Fgl2 (fibrinogen-like protein 2) - Rat Genome Database

Name: Fgl2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Fgl2 (fibrinogen-like protein 2) Mus musculus

Analyze

Symbol:

Fgl2

Name:

fibrinogen-like protein 2

RGD ID:

732675

MGI Page

MGI

Description:

Acts upstream of or within several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; negative regulation of antigen processing and presentation; and negative regulation of memory T cell differentiation. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including endometrium epithelium; extraembryonic component; nervous system; placenta; and skeleton. Used to study autoimmune glomerulonephritis. Orthologous to human FGL2 (fibrinogen like 2).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

AI385601; associated with MHV-3 induced prothrombinase activity; cytotoxic T-lymphocyte-specific protein; fibroleukin; musfiblp; prothrombinase

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FGL2 (fibrinogen like 2)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Fgl2 (fibrinogen-like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fgl2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FGL2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FGL2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fgl2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FGL2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FGL2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fgl2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Fgl2 (fibrinogen-like 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	FGL2 (fibrinogen like 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fgl2a (fibrinogen-like 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Danio rerio (zebrafish):	fgl2b (fibrinogen-like 2b)	Alliance	DIOPT (OrthoFinder\|PANTHER\|ZFIN)
Caenorhabditis elegans (roundworm):	T15B7.1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6788	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Xenopus tropicalis (tropical clawed frog):	fgl2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	21,577,671 - 21,583,384 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	21,577,640 - 21,583,372 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	21,372,673 - 21,378,386 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	21,372,642 - 21,378,374 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	20,878,491 - 20,884,204 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	20,884,527 - 20,890,197 (+)	NCBI		MGSCv36	mm8
Celera	5	18,336,281 - 18,342,004 (+)	NCBI		Celera
Cytogenetic Map	5	A3	NCBI
cM Map	5	9.83	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic contact dermatitis (ISO)

autoimmune glomerulonephritis (IAGP)

Chromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MB (ISO)

COVID-19 (ISO)

Experimental Autoimmune Myocarditis (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (EXP)

1,2,4-trimethylbenzene (ISO)

1,2-dimethylhydrazine (EXP)

1-chloro-2,4-dinitrobenzene (ISO)

1-naphthyl isothiocyanate (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (ISO)

2-hydroxypropanoic acid (ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

acetohydrazide (EXP)

acrolein (EXP)

acrylamide (EXP)

aldehydo-D-glucose (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (ISO)

amphetamine (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

asbestos (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzoates (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

C60 fullerene (ISO)

cadmium dichloride (ISO)

cadmium sulfate (EXP)

cantharidin (EXP)

carbon nanotube (EXP)

cefaloridine (ISO)

CGP 52608 (ISO)

chromium(6+) (EXP)

Cuprizon (ISO)

cycloheximide (ISO)

cyclosporin A (ISO)

D-glucose (EXP)

DDT (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (EXP)

dibutyl phthalate (ISO)

dimethylarsinic acid (ISO)

dioxygen (EXP,ISO)

diquat (EXP)

diuron (ISO)

doxorubicin (ISO)

fenvalerate (ISO)

flavonoids (ISO)

folic acid (EXP)

fucoxanthin (EXP)

glucose (EXP)

irinotecan (ISO)

lipopolysaccharide (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (ISO)

N-Nitrosopyrrolidine (ISO)

naphthalenes (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

O-methyleugenol (ISO)

oxaliplatin (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (EXP,ISO)

phenobarbital (EXP)

pirinixic acid (EXP)

potassium bromate (EXP)

progesterone (EXP,ISO)

quercetin (ISO)

rac-lactic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

S-adenosyl-L-methioninate (EXP)

S-adenosyl-L-methionine (EXP)

sodium arsenate (EXP)

sodium arsenite (EXP)

sodium fluoride (EXP)

