Timp1 (tissue inhibitor of metalloproteinase 1) - Rat Genome Database

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Gene: Timp1 (tissue inhibitor of metalloproteinase 1) Mus musculus
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Symbol: Timp1
Name: tissue inhibitor of metalloproteinase 1
RGD ID: 731433
MGI Page MGI
Description: Predicted to enable several functions, including cytokine activity; metalloendopeptidase inhibitor activity; and zinc ion binding activity. Acts upstream of or within connective tissue replacement involved in inflammatory response wound healing. Located in basement membrane. Is expressed in several structures, including alimentary system; early conceptus; hindlimb cartilage condensation; reproductive system; and skeletal system. Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cl; Clgi; collagenase inhibitor 16C8 fibroblast; EPA; erythroid-potentiating activity; metalloproteinase inhibitor 1; MGC7143; Timp; TIMP-1; tissue inhibitor of metalloproteinase-1; tissue inhibitor of metalloproteinases 1; TPA-induced protein; TPA-S1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,736,524 - 20,740,972 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,736,405 - 20,740,974 (+)EnsemblGRCm39 Ensembl
GRCm38X20,870,166 - 20,874,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,870,166 - 20,874,735 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,447,292 - 20,451,863 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,027,998 - 20,031,591 (+)NCBIMGSCv36mm8
CeleraX19,001,307 - 19,005,878 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (ISO)
alcoholic liver cirrhosis  (ISO)
Animal Disease Models  (ISO)
aortic valve insufficiency  (ISO)
atherosclerosis  (IDA)
autistic disorder  (ISO)
autoimmune disease  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
CAKUT2  (ISO)
calcinosis  (ISO)
cholangitis  (ISO)
cholestasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
congenital disorder of glycosylation type IIm  (ISO)
congestive heart failure  (ISO)
COVID-19  (ISO)
cystic fibrosis  (ISO)
degenerative disc disease  (ISO)
diabetes mellitus  (ISO)
Down syndrome  (ISO)
Emphysema  (ISO)
endometrial carcinoma  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
Female Urogenital Diseases  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
heart disease  (ISO)
heart valve disease  (ISO)
Hemorrhagic Shock  (ISO)
hyperhomocysteinemia  (IEP)
Hyperoxia  (ISO)
hypertension  (ISO)
IgA glomerulonephritis  (ISO)
immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome  (ISO)
Inflammation  (ISO)
intracranial aneurysm  (ISO)
Kawasaki disease  (ISO)
Lymphatic Metastasis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
neurodegeneration with brain iron accumulation 5  (ISO)
obesity  (ISO)
oral submucous fibrosis  (ISO)
ovarian cancer  (ISO)
pre-eclampsia  (ISO)
preretinal fibrosis  (ISO)
pulmonary fibrosis  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
renal cell carcinoma  (ISO)
Stroke  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
thoracic aortic aneurysm  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
varicose veins  (ISO)
vascular disease  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (ISO)
X-linked epilepsy with variable learning disabilities and behavior disorders  (ISO)
X-linked severe congenital neutropenia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (EXP)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (EXP)
(R)-carnitine  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allyl alcohol  (ISO)
Allylamine  (ISO)
AM-251  (ISO)
aminoguanidine  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
Ammothamnine  (ISO)
amphotericin B methyl ester  (EXP)
ampicillin  (ISO)
anandamide  (ISO)
andrographolide  (EXP)
anethole  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
Arecaidine  (ISO)
arecoline  (ISO)
Arg-Gly-Asp  (ISO)
argatroban  (EXP)
arsenic acid  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
artesunate  (ISO)
astragaloside IV  (ISO)
ATP  (EXP)
Aurothioglucose  (EXP)
Azaspiracid  (ISO)
azathioprine  (ISO)
azetidine  (EXP)
bacitracin  (ISO)
beclomethasone  (ISO)
benazepril  (ISO)
benomyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
beta-amyrin  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bezafibrate  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
bromobenzene  (ISO)
budesonide  (ISO)
busulfan  (ISO)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (EXP)
calcium dichloride  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbendazim  (ISO)
carbofuran  (ISO)
carbon nanotube  (EXP)
carfilzomib  (ISO)
carvedilol  (ISO)
carvone  (ISO)
cefaloridine  (ISO)
celastrol  (ISO)
chenodeoxycholic acid  (EXP)
chlordecone  (EXP)
chloroform  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chromium atom  (ISO)
