Gene: Fyn (Fyn proto-oncogene)  Mus musculus Symbol: Fyn Name: Fyn proto-oncogene Description: ENCODES a protein that exhibits ion channel binding; protein kinase activity; protein tyrosine kinase activity; INVOLVED IN activated T cell proliferation; cell surface receptor signaling pathway; dendrite morphogenesis; PARTICIPATES IN E-cadherin signaling pathway; eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH abnormal alpha-beta intraepithelial T cell morphology; abnormal B cell differentiation; abnormal CD4-positive T cell physiology; ASSOCIATED WITH Alzheimer Disease (ortholog); Burns (ortholog); Epilepsy, Temporal Lobe (ortholog); FOUND IN endosome (ortholog); intracellular membrane-bounded organelle (ortholog); membrane (ortholog); INTERACTS WITH 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; aflatoxin B1; benzo[a]pyrene Type: protein-coding RefSeq Status: VALIDATED Also known as: AI448320; AW552119; MGC115870; OTTMUSP00000046777; OTTMUSP00000046778; OTTMUSP00000046779; OTTMUSP00000046780; OTTMUSP00000046781; OTTMUSP00000046784; p59-Fyn; proto-oncogene c-Fyn; proto-oncogene tyrosine-protein kinase Fyn; Src Kinase p59; tyrosine-protein kinase Fyn Orthologs: Homo sapiens : FYN (FYN oncogene related to SRC, FGR, YES)  HGNC Rattus norvegicus : Fyn (FYN oncogene related to SRC, FGR, YES) Latest Assembly: Mouse Genome Assembly Build 37 Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 10 39,369,799 - 39,565,381 + NCBI Mouse cM Map 10 20.51   NCBI Mouse Celera Assembly 10 40,254,667 - 40,450,960 + NCBI Mouse Genome Assembly Build 37 10 39,089,605 - 39,285,187 + NCBI Mouse Genome Assembly Build 36.1 10 39,089,892 - 39,285,187 + NCBI Mouse Cytogenetic Map 10 B1   NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Alzheimer Disease   ISS RGD:731929 1358600   RGD   Alzheimer Disease   ISS   1358602   RGD   Burns   ISS RGD:2641 2324864 protein:decreased phosphorylation, decreased activity:T cell (rat) RGD   Epilepsy, Temporal Lobe   ISS RGD:2641 5147998 protein:increased expression:forebrain, postsynaptic density RGD   Schizophrenia   ISS RGD:731929 1358593   RGD   Sepsis   ISS RGD:2641 2324866 protein:decreased phosphorylation, decreased activity:T cell (rat) RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:731929 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FYN mRNA CTD PMID:22079256 (S)-nicotine multiple interactions ISO RGD:731929 6480464 Nicotine results in increased phosphorylation of and results in increased activity of FYN protein; more ... CTD PMID:17709503 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions EXP   6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FYN mRNA; more ... CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression EXP   6480464 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FYN mRNA CTD PMID:20230807 17beta-estradiol multiple interactions ISO RGD:731929 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FYN mRNA CTD PMID:19619570 17beta-estradiol increases expression ISO RGD:731929 6480464 Estradiol results in increased expression of FYN mRNA CTD PMID:19619570 17beta-estradiol decreases expression ISO RGD:731929 6480464 Estradiol results in decreased expression of FYN mRNA CTD PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:731929 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FYN mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:2641 6480464 Tetrachlorodibenzodioxin affects the expression of FYN mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:731929 6480464 Tetrachlorodibenzodioxin results in decreased expression of FYN mRNA CTD PMID:19619570 2-arachidonoylglycerol multiple interactions ISO RGD:2641 6480464 FYN gene mutant form inhibits the reaction [2-arachidonylglycerol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; more ... CTD PMID:12657697 2-methylcholine affects expression ISO RGD:731929 6480464 beta-methylcholine affects the expression of FYN mRNA CTD PMID:21179406 5-aza-2'-deoxycytidine affects expression ISO RGD:731929 6480464 decitabine affects the expression of FYN mRNA; more ... CTD PMID:18337055 5-aza-2'-deoxycytidine increases expression ISO RGD:731929 6480464 decitabine results in increased expression of FYN mRNA CTD PMID:16367923 PMID:19151715 5-aza-2'-deoxycytidine increases expression ISO RGD:731929 6480464 decitabine results in increased expression of FYN mRNA CTD PMID:19151715 PMID:16367923 5-azacytidine increases expression ISO RGD:731929 6480464 Azacitidine results in increased expression of FYN mRNA CTD PMID:21245298 5-fluorouracil affects response to substance ISO RGD:731929 6480464 FYN protein affects the susceptibility to Fluorouracil CTD PMID:16217747 aflatoxin B1 affects expression ISO RGD:731929 6480464 Aflatoxin B1 affects the expression of FYN protein CTD PMID:20106945 aflatoxin B1 decreases expression ISO RGD:731929 6480464 Aflatoxin B1 results in decreased expression of FYN mRNA CTD PMID:22100608 aflatoxin B1 decreases expression EXP   6480464 Aflatoxin B1 results in decreased expression of FYN mRNA CTD PMID:19770486 alachlor increases expression ISO RGD:2641 6480464 alachlor results in increased expression of FYN mRNA CTD PMID:12419858 all-trans-retinoic acid decreases expression ISO RGD:731929 6480464 Tretinoin results in decreased expression of FYN mRNA CTD PMID:21934132 all-trans-retinoic acid decreases expression ISO RGD:731929 6480464 Tretinoin results in decreased expression of FYN mRNA CTD PMID:21934132 PMID:15498508 all-trans-retinoic acid decreases expression ISO RGD:731929 6480464 Tretinoin results in decreased expression of FYN mRNA CTD PMID:15498508 PMID:21934132 ammonium chloride affects expression ISO RGD:2641 6480464 Ammonium Chloride affects the expression of FYN mRNA CTD PMID:16483693 benzo[a]pyrene decreases expression EXP   6480464 Benzo(a)pyrene results in decreased expression of FYN mRNA CTD PMID:19770486 benzo[a]pyrene decreases expression ISO RGD:731929 6480464 Benzo(a)pyrene results in decreased expression of FYN mRNA CTD PMID:20106945 PMID:20064835 benzo[a]pyrene multiple interactions EXP   6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of FYN mRNA CTD PMID:21715664 benzo[a]pyrene decreases expression ISO RGD:731929 6480464 Benzo(a)pyrene results in decreased expression of FYN mRNA CTD PMID:20064835 PMID:20106945 bis(2-chloroethyl) sulfide decreases expression EXP   6480464 Mustard Gas results in decreased expression of FYN mRNA CTD PMID:15674843 caffeine multiple interactions EXP   6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FYN mRNA; more ... CTD PMID:20230807 carmustine decreases expression ISO RGD:731929 6480464 Carmustine results in decreased expression of FYN mRNA CTD PMID:15980968 chromium(6+) increases activity ISO RGD:731929 6480464 chromium hexavalent ion results in increased activity of FYN protein; more ... CTD PMID:19994902 chromium(6+) multiple interactions ISO RGD:731929 