Timp3 (tissue inhibitor of metalloproteinase 3) - Rat Genome Database

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Gene: Timp3 (tissue inhibitor of metalloproteinase 3) Mus musculus
Analyze
Symbol: Timp3
Name: tissue inhibitor of metalloproteinase 3
RGD ID: 11419
MGI Page MGI
Description: Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Acts upstream of or within cellular response to organic substance. Located in basement membrane. Is expressed in several structures, including alimentary system; central nervous system; eye posterior segment; genitourinary system; and musculoskeletal system. Used to study Sorsby's fundus dystrophy and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: metalloproteinase inhibitor 3; Timp; Timp-3; tissue inhibitor of metalloproteinases 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391086,136,276 - 86,185,369 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1086,136,236 - 86,185,370 (+)EnsemblGRCm39 Ensembl
GRCm381086,300,412 - 86,349,505 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1086,300,372 - 86,349,506 (+)EnsemblGRCm38mm10GRCm38
MGSCv371085,763,157 - 85,812,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361085,730,336 - 85,779,305 (+)NCBIMGSCv36mm8
Celera1088,278,411 - 88,327,541 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1042.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-fluorouracil  (ISO)
acetamide  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
amosite asbestos  (EXP)
ancitabine  (ISO)
aniline  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
candesartan  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
chondroitin sulfate  (ISO)
chromium atom  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
fenamidone  (EXP)
fenhexamid  (ISO)
floxuridine  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glyphosate  (ISO)
graphite  (ISO)
heparan sulfate  (ISO)
hydrogen cyanide  (EXP)
hydroquinone  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
inulin  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
linuron  (ISO)
malathion  (ISO)
medroxyprogesterone acetate  (ISO)
metformin  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (EXP)
naproxen  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nitrofen  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion-methyl  (ISO)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
Phenelzine  (EXP)
phenylmercury acetate  (ISO)
PhIP  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium cyanide  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
prostaglandin F2alpha  (ISO)
quinoline  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
rofecoxib  (ISO)
rotenone  (EXP)
Salinomycin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sorafenib  (EXP)
succimer  (ISO)
sulfasalazine  (EXP)
sulindac  (ISO)
sumatriptan  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP)
tanespimycin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abdominal aorta aneurysm  (IAGP)
abnormal abdominal aorta morphology  (IAGP)
abnormal aorta morphology  (IAGP)
abnormal aorta wall morphology  (IAGP)
abnormal apoptosis  (IAGP)
abnormal artery morphology  (IAGP)
abnormal blood vessel elastic tissue morphology  (IAGP)
abnormal blood vessel physiology  (IAGP)
abnormal branching involved in terminal bronchiole morphogenesis  (IAGP)
abnormal bronchiole morphology  (IAGP)
abnormal Bruch membrane morphology  (IAGP)
abnormal cardiac muscle relaxation  (IAGP)
abnormal choroid vasculature morphology  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal involution of the mammary gland  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lactation  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal liver lobule morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal pulmonary alveolus wall morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal retina blood vessel morphology  (IEA)
abnormal retina morphology  (IEA)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal spatial learning  (IAGP)
abnormal systemic arterial blood pressure  (IAGP)
abnormal vascular branching morphogenesis  (IAGP)
aortitis  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
congestive heart failure  (IAGP)
decreased body weight  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased left ventricle developed pressure  (IAGP)
decreased left ventricle systolic pressure  (IAGP)
decreased susceptibility to induced hypothermia  (IAGP)
decreased systemic arterial blood pressure  (IAGP)
decreased vasodilation  (IAGP)
decreased ventricle muscle contractility  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated heart left ventricle  (IAGP)
dilated terminal bronchiole tube  (IAGP)
enlarged kidney  (IAGP)
hepatic necrosis  (IAGP)
hunched posture  (IAGP)
hydronephrosis  (IAGP)
impaired liver regeneration  (IAGP)
impaired lung alveolus development  (IAGP)
increased body temperature  (IAGP)
increased carbon dioxide production  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased mean corpuscular volume  (IEA)
increased neutrophil cell number  (IAGP)
increased oxygen consumption  (IAGP)
increased response of heart to induced stress  (IAGP)
increased susceptibility to induced aneurysm formation  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to injury  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
lethargy  (IAGP)
liver inflammation  (IAGP)
overexpanded pulmonary alveolus  (IAGP)
premature death  (IAGP)
pulmonary edema  (IAGP)
respiratory distress  (IAGP)
ruffled hair  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, etal., Genome Res 1997 Nov;7(11):1085-93.