Soman (ISO)

sulforaphane (EXP)

tacrolimus hydrate (EXP,ISO)

tetrachloromethane (EXP)

thioacetamide (ISO)

titanium dioxide (EXP)

topotecan (ISO)

tributylstannane (ISO)

trichloroethene (ISO)

triphenyl phosphate (ISO)

triptonide (EXP)

undecane (ISO)

valproic acid (ISO)

vinclozolin (ISO)

zidovudine (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

killing of cells of another organism (IEA)

negative regulation of defense response to virus (IMP)

negative regulation of dendritic cell antigen processing and presentation (IMP)

negative regulation of macrophage antigen processing and presentation (IMP)

negative regulation of memory T cell differentiation (IMP)

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell (IMP)

Cellular Component

cell surface (ISO)

collagen-containing extracellular matrix (IBA)

extracellular region (IEA)

extracellular space (IBA)

Molecular Function

peptidase activator activity (ISO)

protein binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal B cell physiology (IAGP)

abnormal blood coagulation (IAGP)

abnormal dendritic cell physiology (IAGP)

abnormal glomerular mesangium morphology (IAGP)

abnormal Peyer's patch follicle morphology (IAGP)

abnormal regulatory T cell physiology (IAGP)

abnormal renal glomerulus morphology (IAGP)

abnormal T cell physiology (IAGP)

abnormal urine albumin level (IAGP)

decreased body size (IAGP)

decreased dendritic cell apoptosis (IAGP)

decreased kidney weight (IAGP)

decreased Peyer's patch number (IAGP)

decreased susceptibility to Coronaviridae infection (IAGP)

decreased susceptibility to Coronaviridae infection induced morbidity/mortality (IAGP)

embryonic lethality between somite formation and embryo turning, incomplete penetrance (IAGP)

enlarged spleen (IAGP)

glomerulonephritis (IAGP)

hematuria (IAGP)

hemorrhage (IAGP)

increased circulating creatinine level (IAGP)

increased dendritic cell number (IAGP)

increased IgA level (IAGP)

increased IgG level (IAGP)

increased IgM level (IAGP)

increased length of allograft survival (IAGP)

increased regulatory T cell number (IAGP)

increased T cell proliferation (IAGP)

kidney hemorrhage (IAGP)

renal glomerulus fibrosis (IAGP)

small kidney (IAGP)

weight loss (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.	Brady KP, etal., Genome Res 1997 Nov;7(11):1085-93.
2.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3.	MGDs mouse GO annotations	MGD data from the GO Consortium
4.	MGD IEA	MGD IEA
5.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Cloning and tissue expression of the tissue prothrombinase Fgl-2 in the Sprague-Dawley rat.	Rychlik DF, etal., J Soc Gynecol Investig 2003 Feb;10(2):67-73.
10.	Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23.	Sagane K, etal., Gene 1999 Aug 5;236(1):79-86.
11.	Fibrinogen-like protein-2 causes deterioration in cardiac function in experimental autoimmune myocarditis rats through regulation of programmed death-1 and inflammatory cytokines.	Zheng Z, etal., Immunology. 2018 Feb;153(2):246-252. doi: 10.1111/imm.12837. Epub 2017 Oct 16.

Additional References at PubMed

PMID:3550794	PMID:7606791	PMID:7609073	PMID:8530097	PMID:9271679	PMID:9302276	PMID:10187767	PMID:10349636	PMID:10384057	PMID:10614646	PMID:10704286	PMID:11042159
PMID:11076861	PMID:11170750	PMID:11994472	PMID:12477932	PMID:12682232	PMID:12752447	PMID:12840059	PMID:14742694	PMID:14976252	PMID:15100314	PMID:15489334	PMID:15905589
PMID:15998670	PMID:16141072	PMID:16141073	PMID:16437596	PMID:16602821	PMID:16709865	PMID:17037572	PMID:17550996	PMID:17997751	PMID:18097026	PMID:18798549	PMID:18991288
PMID:19085958	PMID:21469939	PMID:21756857	PMID:21873635	PMID:23127799	PMID:23375831	PMID:24146739	PMID:24303082	PMID:24604562	PMID:24745333	PMID:24952961	PMID:24990517
PMID:25200905	PMID:25955764	PMID:26718313	PMID:27717876	PMID:27760760	PMID:28487604	PMID:28494352	PMID:28713999	PMID:29054965	PMID:29341118	PMID:29441068	PMID:29756667
PMID:30619295	PMID:31202927	PMID:31743856	PMID:32133407	PMID:32795921	PMID:32863955	PMID:33075801	PMID:33168576	PMID:33676940	PMID:33998085	PMID:35125831	PMID:35767958
PMID:36085259	PMID:36300695	PMID:37051251	PMID:37734200	PMID:38056898	PMID:38191799

