Pros1 (protein S (alpha)) - Rat Genome Database

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Gene: Pros1 (protein S (alpha)) Mus musculus
Analyze
Symbol: Pros1
Name: protein S (alpha)
RGD ID: 1550610
MGI Page MGI
Description: Predicted to enable calcium ion binding activity. Predicted to be involved in negative regulation of coagulation and positive regulation of phagocytosis. Predicted to act upstream of or within blood coagulation and fibrinolysis. Located in extracellular space. Is expressed in several structures, including brain; frenulum; liver; and tooth. Human ortholog(s) of this gene implicated in autosomal dominant thrombophilia due to protein S deficiency; autosomal recessive thrombophilia due to protein S deficiency; cerebral infarction; and protein S deficiency. Orthologous to human PROS1 (protein S).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AW214361; vitamin K-dependent protein S
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391662,674,670 - 62,749,709 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1662,674,670 - 62,749,709 (+)EnsemblGRCm39 Ensembl
GRCm381662,854,307 - 62,929,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1662,854,307 - 62,929,346 (+)EnsemblGRCm38mm10GRCm38
MGSCv371662,854,160 - 62,929,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361662,796,624 - 62,871,347 (+)NCBIMGSCv36mm8
Celera1663,162,946 - 63,237,718 (+)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1636.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-methoxyethanol  (ISO)
3-chloropropane-1,2-diol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
aristolochic acid A  (ISO)
Benoxacor  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt atom  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
desogestrel  (ISO)
dextran sulfate  (EXP)
dibenz[a,h]anthracene  (EXP)
diclofenac  (EXP)
dicrotophos  (ISO)
dienogest  (ISO)
diuron  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
fenoldopam  (ISO)
fenthion  (EXP)
fipronil  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
genistein  (ISO)
gentamycin  (ISO)
gestodene  (ISO)
glafenine  (ISO)
isotretinoin  (ISO)
L-ascorbic acid  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
norgestimate  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
Soman  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vitamin K  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. PROS1 genotype phenotype relationships in a large cohort of adults with suspicion of inherited quantitative protein S deficiency. Alhenc-Gelas M, etal., Thromb Haemost. 2016 Feb 29;115(3):570-9. doi: 10.1160/TH15-05-0391. Epub 2015 Oct 15.
2. Characterization and structural impact of five novel PROS1 mutations in eleven protein S-deficient families. Andersen BD, etal., Thromb Haemost. 2001 Dec;86(6):1392-9.
3. A novel mutation in intron K of the PROS1 gene causes aberrant RNA splicing and is a common cause of protein S deficiency in a UK thrombophilia cohort. Beauchamp NJ, etal., Thromb Haemost. 1998 Jun;79(6):1086-91.
4. Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway. Bouwens EA, etal., J Thromb Haemost. 2013 Jun;11 Suppl 1:242-53. doi: 10.1111/jth.12247.
5. Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. Burstyn-Cohen T, etal., J Clin Invest. 2009 Oct;119(10):2942-53. doi: 10.1172/JCI39325.
6. The Ser 460 to Pro substitution of the protein S alpha (PROS1) gene is a frequent mutation associated with free protein S (type IIa) deficiency. Duchemin J, etal., Blood. 1995 Nov 1;86(9):3436-43.
7. Genotype and laboratory and clinical phenotypes of protein s deficiency. Duebgen S, etal., Am J Clin Pathol. 2012 Feb;137(2):178-84. doi: 10.1309/AJCP40UXNBTXGKUX.
8. The protein C pathway. Esmon CT, Chest. 2003 Sep;124(3 Suppl):26S-32S.
9. Differential regulation of protein S expression in hepatocytes and sinusoidal endothelial cells in rats with cirrhosis. Fujii K, etal., J Thromb Haemost. 2006 Dec;4(12):2607-15. Epub 2006 Sep 22.
10. Combined occurrence of a heterozygous missense mutation in the protein C gene and allelic exclusion of one protein S allele leading to severe venous thrombosis. Knoll B, etal., Thromb Res. 2001 Jul 1;103(1):3-8.
11. Genetic predisposition of white matter infarction with protein S deficiency and R355C mutation. Leung TW, etal., Neurology. 2010 Dec 14;75(24):2185-9. doi: 10.1212/WNL.0b013e3182020379.
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Early embryonic expression of murine coagulation system components. Ong K, etal., Thromb Haemost 2000 Dec;84(6):1023-30.
16. Gross deletions/duplications in PROS1 are relatively common in point mutation-negative hereditary protein S deficiency. Pintao MC, etal., Hum Genet. 2009 Sep;126(3):449-56. doi: 10.1007/s00439-009-0687-9. Epub 2009 May 23.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex. Rezende SM, etal., Blood. 2004 Feb 15;103(4):1192-201. Epub 2003 Aug 7.
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Clarification of the risk for venous thrombosis associated with hereditary protein S deficiency by investigation of a large kindred with a characterized gene defect. Simmonds RE, etal., Ann Intern Med. 1998 Jan 1;128(1):8-14.
23. Identification of a novel PROS1 c.1113T-->GG frameshift mutation in a family with mixed type I/type III protein S deficiency. ten Kate MK, etal., Haematologica. 2006 Aug;91(8):1151-2.
24. Protein S Protects against Podocyte Injury in Diabetic Nephropathy. Zhong F, etal., J Am Soc Nephrol. 2018 Mar 6. pii: ASN.2017030234. doi: 10.1681/ASN.2017030234.
Additional References at PubMed
PMID:8029814   PMID:8148380   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11130978   PMID:11217851   PMID:12477932   PMID:12520002   PMID:12904583  
PMID:15782199   PMID:16141072   PMID:16141073   PMID:16910173   PMID:19036061   PMID:19567881   PMID:19815836   PMID:20348395   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22043818  
PMID:23259948   PMID:23850380   PMID:24006456   PMID:24952961   PMID:25265470   PMID:25308179   PMID:26251307   PMID:27034374   PMID:27049947   PMID:27207541   PMID:27753164   PMID:28512399  
PMID:28686706   PMID:29317453   PMID:29419409   PMID:29545796   PMID:29706963   PMID:29708510   PMID:29721990   PMID:29871951   PMID:30735494   PMID:32276277   PMID:33848267   PMID:36951067  
PMID:36989576   PMID:37277061  