chromium(6+)  (EXP)
chrysene  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (EXP)
cobalt atom  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP,ISO)
cucurbitacin E  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyanuric acid  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cystamine  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
diclofenac  (EXP,ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP,ISO)
diltiazem  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dizocilpine maleate  (ISO)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (ISO)
edaravone  (ISO)
elemental selenium  (ISO)
erastin  (ISO)
erythromycin estolate  (ISO)
ethanol  (EXP,ISO)
fasudil  (EXP)
fenhexamid  (ISO)
fenofibrate  (EXP)
fenoldopam  (ISO)
ferric oxide  (EXP)
Fexofenadine hydrochloride  (ISO)
flavonoids  (ISO)
fluoxetine  (ISO)
flurbiprofen  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fosinopril  (ISO)
fructose  (EXP)
fucoidan  (ISO)
furan  (ISO)
gadodiamide hydrate  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
Gly-His-Lys  (ISO)
graphene oxide  (EXP)
graphite  (ISO)
herbimycin  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
Honokiol  (EXP)
hydrogen peroxide  (ISO)
icariin  (ISO)
ilomastat  (ISO)
imiquimod  (EXP)
Indeno[1,2,3-cd]pyrene  (EXP,ISO)
indometacin  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (ISO)
isocyanuric acid  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
juglone  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (ISO)
L-methionine  (EXP,ISO)
lamivudine  (ISO)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (ISO)
lithocholic acid  (EXP)
lornoxicam  (ISO)
losartan  (ISO)
LY294002  (ISO)
Meclizine  (ISO)
megestrol  (ISO)
melamine  (ISO)
mercury dichloride  (ISO)
metaproterenol  (ISO)
methamphetamine  (ISO)
Methanandamide  (ISO)
methapyrilene  (ISO)
Methazolamide  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mifepristone  (ISO)
milrinone  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (ISO)
monodansylcadaverine  (EXP)
Muraglitazar  (ISO)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-nitrosomorpholine  (ISO)
naloxone  (ISO)
naphthalene  (EXP,ISO)
naproxen  (ISO)
naringin  (EXP)
natamycin  (EXP)
nickel atom  (ISO)
nickel sulfate  (EXP,ISO)
nicotine  (ISO)
nimodipine  (ISO)
nobiletin  (ISO)
NS-398  (ISO)
nystatin  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (EXP)
oleic acid  (ISO)
orciprenaline  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
pentane-2,3-dione  (ISO)
Pentoxifylline  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenanthrene  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (EXP)
phosphatidylcholine  (ISO)
phosphocholine  (ISO)
phosphorylcholine chloride  (ISO)
phthalaldehyde  (EXP)
pioglitazone  (ISO)
piperonyl butoxide  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP)
potassium dichromate  (EXP)
pravastatin  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (ISO)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinidine  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
raspberry ketone  (ISO)
razoxane  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rolipram  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
serpentine asbestos  (EXP)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
solasodine  (ISO)
sorafenib  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sumatriptan  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
terameprocol  (EXP)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetramethylpyrazine  (ISO)
tetraphene  (ISO)
thalidomide  (ISO)
theophylline  (ISO)
thioacetamide  (EXP,ISO)
thymoquinone  (EXP,ISO)
titanium atom  (ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP,ISO)
tomatidine  (ISO)
topotecan  (ISO)
tranexamic acid  (EXP)
trans-anethole  (ISO)
trans-rhaponticin  (ISO)
tremolite asbestos  (EXP)
triclosan  (ISO)
trimellitic anhydride  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
undecane  (ISO)
urethane  (ISO)
ursolic acid  (EXP,ISO)
valproic acid  (ISO)
valsartan  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
verapamil  (ISO)
vildagliptin  (EXP)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
XL147  (EXP)
Yessotoxin  (ISO)
zinc protoporphyrin  (ISO)
zoledronic acid  (EXP,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2007 Aug;38(8):2337-45. Epub 2007 Jun 14.
2. Serum MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in multiple sclerosis: relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment. Avolio C, etal., Mult Scler. 2005 Aug;11(4):441-6.
3. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in patients with relapsing-remitting multiple sclerosis treated with interferon beta. Boz C, etal., Clin Neurol Neurosurg. 2006 Feb;108(2):124-8.
4. Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing. Calabro A, etal., Digestion. 2004;70(2):127-38. Epub 2004 Sep 16.
5. Elevated levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 during the acute phase of Kawasaki disease. Chua PK, etal., Clin Diagn Lab Immunol. 2003 Mar;10(2):308-14.
6. Glomerular Protein Levels of Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 Are Lower in Diabetic Subjects. Cornish TC, etal., J Histochem Cytochem. 2009 Jun 8.
7. Investigation of the molecular mechanisms preceding PDE4 inhibitor-induced vasculopathy in rats: tissue inhibitor of metalloproteinase 1, a potential predictive biomarker. Dagues N, etal., Toxicol Sci. 2007 Nov;100(1):238-47. Epub 2007 Jun 14.
8. Differential spatial distribution and temporal regulation of tissue inhibitor of metalloproteinase mRNA expression during rat central nervous system development. Fager N and Jaworski DM, Mech Dev. 2000 Nov;98(1-2):105-9.
9. [Metalloproteinases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 levels in children and adolescents with type 1 diabetes.] Florys B, etal., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2006;12(3):184-9.
10. Elevated matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in obese children and adolescents. Glowinska-Olszewska B and Urban M, Metabolism. 2007 Jun;56(6):799-805.
11. Tissue inhibitor of metalloproteinase 1 is an independent predictor of prognosis in patients with nonsmall cell lung carcinoma who undergo resection with curative intent. Gouyer V, etal., Cancer. 2005 Apr 15;103(8):1676-84.
12. [Expression of matrix metalloproteinase-2, 9 and it's tissue inhibitor-1, 2 in endometrial carcinoma] Guo W, etal., Zhonghua Fu Chan Ke Za Zhi. 2002 Oct;37(10):604-7.
13. Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart. Heymans S, etal., Circulation. 2005 Aug 23;112(8):1136-44. Epub 2005 Aug 15.
14. Hyperoxia decreases matrix metalloproteinase-9 and increases tissue inhibitor of matrix metalloproteinase-1 protein in the newborn rat lung: association with arrested alveolarization. Hosford GE, etal., Pediatr Res. 2004 Jul;56(1):26-34. Epub 2004 May 5.
15. Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage. Hultstrom M, etal., Nephrol Dial Transplant. 2008 Mar;23(3):896-903. Epub 2007 Oct 31.
16. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
17. Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis. Iredale JP, etal., Hepatology. 1996 Jul;24(1):176-84.
18. Nerve growth factor metabolic dysfunction in Down's syndrome brains. Iulita MF, etal., Brain. 2014 Mar;137(Pt 3):860-72. doi: 10.1093/brain/awt372. Epub 2014 Feb 11.
19. Differential regulation of tissue inhibitor of metalloproteinase mRNA expression in response to intracranial injury. Jaworski DM Glia. 2000 Apr;30(2):199-208.
20. TIMP-1 transgenic mice recover from diabetes induced by multiple low-dose streptozotocin. Jiang H, etal., Diabetes. 2007 Jan;56(1):49-56.
21. Mechanism of Yiqi Huayu Bushen Recipe in treating cervical syndrome with kidney deficiency in rats Jiang JC, etal., Zhong Xi Yi Jie He Xue Bao. 2008 Dec;6(12):1280-5. doi: 10.3736/jcim200812114.
22. Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma. Kallakury BV, etal., Clin Cancer Res. 2001 Oct;7(10):3113-9.
23. Increased levels of serum tissue inhibitor of metalloproteinase-1 but not metalloproteinase-3 in atopic dermatitis. Katoh N, etal., Clin Exp Immunol. 2002 Feb;127(2):283-8.
24. Tissue inhibitor of metalloproteinases-1, -2, and -3 polymorphisms in a white population with intracranial aneurysms. Krex D, etal., Stroke. 2003 Dec;34(12):2817-21. Epub 2003 Nov 6.
25. Alterations in peripheral blood levels of TIMP-1, MMP-2, and MMP-9 in patients with type-2 diabetes. Lee SW, etal., Diabetes Res Clin Pract. 2005 Aug;69(2):175-9.
26. MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition. Li H, etal., Cardiovasc Res. 2000 May;46(2):298-306.
27. Elevated plasma tissue inhibitor of metalloproteinase-1 level predicts decreased response and survival in metastatic breast cancer. Lipton A, etal., Cancer. 2007 May 15;109(10):1933-9.
28. Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases. Lorenzl S, etal., J Neurol Sci. 2003 Mar 15;207(1-2):71-6.
29. Matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) and their tissue inhibitors (TIMP-1 and TIMP-2) in differential diagnosis between low malignant potential (LMP) and malignant ovarian tumours. Maatta M, etal., Anticancer Res. 2007 Jul-Aug;27(4C):2753-8.
30. Inhibition of matrix metalloproteinase on hepatic transforming growth factor beta1 and caspase-3 activation in hemorrhage. Maitra SR, etal., Acad Emerg Med. 2005 Sep;12(9):797-803. doi: 10.1197/j.aem.2005.04.017.
31. Increased levels of tissue inhibitor of metalloproteinase-1 in human hepatocellular carcinoma. Matsumoto E, etal., Liver Int. 2004 Aug;24(4):379-83.
32. MMP-9, TIMP-1 and inflammatory cells in sputum from COPD patients during exacerbation. Mercer PF, etal., Respir Res. 2005 Dec 22;6:151.
33. MGDs mouse GO annotations MGD data from the GO Consortium
34. MGD IEA MGD IEA
35. Epigenetic regulation of aortic remodeling in hyperhomocysteinemia. Narayanan N, etal., FASEB J. 2014 Aug;28(8):3411-22. doi: 10.1096/fj.14-250183. Epub 2014 Apr 16.
36. Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. Ogata T, etal., J Vasc Surg. 2005 Jun;41(6):1036-42.
37. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
38. Identification of neutrophil activation markers as novel surrogate markers of CF lung disease. Rath T, etal., PLoS One. 2014 Dec 29;9(12):e115847. doi: 10.1371/journal.pone.0115847. eCollection 2014.
39. MMP9 overexpression is associated with good surgical outcome in children with UPJO: Preliminary results. Reis ST, etal., BMC Urol. 2016 Jul 23;16(1):44. doi: 10.1186/s12894-016-0162-6.
40. Mouse MP Annotation Import Pipeline RGD automated import pipeline
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Tissue inhibitor of matrix metalloproteinase-1 is prognostic in head and neck squamous cell carcinoma: comparison of the circulating and tissue immunoreactive protein. Ruokolainen H, etal., Clin Cancer Res. 2005 May 1;11(9):3257-64.
43. Matrix metalloproteinases and their natural inhibitors in fibrovascular membranes of proliferative diabetic retinopathy. Salzmann J, etal., Br J Ophthalmol. 2000 Oct;84(10):1091-6.
44. Tumor tissue levels of tissue inhibitor of metalloproteinase-1 as a prognostic marker in primary breast cancer. Schrohl AS, etal., Clin Cancer Res. 2004 Apr 1;10(7):2289-98.
45. Primary tumor levels of tissue inhibitor of metalloproteinases-1 are predictive of resistance to chemotherapy in patients with metastatic breast cancer. Schrohl AS, etal., Clin Cancer Res. 2006 Dec 1;12(23):7054-8. Epub 2006 Nov 17.
46. Concentrations of TIMP1 mRNA splice variants and TIMP-1 protein are differentially associated with prognosis in primary breast cancer. Sieuwerts AM, etal., Clin Chem. 2007 Jul;53(7):1280-8. Epub 2007 May 3.
47. Combined determination of plasma MMP2, MMP9, and TIMP1 improves the non-invasive detection of transitional cell carcinoma of the bladder. Staack A, etal., BMC Urol. 2006 Aug 10;6:19.
48. Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia. Suryadevara R, etal., Glia. 2003 Oct;44(1):47-56.
49. Broncho-alveolar lavage matrix metalloproteases as a sensitive measure of bronchiolitis obliterans. Taghavi S, etal., Am J Transplant. 2005 Jun;5(6):1548-52.
50. Tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9 levels in patients with hypertension Relationship to tissue Doppler indices of diastolic relaxation. Tayebjee MH, etal., Am J Hypertens. 2004 Sep;17(9):770-4.
51. Circulating matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases-1 and -2 levels in gestational hypertension. Tayebjee MH, etal., Am J Hypertens. 2005 Mar;18(3):325-9.
52. Cerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction. Thibert KA, etal., PLoS One. 2012;7(11):e50430. doi: 10.1371/journal.pone.0050430. Epub 2012 Nov 21.