2. Promoter hypermethylation profile of kidney cancer. Dulaimi E, etal., Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):3972-9.
3. Inhibition of diabetic nephropathy by a GH antagonist: a molecular analysis. Esposito C, etal., Kidney Int. 1996 Aug;50(2):506-14.
4. Sorsby fundus dystrophy: reevaluation of variable expressivity in patients carrying a TIMP3 founder mutation. Felbor U, etal., Arch Ophthalmol. 1997 Dec;115(12):1569-71.
5. Evidence for a role of the Simian Virus 40 in human breast carcinomas. Hachana M, etal., Breast Cancer Res Treat. 2008 Jan 18;.
6. mRNA expression of matrix metalloproteases and their inhibitors differs in subtypes of renal cell carcinomas. Hagemann T, etal., Eur J Cancer. 2001 Oct;37(15):1839-46.
7. Tissue inhibitor of metalloproteinases-3 promoter methylation is an independent prognostic factor for bladder cancer. Hoque MO, etal., J Urol. 2008 Feb;179(2):743-7. Epub 2007 Dec 20.
8. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
9. Inhibition of microRNA-222 up-regulates TIMP3 to promotes osteogenic differentiation of MSCs from fracture rats with type 2 diabetes mellitus. Jiang C, etal., J Cell Mol Med. 2020 Jan;24(1):686-694. doi: 10.1111/jcmm.14777. Epub 2019 Nov 6.
10. Zhonghua wai ke za zhi [Chinese journal of surgery] Jiang X, etal., Zhonghua Wai Ke Za Zhi. 2000 Apr;38(4):291-3, 19.
11. Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer. Kotzsch M, etal., Eur J Cancer. 2005 Nov;41(17):2760-8. Epub 2005 Oct 26.
12. Negative correlation of cytoplasm TIMP3 with miR-222 indicates a good prognosis for NSCLC. Lei Y, etal., Onco Targets Ther. 2018 Sep 6;11:5551-5557. doi: 10.2147/OTT.S172522. eCollection 2018.
13. Immunohistochemical changes in vulnerable rat brain regions after reversible global brain ischaemia. Martinez G, etal., J Mol Histol. 2007 Aug;38(4):295-302. Epub 2007 Jun 6.
14. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. MGD IEA MGD IEA
17. Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans. Monroy A, etal., Diabetologia. 2009 Jul 25.
18. Expression of tissue inhibitor of matrix metalloproteinases (TIMP)-3 protein in invasive breast carcinoma: relation to tumor phenotype and clinical outcome. Mylona E, etal., Breast Cancer Res. 2006;8(5):R57.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. ADAM-17 and TIMP3 protein and mRNA expression in spinal cord white matter of rats with acute experimental autoimmune encephalomyelitis. Plumb J, etal., J Neuroimmunol. 2005 Jul;164(1-2):1-9.
21. Mouse MP Annotation Import Pipeline RGD automated import pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues. Riddick AC, etal., Br J Cancer. 2005 Jun 20;92(12):2171-80.
25. Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinase-3 and -4 in normal ovary and ovarian carcinoma. Ripley D, etal., Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1794-800.
26. An ATIPical family of angiotensin II AT2 receptor-interacting proteins. Rodrigues-Ferreira S and Nahmias C, Trends Endocrinol Metab. 2010 Nov;21(11):684-90.
