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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | decreases expression | ISO | RGD:732396 | 6480464 | Estradiol results in decreased expression of JUP mRNA | CTD | PMID:16474171 | 2,2',4,4',5,5'-hexachlorobiphenyl | increases degradation | ISO | RGD:620412 | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of JUP protein | CTD | PMID:19464575 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of JUP mRNA | CTD | PMID:17035482 PMID:17586704 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of JUP mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:732396 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of JUP mRNA | CTD | PMID:20106945 PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of JUP mRNA | CTD | PMID:17586704 PMID:17035482 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:620412 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of JUP mRNA | CTD | PMID:12478657 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:620412 | 6480464 | Tetrachlorodibenzodioxin affects the localization of and results in decreased expression of JUP protein | CTD | PMID:12478657 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:732396 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of JUP mRNA | CTD | PMID:20106945 | 2-methylcholine | affects expression | ISO | RGD:732396 | 6480464 | beta-methylcholine affects the expression of JUP mRNA | CTD | PMID:21179406 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of JUP mRNA | CTD | PMID:20188158 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:732396 | 6480464 | decitabine results in increased expression of JUP mRNA; more ... | CTD | PMID:16887905 PMID:18974268 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:732396 | 6480464 | decitabine results in increased expression of JUP mRNA; more ... | CTD | PMID:18974268 PMID:16887905 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:732396 | 6480464 | DNMT3B protein affects the reaction [decitabine results in increased expression of JUP protein]; more ... | CTD | PMID:16887905 | ammonium chloride | decreases expression | ISO | RGD:620412 | 6480464 | Ammonium Chloride results in decreased expression of JUP protein | CTD | PMID:16483693 | bisphenol A | decreases expression | ISO | RGD:732396 | 6480464 | bisphenol A results in decreased expression of JUP mRNA | CTD | PMID:16474171 | C60 fullerene | increases expression | ISO | RGD:620412 | 6480464 | fullerene C60 results in increased expression of JUP mRNA | CTD | PMID:19167457 | cadmium dichloride | increases expression | ISO | RGD:620412 | 6480464 | Cadmium Chloride results in increased expression of JUP mRNA | CTD | PMID:21297351 | chlordecone | multiple interactions | ISO | RGD:732396 | 6480464 | Chlordecone inhibits the reaction [CDH1 protein binds to JUP protein] | CTD | PMID:11695219 | clofibrate | decreases expression | EXP | | 6480464 | Clofibrate results in decreased expression of JUP mRNA | CTD | PMID:17585979 | cobalt dichloride | decreases expression | ISO | RGD:732396 | 6480464 | cobaltous chloride results in decreased expression of JUP mRNA | CTD | PMID:19320972 | cocaine | affects expression | ISO | RGD:620412 | 6480464 | Cocaine affects the expression of JUP mRNA | CTD | PMID:20187946 | coumestrol | multiple interactions | ISO | RGD:732396 | 6480464 | [Coumestrol co-treated with resveratrol] results in decreased expression of JUP mRNA | CTD | PMID:19167446 | coumestrol | decreases expression | ISO | RGD:732396 | 6480464 | Coumestrol results in decreased expression of JUP mRNA | CTD | PMID:19167446 | cyclosporin A | decreases expression | ISO | RGD:732396 | 6480464 | Cyclosporine results in decreased expression of JUP mRNA | CTD | PMID:20106945 | cyclosporin A | increases expression | ISO | RGD:732396 | 6480464 | Cyclosporine results in increased expression of JUP mRNA | CTD | PMID:21163907 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of JUP mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of JUP mRNA | CTD | PMID:17361019 PMID:21266533 | dibutyl phthalate | increases expression | ISO | RGD:620412 | 6480464 | Dibutyl Phthalate results in increased expression of JUP mRNA | CTD | PMID:21266533 | dichlorine | increases expression | ISO | RGD:620412 | 6480464 | Chlorine results in increased expression of JUP mRNA | CTD | PMID:18636392 | dichlorine | multiple interactions | ISO | RGD:620412 | 6480464 | [Ozone co-treated with Chlorine] results in decreased expression of JUP mRNA | CTD | PMID:18636392 | genistein | decreases expression | ISO | RGD:732396 | 6480464 | Genistein results in decreased expression of JUP mRNA | CTD | PMID:16705744 PMID:16474171 | genistein | decreases expression | ISO | RGD:732396 | 6480464 | Genistein results in decreased expression of JUP mRNA | CTD | PMID:16474171 PMID:16705744 | N-nitrosodiethylamine | increases expression | ISO | RGD:620412 | 6480464 | Diethylnitrosamine results in increased expression of JUP mRNA | CTD | PMID:12807726 | ozone | multiple interactions | ISO | RGD:620412 | 6480464 | [Ozone co-treated with