53. Increased mRNA expression of tissue inhibitors of metalloproteinase-1 and -2 in Duchenne muscular dystrophy. von Moers A, etal., Acta Neuropathol (Berl). 2005 Mar;109(3):285-93. Epub 2004 Dec 23.
54. Effect of Liuweibuqi capsule, a Chinese patent medicine, on the JAK1/STAT3 pathway and MMP9/TIMP1 in a chronic obstructive pulmonary disease rat model. Wang C, etal., J Tradit Chin Med. 2015 Feb;35(1):54-62.
55. Subtractive cloning identifies tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) increased gene expression following focal stroke. Wang X, etal., Stroke. 1998 Feb;29(2):516-20.
56. Plasma matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 as biomarkers of ulcerative colitis activity. Wiercinska-Drapalo A, etal., World J Gastroenterol. 2003 Dec;9(12):2843-5.
57. Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease. Wollmer MA, etal., Psychiatr Genet. 2002 Sep;12(3):155-60.
58. Prognostic significance of MMP-9 and TIMP-1 serum and tissue expression in breast cancer. Wu ZS, etal., Int J Cancer. 2008 May 1;122(9):2050-6.
59. Silencing of long non-coding RNA H19 downregulates CTCF to protect against atherosclerosis by upregulating PKD1 expression in ApoE knockout mice. Yang Y, etal., Aging (Albany NY). 2019 Nov 22;11(22):10016-10030. doi: 10.18632/aging.102388. Epub 2019 Nov 22.
60. [Expression of trophoblast invasion related genes mRNA and protein in human placenta in preeclampsia]. Zhang H, etal., Zhonghua Fu Chan Ke Za Zhi. 2006 Aug;41(8):509-13.
61. Zhonghua xin xue guan bing za zhi ZHANG N, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2008 Dec;36(12):1115-9.
62. Distribution and expression of tissue inhibitors of metalloproteinase in dorsal root entry zone and dorsal column after dorsal root injury. Zhang X, etal., J Neurosci Res. 2006 Aug 1;84(2):278-90.
63. [Modulative effect of zhenqing recipe on expressions of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in experimental type 2 diabetic rats] Zheng LY, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jun;26 Suppl:72-6.
64. Inhibitory effects of alkaline extract of Citrus reticulata on pulmonary fibrosis. Zhou XM, etal., J Ethnopharmacol. 2013 Mar 7;146(1):372-8. doi: 10.1016/j.jep.2013.01.006. Epub 2013 Jan 11.
65. Erythromycin ameliorates cigarette-smoke-induced emphysema and inflammation in rats. Zhou Y, etal., Transl Res. 2012 Jun;159(6):464-72. doi: 10.1016/j.trsl.2011.09.007. Epub 2011 Oct 24.
Additional References at PubMed
PMID:1322839   PMID:1380797   PMID:1420363   PMID:1480036   PMID:1480037   PMID:1572636   PMID:1617221   PMID:1634117   PMID:1675194   PMID:1849903   PMID:1916808   PMID:1964443  
PMID:2004781   PMID:2011396   PMID:2110546   PMID:2120112   PMID:2180930   PMID:2573045   PMID:2693036   PMID:2744464   PMID:2850484   PMID:2906327   PMID:3024122   PMID:3034603  
PMID:3588297   PMID:3670294   PMID:3837843   PMID:3903517   PMID:6179042   PMID:7568108   PMID:7626795   PMID:7693055   PMID:7743917   PMID:7777057   PMID:7849405   PMID:7894006  
PMID:8110467   PMID:8118794   PMID:8243459   PMID:8352925   PMID:8674412   PMID:8760297   PMID:8835523   PMID:8957071   PMID:9013889   PMID:9022062   PMID:9108368   PMID:9160717  
PMID:9285822   PMID:9291579   PMID:9687309   PMID:10090151   PMID:10225966   PMID:10232461   PMID:10395785   PMID:10415752   PMID:10430768   PMID:10441734   PMID:10459021   PMID:10590246  
PMID:10621841   PMID:10652195   PMID:10731089   PMID:10916085   PMID:10952938   PMID:10985432   PMID:11052264   PMID:11193216   PMID:11274235   PMID:11359935   PMID:11675412   PMID:11717141  
PMID:11732988   PMID:11739522   PMID:11865039   PMID:11869290   PMID:11988080   PMID:11988491   PMID:12097550   PMID:12297832   PMID:12388239   PMID:12466851   PMID:12477932   PMID:12488323  
PMID:12525489   PMID:12538437   PMID:12574803   PMID:12655789   PMID:12704667   PMID:12815621   PMID:12904583   PMID:12950084   PMID:12975354   PMID:14568914   PMID:14610273   PMID:14630637  
PMID:15063736   PMID:15084483   PMID:15364874   PMID:15489334   PMID:15502710   PMID:15536133   PMID:15598866   PMID:15618213   PMID:15631996   PMID:15680392   PMID:15726641   PMID:15734845  
PMID:15947421   PMID:16107690   PMID:16113801   PMID:16141072   PMID:16141211   PMID:16288749   PMID:16307599   PMID:16316466   PMID:16368545   PMID:16388023   PMID:16418837   PMID:16469749  
