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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (R)-adrenaline | multiple interactions | EXP | | 6480464 | Propranolol inhibits the reaction [Epinephrine results in decreased expression of THY1] | CTD | PMID:7558147 | (R)-adrenaline | decreases expression | EXP | | 6480464 | Epinephrine results in decreased expression of THY1 | CTD | PMID:7558147 | (R)-noradrenaline | decreases expression | EXP | | 6480464 | Norepinephrine results in decreased expression of THY1 | CTD | PMID:7558147 | (R)-noradrenaline | multiple interactions | EXP | | 6480464 | Propranolol inhibits the reaction [Norepinephrine results in decreased expression of THY1] | CTD | PMID:7558147 | 1,4-dithiothreitol | multiple interactions | EXP | | 6480464 | Dithiothreitol inhibits the reaction [sodium arsenite promotes the reaction [THY1 protein binds to THY1 protein]] | CTD | PMID:11035063 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:3860 | 6480464 | Ethinyl Estradiol affects the expression of THY1 mRNA | CTD | PMID:16079270 | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:3860 | 6480464 | Ethinyl Estradiol results in decreased expression of THY1 mRNA | CTD | PMID:15576828 | 17beta-estradiol | affects expression | ISO | RGD:735861 | 6480464 | Estradiol affects the expression of THY1 mRNA | CTD | PMID:14699072 | 17beta-estradiol | multiple interactions | ISO | RGD:735861 | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of THY1 mRNA | CTD | PMID:17404688 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:735861 | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of THY1 mRNA] | CTD | PMID:11007951 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:735861 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of THY1 mRNA | CTD | PMID:11007951 | 2,4,6-trinitrobenzenesulfonic acid | increases expression | EXP | | 6480464 | Trinitrobenzenesulfonic Acid results in increased expression of THY1 mRNA | CTD | PMID:18200517 | 2,4,6-trinitrobenzenesulfonic acid | multiple interactions | EXP | | 6480464 | Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THY1 mRNA] | CTD | PMID:18200517 | 2-acetamidofluorene | increases expression | ISO | RGD:3860 | 6480464 | 2-Acetylaminofluorene results in increased expression of THY1 protein | CTD | PMID:17576600 | 2-butoxyethanol | decreases expression | EXP | | 6480464 | n-butoxyethanol results in decreased expression of THY1 mRNA | CTD | PMID:19812364 | all-trans-retinoic acid | decreases expression | ISO | RGD:735861 | 6480464 | Tretinoin results in decreased expression of THY1 mRNA | CTD | PMID:21934132 | ammonium chloride | affects expression | ISO | RGD:3860 | 6480464 | Ammonium Chloride affects the expression of THY1 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of THY1 mRNA | CTD | PMID:20713471 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of THY1 mRNA | CTD | PMID:21569818 | beta-cyclodextrin | multiple interactions | EXP | | 6480464 | betadex inhibits the reaction [sodium arsenite promotes the reaction [THY1 protein binds to THY1 protein]] | CTD | PMID:11035063 | curcumin | multiple interactions | EXP | | 6480464 | Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THY1 mRNA] | CTD | PMID:18200517 | cycloheximide | multiple interactions | ISO | RGD:735861 | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of THY1 mRNA] | CTD | PMID:11007951 | cyclophosphamide | decreases expression | EXP | | 6480464 | Cyclophosphamide results in decreased expression of THY1 mRNA | CTD | PMID:21041162 | cytarabine | decreases expression | ISO | RGD:735861 | 6480464 | Cytarabine results in decreased expression of THY1 mRNA | CTD | PMID:19194470 | dexamethasone | decreases expression | EXP | | 6480464 | Dexamethasone results in decreased expression of THY1 mRNA | CTD | PMID:21041162 | diazoxide | multiple interactions | EXP | | 6480464 | Propranolol inhibits the reaction [Isoproterenol results in decreased expression of THY1] | CTD | PMID:7558147 | diazoxide | decreases expression | EXP | | 6480464 | Isoproterenol results in decreased expression of THY1 | CTD | PMID:7558147 | dibutyl phthalate | increases expression | ISO | RGD:3860 | 6480464 | Dibutyl Phthalate results in increased expression of THY1 mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | ISO | RGD:735861 | 6480464 | Dibutyl Phthalate results in increased expression of THY1 protein | CTD | PMID:22552774 | diethylstilbestrol | decreases expression | EXP | | 6480464 | Diethylstilbestrol results in decreased expression of THY1 mRNA | CTD | PMID:21041162 | diuron | increases expression | ISO | RGD:3860 | 6480464 | Diuron results in increased expression of THY1 mRNA | CTD | PMID:21551480 | hydralazine | multiple interactions | ISO | RGD:735861 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of THY1 mRNA | CTD | PMID:17183730 | isoprenaline | decreases expression | EXP | | 6480464 | Isoproterenol results in decreased expression of THY1 | CTD | PMID:7558147 | isoprenaline | multiple interactions | EXP | | 6480464 | Propranolol inhibits the reaction [Isoproterenol results in decreased expression of THY1] | CTD | PMID:7558147 | ketamine | increases expression | ISO | RGD:3860 | 6480464 | Ketamine results in increased expression of THY1 mRNA | CTD | PMID:20080153 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:3860 | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of THY1 mRNA | CTD | PMID:18164116 | nitroglycerin | decreases expression | ISO | RGD:3860 | 6480464 | Nitroglycerin results in decreased expression of THY1 mRNA | CTD | PMID:12102619 | paclitaxel | increases expression | ISO | RGD:735861 | 6480464 | Paclitaxel results in increased expression of THY1 mRNA | CTD | PMID:19682730 | progesterone | multiple interactions | ISO | RGD:735861 | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of THY1 mRNA | CTD | PMID:17404688 | propranolol | multiple interactions | EXP | | 6480464 | Propranolol inhibits the reaction [Epinephrine results in decreased expression of THY1]; more ... | CTD | PMID:7558147 | raloxifene | affects expression | ISO | RGD:735861 | 6480464 | Raloxifene affects the expression of THY1 mRNA | CTD | PMID:14699072 | raloxifene | increases expression | ISO | RGD:3860 | 6480464 | Raloxifene results in increased expression of THY1 mRNA | CTD | PMID:15576828 | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of THY1 mRNA | CTD | PMID:17484886 | toluene | increases expression | EXP | | 6480464 | Toluene results in increased expression of THY1 mRNA | CTD | PMID:17870172 | valproic acid | multiple interactions | ISO | RGD:735861 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of THY1 mRNA | CTD | PMID:17183730 | zinc atom | increases expression | ISO | RGD:735861 | 6480464 | Zinc deficiency results in increased expression of THY1 mRNA | CTD | PMID:18356318 | zinc(0) | increases expression | ISO | RGD:735861 | 6480464 | Zinc deficiency results in increased expression of THY1 mRNA | CTD | PMID:18356318 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Leukocyte transendothelial migration |
| Pathway Interaction Database | amb2 Integrin signaling (PID:200127) |
| Beta2 integrin cell surface interactions (PID:200138) | |
| Beta3 integrin cell surface interactions (PID:200043) | |
| IL4-mediated signaling events (PID:200022) | |
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Leukocyte transendothelial migration |
| Pathway Interaction Database | amb2 Integrin signaling (PID:200127) |
| Beta2 integrin cell surface interactions (PID:200138) | |
| Beta3 integrin cell surface interactions (PID:200043) | |
| IL4-mediated signaling events (PID:200022) | |
Phenotype Annotations
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References - curated| 1. |
Dibas A, etal., Mol Vis. 2008 Sep 25;14:1770-83. |
| 2. |
MGD and Homologene mouse data transfer |
| 3. |
MGD data from the GO Consortium |
| 4. |
MGD IEA |
| 5. |
Moriuchi T, etal., Nature 1983 Jan 6;301(5895):80-2. |
| 6. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 7. |
RGD automated import pipeline |
| 8. |
RGD automated import pipeline for gene-chemical interactions |
References - uncurated| PubMed | 10102300 |
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RGD Disease Portals| Thy1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Thy1 (Mus musculus) |
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| THY1 (Homo sapiens) |
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| Thy1 (Rattus norvegicus) |
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Position Markers| PMC151011P1 |
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| PMC22863P1 |
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| Thy1 |
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| D8Wox34 |
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| Thy1 |
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| Thy1 |
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| Thy1 |