6480464 FYN protein promotes the reaction [chromium hexavalent ion results in increased expression of IRF7 mRNA]; more ... CTD PMID:19994902 cisplatin decreases expression ISO RGD:731929 6480464 Cisplatin results in decreased expression of FYN mRNA CTD PMID:19561079 copper atom increases phosphorylation EXP   6480464 Copper results in increased phosphorylation of FYN protein CTD PMID:21172064 copper atom multiple interactions EXP   6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of FYN mRNA CTD PMID:15467011 copper atom multiple interactions ISO RGD:731929 6480464 [NSC 689534 binds to Copper] which results in increased expression of FYN mRNA CTD PMID:20971185 copper(0) increases phosphorylation EXP   6480464 Copper results in increased phosphorylation of FYN protein CTD PMID:21172064 copper(0) multiple interactions EXP   6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of FYN mRNA CTD PMID:15467011 copper(0) multiple interactions ISO RGD:731929 6480464 [NSC 689534 binds to Copper] which results in increased expression of FYN mRNA CTD PMID:20971185 copper(2+) sulfate increases expression ISO RGD:731929 6480464 Copper Sulfate results in increased expression of FYN mRNA CTD PMID:19549813 cyanidin 3-O-beta-D-glucoside multiple interactions EXP   6480464 cyanidin 3-O-glucoside inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased activity of FYN protein]; more ... CTD PMID:21501596 cyanidin 3-O-beta-D-glucoside affects binding EXP   6480464 cyanidin 3-O-glucoside binds to FYN protein CTD PMID:21501596 cyclophosphamide increases expression ISO RGD:731929 6480464 Cyclophosphamide results in increased expression of FYN mRNA CTD PMID:17403535 cyclosporin A decreases expression ISO RGD:731929 6480464 Cyclosporine results in decreased expression of FYN mRNA CTD PMID:20106945 cyclosporin A increases expression EXP   6480464 Cyclosporine results in increased expression of FYN mRNA CTD PMID:19770486 cytarabine increases expression ISO RGD:731929 6480464 Cytarabine results in increased expression of FYN mRNA CTD PMID:21198554 D-gluconic acid decreases expression ISO RGD:2641 6480464 gluconic acid results in decreased expression of FYN mRNA CTD PMID:16556975 dasatinib (anhydrous) affects binding ISO RGD:731929 6480464 dasatinib binds to FYN protein CTD PMID:18180381 Delta(9)-tetrahydrocannabinol increases response to substance EXP   6480464 FYN results in increased susceptibility to Tetrahydrocannabinol CTD PMID:12657697 dieldrin increases activity ISO RGD:2641 6480464 Dieldrin results in increased activity of FYN protein CTD PMID:21801747 dieldrin multiple interactions ISO RGD:2641 6480464 FYN protein promotes the reaction [Dieldrin results in increased phosphorylation of PRKCD protein]; more ... CTD PMID:21801747 ethanol increases phosphorylation ISO RGD:731929 6480464 Ethanol results in increased phosphorylation of FYN protein CTD PMID:18182400 ethanol multiple interactions ISO RGD:731929 6480464 sodium arsenite promotes the reaction [Ethanol results in increased phosphorylation of FYN protein] CTD PMID:18182400 etoposide affects response to substance ISO RGD:731929 6480464 FYN protein affects the susceptibility to Etoposide CTD PMID:16217747 haloperidol multiple interactions EXP   6480464 FYN gene mutant form inhibits the reaction [Haloperidol results in increased phosphorylation of GRIN2B protein] CTD PMID:16407246 haloperidol increases phosphorylation EXP   6480464 Haloperidol results in increased phosphorylation of FYN protein CTD PMID:16407246 haloperidol affects response to substance EXP   6480464 FYN protein affects the susceptibility to Haloperidol CTD PMID:16407246 hydrogen peroxide affects localization EXP   6480464 Hydrogen Peroxide affects the localization of FYN protein CTD PMID:21690096 hydrogen peroxide multiple interactions EXP   6480464 [[Hydrogen Peroxide affects the localization of FYN protein] which results in increased phosphorylation of NFE2L2 protein] which affects the localization of and affects the degradation of NFE2L2 protein; more ... CTD PMID:21690096 lead diacetate multiple interactions ISO RGD:2641 6480464 FYN protein affects the reaction [lead acetate results in decreased expression of PDGFRA protein] CTD PMID:17298174 lead diacetate increases activity ISO RGD:2641 6480464 lead acetate results in increased activity of FYN protein CTD PMID:17298174 lead(0) multiple interactions ISO RGD:2641 6480464 FYN protein affects the reaction [Lead results in decreased expression of PDGFRA protein] CTD PMID:17298174 lead(0) increases activity ISO RGD:2641 6480464 Lead results in increased activity of FYN protein CTD PMID:17298174 lithium chloride multiple interactions EXP   6480464 [[Lithium Chloride results in decreased activity of GSK3B protein] which affects the localization of FYN protein] which affects the localization of NFE2L2 protein CTD PMID:21690096 mitomycin C affects response to substance ISO RGD:731929 6480464 FYN protein affects the susceptibility to Mitomycin CTD PMID:16217747 mitoxantrone affects response to substance ISO RGD:731929 6480464 FYN protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO RGD:731929 6480464 Methylnitronitrosoguanidine results in increased expression of FYN mRNA CTD PMID:12634122 nickel sulfate increases expression ISO RGD:731929 6480464 nickel sulfate results in increased expression of FYN mRNA CTD PMID:16780908 paracetamol affects expression EXP   6480464 Acetaminophen affects the expression of FYN mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:731929 6480464 Acetaminophen results in increased expression of FYN mRNA CTD PMID:22230336 paraquat multiple interactions ISO RGD:2641 6480464 FYN protein affects the reaction [Paraquat results in decreased expression of PDGFRA protein] CTD PMID:17298174 paraquat affects expression ISO RGD:2641 6480464 Paraquat affects the expression of FYN mRNA CTD PMID:15206577 paraquat increases activity ISO RGD:2641 6480464 Paraquat results in increased activity of FYN protein CTD PMID:17298174 phenobarbital multiple interactions EXP   6480464 NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of FYN mRNA] CTD PMID:19482888 phenobarbital decreases expression EXP   6480464 Phenobarbital results in decreased expression of FYN mRNA CTD PMID:19482888 pirinixic acid multiple interactions EXP   6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FYN mRNA CTD PMID:19710929 piroxicam decreases expression ISO RGD:731929 6480464 Piroxicam results in decreased expression of FYN mRNA CTD PMID:21858171 resveratrol affects localization ISO RGD:731929 6480464 resveratrol affects the localization of FYN protein CTD PMID:21467134 resveratrol multiple interactions ISO RGD:731929 6480464 resveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of FYN protein] CTD PMID:21467134 silver atom multiple interactions EXP   6480464 Silver inhibits the reaction [GDNF protein results in increased