Genomics

Comparative Map Data

Fgl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	21,577,671 - 21,583,384 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	21,577,640 - 21,583,372 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	21,372,673 - 21,378,386 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	21,372,642 - 21,378,374 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	20,878,491 - 20,884,204 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	20,884,527 - 20,890,197 (+)	NCBI		MGSCv36	mm8
Celera	5	18,336,281 - 18,342,004 (+)	NCBI		Celera
Cytogenetic Map	5	A3	NCBI
cM Map	5	9.83	NCBI

FGL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	77,193,369 - 77,199,819 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	77,193,369 - 77,199,848 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	76,822,686 - 76,829,136 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	76,660,624 - 76,667,086 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	76,470,142 - 76,473,795	NCBI
Celera	7	71,523,351 - 71,529,814 (-)	NCBI		Celera
Cytogenetic Map	7	q11.23	NCBI
HuRef	7	71,425,321 - 71,431,783 (-)	NCBI		HuRef
CHM1_1	7	76,752,975 - 76,759,437 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	78,444,483 - 78,450,933 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	76,155,751 - 76,162,213 (-)	NCBI

Fgl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	14,602,762 - 14,608,405 (-)	NCBI		GRCr8
mRatBN7.2	4	13,710,566 - 13,716,207 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	13,710,575 - 13,716,207 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	18,837,881 - 18,843,545 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	14,647,254 - 14,652,909 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	13,023,530 - 13,029,194 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	10,323,598 - 10,329,241 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	10,323,607 - 10,329,241 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	10,315,666 - 10,321,309 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	9,176,333 - 9,181,976 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	9,178,562 - 9,181,975 (-)	NCBI
Celera	4	9,274,110 - 9,279,753 (-)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

Fgl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	7,899,309 - 7,902,722 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955410	7,899,263 - 7,903,499 (+)	NCBI	ChiLan1.0	ChiLan1.0

FGL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	95,044,215 - 95,109,732 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	143,308,854 - 143,374,372 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	69,114,082 - 69,120,575 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	82,926,035 - 82,932,550 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	82,926,266 - 82,932,550 (-)	Ensembl	panpan1.1		panPan2

FGL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	17,328,794 - 17,335,429 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	17,331,780 - 17,335,401 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	16,987,483 - 16,994,083 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	17,648,480 - 17,655,066 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	18	17,399,538 - 17,406,132 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	17,338,550 - 17,345,153 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	17,607,841 - 17,614,446 (-)	NCBI		UU_Cfam_GSD_1.0

Fgl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	59,496,212 - 59,501,673 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	20,619,931 - 20,652,981 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	20,619,955 - 20,625,416 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FGL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	102,868,802 - 102,875,576 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	102,869,044 - 102,875,564 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	113,105,965 - 113,115,736 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	9	q16-q17	NCBI

