Id2 (inhibitor of DNA binding 2) - Rat Genome Database

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Gene: Id2 (inhibitor of DNA binding 2) Mus musculus

Symbol:

Id2

Name:

inhibitor of DNA binding 2

Description:

ENCODES a protein that exhibits ion channel binding (ortholog); INVOLVED IN adipose tissue development; bundle of His development; cell development; PARTICIPATES IN hypoxia inducible factor pathway; transforming growth factor-beta superfamily mediated signaling pathway; ASSOCIATED WITH Vascular System Injuries (ortholog); FOUND IN cytoplasm; nucleus; protein complex; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

AI255428; bHLHb26; C78922; DNA-binding protein inhibitor ID-2; Idb2; inhibitor of differentiation 2

Orthologs:

Homo sapiens : ID2 (inhibitor of DNA binding 2, dominant negative helix-loop-helix protein) HGNC
Rattus norvegicus : Id2 (inhibitor of DNA binding 2)

Latest Assembly:

Mouse Genome Assembly Build 37

Position:

Map	Chr	Position	Strand	Source
Mouse Genome Assembly GRCm38	12	25,093,799 - 25,096,092	-	NCBI
Mouse cM Map	12	8.57		NCBI
Mouse Celera Assembly	12	26,550,909 - 26,553,204	-	NCBI
Mouse Genome Assembly Build 37	12	25,778,664 - 25,780,957	-	NCBI
Mouse Genome Assembly Build 36.1	12	25,778,664 - 25,780,933	-	NCBI
Mouse Cytogenetic Map	12	B		NCBI

Model

Launch Genome Browser (GBrowse)

Annotation (Toggle Detail/Summary View)

Disease Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Vascular System Injuries		ISS	RGD:2859	619536	protein:increased expression:carotid artery, blood vessel wall (rat)	RGD