Genomics

Comparative Map Data
Pros1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391662,674,670 - 62,749,709 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1662,674,670 - 62,749,709 (+)EnsemblGRCm39 Ensembl
GRCm381662,854,307 - 62,929,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1662,854,307 - 62,929,346 (+)EnsemblGRCm38mm10GRCm38
MGSCv371662,854,160 - 62,929,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361662,796,624 - 62,871,347 (+)NCBIMGSCv36mm8
Celera1663,162,946 - 63,237,718 (+)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1636.43NCBI
PROS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38393,873,051 - 93,973,896 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl393,873,051 - 93,980,003 (-)EnsemblGRCh38hg38GRCh38
GRCh37393,591,895 - 93,692,740 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36395,074,647 - 95,175,395 (-)NCBINCBI36Build 36hg18NCBI36
Build 34395,074,646 - 95,175,395NCBI
Celera391,974,425 - 92,076,408 (-)NCBICelera
Cytogenetic Map3q11.1NCBI
HuRef390,954,621 - 91,055,633 (-)NCBIHuRef
CHM1_1393,558,922 - 93,656,016 (-)NCBICHM1_1
T2T-CHM13v2.0396,571,223 - 96,678,047 (-)NCBIT2T-CHM13v2.0
Pros1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81113,676,310 - 13,757,858 (+)NCBIGRCr8
mRatBN7.211230,597 - 311,288 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl11230,696 - 311,286 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx118,826,855 - 8,907,393 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0111,620,112 - 1,700,666 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.011724,894 - 805,450 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.071,206,648 - 1,288,140 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl71,206,648 - 1,288,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.071,199,864 - 1,279,998 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera13237,157 - 317,730 (+)NCBICelera
Cytogenetic Map11p12NCBI
Pros1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554073,535,388 - 3,565,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554073,514,900 - 3,566,165 (+)NCBIChiLan1.0ChiLan1.0
PROS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2291,781,226 - 91,886,734 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1391,785,656 - 91,890,489 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0390,934,641 - 91,039,059 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1397,615,734 - 97,719,057 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl397,615,734 - 97,718,756 (-)Ensemblpanpan1.1panPan2
PROS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1331,628,074 - 1,691,441 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl331,628,105 - 1,692,058 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,807,559 - 1,871,177 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0331,727,844 - 1,791,314 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl331,727,846 - 1,791,431 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1331,637,294 - 1,700,492 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0331,671,507 - 1,735,141 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0331,896,104 - 1,960,217 (-)NCBIUU_Cfam_GSD_1.0
Pros1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602155,405,321 - 155,496,524 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493666619,387 - 110,014 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493666618,303 - 110,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13165,911,366 - 165,999,811 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113165,915,298 - 165,999,118 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PROS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12286,728,089 - 86,840,413 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2286,728,339 - 86,840,356 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604179,820,400 - 79,954,563 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pros1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247896,621,803 - 6,704,033 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pros1
2377 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:431
Count of miRNA genes:345
Interacting mature miRNAs:376
Transcripts:ENSMUST00000023629, ENSMUST00000127502, ENSMUST00000155940
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162879281362792952Mouse
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162879281362792952Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163231279566312933Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3252290965466552Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
26884416Bzwq5_mbi-zygomatic width QTL 5, 5 week (mouse)163732036284696888Mouse
4142112Skts-fp3_mskin tumor susceptibility in FVB and PWK 3 (mouse)Not determined164005388172924385Mouse
11522747Eae41_mexperimental allergic encephalomyelitis susceptibility 41 (mouse)164039913478015472Mouse
1301138Pcd4ts3_mp-glycoprotein positive CD4 T cell subset 3 (mouse)Not determined164059392374594076Mouse
1357778Diobq_mdiet-induced obesity QTL (mouse)Not determined164219781782331174Mouse
4141212Imraq3_mimmune response to AAV2 QTL 3 (mouse)Not determined164438335078383506Mouse
1301719Remslp3_mrapid eye movement sleep 3 (mouse)Not determined164438335078383506Mouse
1558836Dice1b_mdetermination of interleukin 4 commitment 1b (mouse)Not determined164551100072274485Mouse
14928310Manh80_mmandible shape 80 (mouse)164821984182219841Mouse
1301394Eae11_msusceptibility to experimental allergic encephalomyelitis 11 (mouse)Not determined165356189187562035Mouse
1301364Lith14_mlithogenic gene 14 (mouse)Not determined165566184689661961Mouse
1301125Sluc27_msusceptibility to lung cancer 27 (mouse)Not determined166160864495608764Mouse