FGL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	71,735,486 - 71,741,951 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	71,735,253 - 71,742,954 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	32,255,115 - 32,263,210 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fgl2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624739	26,503,965 - 26,507,305 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624739	26,501,149 - 26,507,305 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fgl2
266 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	590
Count of miRNA genes:	402
Interacting mature miRNAs:	453
Transcripts:	ENSMUST00000035799
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301468	Eye1_m	eye weight 1 (mouse)			Not determined		5	1	21929650	Mouse
10412081	Bwq13_m	body weight QTL 13 (mouse)			Not determined		5	1	23606323	Mouse
12904958	Gmmq8_m	gastrocnemius muscle mass QTL 8 (mouse)					5	1	29421124	Mouse
10401122	Pgia41_m	proteoglycan induced arthritis 41 (mouse)			Not determined		5	823144	34823280	Mouse
15039371	Nmrs21_m	NAFLD-associated magnetic resonance shift 21 (mouse)					5	3504823	37504823	Mouse
1301806	Actd2_m	activity-distance traveled 2 (mouse)			Not determined		5	5384520	39384652	Mouse
4141207	Imrfq1_m	immune response to Factor IX QTL 1 (mouse)			Not determined		5	8124117	42124239	Mouse
7394748	Mom5_m	modifier of Min 5 (mouse)			Not determined		5	8847672	33475637	Mouse
1301693	Sle6_m	systemic lupus erythematosus susceptibility 6 (mouse)			Not determined		5	8890693	87841837	Mouse
1357478	Kdnw1_m	kidney weight 1 (mouse)			Not determined		5	8915949	40529869	Mouse
14696730	Kidlq1_m	kidney weight, left QTL 1 (mouse)					5	13563152	47563152	Mouse
1301685	Estq2_m	estradiol regulated response QTL 2 (mouse)			Not determined		5	15634084	49634190	Mouse
13432187	Actdse1_m	activity chamber total difference saline/ethanol 1 (mouse)					5	18199180	23099180	Mouse
1300719	Iba5_m	induction of brown adipocytes 5 (mouse)			Not determined		5	20686993	54687134	Mouse

Markers in Region

AI385601

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	21,377,000 - 21,377,086	UniSTS	GRCm38
MGSCv37	5	20,882,818 - 20,882,904	UniSTS	GRCm37
Celera	5	18,340,612 - 18,340,697	UniSTS
Cytogenetic Map	5	A3	UniSTS
cM Map	5	7.0	UniSTS
Whitehead/MRC_RH	5	230.97	UniSTS

M16238

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	21,376,612 - 21,376,772	UniSTS	GRCm38
MGSCv37	5	20,882,430 - 20,882,590	UniSTS	GRCm37
Celera	5	18,340,224 - 18,340,384	UniSTS
Cytogenetic Map	5	A3	UniSTS
cM Map	5	7.0	UniSTS
Whitehead/MRC_RH	5	232.0	UniSTS

Fgl2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	21,373,345 - 21,373,551	UniSTS	GRCm38
MGSCv37	5	20,879,163 - 20,879,369	UniSTS	GRCm37
Celera	5	18,336,953 - 18,337,159	UniSTS
Cytogenetic Map	5	A3	UniSTS
cM Map	5	7.0	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_008013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC157936	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF025818	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH001898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH005717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK009500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK036402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK036784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BB016276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC028893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB599038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466586	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	W13307	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000035799 ⟹ ENSMUSP00000046131

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	21,577,640 - 21,583,372 (+)	Ensembl
GRCm38.p6 Ensembl	5	21,372,642 - 21,378,374 (+)	Ensembl

RefSeq Acc Id:

NM_008013 ⟹ NP_032039

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	21,577,671 - 21,583,384 (+)	NCBI
GRCm38	5	21,372,673 - 21,378,386 (+)	ENTREZGENE
MGSCv37	5	20,878,491 - 20,884,204 (+)	RGD
Celera	5	18,336,281 - 18,342,004 (+)	RGD
cM Map	5		ENTREZGENE

