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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731433
Species: Mus musculus
RGD Object: Gene
Symbol: Timp1
Name: tissue inhibitor of metalloproteinase 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp1increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of TIMP1 mRNA; Lipopolysaccharides results in increased expression of TIMP1 proteinPMID:19133137 PMID:22169119 PMID:23585870
Timp1multiple interactionsEXP 6480464CTD2-chloro-5-nitrobenzanilide promotes the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 mRNA]]; 2-chloro-5-nitrobenzanilide promotes the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 protein]]; [IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 mRNA; [IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 protein; IL4 protein inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 mRNA]; IL4 protein inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 protein]; terameprocol inhibits the reaction [Lipopolysaccharides results in increased expression of TIMP1 protein]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 protein]PMID:19133137 PMID:37019307
Timp1increases expressionISOTIMP1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of TIMP1 proteinPMID:31935363
Timp1multiple interactionsISOTIMP1 (Homo sapiens)6480464CTD2,5-dimethyl-4-benzoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TIMP1 protein]; 2-tert-butyl-4-quinone inhibits the reaction [Lipopolysaccharides results in increased expression of TIMP1 protein]; phenylbenzoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TIMP1 protein]; thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TIMP1 protein]PMID:31935363
Timp1multiple interactionsISOTimp1 (Rattus norvegicus)6480464CTD[sodium arsenite co-treated with Lipopolysaccharides] results in increased expression of TIMP1 mRNA; SERPINH1 protein promotes the reaction [[sodium arsenite co-treated with Lipopolysaccharides] results in increased expression of TIMP1 mRNA]PMID:35963424
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