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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731433
Species: Mus musculus
RGD Object: Gene
Symbol: Timp1
Name: tissue inhibitor of metalloproteinase 1
Acc ID: CHEBI:3139
Term: bleomycin A2
Definition: A bleomycin that has formula C55H84N17O21S3.
Chemical ID: MESH:D001761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp1increases expressionEXP 6480464CTDBleomycin results in increased expression of TIMP1 mRNA; Bleomycin results in increased expression of TIMP1 proteinPMID:26345256 PMID:28300665 PMID:32032644
Timp1multiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [Bleomycin results in increased expression of TIMP1 protein]; Grape Seed Extract inhibits the reaction [Bleomycin results in increased expression of TIMP1 protein]; honokiol inhibits the reaction [Bleomycin results in increased expression of TIMP1 protein]PMID:28300665 PMID:32032644
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