INTERLEUKIN-6 SIGNALING PATHWAY (PW:0000516)

View Ontology Report

Description

Discovered in 1986 as a B-cell differentiation factor, interleukin 6 (Il6) is now known to be the archetypal member of a family of cytokines involved in a broad range of biological processes. Interleukin 6 signaling pathway plays important regulatory roles in immune responses, inflammation, embryonic development, the hematopoietic and nervous systems. Characteristic of Il6 family mediated signaling is the shared use of a co-receptor transducer molecule - Il6st, known as gp130. Il6 is expressed i

Pathway Diagram:

Elsevier Inc. Tocilizumab Adam17 Adam10 IL6st ---> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos1 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Grb2 Y759 IL6st --+> Jak-Stat signaling pathway IL6st --+> Jak(s) Jak(s) --+> Stat(s) Tocilizumab ---| sIl6r Stat(s) Jak(s) IL6st sIl6st ---| IL6st Tocilizumab ---| Il6r Il6 Sos2 Ptpn11 Il6r Jak-Stat signaling pathway the extracellular signal-regulated Raf/Mek/Erk signaling pathway sIl6r ---- Tocilizumab Il6r ---- Tocilizumab IL6st ---- sIl6r Il6 ---- sIl6r Sos1 IL6st ---- Ptpn11 Grb2 ---- Ptpn11 IL6st ---- Stat(s) sIl6st Adam17 ---> sIl6r sIl6r Adam10 ---> sIl6r sIl6r ---- sIl6st Jak(s) ---> IL6st IL6st ---- Jak(s) Il6r ---- IL6st Il6 ---- Il6r Il6 ---- IL6st Jak(s) ---> Ptpn11
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns
interleukin-6 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:6484113
G Adam10 ADAM metallopeptidase domain 10 JBrowse link 8 77,107,355 77,237,483 RGD:5686846
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:5686834
RGD:5686846
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6484113
G Cebpd CCAAT/enhancer binding protein delta JBrowse link 11 89,008,008 89,009,146 RGD:6484113
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:6484113
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:6484113
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6484113
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:6484113
G Gab1 GRB2-associated binding protein 1 JBrowse link 19 30,794,290 30,903,819 RGD:6484113
G Gab2 GRB2-associated binding protein 2 JBrowse link 1 162,082,876 162,283,379 RGD:6484113
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:5686834
RGD:6484113
G Hck HCK proto-oncogene, Src family tyrosine kinase JBrowse link 3 148,579,917 148,623,026 RGD:6484113
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link 7 27,226,570 27,240,533 RGD:6484113
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1580493
RGD:5686834
RGD:5686839
RGD:6484113
RGD:11062097
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:5686834
RGD:5686839
RGD:6484113
G Il6st interleukin 6 signal transducer JBrowse link 2 44,279,199 44,319,427 RGD:5686834
RGD:5686839
RGD:5686900
RGD:6484113
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:6484113
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:5686839
RGD:6484113
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:5686839
RGD:6484113
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6484113
G Junb JunB proto-oncogene, AP-1 transcription factor subunit JBrowse link 19 26,092,972 26,094,756 RGD:6484113
G Lbp lipopolysaccharide binding protein JBrowse link 3 154,786,232 154,812,910 RGD:6484113
G Lmo4 LIM domain only 4 JBrowse link 2 250,218,635 250,235,435 RGD:6484113
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6484113
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:6484113
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6484113
G Mcl1 MCL1, BCL2 family apoptosis regulator JBrowse link 2 197,786,212 197,788,992 RGD:6484113
G Mitf melanogenesis associated transcription factor JBrowse link 4 130,172,484 130,425,496 RGD:6484113
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6484113
G Pias1 protein inhibitor of activated STAT, 1 JBrowse link 8 67,771,720 67,869,015 RGD:6484113
G Pias3 protein inhibitor of activated STAT, 3 JBrowse link 2 198,821,377 198,831,533 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:6484113
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:5686834
RGD:6484113
G Rac1 ras-related C3 botulinum toxin substrate 1 JBrowse link 12 13,090,316 13,111,841 RGD:6484113
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6484113
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:5686834
RGD:6484113
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:5686834
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:5686834
RGD:5686839
RGD:6484113
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:5686834
RGD:5686839
RGD:6484113
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:6484113
G Tnfsf11 TNF superfamily member 11 JBrowse link 15 60,482,527 60,512,704 RGD:6484113
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:5686839
RGD:6484113
G Vav1 vav guanine nucleotide exchange factor 1 JBrowse link 9 9,617,551 9,675,167 RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ProteinsIl6sta soluble form of Il6st that acts as an inhibitor of trans-signaling