activity of FYN protein] CTD PMID:20488942 silver(0) multiple interactions EXP   6480464 Silver inhibits the reaction [GDNF protein results in increased activity of FYN protein] CTD PMID:20488942 tamibarotene decreases expression ISO RGD:731929 6480464 Am 80 results in decreased expression of FYN mRNA; more ... CTD PMID:15498508 trans-resveratrol affects localization ISO RGD:731929 6480464 resveratrol affects the localization of FYN protein CTD PMID:21467134 trans-resveratrol multiple interactions ISO RGD:731929 6480464 resveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of FYN protein] CTD PMID:21467134 valproic acid affects expression EXP   6480464 Valproic Acid affects the expression of FYN mRNA CTD PMID:17292431 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) activated T cell proliferation   IMP MGI:MGI:2179145 2290270 MGI:MGI:2148425|PMID:1516132 MGI MGI:MGI:2148425 PMID:1516132 cell surface receptor signaling pathway   IDA   2290270 MGI:MGI:87805|PMID:9177270 MGI MGI:MGI:87805 PMID:9177270 dendrite morphogenesis   IMP MGI:MGI:1930480 2290270 MGI:MGI:3621856|PMID:12372285 MGI MGI:MGI:3621856 PMID:12372285 detection of mechanical stimulus involved in sensory perception of pain   IMP MGI:MGI:1930480 2290270 MGI:MGI:3604261|PMID:16190898 MGI MGI:MGI:3604261 PMID:16190898 forebrain development   IGI MGI:MGI:98397 2290270 MGI:MGI:3590439|PMID:16162939 MGI MGI:MGI:3590439 PMID:16162939 forebrain development   IMP MGI:MGI:98397 2290270 MGI:MGI:3610430|PMID:15073522 MGI MGI:MGI:3610430 PMID:15073522 multicellular organismal development   IEA UniProtKB-KW:KW-0217 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 myelination   TAS   2290270 MGI:MGI:2158591|PMID:11826099 MGI MGI:MGI:2158591 PMID:11826099 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 negative regulation of gene expression   IMP   2290270 MGI:MGI:4850200|PMID:20978343 BHF-UCL MGI:MGI:4850200 PMID:20978343 negative regulation of protein catabolic process   IMP   2290270 MGI:MGI:3775717|PMID:16841086 MGI MGI:MGI:3775717 PMID:16841086 neuron migration   IGI MGI:MGI:98397 2290270 MGI:MGI:3590439|PMID:16162939 MGI MGI:MGI:3590439 PMID:16162939 neuron migration   IMP MGI:MGI:1930480 2290270 MGI:MGI:3610430|PMID:15073522 MGI MGI:MGI:3610430 PMID:15073522 peptidyl-tyrosine phosphorylation   IDA   2290270 MGI:MGI:1859033|PMID:10872802 MGI MGI:MGI:1859033 PMID:10872802 peptidyl-tyrosine phosphorylation   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 peptidyl-tyrosine phosphorylation   IDA   2290270 MGI:MGI:65996|PMID:8175795 MGI MGI:MGI:65996 PMID:8175795 peptidyl-tyrosine phosphorylation   IMP MGI:MGI:1857172 2290270 MGI:MGI:3768467|PMID:17923684 MGI MGI:MGI:3768467 PMID:17923684 peptidyl-tyrosine phosphorylation   IDA   2290270 MGI:MGI:3768467|PMID:17923684 MGI MGI:MGI:3768467 PMID:17923684 peptidyl-tyrosine phosphorylation   IMP MGI:MGI:1930480 2290270 MGI:MGI:1098368|PMID:9381182 MGI MGI:MGI:1098368 PMID:9381182 peptidyl-tyrosine phosphorylation   IDA   2290270 MGI:MGI:66781|PMID:8196616 MGI MGI:MGI:66781 PMID:8196616 phosphorylation   IEA UniProtKB-KW:KW-0418 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 positive regulation of neuron projection development   IGI MGI:MGI:98247 2290270 MGI:MGI:3778100|PMID:18354028 MGI MGI:MGI:3778100 PMID:18354028 protein autophosphorylation   IDA   2290270 MGI:MGI:65996|PMID:8175795 MGI MGI:MGI:65996 PMID:8175795 protein autophosphorylation   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein phosphorylation   IMP MGI:MGI:1930480 2290270 MGI:MGI:3604261|PMID:16190898 MGI MGI:MGI:3604261 PMID:16190898 protein phosphorylation   IEA EC:2.7.10.2 2290270 MGI:MGI:2152096 GOC MGI:MGI:2152096 protein phosphorylation   IMP MGI:MGI:1930480 2290270 MGI:MGI:1330707|PMID:9892651 MGI MGI:MGI:1330707 PMID:9892651 regulation of cell shape   IDA   2290270 MGI:MGI:2158591|PMID:11826099 MGI MGI:MGI:2158591 PMID:11826099 response to ethanol   IGI MGI:MGI:95819 2290270 MGI:MGI:1098368|PMID:9381182 MGI MGI:MGI:1098368 PMID:9381182 T cell receptor signaling pathway   ISO UniProtKB:P06241 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytoplasm   IEA UniProtKB-KW:KW-0963 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 endosome   ISO UniProtKB:P06241 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 intracellular membrane-bounded organelle   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 membrane   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 mitochondrion   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 nucleus   IEA UniProtKB-KW:KW-0539 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 plasma membrane   ISO UniProtKB:P06241 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 postsynaptic density   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) ATP binding   IEA InterPro:IPR000719|InterPro:IPR017441 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 ATP binding   IEA UniProtKB-KW:KW-0067 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 CD4 receptor binding   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 CD8 receptor binding   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 ephrin receptor binding   ISO UniProtKB:P06241 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 glycoprotein binding   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 glycoprotein binding   ISO UniProtKB:P06241 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 identical protein binding   ISO UniProtKB:P06241 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 ion channel binding   IPI UniProtKB:Q9EPK8 2290270 MGI:MGI:2653708|PMID:12538589 BHF-UCL MGI:MGI:2653708 PMID:12538589 kinase activity   IEA UniProtKB-KW:KW-0418 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 metal ion binding   IEA UniProtKB-KW:KW-0479 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 non-membrane spanning protein tyrosine kinase activity   IEA EC:2.7.10.2 2290270 MGI:MGI:2152096 UniProtKB MGI:MGI:2152096 nucleotide binding   IEA UniProtKB-KW:KW-0547 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 peptide hormone receptor binding   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 phosphatidylinositol 3-kinase binding   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein binding   IPI UniProtKB:Q9JIA7 2290270 MGI:MGI:3843433|PMID:16316995 IntAct MGI:MGI:3843433 PMID:16316995 protein binding   IPI UniProtKB:Q8BP71 2290270 MGI:MGI:892764|PMID:9185665 MGI MGI:MGI:892764 PMID:9185665 protein binding   IPI UniProtKB:P61979 2290270 MGI:MGI:892764|PMID:9185665 MGI MGI:MGI:892764 PMID:9185665 protein binding   IPI UniProtKB:Q9QX47 2290270 MGI:MGI:892764|PMID:9185665 MGI MGI:MGI:892764 PMID:9185665 protein binding   IPI UniProtKB:A2A6A1 2290270 MGI:MGI:892764|PMID:9185665 MGI MGI:MGI:892764 PMID:9185665 protein binding   IPI UniProtKB:P51807|UniProtKB:Q60749 2290270 MGI:MGI:3688344|PMID:15102471 IntAct MGI:MGI:3688344 