Gene-Chemical Interaction Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
(-)-epigallocatechin 3-gallate	decreases expression	ISO	RGD:732001	6480464	epigallocatechin gallate results in decreased expression of ID2 mRNA	CTD	PMID:16084531
1-chloro-2,4-dinitrobenzene	increases expression	ISO	RGD:732001	6480464	Dinitrochlorobenzene results in increased expression of ID2 mRNA	CTD	PMID:20146380
17alpha-ethynylestradiol	decreases expression	EXP		6480464	Ethinyl Estradiol results in decreased expression of ID2 mRNA	CTD	PMID:17942748 PMID:17555576
17alpha-ethynylestradiol	decreases expression	ISO	RGD:2859	6480464	Ethinyl Estradiol results in decreased expression of ID2 mRNA	CTD	PMID:12655037 more ...
17alpha-ethynylestradiol	decreases expression	ISO	RGD:2859	6480464	Ethinyl Estradiol results in decreased expression of ID2 mRNA	CTD	PMID:12655037 more ...
17alpha-ethynylestradiol	decreases expression	EXP		6480464	Ethinyl Estradiol results in decreased expression of ID2 mRNA	CTD	PMID:17555576 PMID:17942748
17alpha-ethynylestradiol	decreases expression	ISO	RGD:2859	6480464	Ethinyl Estradiol results in decreased expression of ID2 mRNA	CTD	PMID:17557909 more ...
17alpha-ethynylestradiol	decreases expression	ISO	RGD:2859	6480464	Ethinyl Estradiol results in decreased expression of ID2 mRNA	CTD	PMID:15834898 more ...
17beta-estradiol	decreases expression	ISO	RGD:732001	6480464	Estradiol results in decreased expression of ID2 mRNA	CTD	PMID:20106945
17beta-estradiol	decreases expression	EXP		6480464	Estradiol results in decreased expression of ID2 mRNA	CTD	PMID:23144751
17beta-estradiol	multiple interactions	ISO	RGD:732001	6480464	[Estradiol binds to ESR2 protein] which results in increased expression of ID2 mRNA	CTD	PMID:20404318
17beta-hydroxy-5alpha-androstan-3-one	increases expression	ISO	RGD:732001	6480464	Dihydrotestosterone results in increased expression of ID2 mRNA	CTD	PMID:16541417
2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:732001	6480464	Tetrachlorodibenzodioxin results in increased expression of ID2 mRNA	CTD	PMID:20106945 PMID:11489354
2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of ID2 mRNA	CTD	PMID:21570461
2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:732001	6480464	Tetrachlorodibenzodioxin results in increased expression of ID2 mRNA	CTD	PMID:11489354 more ...
2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:732001	6480464	Tetrachlorodibenzodioxin results in increased expression of ID2 mRNA	CTD	PMID:11489354 PMID:20106945
2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:2859	6480464	Tetrachlorodibenzodioxin affects the expression of ID2 mRNA	CTD	PMID:22298810
2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of ID2 mRNA	CTD	PMID:17949056
2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of ID2 mRNA	CTD	PMID:19933214
2,4-dinitrotoluene	affects expression	ISO	RGD:2859	6480464	2,4-dinitrotoluene affects the expression of ID2 mRNA	CTD	PMID:21346803
2-amino-2-deoxy-D-glucopyranose	increases expression	EXP		6480464	Glucosamine results in increased expression of ID2 mRNA	CTD	PMID:17178593
2-butoxyethanol	increases expression	EXP		6480464	n-butoxyethanol results in increased expression of ID2 mRNA	CTD	PMID:19812364
2-methoxyethanol	decreases expression	ISO	RGD:2859	6480464	methyl cellosolve results in decreased expression of ID2 mRNA	CTD	PMID:19643169
2-methylcholine	affects expression	ISO	RGD:732001	6480464	beta-methylcholine affects the expression of ID2 mRNA	CTD	PMID:21179406
3-aminobenzamide	decreases expression	ISO	RGD:732001	6480464	3-aminobenzamide results in decreased expression of ID2 mRNA	CTD	PMID:15670817
3-methylcholanthrene	increases expression	EXP		6480464	Methylcholanthrene results in increased expression of ID2 mRNA	CTD	PMID:20713471
5-aza-2'-deoxycytidine	multiple interactions	ISO	RGD:732001	6480464	[decitabine co-treated with vorinostat] affects the expression of ID2 mRNA	CTD	PMID:17330099
5-aza-2'-deoxycytidine	increases expression	ISO	RGD:732001	6480464	decitabine results in increased expression of ID2 mRNA	CTD	PMID:19194470
5-fluorouracil	decreases expression	ISO	RGD:732001	6480464	Fluorouracil results in decreased expression of ID2 protein	CTD	PMID:15352031
5-fluorouracil	multiple interactions	ISO	RGD:732001	6480464	TP53 protein promotes the reaction [Fluorouracil results in increased expression of ID2 mRNA]	CTD	PMID:16557594
5-fluorouracil	affects response to substance	EXP		6480464	ID2 protein affects the susceptibility to Fluorouracil	CTD	PMID:15016739
5-fluorouracil	increases expression	ISO	RGD:732001	6480464	Fluorouracil results in increased expression of ID2 mRNA	CTD	PMID:16557594
5-fluorouracil	affects response to substance	ISO	RGD:732001	6480464	ID2 protein affects the susceptibility to Fluorouracil	CTD	PMID:15352031
acetylsalicylic acid	affects expression	ISO	RGD:2859	6480464	Aspirin affects the expression of ID2 mRNA	CTD	PMID:12800193
aldehydo-D-glucosamine	increases expression	EXP		6480464	Glucosamine results in increased expression of ID2 mRNA	CTD	PMID:17178593
all-trans-retinoic acid	affects expression	ISO	RGD:732001	6480464	Tretinoin affects the expression of ID2 mRNA	CTD	PMID:16054129
all-trans-retinoic acid	multiple interactions	ISO	RGD:732001	6480464	[Tretinoin co-treated with arsenic trioxide] results in increased expression of ID2 mRNA	CTD	PMID:15894607
all-trans-retinoic acid	increases expression	ISO	RGD:732001	6480464	Tretinoin results in increased expression of ID2 mRNA	CTD	PMID:15894607 more ...
all-trans-retinoic acid	increases expression	ISO	RGD:732001	6480464	Tretinoin results in increased expression of ID2 mRNA	CTD	PMID:16129123 more ...
all-trans-retinoic acid	increases expression	ISO	RGD:732001	6480464	Tretinoin results in increased expression of ID2 mRNA	CTD	PMID:17138961 more ...
all-trans-retinoic acid	increases expression	ISO	RGD:732001	6480464	Tretinoin results in increased expression of ID2 mRNA	CTD	PMID:16129123 more ...
all-trans-retinoic acid	increases expression	ISO	RGD:732001	6480464	Tretinoin results in increased expression of ID2 mRNA	CTD	PMID:16129123 more ...
all-trans-retinoic acid	increases expression	ISO	RGD:732001	6480464	Tretinoin results in increased expression of ID2 mRNA	CTD	PMID:17138961 more ...
all-trans-retinoic acid	increases expression	ISO	RGD:732001	6480464	Tretinoin results in increased expression of ID2 mRNA	CTD	PMID:17218384 more ...
all-trans-retinoic acid	decreases expression	ISO	RGD:732001	6480464	Tretinoin results in decreased expression of ID2 mRNA	CTD	PMID:17310985
all-trans-retinoic acid	increases expression	ISO	RGD:732001	6480464	Tretinoin results in increased expression of ID2 mRNA	CTD	PMID:17218384 more ...
ammonium chloride	affects expression	ISO	RGD:2859	6480464	Ammonium Chloride affects the expression of ID2 mRNA	CTD	PMID:16483693
Aroclor 1254	decreases expression	ISO	RGD:732001	6480464	Chlorodiphenyl (54% Chlorine) results in decreased expression of ID2 mRNA	CTD	PMID:16934159
arsenic atom	decreases expression	ISO	RGD:732001	6480464	Arsenic results in decreased expression of ID2 mRNA	CTD	PMID:16835338
benzene	multiple interactions	ISO	RGD:2859	6480464	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of ID2 mRNA	CTD	PMID:17905399
benzo[a]pyrene	decreases expression	EXP		6480464	Benzo(a)pyrene results in decreased expression of ID2 mRNA	CTD	PMID:21569818
benzo[a]pyrene	increases expression	EXP		6480464	Benzo(a)pyrene results in increased expression of ID2 mRNA	CTD	PMID:22228805
beta-D-glucosamine	increases expression	EXP		6480464	Glucosamine results in increased expression of ID2 mRNA	CTD	PMID:17178593
bis(2-ethylhexyl) phthalate	multiple interactions	EXP		6480464	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of ID2 mRNA]	CTD	PMID:19850644
bis(2-ethylhexyl) phthalate	decreases expression	EXP		6480464	Diethylhexyl Phthalate results in decreased expression of ID2 mRNA	CTD	PMID:19850644
bisphenol A	increases expression	ISO	RGD:732001	6480464	bisphenol A results in increased expression of ID2 mRNA	CTD	PMID:22576693
butyric acid	increases expression	ISO	RGD:2859	6480464	Butyric Acid results in increased expression of ID2 mRNA	CTD	PMID:12800193
cadmium dichloride	multiple interactions	ISO	RGD:732001	6480464	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ID2 mRNA	CTD	PMID:12634122
cadmium dichloride	decreases expression	ISO	RGD:2859	6480464	Cadmium Chloride results in decreased expression of ID2 mRNA	CTD	PMID:18636176
calcitriol	decreases expression	ISO	RGD:732001	6480464	Calcitriol results in decreased expression of ID2 mRNA	CTD	PMID:16002434
chloroprene	decreases expression	EXP		6480464	Chloroprene results in decreased expression of ID2 mRNA	CTD	PMID:23125180
chloroprene	increases expression	ISO	RGD:2859	6480464	Chloroprene results in increased expression of ID2 mRNA	CTD	PMID:23125180
choline	multiple interactions	EXP		6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ID2 mRNA	CTD	PMID:20938992
ciguatoxin CTX1B	affects expression	EXP		6480464	Ciguatoxins affects the expression of ID2 mRNA	CTD	PMID:18353800
cisplatin	increases expression	ISO	RGD:732001	6480464	Cisplatin results in increased expression of ID2 mRNA	CTD	PMID:21603599
cisplatin	increases expression	ISO	RGD:732001	6480464	Cisplatin results in increased expression of ID2 mRNA	CTD	PMID:19561079 PMID:21603599
clozapine	increases expression	ISO	RGD:2859	6480464	Clozapine results in increased expression of ID2 mRNA	CTD	PMID:12437575
copper atom	decreases expression	ISO	RGD:2859	6480464	Copper results in decreased expression of ID2 mRNA	CTD	PMID:22465980
copper atom	multiple interactions	EXP		6480464	[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of ID2 mRNA	CTD	PMID:15467011
copper(0)	decreases expression	ISO	RGD:2859	6480464	Copper results in decreased expression of ID2 mRNA	CTD	PMID:22465980
copper(0)	multiple interactions	EXP		6480464	[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of ID2 mRNA	CTD	PMID:15467011
copper(2+) sulfate	increases expression	ISO	RGD:732001	6480464	Copper Sulfate results in increased expression of ID2 mRNA	CTD	PMID:19549813
copper(II) chloride	affects expression	ISO	RGD:732001	6480464	cupric chloride affects the expression of ID2 mRNA	CTD	PMID:17211630
curcumin	decreases expression	ISO	RGD:732001	6480464	Curcumin results in decreased expression of ID2 mRNA	CTD	PMID:21594647
cyclosporin A	decreases expression	ISO	RGD:732001	6480464	Cyclosporine results in decreased expression of ID2 mRNA	CTD	PMID:20106945
cyclosporin A	decreases expression	EXP		6480464	Cyclosporine results in decreased expression of ID2 mRNA	CTD	PMID:19770486