27. Matrix metalloproteinases and their natural inhibitors in fibrovascular membranes of proliferative diabetic retinopathy. Salzmann J, etal., Br J Ophthalmol. 2000 Oct;84(10):1091-6.
28. Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinases TIMP-3 and -4 in benign endometrium and endometrial cancer. Tunuguntla R, etal., Gynecol Oncol. 2003 Jun;89(3):453-9.
29. [Effects of glutamine on matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-3 expressions in myocardium of rats with sepsis] Wang H, etal., Zhonghua Er Ke Za Zhi. 2006 Aug;44(8):587-91.
30. Assessment of gene promoter hypermethylation for detection of cervical neoplasia. Wisman GB, etal., Int J Cancer. 2006 Oct 15;119(8):1908-14.
31. Suppression subtractive hybridization identified differentially expressed genes in lung adenocarcinoma: ERGIC3 as a novel lung cancer-related gene. Wu M, etal., BMC Cancer. 2013 Feb 1;13:44. doi: 10.1186/1471-2407-13-44.
32. Promoter hypermethylation of multiple genes in hydatidiform mole and choriocarcinoma. Xue WC, etal., J Mol Diagn. 2004 Nov;6(4):326-34.
33. Distribution and expression of tissue inhibitors of metalloproteinase in dorsal root entry zone and dorsal column after dorsal root injury. Zhang X, etal., J Neurosci Res. 2006 Aug 1;84(2):278-90.
34. Adenovirus carrying TIMP-3: a potential tool for cervical cancer treatment. Zhang Y, etal., Gynecol Oncol. 2008 Jan;108(1):234-40. Epub 2007 Oct 31.
35. MiR-21 and miR-222 inhibit apoptosis of adult dorsal root ganglion neurons by repressing TIMP3 following sciatic nerve injury. Zhou S, etal., Neurosci Lett. 2015 Jan 23;586:43-9. doi: 10.1016/j.neulet.2014.12.006. Epub 2014 Dec 4.
Additional References at PubMed
PMID:7626795   PMID:7642607   PMID:7743917   PMID:7782289   PMID:7949367   PMID:8118794   PMID:8132674   PMID:8654952   PMID:8661157   PMID:8674412   PMID:8862765   PMID:8889548  
PMID:8956284   PMID:8985117   PMID:9006089   PMID:9013889   PMID:9108368   PMID:9182717   PMID:9285822   PMID:9291579   PMID:9291583   PMID:9507200   PMID:10022836   PMID:10090151  
PMID:10225966   PMID:10232461   PMID:10341094   PMID:10349636   PMID:10621841   PMID:10706738   PMID:10985432   PMID:11042159   PMID:11052264   PMID:11076861   PMID:11165481   PMID:11172053  
PMID:11217851   PMID:11359935   PMID:11544199   PMID:11560951   PMID:11560952   PMID:11675412   PMID:11869290   PMID:11891916   PMID:11988080   PMID:12147610   PMID:12384438   PMID:12466851  
PMID:12477932   PMID:12652295   PMID:12815621   PMID:12909586   PMID:12950084   PMID:14499643   PMID:14568914   PMID:15063736   PMID:15226823   PMID:15262835   PMID:15322543   PMID:15489334  
PMID:15556938   PMID:15609325   PMID:15761851   PMID:15805139   PMID:15920158   PMID:15949468   PMID:16037568   PMID:16113801   PMID:16141072   PMID:16141073   PMID:16294222   PMID:16393953  
PMID:16418837   PMID:16469749   PMID:16602821   PMID:16702949   PMID:16778336   PMID:16890932   PMID:17030988   PMID:17122142   PMID:17327279   PMID:17328064   PMID:17342361   PMID:17454105  
PMID:17586692   PMID:17602244   PMID:17664861   PMID:17673693   PMID:17945252   PMID:17962815   PMID:18006877   PMID:18267097   PMID:18295466   PMID:18408187   PMID:18554416   PMID:18559979  
PMID:18639653   PMID:18802027   PMID:19027012   PMID:19066089   PMID:19111539   PMID:19128402   PMID:19211917   PMID:19339693   PMID:19406980   PMID:19463158   PMID:19478078   PMID:19625257  
PMID:19806081   PMID:19877183   PMID:19933155   PMID:20008147   PMID:20056610   PMID:20628198   PMID:20675565   PMID:20682640   PMID:20798233   PMID:20980382   PMID:21135503   PMID:21243368  
PMID:21267068   PMID:21282576   PMID:21421844   PMID:21731608   PMID:21871134   PMID:21873635   PMID:21900081   PMID:22014525   PMID:22015660   PMID:22053204   PMID:22228717   PMID:22323541  
PMID:22383695   PMID:22896043   PMID:23095891   PMID:23144462   PMID:23299479   PMID:23401241   PMID:23524300   PMID:23742180   PMID:23760282   PMID:23797704   PMID:23806407   PMID:24006456  