PMID:15102471 protein binding   IPI UniProtKB:P49710 2290270 MGI:MGI:3694161|PMID:10713104 UniProtKB MGI:MGI:3694161 PMID:10713104 protein binding   IPI UniProtKB:P22646 2290270 MGI:MGI:66781|PMID:8196616 MGI MGI:MGI:66781 PMID:8196616 protein binding   IPI UniProtKB:O88689 2290270 MGI:MGI:1267132|PMID:9655502 MGI MGI:MGI:1267132 PMID:9655502 protein binding   IPI UniProtKB:O75051|UniProtKB:P49619 2290270 MGI:MGI:3621856|PMID:12372285 MGI MGI:MGI:3621856 PMID:12372285 protein binding   IPI UniProtKB:Q80W68 2290270 MGI:MGI:3768467|PMID:17923684 MGI MGI:MGI:3768467 PMID:17923684 protein binding   IPI UniProtKB:Q60749 2290270 MGI:MGI:893273|PMID:7799925 UniProtKB MGI:MGI:893273 PMID:7799925 protein complex binding   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein kinase activity   IDA   2290270 MGI:MGI:2158591|PMID:11826099 MGI MGI:MGI:2158591 PMID:11826099 protein kinase activity   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein tyrosine kinase activity   IDA   2290270 MGI:MGI:3768467|PMID:17923684 MGI MGI:MGI:3768467 PMID:17923684 protein tyrosine kinase activity   ISO UniProtKB:P06241 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 protein tyrosine kinase activity   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein tyrosine kinase activity   IDA   2290270 MGI:MGI:65996|PMID:8175795 MGI MGI:MGI:65996 PMID:8175795 protein tyrosine kinase activity   IDA   2290270 MGI:MGI:3775717|PMID:16841086 MGI MGI:MGI:3775717 PMID:16841086 protein tyrosine kinase activity   IDA   2290270 MGI:MGI:66781|PMID:8196616 MGI MGI:MGI:66781 PMID:8196616 protein tyrosine kinase activity   IDA   2290270 MGI:MGI:1859033|PMID:10872802 MGI MGI:MGI:1859033 PMID:10872802 receptor binding   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 T cell receptor binding   ISO UniProtKB:Q62844 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 transferase activity   IEA UniProtKB-KW:KW-0808 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 transferase activity, transferring phosphorus-containing groups   IEA InterPro:IPR011009 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 tubulin binding   IDA   2290270 MGI:MGI:2158591|PMID:11826099 MGI MGI:MGI:2158591 PMID:11826099 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) altered Reelin signaling pathway   TAS   2324970   RGD   E-cadherin signaling pathway   ISO RGD:731929 6484113   PID PID:200147 eicosanoid signaling pathway   ISO RGD:731929 6484113   PID PID:200082 ephrin - ephrin receptor bidirectional signaling axis   ISO RGD:731929 6484113   PID PID:200204 ephrin - ephrin receptor bidirectional signaling axis   ISO RGD:731929 6484113   PID PID:200142 ephrin - ephrin receptor bidirectional signaling axis   ISO RGD:731929 6484113   PID PID:200059 glypican signaling pathway   ISO RGD:731929 6484113   PID PID:200026 interleukin-2 signaling pathway   ISO RGD:731929 6484113   PID PID:200098 measles infection pathway   IEA RGD:731930 6907045   KEGG mmu:05162 myocarditis pathway   IEA RGD:731930 6907045   KEGG mmu:05416 phosphatidylinositol 3-kinase class I signaling pathway   ISO RGD:731929 6484113   PID PID:200116 platelet-derived growth factor signaling pathway   ISO RGD:731929 6484113   PID PID:200149 prion diseases pathway   IEA RGD:731930 6907045   KEGG mmu:05020 protein kinase C (PKC) signaling pathway   ISS RGD:731929 5131492   RGD   Reelin signaling pathway   TAS   2324970   RGD   Reelin signaling pathway   ISO RGD:731929 6484113   PID PID:200062 syndecan signaling pathway   ISO RGD:731929 6484113   PID PID:200198 T cell receptor signaling pathway   IEA RGD:731930 6907045   KEGG mmu:04660 vascular endothelial growth factor signaling pathway   ISS RGD:731929 2298729   RGD   vascular endothelial growth factor signaling pathway   ISO RGD:731929 6484113   PID PID:200188 External Database Links KEGG Pathway Adherens junction Axon guidance Cholinergic synapse Fc epsilon RI signaling pathway Focal adhesion Measles Natural killer cell mediated cytotoxicity Osteoclast differentiation Prion diseases T cell receptor signaling pathway Viral myocarditis Pathway Interaction Database Alpha-synuclein signaling (PID:200219) amb2 Integrin signaling (PID:200127) Angiopoietin receptor Tie2-mediated signaling (PID:200079) Class I PI3K signaling events (PID:200116) CXCR4-mediated signaling events (PID:200099) E-cadherin signaling in keratinocytes (PID:200147) EPHA forward signaling (PID:200142) Ephrin A reverse signaling (PID:200059) Ephrin B reverse signaling (PID:200204) ErbB4 signaling events (PID:200011) Fc-epsilon receptor I signaling in mast cells (PID:200004) Glypican 1 network (PID:200026) IL2-mediated signaling events (PID:200098) Nephrin/Neph1 signaling in the kidney podocyte (PID:200152) Netrin-mediated signaling events (PID:200088) PDGFR-beta signaling pathway (PID:200149) Posttranslational regulation of adherens junction stability and dissassembly (PID:200117) Reelin signaling pathway (PID:200062) Regulation of p38-alpha and p38-beta (PID:200066) Signaling events mediated by focal adhesion kinase (PID:200224) Signaling events mediated by PTP1B (PID:200042) Signaling events mediated by VEGFR1 and VEGFR2 (PID:200188) Syndecan-3-mediated signaling events (PID:200198) TCR signaling in naïve CD4+ T cells (PID:200027) TCR signaling in naïve CD8+ T cells (PID:200075) Thromboxane A2 receptor signaling (PID:200082) Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) abnormal alpha-beta intraepithelial T cell morphology   IAGP   5509061   MGI PMID:9045930 abnormal B cell differentiation   IAGP   5509061   MGI PMID:12563261 abnormal CD4-positive T cell physiology   IAGP   5509061   MGI PMID:15539156 abnormal chemokine level   IAGP   5509061   MGI PMID:12239221 abnormal circadian rhythm   IAGP   5509061   MGI PMID:10869499 abnormal cytokine secretion   IAGP   5509061   MGI PMID:15902435 abnormal dentate gyrus morphology   IAGP   5509061   MGI PMID:7958873 abnormal dentate gyrus morphology   IAGP   5509061   MGI PMID:9114065 abnormal dentate gyrus morphology   IAGP   5509061   MGI PMID:1361685 abnormal eosinophil physiology   IAGP   5509061   MGI PMID:11306441 abnormal excitatory postsynaptic potential   IAGP   5509061   MGI PMID:9381182 abnormal hippocampus layer morphology   IAGP   5509061   MGI PMID:8264796 abnormal hippocampus morphology   IAGP   5509061   MGI PMID:7958873 abnormal hippocampus morphology   IAGP   5509061   MGI PMID:9114065 abnormal hippocampus pyramidal cell layer   IAGP   5509061   MGI PMID:1361685 abnormal hippocampus pyramidal cell layer   IAGP   5509061   MGI PMID:9114065 abnormal hippocampus pyramidal cell morphology   IAGP   5509061   MGI PMID:1361685 abnormal hippocampus pyramidal cell morphology   IAGP   5509061   MGI PMID:9114065 abnormal hypothalamus morphology   IAGP   5509061   MGI PMID:10869499 abnormal immune cell physiology   IAGP   5509061   MGI PMID:1387588 abnormal interleukin secretion   IAGP   