ProteinsIl6ra soluble form of the Il6 receptor involved in trans-signaling
PathwayJak-Stat signaling pathwayan important intracellular cascade initiated in response to cytokine signaling
Pathwaythe extracellular signal-regulated Raf/Mek/Erk signaling pathwayan important MAPK cascade downstream of many activated cell surface receptors
Small MoleculeTocilizumabinhibitor of Il6 receptors
Functional ClassStat(s)members of Stat transcription factors associated with Ilst
Functional ClassJak(s)members of the Janus kinase associated with Il6st

Pathway Gene Annotations

Disease Annotations Associated with Genes in the interleukin-6 signaling pathway
Disease TermsGene Symbols
2-HydroxyglutaricaciduriaSos2
Abortion, SpontaneousIl6 , Jak2
Absent Radii and ThrombocytopeniaPias3
Acute Coronary SyndromeCrp , Il6
Acute Kidney InjuryA2m , Crp , Il6 , Myc
Acute Lung InjuryIl6
Acute UveitisCrp
Acute-Phase ReactionIl6 , Il6r
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
AdenocarcinomaMyc , Pik3ca , Ptpn11 , Stat3
Adenocarcinoma of EsophagusPik3ca
Adenocarcinoma of LungAkt1 , Junb , Myc , Pik3ca , Ptpn11 , Sos1 , Vav1
ADENOCARCINOMA OF STOMACHAkt1 , Pik3ca , Ptpn11
Adenocarcinoma, ProstaticAkt1 , Pik3ca
Adenoma, Liver CellA2m
Adenomatous Polyposis ColiAkt1
Adenovirus Infections, HumanCrp
Adrenocortical CarcinomaPik3ca
AdrenoleukodystrophyTimp1
AfibrinogenemiaFgg
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Aggressive PeriodontitisCrp
Aging, PrematureFoxo1
Albinism Ocular Late Onset Sensorineural DeafnessMitf
Albinism, OculocutaneousMitf
AlbuminuriaCrp , Il6
Alpha-2-Macroglobulin DeficiencyA2m
Alveolar Bone LossTnfsf11
Alzheimer DiseaseA2m , Akt1 , Cebpb , Crp , Il6 , Il6r , Il6st , Jak2 , Mapk14 , Pik3r1 , Stat3
Alzheimer Disease 18Adam10
AmnesiaIl6
Amphetamine-Related DisordersAkt1 , Fos
Amyotrophic Lateral SclerosisAkt1 , Mapk14
Amyotrophic Lateral Sclerosis 1Fos
AnemiaIl6 , Jak2
Anemia, HemolyticA2m
Anemia, Iron-DeficiencyCrp , Il6
Angina, UnstableAkt1 , Crp
AngiomyolipomaStat1 , Stat3
AnoxiaCrp
Anti-Glomerular Basement Membrane DiseaseMapk14
Antiphospholipid SyndromeCrp
Anxiety DisordersCrp , Fos
Aortic Aneurysm, ThoracicAdam10 , Adam17
Aortic Valve Disease 1Il6
Aortic Valve InsufficiencyPtpn11 , Timp1
Aortic Valve StenosisPtpn11
Aortic Valve, Calcification ofAkt1
Arrhythmias, CardiacCrp , Map2k4
Arrhythmogenic Right Ventricular DysplasiaIl6r
Arsenic PoisoningCrp , Pias1
ArteriosclerosisIl6st
Arthritis, ExperimentalA2m , Akt1 , Crp , Il6 , Il6st , Jak2 , Socs3 , Stat1 , Stat3
Arthritis, JuvenileCrp , Fos , Il6 , Jun , Stat3
Arthritis, PsoriaticStat3
Arthritis, RheumatoidA2m , Cebpb , Crp , Il6 , Il6r , Il6st , Jak2 , Stat1 , Stat3 , Tyk2
Ascorbic Acid DeficiencyIl6
AspergillosisCrp
AsphyxiaJun
AsthmaCrp , Il6 , Il6r , Irf1
AstrocytomaAkt1 , Ptpn11
Ataxia TelangiectasiaIl6 , Mitf
AtherosclerosisAkt1 , Crp , Il6 , Socs3 , Stat3
Atrial FibrillationCrp
AtrophyStat3
Autism Spectrum DisorderMapk11
Autistic DisorderIl6 , Stat3
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1Stat3
Autoimmune DiseasesIl6 , Stat3 , Timp1
Autoimmune Lymphoproliferative Syndrome, Type IIIPrkcd
BacteremiaCrp
Bacterial InfectionsCrp
Barrett EsophagusMcl1
Behcet SyndromeCrp , Il6 , Stat3
BerylliosisIl6
Beta-ThalassemiaIl6
Bile Duct NeoplasmsIl6
Biliary Tract NeoplasmsIl6
Bipolar DisorderAkt1
BlisterAdam17
Blood Coagulation DisordersFgg
Brain ConcussionIl6
Brain DeathMap2k4 , Map2k6
Brain InjuriesAkt1 , Cebpb , Crp , Fos , Il6 , Irf1 , Jak2 , Jun , Pias1 , Stat1 , Stat3 , Timp1
Brain IschemiaAkt1 , Cebpb , Il6 , Il6st , Jun , Prkcd , Stat3
Breast AdenocarcinomaAkt1 , Pik3ca
Breast NeoplasmsAdam10 , Akt1 , Crp , Fos , Il6 , Jun , Map2k4 , Myc , Pik3ca , Pik3r1 , Stat1 , Stat3 , Timp1
BronchiolitisCrp
Bronchiolitis ObliteransIl6
Bronchiolitis, ViralIl6
Budd-Chiari SyndromeJak2
Burkitt LymphomaMyc , Pik3r1
BurnsA2m , Crp , Il6 , Lbp , Prkcd , Socs3
Burns, ChemicalIl6
CachexiaIl6
Cadmium PoisoningIl6
Cafe au lait Spots, MultipleSos1
CalcinosisJak2 , Timp1
Candidiasis, Chronic MucocutaneousStat1
Candidiasis, Familial, 6Stat1
Candidiasis, Familial, 7Stat1
CarcinomaIl6st , Myc , Pik3r1 , Stat3
Carcinoma in SituAkt1
Carcinoma, Adenoid CysticPik3ca
Carcinoma, Basal CellIl6 , Pik3ca
Carcinoma, Ductal, BreastMap2k4 , Socs3
Carcinoma, EndometrioidAkt1
Carcinoma, HepatocellularA2m , Akt1 , Cebpb , Cebpd , Crp , Fos , Il6 , Il6st , Jun , Myc , Pik3ca , Rac1 , Socs3 , Stat1 , Vav1
Carcinoma, Intraductal, NoninfiltratingSocs3
Carcinoma, Merkel CellMyc
Carcinoma, Non-Small-Cell LungAkt1 , Il6r , Irf1 , Myc , Pik3ca , Stat3
Carcinoma, Renal CellAkt1 , Crp , Il6 , Il6r , Jun , Mitf , Myc , Pik3ca , Stat3 , Timp1
Carcinoma, Small CellIl6
Carcinoma, Squamous CellAkt1 , Il6 , Myc , Pik3ca , Ptpn11 , Stat3
Carcinoma, Squamous Cell of Head and NeckAkt1 , Pik3ca , Rac1 , Stat3
Carcinoma, Transitional CellAkt1 , Pik3ca , Timp1
