Hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)

Gene: Hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1) Chinchilla lanigera

Analyze

Symbol:

Hmgcs1

Name:

3-hydroxy-3-methylglutaryl-CoA synthase 1

RGD ID:

9035953

Description:

ENCODES a protein that exhibits hydroxymethylglutaryl-CoA synthase activity (ortholog); isomerase activity (ortholog); organic acid binding (ortholog); INVOLVED IN cellular response to cholesterol (ortholog); cellular response to follicle-stimulating hormone stimulus (ortholog); cellular response to low-density lipoprotein particle stimulus (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); Neurodevelopmental Disorders (ortholog); obesity (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); hydroxymethylglutaryl-CoA synthase, cytoplasmic

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955446	18,978,102 - 18,998,951 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955446	18,978,261 - 18,996,794 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Diabetes Mellitus (ISO)

Neurodevelopmental Disorders (ISO)

obesity (ISO)

rigid spine muscular dystrophy 1 (ISO)

Spinal Cord Compression (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to cholesterol (ISO)

cellular response to follicle-stimulating hormone stimulus (ISO)

cellular response to low-density lipoprotein particle stimulus (ISO)

cellular response to organic cyclic compound (ISO)

liver development (ISO)

male gonad development (ISO)

response to cholesterol (ISO)

response to gonadotropin (ISO)

response to hormone (ISO)

response to low light intensity stimulus (ISO)

response to organic cyclic compound (ISO)

response to purine-containing compound (ISO)

response to tellurium ion (ISO)

response to vitamin E (ISO)

response to xenobiotic stimulus (ISO)

Molecular Function

hydroxymethylglutaryl-CoA synthase activity (ISO)

isomerase activity (ISO)

organic acid binding (ISO)

protein homodimerization activity (ISO)

small molecule binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

alendronate pharmacodynamics pathway (ISO)

cholesterol biosynthetic pathway (ISO)

cholesterol ester storage disease pathway (ISO)

congenital hemidysplasia with ichthyosiform erythroderma and limb defects pathway (ISO)

desmosterolosis pathway (ISO)

forkhead class A signaling pathway (ISO)

hypercholesterolemia pathway (ISO)

ibandronate pharmacodynamics pathway (ISO)

ketone bodies biosynthetic pathway (ISO)

mevalonic aciduria pathway (ISO)

nitrogenous bisphosphonate pharmacodynamics pathway (ISO)

pamidronate pharmacodynamics pathway (ISO)

risedronate pharmacodynamics pathway (ISO)

Smith-Lemli-Opitz Syndrome pathway (ISO)

statin pharmacodynamics pathway (ISO)

Wolman disease pathway (ISO)

X-linked dominant chondrodysplasia punctata 2 pathway (ISO)

zoledronate pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Hmgcs1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955446	18,978,102 - 18,998,951 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955446	18,978,261 - 18,996,794 (+)	NCBI	ChiLan1.0	ChiLan1.0

HMGCS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	43,287,470 - 43,313,412 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	43,287,470 - 43,313,512 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	43,287,572 - 43,313,514 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	43,325,250 - 43,349,352 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	43,325,254 - 43,349,241	NCBI
Celera	5	43,180,430 - 43,204,721 (-)	NCBI		Celera
Cytogenetic Map	5	p12	NCBI
HuRef	5	43,238,000 - 43,264,043 (-)	NCBI		HuRef
CHM1_1	5	43,288,873 - 43,314,913 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	43,540,305 - 43,566,247 (-)	NCBI		T2T-CHM13v2.0

Hmgcs1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	120,151,887 - 120,169,796 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	120,151,915 - 120,169,796 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	119,690,351 - 119,708,260 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	119,690,379 - 119,708,260 (+)	Ensembl	GRCm38		mm10	GRCm38
Celera	13	124,068,495 - 124,086,131 (+)	NCBI		Celera
Cytogenetic Map	13	D2.3	NCBI

Hmgcs1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	53,379,457 - 53,399,807 (+)	NCBI		GRCr8
mRatBN7.2	2	51,649,368 - 51,667,100 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	51,649,497 - 51,667,100 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	58,768,758 - 58,786,285 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	56,827,479 - 56,845,007 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	51,761,458 - 51,778,967 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	52,427,351 - 52,445,082 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	52,431,601 - 52,445,055 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	70,791,035 - 70,809,191 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	51,737,090 - 51,754,583 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	51,665,322 - 51,682,816 (+)	NCBI
Celera	2	47,304,535 - 47,322,038 (+)	NCBI		Celera
Cytogenetic Map	2	q15	NCBI