Delta(9)-tetrahydrocannabinol	increases expression	ISO	RGD:732001	6480464	Tetrahydrocannabinol results in increased expression of ID2 mRNA	CTD	PMID:18454173
dexamethasone	decreases expression	ISO	RGD:732001	6480464	Dexamethasone results in decreased expression of ID2 mRNA	CTD	PMID:22048647
diarsenic trioxide	decreases expression	ISO	RGD:732001	6480464	arsenic trioxide results in decreased expression of ID2 mRNA	CTD	PMID:15761015
diarsenic trioxide	increases expression	EXP		6480464	arsenic trioxide results in increased expression of ID2 mRNA	CTD	PMID:21921037
diarsenic trioxide	multiple interactions	ISO	RGD:732001	6480464	[Tretinoin co-treated with arsenic trioxide] results in increased expression of ID2 mRNA	CTD	PMID:15894607
dibenz[a,h]anthracene	increases expression	ISO	RGD:732001	6480464	1,2,5,6-dibenzanthracene results in increased expression of ID2 mRNA	CTD	PMID:16269432
dibenzo[a,l]pyrene	increases expression	ISO	RGD:732001	6480464	dibenzo(a,l)pyrene results in increased expression of ID2 mRNA	CTD	PMID:16269432
dibutyl phthalate	increases expression	EXP		6480464	Dibutyl Phthalate results in increased expression of ID2 mRNA	CTD	PMID:21266533
dichlorine	multiple interactions	ISO	RGD:2859	6480464	[Ozone co-treated with Chlorine] affects the expression of ID2 mRNA	CTD	PMID:18636392
dichlorine	decreases expression	ISO	RGD:2859	6480464	Chlorine results in decreased expression of ID2 mRNA	CTD	PMID:18636392
dichromium trioxide	multiple interactions	ISO	RGD:732001	6480464	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ID2 mRNA	CTD	PMID:12634122
diethylstilbestrol	decreases expression	EXP		6480464	Diethylstilbestrol results in decreased expression of ID2 mRNA	CTD	PMID:21922642
dioxygen	increases expression	ISO	RGD:732001	6480464	Oxygen deficiency results in increased expression of ID2 mRNA	CTD	PMID:17175027
doxorubicin	affects response to substance	ISO	RGD:732001	6480464	ID2 protein affects the susceptibility to Doxorubicin	CTD	PMID:16217747
doxorubicin	affects expression	ISO	RGD:2859	6480464	Doxorubicin affects the expression of ID2 mRNA	CTD	PMID:12187937
elemental selenium	decreases expression	ISO	RGD:732001	6480464	Selenium results in decreased expression of ID2 mRNA	CTD	PMID:19244175
fenofibrate	decreases expression	EXP		6480464	Fenofibrate results in decreased expression of ID2 mRNA	CTD	PMID:11798191
folic acid	multiple interactions	EXP		6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ID2 mRNA	CTD	PMID:20938992
formaldehyde	increases expression	ISO	RGD:732001	6480464	Formaldehyde results in increased expression of ID2 mRNA	CTD	PMID:20655997
haloperidol	decreases expression	ISO	RGD:2859	6480464	Haloperidol results in decreased expression of ID2 mRNA	CTD	PMID:12437575
haloperidol	increases expression	ISO	RGD:2859	6480464	Haloperidol results in increased expression of ID2 mRNA	CTD	PMID:12437575
harmine	multiple interactions	EXP		6480464	Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]	CTD	PMID:20519739
hydrogen chloride	increases expression	ISO	RGD:732001	6480464	Hydrochloric Acid results in increased expression of ID2 mRNA	CTD	PMID:15046208
hydrogen peroxide	affects expression	ISO	RGD:732001	6480464	Hydrogen Peroxide affects the expression of ID2 mRNA	CTD	PMID:20044591
L-methionine	multiple interactions	EXP		6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ID2 mRNA	CTD	PMID:20938992
lead diacetate	multiple interactions	ISO	RGD:732001	6480464	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ID2 mRNA	CTD	PMID:12634122
linalool	increases expression	ISO	RGD:732001	6480464	linalool results in increased expression of ID2 mRNA	CTD	PMID:19922762
manganese atom	increases expression	ISO	RGD:732001	6480464	Manganese results in increased expression of ID2 mRNA	CTD	PMID:17175027
manganese(0)	increases expression	ISO	RGD:732001	6480464	Manganese results in increased expression of ID2 mRNA	CTD	PMID:17175027
manganese(II) chloride	increases expression	ISO	RGD:732001	6480464	manganese chloride results in increased expression of ID2 mRNA	CTD	PMID:17175027
methylmercury(1+)	multiple interactions	ISO	RGD:2859	6480464	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of ID2 mRNA	CTD	PMID:17905399
N-acetyl-L-cysteine	decreases expression	ISO	RGD:732001	6480464	Acetylcysteine results in decreased expression of ID2 mRNA	CTD	PMID:16084531
nickel sulfate	increases expression	ISO	RGD:732001	6480464	nickel sulfate results in increased expression of ID2 mRNA	CTD	PMID:16780908
nickel sulfate	increases expression	ISO	RGD:732001	6480464	nickel sulfate results in increased expression of ID2 mRNA	CTD	PMID:16780908 PMID:20146380
nitroglycerin	increases expression	ISO	RGD:2859	6480464	Nitroglycerin results in increased expression of ID2 mRNA	CTD	PMID:12102619
ozone	multiple interactions	ISO	RGD:2859	6480464	[Ozone co-treated with Chlorine] affects the expression of ID2 mRNA	CTD	PMID:18636392
paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of ID2 mRNA	CTD	PMID:17585979
paracetamol	increases expression	ISO	RGD:732001	6480464	Acetaminophen results in increased expression of ID2 mRNA	CTD	PMID:22230336
paracetamol	affects expression	EXP		6480464	Acetaminophen affects the expression of ID2 mRNA	CTD	PMID:17562736
perfluorooctane-1-sulfonic acid	affects expression	EXP		6480464	perfluorooctane sulfonic acid affects the expression of ID2 mRNA	CTD	PMID:19429403
perfluorooctanoic acid	affects expression	EXP		6480464	perfluorooctanoic acid affects the expression of ID2 mRNA	CTD	PMID:19429403
phenobarbital	multiple interactions	EXP		6480464	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ID2 mRNA]	CTD	PMID:19482888
phenobarbital	decreases expression	ISO	RGD:2859	6480464	Phenobarbital results in decreased expression of ID2 mRNA	CTD	PMID:19162173
phenobarbital	decreases expression	EXP		6480464	Phenobarbital results in decreased expression of ID2 mRNA	CTD	PMID:19482888
pioglitazone	multiple interactions	ISO	RGD:732001	6480464	[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA; more ...	CTD	PMID:20847119
pirinixic acid	multiple interactions	EXP		6480464	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of ID2 mRNA]	CTD	PMID:20059764
pirinixic acid	decreases expression	EXP		6480464	pirinixic acid results in decreased expression of ID2 mRNA	CTD	PMID:11798191 more ...
pirinixic acid	decreases expression	EXP		6480464	pirinixic acid results in decreased expression of ID2 mRNA	CTD	PMID:18445702 more ...
pirinixic acid	decreases expression	EXP		6480464	pirinixic acid results in decreased expression of ID2 mRNA	CTD	PMID:11798191 more ...
pirinixic acid	decreases expression	EXP		6480464	pirinixic acid results in decreased expression of ID2 mRNA	CTD	PMID:20059764 more ...
pirinixic acid	decreases expression	EXP		6480464	pirinixic acid results in decreased expression of ID2 mRNA	CTD	PMID:18445702 more ...
pirinixic acid	decreases expression	EXP		6480464	pirinixic acid results in decreased expression of ID2 mRNA	CTD	PMID:11798191 more ...
pregnenolone 16alpha-carbonitrile	decreases expression	ISO	RGD:2859	6480464	Pregnenolone Carbonitrile results in decreased expression of ID2 mRNA	CTD	PMID:19162173
progesterone	increases expression	ISO	RGD:732001	6480464	Progesterone results in increased expression of ID2 mRNA	CTD	PMID:18037150
propiconazole	decreases expression	EXP		6480464	propiconazole results in decreased expression of ID2 mRNA	CTD	PMID:21278054
prostaglandin F2alpha	decreases expression	ISO	RGD:2859	6480464	Dinoprost results in decreased expression of ID2 mRNA	CTD	PMID:11517196
quercetin	affects expression	ISO	RGD:732001	6480464	Quercetin affects the expression of ID2 mRNA	CTD	PMID:21632981
ranitidine	multiple interactions	ISO	RGD:2859	6480464	Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ID2 mRNA]	CTD	PMID:16415329
rosiglitazone	multiple interactions	ISO	RGD:732001	6480464	[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA; more ...	CTD	PMID:20847119
selenium atom	decreases expression	ISO	RGD:732001	6480464	Selenium results in decreased expression of ID2 mRNA	CTD	PMID:19244175
sevoflurane	affects expression	ISO	RGD:2859	6480464	sevoflurane affects the expression of ID2 mRNA	CTD	PMID:15967596
silicon dioxide	increases expression	EXP		6480464	Silicon Dioxide results in increased expression of ID2 mRNA	CTD	PMID:19073995
tamoxifen	affects expression	EXP		6480464	Tamoxifen affects the expression of ID2 mRNA	CTD	PMID:20937368 PMID:17555576
tamoxifen	affects expression	EXP		6480464	Tamoxifen affects the expression of ID2 mRNA	CTD	PMID:17555576 PMID:20937368
tert-butyl hydroperoxide	increases expression	EXP		6480464	tert-Butylhydroperoxide results in increased expression of ID2 mRNA	CTD	PMID:15003993 PMID:14729362
tert-butyl hydroperoxide	multiple interactions	ISO	RGD:732001	6480464	[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA; more ...	CTD	PMID:20847119
tert-butyl hydroperoxide	increases expression	ISO	RGD:732001	6480464	tert-Butylhydroperoxide results in increased expression of ID2 mRNA	CTD	PMID:20847119
tert-butyl hydroperoxide	increases expression	EXP		6480464	tert-Butylhydroperoxide results in increased expression of ID2 mRNA	CTD	PMID:14729362 PMID:15003993
thioacetamide	decreases expression	ISO	RGD:2859	6480464	Thioacetamide results in decreased expression of ID2 mRNA	CTD	PMID:16297948
trichloroethene	multiple interactions	ISO	RGD:2859	6480464	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of ID2 mRNA	CTD	PMID:17905399
troglitazone	multiple interactions	ISO	RGD:732001	6480464	[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA; more ...	CTD	PMID:20847119
uranium atom	affects expression	ISO	RGD:732001	6480464	Uranium affects the expression of ID2 mRNA	CTD	PMID:15672453
valproic acid	affects expression	EXP		6480464	Valproic Acid affects the expression of ID2 mRNA	CTD	PMID:17292431
valproic acid	increases expression	EXP		6480464	Valproic Acid results in increased expression of ID2 mRNA	CTD	PMID:21427059
valsartan	multiple interactions	ISO	RGD:732001	6480464	valsartan inhibits the reaction [AGT protein results in decreased expression of ID2 mRNA]	CTD	PMID:19225232
vincaleukoblastine	affects response to substance	ISO	RGD:732001	6480464	ID2 protein affects the susceptibility to Vinblastine	CTD	PMID:16217747
zinc atom	multiple interactions	ISO	RGD:732001	6480464	[PCI 5002 co-treated with Zinc] results in increased expression of ID2 mRNA	CTD	PMID:18593933
zinc(0)	multiple interactions	ISO	RGD:732001	6480464	[PCI 5002 co-treated with Zinc] results in increased expression of ID2 mRNA	CTD	PMID:18593933