Cardiofaciocutaneous SyndromePtpn11
CardiomegalyA2m , Akt1 , Il6 , Il6st , Map2k6 , Myc , Prkcd , Rac1 , Stat3
CardiomyopathiesAkt1 , Il6 , Mapk11 , Mapk14 , Stat3
Cardiomyopathy, DilatedPtpn11 , Rac1
Cardiomyopathy, HypertrophicMyc , Ptpn11 , Sos1
Cardiomyopathy, Hypertrophic, FamilialSos1
Cardiomyopathy, RestrictiveMap2k6 , Mapk14 , Prkcd
Cardiovascular DiseasesCrp
Carotid Artery InjuriesMyc
Celiac DiseaseIl6
Cell Transformation, NeoplasticFos , Il6 , Jun , Mitf , Myc , Rac1 , Stat3
Central Nervous System DiseasesIl6
Cerebral Small Vessel DiseasesFgg
Cervical Intraepithelial NeoplasiaStat3
CholangiocarcinomaIl6
CholangitisTimp1
CholestasisIl6 , Mapk14 , Timp1
Cholesteatoma, Middle EarIl6
ChorioamnionitisIl6
Choroidal NeovascularizationStat3
Chromosome BreakageMyc
Chronic Cerebral HypoperfusionMapk14
Chronic Lymphoid LeukemiaMyc , Ptpn11
Chronic PeriodontitisTnfsf11
Churg-Strauss SyndromeStat3
Clear-Cell Metastatic Renal Cell CarcinomaMyc
Cleft LipMyc
Cleft PalateMyc
Cocaine-Related DisordersFos , Tyk2
Cognition DisordersMapk14
ColitisAdam17 , Il6
Colitis, ExperimentalIl6
Colonic NeoplasmsA2m , Akt1 , Jun , Map2k6 , Myc , Pik3ca , Pik3r1 , Stat3
Colorectal NeoplasmsAkt1 , Crp , Il6st , Pik3ca , Pik3r1 , Ptpn11
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Conjunctival DiseasesIl6
Conjunctivitis, AllergicIrf1
Contrast-Induced NephropathyCrp
Copper-Overload CirrhosisStat3
Corneal UlcerIl6
Coronary Artery DiseaseAkt1 , Crp , Il6
Coronary RestenosisMyc
Coronavirus InfectionsIl6
Costello SyndromePtpn11
COWDEN SYNDROME 5Pik3ca
Coxsackievirus InfectionsIl6
Crohn DiseaseCrp , Il6 , Jak2 , Stat3 , Tyk2
Currarino TriadPik3ca
Cystic FibrosisIl6 , Irf1 , Timp1
Cystitis, InterstitialCrp
Cytomegalovirus InfectionsStat1
DeafnessMitf
Death, Sudden, CardiacIl6
Demyelinating DiseasesMyc
Depressive DisorderCrp , Il6 , Il6r , Jun
Dermatitis, AtopicIl6
Dermatitis, IrritantStat3
Diabetes MellitusIl6 , Rac1 , Timp1
Diabetes Mellitus, ExperimentalAkt1 , Crp , Il6 , Map2k6 , Myc , Pik3r1 , Prkcd , Socs3 , Stat1 , Stat3 , Timp1
Diabetes Mellitus, Type 1Crp , Foxo1 , Il6 , Stat3 , Timp1 , Vav1
Diabetes Mellitus, Type 2Adam17 , Akt1 , Crp , Fgg , Foxo1 , Il6 , Pik3r1 , Socs3 , Stat3 , Timp1
Diabetes, GestationalIl6
Diabetic CardiomyopathiesA2m
Diabetic FootCrp
Diabetic NephropathiesCrp , Il6 , Jak2 , Mapk14 , Stat3
Diabetic NeuropathiesMapk14
Diabetic RetinopathyCrp , Il6
Disease Models, AnimalAkt1 , Fos , Stat3 , Timp1
Disease ProgressionMyc , Stat1
Disseminated Intravascular CoagulationIl6
Dowling-Degos DiseaseAdam10
Down SyndromeTimp1
Drug-Induced Liver InjuryIl6 , Lbp
Dry Eye SyndromesIl6
Duodenal UlcerStat3
Dysfibrinogenemia, CongenitalFgg
Eales DiseaseIl6
EclampsiaIl6
EdemaIl6 , Map2k6
EmphysemaTimp1
Encephalomyelitis, Autoimmune, ExperimentalA2m , Adam17 , Il6 , Jak2 , Stat1 , Stat3
EnchondromatosisPtpn11
Endometrial NeoplasmsIrf1 , Jun , Myc , Pik3ca , Socs3 , Stat3 , Timp1
EndometriosisFos , Vav1
EndotoxemiaIl6 , Lbp , Mapk14 , Socs3
EntamoebiasisIl6
Epidermal HyperplasiaStat3
Epidermal NevusPik3ca
EpilepsyAkt1 , Fos
Epiretinal MembraneTimp1
Erectile DysfunctionAkt1 , Il6
Erythrocytosis, Familial, 1Jak2
Erythrocytosis, Familial, 2Jak2
Esophageal NeoplasmsMyc , Pik3ca
Exostoses, Multiple HereditaryPtpn11
Facial AsymmetryPik3ca
Familial Mediterranean FeverIl6
Fatty LiverCebpb , Il6 , Jak2 , Myc , Prkcd , Socs3
Fatty Liver, AlcoholicCrp
Female Urogenital DiseasesTimp1
Femoral FracturesIl6
Femur Head NecrosisA2m
Fetal Growth RetardationPtpn11
Fetal Inflammatory Response SyndromeIl6
FeverA2m , Il6 , Il6r , Stat3
Fever of Unknown OriginCrp
Fibromatosis, GingivalSos1
Fibromatosis, Gingival, 1Sos1
FibrosisAkt1 , Socs3 , Stat3
Fibrous Dysplasia of BoneFos
Foot InjuriesIl6
Gastrointestinal NeoplasmsPik3ca
Genetic Diseases, InbornJak1
Giant Cell ArteritisCrp
Giant Lymph Node HyperplasiaIl6
GingivitisIl6
Glaucoma, NeovascularIl6
GlioblastomaAkt1 , Myc , Pik3ca , Pik3r1
GliomaPik3ca
GlomerulonephritisFos , Il6
Glomerulonephritis, IGATimp1
Glomerulonephritis, MembranousA2m
Glomerulosclerosis, Focal SegmentalPias1
Glucose IntoleranceJak2
Glucosephosphate Dehydrogenase DeficiencyIl6
Granuloma, PyogenicStat3
Graves DiseaseIl6 , Il6r
Growth DisordersJak2 , Pik3ca
Growth Hormone-Secreting Pituitary AdenomaPtpn11
Hamartoma Syndrome, MultipleAkt1 , Pik3ca
Hashimoto DiseaseIl6
Head and Neck NeoplasmsPik3ca
HeadacheIl6
Hearing LossMitf , Stat1
Hearing Loss, Noise-InducedIl6
Hearing Loss, SuddenIl6
Heart ArrestAkt1
Heart DiseasesA2m , Crp , Jak2 , Mapk14 , Stat3 , Timp1
Heart FailureCrp , Fos , Foxo1 , Il6 , Il6r , Rac1 , Timp1
Heart Septal Defects, VentricularFos
Heart Valve DiseasesJak2 , Timp1
Heat Stress DisordersIl6
Heat StrokeFos , Il6 , Il6r , Jun
Helicobacter InfectionsSocs3
HemangiosarcomaJun , Myc , Stat3
HemarthrosisIl6
HematuriaFos
HemimegalencephalyPik3ca
Hemolytic-Uremic SyndromeFos , Il6
HemorrhageFos
Hepatitis C, ChronicCrp , Stat3
Hepatitis, AutoimmuneIl6
Hepatitis, ChronicStat3
