RGD Reference Report - mRNA expression of matrix metalloproteases and their inhibitors differs in subtypes of renal cell carcinomas. - Rat Genome Database

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mRNA expression of matrix metalloproteases and their inhibitors differs in subtypes of renal cell carcinomas.

Authors: Hagemann, T  Gunawan, B  Schulz, M  Fuzesi, L  Binder, C 
Citation: Hagemann T, etal., Eur J Cancer. 2001 Oct;37(15):1839-46.
RGD ID: 2290421
Pubmed: PMID:11576837   (View Abstract at PubMed)

Altered expression of matrix metalloproteases (MMPs) and their inhibitors, the tissue inhibitors of matrix metalloproteases (TIMPs), has been demonstrated in various tumour tissues. mRNA expression patterns of MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, MMP-12, MMP-14 and TIMP-1, TIMP-2, TIMP-3 and TIMP-4 were evaluated by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) in 30 renal cell carcinomas (RCC), as well as in the surrounding tissues. Expression of the MMPs was significantly stronger in the carcinomas than in non-malignant tissues. High levels were demonstrated particularly in clear cell RCCs (CC-RCC). Except for MMP-1, MMP expression in the papillary RCCs (P-RCC) was, for most MMPs, significantly lower. Expression of the TIMPs in malignant cells of both subtypes was weak, with the exception of TIMP-4 which was strongly expressed in the P-RCCs and downregulated in the CC-RCCs. The latter was correlated with chromosomal loss of 3p, harbouring the TIMP-4 gene locus. In conclusion, deregulated expression of the MMPs and TIMPs in RCCs differs according to histology, grade, size and cytogenetic characteristics, suggesting that MMP and TIMP expression patterns play an important role for the typical histomorphological features of RCC subtypes and their respective biological behaviour.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
clear cell renal cell carcinoma  IEP 2290421 RGD 
clear cell renal cell carcinoma  ISOrgd:13503362290421; 2290421 RGD 
renal cell carcinoma  IEP 2290421; 2290421mRNA:decreased expression:kidneyRGD 
renal cell carcinoma  ISOTIMP3 (Homo sapiens)2290421; 2290421mRNA:decreased expression:kidneyRGD 
renal cell carcinoma  ISOTIMP4 (Homo sapiens)2290421; 2290421mRNA:decreased expression:kidneyRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp12  (matrix metallopeptidase 12)
Timp3  (TIMP metallopeptidase inhibitor 3)
Timp4  (TIMP metallopeptidase inhibitor 4)

Genes (Mus musculus)
Mmp12  (matrix metallopeptidase 12)
Timp3  (tissue inhibitor of metalloproteinase 3)
Timp4  (tissue inhibitor of metalloproteinase 4)

Genes (Homo sapiens)
MMP12  (matrix metallopeptidase 12)
TIMP3  (TIMP metallopeptidase inhibitor 3)
TIMP4  (TIMP metallopeptidase inhibitor 4)


Additional Information