PMID:16584649   PMID:16691494   PMID:16860884   PMID:16873063   PMID:16949899   PMID:17030988   PMID:17148673   PMID:17235437   PMID:17545477   PMID:17602244   PMID:17652357   PMID:17967808  
PMID:17982264   PMID:18055551   PMID:18178676   PMID:18298469   PMID:18299419   PMID:18385523   PMID:18537133   PMID:18559979   PMID:18560439   PMID:18596727   PMID:18639653   PMID:18641199  
PMID:18681831   PMID:18799693   PMID:18817873   PMID:18955015   PMID:19036876   PMID:19092727   PMID:19339693   PMID:19411759   PMID:19469687   PMID:19608737   PMID:19624892   PMID:19780057  
PMID:20011518   PMID:20230750   PMID:20558576   PMID:20564215   PMID:20595636   PMID:20598569   PMID:20661871   PMID:20665818   PMID:20683677   PMID:21047948   PMID:21053058   PMID:21267068  
PMID:21300026   PMID:21350939   PMID:21421844   PMID:21437772   PMID:21508247   PMID:21521782   PMID:21631912   PMID:21750040   PMID:21764281   PMID:21873635   PMID:22014525   PMID:22289852  
PMID:22327365   PMID:22438979   PMID:23016931   PMID:23017058   PMID:23071737   PMID:23080298   PMID:23089194   PMID:23100531   PMID:23113307   PMID:23298833   PMID:23443810   PMID:23524300  
PMID:23555662   PMID:23660069   PMID:23755187   PMID:23755201   PMID:23776165   PMID:23825222   PMID:23946498   PMID:24006456   PMID:24108368   PMID:24156369   PMID:24174628   PMID:24194600  
PMID:24279124   PMID:24373743   PMID:24471921   PMID:24526442   PMID:25075518   PMID:25131634   PMID:25131778   PMID:25150980   PMID:25183545   PMID:25193593   PMID:25204377   PMID:25211233  
PMID:25572963   PMID:25576870   PMID:25636537   PMID:25706237   PMID:25805621   PMID:25807548   PMID:25920569   PMID:25934838   PMID:25964075   PMID:26001794   PMID:26168159   PMID:26358260  
PMID:26484505   PMID:26645981   PMID:26898191   PMID:27134175   PMID:27189410   PMID:27194531   PMID:27430487   PMID:27506299   PMID:27621061   PMID:28064417   PMID:28386095   PMID:28582477  
PMID:28710453   PMID:28765154   PMID:28992358   PMID:29291636   PMID:29322806   PMID:29567669   PMID:29742163   PMID:29845213   PMID:29870740   PMID:30167842   PMID:30572657   PMID:30670377  
PMID:30822518   PMID:31189971   PMID:31371388   PMID:31616247   PMID:32035727   PMID:32071226   PMID:32113948   PMID:32546759   PMID:32702237   PMID:33028100   PMID:33159885   PMID:33186519  
PMID:33357457   PMID:33763067   PMID:33941611   PMID:34533565   PMID:34767447   PMID:34818584   PMID:35513123   PMID:36066006   PMID:36414671   PMID:36457117   PMID:36675165   PMID:36878326  
PMID:36920550   PMID:37225978   PMID:37269543   PMID:37312667   PMID:37325923   PMID:37851372  


Genomics

Comparative Map Data
Timp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,736,524 - 20,740,972 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,736,405 - 20,740,974 (+)EnsemblGRCm39 Ensembl
GRCm38X20,870,166 - 20,874,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,870,166 - 20,874,735 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,447,292 - 20,451,863 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,027,998 - 20,031,591 (+)NCBIMGSCv36mm8
CeleraX19,001,307 - 19,005,878 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.38NCBI
TIMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,582,436 - 47,586,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,582,408 - 47,586,789 (+)EnsemblGRCh38hg38GRCh38
GRCh37X47,441,835 - 47,446,188 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,326,634 - 47,331,134 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X47,198,084 - 47,202,441NCBI
CeleraX51,636,947 - 51,641,447 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX45,154,211 - 45,158,632 (+)NCBIHuRef
CHM1_1X47,472,792 - 47,477,292 (+)NCBICHM1_1
T2T-CHM13v2.0X46,992,326 - 46,996,679 (+)NCBIT2T-CHM13v2.0
Timp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,766,509 - 3,772,578 (-)NCBIGRCr8
mRatBN7.2X1,212,969 - 1,217,714 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,212,972 - 1,217,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,241,133 - 1,245,729 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,716,824 - 4,721,420 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,037,983 - 1,042,580 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,364,771 - 1,369,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,364,786 - 1,369,384 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,542,496 - 12,547,094 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,548,051 - 12,552,650 (-)NCBI