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| Thy1 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_009382 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01077606 | (Get FASTA) | Search GEO for Microarray Profiles |
| AC126459 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK003006 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK080366 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY445633 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC054436 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CD776450 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466522 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CX123560 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M10246 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M11160 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M12379 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M12380 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X02770 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X02771 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X02772 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X02773 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X03151 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X17683 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_009382 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_033408 | |||||||||||||||||||||||||
| Peptide Label: | preproprotein | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_033408 | (Get FASTA) |
| GenBank Protein | AAA40440 | (Get FASTA) |
| AAA40441 | (Get FASTA) | |
| AAA40443 | (Get FASTA) | |
| AAH54436 | (Get FASTA) | |
| AAO25750 | (Get FASTA) | |
| AAR17087 | (Get FASTA) | |
| CAA26548 | (Get FASTA) | |
| CAA26549 | (Get FASTA) | |
| CAA26550 | (Get FASTA) | |
| CAA26930 | (Get FASTA) | |
| EDL25558 | (Get FASTA) | |
| EDL25559 | (Get FASTA) | |
| P01831 | (Get FASTA) |
Promoters| RGD ID: | 6845242 | ||||||||||
| Promoter ID: | MM_KWN:57073 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day0, Brain, MEF_B4, MEF_B6 | ||||||||||
| Transcripts: | NM_009382 | ||||||||||
| Position: |
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| RGD ID: | 6850406 | ||||||||||
| Promoter ID: | EP11161 | ||||||||||
| Type: | single initiation site | ||||||||||
| Name: | MM_THY1 | ||||||||||
| Description: | Thy-1 (thymocyte) antigen/glycoprotein allotype 2,THY1 or THY-1 gene. | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Tissues & Cell Lines: | brain, thymocytes | ||||||||||
| Experiment Methods: | Nuclease protection; Primer extension | ||||||||||
| Position: |
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| RGD ID: | 6883128 | ||||||||||
| Promoter ID: | EPDNEW_M5015 | ||||||||||
| Type: | preliminary | ||||||||||
| Name: | Thy1_1 | ||||||||||
| Description: | thymus cell antigen 1, theta | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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| RGD ID: | 6845240 | ||||||||||
| Promoter ID: | MM_KWN:57074 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Brain, MEF_B6 | ||||||||||
| Transcripts: | ENSMUST00000034509 | ||||||||||
| Position: |
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| RGD ID: | 6848488 | ||||||||||
| Promoter ID: | MM_ACW:50290 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Brain | ||||||||||
| Transcripts: | THY1.DSEP07 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000032011 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000110489 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000114840 | ENTREZGENE |
| Entrez Gene | 21838 | ENTREZGENE |
| Gene3D-CATH | Ig-like_fold | UniProtKB/Swiss-Prot |
| Germonline | ENSMUSG00000032011 | |
| HomoloGene Group ID | 4580 | ENTREZGENE |
| InterPro | Ig-like | UniProtKB/Swiss-Prot |
| Ig-like_fold | UniProtKB/Swiss-Prot | |
| Ig_V-set_subgr | UniProtKB/Swiss-Prot | |
| Immunoglobulin | UniProtKB/Swiss-Prot | |
| IPI | IPI00109727 | UniProtKB/Swiss-Prot |
| KEGG Report | mmu:21838 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:98747 | ENTREZGENE |
| Pfam | PF00047 | UniProtKB/Swiss-Prot |
| PROSITE | IG_LIKE | UniProtKB/Swiss-Prot |
| SMART | IGv | UniProtKB/Swiss-Prot |
| UniGene | Mm.3951 | ENTREZGENE |
| UniProt | Q53YX2_MOUSE | UniProtKB/TrEMBL |
| THY1_MOUSE | UniProtKB/Swiss-Prot |
| More on Thy1 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 11418 |
| Created: | 2000-05-25 |
| Species: | Mus musculus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




