Edaradd (EDAR associated via death domain) - Rat Genome Database

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Gene: Edaradd (EDAR associated via death domain) Mus musculus
Analyze
Symbol: Edaradd
Name: EDAR associated via death domain (Ensembl:EDAR (ectodysplasin-A receptor)-associated death domain)
RGD ID: 1558198
MGI Page MGI
Description: Acts upstream of or within hair follicle development; odontogenesis of dentin-containing tooth; and trachea gland development. Is expressed in several structures, including alimentary system; metanephros; naris; skin; and ureter. Human ortholog(s) of this gene implicated in ectodermal dysplasia 11A and ectodermal dysplasia 11B. Orthologous to human EDARADD (EDAR associated via death domain).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1810032E07Rik; 5830469M23Rik; A630043P06; cr; crinkled; ectodysplasin-A receptor-associated adapter protein; EDAR (ectodysplasin-A receptor)-associated death domain; EDAR-associated death domain protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391312,486,090 - 12,535,413 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1312,487,513 - 12,535,319 (-)EnsemblGRCm39 Ensembl
GRCm381312,471,209 - 12,520,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1312,472,632 - 12,520,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv371312,569,175 - 12,612,715 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361312,531,162 - 12,574,879 (-)NCBIMGSCv36mm8
Celera1312,393,096 - 12,436,757 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.77NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (NAS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal brain morphology  (IAGP)
abnormal cerebellar layer morphology  (IAGP)
abnormal cerebellum fissure morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal coat appearance  (IEA)
abnormal coat/ hair morphology  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal enamel morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal eyelid morphology  (IEA)
abnormal hair follicle development  (IAGP)
abnormal hair growth  (IAGP)
abnormal hair texture  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal lipid level  (IAGP)
abnormal locomotor coordination  (IAGP)
abnormal maternal nurturing  (IAGP)
abnormal molar crown morphology  (IAGP)
abnormal molar cusp morphology  (IAGP)
abnormal myelination  (IAGP)
abnormal outer ear morphology  (IAGP)
abnormal respiration  (IAGP)
abnormal respiratory mucosa morphology  (IAGP)
abnormal respiratory sounds  (IEA)
abnormal skin morphology  (IAGP)
abnormal skin pigmentation  (IAGP)
abnormal tail morphology  (IEA)
abnormal tail position or orientation  (IEA)
abnormal tail ring morphology  (IEA)
abnormal tooth morphology  (IAGP)
absent guard hair  (IAGP)
absent Meibomian glands  (IAGP)
absent zigzag hairs  (IAGP)
anemia  (IAGP)
big ears  (IEA)
cornea ulcer  (IEA)
corneal opacity  (IAGP)
decreased body size  (IEA)
decreased body weight  (IAGP)
decreased eyelid cilium number  (IAGP)
decreased hair follicle number  (IAGP)
decreased litter size  (IAGP)
decreased molar number  (IAGP)
delayed hair appearance  (IAGP)
demyelination  (IAGP)
focal hair loss  (IAGP)
kinked tail  (IAGP)
narrow eye opening  (IAGP)
pallor  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
Purkinje cell degeneration  (IAGP)
reduced female fertility  (IAGP)
reduced fertility  (IAGP)
short hair  (IAGP)
small cerebellum  (IAGP)
small molars  (IAGP)
sparse hair  (IAGP)
thin dermal layer  (IAGP)
thin skin  (IAGP)
underdeveloped hair follicles  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia. Del-Pozo J, etal., Dis Model Mech. 2019 Apr 25;12(4). pii: 12/4/dmm037804. doi: 10.1242/dmm.037804.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene. Kuramoto T, etal., BMC Genet. 2011 Oct 21;12:91. doi: 10.1186/1471-2156-12-91.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:133823   PMID:320066   PMID:478295   PMID:504225   PMID:512661   PMID:544312   PMID:896803   PMID:1166079   PMID:1321288   PMID:1912584   PMID:1936982   PMID:4399067  
PMID:5361554   PMID:5361555   PMID:5446877   PMID:5500588   PMID:5548211   PMID:5806166   PMID:5893447   PMID:5959976   PMID:6062373   PMID:6774258   PMID:7983247   PMID:8854868  
PMID:10349636   PMID:10607900   PMID:11042159   PMID:11076861   PMID:11780064   PMID:11882293   PMID:12477932   PMID:12819125   PMID:14699584   PMID:15031115   PMID:15973734   PMID:16141072  
PMID:16141073   PMID:16769906   PMID:17362907   PMID:18037901   PMID:18287559   PMID:19387480   PMID:19500387   PMID:20803597   PMID:20969842   PMID:21267068   PMID:21386911   PMID:21873635  
PMID:24539712   PMID:27378689   PMID:30220568  