PMID:24154525   PMID:24194600   PMID:24373743   PMID:24574341   PMID:24692173   PMID:24736588   PMID:24812324   PMID:24943223   PMID:25150980   PMID:25193593   PMID:25347747   PMID:25572963  
PMID:25636537   PMID:25706237   PMID:25805621   PMID:25807548   PMID:25920569   PMID:25964075   PMID:26299440   PMID:26332574   PMID:26500845   PMID:26527864   PMID:26648042   PMID:26993226  
PMID:27373162   PMID:27476853   PMID:27519049   PMID:27621061   PMID:27626380   PMID:27694478   PMID:27756793   PMID:27821617   PMID:28002442   PMID:28236102   PMID:28378742   PMID:28535371  
PMID:28700664   PMID:28751722   PMID:29134286   PMID:29373036   PMID:29456135   PMID:29791855   PMID:30559277   PMID:30572657   PMID:30594674   PMID:30670377   PMID:30822518   PMID:31292722  
PMID:31371388   PMID:32309847   PMID:32518385   PMID:32828705   PMID:32896839   PMID:33153107   PMID:33604775   PMID:33763067   PMID:34321999   PMID:35831953   PMID:37325923   PMID:37456993  
PMID:37844423   PMID:38313841   PMID:38369214   PMID:38374152  


Genomics

Comparative Map Data
Timp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391086,136,276 - 86,185,369 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1086,136,236 - 86,185,370 (+)EnsemblGRCm39 Ensembl
GRCm381086,300,412 - 86,349,505 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1086,300,372 - 86,349,506 (+)EnsemblGRCm38mm10GRCm38
MGSCv371085,763,157 - 85,812,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361085,730,336 - 85,779,305 (+)NCBIMGSCv36mm8
Celera1088,278,411 - 88,327,541 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1042.83NCBI
TIMP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382232,801,705 - 32,863,041 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2232,801,705 - 32,863,041 (+)EnsemblGRCh38hg38GRCh38
GRCh372233,197,691 - 33,259,028 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,526,802 - 31,589,028 (+)NCBINCBI36Build 36hg18NCBI36
Build 342231,521,361 - 31,583,581NCBI
Celera2216,999,013 - 17,061,296 (+)NCBICelera
Cytogenetic Map22q12.3ENTREZGENE
HuRef2216,154,700 - 16,216,984 (+)NCBIHuRef
CHM1_12233,156,307 - 33,218,500 (+)NCBICHM1_1
T2T-CHM13v2.02233,266,136 - 33,327,517 (+)NCBIT2T-CHM13v2.0
Timp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8719,408,539 - 19,459,558 (-)NCBIGRCr8
mRatBN7.2717,520,827 - 17,571,850 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl717,521,919 - 17,571,839 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx719,480,687 - 19,531,680 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0721,639,451 - 21,690,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0721,420,352 - 21,471,347 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0723,543,125 - 23,594,170 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl723,544,215 - 23,594,133 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0723,693,364 - 23,744,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4719,677,144 - 19,727,072 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1719,686,693 - 19,737,062 (-)NCBI
Celera714,761,240 - 14,810,915 (-)NCBICelera
Cytogenetic Map7q13NCBI
Timp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540541,613,966 - 41,655,813 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540541,613,976 - 41,655,813 (+)NCBIChiLan1.0ChiLan1.0
TIMP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22342,741,534 - 42,803,142 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12245,441,873 - 45,503,391 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02213,811,297 - 13,872,799 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12231,662,567 - 31,721,500 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2231,662,562 - 31,723,964 (+)Ensemblpanpan1.1panPan2
TIMP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11030,627,154 - 30,681,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1030,627,154 - 30,694,288 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1030,610,166 - 30,664,261 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01031,469,330 - 31,523,514 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1031,465,801 - 31,536,528 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11031,209,878 - 31,264,020 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01031,499,587 - 31,553,699 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01031,684,823 - 31,738,972 (-)NCBIUU_Cfam_GSD_1.0