5509061   MGI PMID:15902435 abnormal interleukin-4 secretion   IAGP   5509061   MGI PMID:11306441 abnormal kidney morphology   IAGP   5509061   MGI PMID:7958873 abnormal macrophage physiology   IAGP   5509061   MGI PMID:12239221 abnormal maternal nurturing   IAGP   5509061   MGI PMID:15154672 abnormal motor capabilities/coordination/movement   IAGP   5509061   MGI PMID:10489260 abnormal myelination   IAGP   5509061   MGI PMID:7509042 abnormal myelination   IAGP   5509061   MGI PMID:11245687 abnormal NK cell physiology   IAGP   5509061   MGI PMID:22683124 abnormal NK T cell number   IAGP   5509061   MGI PMID:8934570 abnormal nursing   IAGP   5509061   MGI PMID:7958873 abnormal olfaction   IAGP   5509061   MGI PMID:15154672 abnormal olfactory bulb morphology   IAGP   5509061   MGI PMID:8264796 abnormal optic nerve morphology   IAGP   5509061   MGI PMID:11245687 abnormal pro-B cell differentiation   IAGP   5509061   MGI PMID:12563261 abnormal pup retrieval   IAGP   5509061   MGI PMID:15154672 abnormal regulatory T cell physiology   IAGP   5509061   MGI PMID:19668367 abnormal renal glomerulus morphology   IAGP   5509061   MGI PMID:7958873 abnormal renal tubule morphology   IAGP   5509061   MGI PMID:7958873 abnormal seminiferous tubule morphology   IAGP   5509061   MGI PMID:11751285 abnormal serotonin level   IAGP   5509061   MGI PMID:11834300 abnormal Sertoli cell morphology   IAGP   5509061   MGI PMID:11751285 abnormal somatosensory cortex morphology   IAGP   5509061   MGI PMID:15073522 abnormal spatial learning   IAGP   5509061   MGI PMID:1361685 abnormal startle reflex   IAGP   5509061   MGI PMID:11834300 abnormal stratification in cerebral cortex   IAGP   5509061   MGI PMID:15073522 abnormal suckling behavior   IAGP   5509061   MGI PMID:8264796 abnormal T cell activation   IAGP   5509061   MGI PMID:1516132 abnormal T cell clonal deletion   IAGP   5509061   MGI PMID:1387588 abnormal T cell differentiation   IAGP   5509061   MGI PMID:8562954 abnormal T cell physiology   IAGP   5509061   MGI PMID:1387588 abnormal T cell proliferation   IAGP   5509061   MGI PMID:15539156 abnormal thymocyte activation   IAGP   5509061   MGI PMID:1387588 abnormal thymocyte activation   IAGP   5509061   MGI PMID:1516132 abnormal thymus cortex morphology   IAGP   5509061   MGI PMID:8562954 absent CD4-positive T cells   IAGP   5509061   MGI PMID:8934570 absent CD8-positive T cells   IAGP   5509061   MGI PMID:8934570 absent T cells   IAGP   5509061   MGI PMID:8934569 arrested B cell differentiation   IAGP   5509061   MGI PMID:12563261 arrested T cell differentiation   IAGP   5509061   MGI PMID:8934569 arrested T cell differentiation   IAGP   5509061   MGI PMID:8934570 audiogenic seizures   IAGP   5509061   MGI PMID:7723633 complete postnatal lethality   IAGP   5509061   MGI PMID:7958873 cortical renal glomerulopathies   IAGP   5509061   MGI PMID:7958873 decreased B cell number   IAGP   5509061   MGI PMID:12563261 decreased body size   IAGP   5509061   MGI PMID:7958873 decreased body weight   IAGP   5509061   MGI PMID:7958873 decreased corpus callosum size   IAGP   5509061   MGI PMID:11245687 decreased double-positive T cell number   IAGP   5509061   MGI PMID:8562954 decreased double-positive T cell number   IAGP   5509061   MGI PMID:8934570 decreased gamma-delta intraepithelial T cell number   IAGP   5509061   MGI PMID:8934570 decreased gamma-delta intraepithelial T cell number   IAGP   5509061   MGI PMID:9045930 decreased gamma-delta T cell number   IAGP   5509061   MGI PMID:8934569 decreased IgE level   IAGP   5509061   MGI PMID:15539156 decreased IgE level   IAGP   5509061   MGI PMID:11306441 decreased immature B cell number   IAGP   5509061   MGI PMID:12563261 decreased interferon-gamma secretion   IAGP   5509061   MGI PMID:22683124 decreased interleukin-2 secretion   IAGP   5509061   MGI PMID:1387588 decreased interleukin-2 secretion   IAGP   5509061   MGI PMID:11306441 decreased pre-B cell number   IAGP   5509061   MGI PMID:12563261 decreased regulatory T cell number   IAGP   5509061   MGI PMID:19668367 decreased T cell number   IAGP   5509061   MGI PMID:8934569 decreased T cell proliferation   IAGP   5509061   MGI PMID:1387588 decreased T cell proliferation   IAGP   5509061   MGI PMID:19668367 decreased T cell proliferation   IAGP   5509061   MGI PMID:1516132 decreased testis weight   IAGP   5509061   MGI PMID:11751285 decreased thymocyte number   IAGP   5509061   MGI PMID:8562954 ectopic hippocampus pyramidal cells   IAGP   5509061   MGI PMID:9114065 enhanced behavioral response to alcohol   IAGP   5509061   MGI PMID:9381182 enhanced passive avoidance behavior   IAGP   5509061   MGI PMID:7877449 enlarged lymph nodes   IAGP   5509061   MGI PMID:19668367 enlarged spleen   IAGP   5509061   MGI PMID:7958873 extramedullary hematopoiesis   IAGP   5509061   MGI PMID:7958873 glomerulosclerosis   IAGP   5509061   MGI PMID:7958873 increased dopamine level   IAGP   5509061   MGI PMID:11834300 increased fear-related response   IAGP   5509061   MGI PMID:11834300 increased fear-related response   IAGP   5509061   MGI PMID:7877449 increased hippocampus pyramidal cell number   IAGP   5509061   MGI PMID:1361685 increased IgG2a level   IAGP   5509061   MGI PMID:1387588 increased IgM level   IAGP   5509061   MGI PMID:1387588 increased interleukin-5 secretion   IAGP   5509061   MGI PMID:11306441 increased regulatory T cell number   IAGP   5509061   MGI PMID:19668367 increased sensitivity to xenobiotic induced morbidity/mortality   IAGP   5509061   MGI PMID:15154672 increased spleen white pulp amount   IAGP   5509061   MGI PMID:7958873 increased susceptibility to experimental autoimmune uveoretinitis   IAGP   5509061   MGI PMID:15902435 increased susceptibility to type I hypersensitivity reaction   IAGP   5509061   MGI PMID:11306441 increased T cell number   IAGP   5509061   MGI PMID:19668367 increased tumor necrosis factor secretion   IAGP   5509061   MGI PMID:15902435 increased urine protein level   IAGP   5509061   MGI PMID:7958873 myeloid hyperplasia   IAGP   5509061   MGI PMID:7958873 oligozoospermia   IAGP   5509061   MGI PMID:11751285 partial postnatal lethality   IAGP   5509061   MGI PMID:7958873 premature death   IAGP   5509061   MGI PMID:10489260 prolonged circadian period   IAGP   5509061   MGI PMID:10869499 reduced female fertility   IAGP   5509061   MGI PMID:7958873 reduced long term potentiation   IAGP   5509061   MGI PMID:1361685 reduced long term potentiation   IAGP   5509061   MGI PMID:9114065 ruffled hair   IAGP   5509061   MGI PMID:7958873 small kidney   IAGP   5509061   MGI PMID:7958873 small seminiferous tubules   IAGP   5509061   MGI PMID:11751285 thymus atrophy   IAGP   5509061   MGI PMID:8562954 thymus hypoplasia   IAGP   5509061   MGI PMID:8934569 thymus hypoplasia   IAGP   5509061   MGI PMID:8934570 tonic seizures   IAGP   5509061   MGI PMID:10489260 weight loss   IAGP   5509061   MGI PMID:7958873 