Gene Ontology Annotations

Biological Process

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
adipose tissue development		IMP	MGI:MGI:3806370	2290270	MGI:MGI:3804739\|PMID:18562627	MGI	MGI:MGI:3804739 PMID:18562627
bundle of His development		IMP	MGI:MGI:2384134	2290270	MGI:MGI:3716040\|PMID:17604724	MGI	MGI:MGI:3716040 PMID:17604724
cell development		IGI	MGI:MGI:98510	2290270	MGI:MGI:3759740\|PMID:17452521	MGI	MGI:MGI:3759740 PMID:17452521
cell maturation		IMP	MGI:MGI:2384134	2290270	MGI:MGI:3759740\|PMID:17452521	MGI	MGI:MGI:3759740 PMID:17452521
cellular response to lithium ion		IDA		2290270	MGI:MGI:3788965\|PMID:18367557	MGI	MGI:MGI:3788965 PMID:18367557
cellular senescence		IMP		2290270	MGI:MGI:4412240\|PMID:18474814	UniProtKB	MGI:MGI:4412240 PMID:18474814
embryonic digestive tract morphogenesis		IDA		2290270	MGI:MGI:4399020\|PMID:16888283	UniProtKB	MGI:MGI:4399020 PMID:16888283
entrainment of circadian clock		IMP	MGI:MGI:3838359	2290270	MGI:MGI:3838062\|PMID:19217292	MGI	MGI:MGI:3838062 PMID:19217292
enucleate erythrocyte differentiation		IGI	MGI:MGI:1857242\|MGI:MGI:2384134	2290270	MGI:MGI:3525032\|PMID:15616565	MGI	MGI:MGI:3525032 PMID:15616565
epithelial cell differentiation involved in mammary gland alveolus development		IMP		2290270	MGI:MGI:2446740\|PMID:12456807	UniProtKB	MGI:MGI:2446740 PMID:12456807
heart development		IGI	MGI:MGI:2679939\|MGI:MGI:2679967	2290270	MGI:MGI:3055698\|PMID:15472070	MGI	MGI:MGI:3055698 PMID:15472070
leukocyte differentiation		IMP	MGI:MGI:2384134	2290270	MGI:MGI:3616749\|PMID:12532109	MGI	MGI:MGI:3616749 PMID:12532109
lymph node development		TAS		2290270	MGI:MGI:1353335\|PMID:10687308	MGI	MGI:MGI:1353335 PMID:10687308
mammary gland alveolus development		IMP		2290270	MGI:MGI:2446740\|PMID:12456807	UniProtKB	MGI:MGI:2446740 PMID:12456807
mammary gland epithelial cell proliferation		IMP		2290270	MGI:MGI:2446740\|PMID:12456807	UniProtKB	MGI:MGI:2446740 PMID:12456807
metanephros development		IMP	MGI:MGI:2384134	2290270	MGI:MGI:3603100\|PMID:15569159	MGI	MGI:MGI:3603100 PMID:15569159
multicellular organismal development		IEA	UniProtKB-KW:KW-0217	2290270	MGI:MGI:1354194	UniProtKB	MGI:MGI:1354194
natural killer cell differentiation		IMP	MGI:MGI:2384134	2290270	MGI:MGI:3759740\|PMID:17452521	MGI	MGI:MGI:3759740 PMID:17452521
natural killer cell differentiation		IGI	MGI:MGI:98510	2290270	MGI:MGI:3759740\|PMID:17452521	MGI	MGI:MGI:3759740 PMID:17452521
negative regulation of B cell differentiation		IMP	MGI:MGI:2384134	2290270	MGI:MGI:3805135\|PMID:18523151	MGI	MGI:MGI:3805135 PMID:18523151
negative regulation of DNA binding		IDA		2290270	MGI:MGI:66136\|PMID:1922066	MGI	MGI:MGI:66136 PMID:1922066
negative regulation of gene expression		IMP		2290270	MGI:MGI:4412240\|PMID:18474814	UniProtKB	MGI:MGI:4412240 PMID:18474814
negative regulation of gene expression		ISO	UniProtKB:P41137	2290270	MGI:MGI:4417868	RGD	MGI:MGI:4417868
negative regulation of neural precursor cell proliferation		IMP		2290270	MGI:MGI:4821067\|PMID:17681138	UniProtKB	MGI:MGI:4821067 PMID:17681138
negative regulation of neuron differentiation		IMP	MGI:MGI:3830733	2290270	MGI:MGI:3829299\|PMID:19109490	MGI	MGI:MGI:3829299 PMID:19109490
negative regulation of neuron differentiation		IMP		2290270	MGI:MGI:4821067\|PMID:17681138	UniProtKB	MGI:MGI:4821067 PMID:17681138
negative regulation of oligodendrocyte differentiation		IMP	MGI:MGI:2384134	2290270	MGI:MGI:3621671\|PMID:11301021	MGI	MGI:MGI:3621671 PMID:11301021
negative regulation of osteoblast differentiation		IGI	MGI:MGI:1321394	2290270	MGI:MGI:3050908\|PMID:15246553	MGI	MGI:MGI:3050908 PMID:15246553
negative regulation of sequence-specific DNA binding transcription factor activity		ISO	UniProtKB:Q02363	2290270	MGI:MGI:4834177	MGI	MGI:MGI:4834177
negative regulation of transcription from RNA polymerase II promoter		IGI	MGI:MGI:97276	2290270	MGI:MGI:1888583\|PMID:10835421	MGI	MGI:MGI:1888583 PMID:10835421
negative regulation of transcription from RNA polymerase II promoter		ISO	UniProtKB:P41137	2290270	MGI:MGI:4417868	RGD	MGI:MGI:4417868
negative regulation of transcription from RNA polymerase II promoter		IDA		2290270	MGI:MGI:3829299\|PMID:19109490	MGI	MGI:MGI:3829299 PMID:19109490
negative regulation of transcription from RNA polymerase II promoter		IGI	MGI:MGI:99698\|MGI:MGI:1096381	2290270	MGI:MGI:62826\|PMID:8233567	MGI	MGI:MGI:62826 PMID:8233567
negative regulation of transcription, DNA-dependent		IMP		2290270	MGI:MGI:4821067\|PMID:17681138	UniProtKB	MGI:MGI:4821067 PMID:17681138
negative regulation of transcription, DNA-dependent		ISO	UniProtKB:Q02363	2290270	MGI:MGI:4834177	MGI	MGI:MGI:4834177
negative regulation of transcription, DNA-dependent		IDA		2290270	MGI:MGI:5294534\|PMID:19362560	UniProtKB	MGI:MGI:5294534 PMID:19362560
neuron fate commitment		IMP		2290270	MGI:MGI:4821067\|PMID:17681138	UniProtKB	MGI:MGI:4821067 PMID:17681138
olfactory bulb development		IMP	MGI:MGI:3830733	2290270	MGI:MGI:3829299\|PMID:19109490	MGI	MGI:MGI:3829299 PMID:19109490
oligodendrocyte development		IMP	MGI:MGI:2384134	2290270	MGI:MGI:3621671\|PMID:11301021	MGI	MGI:MGI:3621671 PMID:11301021
Peyer's patch development		IGI	MGI:MGI:98510	2290270	MGI:MGI:3759740\|PMID:17452521	MGI	MGI:MGI:3759740 PMID:17452521
positive regulation of astrocyte differentiation		IMP	MGI:MGI:3830733	2290270	MGI:MGI:3829299\|PMID:19109490	MGI	MGI:MGI:3829299 PMID:19109490
positive regulation of blood pressure		IMP		2290270	MGI:MGI:4412240\|PMID:18474814	UniProtKB	MGI:MGI:4412240 PMID:18474814
positive regulation of cell cycle		ISO	UniProtKB:P41137	2290270	MGI:MGI:4417868	RGD	MGI:MGI:4417868
positive regulation of cell cycle arrest		IMP		2290270	MGI:MGI:4412240\|PMID:18474814	UniProtKB	MGI:MGI:4412240 PMID:18474814
positive regulation of cell proliferation		ISO	UniProtKB:P41137	2290270	MGI:MGI:4417868	RGD	MGI:MGI:4417868
positive regulation of erythrocyte differentiation		IMP	MGI:MGI:2384134	2290270	MGI:MGI:3805135\|PMID:18523151	MGI	MGI:MGI:3805135 PMID:18523151
positive regulation of fat cell differentiation		IMP	MGI:MGI:3806370	2290270	MGI:MGI:3804739\|PMID:18562627	MGI	MGI:MGI:3804739 PMID:18562627
positive regulation of gene expression		IMP		2290270	MGI:MGI:4412240\|PMID:18474814	UniProtKB	MGI:MGI:4412240 PMID:18474814
positive regulation of gene expression		IMP		2290270	MGI:MGI:4821067\|PMID:17681138	UniProtKB	MGI:MGI:4821067 PMID:17681138
positive regulation of macrophage differentiation		IGI	MGI:MGI:1857242\|MGI:MGI:2384134	2290270	MGI:MGI:3525032\|PMID:15616565	MGI	MGI:MGI:3525032 PMID:15616565
positive regulation of smooth muscle cell proliferation		IMP		2290270	MGI:MGI:4412240\|PMID:18474814	UniProtKB	MGI:MGI:4412240 PMID:18474814
positive regulation of transcription, DNA-dependent		IMP		2290270	MGI:MGI:4821067\|PMID:17681138	UniProtKB	MGI:MGI:4821067 PMID:17681138
regulation of G1/S transition of mitotic cell cycle		ISO	UniProtKB:Q02363	2290270	MGI:MGI:4834177	MGI	MGI:MGI:4834177
regulation of lipid metabolic process		IMP	MGI:MGI:3838359	2290270	MGI:MGI:4420353\|PMID:19740747	MGI	MGI:MGI:4420353 PMID:19740747