HMGCS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	67,019,050 - 67,043,912 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	65,172,676 - 65,197,538 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	67,067,001 - 67,091,786 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	72,116,304 - 72,141,050 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	72,116,228 - 72,141,050 (+)	Ensembl	panpan1.1		panPan2

HMGCS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	66,633,706 - 66,654,005 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	66,633,572 - 66,652,196 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	66,394,617 - 66,415,022 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	67,130,232 - 67,144,820 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	67,123,795 - 67,144,508 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	66,884,796 - 66,905,197 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	67,014,391 - 67,034,791 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	67,551,264 - 67,571,669 (+)	NCBI		UU_Cfam_GSD_1.0

Hmgcs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	209,925,788 - 209,946,119 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936480	18,862,238 - 18,882,616 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936480	18,862,288 - 18,882,614 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HMGCS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	27,936,218 - 27,957,193 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	27,936,225 - 27,957,261 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	29,432,931 - 29,452,429 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HMGCS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	42,083,523 - 42,107,410 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	42,080,949 - 42,107,409 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	32,560,062 - 32,583,929 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hmgcs1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624759	11,826,876 - 11,847,111 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624759	11,826,793 - 11,847,111 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005392745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005392746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01040419	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01040420	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01090323	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000025166 ⟹ ENSCLAP00000024924

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955446	18,978,102 - 18,998,951 (+)	Ensembl

RefSeq Acc Id:

ENSCLAT00000025167 ⟹ ENSCLAP00000024925

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955446	18,978,102 - 18,998,951 (+)	Ensembl

RefSeq Acc Id:

XM_005392745 ⟹ XP_005392802

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955446	18,978,261 - 18,996,794 (+)	NCBI

Sequence:

show sequence

GAGGGAAAACCCTAGCGAGTCACCGACCCTGCTTTCCTTACGATTGGTAGAACTCGGACTAGGG
GGCGGGCGTTGGGCGGCTACTCTACCGGCTGCAATTGGCTGCTGGTGCCGCTGTCCCGCCCCCC
ACCGGCTCCCGGCGGTCCGGAGTCGGGTGGGTCTGCGGCTATAAAGCTGGCGGAGGGGAGGCGC
CGCGACCTGTCCTTTGGCGGCTCGCTCCTTTCCCTCGGTCACTTCCCGGTAACGTCTGGTGCCA
GAAGGAGGAAACAGTGACGAACCTGGAGACTGCATTTCCCTGTCCTTCCCACAGCTCTTTCACC
ATGCCTGGGTCACTTCCCGTGAATGCAGAAGCTTGTTGGCCAAAAGATGTGGGAATTGTTGCCC
TGGAGATCTATTTTCCTTCTCAATATGTTGATCAAGCAGAGTTGGAAAAATATGATGGTGTTGA
TGCTGGAAAGTATACCGTTGGCTTGGGCCAGGCAAAGATGGGCTTCTGCACAGATCGAGAGGAT
ATCAACTCTCTTTGCATGACTGTGGTTCAGAATCTGATGGAAAGAAATAGCCTTTCTTATGATT
GCATTGGACGGCTAGAGGTTGGAACAGAGACAATCATCGACAAATCAAAGTCAGTGAAGAGTAA
TTTGATGCAGCTATTTGAGGAATCTGGGAATACAGATATAGAAGGAATAGATACAACTAACGCA
TGCTATGGAGGCACAGCTGCTGTCTTCAATGCTGTTAACTGGATTGAATCTAGCTCTTGGGATG
GACGGTATGCCCTGGTAGTTGCAGGAGATATTGCTATATATGCCACAGGAAATGCCAGACCTAC
AGGTGGAGCTGGAGCTGTGGCTCTGCTAATTGGGCCAAATGCTCCTTTAATTTTTGACCGAGGG
CTTCGTGGGACACATATGCAGCATGCCTATGACTTTTACAAGCCTGATATGCTCTCTGAATATC
CTATAGTAGATGGAAAACTCTCTATACAGTGCTACCTCAGTGCATTAGACCGCTGCTATTCCGT
CTACCGTAAAAAGATCCGTGCCCAGTGGCAGAAAGAGGGAAATGATAAAGATTTCACCTTGAAT
GATTTTGGCTTCATGATCTTTCACTCACCATATTGTAAACTGGTTCAGAAATCTCTGGCTCGGA
TGATGCTGAATGATTTCCTTAATGACCAGAACAGAGATAAAAATACTATCTATAGTGGACTAGA
ATCCTTTGGGGACGTTAAATTAGAAGATACTTACTTTGATAGAGATGTGGAAAAGGCATTTATG
AAGGCCAGTTCTGAACTCTTCAATCAGAAAACAAAGGCTTCTTTGCTTGTATCAAATCAAAATG
GAAATATGTATACATCATCAGTATATGGTTCCCTGGCTTCCGTTCTAGCACAGTACTCACCTCA
GCAACTGGCAGGAAAGAAGATTGGAGTGTTTTCTTACGGTTCTGGTTTGGCTGCCACCCTGTAT
TCTCTTAGAGTCACACAGGATGCCACCCCAGGGTCTGCTCTTGATAAAATAACAGCAAGTTTAT
GTGATCTTAAATCAAGGCTTGACTCAAGAACTAGTGTGGCACCTGATGTCTTTGCTGAGAGCAT
GAAGCTCAGAGAGGACACTCATCACTTGGCCAACTATATTCCCCAGTGTTCTGTAGATTCACTT
TTTGAAGGAACATGGTATCTAGTTAGAGTGGATGAAAAGCACAGAAGAACTTATGCTCGACGTC
CCTCTCCAAACGATGACACTTTGGACGACGGAGTAGGACTTATGCATTCAAACACAGCAGCGGA
GCATATCCCAAGCCCTGCTAAGAAAGTGCCAAGACTTCCTGCAACAGCAACAGAACCCGAAGCA
GCTGTCATCAGTAATGGGGAACATTAAAATACTCTGTGAGGTGCAAAACTTCATGGTGGGGTGG
GGTGGGGTAGGGGGGATTGGAATGGGTGGAAGAATGGGACTTCAGGGGACGATTTTAAAAGATT
ACATGTTGCTTAAATTTTCTGTGACTGACAGAACCTATGAAATTATTTGTGTTCTTGGAAAAAT
CTCTGCGCAGTTGCTAATATGCTTCCTTTTGTGGTCTAGCCAATGCTAAATGTACTGGAATGAT
GTTAAGGGCTCTGTAAAATTTTATACCTCTCTGGCCATTTATATGCATGAAGTCTAGTTTTTAA
ACATGATGCAAATCATGTGCTTCTGTCAGAAGAAAGCAGAGGTACTAGTCTCCAATTTAAATTT
TTTTTAAAGATGTAAGAATTTTATACTTTGAACAAACAAGATTCATGAAAGTACATGTGGTTTT
TGAAAAATTTTTCTAGCTTAGGAAATGGGGTCTTAAAATGTGATATGAACAAACTTTGTTTGAA
AATGGTAAGACAAACATATGCTTTTTTCTAAGATTATATATCCTAAAAAAGGAGAAAAAAGTTA
AAGACAGTAACACTGGCTCTGGGCTCCAGGATACTGCTTAACGTCCAGGCCGGCTGTGACAAGT
TACTGTAATGACCTCTAAATAGAGAGATGCTAGCATCGAGCAGCTTCTGCATAGAAAACGTGGT
TCGTTTCCGAGCCATGGATATAGCTGTAGGAATTGATTGCTCTGGATCAGTGCATAGTGGATTA
TCATGCGCACGACCTTGTTATTTGGGGTATATATGAGGAAGCTTGTTGTTACAGTCTTTCTTTG
CACCTTATTTTAAAAGACACAAGAAACGTTTTTTGGCTGCCTTTGAAAAATTTAAAAAGAGGAT
GGGGCAGGGCATTATTAGGTTACTTTTGCTTCAGTGTTACAAATTTAATTTTTAGACTGACAAC
TTCAATTCATGGTGTAAGAGTTCTTTTCATTGTGCATGTGTTTTGTTTGTTTTTGGATTTTTTG
TGTATGTGTGTCTATCTGTTCAATGAAACTGAGAAAGTATGACCCAAGTTTTTATATAGTCTGA
ATAGCCAAAAAGAGAGTCCCACTTCGAAGTCTGGAAGTAGGATTTACAAAGCTTTTCTTGACTT
CCAACCTAAGAAAAAAAACAACAACAAAAAAAAAACCTGTGTCATGTGGGATAAAAAGGATTGG
TTGGAAAGTTTTATAGATGTTTTTGGTGCTGAACTATGACATGAGCCTTATAGATTGTAAAATA
CAGATAGTTGGAACTAATGTACAGAACTAAAATTTTTAAAACATTATTTGCTGTTAAATTCTGT
GAAGTTTCAGTTGTCTAAAATAACCATTCACAAATATGAAATGTAATGTTTCAGATTGCAAGGT
TGTATGTAATGTAGTGTTTGTAAGATACTCTTGTCAAATATTAACTGTAGTTTTTGACTTGTAG
TCATAATTTGTTAAAATGACTTCATTTTAACATCCACTTATGTAGATTAATGTAAGAAGAATGG
TGGGAAAATGGTGCATGTAATACTTCTGCAAGTGTTGGGAGTTCAGTATGTTTTGAAAAAAAGT
AATTTAACATTTGGGTGCCAAGAAATGGTTTTCTCAAAGTCCATTGCCGGCAATGGGCAAGCCT
GGTAATACTGGCACGGAATATTAACTATACACCTTATAATCAGTGAGGTGAATAACTTTGAAAT
AAAGTTTTAGAGAAATA