Chlorine] results in decreased expression of JUP mRNA | CTD | PMID:18636392 | paracetamol | affects expression | ISO | RGD:620412 | 6480464 | Acetaminophen affects the expression of JUP mRNA | CTD | PMID:19784758 | paracetamol | increases expression | ISO | RGD:620412 | 6480464 | Acetaminophen results in increased expression of JUP mRNA | CTD | PMID:19784758 | paracetamol | decreases expression | ISO | RGD:620412 | 6480464 | Acetaminophen results in decreased expression of JUP mRNA | CTD | PMID:19784758 | phenobarbital | decreases expression | ISO | RGD:620412 | 6480464 | Phenobarbital results in decreased expression of JUP mRNA | CTD | PMID:12807726 | phosgene | affects expression | EXP | | 6480464 | Phosgene affects the expression of JUP mRNA | CTD | PMID:16300373 | pirinixic acid | multiple interactions | ISO | RGD:732396 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of JUP mRNA | CTD | PMID:19710929 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of JUP mRNA | CTD | PMID:17426115 | progesterone | affects expression | EXP | | 6480464 | Progesterone affects the expression of JUP mRNA | CTD | PMID:17251523 | resveratrol | multiple interactions | ISO | RGD:732396 | 6480464 | [Coumestrol co-treated with resveratrol] results in decreased expression of JUP mRNA | CTD | PMID:19167446 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:732396 | 6480464 | tert-Butylhydroperoxide results in decreased expression of JUP mRNA | CTD | PMID:15336504 | thioacetamide | increases expression | ISO | RGD:620412 | 6480464 | Thioacetamide results in increased expression of JUP mRNA | CTD | PMID:19784758 | trans-resveratrol | multiple interactions | ISO | RGD:732396 | 6480464 | [Coumestrol co-treated with resveratrol] results in decreased expression of JUP mRNA | CTD | PMID:19167446 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of JUP mRNA | CTD | PMID:19448997 | trimellitic anhydride | decreases expression | EXP | | 6480464 | trimellitic anhydride results in decreased expression of JUP mRNA | CTD | PMID:16141432 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Acute myeloid leukemia |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | |
| Pathways in cancer | |
| Transcriptional misregulation in cancer | |
| Pathway Interaction Database | E-cadherin signaling events (PID:200113) |
| E-cadherin signaling in keratinocytes (PID:200147) | |
| E-cadherin signaling in the nascent adherens junction (PID:200124) | |
| N-cadherin signaling events (PID:200209) | |
| Posttranslational regulation of adherens junction stability and dissassembly (PID:200117) | |
Phenotype Annotations
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References - curated| 1. |
Aberle H, etal., Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6384-8. |
| 2. |
Baumgart E, etal., Clin Cancer Res. 2007 Mar 15;13(6):1685-94. |
| 3. |
Breault JE, etal., Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):557-64. |
| 4. |
Buchner A, etal., Anticancer Res. 1998 Nov-Dec;18(6A):4231-5. |
| 5. |
Bukholm IR, etal., Pathology. 2006 Oct;38(5):403-7. |
| 6. |
Gillett CE, etal., J Pathol. 2001 Apr;193(4):433-41. |
| 7. |
Imai T, etal., Hum Pathol. 2004 Dec;35(12):1469-76. |
| 8. |
McKoy G, etal., Lancet. 2000 Jun 17;355(9221):2119-24. |
| 9. |
MGD data from the GO Consortium |
| 10. |
MGD IEA |
| 11. |
Moreno-Bueno G, etal., J Pathol. 2003 Apr;199(4):471-8. |
| 12. |
Morita N, etal., Br J Cancer. 1999 Apr;79(11-12):1879-83. |
| 13. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 14. |
Pashmforoush M, etal., Nat Med 2001 May;7(5):591-7. |
| 15. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 16. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 17. |
RGD automated import pipeline |
| 18. |
RGD automated import pipeline for gene-chemical interactions |
| 19. |
RGD Automated Pipelines |
| 20. |
Robles-Frias A, etal., Acta Cytol. 2006 Mar-Apr;50(2):151-7. |
| 21. |
Ruiz P, etal., J Cell Biol 1996 Oct;135(1):215-25. |
| 22. |
San Miguel Fraile P, etal., Actas Urol Esp. 2007 Apr;31(4):355-60. |
| 23. |
Sato H, etal., Genomics 1999 Mar 15;56(3):303-9. |
| 24. |
Shiina H, etal., Cancer Res. 2001 Oct 1;61(19):7101-9. |
| 25. |
Shiina H, etal., Cancer Res. 2005 Mar 15;65(6):2130-8. |
| 26. |
Skotheim RI, etal., Cancer Res. 2002 Apr 15;62(8):2359-64. |
| 27. |
Skotheim RI, etal., Neoplasia. 2003 Sep-Oct;5(5):397-404. |
References - uncurated| PubMed | 10349636 |
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| 10769039 | |
| 10922068 | |
| 11013085 | |
| 11042159 | |
| 11076861 | |
| 11217851 | |
| 11371349 | |
| 11544199 | |
| 11669375 | |
| 11781569 | |
| 11878758 | |
| 12052883 | |
| 12112462 | |
| 12477932 | |
| 12847106 | |
| 14579029 | |
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| 1639851 | |
| 16418220 | |
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| 20093627 | |
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| 22036570 | |
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| 22479204 | |
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| 23108156 | |
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| 2726765 | |