Cellular Component

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
chromatin		ISO	UniProtKB:P41137	2290270	MGI:MGI:4417868	RGD	MGI:MGI:4417868
cytoplasm		IDA		2290270	MGI:MGI:2670230\|PMID:12878164	MGI	MGI:MGI:2670230 PMID:12878164
cytoplasm		ISO	UniProtKB:Q02363	2290270	MGI:MGI:4834177	MGI	MGI:MGI:4834177
cytoplasm		ISO	UniProtKB:P41137	2290270	MGI:MGI:2154458	MGI	MGI:MGI:2154458
cytoplasm		IDA		2290270	MGI:MGI:1100167\|PMID:9418957	MGI	MGI:MGI:1100167 PMID:9418957
cytosol		ISO	UniProtKB:P41137	2290270	MGI:MGI:4417868	RGD	MGI:MGI:4417868
cytosol		ISO	UniProtKB:Q02363	2290270	MGI:MGI:4834177	MGI	MGI:MGI:4834177
nucleus		IDA		2290270	MGI:MGI:2670230\|PMID:12878164	MGI	MGI:MGI:2670230 PMID:12878164
nucleus		ISO	UniProtKB:Q02363	2290270	MGI:MGI:4834177	MGI	MGI:MGI:4834177
nucleus		ISO	UniProtKB:P41137	2290270	MGI:MGI:4417868	RGD	MGI:MGI:4417868
nucleus		ISO	UniProtKB:P41137	2290270	MGI:MGI:2154458	MGI	MGI:MGI:2154458
nucleus		IDA		2290270	MGI:MGI:1100167\|PMID:9418957	MGI	MGI:MGI:1100167 PMID:9418957
nucleus		IDA		2290270	MGI:MGI:3525032\|PMID:15616565	MGI	MGI:MGI:3525032 PMID:15616565
protein complex		IDA		2290270	MGI:MGI:4821067\|PMID:17681138	UniProtKB	MGI:MGI:4821067 PMID:17681138

Molecular Function

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
ion channel binding		ISO	UniProtKB:Q02363	2290270	MGI:MGI:4834177	MGI	MGI:MGI:4834177
protein binding		IPI	UniProtKB:Q61286	2290270	MGI:MGI:66136\|PMID:1922066	MGI	MGI:MGI:66136 PMID:1922066
protein binding		IPI	UniProtKB:P35428	2290270	MGI:MGI:4821067\|PMID:17681138	UniProtKB	MGI:MGI:4821067 PMID:17681138
protein binding		IPI	UniProtKB:Q9EQW6\|UniProtKB:Q9JKN5	2290270	MGI:MGI:3706482\|PMID:15280210	IntAct	MGI:MGI:3706482 PMID:15280210
protein binding		IPI	UniProtKB:P62137	2290270	MGI:MGI:3709531\|PMID:17274640	IntAct	MGI:MGI:3709531 PMID:17274640
protein binding		IPI	UniProtKB:P17433	2290270	MGI:MGI:3805135\|PMID:18523151	MGI	MGI:MGI:3805135 PMID:18523151
protein dimerization activity		IEA	InterPro:IPR011598	2290270	MGI:MGI:2152098	UniProtKB	MGI:MGI:2152098