Disease Annotations Alzheimer Disease  (ISS) Burns  (ISS) Epilepsy, Temporal Lobe  (ISS) Schizophrenia  (ISS) Sepsis  (ISS) Gene-Chemical Interaction Annotations (-)-epigallocatechin 3-gallate  (ISO) (S)-nicotine  (ISO) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP) 17beta-estradiol  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (ISO) 2-arachidonoylglycerol  (ISO) 2-methylcholine  (ISO) 5-aza-2'-deoxycytidine  (ISO) 5-azacytidine  (ISO) 5-fluorouracil  (ISO) aflatoxin B1  (EXP,ISO) alachlor  (ISO) all-trans-retinoic acid  (ISO) ammonium chloride  (ISO) benzo[a]pyrene  (EXP,ISO) bis(2-chloroethyl) sulfide  (EXP) caffeine  (EXP) carmustine  (ISO) chromium(6+)  (ISO) cisplatin  (ISO) copper atom  (EXP,ISO) copper(0)  (EXP,ISO) copper(2+) sulfate  (ISO) cyanidin 3-O-beta-D-glucoside  (EXP) cyclophosphamide  (ISO) cyclosporin A  (EXP,ISO) cytarabine  (ISO) D-gluconic acid  (ISO) dasatinib (anhydrous)  (ISO) Delta(9)-tetrahydrocannabinol  (EXP) dieldrin  (ISO) ethanol  (ISO) etoposide  (ISO) haloperidol  (EXP) hydrogen peroxide  (EXP) lead diacetate  (ISO) lead(0)  (ISO) lithium chloride  (EXP) mitomycin C  (ISO) mitoxantrone  (ISO) N-methyl-N'-nitro-N-nitrosoguanidine  (ISO) nickel sulfate  (ISO) paracetamol  (EXP,ISO) paraquat  (ISO) phenobarbital  (EXP) pirinixic acid  (EXP) piroxicam  (ISO) resveratrol  (ISO) silver atom  (EXP) silver(0)  (EXP) tamibarotene  (ISO) trans-resveratrol  (ISO) valproic acid  (EXP) Gene Ontology Annotations Biological Process activated T cell proliferation  (IMP) cell surface receptor signaling pathway  (IDA) dendrite morphogenesis  (IMP) detection of mechanical stimulus involved in sensory perception of pain  (IMP) forebrain development  (IGI,IMP) multicellular organismal development  (IEA) myelination  (TAS) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO) negative regulation of gene expression  (IMP) negative regulation of protein catabolic process  (IMP) neuron migration  (IGI,IMP) peptidyl-tyrosine phosphorylation  (IDA,IMP,ISO) phosphorylation  (IEA) positive regulation of neuron projection development  (IGI) protein autophosphorylation  (IDA,ISO) protein phosphorylation  (IEA,IMP) regulation of cell shape  (IDA) response to ethanol  (IGI) T cell receptor signaling pathway  (ISO) Cellular Component cytoplasm  (IEA) endosome  (ISO) intracellular membrane-bounded organelle  (ISO) membrane  (ISO) mitochondrion  (ISO) nucleus  (IEA) plasma membrane  (ISO) postsynaptic density  (ISO) Molecular Function ATP binding  (IEA) CD4 receptor binding  (ISO) CD8 receptor binding  (ISO) ephrin receptor binding  (ISO) glycoprotein binding  (ISO) identical protein binding  (ISO) ion channel binding  (IPI) kinase activity  (IEA) metal ion binding  (IEA) non-membrane spanning protein tyrosine kinase activity  (IEA) nucleotide binding  (IEA) peptide hormone receptor binding  (ISO) phosphatidylinositol 3-kinase binding  (ISO) protein binding  (IPI) protein complex binding  (ISO) protein kinase activity  (IDA,ISO) protein tyrosine kinase activity  (IDA,ISO) receptor binding  (ISO) T cell receptor binding  (ISO) transferase activity  (IEA) transferase activity, transferring phosphorus-containing groups  (IEA) tubulin binding  (IDA) Molecular Pathway Annotations altered Reelin signaling pathway  (TAS) E-cadherin signaling pathway  (ISO) eicosanoid signaling pathway  (ISO) ephrin - ephrin receptor bidirectional signaling axis  (ISO) glypican signaling pathway  (ISO) interleukin-2 signaling pathway  (ISO) measles infection pathway  (IEA) myocarditis pathway  (IEA) phosphatidylinositol 3-kinase class I signaling pathway  (ISO) platelet-derived growth factor signaling pathway  (ISO) prion diseases pathway  (IEA) protein kinase C (PKC) signaling pathway  (ISS) Reelin signaling pathway  (ISO,TAS) syndecan signaling pathway  (ISO) T cell receptor signaling pathway  (IEA) vascular endothelial growth factor signaling pathway  (ISO,ISS) External Database Links KEGG Pathway Adherens junction Axon guidance Cholinergic synapse Fc epsilon RI signaling pathway Focal adhesion Measles Natural killer cell mediated cytotoxicity Osteoclast differentiation Prion diseases T cell receptor signaling pathway Viral myocarditis Pathway Interaction Database Alpha-synuclein signaling (PID:200219) amb2 Integrin signaling (PID:200127) Angiopoietin receptor Tie2-mediated signaling (PID:200079) Class I PI3K signaling events (PID:200116) CXCR4-mediated signaling events (PID:200099) E-cadherin signaling in keratinocytes (PID:200147) EPHA forward signaling (PID:200142) Ephrin A reverse signaling (PID:200059) Ephrin B reverse signaling (PID:200204) ErbB4 signaling events (PID:200011) Fc-epsilon receptor I signaling in mast cells (PID:200004) Glypican 1 network (PID:200026) IL2-mediated signaling events (PID:200098) Nephrin/Neph1 signaling in the kidney podocyte (PID:200152) Netrin-mediated signaling events (PID:200088) PDGFR-beta signaling pathway (PID:200149) Posttranslational regulation of adherens junction stability and dissassembly (PID:200117) Reelin signaling pathway (PID:200062) Regulation of p38-alpha and p38-beta (PID:200066) Signaling events mediated by focal adhesion kinase (PID:200224) Signaling events mediated by PTP1B (PID:200042) Signaling events mediated by VEGFR1 and VEGFR2 (PID:200188) Syndecan-3-mediated signaling events (PID:200198) TCR signaling in naïve CD4+ T cells (PID:200027) TCR signaling in naïve CD8+ T cells (PID:200075) Thromboxane A2 receptor signaling (PID:200082) Phenotype Annotations abnormal alpha-beta intraepithelial T cell morphology  (IAGP) abnormal B cell differentiation  (IAGP) abnormal CD4-positive T cell physiology  (IAGP) abnormal chemokine level  (IAGP) abnormal circadian rhythm  (IAGP) abnormal cytokine secretion  (IAGP) abnormal dentate gyrus morphology  (IAGP) abnormal eosinophil physiology  (IAGP) abnormal excitatory postsynaptic potential  (IAGP) abnormal hippocampus layer morphology  (IAGP) abnormal hippocampus morphology  (IAGP) abnormal hippocampus pyramidal cell layer  (IAGP) abnormal hippocampus pyramidal cell morphology  (IAGP) abnormal hypothalamus morphology  (IAGP) abnormal immune cell physiology  (IAGP) abnormal interleukin secretion  (IAGP) abnormal interleukin-4 secretion  (IAGP) abnormal kidney morphology  (IAGP) abnormal macrophage physiology  (IAGP) abnormal maternal nurturing  (IAGP) abnormal motor capabilities/coordination/movement  (IAGP) abnormal myelination  (IAGP) abnormal NK cell physiology  (IAGP) abnormal NK T cell number  (IAGP) abnormal nursing  (IAGP) abnormal olfaction  (IAGP) abnormal olfactory bulb morphology  (IAGP) abnormal optic nerve morphology  (IAGP) abnormal pro-B cell differentiation  (IAGP) abnormal pup retrieval  (IAGP) abnormal regulatory T cell physiology  (IAGP) abnormal renal glomerulus morphology  (IAGP) abnormal renal tubule morphology  (IAGP) abnormal seminiferous tubule morphology  (IAGP) abnormal serotonin level  (IAGP) abnormal Sertoli cell morphology  (IAGP) abnormal somatosensory cortex morphology  (IAGP) abnormal spatial learning  (IAGP) abnormal startle reflex  (IAGP) abnormal stratification in cerebral cortex  (IAGP) abnormal suckling behavior  (IAGP) abnormal T cell activation  (IAGP) abnormal T cell clonal deletion  (IAGP) abnormal T cell differentiation  (IAGP) abnormal T cell physiology  (IAGP) abnormal T cell proliferation  (IAGP) abnormal thymocyte activation  (IAGP) abnormal thymus cortex morphology  (IAGP) absent CD4-positive T cells  (IAGP) absent CD8-positive T cells  (IAGP) absent T cells  (IAGP) arrested B cell differentiation  (IAGP) arrested T cell differentiation  (IAGP) audiogenic seizures  (IAGP) complete postnatal lethality  (IAGP) cortical renal glomerulopathies  (IAGP) decreased B cell number  (IAGP) decreased body size  (IAGP) decreased body weight  (IAGP) decreased corpus callosum size  (IAGP) decreased double-positive T cell number  (IAGP) decreased gamma-delta intraepithelial T cell number  (IAGP) decreased gamma-delta T cell number  (IAGP) decreased IgE level  (IAGP) decreased immature B cell number  (IAGP) decreased interferon-gamma secretion  (IAGP) decreased interleukin-2 secretion  (IAGP) decreased pre-B cell number  (IAGP) decreased regulatory T cell number  (IAGP) decreased T cell number  (IAGP) decreased T cell proliferation  (IAGP) decreased testis weight  (IAGP) decreased thymocyte number  (IAGP) ectopic hippocampus pyramidal cells  (IAGP) enhanced behavioral response to alcohol  (IAGP) enhanced passive avoidance behavior  (IAGP) enlarged lymph nodes  (IAGP) enlarged spleen  (IAGP) extramedullary hematopoiesis  (IAGP) glomerulosclerosis  (IAGP) increased dopamine level  (IAGP) increased fear-related response  (IAGP) increased hippocampus pyramidal cell number  (IAGP) increased IgG2a level  (IAGP) increased IgM level  (IAGP) increased interleukin-5 secretion  (IAGP) increased regulatory T cell number  (IAGP) increased sensitivity to xenobiotic induced morbidity/mortality  (IAGP) increased spleen white pulp amount  (IAGP) increased susceptibility to experimental autoimmune uveoretinitis  (IAGP) increased susceptibility to type I hypersensitivity reaction  (IAGP) increased T cell number  (IAGP) increased tumor necrosis factor secretion  (IAGP) increased urine protein level  (IAGP) myeloid hyperplasia  (IAGP) oligozoospermia  (IAGP) partial postnatal lethality  (IAGP) premature death  (IAGP) prolonged circadian period  (IAGP) reduced female fertility  (IAGP) reduced long term potentiation  (IAGP) ruffled hair  (IAGP) small kidney  (IAGP) small seminiferous tubules  (IAGP) thymus atrophy  (IAGP) thymus hypoplasia  (IAGP) tonic seizures  (IAGP) weight loss  (IAGP) References - curated 1. Choudhry MA, etal., J Immunol. 1998 Jan 15;160(2):929-35. 2. Choudhry MA, etal., Shock. 2002 Sep;18(3):212-6. 3. Haefliger JA, etal., J Biol Chem 1992 Jan 25;267(3):2057-64. 4. Ho GJ, etal., Neurobiol Aging 2005 May;26(5):625-35. 5. Holmes K, etal., Cell Signal. 2007 Oct;19(10):2003-12. Epub 2007 Jun 12. 6. Lee G, etal., J Neurosci 2004 Mar 3;24(9):2304-12. 7. MGD and Homologene mouse data transfer 8. MGD data from the GO Consortium 9. MGD IEA 10. Ohnuma T, etal., Brain Res Mol Brain Res 2003 Apr 10;112(1-2):90-4. 11. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 12. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 13. Poole AW, etal., Trends Pharmacol Sci. 2004 Oct;25(10):528-35. 14. RGD automated import pipeline 15. RGD automated import pipeline for gene-chemical interactions 16. Tissir F and Goffinet AM, Nat Rev Neurosci. 2003 Jun;4(6):496-505. 17. Wyneken U, etal., Neuroscience. 2001;102(1):65-74. 18. Yagi T, etal., Nature 1993 Dec 23-30;366(6457):742-5. 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Biological Process Cancer Pathways Cardiovascular Pathways Diabetes Pathways Diabetes Phenotypes Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Immune and Inflammatory Phenotypes Biological Process Neurological Diseases Neurological Pathways Neurological Phenotypes Obesity Pathways Obesity Phenotypes Biological Process Respiratory Pathways Genomics Comparative Map Data Fyn   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 10 39,369,799 - 39,565,381 + NCBI Mouse cM Map 10 20.51   NCBI Mouse Celera Assembly 10 40,254,667 - 40,450,960 + NCBI Mouse Genome Assembly Build 37 10 39,089,605 - 39,285,187 + NCBI Mouse Genome Assembly Build 36.1 10 39,089,892 - 39,285,187 + NCBI Mouse Cytogenetic Map 10 B1   NCBI FYN   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 6 111,979,477 - 112,192,561 - NCBI Human Genome Assembly HuRef 6 109,554,123 - 109,767,060 - NCBI Human Genome Assembly GRCh37 6 111,981,535 - 112,194,655 - NCBI Human Genome Assembly Build 36 6 112,089,178 - 112,301,320 - NCBI Human Cytogenetic Map 6 q21   NCBI Human Genome Assembly 6 112,089,179 - 112,186,978   NCBI Fyn   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 20 q13   NCBI RGSC Genome Assembly v5.0 20 46,161,060 - 46,352,027 + NCBI RGSC Genome Assembly v3.4 20 43,501,853 - 43,695,567 + NCBI Rat Celera Assembly 20 43,482,980 - 43,675,123 + NCBI Genome Assembly 3.1 20 43,524,863 - 43,718,578 + NCBI Position Markers AW552119   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 10 39,564,883 - 39,564,977   UniSTS Mouse cM Map 10 25.0   UniSTS Mouse Celera Assembly 10 40,450,462 - 40,450,556   UniSTS Mouse Genome Assembly Build 37 10 39,284,689 - 39,284,783   UniSTS Mouse Cytogenetic Map 10 B1   UniSTS 18.MMHAP85FRF9.seq   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 10 39,421,139 - 39,421,304   UniSTS Mouse cM Map 10 25.0   UniSTS Mouse Celera Assembly 10 40,306,068 - 40,306,233   UniSTS Mouse Genome Assembly Build 37 10 39,140,945 - 39,141,110   UniSTS Mouse Cytogenetic Map 10 B1   UniSTS AI448320   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 10 39,565,003 - 39,565,113   UniSTS Mouse cM Map 10 25.0   UniSTS Mouse Celera Assembly 10 40,450,582 - 40,450,692   UniSTS Mouse Genome Assembly Build 37 10 39,284,809 - 39,284,919   UniSTS Mouse Cytogenetic Map 10 B1   UniSTS Fyn   Map Chr Position Strand Source Mouse cM Map 10 25.0   UniSTS Mouse Cytogenetic Map 10 B1   UniSTS PMC317175P1   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 10 39,512,557 - 39,512,805   UniSTS Mouse cM Map 10 25.0   UniSTS Mouse Celera Assembly 10 40,398,118 - 40,398,366   UniSTS Mouse Genome Assembly Build 37 10 39,232,363 - 39,232,611   UniSTS Mouse Cytogenetic Map 10 B1   UniSTS QTLs in Region (Mouse Genome Assembly Build 37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 4142209 Psrs1_m psoriasis susceptibility 1 (mouse) Not determined 10 7317969 41318122 Mouse 1558865 Lith21_m lithogenic gene 21 (mouse) Not determined 10 8368911 42369034 Mouse 4141080 Bfsz2_m barrel field size 2 (mouse) Not determined 10 11871992 45872234 Mouse 4141594 