View Ontology Report


Angiotensin II (AgtII), the product of Ace action in the renin-angiotensin pathway, is probably the most potent of the biologically active peptides the system generates. Overall AgtII elicits distinct responses through signaling via receptor type 1 and 2, Agtr1 and Agtr2, respectively. Signaling via receptor type 1 is by far the better understood system. The Agtr1 mediated pathway is involved in vasoconstriction, proliferation, hormone release and fluid homeostasis. The powerful but potentially

Pathway Diagram:

Ariadne Genomics Inc. natriuresis Gnai3 Gnai2 G protein mediated signaling pathway via Galphai family Agtr2 mediated effects anti-proliferative vasodilation anti-inflammatory AgtII independent effects Agtr2 --+> Agtr2 mediated effects G protein independent effects Dusp1 the extracellular signal-regulated Raf/Mek/Erk signaling pathway Agtr2 --+> AgtII independent effects Ptpn6 Agtr2 --+> Ptpn6 Agtr2 Agtr2 --+> Dusp1 Ptpn6 ---| the extracellular signal-regulated Raf/Mek/Erk signaling pathway Dusp1 ---| the extracellular signal-regulated Raf/Mek/Erk signaling pathway Agtr2 ---- Gnai2 Agtr2 ---- Mtus1 Mtus1 Agtr2 ---- other Agtr2 partners other Agtr2 partners renin-angiotensin cascade pathway AgtII Agt ---> AgtII Agt Agtr2 ---- Gnai3 AgtII ---- Agtr2

Genes in Pathway:

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angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1582434
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:1581825
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 JBrowse link 5 152,447,348 152,458,005 RGD:5133679
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:5133675
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:5133679
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:7401256
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:7401256
G Mtus1 microtubule associated scaffold protein 1 JBrowse link 16 54,240,892 54,386,131 RGD:5133679
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 4 157,239,141 157,263,890 RGD:5133675
G Slc9a6 solute carrier family 9 member A6 JBrowse link X 158,979,081 159,045,019 RGD:5133679
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:5133679
G Zbtb16 zinc finger and BTB domain containing 16 JBrowse link 8 52,980,226 53,146,765 RGD:5133679

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Groupother Agtr2 partnersadditional Agtr2 interacting proteins
ProteinAgtIIangiotensin II generated from Agt via the renin-angiotensin pathway