Timp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494513,986,214 - 14,035,739 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364926,996,613 - 7,046,190 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364926,996,627 - 7,046,137 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl512,185,818 - 12,242,581 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1512,185,816 - 12,242,599 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2511,962,119 - 12,019,214 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIMP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11915,621,609 - 15,684,118 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1915,622,431 - 15,680,449 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045110,320,510 - 110,382,442 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247501,775,744 - 1,817,385 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247501,776,197 - 1,817,279 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Timp3
1624 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1907
Count of miRNA genes:749
Interacting mature miRNAs:1004
Transcripts:ENSMUST00000020234, ENSMUST00000132307, ENSMUST00000136045, ENSMUST00000151134
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse
14747004Mancz8_mmandible centroid size 8 (mouse)1082078412116078412Mouse
11059554Lmr32e_mleishmaniasis resistance 32e (mouse)1082309418116309657Mouse
11059555Lmr32f_mleishmaniasis resistance 32f (mouse)1082309418116309657Mouse
11059550Lmr32a_mleishmaniasis resistance 32a (mouse)1082309418116309657Mouse
11059551Lmr32b_mleishmaniasis resistance 32b (mouse)1082309418116309657Mouse
11059553Lmr32d_mleishmaniasis resistance 32d (mouse)1082309418116309657Mouse
1301165Lith7_mlithogenic gene 7 (mouse)Not determined1082309418116309657Mouse
10043881Adip24_madiposity 24 (mouse)Not determined1082392803116392952Mouse
4141382Ssrq4_mstress response QTL 4 (mouse)Not determined8249093890856102Mouse
12910789Pwgrq19_mpost-weaning growth rate QTL 19 (mouse)108282870092169056Mouse
4141054mwfh_mmodifier of white forlock hypopigmentation (mouse)Not determined83017003117017136Mouse
1357594Estoq3_membryo survival total QTL 3 (mouse)Not determined1084079650122041528Mouse
1357622Espq3_membryo survival preimplantation QTL 3 (mouse)Not determined1084079650122041528Mouse
4141479W10q8_mweight 10 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
4142496W6q8_mweight 6 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
4141387Lgaq5_mlate growth adjusted QTL 5 (mouse)Not determined84079650122041528Mouse
4142365Egq9_mearly growth QTL 9 (mouse)Not determined84079650122041528Mouse
1357779Tesq3_mtestis weight QTL 3 (mouse)Not determined1084079650122041528Mouse
14700795Mencq7_mmeniscus calcification QTL 7 (mouse)108531386486647864Mouse
1357638Cia29_mcollagen induced arthritis 29 (mouse)Not determined1085454982118497353Mouse

Markers in Region
RH128273  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381086,346,767 - 86,346,986UniSTSGRCm38
MGSCv371085,809,512 - 85,809,731UniSTSGRCm37
Celera1088,324,809 - 88,325,028UniSTS
Cytogenetic Map10C1-D1UniSTS
Cytogenetic Map10C2UniSTS
RH129267  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381086,346,758 - 86,346,949UniSTSGRCm38
MGSCv371085,809,503 - 85,809,694UniSTSGRCm37
Celera1088,324,800 - 88,324,991UniSTS
Cytogenetic Map10C1-D1UniSTS
Cytogenetic Map10C2UniSTS
Timp3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381086,345,867 - 86,346,348UniSTSGRCm38
MGSCv371085,808,612 - 85,809,093UniSTSGRCm37
Celera1088,323,908 - 88,324,390UniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map10C1-D1UniSTS
cM Map1047.0UniSTS
cM Map1047.0UniSTS
Timp3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C1-D1UniSTS
cM Map1047.0UniSTS