CeleraX1,780,586 - 1,785,184 (-)NCBICelera
Cytogenetic MapXq11NCBI
Timp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516505,789 - 512,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955516507,113 - 511,360 (-)NCBIChiLan1.0ChiLan1.0
TIMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X49,208,573 - 49,213,215 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X49,212,076 - 49,216,587 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,018,190 - 40,022,636 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,914,906 - 47,919,419 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,914,906 - 47,919,419 (+)Ensemblpanpan1.1panPan2
TIMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,201,623 - 41,205,314 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,201,638 - 41,205,310 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,576,764 - 15,580,333 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,335,929 - 41,339,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,335,826 - 41,339,498 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,323,532 - 41,327,103 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,311,800 - 41,315,371 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,404,449 - 41,408,018 (+)NCBIUU_Cfam_GSD_1.0
Timp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,505,193 - 33,509,420 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650213,345,832 - 13,350,248 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650213,345,936 - 13,350,170 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,102,172 - 42,106,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,103,251 - 42,106,289 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,372,604 - 47,375,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXpNCBI
LOC103231892
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,759,412 - 44,763,243 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,760,531 - 44,765,571 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366656624,012 - 27,843 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624978121,803 - 124,912 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624978120,723 - 125,006 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Timp1
156 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:221
Count of miRNA genes:105
Interacting mature miRNAs:108
Transcripts:ENSMUST00000009530, ENSMUST00000115342
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302195Pbwg10_mpostnatal body weight growth 10 (mouse)Not determinedX126202173Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
1301551Spha1_msperm head anomaly 1 (mouse)Not determinedX1026622539921652Mouse
13208553Wght11_mweight 11 (mouse)X1186623959045360Mouse
13208557Lgth13_mbody length 13 (mouse)X1186623959045360Mouse
1558721Bw1_mbody weight QTL 1 (mouse)Not determinedX2060678347179225Mouse

Markers in Region
PMC115071P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X20,873,052 - 20,873,455UniSTSGRCm38
MGSCv37X20,450,178 - 20,450,581UniSTSGRCm37
CeleraX19,004,193 - 19,004,596UniSTS
Cytogenetic MapXA1-A4UniSTS
Cytogenetic MapXA1.3UniSTS
Timp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X20,869,358 - 20,869,897UniSTSGRCm38
MGSCv37X20,446,484 - 20,447,023UniSTSGRCm37
CeleraX19,000,499 - 19,001,038UniSTS
Cytogenetic MapXA1-A4UniSTS
Cytogenetic MapXA1.3UniSTS
Timp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X20,873,082 - 20,874,604UniSTSGRCm38
MGSCv37X20,450,208 - 20,451,730UniSTSGRCm37
CeleraX19,004,223 - 19,005,745UniSTS
Cytogenetic MapXA1-A4UniSTS
Cytogenetic MapXA1.3UniSTS
cM MapX6.2UniSTS
Timp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA1.3UniSTS
Timp1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA1.3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001044384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001294280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001426018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001426019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001426020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA184230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH004952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL671885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY622853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU756519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ055052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ063120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X69413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000009530   ⟹   ENSMUSP00000009530