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RGD Disease Portals| Jup has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Jup (Mus musculus) |
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| JUP (Homo sapiens) |
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| Jup (Rattus norvegicus) |
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Position Markers| AW545708 |
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| RH125427 |
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| Jup |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_010593 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01095749 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01095750 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK086401 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK145895 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK170934 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK171501 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL590968 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC040757 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC094461 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CD555608 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466662 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CS673476 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CS690859 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FB665612 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GM706824 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M90365 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_010593 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_034723 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_034723 | (Get FASTA) |
| GenBank Protein | AAB02885 | (Get FASTA) |
| AAH40757 | (Get FASTA) | |
| AAH94461 | (Get FASTA) | |
| BAE42126 | (Get FASTA) | |
| CAP07505 | (Get FASTA) | |
| CAP11473 | (Get FASTA) | |
| CAR97087 | (Get FASTA) | |
| CAT82325 | (Get FASTA) | |
| EDL02564 | (Get FASTA) | |
| Q02257 | (Get FASTA) |
Promoters| RGD ID: | 6821130 | ||||||||||
| Promoter ID: | MM_KWN:9773 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Brain, Kidney, Lung | ||||||||||
| Transcripts: | OTTMUST00000014201, OTTMUST00000014204 | ||||||||||
| Position: |
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| RGD ID: | 6821132 | ||||||||||
| Promoter ID: | MM_KWN:9774 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Brain, Kidney | ||||||||||
| Transcripts: | OTTMUST00000014203 | ||||||||||
| Position: |
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| RGD ID: | 6846851 | ||||||||||
| Promoter ID: | MM_ACW:8887 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Brain, ES_Cell, Kidney, Lung | ||||||||||
| Transcripts: | JUP.ESEP07, JUP.HSEP07 | ||||||||||
| Position: |
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| RGD ID: | 6821131 | ||||||||||
| Promoter ID: | MM_KWN:9775 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Brain, Kidney, Liver, Lung | ||||||||||
| Transcripts: | OTTMUST00000014202 | ||||||||||
| Position: |
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| RGD ID: | 6821133 | ||||||||||
| Promoter ID: | MM_KWN:9776 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Kidney, Lung | ||||||||||
| Transcripts: | OTTMUST00000014206, OTTMUST00000014207 | ||||||||||
| Position: |
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| RGD ID: | 6821128 | ||||||||||
| Promoter ID: | MM_KWN:9777 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day3, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen | ||||||||||
| Transcripts: | ENSMUST00000001592, ENSMUST00000107403, OTTMUST00000014205 | ||||||||||
| Position: |
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| RGD ID: | 6886028 | ||||||||||
| Promoter ID: | EPDNEW_M6465 | ||||||||||
| Type: | preliminary | ||||||||||
| Name: | Jup_1 | ||||||||||
| Description: | junction plakoglobin | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000001552 | |
| Entrez Gene | 16480 | ENTREZGENE |
| Gene3D-CATH | ARM-like | UniProtKB/Swiss-Prot |
| Germonline | ENSMUSG00000001552 | |
| HomoloGene Group ID | 1680 | ENTREZGENE |
| InterPro | ARM-like | UniProtKB/Swiss-Prot |
| ARM-type_fold | UniProtKB/Swiss-Prot | |
| Armadillo | UniProtKB/Swiss-Prot | |
| Beta-catenin | UniProtKB/Swiss-Prot | |
| IPI | IPI00229475 | UniProtKB/Swiss-Prot |
| KEGG Report | mmu:16480 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:96650 | ENTREZGENE |
| Pfam | Arm | UniProtKB/Swiss-Prot |
| PharmGKB | JUP | RGD |
| PRINTS | BCATNINFAMLY | UniProtKB/Swiss-Prot |
| PROSITE | ARM_REPEAT | UniProtKB/Swiss-Prot |
| SMART | ARM | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | ARM-type_fold | UniProtKB/Swiss-Prot |
| UniGene | Mm.299774 | ENTREZGENE |
| UniProt | PLAK_MOUSE | UniProtKB/Swiss-Prot |
| More on Jup | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 732397 |
| Created: | 2004-01-12 |
| Species: | Mus musculus |
| Last Modified: | 2013-03-19 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




