TIMP3 (TIMP metallopeptidase inhibitor 3) - Rat Genome Database

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Gene: TIMP3 (TIMP metallopeptidase inhibitor 3) Chlorocebus sabaeus
Analyze
Symbol: TIMP3
Name: TIMP metallopeptidase inhibitor 3
RGD ID: 18514110
Description: ENCODES a protein that exhibits metal ion binding (inferred); metalloendopeptidase inhibitor activity (inferred); peptidase inhibitor activity (inferred); INVOLVED IN cellular response to hypoxia (ortholog); cellular response to interleukin-6 (ortholog); cellular response to organic substance (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; ASSOCIATED WITH arteriovenous malformations of the brain (ortholog); asthma (ortholog); bladder disease (ortholog); FOUND IN basement membrane (inferred); extracellular matrix (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: metalloproteinase inhibitor 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11915,621,609 - 15,684,118 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1915,622,431 - 15,680,449 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045110,320,510 - 110,382,442 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TIMP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11915,621,609 - 15,684,118 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1915,622,431 - 15,680,449 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045110,320,510 - 110,382,442 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TIMP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382232,801,705 - 32,863,041 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2232,801,705 - 32,863,041 (+)EnsemblGRCh38hg38GRCh38
GRCh372233,197,691 - 33,259,028 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,526,802 - 31,589,028 (+)NCBINCBI36Build 36hg18NCBI36
Build 342231,521,361 - 31,583,581NCBI
Celera2216,999,013 - 17,061,296 (+)NCBICelera
Cytogenetic Map22q12.3ENTREZGENE
HuRef2216,154,700 - 16,216,984 (+)NCBIHuRef
CHM1_12233,156,307 - 33,218,500 (+)NCBICHM1_1
T2T-CHM13v2.02233,266,136 - 33,327,517 (+)NCBIT2T-CHM13v2.0
Timp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391086,136,276 - 86,185,369 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1086,136,236 - 86,185,370 (+)EnsemblGRCm39 Ensembl
GRCm381086,300,412 - 86,349,505 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1086,300,372 - 86,349,506 (+)EnsemblGRCm38mm10GRCm38
MGSCv371085,763,157 - 85,812,250 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361085,730,336 - 85,779,305 (+)NCBIMGSCv36mm8
Celera1088,278,411 - 88,327,541 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1042.83NCBI
Timp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8719,408,539 - 19,459,558 (-)NCBIGRCr8
mRatBN7.2717,520,827 - 17,571,850 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl717,521,919 - 17,571,839 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx719,480,687 - 19,531,680 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0721,639,451 - 21,690,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0721,420,352 - 21,471,347 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0723,543,125 - 23,594,170 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl723,544,215 - 23,594,133 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0723,693,364 - 23,744,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4719,677,144 - 19,727,072 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1719,686,693 - 19,737,062 (-)NCBI
Celera714,761,240 - 14,810,915 (-)NCBICelera
Cytogenetic Map7q13NCBI
Timp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540541,613,966 - 41,655,813 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540541,613,976 - 41,655,813 (+)NCBIChiLan1.0ChiLan1.0
TIMP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22342,741,534 - 42,803,142 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12245,441,873 - 45,503,391 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02213,811,297 - 13,872,799 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12231,662,567 - 31,721,500 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2231,662,562 - 31,723,964 (+)Ensemblpanpan1.1panPan2
TIMP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11030,627,154 - 30,681,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1030,627,154 - 30,694,288 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1030,610,166 - 30,664,261 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01031,469,330 - 31,523,514 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1031,465,801 - 31,536,528 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11031,209,878 - 31,264,020 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01031,499,587 - 31,553,699 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01031,684,823 - 31,738,972 (-)NCBIUU_Cfam_GSD_1.0
Timp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494513,986,214 - 14,035,739 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364926,996,613 - 7,046,190 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364926,996,627 - 7,046,137 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl512,185,818 - 12,242,581 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1512,185,816 - 12,242,599 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2511,962,119 - 12,019,214 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Timp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247501,775,744 - 1,817,385 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247501,776,197 - 1,817,279 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 60
Low 13
Below cutoff 4

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007975578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000006293   ⟹   ENSCSAP00000004500
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1915,622,431 - 15,680,449 (+)Ensembl
RefSeq Acc Id: XM_007975578   ⟹   XP_007973769
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11915,621,609 - 15,684,118 (+)NCBI
Vero_WHO_p1.0NW_023666045110,320,510 - 110,382,442 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007973769 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000004500
  ENSCSAP00000004500.1
Reference Protein Sequences
RefSeq Acc Id: XP_007973769   ⟸   XM_007975578
- UniProtKB: A0A0D9R7B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000004500   ⟸   ENSCSAT00000006293


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008241 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006293.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/TrEMBL
  3.90.370.10 UniProtKB/TrEMBL
InterPro Netrin_domain UniProtKB/TrEMBL
  TIMP UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
  TIMP_C UniProtKB/TrEMBL
  TIMP_CS UniProtKB/TrEMBL
KEGG Report csab:103223216 UniProtKB/TrEMBL
NCBI Gene TIMP3 ENTREZGENE
PANTHER PTHR11844 UniProtKB/TrEMBL
  PTHR11844:SF22 UniProtKB/TrEMBL
Pfam TIMP UniProtKB/TrEMBL
PROSITE NTR UniProtKB/TrEMBL
  TIMP UniProtKB/TrEMBL
SMART NTR UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/TrEMBL
UniProt A0A0D9R7B1 ENTREZGENE, UniProtKB/TrEMBL