Pathway Gene Annotations

Disease Annotations Associated with Genes in the angiotensin II signaling pathway via AT2 receptor
Disease TermsGene Symbols
Abortion, SpontaneousTimp3
ACTH-Secreting Pituitary AdenomaGnai2
Acute ErythroleukemiaErbb3
Adrenal Cortex NeoplasmsGnai2
AIDS-Associated NephropathyAgtr2
Allanson Pantzar McLeod SyndromeAgt
Alzheimer DiseaseAgt
Amyloid NeuropathiesDusp1
Aneurysm, DissectingAgt
Angina, UnstableAgt
Anti-Glomerular Basement Membrane DiseaseAgt , Dusp1
Aortic AneurysmAgt
Aortic Aneurysm, AbdominalAgt
Aortic CalcificationAgt
Aortic CoarctationAgt
Arrhythmias, CardiacAgt
Arthritis, JuvenileDusp1
AsthmaAgtr2 , Timp3
Atrial FibrillationAgt
Atrioventricular BlockGnai2
Auriculo-condylar syndromeGnai3
Bipolar DisorderAgt
bladder urothelial carcinomaErbb3
BradycardiaAgt , Gnai2
breast cancerErbb3
Breast NeoplasmsAgt , Dusp1 , Erbb3 , Gnai2 , Mtus1 , Timp3
Carcinoma, EndometrioidErbb3
Carcinoma, Intraductal, NoninfiltratingErbb3
Carcinoma, LobularAgtr2
Carcinoma, Renal CellAgtr2 , Timp3
Carcinoma, Squamous CellDusp1
Carcinoma, Transitional CellErbb3
Cardiomyopathy, AlcoholicAgt
Cardiomyopathy, DilatedAgt , Agtr2
Cardiomyopathy, HypertrophicAgt
Cardiovascular AbnormalitiesAgt
Cardiovascular DiseasesAgt
Carotid Artery DiseasesAgt
Carotid Artery InjuriesDusp1
Cerebrovascular DisordersAgt
Chronic Intermittent HypoxiaAgt
Cognition DisordersAgt
ColitisDusp1 , Timp3
Colonic NeoplasmsErbb3 , Mtus1
Colorectal NeoplasmsErbb3
Corneal NeovascularizationAgt
Coronary Artery DiseaseAgt
Crohn DiseaseAgt
Death, SuddenAgt
Depressive Disorder, MajorDusp1
Dermatitis, ContactDusp1
Diabetes Mellitus, ExperimentalAgt , Agtr2 , Dusp1 , Timp3
Diabetes Mellitus, Type 1Dusp1
Diabetes Mellitus, Type 2Agt , Agtr2 , Timp3
Diabetic CardiomyopathiesAgtr2
Diabetic EncephalopathiesDusp1
Diabetic NephropathiesAgt , Agtr2
Diabetic RetinopathyAgt
Disease ProgressionErbb3
Drug OverdoseAgt
Encephalomyelitis, Autoimmune, ExperimentalTimp3
Endometrial NeoplasmsErbb3 , Timp3
Endomyocardial FibrosisAgt
EndotoxemiaAgtr2 , Timp3
Epilepsy, Temporal LobeAgt
Epiretinal MembraneTimp3
Erectile DysfunctionAgt
Erythroleukemia, FamilialErbb3
Eye Diseases, HereditaryTimp3
Fabry DiseaseAgt
Fetal Growth RetardationAgt , Agtr2 , Dusp1
FibrosisAgt , Agtr2
Fundus Dystrophy, Pseudoinflammatory, of SorsbyTimp3
Gallbladder NeoplasmsErbb3
GlomerulonephritisAgt , Agtr2
Glomerulonephritis, IGAAgt , Agtr2
Glomerulosclerosis, Focal SegmentalAgt , Agtr2
Glucose IntoleranceDusp1
Granulosa Cell TumorGnai2
Granulosa Cell Tumor of the OvaryGnai2
Heart DiseasesAgt
Heart FailureAgt , Agtr2
Heart Valve DiseasesPtpn6
Hepatitis, AlcoholicAgt
Hernia, DiaphragmaticAgt
Hernias, Diaphragmatic, CongenitalAgtr2
Huntington DiseaseDusp1
HyperalgesiaAgt , Dusp1
HypertensionAgt , Agtr2 , Dusp1
Hypertension, EssentialAgt
Hypertension, MalignantAgt
Hypertension, PortalDusp1
Hypertension, Pregnancy-InducedAgt
Hypertension, PulmonaryAgt
Hypertension, RenalAgt
Hypertension, RenovascularAgtr2
Hypertensive NephropathyAgt
Hypertrophy, Left VentricularAgt , Agtr2 , Dusp1
Hypoxia-Ischemia, BrainAgtr2
Infarction, Middle Cerebral ArteryAgt
InflammationAgt , Agtr2
Inflammatory Bowel DiseasesAgt
Insulin ResistanceAgtr2
Intellectual DisabilityAgtr2 , Cnksr1 , Slc9a6
Ischemic Attack, TransientAgt , Dusp1
Kidney DiseasesAgt
Kidney Failure, ChronicAgt , Agtr2
Kidney NeoplasmsTimp3
Lethal Congenital Contracture Syndrome 2Erbb3
Leukemia, Erythroblastic, AcuteErbb3
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveAgt
Leukemia, Promyelocytic, AcuteZbtb16
Liver CirrhosisAgt
Liver Cirrhosis, BiliaryAgt
Liver Cirrhosis, ExperimentalAgt , Gnai2
Liver DiseasesTimp3
Lung NeoplasmsErbb3
Lupus Erythematosus, SystemicAgtr2
Lymphatic MetastasisErbb3 , Timp3
Macular DegenerationTimp3
Mammary Neoplasms, AnimalGnai2
Mammary Neoplasms, ExperimentalAgt , Agtr2 , Dusp1 , Erbb3 , Gnai2
Meconium Aspiration SyndromeAgt , Agtr2
Median NeuropathyErbb3
Melanoma, Cutaneous MalignantAgt
Mental Retardation, X-LinkedAgtr2
Mental Retardation, X-Linked, Syndromic, Christianson TypeSlc9a6
Metabolic Syndrome XAgt
Mitral Valve ProlapseAgt
Mouth NeoplasmsErbb3
Multiple SclerosisAgt
Myocardial InfarctionAgt
Myocardial IschemiaAgt , Dusp1
Myocardial Reperfusion InjuryAgt
Nasopharyngeal CarcinomaErbb3
Neoplasm InvasivenessTimp3 , Zbtb16
Neoplasm MetastasisAgtr2 , Erbb3
Neoplasm Recurrence, LocalGnai2
Nephrosis, Puromycin AminonucleosideAgt
Neurotoxicity SyndromesTimp3
ObesityAgt , Agtr2 , Dusp1
Otitis MediaDusp1
Ovarian CystsAgtr2