Hepatolenticular DegenerationA2m , Il6 , Timp1
Hernia, DiaphragmaticIl6
Hernias, Diaphragmatic, CongenitalStat3
Heterochromia IridisMitf
HIV InfectionsCrp , Il6 , Socs3
HIV Wasting SyndromeIl6
Hodgkin DiseaseIl6 , Jun , Junb
Huntington DiseaseCebpb , Il6 , Il6r
Hyper-Ige Recurrent Infection Syndrome, Autosomal DominantStat3
HyperalgesiaFos , Il6 , Il6r , Jak2 , Stat3
HyperandrogenismIl6st
HypercalcemiaIl6 , Tnfsf11
HyperglycemiaIl6
HyperhomocysteinemiaTimp1
HyperinsulinismIl6 , Prkcd
HyperkinesisFos
HyperlipidemiasCrp
HyperoxaluriaIl6
HyperoxiaIl6 , Timp1
HyperparathyroidismMyc
Hyperparathyroidism, SecondaryCrp , Il6
HyperplasiaAkt1 , Pik3ca
HypersensitivityIl6 , Il6st , Map2k6
HypertensionAkt1 , Crp , Fos , Il6 , Il6r , Il6st , Jun , Pik3r1 , Prkcd , Timp1
Hypertension, PortalPik3r1 , Prkcd
Hypertension, PulmonaryCrp , Il6 , Myc
Hypertension, RenalCrp , Il6
Hypertensive RetinopathyCrp
HypertriglyceridemiaCrp , Il6st , Socs3
Hypertrophy, Left VentricularCrp , Myc , Prkcd , Rac1
Hypertrophy, Right VentricularAkt1 , Prkcd
HyperuricemiaJak2 , Stat3
HypoalbuminemiaA2m , Il6
Hypodysfibrinogenemia, CongenitalFgg
HypoglycemiaPik3r1
HypogonadismIl6
HypotensionIl6
Hypoxia-Ischemia, BrainCrp , Il6
Idiopathic Interstitial PneumoniasIl6
Idiopathic Pulmonary FibrosisStat3
IMMUNODEFICIENCY 31AStat1
Immunodeficiency 36Pik3r1
Infarction, Middle Cerebral ArteryCrp , Fos , Il6 , Il6r , Il6st , Junb , Stat3
InfectionCrp
Infertility, FemaleCebpb
InflammationA2m , Akt1 , Cebpb , Crp , Fgg , Il6 , Jak2 , Stat3 , Timp1
Inflammatory Bowel Disease 11Jak2 , Stat3
Inflammatory Bowel DiseasesCrp , Il6
Inflammatory Skin and Bowel Disease, NeonatalAdam17
INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL 1Adam17
Influenza, HumanCrp , Il6 , Stat1
Insulin ResistanceFoxo1 , Il6 , Il6r , Pik3r1 , Prkcd , Socs3
Intervertebral Disc DegenerationTimp1
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsPrkcd
Intestinal PolypsJun
Intestinal Reperfusion InjuryCrp , Il6 , Jak2 , Lbp
Intracranial AneurysmIl6 , Timp1
Intracranial Arteriovenous MalformationsIl6
Intracranial HemorrhagesIl6
Intraventricular HemorrhageIl6
IschemiaIl6
Ischemic Attack, TransientJak2 , Map2k4 , Stat3
Jaundice, ObstructiveLbp
Job SyndromeStat3
KeloidFgg
KeratitisIl6
Keratoconjunctivitis SiccaIl6
KeratoconusFoxo1
Keratosis, SeborrheicPik3ca
Kidney Failure, ChronicCrp , Il6
Kidney NeoplasmsAkt1 , Jun , Junb
Kidney Reperfusion InjuryFgg , Fos , Myc
Klebsiella InfectionsIl6
Learning DisordersIl6
LeiomyomaMyc
LeishmaniasisCrp , Il6 , Mcl1
Leishmaniasis, VisceralCrp , Il6
LEOPARD SyndromePtpn11
LeukemiaJak2 , Ptpn11
Leukemia, B-CellMyc
Leukemia, Large Granular LymphocyticStat3
Leukemia, Lymphocytic, Chronic, B-CellIl6 , Ptpn11 , Tnfsf11
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveJak2 , Mapk14
Leukemia, Myeloid, AcuteCebpd , Foxo1 , Il6 , Jak1 , Jak2 , Myc , Ptpn11 , Stat3
Leukemia, Myelomonocytic, JuvenilePtpn11
Leukemia, Promyelocytic, AcuteAkt1 , Myc
Leukemia, T-CellStat3
Leukemia-Lymphoma, Adult T-CellIl6 , Stat3 , Vav1
Lichenoid EruptionsIl6
Liver CirrhosisA2m , Crp , Il6 , Lbp , Stat1 , Stat3
Liver Cirrhosis, AlcoholicCrp , Il6 , Jak2 , Timp1
Liver Cirrhosis, BiliaryJak2 , Tyk2
Liver Cirrhosis, ExperimentalA2m , Adam17 , Cebpd , Crp , Fgg , Fos , Hck , Il6 , Jak2 , Lbp , Myc , Prkcd , Timp1 , Vav1
Liver DiseasesRac1 , Socs3
Liver Failure, AcuteIl6
Liver InjuryFgg , Il6 , Jak2 , Myc , Stat3
Liver NeoplasmsAkt1 , Jun , Mapk14 , Myc , Pik3ca , Stat3
Liver Neoplasms, ExperimentalIl6 , Myc , Stat3
Liver Reperfusion InjuryIl6 , Jak2 , Lbp
Low Tension GlaucomaCrp
Lung DiseasesA2m , Il6 , Irf1
Lung Diseases, ObstructiveA2m
Lung InjuryIl6
Lung NeoplasmsA2m , Akt1 , Crp , Fos , Il6 , Irf1 , Jun , Junb , Mapk14 , Mcl1 , Myc , Pik3ca
Lung Reperfusion InjuryMyc
Lupus Erythematosus, SystemicCrp , Il6 , Jak2
Lupus NephritisCrp
LymphangioleiomyomatosisStat1 , Stat3
Lymphatic MetastasisCrp , Socs3 , Stat3 , Timp1
Lymphoblastic Leukemia, Acute, with Lymphomatous FeaturesJak1 , Jak2
Lymphoma, Large B-Cell, DiffusePik3ca
Lymphoma, Large-Cell, AnaplasticJunb , Stat3
Lymphoma, Non-HodgkinMyc , Pik3ca
Lymphoma, T-CellAkt1 , Stat3
Lymphoma, T-Cell, CutaneousMcl1
LymphopeniaVav1
Lymphoproliferative DisordersStat3
Macular DegenerationCrp
Macular EdemaIl6
MalariaCrp
Malformations of Cortical DevelopmentPik3ca
Mammary Neoplasms, AnimalIl6st , Map2k6 , Pik3r1 , Stat3
Mammary Neoplasms, ExperimentalAkt1 , Il6st , Myc , Pik3r1 , Socs3 , Stat1 , Stat3
Marijuana AbuseAkt1
MastoiditisCrp
MedulloblastomaMyc , Pik3ca , Stat3 , Vav1
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromePik3ca
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca
MelanomaAkt1 , Gab2 , Mitf , Myc , Pik3ca , Pik3r1 , Rac1
Melanoma, Cutaneous MalignantMitf , Stat3
Melanoma, Cutaneous Malignant, Susceptibility To, 8Mitf
Memory DisordersStat3
Meningeal NeoplasmsAkt1
MeningiomaAkt1
MeningitisCrp
Meningitis, AsepticIl6
Meningitis, BacterialCrp
Meningitis, PneumococcalIl6