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX20,736,460 - 20,740,974 (+)Ensembl
GRCm38.p6 EnsemblX20,870,221 - 20,874,735 (+)Ensembl
RefSeq Acc Id: ENSMUST00000115342   ⟹   ENSMUSP00000110999
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX20,736,405 - 20,740,972 (+)Ensembl
GRCm38.p6 EnsemblX20,870,166 - 20,874,733 (+)Ensembl
RefSeq Acc Id: NM_001044384   ⟹   NP_001037849
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X20,736,524 - 20,740,972 (+)NCBI
GRCm38X20,870,166 - 20,874,737 (+)ENTREZGENE
MGSCv37X20,447,292 - 20,451,863 (+)RGD
CeleraX19,001,307 - 19,005,878 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001294280   ⟹   NP_001281209
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X20,736,524 - 20,740,972 (+)NCBI
GRCm38X20,870,166 - 20,874,737 (+)NCBI
CeleraX19,001,307 - 19,005,878 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001426018   ⟹   NP_001412947
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X20,736,524 - 20,740,972 (+)NCBI
RefSeq Acc Id: NM_001426019   ⟹   NP_001412948
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X20,736,524 - 20,740,137 (+)NCBI
RefSeq Acc Id: NM_001426020   ⟹   NP_001412949
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X20,736,524 - 20,740,137 (+)NCBI
RefSeq Acc Id: NM_011593   ⟹   NP_035723
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X20,736,524 - 20,740,972 (+)NCBI
GRCm38X20,870,166 - 20,874,737 (+)ENTREZGENE
MGSCv37X20,447,292 - 20,451,863 (+)RGD
CeleraX19,001,307 - 19,005,878 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001037849   ⟸   NM_001044384
- Peptide Label: isoform a precursor
- UniProtKB: P20064 (UniProtKB/Swiss-Prot),   Q61720 (UniProtKB/Swiss-Prot),   P12032 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_035723   ⟸   NM_011593
- Peptide Label: isoform a precursor
- UniProtKB: P20064 (UniProtKB/Swiss-Prot),   Q61720 (UniProtKB/Swiss-Prot),   P12032 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001281209   ⟸   NM_001294280
- Peptide Label: isoform b
- Sequence:
RefSeq Acc Id: ENSMUSP00000009530   ⟸   ENSMUST00000009530
RefSeq Acc Id: ENSMUSP00000110999   ⟸   ENSMUST00000115342
RefSeq Acc Id: NP_001412947   ⟸   NM_001426018
- Peptide Label: isoform b
RefSeq Acc Id: NP_001412949   ⟸   NM_001426020
- Peptide Label: isoform c precursor
RefSeq Acc Id: NP_001412948   ⟸   NM_001426019
- Peptide Label: isoform c precursor
Protein Domains
NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12032-F1-model_v2 AlphaFold P12032 1-205 view protein structure

Promoters
RGD ID:6846453
Promoter ID:MM_KWN:59756
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   Brain,   ES_Cell,   MEF_B4,   MEF_B6
Transcripts:NM_001044384,   NM_011593
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X20,446,516 - 20,447,667 (+)MPROMDB
RGD ID:13680200
Promoter ID:EPDNEW_M24250
Type:initiation region
Name:Timp1_1
Description:Mus musculus tissue inhibitor of metalloproteinase 1 , transcriptvariant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X20,870,290 - 20,870,350EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98752 AgrOrtholog
Ensembl Genes ENSMUSG00000001131 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000009530 ENTREZGENE
  ENSMUST00000009530.5 UniProtKB/Swiss-Prot
  ENSMUST00000115342 ENTREZGENE
  ENSMUST00000115342.10 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot
  3.90.370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Netrin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_CS UniProtKB/Swiss-Prot
KEGG Report mmu:21857 UniProtKB/Swiss-Prot
MGD MGI:98752 ENTREZGENE
NCBI Gene 21857 ENTREZGENE
PANTHER PTHR11844 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11844:SF20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Timp1 PhenoGen
PROSITE NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/Swiss-Prot
SMART NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P12032 ENTREZGENE
  P20064 ENTREZGENE
  Q61720 ENTREZGENE
  Q6GXA9_MOUSE UniProtKB/TrEMBL
  TIMP1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P20064 UniProtKB/Swiss-Prot
  Q61720 UniProtKB/Swiss-Prot