Markers in Region
AW214361  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381662,928,953 - 62,929,047UniSTSGRCm38
GRCm381118,452,038 - 18,452,131UniSTSGRCm38
MGSCv371662,928,779 - 62,928,873UniSTSGRCm37
MGSCv371118,352,041 - 18,352,134UniSTSGRCm37
Celera1663,237,331 - 63,237,425UniSTS
Cytogenetic Map16C1.3UniSTS
Whitehead/MRC_RH16721.72UniSTS
L27439  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381662,928,347 - 62,928,539UniSTSGRCm38
MGSCv371662,928,173 - 62,928,365UniSTSGRCm37
Celera1663,236,725 - 63,236,917UniSTS
Cytogenetic Map16C1.3UniSTS
Whitehead/MRC_RH16720.81UniSTS
Whitehead_YAC16 UniSTS
Pros1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16C1.3UniSTS
cM Map16 UniSTS
L27439  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381662,928,791 - 62,928,932UniSTSGRCm38
MGSCv371662,928,617 - 62,928,758UniSTSGRCm37
Celera1663,237,169 - 63,237,310UniSTS
Cytogenetic Map16C1.3UniSTS
Whitehead/MRC_RH16720.81UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000023629   ⟹   ENSMUSP00000023629
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1662,674,670 - 62,749,709 (+)Ensembl
GRCm38.p6 Ensembl1662,854,307 - 62,929,346 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127502
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1662,741,830 - 62,748,753 (+)Ensembl
GRCm38.p6 Ensembl1662,921,467 - 62,928,390 (+)Ensembl
RefSeq Acc Id: ENSMUST00000155940
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1662,718,512 - 62,720,737 (+)Ensembl
GRCm38.p6 Ensembl1662,898,149 - 62,900,374 (+)Ensembl
RefSeq Acc Id: NM_011173   ⟹   NP_035303
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391662,674,670 - 62,749,707 (+)NCBI
GRCm381662,854,307 - 62,929,344 (+)NCBI
MGSCv371662,854,160 - 62,929,166 (+)RGD
Celera1663,162,946 - 63,237,718 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011245843   ⟹   XP_011244145
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391662,710,759 - 62,749,709 (+)NCBI
GRCm381662,890,334 - 62,929,346 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_035303   ⟸   NM_011173
- Peptide Label: preproprotein
- UniProtKB: P43483 (UniProtKB/Swiss-Prot),   Q08761 (UniProtKB/Swiss-Prot),   Q3TR66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011244145   ⟸   XM_011245843
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000023629   ⟸   ENSMUST00000023629
Protein Domains
EGF-like   Gla   Laminin G   Laminin G-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08761-F1-model_v2 AlphaFold Q08761 1-675 view protein structure

Promoters
RGD ID:6827383
Promoter ID:MM_KWN:21368
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000067401
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361662,853,859 - 62,854,359 (+)MPROMDB
RGD ID:13674212
Promoter ID:EPDNEW_M21255
Type:initiation region
Name:Pros1_1
Description:Mus musculus protein S , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381662,854,326 - 62,854,386EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1095733 AgrOrtholog
Ensembl Genes ENSMUSG00000022912 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023629 ENTREZGENE
  ENSMUST00000023629.9 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.740.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Coagulation_fac-like_Gla_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19128 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1095733 ENTREZGENE
NCBI Gene 19128 ENTREZGENE
PANTHER LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24040:SF0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gla UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/TrEMBL
PharmGKB PROS1 RGD
PhenoGen Pros1 PhenoGen
PRINTS GLABLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P43483 ENTREZGENE
  PROS_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TR66 ENTREZGENE, UniProtKB/TrEMBL
  Q3V0M0_MOUSE UniProtKB/TrEMBL
UniProt Secondary P43483 UniProtKB/Swiss-Prot