Sequence:

show sequence

GGCTATTAAAGCGCCTGGTCAGGCTGGGCTGCCGCACTGCAAGGATGAGGCTTCCTGGTTGGTT
GTGGCTGAGTTCTGCCGTCCTCGCTGCCTGCCGAGCGGTGGAGGAGCACAACCTGACTGAGGGG
CTGGAGGATGCCAGCGCCCAGGCTGCCTGCCCCGCGAGGCTGGAGGGCAGCGGGAGGTGCGAGG
GGAGCCAGTGCCCCTTCCAGCTCACCCTGCCCACGCTGACCATCCAGCTCCCGCGGCAGCTTGG
CAGCATGGAGGAGGTGCTCAAAGAAGTGCGGACCCTCAAGGAAGCAGTGGACAGTCTGAAGAAA
TCCTGCCAGGACTGTAAGTTGCAGGCTGACGACCATCGAGATCCCGGCGGGAATGGAGGGAATG
GAGCAGAGACAGCCGAGGACAGTAGAGTCCAGGAACTGGAGAGTCAGGTGAACAAGCTGTCCTC
AGAGCTGAAGAATGCAAAGGACCAGATCCAGGGGCTGCAGGGGCGCCTGGAGACGCTCCATCTG
GTAAATATGAACAACATTGAGAACTACGTGGACAACAAAGTGGCAAATCTAACCGTTGTGGTCA
ACAGTTTGGATGGCAAGTGTTCCAAGTGTCCCAGCCAAGAACACATGCAGTCACAGCCGGTTCA
ACATCTAATATACAAAGATTGTTCCGACCACTACGTGCTAGGAAGGAGAAGCAGTGGGGCCTAC
AGAGTTACCCCTGATCACAGAAACAGCAGCTTTGAGGTCTACTGTGACATGGAGACCATGGGTG
GAGGCTGGACGGTGCTGCAGGCTCGCCTTGATGGCAGCACCAACTTCACCAGAGAGTGGAAAGA
CTACAAAGCCGGCTTTGGAAACCTTGAACGAGAATTTTGGTTGGGCAACGATAAAATTCATCTT
CTGACCAAGAGTAAGGAAATGATTTTGAGAATAGATCTTGAAGACTTTAATGGTCTCACACTTT
ATGCCTTGTATGATCAGTTTTATGTGGCTAATGAATTTCTCAAATACCGATTACACATCGGTAA
CTACAATGGCACGGCAGGGGATGCCTTGCGTTTCAGTCGACACTACAACCATGACCTGAGGTTT
TTCACAACCCCAGACAGAGACAACGATCGGTACCCCTCTGGGAACTGTGGGCTCTATTACAGCT
CAGGCTGGTGGTTTGATTCATGTCTCTCTGCCAACTTAAATGGCAAATATTACCACCAGAAATA
CAAAGGTGTCCGTAATGGGATTTTCTGGGGCACCTGGCCTGGTATAAACCAGGCACAGCCAGGT
GGCTACAAGTCCTCCTTCAAACAGGCCAAGATGATGATTAGGCCCAAGAATTTCAAGCCATAAA
TTGCTAGTGTTCATCTCTCTGGGCACTCACTATCTAAGAGGACGATGAATTCCTTCAGCCCTTT
ACCATATGTCTCAGTTTATATTCCTTTCCTATGGCTAAACATTTCCTTTAAAGCTTTACAGCTT
TTAGAATAAAGCTGAAAAGATCTAAAAAGACTCCTATGTTGCTGTTATATGAGGAATGCTTGAA
AGCACTGGAAATATTGACAATTATACATTATAATTGCAAAACCTTTCATTTTTATTAGTTGAAA
AGTTTCCTAATATTTTTATTATTTTTATAATAAAAACTAAATTATTCAGCAAGCTAGATTCTAT
ATACGCAAGTTTTATTTTCACTAGGGCTAAATATACACATTTGAGAATATACCAGTCCTTCCAG
GTACAACTGAAAGCCAAGAACTGTAGTATTATCTTTCGTCTAAGAAGAACTTAAAGCATTTTAG
TTCTCAAGAAGAAGGGCAGGGATGGGATTGGGGGCCAGGGACAATATGTATAGCTAAATGTATT
CATCTAATGCAAAATATGGCATTAAAATACCTAAAAATGTGGTAGCATAATATATGTCTCTTCC
CTCTCCAATTGAAAAATAATGTTACCCTGTAGACTTTGGTTTAGTGGTAATTCACTTACTGTTT
ATAGCCTGTTAGACCGCGATACAAAAGCTGCTTTATCCTCTCCCTCTGCTCTCTGTGCACAATG
GTTTGTGATGTAAGGTGCTAGACTACTGTAAGGTTTCCTTGGGGAAAGGCATGGTAAGGGAAAA
CACACTGGTTTATATTTTGAAAGCCAATCCTAATCCCAAAGCAATACTGTTGTCGAGGAGTCAA
CGTTCTAGGAAGCTGACTTTTCTAGAACAAATGTATTTATTAGGATGAATTTTGGAATTTTAGT
TTAAATATTATACATTTTAATCCTAAGCAGTCAATTGCTTATTTCATTCTTAGAAATTCAAAGA
ATATATACAATTTTAGCCAAATGTGAGTCCCTGGAATTCCTTACTTGTGGATGTCAAGGGTCAC
ATTAAAAGGCTCTGGGGGCAGTTTCACTCACTTTATTCTTGTGAAAAGGGGTCACTCAGAGAGA
