RGD Reference Report - Elevated levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 during the acute phase of Kawasaki disease. - Rat Genome Database

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Elevated levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 during the acute phase of Kawasaki disease.

Authors: Chua, PK  Melish, ME  Yu, Q  Yanagihara, R  Yamamoto, KS  Nerurkar, VR 
Citation: Chua PK, etal., Clin Diagn Lab Immunol. 2003 Mar;10(2):308-14.
RGD ID: 1580170
Pubmed: PMID:12626459   (View Abstract at PubMed)
PMCID: PMC150536   (View Article at PubMed Central)

Kawasaki disease (KD) is an acute, self-limiting, multisystem vasculitis of unknown etiology affecting infants and young children. Unless treated promptly with high-dose intravenous gamma globulin and aspirin, patients frequently develop coronary aneurysms. Previously, matrix metalloproteinase 9 (MMP-9), which is secreted complexed to tissue inhibitor of metalloproteinase 1 (TIMP-1), has been implicated in abdominal aortic aneurysm formation. Since the clinical and pathological features of KD include inflammation and weakening of blood vessels, we analyzed acute- and convalescent-phase paired plasma or serum samples from 31 KD patients, 7 patients who did not completely meet the criteria for KD, and 26 non-KD controls (9 febrile and 17 afebrile patients) for pro-MMP-9 (92 kDa) enzyme activity by gelatin zymography and for active MMP-9 (83 kDa), pro-MMP-9, and TIMP-1 protein levels by enzyme-linked immunosorbent assay. Statistical analysis was performed by using Student t tests, linear regression, and the Wilcoxon rank-sum test. Markedly elevated pro-MMP-9 enzymatic activity, pro-MMP-9 protein levels, and TIMP-1 protein levels were found during the acute phase of illness in patients with clinically established KD and in patients who were suspected of having KD but did not meet all of the criteria. There was no significant difference in active MMP-9 levels. Furthermore, pro-MMP-9 and TIMP-1 protein levels were significantly elevated among KD patients, compared to those of febrile and afebrile non-KD controls. The significantly elevated pro-MMP-9 enzyme and protein levels during the acute phase of KD may reflect vascular remodeling or an inflammatory response to a microbial agent, suggesting a pathophysiological role for MMP-9 in coronary aneurysm formation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Kawasaki disease  IEP 1580170; 1580170protein:increased expression:bloodRGD 
Kawasaki disease  ISOMMP9 (Homo sapiens)1580170; 1580170protein:increased expression:bloodRGD 
Kawasaki disease  ISOTIMP1 (Homo sapiens)1580170; 1580170protein:increased expression:bloodRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp9  (matrix metallopeptidase 9)
Timp1  (TIMP metallopeptidase inhibitor 1)

Genes (Mus musculus)
Mmp9  (matrix metallopeptidase 9)
Timp1  (tissue inhibitor of metalloproteinase 1)

Genes (Homo sapiens)
MMP9  (matrix metallopeptidase 9)
TIMP1  (TIMP metallopeptidase inhibitor 1)


Additional Information