hide sequence

RefSeq Acc Id:

XM_005392746 ⟹ XP_005392803

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955446	18,978,261 - 18,996,794 (+)	NCBI

Sequence:

show sequence

GAGGGAAAACCCTAGCGAGTCACCGACCCTGCTTTCCTTACGATTGGTAGAACTCGGACTAGGG
GGCGGGCGTTGGGCGGCTACTCTACCGGCTGCAATTGGCTGCTGGTGCCGCTGTCCCGCCCCCC
ACCGGCTCCCGGCGGTCCGGAGTCGGGTGGGTCTGCGGCTATAAAGCTGGCGGAGGGGAGGCGC
CGCGACCTGTCCTTTGGCGGCTCGCTCCTTTCCCTCGGTCACTTCCCGGTAACGTCTGGCTCTT
TCACCATGCCTGGGTCACTTCCCGTGAATGCAGAAGCTTGTTGGCCAAAAGATGTGGGAATTGT
TGCCCTGGAGATCTATTTTCCTTCTCAATATGTTGATCAAGCAGAGTTGGAAAAATATGATGGT
GTTGATGCTGGAAAGTATACCGTTGGCTTGGGCCAGGCAAAGATGGGCTTCTGCACAGATCGAG
AGGATATCAACTCTCTTTGCATGACTGTGGTTCAGAATCTGATGGAAAGAAATAGCCTTTCTTA
TGATTGCATTGGACGGCTAGAGGTTGGAACAGAGACAATCATCGACAAATCAAAGTCAGTGAAG
AGTAATTTGATGCAGCTATTTGAGGAATCTGGGAATACAGATATAGAAGGAATAGATACAACTA
ACGCATGCTATGGAGGCACAGCTGCTGTCTTCAATGCTGTTAACTGGATTGAATCTAGCTCTTG
GGATGGACGGTATGCCCTGGTAGTTGCAGGAGATATTGCTATATATGCCACAGGAAATGCCAGA
CCTACAGGTGGAGCTGGAGCTGTGGCTCTGCTAATTGGGCCAAATGCTCCTTTAATTTTTGACC
GAGGGCTTCGTGGGACACATATGCAGCATGCCTATGACTTTTACAAGCCTGATATGCTCTCTGA
ATATCCTATAGTAGATGGAAAACTCTCTATACAGTGCTACCTCAGTGCATTAGACCGCTGCTAT
TCCGTCTACCGTAAAAAGATCCGTGCCCAGTGGCAGAAAGAGGGAAATGATAAAGATTTCACCT
TGAATGATTTTGGCTTCATGATCTTTCACTCACCATATTGTAAACTGGTTCAGAAATCTCTGGC
TCGGATGATGCTGAATGATTTCCTTAATGACCAGAACAGAGATAAAAATACTATCTATAGTGGA
CTAGAATCCTTTGGGGACGTTAAATTAGAAGATACTTACTTTGATAGAGATGTGGAAAAGGCAT
TTATGAAGGCCAGTTCTGAACTCTTCAATCAGAAAACAAAGGCTTCTTTGCTTGTATCAAATCA
AAATGGAAATATGTATACATCATCAGTATATGGTTCCCTGGCTTCCGTTCTAGCACAGTACTCA
CCTCAGCAACTGGCAGGAAAGAAGATTGGAGTGTTTTCTTACGGTTCTGGTTTGGCTGCCACCC
TGTATTCTCTTAGAGTCACACAGGATGCCACCCCAGGGTCTGCTCTTGATAAAATAACAGCAAG
TTTATGTGATCTTAAATCAAGGCTTGACTCAAGAACTAGTGTGGCACCTGATGTCTTTGCTGAG
AGCATGAAGCTCAGAGAGGACACTCATCACTTGGCCAACTATATTCCCCAGTGTTCTGTAGATT
CACTTTTTGAAGGAACATGGTATCTAGTTAGAGTGGATGAAAAGCACAGAAGAACTTATGCTCG
ACGTCCCTCTCCAAACGATGACACTTTGGACGACGGAGTAGGACTTATGCATTCAAACACAGCA
GCGGAGCATATCCCAAGCCCTGCTAAGAAAGTGCCAAGACTTCCTGCAACAGCAACAGAACCCG