Genomics

Comparative Map Data
Edaradd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391312,486,090 - 12,535,413 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1312,487,513 - 12,535,319 (-)EnsemblGRCm39 Ensembl
GRCm381312,471,209 - 12,520,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1312,472,632 - 12,520,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv371312,569,175 - 12,612,715 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361312,531,162 - 12,574,879 (-)NCBIMGSCv36mm8
Celera1312,393,096 - 12,436,757 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map134.77NCBI
EDARADD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381236,348,259 - 236,484,930 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1236,348,257 - 236,502,915 (+)EnsemblGRCh38hg38GRCh38
GRCh371236,557,586 - 236,648,230 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361234,624,303 - 234,714,631 (+)NCBINCBI36Build 36hg18NCBI36
Build 341232,883,720 - 232,974,049NCBI
Celera1209,804,771 - 209,895,082 (+)NCBICelera
Cytogenetic Map1q42.3-q43NCBI
HuRef1207,012,849 - 207,103,467 (+)NCBIHuRef
CHM1_11237,829,988 - 237,920,874 (+)NCBICHM1_1
T2T-CHM13v2.01235,750,587 - 235,884,698 (+)NCBIT2T-CHM13v2.0
Edaradd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81792,850,791 - 92,894,808 (-)NCBIGRCr8
mRatBN7.21785,866,629 - 85,910,612 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1785,656,905 - 85,910,447 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01790,802,280 - 90,843,476 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1790,802,393 - 90,843,485 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01792,462,305 - 92,503,399 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41767,056,373 - 67,143,933 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1785,700,726 - 85,744,668 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
Edaradd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554923,711,549 - 3,777,528 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554923,709,819 - 3,777,506 (-)NCBIChiLan1.0ChiLan1.0
EDARADD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,702,380 - 12,787,405 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,914,211 - 12,999,256 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01211,973,108 - 212,043,142 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11217,042,359 - 217,043,804 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1216,960,418 - 217,044,046 (+)NCBIpanpan1.1panPan2
PanPan1.1 Ensembl1216,960,418 - 217,044,046 (+)Ensemblpanpan1.1panPan2
EDARADD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.143,608,545 - 3,659,357 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl43,610,079 - 3,669,789 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha43,654,946 - 3,715,144 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.043,629,190 - 3,689,391 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl43,629,181 - 3,690,451 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.143,641,762 - 3,701,937 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.043,758,964 - 3,819,177 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.043,979,463 - 4,039,647 (-)NCBIUU_Cfam_GSD_1.0
Edaradd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934440,226,404 - 40,281,250 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648416,395,935 - 16,446,146 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648416,394,753 - 16,446,102 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDARADD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1454,925,771 - 54,990,848 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11454,924,156 - 54,992,206 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21458,899,859 - 58,965,928 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDARADD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12573,537,185 - 73,625,338 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2573,538,944 - 73,626,038 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605575,628,044 - 75,715,344 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Edaradd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477514,132,710 - 14,191,423 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477514,132,455 - 14,191,604 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Edaradd
2088 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2947
Count of miRNA genes:862
Interacting mature miRNAs:1205
Transcripts:ENSMUST00000179308
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301890Adip7_madiposity 7 (mouse)Not determined13123454672Mouse
1301227Skull19_mskull morphology 19 (mouse)Not determined13123454672Mouse
1301661Tshp13_mtooth shape 13 (mouse)Not determined13123454672Mouse
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006516564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_382046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAHY01104332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF358671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY071863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY766445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT954220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000179308   ⟹   ENSMUSP00000136158
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1312,487,513 - 12,535,319 (-)Ensembl
GRCm38.p6 Ensembl1312,472,632 - 12,520,438 (-)Ensembl
RefSeq Acc Id: NM_133643   ⟹   NP_598398
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391312,486,090 - 12,535,331 (-)NCBI
GRCm381312,471,209 - 12,520,450 (-)NCBI
MGSCv371312,569,175 - 12,612,715 (-)RGD
Celera1312,387,398 - 12,436,759 (-)ENTREZGENE
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516564   ⟹   XP_006516627
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391312,487,513 - 12,535,413 (-)NCBI
GRCm381312,472,632 - 12,520,535 (-)NCBI
Sequence:
RefSeq Acc Id: XR_382046
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391312,490,396 - 12,535,408 (-)NCBI
GRCm381312,475,515 - 12,520,529 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_598398   ⟸   NM_133643
- Peptide Label: isoform 1
- UniProtKB: Q8VHX2 (UniProtKB/Swiss-Prot),   Q5D0F1 (UniProtKB/TrEMBL),   Q3UFR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006516627   ⟸   XM_006516564
- Peptide Label: isoform X1
- UniProtKB: Q8VHX2 (UniProtKB/Swiss-Prot),   Q3UFR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000136158   ⟸   ENSMUST00000179308
Protein Domains
Death

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VHX2-F1-model_v2 AlphaFold Q8VHX2 1-208 view protein structure

Promoters
RGD ID:8679586
Promoter ID:EPDNEW_M17824
Type:multiple initiation site
Name:Edaradd_1
Description:Mus musculus EDAR (ectodysplasin-A receptor)-associated deathdomain , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381312,520,383 - 12,520,443EPDNEW
RGD ID:6823831
Promoter ID:MM_KWN:13237
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:NM_133643
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361312,612,186 - 12,612,686 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1931001 AgrOrtholog
Ensembl Genes ENSMUSG00000039309
  ENSMUSG00000095105 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000179308 ENTREZGENE
  ENSMUST00000179308.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EDARADD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:171211 UniProtKB/TrEMBL
MGD MGI:1931001 ENTREZGENE
NCBI Gene 171211 ENTREZGENE
PANTHER ECTODYSPLASIN-A RECEPTOR-ASSOCIATED ADAPTER PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR28469 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Edaradd PhenoGen
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EDAD_MOUSE UniProtKB/Swiss-Prot
  Q3UFR1 ENTREZGENE, UniProtKB/TrEMBL
  Q5D0F1 ENTREZGENE, UniProtKB/TrEMBL
  Q8BY25_MOUSE UniProtKB/TrEMBL
  Q8VHX2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Edaradd  EDAR associated via death domain  Edaradd  EDAR (ectodysplasin-A receptor)-associated death domain  Symbol and/or name change 5135510 APPROVED