to thymic deletion 1 (mouse) Not determined 7 115776553 149776641 Mouse 1558880 Scc12_m colon tumor susceptibility 12 (mouse) Not determined 7 118509025 152509126 Mouse 1300670 Sluc19_m susceptibility to lung cancer 19 (mouse) Not determined 7 118707912 152509964 Mouse 1301898 Alcp14_m alcohol preference locus 14 (mouse) Not determined 7 118707912 152509964 Mouse 1302032 Alcp12_m alcohol preference locus 12 (mouse) Not determined 7 118707912 152509964 Mouse 1300635 Dice2_m determination of interleukin 4 commitment 2 (mouse) Not determined 7 119360966 152509964 Mouse 1300747 Skts2_m skin tumor susceptibility 2 (mouse) Not determined 7 120464517 152509964 Mouse 1357462 Hlbsb1_m hepatic lipase activity in BSB 1 (mouse) Not determined 7 120807110 152509964 Mouse 4142224 Cia42_m collagen induced arthritis 42 (mouse) Not determined 7 122448713 152509964 Mouse 1301470 Vmbic3_m ventral midbrain iron content 3 (mouse) Not determined 7 122448713 152509964 Mouse 1300677 Bmd9_m bone mineral density 9 (mouse) Not determined 7 124224043 152509964 Mouse 1301903 Tlsm1_m thymic lymphoma susceptible 1 (mouse) Not determined 7 125760661 152509964 Mouse 1301773 Stheal7_m soft tissue heal 7 (mouse) Not determined 7 126722527 152509964 Mouse 1357880 Brmth6_m behavioral response to methamphetamines 6 (mouse) Not determined 7 126722527 152509964 Mouse 1559008 Lith22_m lithogenic gene 22 (mouse) Not determined 7 126722527 152509964 Mouse 4142010 Myci1_m myocardial infarction 1 (mouse) Not determined 7 132551823 152509964 Mouse 1301195 Mlviq1_m murine leukemia virus infection QTL (mouse) Not determined 7 134795777 152509964 Mouse 1301590 Pbwg3_m postnatal body weight growth 3 (mouse) Not determined 7 134943409 152509964 Mouse 1300566 Sluc8_m susceptibility to lung cancer 8 (mouse) Not determined 7 135030319 152509964 Mouse 1301547 Bgeq6_m body growth early QTL 6 (mouse) Not determined 7 135030319 152509964 Mouse