Molecular Pathway Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
hypoxia inducible factor pathway		ISO	RGD:732001	6484113		PID	PID:200202
transforming growth factor-beta superfamily mediated signaling pathway		IEA	RGD:1551192	6907045		KEGG	mmu:04350

External Database Links
KEGG Pathway	Hippo signaling pathway
	TGF-beta signaling pathway
	Transcriptional misregulation in cancer
Pathway Interaction Database	HIF-1-alpha transcription factor network (PID:200202)
	Regulation of nuclear beta catenin signaling and target gene transcription (PID:200176)
	Validated targets of C-MYC transcriptional activation (PID:200056)
	Validated targets of C-MYC transcriptional repression (PID:200200)

Disease Annotations

Vascular System Injuries (ISS)

Gene-Chemical Interaction Annotations

	(-)-epigallocatechin 3-gallate (ISO)
	1-chloro-2,4-dinitrobenzene (ISO)
	17alpha-ethynylestradiol (EXP,ISO)
	17beta-estradiol (EXP,ISO)
	17beta-hydroxy-5alpha-androstan-3-one (ISO)
	2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)
	2,4-dinitrotoluene (ISO)
	2-amino-2-deoxy-D-glucopyranose (EXP)
	2-butoxyethanol (EXP)
	2-methoxyethanol (ISO)
	2-methylcholine (ISO)
	3-aminobenzamide (ISO)
	3-methylcholanthrene (EXP)
	5-aza-2'-deoxycytidine (ISO)
	5-fluorouracil (EXP,ISO)
	acetylsalicylic acid (ISO)
	aldehydo-D-glucosamine (EXP)
	all-trans-retinoic acid (ISO)
	ammonium chloride (ISO)
	Aroclor 1254 (ISO)
	arsenic atom (ISO)
	benzene (ISO)
	benzo[a]pyrene (EXP)
	beta-D-glucosamine (EXP)
	bis(2-ethylhexyl) phthalate (EXP)
	bisphenol A (ISO)
	butyric acid (ISO)
	cadmium dichloride (ISO)
	calcitriol (ISO)
	chloroprene (EXP,ISO)
	choline (EXP)
	ciguatoxin CTX1B (EXP)
	cisplatin (ISO)

	clozapine (ISO)
	copper atom (EXP,ISO)
	copper(0) (EXP,ISO)
	copper(2+) sulfate (ISO)
	copper(II) chloride (ISO)
	curcumin (ISO)
	cyclosporin A (EXP,ISO)
	Delta(9)-tetrahydrocannabinol (ISO)
	dexamethasone (ISO)
	diarsenic trioxide (EXP,ISO)
	dibenz[a,h]anthracene (ISO)
	dibenzo[a,l]pyrene (ISO)
	dibutyl phthalate (EXP)
	dichlorine (ISO)
	dichromium trioxide (ISO)
	diethylstilbestrol (EXP)
	dioxygen (ISO)
	doxorubicin (ISO)
	elemental selenium (ISO)
	fenofibrate (EXP)
	folic acid (EXP)
	formaldehyde (ISO)
	haloperidol (ISO)
	harmine (EXP)
	hydrogen chloride (ISO)
	hydrogen peroxide (ISO)
	L-methionine (EXP)
	lead diacetate (ISO)
	linalool (ISO)
	manganese atom (ISO)
	manganese(0) (ISO)
	manganese(II) chloride (ISO)
	methylmercury(1+) (ISO)

	N-acetyl-L-cysteine (ISO)
	nickel sulfate (ISO)
	nitroglycerin (ISO)
	ozone (ISO)
	paracetamol (EXP,ISO)
	perfluorooctane-1-sulfonic acid (EXP)
	perfluorooctanoic acid (EXP)
	phenobarbital (EXP,ISO)
	pioglitazone (ISO)
	pirinixic acid (EXP)
	pregnenolone 16alpha-carbonitrile (ISO)
	progesterone (ISO)
	propiconazole (EXP)
	prostaglandin F2alpha (ISO)
	quercetin (ISO)
	ranitidine (ISO)
	rosiglitazone (ISO)
	selenium atom (ISO)
	sevoflurane (ISO)
	silicon dioxide (EXP)
	tamoxifen (EXP)
	tert-butyl hydroperoxide (EXP,ISO)
	thioacetamide (ISO)
	trichloroethene (ISO)
	troglitazone (ISO)
	uranium atom (ISO)
	valproic acid (EXP)
	valsartan (ISO)
	vincaleukoblastine (ISO)
	zinc atom (ISO)
	zinc(0) (ISO)

Gene Ontology Annotations

Biological Process

	adipose tissue development (IMP)
	bundle of His development (IMP)
	cell development (IGI)
	cell maturation (IMP)
	cellular response to lithium ion (IDA)
	cellular senescence (IMP)
	embryonic digestive tract morphogenesis (IDA)
	entrainment of circadian clock (IMP)
	enucleate erythrocyte differentiation (IGI)
	epithelial cell differentiation involved in mammary gland alveolus development (IMP)
	heart development (IGI)
	leukocyte differentiation (IMP)
	lymph node development (TAS)
	mammary gland alveolus development (IMP)
	mammary gland epithelial cell proliferation (IMP)
	metanephros development (IMP)
	multicellular organismal development (IEA)
	natural killer cell differentiation (IGI,IMP)
	negative regulation of B cell differentiation (IMP)
	negative regulation of DNA binding (IDA)
	negative regulation of gene expression (IMP,ISO)
	negative regulation of neural precursor cell proliferation (IMP)
	negative regulation of neuron differentiation (IMP)

	negative regulation of oligodendrocyte differentiation (IMP)
	negative regulation of osteoblast differentiation (IGI)
	negative regulation of sequence-specific DNA binding transcription factor activity (ISO)
	negative regulation of transcription from RNA polymerase II promoter (IDA,IGI,ISO)
	negative regulation of transcription, DNA-dependent (IDA,IMP,ISO)
	neuron fate commitment (IMP)
	olfactory bulb development (IMP)
	oligodendrocyte development (IMP)
	Peyer's patch development (IGI)
	positive regulation of astrocyte differentiation (IMP)
	positive regulation of blood pressure (IMP)
	positive regulation of cell cycle (ISO)
	positive regulation of cell cycle arrest (IMP)
	positive regulation of cell proliferation (ISO)
	positive regulation of erythrocyte differentiation (IMP)
	positive regulation of fat cell differentiation (IMP)
	positive regulation of gene expression (IMP)
	positive regulation of macrophage differentiation (IGI)
	positive regulation of smooth muscle cell proliferation (IMP)
	positive regulation of transcription, DNA-dependent (IMP)
	regulation of G1/S transition of mitotic cell cycle (ISO)
	regulation of lipid metabolic process (IMP)

Cellular Component

	chromatin (ISO)
	cytoplasm (IDA,ISO)

	cytosol (ISO)
	nucleus (IDA,ISO)

protein complex (IDA)

Molecular Function

	ion channel binding (ISO)
	protein binding (IPI)

protein dimerization activity (IEA)

Molecular Pathway Annotations

	hypoxia inducible factor pathway (ISO)
	transforming growth factor-beta superfamily mediated signaling pathway (IEA)

External Database Links
KEGG Pathway	Hippo signaling pathway
	TGF-beta signaling pathway
	Transcriptional misregulation in cancer
Pathway Interaction Database	HIF-1-alpha transcription factor network (PID:200202)
	Regulation of nuclear beta catenin signaling and target gene transcription (PID:200176)
	Validated targets of C-MYC transcriptional activation (PID:200056)
	Validated targets of C-MYC transcriptional repression (PID:200200)

References - curated

1.	Kawai J, etal., Nature 2001 Feb 8;409(6821):685-90.
2.	Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3.	Matsumura ME, etal., J Biol Chem 2002 Mar 1;277(9):7293-7.
4.	MGD data from the GO Consortium
5.	MGD IEA
6.	Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73.
7.	Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology
8.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9.	RGD automated import pipeline for gene-chemical interactions