Ovarian NeoplasmsDusp1 , Erbb3 , Mtus1 , Timp3
Pancreatic NeoplasmsAgtr2
Peptic Ulcer HemorrhageAgt
Phyllodes TumorErbb3
Pituitary ACTH HypersecretionGnai2
Polycystic Kidney DiseasesAgt
Prediabetic StateAgt
prostate cancerErbb3
Prostatic NeoplasmsDusp1 , Erbb3 , Timp3 , Zbtb16
Pseudoinflammatory Fundus Dystrophy, Finnish TypeTimp3
Pulmonary Disease, Chronic ObstructiveErbb3
Pulmonary EdemaAgt
Pulmonary FibrosisAgt , Agtr2
Purpura, Schoenlein-HenochAgt
Radiation Injuries, ExperimentalAgtr2
Renal InsufficiencyAgt
Renal Insufficiency, ChronicAgtr2
Renal Tubular DysgenesisAgt
Reperfusion InjuryAgt , Agtr2 , Timp3
Respiratory HypersensitivityPtpn6
Retina Reperfusion InjuryDusp1
Retinal VasculitisAgt
Retinopathy of PrematurityAgt
Sciatic NeuropathyAgt
Scleroderma, DiffuseAgt
Scleroderma, SystemicAgt
SeizuresAgt , Dusp1
Sick Sinus SyndromeAgt
Skeletal Defects, Genital Hypoplasia, And Mental RetardationZbtb16
Spinal Cord InjuriesDusp1 , Erbb3
Stomach NeoplasmsAgtr2 , Erbb3 , Timp3
Stomach UlcerAgt
StrokeAgt , Agtr2
Tachycardia, VentricularGnai2
Ureteral ObstructionAgt
Urinary Bladder DiseasesTimp3
Urinary Bladder NeoplasmsDusp1 , Erbb3 , Timp3
Urogenital AbnormalitiesAgtr2
uterine carcinosarcomaErbb3
Uterine Cervical NeoplasmsErbb3 , Timp3
Uterine NeoplasmsErbb3
Vascular RemodelingAgt
Vascular System InjuriesAgtr2
Ventricular Dysfunction, LeftAgt
Ventricular Tachycardia, FamilialGnai2
Vesico-Ureteral RefluxAgtr2
Wallerian DegenerationErbb3 , Timp3
Pathway Annotations Associated with Genes in the angiotensin II signaling pathway via AT2 receptor
Pathway TermsGene Symbols
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein familyGnai2
acute myeloid leukemia pathwayZbtb16
angiotensin (1-7) signaling pathwayAgt
angiotensin II signaling pathwayAgt , Agtr2
angiotensin II signaling pathway via AT1 receptorAgt
angiotensin II signaling pathway via AT2 receptorAgt , Agtr2 , Cnksr1 , Dusp1 , Erbb3 , Gnai2 , Gnai3 , Mtus1 , Ptpn6 , Slc9a6 , Timp3 , Zbtb16
angiotensin III signaling pathwayAgt , Agtr2
angiotensin III signaling pathway via AT1 receptorAgt
angiotensin III signaling pathway via AT2 receptorAgt , Agtr2
angiotensin IV signaling pathwayAgt
angiotensin signaling pathwayAgt
B cell receptor signaling pathwayPtpn6
benazepril pharmacodynamics pathwayAgt
c-Jun N-terminal kinases MAPK signaling pathwayDusp1
calcium/calcium-mediated signaling pathwayErbb3
candesartan pharmacodynamics pathwayAgt
captopril pharmacodynamics pathwayAgt
chemokine mediated signaling pathwayGnai2 , Gnai3
cilazapril pharmacodynamics pathwayAgt
dopamine signaling pathway via D2 family of receptorsGnai2
eicosanoid signaling pathwayGnai2
enalapril pharmacodynamics pathwayAgt
endocytosis pathwayErbb3
endothelin signaling pathwayGnai2 , Gnai3
epidermal growth factor/neuregulin signaling pathwayErbb3 , Gnai3 , Ptpn6
eprosartan pharmacodynamics pathwayAgt
erythropoietin signaling pathwayPtpn6
forasartsn pharmacodynamics pathwayAgt
fosinopril pharmacodynamics pathwayAgt
G protein mediated signaling pathway via Galphai familyAgtr2 , Gnai2 , Gnai3
glutamate signaling pathwayGnai2 , Gnai3
Hedgehog signaling pathwayGnai2 , Gnai3
interleukin-3 signaling pathwayCnksr1
interleukin-4 signaling pathwayPtpn6
irbesartan pharmacodynamics pathwayAgt
Jak-Stat signaling pathwayPtpn6
Leishmania infection pathwayPtpn6
lisinopril pharmacodynamics pathwayAgt
long term depressionGnai2 , Gnai3
long term potentiationAgt
losartan pharmacodynamics pathwayAgt
mitogen activated protein kinase signaling pathwayDusp1
moexipril pharmacodynamics pathwayAgt
myocardial infarction pathwayAgt
olmesartan pharmacodynamics pathwayAgt
p38 MAPK signaling pathwayDusp1
perindopril pharmacodynamics pathwayAgt
quinapril pharmacodynamics pathwayAgt
ramipril pharmacodynamics pathwayAgt
renin-angiotensin cascade pathwayAgt , Agtr2
sphingosine 1-phosphate signaling pathwayGnai2 , Gnai3
spirapril pharmacodynamics pathwayAgt
T cell receptor signaling pathwayPtpn6
telmisartan pharmacodynamics pathwayAgt
Toxoplasma gondii infection pathwayGnai2 , Gnai3
trandolapril pharmacodynamics pathwayAgt
Trypanosoma cruzi infection pathwayGnai2 , Gnai3
valsartan pharmacodynamics pathwayAgt
vascular endothelial growth factor signaling pathwayPtpn6
Phenotype Annotations Associated with Genes in the angiotensin II signaling pathway via AT2 receptor
Phenotype TermsGene Symbols
cardiac hypertrophyAgtr2

References Associated with the angiotensin II signaling pathway via AT2 receptor:

Ontology Path Diagram:

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