AAGCAGCTGTCATCAGTAATGGGGAACATTAAAATACTCTGTGAGGTGCAAAACTTCATGGTGG
GGTGGGGTGGGGTAGGGGGGATTGGAATGGGTGGAAGAATGGGACTTCAGGGGACGATTTTAAA
AGATTACATGTTGCTTAAATTTTCTGTGACTGACAGAACCTATGAAATTATTTGTGTTCTTGGA
AAAATCTCTGCGCAGTTGCTAATATGCTTCCTTTTGTGGTCTAGCCAATGCTAAATGTACTGGA
ATGATGTTAAGGGCTCTGTAAAATTTTATACCTCTCTGGCCATTTATATGCATGAAGTCTAGTT
TTTAAACATGATGCAAATCATGTGCTTCTGTCAGAAGAAAGCAGAGGTACTAGTCTCCAATTTA
AATTTTTTTTAAAGATGTAAGAATTTTATACTTTGAACAAACAAGATTCATGAAAGTACATGTG
GTTTTTGAAAAATTTTTCTAGCTTAGGAAATGGGGTCTTAAAATGTGATATGAACAAACTTTGT
TTGAAAATGGTAAGACAAACATATGCTTTTTTCTAAGATTATATATCCTAAAAAAGGAGAAAAA
AGTTAAAGACAGTAACACTGGCTCTGGGCTCCAGGATACTGCTTAACGTCCAGGCCGGCTGTGA
CAAGTTACTGTAATGACCTCTAAATAGAGAGATGCTAGCATCGAGCAGCTTCTGCATAGAAAAC
GTGGTTCGTTTCCGAGCCATGGATATAGCTGTAGGAATTGATTGCTCTGGATCAGTGCATAGTG
GATTATCATGCGCACGACCTTGTTATTTGGGGTATATATGAGGAAGCTTGTTGTTACAGTCTTT
CTTTGCACCTTATTTTAAAAGACACAAGAAACGTTTTTTGGCTGCCTTTGAAAAATTTAAAAAG
AGGATGGGGCAGGGCATTATTAGGTTACTTTTGCTTCAGTGTTACAAATTTAATTTTTAGACTG
ACAACTTCAATTCATGGTGTAAGAGTTCTTTTCATTGTGCATGTGTTTTGTTTGTTTTTGGATT
TTTTGTGTATGTGTGTCTATCTGTTCAATGAAACTGAGAAAGTATGACCCAAGTTTTTATATAG
TCTGAATAGCCAAAAAGAGAGTCCCACTTCGAAGTCTGGAAGTAGGATTTACAAAGCTTTTCTT
GACTTCCAACCTAAGAAAAAAAACAACAACAAAAAAAAAACCTGTGTCATGTGGGATAAAAAGG
ATTGGTTGGAAAGTTTTATAGATGTTTTTGGTGCTGAACTATGACATGAGCCTTATAGATTGTA
AAATACAGATAGTTGGAACTAATGTACAGAACTAAAATTTTTAAAACATTATTTGCTGTTAAAT
TCTGTGAAGTTTCAGTTGTCTAAAATAACCATTCACAAATATGAAATGTAATGTTTCAGATTGC
AAGGTTGTATGTAATGTAGTGTTTGTAAGATACTCTTGTCAAATATTAACTGTAGTTTTTGACT
TGTAGTCATAATTTGTTAAAATGACTTCATTTTAACATCCACTTATGTAGATTAATGTAAGAAG
AATGGTGGGAAAATGGTGCATGTAATACTTCTGCAAGTGTTGGGAGTTCAGTATGTTTTGAAAA
AAAGTAATTTAACATTTGGGTGCCAAGAAATGGTTTTCTCAAAGTCCATTGCCGGCAATGGGCA
AGCCTGGTAATACTGGCACGGAATATTAACTATACACCTTATAATCAGTGAGGTGAATAACTTT
GAAATAAAGTTTTAGAGAAATA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005392802	(Get FASTA)	NCBI Sequence Viewer
	XP_005392803	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000024924
	ENSCLAP00000024924.1
	ENSCLAP00000024925
	ENSCLAP00000024925.1

RefSeq Acc Id:

XP_005392802 ⟸ XM_005392745

- UniProtKB:

A0A8C2W932 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPGSLPVNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTVGLGQAKMGFCTDRED
INSLCMTVVQNLMERNSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNA
CYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAIYATGNARPTGGAGAVALLIGPNAPLIFDRG
LRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGNDKDFTLN
DFGFMIFHSPYCKLVQKSLARMMLNDFLNDQNRDKNTIYSGLESFGDVKLEDTYFDRDVEKAFM
KASSELFNQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKKIGVFSYGSGLAATLY
SLRVTQDATPGSALDKITASLCDLKSRLDSRTSVAPDVFAESMKLREDTHHLANYIPQCSVDSL
FEGTWYLVRVDEKHRRTYARRPSPNDDTLDDGVGLMHSNTAAEHIPSPAKKVPRLPATATEPEA
AVISNGEH

hide sequence

RefSeq Acc Id:

XP_005392803 ⟸ XM_005392746

- UniProtKB:

A0A8C2W932 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPGSLPVNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTVGLGQAKMGFCTDRED
INSLCMTVVQNLMERNSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNA
CYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAIYATGNARPTGGAGAVALLIGPNAPLIFDRG
LRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGNDKDFTLN
DFGFMIFHSPYCKLVQKSLARMMLNDFLNDQNRDKNTIYSGLESFGDVKLEDTYFDRDVEKAFM
KASSELFNQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKKIGVFSYGSGLAATLY
SLRVTQDATPGSALDKITASLCDLKSRLDSRTSVAPDVFAESMKLREDTHHLANYIPQCSVDSL
FEGTWYLVRVDEKHRRTYARRPSPNDDTLDDGVGLMHSNTAAEHIPSPAKKVPRLPATATEPEA
AVISNGEH

hide sequence

RefSeq Acc Id:

ENSCLAP00000024925 ⟸ ENSCLAT00000025167

RefSeq Acc Id:

ENSCLAP00000024924 ⟸ ENSCLAT00000025166

Protein Domains

Hydroxymethylglutaryl-coenzyme A synthase C- Hydroxymethylglutaryl-coenzyme A synthase N-

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000017108	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000025166	ENTREZGENE
	ENSCLAT00000025166.1	UniProtKB/TrEMBL
	ENSCLAT00000025167	ENTREZGENE
	ENSCLAT00000025167.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.47.10	UniProtKB/TrEMBL
InterPro	HMG_CoA_synt_AS	UniProtKB/TrEMBL
	HMG_CoA_synt_C_dom	UniProtKB/TrEMBL
	HMG_CoA_synth_N	UniProtKB/TrEMBL
	HMG_CoA_synthase_euk	UniProtKB/TrEMBL
	Thiolase-like	UniProtKB/TrEMBL
NCBI Gene	Hmgcs1	ENTREZGENE
PANTHER	3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE	UniProtKB/TrEMBL
	HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC	UniProtKB/TrEMBL
Pfam	HMG_CoA_synt_C	UniProtKB/TrEMBL
	HMG_CoA_synt_N	UniProtKB/TrEMBL
PROSITE	HMG_COA_SYNTHASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53901	UniProtKB/TrEMBL
UniProt	A0A8C2W932	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Hmgcs1	3-hydroxy-3-methylglutaryl-CoA synthase 1		3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)