Mercury Poisoning, Nervous SystemJun
Mesenteric Vascular OcclusionJak2
Mesothelioma, MalignantIl6
Metabolic DiseasesCrp
Metabolic Syndrome XCrp , Il6 , Il6r , Lbp
MetachondromatosisPtpn11
Mevalonate Kinase DeficiencyCrp
Microphthalmia, Syndromic 1Adam17 , Mitf
Mitochondrial MyopathiesIl6
Mixed Tumor, MullerianPik3ca , Pik3r1
Mood DisordersAkt1
Mouth DiseasesCrp
Mouth NeoplasmsPik3ca
Mucocutaneous Lymph Node SyndromeCrp , Timp1
Multicystic Renal Dysplasia, BilateralTimp1
Multiple MyelomaFgg , Il6 , Mcl1 , Pik3ca , Ptpn11
Multiple Organ FailureLbp
Multiple SclerosisIl6 , Tyk2
Multiple Sclerosis, Relapsing-RemittingTimp1
Muscular AtrophyAkt1
Muscular DiseasesPrkcd
Mycobacterial and Viral Infections, Susceptibility To, Autosomal RecessiveStat1
Mycobacterium InfectionsStat1
Mycobacterium Infections, NontuberculousStat1 , Tyk2
Myelitis, TransverseIl6
Myelodysplastic SyndromesMyc
Myeloproliferative DisordersJak2
Myocardial InfarctionAkt1 , Crp , Il6 , Il6r , Jak2 , Map2k6 , Tnfsf11
Myocardial IschemiaCebpd , Crp , Il6 , Il6st , Irf1 , Jak2 , Junb , Mapk14 , Prkcd , Socs3
Myocardial Reperfusion InjuryAkt1 , Crp , Il6 , Il6r , Jak2 , Map2k6 , Mapk14 , Prkcd , Stat1 , Stat3
MyocarditisCrp , Il6 , Tnfsf11
Myocarditis, Autoimmune, ExperimentalIl6
Myoclonus, Familial CorticalMyc
Nasal PolypsJun , Stat3
Nasopharyngeal CarcinomaPik3ca
Nasopharyngeal NeoplasmsPik3ca
NecrosisIl6
Nematode InfectionsPik3r1
Neoplasm InvasivenessGab2 , Il6 , Timp1
Neoplasm MetastasisGab2 , Il6 , Myc , Rac1 , Stat3 , Timp1
NeoplasmsMyc , Pik3ca , Pik3r1
Neoplastic Syndromes, HereditaryMitf , Pik3ca
Nephritis, InterstitialCrp
Nephrotic SyndromeA2m , Jak2
Nervous System DiseasesFos
NeuroblastomaMyc , Pik3ca , Ptpn11
Neurodegenerative DiseasesIl6
Neurodevelopmental DisordersPtpn11
Neuroectodermal TumorsMyc
Neuromyelitis OpticaIl6
Neurotoxicity SyndromesFos , Prkcd
Niemann-Pick Disease, Type CJak2 , Stat3
Non-alcoholic Fatty Liver DiseaseIl6 , Jak2 , Stat3
Nonarteritic Anterior Ischemic Optic NeuropathyCrp
Nonproliferative Diabetic RetinopathyA2m
Noonan like syndromePtpn11 , Sos1
Noonan SyndromePtpn11 , Sos1
Noonan Syndrome 4Sos1
NOONAN SYNDROME 9Sos2
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaPtpn11
ObesityAkt1 , Crp , Fgg , Il6 , Il6r , Jak2 , Lbp , Myc , Pik3r1 , Prkcd , Socs3 , Stat3 , Timp1
Obstetric Labor, PrematureIl6
Optic Nerve InjuriesJun
Oral Squamous Cell CarcinomaIl6
Oral Submucous FibrosisTimp1
OrchitisIl6r
OsteoarthritisCebpb
OsteochondromaPtpn11
OsteolysisTnfsf11
OsteopetrosisJun , Tnfsf11
Osteopetrosis, Autosomal Recessive 2Tnfsf11
OsteoporosisIl6 , Il6r , Mapk14 , Myc , Tnfsf11
Osteoporosis, PostmenopausalIl6
OsteosarcomaAkt1 , Jun , Myc
Otitis ExternaCrp
Otitis MediaCrp , Il6
Ovarian Epithelial CancerPik3ca
Ovarian Hyperstimulation SyndromeIl6
Ovarian NeoplasmsAkt1 , Il6 , Il6st , Map2k4 , Map2k6 , Myc , Pik3ca , Pik3r1 , Stat3 , Timp1
Oxygen-Induced RetinopathyStat3
PainAkt1 , Il6st
Pancreatic AdenocarcinomaPik3ca
Pancreatic DiseasesIl6
Pancreatic NeoplasmsMap2k4 , Myc , Stat3
PancreatitisFgg
Pancreatitis, Acute NecrotizingIl6
Papillary Renal Cell Carcinoma, SporadicMyc , Pik3ca
PapillomaMap2k4
Paranoid DisordersTyk2
ParaplegiaAkt1
Parkinson DiseaseA2m , Akt1 , Crp , Il6
Parkinsonian DisordersPrkcd
Pasteurellaceae InfectionsCrp
Penile NeoplasmsPik3ca
Periodontal DiseasesIl6
PeriodontitisCrp , Il6 , Lbp
Peripheral Nerve InjuriesIl6 , Il6r
Peripheral Nervous System DiseasesIl6 , Jun
Peripheral Vascular DiseasesIl6
PeritonitisA2m
Pick Disease of the BrainFos , Map2k6
Pigmentation DisordersMitf
Pituitary NeoplasmsIl6st
Pleomorphic Xanthoastrocytoma Il6
Pleural DiseasesIl6
PleurisyIl6
PneumoniaCrp , Il6 , Il6st
Pneumonia, BacterialIrf1 , Stat3
Pneumonia, MycoplasmaCrp
Pneumonia, PneumococcalCrp , Il6
Polycystic Kidney Disease, Type 1Myc
Polycystic Kidney DiseasesMyc
Polycystic Kidney, Autosomal DominantFos , Myc
Polycystic Kidney, Autosomal RecessiveAkt1 , Myc , Pik3ca
Polycystic Ovary SyndromeGab1
PolycythemiaJak2
Polycythemia VeraJak1 , Jak2
Polymyalgia RheumaticaCrp
PolymyositisIl6
PolyneuropathiesIl6
Polypoidal Choroidal VasculopathyCrp
Postoperative Atrial FibrillationCrp , Il6
Pre-EclampsiaTimp1
Precancerous ConditionsAkt1 , Il6 , Stat3
Precursor B-Cell Lymphoblastic Leukemia-LymphomaStat3
Precursor Cell Lymphoblastic Leukemia-LymphomaHck , Myc
Precursor T-Cell Lymphoblastic Leukemia-LymphomaPtpn11 , Stat1 , Tyk2
Prediabetic StateIl6
Pregnancy ComplicationsJak2
Pregnancy Complications, CardiovascularIl6
Premature BirthIl6
Primary MyelofibrosisJak2
ProlactinomaCebpd , Myc
Proliferative Diabetic RetinopathyIl6r
Prostatic HyperplasiaMyc
Prostatic Intraepithelial NeoplasiaMap2k4 , Map2k6 , Myc
Prostatic NeoplasmsAkt1 , Foxo1 , Hsp90b1 , Il6 , Jak2 , Jun , Map2k4 , Map2k6 , Myc , Pik3ca , Pik3r1 , Stat1 , Stat3
ProteinuriaIl6
Proteus SyndromeAkt1
Pseudomonas Aeruginosa KeratitisIl6
Pseudomonas InfectionsCrp
PsoriasisCrp , Il6 , Stat3 , Tyk2
Psychoses, Substance-InducedAkt1
Pulmonary ContusionIl6
