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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731433
Species: Mus musculus
RGD Object: Gene
Symbol: Timp1
Name: tissue inhibitor of metalloproteinase 1
Acc ID: CHEBI:30563
Term: silicon dioxide
Definition: A silicon oxide made up of linear triatomic molecules in which a silicon atom is covalently bonded to two oxygens.
Chemical ID: MESH:D012822
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp1increases expressionEXP 6480464CTDSilicon Dioxide results in increased expression of TIMP1 mRNA; Silicon Dioxide results in increased expression of TIMP1 proteinPMID:23221170 PMID:26345256 PMID:27428020 PMID:29341224
Timp1multiple interactionsEXP 6480464CTD[SOD3 gene mutant form results in increased susceptibility to Silicon Dioxide] which results in increased expression of TIMP1 mRNAPMID:30453980
Timp1affects secretionISOTIMP1 (Homo sapiens)6480464CTDSilicon Dioxide analog affects the secretion of TIMP1 proteinPMID:25895662
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