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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731433
Species: Mus musculus
RGD Object: Gene
Symbol: Timp1
Name: tissue inhibitor of metalloproteinase 1
Acc ID: CHEBI:9948
Term: verapamil
Definition: A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
Chemical ID: MESH:D014700
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp1affects expressionISOTIMP1 (Homo sapiens)6480464CTDVerapamil affects the expression of TIMP1 proteinPMID:12388792
Timp1multiple interactionsISOTimp1 (Rattus norvegicus)6480464CTDVerapamil inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein]PMID:27095094
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