Pulmonary Disease, Chronic ObstructiveCrp , Il6 , Map2k4 , Timp1
Pulmonary EmbolismFgg
Pulmonary FibrosisCebpb , Il6 , Stat1 , Stat3 , Timp1
PyelonephritisCrp
QuadriplegiaIl6
RASopathiesPtpn11 , Sos1
Rectal NeoplasmsPik3ca
Renal ColicCrp
Renal FibrosisCrp , Myc
Renal InsufficiencyCrp
Reoviridae InfectionsStat1
Reperfusion InjuryAkt1 , Fos , Il6 , Il6r , Il6st , Irf1 , Jak2 , Jun , Pik3r1 , Socs3 , Stat1 , Stat3
Respiratory Distress Syndrome, AdultTimp1
Respiratory HypersensitivityIl6
Respiratory Syncytial Virus InfectionsIl6 , Irf1
Respiratory Tract InfectionsIl6r , Irf1
Reticulate Acropigmentation of KitamuraAdam10
Retina Reperfusion InjuryIl6 , Map2k4 , Stat3
Retinal Artery OcclusionIl6
Retinal DegenerationIl6st
Retinal DetachmentIl6 , Jak2
Retinal VasculitisIl6
Retinal Vein OcclusionCrp , Il6
Rhabdoid TumorMyc
Rhabdomyosarcoma, AlveolarFoxo1
Rheumatoid Arthritis, Systemic JuvenileIl6 , Il6r
Sarcoidosis, PulmonaryCrp
SarcomaMcl1 , Pik3ca
Sarcoma, KaposiIl6
SarcopeniaCebpb , Il6
SchizophreniaAkt1 , Il6 , Il6r
Sciatic NeuropathyIl6 , Il6r
Scleroderma, DiffuseIl6
Scleroderma, LimitedJak2
Scleroderma, SystemicIl6
ScrapieJak2 , Stat1 , Stat3
SeizuresFos , Il6 , Il6r , Il6st , Prkcd
SepsisA2m , Cebpb , Cebpd , Crp , Il6 , Jak2 , Lbp , Socs3 , Stat1 , Stat3
Sepsis-Associated EncephalopathyJak2 , Stat3
Septic PeritonitisIl6 , Pik3r1
Shock, HemorrhagicIl6 , Myc
Shock, SepticA2m , Il6
SHORT SyndromePik3r1
Shwartzman PhenomenonIl6
Sjogren's SyndromeCrp , Il6
Skin DiseasesIl6 , Pias1
Skin NeoplasmsAkt1 , Map2k4 , Stat3
Sleep Apnea SyndromesIl6r
Sleep Apnea, ObstructiveCrp , Il6
Sleep DeprivationMap2k4
Small Cell Lung CarcinomaAkt1 , Pik3ca
Smith-Magenis SyndromeGrb2 , Map2k6 , Socs3 , Stat3
Spinal Cord InjuriesAkt1 , Crp , Il6 , Irf1 , Jak2 , Jun
SplenomegalyIl6st
SpondylarthropathiesIl6
Spondylitis, AnkylosingCrp , Il6 , Jak2
Squamous Cell Carcinoma of the LungAkt1 , Pik3ca , Ptpn11
Status EpilepticusAdam10 , Crp , Fos , Il6st , Jun , Junb , Socs3
Stomach NeoplasmsFgg , Il6 , Il6r , Irf1 , Jun , Myc , Pik3ca , Stat3
Stomach UlcerTimp1
Stress Disorders, TraumaticCrp
StrokeAkt1 , Fgg , Il6 , Irf1 , Jak2 , Prkcd , Timp1
Subarachnoid HemorrhageStat3
Subretinal fibrosisIl6 , Il6r
Substance Withdrawal SyndromeCrp , Fos
Supranuclear Palsy, ProgressiveMap2k6
Tendon InjuriesFos
Tetralogy of FallotPtpn11
Thrombocythemia 3Jak2
Thrombocythemia, EssentialJak2
ThrombocytopeniaIl6
ThrombocytosisJak2
ThromboembolismJak2
ThrombosisCrp
Thrombotic MicroangiopathiesFgg
Thyroid NeoplasmsIl6
Thyroiditis, AutoimmuneIl6
Tibial FracturesTnfsf11
Tietz SyndromeMitf
Tietze's SyndromeMitf
Tongue NeoplasmsFos , Junb , Stat3
Toxoplasma ChorioretinitisIl6
Transplant RejectionMyc
Trauma, Nervous SystemStat1
Trigeminal NeuralgiaFos
TrypanosomiasisA2m
Tuberculosis, PulmonaryCrp , Il6 , Il6r , Irf1 , Jun
Tubulointerstitial Nephritis and UveitisCrp
Tympanic Membrane PerforationIl6
Tyrosine Kinase 2 DeficiencyTyk2
Ureteral ObstructionAkt1 , Irf1
Urinary Bladder NeoplasmsAkt1 , Map2k4 , Myc
Urinary Bladder, OveractiveCrp
UrticariaCrp
Uterine Cervical NeoplasmsAkt1 , Fos , Jak2 , Map2k6 , Myc , Pias3 , Pik3ca , Stat3
Uterine NeoplasmsPik3ca , Pik3r1 , Rac1 , Sos1
Uveal MelanomaCrp
UveitisIl6 , Il6r
Uveitis, Autoimmune, ExperimentalStat3
Uveoretinitis, Autoimmune, ExperimentalStat3
Varicose VeinsTimp1
Vascular DiseasesTimp1
Venous ThrombosisJak2
Ventilator-Induced Lung InjuryAkt1
Ventricular Dysfunction, LeftIl6
Vestibular NeuronitisCrp
Vitreoretinopathy, ProliferativeIl6
Waardenburg SyndromeMitf
Waardenburg Syndrome Type 2Mitf
Waardenburg Syndrome Type 2AMitf
Waldenstrom MacroglobulinemiaIl6
Weight GainLbp , Pik3ca
Wet Macular DegenerationCrp , Il6
Wilms TumorMyc , Stat1 , Stat3
Wounds and InjuriesIl6 , Timp1
Pathway Annotations Associated with Genes in the interleukin-6 signaling pathway
Pathway TermsGene Symbols
acenocoumarol pharmacodynamics pathwayFgg
acute myeloid leukemia pathwayAkt1 , Grb2 , Myc , Pik3ca , Pik3r1 , Sos1 , Sos2 , Stat3
adenosine signaling pathwayAkt1 , Jun , Map2k6 , Mapk11 , Pik3ca
aldosterone signaling pathwayJak2 , Pias1 , Pik3ca , Pik3r1
alteplase pharmacodynamics pathwayFgg
altered Jak-Stat signaling pathwayJak2
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Pik3ca
Alzheimer disease pathwayA2m , Adam10 , Adam17
aminocaproic acid pharmacodynamics pathwayFgg
amyotrophic lateral sclerosis disease pathwayMap2k6 , Mapk11 , Mapk14 , Rac1
angiotensin II signaling pathwayJak2
angiotensin II signaling pathway via AT1 receptorJak2 , Tyk2
anistreplase pharmacodynamics pathwayFgg
apoptotic cell death pathwayAkt1 , Pik3ca , Pik3r1
aprotinin pharmacodynamics pathwayFgg
Arf family mediated signaling pathwayRac1
argatroban pharmacodynamics pathwayFgg
ataxia telangiectasia-mutated (ATM) signaling pathwayPias1
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Fos , Grb2 , Jun , Pik3ca , Pik3r1 , Rac1 , Sos1 , Sos2 , Vav1
bivalirudin pharmacodynamics pathwayFgg
bladder cancer pathwayMyc