AACAACCCAGCCGCACACTTAAACGTGCTCTTGGGTGGAATCTGAAGTGCCGCATGCAGTCAGT
CACGTGGAGTAACTGACTGTACAACATGCACTGTCTAAGCAATAACTTTGATCTTTAAGTTTTG
GTGTAGCTTCTAATATACTAACCAAGCTTTTGAAATATATGCACAAAGATTCCACCTTAGTTAT
TTTTAAAACATAACTAGGGAGGATATTTATTGTCTTGACTACTTAAACTTTCAAACATGTAGCC
ACTGTAAAAAAAAAAAAACTTTACAAAGAGCAAGATACTATTTTTGAAACATGCAACATGAAGT
TTTCAGGTGAATACAGTGACAACTAAGCTATTAATAATATAATTAAATTGCCAGCGTAAGCTAA
ATGCATGCTGAATTAAATGACCAAAATATAACGTAGATTTTAAAGCCTTTACCTACTTGGTAAA
ACAGTGAATGTAAGTGGCAGTAACCAATCTTATTTCTTTTTGCTTTTTAAAAAAGACTAAGAAG
ATTTTGATATTATACAATTCATGTGTTTCAAATCCTGTTTATTATATGTAGCCATATAAGTCTA
ATGACATTTCCATAATGAAAATTGATTTACCATAGCAAAAATACTATGTGTTCATCCTGAGTGT
GTCTTTCTCAGGGTAACAATGAATCCATGTAAATACTTTATCTTTGCACTTCCAATGGATCCAA
ATGTTGTTTTCTATTATAGTCTATGATATTCTTCTAATAATTCTTTAACACAGAAATTTATTTT
TGAATCATTTTCTGTCACTCATTTAAAAATATATTGTAGACTTTGATAATCTCTAATCTGTTTA
TTGAAATAGTCCTTAGCCTTAACAATTCACTGATATATGCTGATGTTCATTAATGTACACTATT
TGCCAATATGTATTTTTAGAGTCTTGGCTTCATTTGGGTGGCTAGCACTGATCTTAATGATCAC
TTTATTGCTGAACATCATTATTCTTTAAAAATGCCAAGTGGAACTAATTTCTTAGGAATCCAGT
TGATTTGCCTGTCACGAAACGAGAAAGCCATCTCTCTGAAAAGTAGTAACGCAGCAAATGTCCT
CAGTTCTCTGGTGGACAGAGCTCGTGTGCGAGGCTCAAGGAGCATTAGAATCCCAGGATGGGCT
GGACCTGGATTTTTCAGTAGCTGCCCCTCACTCTTCGATAAGTTTTCAAGATAGGTGGATATAT
GCAATTTCCATGAACTCTTGTTTAAGATTTATTTTCATTGATGTATAATTAAGGTTATGTTTAA
TGTTTCTTTAAAGCCTTGTAAAATAAAAGTTAATCTTTATATCTATCCTTCGATGTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_032039	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA37624	(Get FASTA)	NCBI Sequence Viewer
	AAB88814	(Get FASTA)	NCBI Sequence Viewer
	AAB88815	(Get FASTA)	NCBI Sequence Viewer
	AAB92553	(Get FASTA)	NCBI Sequence Viewer
	AAH28893	(Get FASTA)	NCBI Sequence Viewer
	BAC29413	(Get FASTA)	NCBI Sequence Viewer
	EDL03209	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000046131
	ENSMUSP00000046131.6
GenBank Protein	P12804	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_032039 ⟸ NM_008013
- Peptide Label:	precursor
- UniProtKB:	P12804 (UniProtKB/Swiss-Prot), Q544K3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRLPGWLWLSSAVLAACRAVEEHNLTEGLEDASAQAACPARLEGSGRCEGSQCPFQLTLPTLTI QLPRQLGSMEEVLKEVRTLKEAVDSLKKSCQDCKLQADDHRDPGGNGGNGAETAEDSRVQELES QVNKLSSELKNAKDQIQGLQGRLETLHLVNMNNIENYVDNKVANLTVVVNSLDGKCSKCPSQEH MQSQPVQHLIYKDCSDHYVLGRRSSGAYRVTPDHRNSSFEVYCDMETMGGGWTVLQARLDGSTN FTREWKDYKAGFGNLEREFWLGNDKIHLLTKSKEMILRIDLEDFNGLTLYALYDQFYVANEFLK YRLHIGNYNGTAGDALRFSRHYNHDLRFFTTPDRDNDRYPSGNCGLYYSSGWWFDSCLSANLNG KYYHQKYKGVRNGIFWGTWPGINQAQPGGYKSSFKQAKMMIRPKNFKP hide sequence