References - uncurated

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	20237272
	20308569
	20359476
	20375148
	20412781
	20422711
	20450257
	20453161
	20463050
	20534673
	20600660
	20674548
	20861012
	20943929
	21056086
	21060110
	21060113
	21068310
	21110107
	21129374
	21145943
	21178013
	21194568
	21266775
	21267068
	21330551
	21350014
	21354309
	21357262
	21385574
	21504804
	21587207
	21597012
	21666055
	21677750
	21679705
	21731673
	21946417
	21947283
	21953618
	21985998
	22012595
	22041901
	22057289
	22234186
	22391036
	22412967
	22421219
	22425249
	22430492
	22522171
	22560297
	22585759
	22588720
	22615585
	22711520
	22745378
	22936665
	22972921
	22991445
	23033267
	23063333
	23063798
	23103132
	23159228
	23325888
	7619531
	7637581
	8139914
	8188294
	8197168
	8224536
	8233567
	8586447
	8922523
	8989524
	9418957
	9831657
	9883721

RGD Disease Portals

Id2 has been annotated in the following RGD Disease Portals.

Biological Process

Cancer Pathways

Biological Process

Cardiovascular Diseases

Cardiovascular Pathways

Diabetes Pathways

Biological Process

Immune and Inflammatory Pathways

Biological Process

Neurological Pathways

Biological Process

Obesity Pathways

Biological Process

Respiratory Pathways

Genomics

Comparative Map Data

Id2 (Mus musculus)

Map	Chr	Position	Strand	Source
Mouse Genome Assembly GRCm38	12	25,093,799 - 25,096,092	-	NCBI
Mouse cM Map	12	8.57		NCBI
Mouse Celera Assembly	12	26,550,909 - 26,553,204	-	NCBI
Mouse Genome Assembly Build 37	12	25,778,664 - 25,780,957	-	NCBI
Mouse Genome Assembly Build 36.1	12	25,778,664 - 25,780,933	-	NCBI
Mouse Cytogenetic Map	12	B		NCBI

ID2 (Homo sapiens)

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	2	8,794,575 - 8,797,045	+	NCBI
Human Genome Assembly HuRef	2	8,668,297 - 8,670,767	+	NCBI
Human Genome Assembly GRCh37	2	8,822,113 - 8,824,583	+	NCBI
Human Genome Assembly Build 36	2	8,739,564 - 8,742,034	+	NCBI
Human Cytogenetic Map	2	p25		NCBI
Human Genome Assembly	2	8,772,710 - 8,775,179		NCBI

Id2 (Rattus norvegicus)

Map	Chr	Position	Strand	Source
Rat Cytogenetic Map	6	q16		NCBI
RGSC Genome Assembly v5.0	6	53,084,391 - 53,086,222	-	NCBI
RGSC Genome Assembly v3.4	6	42,781,476 - 42,783,307	-	NCBI
Rat Celera Assembly	6	41,019,266 - 41,021,097	-	NCBI
Genome Assembly 3.1	6	42,784,059 - 42,786,427	-	NCBI
RH 3.4	6	240.21		RGD

Position Markers

AI255428

Map	Chr	Position	Source
Mouse Genome Assembly GRCm38	12	25,094,333 - 25,094,476	UniSTS
Mouse Genome Assembly GRCm38	X	100,585,536 - 100,585,677	UniSTS
Mouse Whitehead/MRC_RH	12	219.97	UniSTS
Mouse cM Map	12	7.0	UniSTS
Mouse Celera Assembly	X	87,511,570 - 87,511,711	UniSTS
Mouse Celera Assembly	12	26,551,442 - 26,551,587	UniSTS
Mouse Genome Assembly Build 37	X	97,780,875 - 97,781,016	UniSTS
Mouse Genome Assembly Build 37	12	25,779,198 - 25,779,341	UniSTS
Mouse Cytogenetic Map	12	B	UniSTS
Mouse Cytogenetic Map	X	C3	UniSTS

RH94852

Map	Chr	Position	Source
Mouse Genome Assembly GRCm38	12	25,094,371 - 25,094,488	UniSTS
Mouse Genome Assembly GRCm38	X	100,585,524 - 100,585,639	UniSTS
Mouse cM Map	12	7.0	UniSTS
Mouse Celera Assembly	X	87,511,558 - 87,511,673	UniSTS
Mouse Celera Assembly	12	26,551,480 - 26,551,599	UniSTS
Mouse Genome Assembly Build 37	12	25,779,236 - 25,779,353	UniSTS
Mouse Genome Assembly Build 37	X	97,780,863 - 97,780,978	UniSTS
Mouse Cytogenetic Map	12	B	UniSTS
Mouse Cytogenetic Map	X	C3	UniSTS

PMC133998P2

Map	Chr	Position	Source
Mouse Genome Assembly GRCm38	12	25,095,318 - 25,096,010	UniSTS
Mouse cM Map	12	7.0	UniSTS
Mouse Celera Assembly	12	26,552,428 - 26,553,121	UniSTS
Mouse Genome Assembly Build 37	12	25,780,183 - 25,780,875	UniSTS
Mouse Cytogenetic Map	12	B	UniSTS

PMC140618P1

Map	Chr	Position	Source
Mouse Genome Assembly GRCm38	12	25,094,300 - 25,094,590	UniSTS
Mouse cM Map	12	7.0	UniSTS
Mouse Celera Assembly	12	26,551,409 - 26,551,701	UniSTS
Mouse Genome Assembly Build 37	12	25,779,165 - 25,779,455	UniSTS
Mouse Cytogenetic Map	12	B	UniSTS

RH126462

Map	Chr	Position	Source
Mouse Genome Assembly GRCm38	12	25,094,317 - 25,094,525	UniSTS
Mouse Whitehead/MRC_RH	12	212.49	UniSTS
Mouse cM Map	12	7.0	UniSTS
Mouse Celera Assembly	12	26,551,426 - 26,551,636	UniSTS
Mouse Genome Assembly Build 37	12	25,779,182 - 25,779,390	UniSTS
Mouse Cytogenetic Map	12	B	UniSTS

Idb2

Map	Chr	Position	Strand	Source
Mouse cM Map	12	7.0		UniSTS
Mouse Cytogenetic Map	12	B		UniSTS

Id2

Map	Chr	Position	Source
Mouse Genome Assembly GRCm38	12	25,098,649 - 25,098,771	UniSTS
Mouse cM Map	12	7.0	UniSTS
Mouse Celera Assembly	12	26,555,785 - 26,555,907	UniSTS
Mouse Genome Assembly Build 37	12	25,783,514 - 25,783,636	UniSTS
Mouse Cytogenetic Map	12	B	UniSTS

PMC305683P2

Map	Chr	Position	Source
Mouse Genome Assembly GRCm38	12	25,095,318 - 25,096,010	UniSTS
Mouse cM Map	12	7.0	UniSTS
Mouse Celera Assembly	12	26,552,428 - 26,553,121	UniSTS
Mouse Genome Assembly Build 37	12	25,780,183 - 25,780,875	UniSTS
Mouse Cytogenetic Map	12	B	UniSTS

Idb2

Map	Chr	Position	Strand	Source
Mouse cM Map	12	7.0		UniSTS
Mouse Cytogenetic Map	12	B		UniSTS