brain-derived neurotrophic factor signaling pathwayGrb2
c-Jun N-terminal kinases MAPK signaling pathwayMap2k4 , Rac1
cell cycle pathway, mitoticMyc
ceramide signaling pathwayAkt1 , Jak1 , Map2k4 , Myc , Pik3ca , Pik3r1 , Prkcd , Rac1 , Stat1 , Stat3
chemokine mediated signaling pathwayAkt1 , Grb2 , Hck , Jak2 , Pik3ca , Pik3r1 , Prkcd , Rac1 , Sos1 , Sos2 , Stat1 , Stat3 , Vav1
chronic myeloid leukemia pathwayAkt1 , Gab2 , Grb2 , Myc , Pik3ca , Pik3r1 , Ptpn11 , Sos1 , Sos2
classical complement pathwayCrp
coagulation cascade pathwayA2m , Fgg
codeine and morphine pharmacodynamics pathwayHsp90b1
codeine and morphine pharmacokinetics pathwayHsp90b1
colorectal cancer pathwayAkt1 , Fos , Jun , Myc , Pik3ca , Pik3r1 , Rac1
complement system pathwayA2m , Fgg
cytokine mediated signaling pathwayIl6 , Il6r , Il6st , Tnfsf11
dicoumarol pharmacodynamics pathwayFgg
E-cadherin signaling pathwayAkt1 , Pik3ca , Pik3r1 , Rac1
eicosanoid signaling pathwayAkt1 , Hck , Mapk11 , Mapk14 , Prkcd , Rac1
endometrial cancer pathwayAkt1 , Grb2 , Myc , Pik3ca , Pik3r1 , Sos1 , Sos2
Endoplasmic Reticulum-associated degradation pathwayHsp90b1
endothelin signaling pathwayAkt1 , Fos , Jak2 , Jun , Mapk14 , Prkcd , Rac1
enoxaparin pharmacodynamics pathwayFgg
Entamoeba histolyca infection pathwayIl6 , Pik3ca , Pik3r1
ephrin - ephrin receptor bidirectional signaling axisFgg , Grb2 , Hck , Map2k4 , Pik3ca , Pik3r1 , Rac1
epidermal growth factor/neuregulin signaling pathwayAdam10 , Adam17 , Akt1 , Gab1 , Grb2 , Jun , Map2k4 , Myc , Pik3ca , Pik3r1 , Ptpn11 , Sos1 , Sos2 , Stat1 , Stat3
erythropoietin signaling pathwayGab1 , Grb2 , Jak2 , Mapk14 , Pik3r1 , Ptpn11 , Socs3 , Sos1 , Stat1
etoposide pharmacodynamics pathwayHsp90b1
etoposide pharmacokinetics pathwayHsp90b1
FasL mediated signaling pathwayAkt1 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1
Fc epsilon receptor mediated signaling pathwayAkt1 , Gab2 , Grb2 , Map2k4 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Prkcd , Rac1 , Sos1 , Sos2 , Vav1
Fc gamma receptor mediated signaling pathwayAkt1 , Gab2 , Hck , Pik3ca , Pik3r1 , Prkcd , Rac1 , Vav1
fibrinolysis pathwayFgg
fibroblast growth factor signaling pathwayAkt1 , Fos , Gab1 , Grb2 , Jun , Pik3ca , Pik3r1 , Ptpn11 , Sos1 , Stat1
fondaparinux pharmacodynamics pathwayFgg
forkhead class A signaling pathwayAkt1 , Cebpb , Cebpd , Fos , Jun
glioma pathwayAkt1 , Grb2 , Pik3ca , Pik3r1 , Sos1 , Sos2
glypican signaling pathwayHck
gonadotropin-releasing hormone signaling pathwayGrb2 , Jun , Map2k4 , Map2k6 , Mapk11 , Mapk14 , Prkcd , Sos1 , Sos2
graft-versus-host disease pathwayIl6
granulocyte-macrophage colony-stimulating factor signaling pathwayFos , Gab2 , Grb2 , Jak2 , Pik3ca , Pik3r1 , Ptpn11 , Sos1 , Stat1 , Stat3
growth hormone signaling pathwayJak2
Hedgehog signaling pathwayAkt1 , Pias1 , Pik3ca , Pik3r1 , Prkcd
heparin pharmacodynamics pathwayFgg
hepatitis C virus infection pathwayAkt1 , Grb2 , Irf1 , Jak1 , Mapk11 , Mapk14 , Pias1 , Pias3 , Pik3ca , Pik3r1 , Socs3 , Sos1 , Sos2 , Stat1 , Stat3
hypertrophic cardiomyopathy pathwayIl6
hypoxia inducible factor pathwayAkt1 , Fos , Jun , Mcl1
ibuprofen pharmacodynamics pathwayHsp90b1
ibuprofen pharmacokinetics pathwayHsp90b1
immune response pathwayA2m
inflammatory response pathwayA2m
influenza A virus infection pathwayAkt1 , Il6 , Jak1 , Jak2 , Jun , Map2k4 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Socs3 , Stat1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Rac1
insulin signaling pathwayAkt1 , Foxo1 , Grb2 , Pik3ca , Pik3r1 , Ptpn11 , Socs3 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Grb2 , Pik3ca , Pik3r1 , Prkcd , Ptpn11 , Sos1
interleukin-1 signaling pathwayJun , Map2k6 , Pik3ca , Pik3r1
Interleukin-10 signaling pathwayJak1 , Stat1 , Stat3 , Tyk2
interleukin-12 signaling pathwayFos , Jak2 , Map2k6 , Mapk14 , Stat1 , Stat3 , Tyk2
interleukin-2 signaling pathwayFos , Gab2 , Grb2 , Jak1 , Jun , Mapk11 , Mapk14 , Myc , Pik3ca , Pik3r1 , Ptpn11 , Socs3 , Sos1 , Stat1 , Stat3
interleukin-23 signaling pathwayIl6 , Jak2 , Pik3ca , Pik3r1 , Socs3 , Stat1 , Stat3 , Tyk2
interleukin-27 signaling pathwayIl6 , Il6st , Jak1 , Jak2 , Stat1 , Stat3 , Tyk2
interleukin-3 signaling pathwayCebpb , Gab2 , Grb2 , Jak2 , Pik3ca , Pik3r1 , Ptpn11
interleukin-4 signaling pathwayAkt1 , Cebpb , Grb2 , Jak1 , Jak2 , Mapk14 , Pik3ca , Pik3r1 , Socs3
interleukin-5 signaling pathwayGrb2 , Jak2 , Pik3ca , Pik3r1 , Ptpn11
interleukin-6 signaling pathwayA2m , Adam10 , Adam17 , Akt1 , Cebpb , Cebpd , Crp , Fgg , Fos , Foxo1 , Gab1 , Gab2 , Grb2 , Hck , Hsp90b1 , Il6 , Il6r , Il6st , Irf1 , Jak1 , Jak2 , Jun , Junb , Lbp , Lmo4 , Map2k4 , Map2k6 , Mapk11 , Mapk14 , Mcl1 , Mitf , Myc , Pias1 , Pias3 , Pik3ca , Pik3r1 , Prkcd , Ptpn11 , Rac1 , Socs3 , Sos1 , Sos2 , Stat1 , Stat3 , Timp1 , Tnfsf11 , Tyk2 , Vav1
intrinsic apoptotic pathwayMcl1
irinotecan pharmacodynamics pathwayHsp90b1
irinotecan pharmacokinetics pathwayHsp90b1