RefSeq Acc Id:

ENSMUSP00000046131 ⟸ ENSMUST00000035799

Protein Domains

Fibrinogen C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P12804-F1-model_v2	AlphaFold	P12804	1-432	view protein structure

Promoters

RGD ID:

6837517

Promoter ID:

MM_KWN:41488

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Lung, Spleen

Transcripts:

OTTMUST00000063122

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	5	20,878,361 - 20,878,861 (+)	MPROMDB

RGD ID:

6849179

Promoter ID:

MM_XEF:5320

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_2Hour, BoneMarrow_4Hour

Transcripts:

NM_001025539

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	5	20,880,916 - 20,881,502 (+)	MPROMDB

RGD ID:

6886062

Promoter ID:

EPDNEW_M6482

Type:

initiation region

Name:

Fgl2_1

Description:

Mus musculus fibrinogen-like protein 2 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	5	21,372,706 - 21,372,766	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:103266	AgrOrtholog
Ensembl Genes	ENSMUSG00000039899	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000035799	ENTREZGENE
	ENSMUST00000035799.6	UniProtKB/Swiss-Prot
Gene3D-CATH	3.90.215.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Fibrinogen-like_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Fibrinogen_a/b/g_C_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Fibrinogen_a/b/g_C_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Fibrinogen_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:14190	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:103266	ENTREZGENE
NCBI Gene	14190	ENTREZGENE
PANTHER	FIBRINOGEN/TENASCIN/ANGIOPOEITIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR19143:SF189	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Fibrinogen_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Fgl2	PhenoGen
PROSITE	FIBRINOGEN_C_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FIBRINOGEN_C_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
SMART	FBG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56496	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	FGL2_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
	Q544K3	ENTREZGENE, UniProtKB/TrEMBL
	Q71V31_MOUSE	UniProtKB/TrEMBL
	Q71V87_MOUSE	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Mammalian Phenotype

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Mammalian Phenotype