Id2

Map	Chr	Position	Strand	Source
Mouse Cytogenetic Map	12	B		UniSTS

QTLs in Region (Mouse Genome Assembly Build 37)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4141112	Tglq2a_m	triglyceride QTL 2a (mouse)			Not determined		12	1	27877539	Mouse
4141436	Chldq7_m	cholesterol and HDL QTL 7 (mouse)			Not determined		12	1	27877539	Mouse
4141713	Pltq3_m	platelet quantitative locus 3 (mouse)			Not determined		12	1	27877539	Mouse
4142163	Ascla5_m	atherosclerotic lesion area 5 (mouse)			Not determined		12	1	31353819	Mouse
1301207	Circp1_m	circadian photosensitivity 1 (mouse)			Not determined		12	1	33387144	Mouse
4141660	Nbwa1_m	NZB and NZW autoimmunity 1 (mouse)			Not determined		12	296939	34297107	Mouse
1301574	Lmblgq5_m	limb length QTL 5 (mouse)			Not determined		12	553252	34553422	Mouse
1301163	Eae16_m	susceptibility to experimental allergic encephalomyelitis 16 (mouse)			Not determined		12	8358024	42358167	Mouse
1301446	Elsgp4_m	elevated serum gp70 4 (mouse)			Not determined		12	8358024	42358167	Mouse
1301037	Cd4ts5_m	CD4 T cell subset 5 (mouse)			Not determined		12	8987310	42987447	Mouse
1301723	Fcsa7_m	femoral cross-sectional area 7 (mouse)			Not determined		12	10125870	44125978	Mouse
1301141	Faq5_m	fluctuating asymmetry QTL 5 (mouse)			Not determined		12	10750456	44750601	Mouse
1558879	Avptaq2_m	Avp transcript abundance QTL 2 (mouse)			Not determined		12	13858603	47858749	Mouse
4142128	Fl1sa_m	fatty liver 1 in SMXA (mouse)			Not determined		12	15390581	49390727	Mouse
1301989	Hdlq18_m	HDL QTL 18 (mouse)			Not determined		12	18474805	52474947	Mouse
4142494	Pmncq1_m	polymorphonuclear cell concentration QTL 1 (mouse)			Not determined		12	18474805	52474947	Mouse
1301694	Rear2_m	rearing 2 (mouse)			Not determined		12	18725677	52725810	Mouse
1301428	Etoms_m	etomidate sensitivity (mouse)			Not determined		12	18725677	52725810	Mouse
1300870	Ath18_m	atherosclerosis 18 (mouse)			Not determined		12	18894639	52894740	Mouse
1558978	Cplaq10_m	circadian period of locomotor activity 10 (mouse)			Not determined		12	19628031	53628138	Mouse
4141645	Ntta2_m	neurotensin transcript abundance 2 (mouse)			Not determined		12	22503869	56503980	Mouse
1302172	Skts5_m	skin tumor susceptibility 5 (mouse)			Not determined		12	22825454	56825604	Mouse

Sequence

Nucleotide Sequences

Nucleotide RefSeqs	NM_010496	(Get FASTA)	Search GEO for Microarray Profiles
GenBank Nucleotide	AAHY01098419	(Get FASTA)	Search GEO for Microarray Profiles
	AC116680	(Get FASTA)	Search GEO for Microarray Profiles
	AF077860	(Get FASTA)	Search GEO for Microarray Profiles
	AF077861	(Get FASTA)	Search GEO for Microarray Profiles
	AK003222	(Get FASTA)	Search GEO for Microarray Profiles
	AK013239	(Get FASTA)	Search GEO for Microarray Profiles
	AK013378	(Get FASTA)	Search GEO for Microarray Profiles
	AK135547	(Get FASTA)	Search GEO for Microarray Profiles
	AK146346	(Get FASTA)	Search GEO for Microarray Profiles
	AK146606	(Get FASTA)	Search GEO for Microarray Profiles
	BC006921	(Get FASTA)	Search GEO for Microarray Profiles
	BC053699	(Get FASTA)	Search GEO for Microarray Profiles
	BQ044638	(Get FASTA)	Search GEO for Microarray Profiles
	CH466526	(Get FASTA)	Search GEO for Microarray Profiles
	CT010478	(Get FASTA)	Search GEO for Microarray Profiles
	M69293	(Get FASTA)	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

NM_010496

RefSeq Status:

VALIDATED

Type:

CODING

Protein Acc Id:

NP_034626

Position:

Map	Chr	Position	Strand	Source
Mouse Genome Assembly GRCm38	12	25,093,799 - 25,096,092	-	ENTREZGENE
Mouse cM Map	12		-	ENTREZGENE
Mouse Celera Assembly	12	26,550,909 - 26,553,204	-	RGD
Mouse Genome Assembly Build 37	12	25,778,664 - 25,780,957	-	RGD

Protein Sequences

Protein RefSeqs	NP_034626	(Get FASTA)
GenBank Protein	AAA79771	(Get FASTA)
	AAD05214	(Get FASTA)
	AAH06921	(Get FASTA)
	AAH53699	(Get FASTA)
	BAB22651	(Get FASTA)
	BAE22577	(Get FASTA)
	BAE27099	(Get FASTA)
	BAE27298	(Get FASTA)
	EDL36979	(Get FASTA)
	P41136	(Get FASTA)

Promoters

RGD ID:

6846978

Promoter ID:

MM_ACW:10248

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Kidney, Liver

Transcripts:

ID2.CSEP07-UNSPLICED

Position:

Map	Chr	Position	Strand	Source
Mouse Genome Assembly Build 36.1	12	25,779,546 - 25,780,257	-	MPROMDB

RGD ID:

6823067

Promoter ID:

MM_KWN:11369

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

NM_010496

Position:

Map	Chr	Position	Strand	Source
Mouse Genome Assembly Build 36.1	12	25,780,699 - 25,781,199	-	MPROMDB

RGD ID:

6886580

Promoter ID:

EPDNEW_M6741

Type:

preliminary

Name:

Id2_1

Description:

inhibitor of DNA binding 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Position:

Map	Chr	Position	Strand	Source
Mouse Genome Assembly Build 36.1	12	25,780,954 - 25,781,014		EPDNEW

RGD ID:

6849005

Promoter ID:

MM_XEF:1479

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung

Transcripts:

NM_001131810

Position:

Map	Chr	Position	Strand	Source
Mouse Genome Assembly Build 36.1	12	25,783,359 - 25,783,859	-	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSMUSG00000020644	ENTREZGENE
Ensembl Protein	ENSMUSP00000020974	ENTREZGENE
Ensembl Transcript	ENSMUST00000020974	ENTREZGENE
Entrez Gene	15902	ENTREZGENE
Gene3D-CATH	HLH_DNA_bd	UniProtKB/Swiss-Prot
Germonline	ENSMUSG00000020644
HomoloGene Group ID	1632	ENTREZGENE
InterPro	DNA-bd_prot-inh	UniProtKB/Swiss-Prot
	HLH_DNA-bd	UniProtKB/Swiss-Prot
IPI	IPI00111448	UniProtKB/Swiss-Prot
KEGG Report	mmu:15902	ENTREZGENE, UniProtKB/Swiss-Prot
MGD	MGI:96397	ENTREZGENE
PANTHER	PTHR11723	UniProtKB/Swiss-Prot
Pfam	HLH	UniProtKB/Swiss-Prot
PROSITE	HLH	UniProtKB/Swiss-Prot
SMART	HLH	UniProtKB/Swiss-Prot
Superfamily-SCOP	HLH_basic	UniProtKB/Swiss-Prot
UniGene	Mm.34871	ENTREZGENE
UniProt	ID2_MOUSE	UniProtKB/Swiss-Prot
	Q545T4_MOUSE	UniProtKB/TrEMBL

More on Id2
	Entrez Gene
	Ensembl Gene
	Genome Browser
	MGI Report
	NCBI Map Viewer
	Vista
	Vista + UCSC

RGD Object Information
RGD ID:	1551192
Created:	2005-09-30
Species:	Mus musculus
Last Modified:	2013-04-16
Status:	ACTIVE