Jak-Stat signaling pathwayAkt1 , Grb2 , Il6 , Il6r , Il6st , Irf1 , Jak1 , Jak2 , Myc , Pias1 , Pias3 , Pik3ca , Pik3r1 , Ptpn11 , Socs3 , Sos1 , Sos2 , Stat1 , Stat3 , Tyk2
kallikrein-kinin cascade pathwayA2m
Leishmania infection pathwayFos , Jak1 , Jak2 , Jun , Mapk11 , Mapk14 , Stat1
leptin system pathwayJak2 , Ptpn11 , Socs3 , Stat3
measles infection pathwayAkt1 , Il6 , Jak1 , Jak2 , Pik3ca , Pik3r1 , Stat1 , Stat3
melanoma pathwayAkt1 , Mitf , Pik3ca , Pik3r1
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mitogen activated protein kinase signaling pathwayAkt1 , Fos , Grb2 , Jun , Map2k4 , Map2k6 , Mapk11 , Mapk14 , Myc , Rac1 , Sos1 , Sos2
mTOR signaling pathwayAkt1 , Pik3ca , Pik3r1 , Rac1
Mycobacterium tuberculosis infection pathwayAkt1 , Cebpb , Il6 , Jak1 , Jak2 , Lbp , Mapk11 , Mapk14 , Stat1
myocarditis pathwayRac1
N-cadherin signaling pathwayPik3ca , Pik3r1 , Ptpn11 , Rac1
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Gab1 , Grb2 , Jun , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Prkcd , Ptpn11 , Rac1 , Sos1 , Sos2
NOD-like receptor signaling pathwayHsp90b1 , Il6 , Mapk11 , Mapk14
non-small cell lung cancer pathwayAkt1 , Grb2 , Pik3ca , Pik3r1 , Sos1 , Sos2
Non-Stat, Jak dependent pathwayJak1 , Tyk2
Notch signaling pathwayAdam10 , Adam17 , Myc
nuclear factor kappa B signaling pathwayIrf1 , Mapk14 , Pik3ca , Pik3r1
p38 MAPK signaling pathwayIrf1 , Map2k6 , Mapk11 , Mapk14 , Rac1
p53 signaling pathwayAkt1 , Mapk14 , Prkcd
pancreatic cancer pathwayAkt1 , Jak1 , Pik3ca , Pik3r1 , Rac1 , Stat1 , Stat3
paracetamol pharmacokinetics pathwayHsp90b1
phagocytosis pathwayRac1
phenindione pharmacodynamics pathwayFgg
phenytoin pharmacodynamics pathwayHsp90b1
phosphatidylinositol 3-kinase class I signaling pathwayHck , Pik3ca , Pik3r1 , Rac1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3r1
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Foxo1 , Pik3ca , Pik3r1
phosphoinositide metabolic pathwayPik3ca , Pik3r1
Plasmodium infection pathwayIl6
platelet-derived growth factor signaling pathwayFos , Gab1 , Grb2 , Hck , Jak1 , Jak2 , Jun , Map2k4 , Myc , Pik3ca , Pik3r1 , Prkcd , Ptpn11 , Rac1 , Sos1 , Stat1 , Stat3
prion diseases pathwayIl6
prostate cancer pathwayAkt1 , Foxo1 , Grb2 , Hsp90b1 , Pik3ca , Pik3r1 , Sos1 , Sos2
protein kinase C (PKC) signaling pathwayPrkcd
Ras family mediated signaling pathwaySos1
Reelin signaling pathwayAkt1 , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Gab1 , Grb2 , Jun , Pik3ca , Pik3r1 , Ptpn11 , Rac1 , Sos1 , Sos2
reteplase pharmacodynamics pathwayFgg
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMapk11 , Mapk14
retinol metabolic pathwayHsp90b1
rheumatoid arthritis disease pathwayFos , Il6 , Jun , Tnfsf11
Rho/Rac/Cdc42 mediated signaling pathwayJun , Map2k4 , Rac1
scatter factor/hepatocyte growth factor signaling pathwayGab1 , Grb2 , Pik3r1 , Ptpn11
small cell lung cancer pathwayAkt1 , Myc , Pias1 , Pias3 , Pik3ca , Pik3r1
somatostatin signaling pathwayJak2 , Ptpn11
sorafenib pharmacokinetics pathwayHsp90b1
sphingosine 1-phosphate signaling pathwayAkt1 , Fos , Jak2 , Jun , Mapk14 , Rac1
Staphylococcus aureus infection pathwayFgg
sumoylation pathwayPias3
syndecan signaling pathwayPrkcd , Rac1
T cell receptor signaling pathwayAkt1 , Fos , Grb2 , Jun , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Sos1 , Sos2 , Vav1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayPrkcd
thyroid cancer pathwayMyc
tioguanine pharmacodynamics pathwayRac1
Toll-like receptor signaling pathwayAkt1 , Fos , Il6 , Jun , Lbp , Map2k4 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Rac1 , Stat1
Toxoplasma gondii infection pathwayAkt1 , Jak1 , Jak2 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Stat1 , Stat3
Trail mediated signaling pathwayMap2k4 , Pik3ca , Pik3r1
tranexamic acid pharmacodynamics pathwayFgg
transforming growth factor-beta Smad dependent signaling pathwayA2m , Foxo1 , Grb2 , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayMyc
Trypanosoma brucei infection pathwayIl6
Trypanosoma cruzi infection pathwayAkt1 , Fos , Il6 , Jun , Map2k4 , Mapk11 , Mapk14 , Pik3ca , Pik3r1
tumor necrosis factor mediated signaling pathwayAdam17 , Stat1
type 2 diabetes mellitus pathwayPik3ca , Pik3r1 , Prkcd , Socs3
type II interferon signaling pathwayAkt1 , Cebpb , Irf1 , Jak1 , Jak2 , Pias1 , Pik3ca , Pik3r1 , Prkcd , Ptpn11 , Stat1 , Stat3
ubiquitin/proteasome degradation pathwayPias1 , Pias3 , Socs3
vascular endothelial growth factor signaling pathwayAkt1 , Gab1 , Grb2 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Prkcd , Ptpn11 , Rac1
vitamin A deficiency pathwayHsp90b1
warfarin pharmacodynamics pathwayFgg
Wnt signaling pathwayJun , Myc , Rac1
Wnt signaling, non-canonical pathwayRac1
Wnt signaling, the planar cell polarity pathwayRac1
Phenotype Annotations Associated with Genes in the interleukin-6 signaling pathway

References Associated with the interleukin-6 signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: