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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731433
Species: Mus musculus
RGD Object: Gene
Symbol: Timp1
Name: tissue inhibitor of metalloproteinase 1
Acc ID: CHEBI:9927
Term: valsartan
Definition: A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.
Chemical ID: MESH:C081489
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp1decreases expressionISOTimp1 (Rattus norvegicus)6480464CTDValsartan results in decreased expression of TIMP1 mRNA; Valsartan results in decreased expression of TIMP1 proteinPMID:21051829
Timp1multiple interactionsISOTIMP1 (Homo sapiens)6480464CTDValsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 protein]PMID:12846741
Timp1multiple interactionsISOTimp1 (Rattus norvegicus)6480464CTD[Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 protein; Valsartan inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]PMID:15504291 PMID:21051829
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