Hmgcs1 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1) - Rat Genome Database

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Gene: Hmgcs1 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1) Mus musculus
Analyze
Symbol: Hmgcs1
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
RGD ID: 731474
MGI Page MGI
Description: Predicted to enable several functions, including hydroxymethylglutaryl-CoA synthase activity; organic acid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including acetyl-CoA metabolic process; cellular response to low-density lipoprotein particle stimulus; and farnesyl diphosphate biosynthetic process, mevalonate pathway. Predicted to act upstream of or within cholesterol biosynthetic process. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-hydroxy-3-methylglutaryl coenzyme A synthase; B130032C06Rik; HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase, cytoplasmic; MGC36662; MGC98430
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913120,151,887 - 120,169,796 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13120,151,915 - 120,169,796 (+)EnsemblGRCm39 Ensembl
GRCm3813119,690,351 - 119,708,260 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13119,690,379 - 119,708,260 (+)EnsemblGRCm38mm10GRCm38
Celera13124,068,495 - 124,086,131 (+)NCBICelera
Cytogenetic Map13D2.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-benzylpiperazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-D  (EXP)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
Acetyl tributyl citrate  (EXP)
Actein  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP,ISO)
betulin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (ISO)
bupropion  (ISO)
butan-1-ol  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
celastrol  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
citalopram  (ISO)
clofibrate  (ISO)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
dexamethasone  (ISO)
Di-n-hexyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dicyclohexyl phthalate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
difenoconazole  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dipentyl phthalate  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP,ISO)
enilconazole  (EXP)
enniatin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenarimol  (ISO)
fenofibrate  (EXP)
fentin chloride  (ISO)
fenvalerate  (ISO)
fingolimod hydrochloride  (ISO)
fluoranthene  (EXP)
fluoxetine  (ISO)
flusilazole  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
Ganoderic acid A  (EXP,ISO)
gedunin  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
glyphosate  (EXP)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
imipramine  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
isobutanol  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
itraconazole  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP,ISO)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lead(0)  (ISO)
lead(II) chloride  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (EXP)
lucanthone  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
miconazole  (EXP)
mirtazapine  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
morphine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
octocrylene  (ISO)
olanzapine  (ISO)
oleic acid  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (EXP,ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
phlorizin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (EXP)
phytosterols  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP)
prednisolone  (ISO)
progesterone  (ISO)
propamocarb  (EXP)
propanal  (ISO)
propanil  (ISO)
propiconazole  (ISO)
prostaglandin A1  (EXP)
pyrazinecarboxamide  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
succimer  (EXP)
sulfadimethoxine  (ISO)
sulfluramid  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
tebuconazole  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
topiramate  (ISO)
topotecan  (ISO)
triadimefon  (EXP,ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
Triptolide  (EXP)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zileuton  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
ziprasidone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Transcriptional regulation of mitochondrial HMG-CoA synthase in the control of ketogenesis. Hegardt FG Biochimie. 1998 Oct;80(10):803-6.
2. Proteomic and transcriptomic analysis for streptozotocin-induced diabetic rat pancreas in response to fungal polysaccharide treatments. Kim SW, etal., Proteomics. 2008 Jun;8(11):2344-61.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Cerebral ketone body metabolism. Morris AA J Inherit Metab Dis. 2005;28(2):109-21.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. The effects of the intestinal glucosidase inhibitor acarbose on cholesterogenesis in corpulent rats. Tulp OL, etal., Comp Biochem Physiol A Comp Physiol. 1991;100(3):763-8.
12. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
13. Proteomic profiling of proteins in rat spinal cord induced by contusion injury. Yan X, etal., Neurochem Int. 2010 Jul;56(8):971-83. Epub 2010 Apr 24.
Additional References at PubMed
PMID:7803821   PMID:7907092   PMID:8827514   PMID:8833906   PMID:10349636   PMID:10512203   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932  
PMID:12520002   PMID:12904583   PMID:14610273   PMID:14662765   PMID:14681479   PMID:14722362   PMID:15489334   PMID:15782199   PMID:15840001   PMID:16141072   PMID:16141073   PMID:16498401  
PMID:17967808   PMID:18023262   PMID:18799693   PMID:20059953   PMID:21873635   PMID:22496890   PMID:23136395   PMID:23604909   PMID:24146773   PMID:24154525   PMID:25147951   PMID:26108225  
PMID:26685326   PMID:27689697   PMID:28031458   PMID:28489004   PMID:29899135   PMID:30333137   PMID:32325033   PMID:34321999   PMID:34599818   PMID:35830813   PMID:36417873   PMID:37541847  
PMID:38042368   PMID:38355793  