Fbtq4_m femoral bone trait QTL 4 (mouse) Not determined 10 11871992 45872234 Mouse 1300898 Cfid_m cystic fibrosis intestinal distress (mouse) Not determined 10 29564113 63564193 Mouse 1301520 Uvbi1_m UVB induced immunosuppression 1 (mouse) Not determined 10 30818209 64818340 Mouse 1357558 Bmch4_m bone mechanical trait 4 (mouse) Not determined 10 31420846 65420994 Mouse 1300907 Daq4_m directional asymmetry QTL 4 (mouse) Not determined 10 34337110 68337258 Mouse 1300588 Daq5_m directional asymmetry QTL 5 (mouse) Not determined 10 34337110 68337258 Mouse Sequence Nucleotide Sequences Nucleotide RefSeqs NM_001122892 (Get FASTA) Search GEO for Microarray Profiles   NM_001122893 (Get FASTA) Search GEO for Microarray Profiles   NM_008054 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AAHY01084875 (Get FASTA) Search GEO for Microarray Profiles   AAHY01084876 (Get FASTA) Search GEO for Microarray Profiles   AAHY01084877 (Get FASTA) Search GEO for Microarray Profiles   AAHY01084878 (Get FASTA) Search GEO for Microarray Profiles   AAHY01084879 (Get FASTA) Search GEO for Microarray Profiles   AAHY01084880 (Get FASTA) Search GEO for Microarray Profiles   AAHY01084881 (Get FASTA) Search GEO for Microarray Profiles   AC153422 (Get FASTA) Search GEO for Microarray Profiles   AC153537 (Get FASTA) Search GEO for Microarray Profiles   AK040199 (Get FASTA) Search GEO for Microarray Profiles   AK156584 (Get FASTA) Search GEO for Microarray Profiles   AK171646 (Get FASTA) Search GEO for Microarray Profiles   AK178286 (Get FASTA) Search GEO for Microarray Profiles   AK179168 (Get FASTA) Search GEO for Microarray Profiles   AK181277 (Get FASTA) Search GEO for Microarray Profiles   AK185949 (Get FASTA) Search GEO for Microarray Profiles   AK188892 (Get FASTA) Search GEO for Microarray Profiles   AK192068 (Get FASTA) Search GEO for Microarray Profiles   AK197042 (Get FASTA) Search GEO for Microarray Profiles   AK211878 (Get FASTA) Search GEO for Microarray Profiles   AK216658 (Get FASTA) Search GEO for Microarray Profiles   BC010554 (Get FASTA) Search GEO for Microarray Profiles   BC032149 (Get FASTA) Search GEO for Microarray Profiles   BC092217 (Get FASTA) Search GEO for Microarray Profiles   BE952821 (Get FASTA) Search GEO for Microarray Profiles   BF662030 (Get FASTA) Search GEO for Microarray Profiles   BQ179147 (Get FASTA) Search GEO for Microarray Profiles   BQ714273 (Get FASTA) Search GEO for Microarray Profiles   CH466540 (Get FASTA) Search GEO for Microarray Profiles   M27266 (Get FASTA) Search GEO for Microarray Profiles   U70324 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_008054 RefSeq Status: VALIDATED Type: CODING Protein Acc Id: NP_032080 Peptide Label: isoform b Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 10 39,369,799 - 39,565,381 + ENTREZGENE Mouse cM Map 10   + ENTREZGENE Mouse Celera Assembly 10 40,254,667 - 40,450,960 + RGD Mouse Genome Assembly Build 37 10 39,089,605 - 39,285,187 + RGD RefSeq Acc Id: NM_001122892 RefSeq Status: VALIDATED Type: CODING Protein Acc Id: NP_001116364 Peptide Label: isoform b Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 10 39,369,799 - 39,565,381 + ENTREZGENE Mouse cM Map 10   + ENTREZGENE Mouse Celera Assembly 10 40,254,667 - 40,450,960 + RGD Mouse Genome Assembly Build 37 10 39,089,605 - 39,285,187 + RGD RefSeq Acc Id: NM_001122893 RefSeq Status: VALIDATED Type: CODING Protein Acc Id: NP_001116365 Peptide Label: isoform a Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 10 39,369,799 - 39,565,381 + ENTREZGENE Mouse cM Map 10   + ENTREZGENE Mouse Celera Assembly 10 40,254,667 - 40,450,960 + RGD Mouse Genome Assembly Build 37 10 39,089,605 - 39,285,187 + RGD Protein Sequences Protein RefSeqs NP_001116364 (Get FASTA)   NP_001116365 (Get FASTA)   NP_032080 (Get FASTA) GenBank Protein AAA37644 (Get FASTA)   AAB09568 (Get FASTA)   AAH32149 (Get FASTA)   AAH92217 (Get FASTA)   BAE33766 (Get FASTA)   BAE42585 (Get FASTA)   EDL04921 (Get FASTA)   EDL04922 (Get FASTA)   EDL04923 (Get FASTA)   EDL04924 (Get FASTA)   P39688 (Get FASTA) Promoters RGD ID: 6819509 Promoter ID: MM_KWN:3926 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen Transcripts: LINCRNA_103,   NM_001122892,   OTTMUST00000086386,   OTTMUST00000086387,   UC007EVZ.1 Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 10 39,089,279 - 39,089,779 - MPROMDB RGD ID: 6884070 Promoter ID: EPDNEW_M5486 Type: preliminary Name: Fyn_1 Description: Fyn proto-oncogene SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 10 39,089,596 - 39,089,656   EPDNEW RGD ID: 6819301 Promoter ID: MM_KWN:3930 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: BoneMarrow_2Hour,   Brain Transcripts: OTTMUST00000086393 Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 10 39,230,561 - 39,231,777 + MPROMDB RGD ID: 6819299 Promoter ID: MM_KWN:3931 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: Kidney Transcripts: OTTMUST00000086394 Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 10 39,252,026 - 39,252,526 + MPROMDB Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSMUSG00000019843 ENTREZGENE Ensembl Protein ENSMUSP00000057707 ENTREZGENE   ENSMUSP00000097547 ENTREZGENE Ensembl Transcript ENSMUST00000063091 ENTREZGENE   ENSMUST00000099967 ENTREZGENE Entrez Gene 14360 ENTREZGENE Gene3D-CATH SH2 UniProtKB/Swiss-Prot Germonline ENSMUSG00000019843 HomoloGene Group ID 48068 ENTREZGENE InterPro Kinase-like_dom UniProtKB/Swiss-Prot   Prot_kinase_cat_dom UniProtKB/Swiss-Prot   Protein_kinase_ATP_BS UniProtKB/Swiss-Prot   Ser-Thr/Tyr_kinase UniProtKB/Swiss-Prot   SH2 UniProtKB/Swiss-Prot   SH3_domain UniProtKB/Swiss-Prot   Tyr_kinase_AS UniProtKB/Swiss-Prot   Tyr_kinase_cat_dom UniProtKB/Swiss-Prot IPI IPI00322097 UniProtKB/Swiss-Prot   IPI00762435 UniProtKB/Swiss-Prot   IPI00927961 UniProtKB/TrEMBL   IPI00927997 UniProtKB/TrEMBL   IPI00928410 UniProtKB/TrEMBL KEGG Report mmu:14360 ENTREZGENE, UniProtKB/Swiss-Prot MGD MGI:95602 ENTREZGENE Pfam Pkinase_Tyr UniProtKB/Swiss-Prot   SH2 UniProtKB/Swiss-Prot   SH3_1 UniProtKB/Swiss-Prot PRINTS SH2DOMAIN UniProtKB/Swiss-Prot   SH3DOMAIN UniProtKB/Swiss-Prot   TYRKINASE UniProtKB/Swiss-Prot PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot   PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot   PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot   SH2 UniProtKB/Swiss-Prot   SH3 UniProtKB/Swiss-Prot SMART SH2 UniProtKB/Swiss-Prot   SH3 UniProtKB/Swiss-Prot   TyrKc UniProtKB/Swiss-Prot Superfamily-SCOP Kinase_like UniProtKB/Swiss-Prot   SH3 UniProtKB/Swiss-Prot UniGene Mm.4848 ENTREZGENE UniProt D3YVZ0_MOUSE UniProtKB/TrEMBL   D3YZ57_MOUSE UniProtKB/TrEMBL   D3YZA2_MOUSE UniProtKB/TrEMBL   FYN_MOUSE UniProtKB/Swiss-Prot

More on Fyn Entrez Gene Ensembl Gene Genome Browser MGI Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 731930 Created: 2004-01-12 Species: Mus musculus Last Modified: 2013-04-23 Status: ACTIVE