Timp3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381086,345,921 - 86,346,172UniSTSGRCm38
MGSCv371085,808,666 - 85,808,917UniSTSGRCm37
Celera1088,323,962 - 88,324,213UniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map10C1-D1UniSTS
cM Map1047.0UniSTS
Timp3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C1-D1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB041611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC125060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC145076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK128943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY622855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE651900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY439696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L27424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U19462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z30970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z31358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000020234   ⟹   ENSMUSP00000020234
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1086,136,236 - 86,185,370 (+)Ensembl
GRCm38.p6 Ensembl1086,300,372 - 86,349,506 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132307   ⟹   ENSMUSP00000133236
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1086,138,718 - 86,179,845 (+)Ensembl
GRCm38.p6 Ensembl1086,302,854 - 86,343,981 (+)Ensembl
RefSeq Acc Id: ENSMUST00000136045
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1086,136,420 - 86,162,698 (+)Ensembl
GRCm38.p6 Ensembl1086,300,556 - 86,326,834 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151134
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1086,136,418 - 86,142,645 (+)Ensembl
GRCm38.p6 Ensembl1086,300,554 - 86,306,781 (+)Ensembl
RefSeq Acc Id: NM_011595   ⟹   NP_035725
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391086,136,276 - 86,185,369 (+)NCBI
GRCm381086,300,412 - 86,349,505 (+)ENTREZGENE
MGSCv371085,763,157 - 85,812,250 (+)RGD
Celera1088,278,411 - 88,327,541 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035725   ⟸   NM_011595
- Peptide Label: precursor
- UniProtKB: Q91WL9 (UniProtKB/Swiss-Prot),   P39876 (UniProtKB/Swiss-Prot),   Q54AE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000133236   ⟸   ENSMUST00000132307
RefSeq Acc Id: ENSMUSP00000020234   ⟸   ENSMUST00000020234
Protein Domains
NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P39876-F1-model_v2 AlphaFold P39876 1-211 view protein structure

Promoters
RGD ID:6820013
Promoter ID:MM_KWN:5202
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000050178,   OTTMUST00000050179,   OTTMUST00000050180
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361085,763,216 - 85,763,716 (+)MPROMDB
RGD ID:6820017
Promoter ID:MM_KWN:5203
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000050181
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361085,765,021 - 85,765,902 (+)MPROMDB
RGD ID:8672938
Promoter ID:EPDNEW_M14500
Type:multiple initiation site
Name:Timp3_1
Description:Mus musculus tissue inhibitor of metalloproteinase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381086,300,555 - 86,300,615EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98754 AgrOrtholog
Ensembl Genes ENSMUSG00000020044 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020234 ENTREZGENE
  ENSMUST00000020234.14 UniProtKB/Swiss-Prot
  ENSMUST00000132307.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Netrin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21859 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98754 ENTREZGENE
NCBI Gene 21859 ENTREZGENE
PANTHER PTHR11844 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11844:SF22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Timp3 PhenoGen
PROSITE NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9QAB2_MOUSE UniProtKB/TrEMBL
  P39876 ENTREZGENE
  Q54AE5 ENTREZGENE, UniProtKB/TrEMBL
  Q6GXA7_MOUSE UniProtKB/TrEMBL
  Q91WL9 ENTREZGENE
  TIMP3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q91WL9 UniProtKB/Swiss-Prot