Genomics

Comparative Map Data
Hmgcs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913120,151,887 - 120,169,796 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13120,151,915 - 120,169,796 (+)EnsemblGRCm39 Ensembl
GRCm3813119,690,351 - 119,708,260 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13119,690,379 - 119,708,260 (+)EnsemblGRCm38mm10GRCm38
Celera13124,068,495 - 124,086,131 (+)NCBICelera
Cytogenetic Map13D2.3NCBI
HMGCS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38543,287,470 - 43,313,412 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl543,287,470 - 43,313,512 (-)EnsemblGRCh38hg38GRCh38
GRCh37543,287,572 - 43,313,514 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36543,325,250 - 43,349,352 (-)NCBINCBI36Build 36hg18NCBI36
Build 34543,325,254 - 43,349,241NCBI
Celera543,180,430 - 43,204,721 (-)NCBICelera
Cytogenetic Map5p12NCBI
HuRef543,238,000 - 43,264,043 (-)NCBIHuRef
CHM1_1543,288,873 - 43,314,913 (-)NCBICHM1_1
T2T-CHM13v2.0543,540,305 - 43,566,247 (-)NCBIT2T-CHM13v2.0
Hmgcs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8253,379,457 - 53,399,807 (+)NCBIGRCr8
mRatBN7.2251,649,368 - 51,667,100 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl251,649,497 - 51,667,100 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx258,768,758 - 58,786,285 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0256,827,479 - 56,845,007 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0251,761,458 - 51,778,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0252,427,351 - 52,445,082 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl252,431,601 - 52,445,055 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0270,791,035 - 70,809,191 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4251,737,090 - 51,754,583 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1251,665,322 - 51,682,816 (+)NCBI
Celera247,304,535 - 47,322,038 (+)NCBICelera
Cytogenetic Map2q15NCBI
Hmgcs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544618,978,102 - 18,998,951 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544618,978,261 - 18,996,794 (+)NCBIChiLan1.0ChiLan1.0
HMGCS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2467,019,050 - 67,043,912 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1565,172,676 - 65,197,538 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0567,067,001 - 67,091,786 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1572,116,304 - 72,141,050 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl572,116,228 - 72,141,050 (+)Ensemblpanpan1.1panPan2
HMGCS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1466,633,706 - 66,654,005 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl466,633,572 - 66,652,196 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha466,394,617 - 66,415,022 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0467,130,232 - 67,144,820 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl467,123,795 - 67,144,508 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1466,884,796 - 66,905,197 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0467,014,391 - 67,034,791 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0467,551,264 - 67,571,669 (+)NCBIUU_Cfam_GSD_1.0
Hmgcs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213209,925,788 - 209,946,119 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648018,862,238 - 18,882,616 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648018,862,288 - 18,882,614 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGCS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1627,936,218 - 27,957,193 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11627,936,225 - 27,957,261 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21629,432,931 - 29,452,429 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HMGCS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1442,083,523 - 42,107,410 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl442,080,949 - 42,107,409 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607132,560,062 - 32,583,929 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmgcs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475911,826,876 - 11,847,111 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475911,826,793 - 11,847,111 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Hmgcs1
257 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:391
Count of miRNA genes:307
Interacting mature miRNAs:337
Transcripts:ENSMUST00000179869
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391965303120883175Mouse
1301142Heal2_mwound healing/regeneration 2 (mouse)Not determined1393875267120883175Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391383692120883175Mouse
1558763Gct9_mgranulosa cell tumorigenesis 9 (mouse)Not determined1395036824120883175Mouse
1357468Rplag_mreduced platelet aggregation (mouse)Not determined1395502130120883175Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386341617120341758Mouse
4142338Skmw18_mskeletal muscle weight 18 (mouse)Not determined1394528399120883175Mouse
4142400Tgq24_mtriglyceride QTL 24 (mouse)Not determined102602630120883175Mouse
12879496Fexq2_mfear expression QTL 2 (mouse)13100741519120883175Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse
14746974Manh75_mmandible shape 75 (mouse)1399386647120883175Mouse

Markers in Region
36.MHAa90g12.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813119,698,522 - 119,698,638UniSTSGRCm38
MGSCv3713104,617 - 104,733UniSTSGRCm37
MGSCv3713124,149 - 124,265UniSTSGRCm37
Celera13124,076,558 - 124,076,674UniSTS
Whitehead/MRC_RH131025.25UniSTS
Hmgcs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813119,707,287 - 119,708,177UniSTSGRCm38
MGSCv371395,078 - 95,968UniSTSGRCm37
MGSCv3713114,610 - 115,500UniSTSGRCm37
Celera13124,085,341 - 124,086,231UniSTS
cM Map1366.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001291439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006517578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ071929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000179869   ⟹   ENSMUSP00000136944
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13120,151,982 - 120,169,618 (+)Ensembl
GRCm38.p6 Ensembl13119,690,446 - 119,708,082 (+)Ensembl
RefSeq Acc Id: ENSMUST00000224188   ⟹   ENSMUSP00000153064
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13120,152,000 - 120,169,796 (+)Ensembl
GRCm38.p6 Ensembl13119,690,464 - 119,708,260 (+)Ensembl
RefSeq Acc Id: ENSMUST00000225543   ⟹   ENSMUSP00000153212
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13120,151,915 - 120,161,262 (+)Ensembl
GRCm38.p6 Ensembl13119,690,379 - 119,699,726 (+)Ensembl
RefSeq Acc Id: ENSMUST00000226092
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13120,151,998 - 120,163,722 (+)Ensembl
GRCm38.p6 Ensembl13119,690,462 - 119,702,186 (+)Ensembl
RefSeq Acc Id: NM_001291439   ⟹   NP_001278368
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913120,151,887 - 120,169,796 (+)NCBI
GRCm3813119,690,351 - 119,708,260 (+)NCBI
Celera13124,068,384 - 124,086,314 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145942   ⟹   NP_666054
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913120,151,887 - 120,169,796 (+)NCBI
GRCm3813119,690,351 - 119,708,260 (+)NCBI
Celera13124,068,384 - 124,086,314 (+)NCBI
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006517578   ⟹   XP_006517641
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913120,151,933 - 120,169,618 (+)NCBI
GRCm3813119,690,393 - 119,708,082 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157957   ⟹   XP_036013850
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913120,152,076 - 120,169,618 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_666054   ⟸   NM_145942
- UniProtKB: Q3UXI4 (UniProtKB/Swiss-Prot),   Q8JZK9 (UniProtKB/Swiss-Prot),   Q3UJ70 (UniProtKB/TrEMBL),   Q3UWQ9 (UniProtKB/TrEMBL),   Q8K0I5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006517641   ⟸   XM_006517578
- Peptide Label: isoform X2
- UniProtKB: Q3UXI4 (UniProtKB/Swiss-Prot),   Q8JZK9 (UniProtKB/Swiss-Prot),   Q3UJ70 (UniProtKB/TrEMBL),   Q3UWQ9 (UniProtKB/TrEMBL),   Q8K0I5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278368   ⟸   NM_001291439
- UniProtKB: Q3UXI4 (UniProtKB/Swiss-Prot),   Q8JZK9 (UniProtKB/Swiss-Prot),   Q3UJ70 (UniProtKB/TrEMBL),   Q3UWQ9 (UniProtKB/TrEMBL),   Q8K0I5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000153212   ⟸   ENSMUST00000225543
RefSeq Acc Id: ENSMUSP00000153064   ⟸   ENSMUST00000224188
RefSeq Acc Id: ENSMUSP00000136944   ⟸   ENSMUST00000179869
RefSeq Acc Id: XP_036013850   ⟸   XM_036157957
- Peptide Label: isoform X1
- UniProtKB: Q3UJ70 (UniProtKB/TrEMBL),   Q3UWQ9 (UniProtKB/TrEMBL),   Q8K0I5 (UniProtKB/TrEMBL)
Protein Domains
Hydroxymethylglutaryl-coenzyme A synthase C-   Hydroxymethylglutaryl-coenzyme A synthase N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8JZK9-F1-model_v2 AlphaFold Q8JZK9 1-520 view protein structure

Promoters
RGD ID:8681402
Promoter ID:EPDNEW_M18732
Type:initiation region
Name:Hmgcs1_1
Description:Mus musculus 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1, transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3813119,690,462 - 119,690,522EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107592 AgrOrtholog
Ensembl Genes ENSMUSG00000093930 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000179869 ENTREZGENE
  ENSMUST00000179869.3 UniProtKB/Swiss-Prot
  ENSMUST00000224188 ENTREZGENE
  ENSMUST00000224188.2 UniProtKB/Swiss-Prot
  ENSMUST00000225543.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HMG_CoA_synt_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_CoA_synt_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_CoA_synth_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_CoA_synthase_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiolase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:208715 UniProtKB/Swiss-Prot
MGD MGI:107592 ENTREZGENE
NCBI Gene 208715 ENTREZGENE
PANTHER 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HMG_CoA_synt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_CoA_synt_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hmgcs1 PhenoGen
PROSITE HMG_COA_SYNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286YDE3_MOUSE UniProtKB/TrEMBL
  HMCS1_MOUSE UniProtKB/Swiss-Prot
  Q3UJ70 ENTREZGENE, UniProtKB/TrEMBL
  Q3UJQ2_MOUSE UniProtKB/TrEMBL
  Q3UKE7_MOUSE UniProtKB/TrEMBL
  Q3UWQ9 ENTREZGENE, UniProtKB/TrEMBL
  Q3UXI4 ENTREZGENE
  Q8C5F4_MOUSE UniProtKB/TrEMBL
  Q8JZK9 ENTREZGENE
  Q8K0I5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q3UXI4 UniProtKB/Swiss-Prot