Tgfb1 (transforming growth factor, beta 1) - Rat Genome Database

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Gene: Tgfb1 (transforming growth factor, beta 1) Mus musculus
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Symbol: Tgfb1
Name: transforming growth factor, beta 1
RGD ID: 69096
MGI Page MGI
Description: Enables protein serine/threonine kinase activator activity and transforming growth factor beta receptor binding activity. Involved in several processes, including circulatory system development; positive regulation of leukocyte differentiation; and regulation of cytokine production. Acts upstream of or within several processes, including branching involved in mammary gland duct morphogenesis; leukocyte differentiation; and regulation of protein localization to nucleus. Located in cytoplasm; extracellular matrix; and extracellular space. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and skin. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; artery disease (multiple); bone disease (multiple); carcinoma (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: regulatory protein; TGF-beta; TGF-beta 1; TGF-beta-1; TGF-beta1; Tgfb; Tgfb-1; TGFbeta; TGFbeta1; transforming growth factor beta-1; transforming growth factor beta-1 proprotein; transforming growth factor-beta 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,386,406 - 25,404,503 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,386,427 - 25,404,502 (+)EnsemblGRCm39 Ensembl
GRCm38725,687,002 - 25,705,077 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,687,002 - 25,705,077 (+)EnsemblGRCm38mm10GRCm38
MGSCv37726,472,021 - 26,490,015 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,395,762 - 25,413,756 (+)NCBIMGSCv36mm8
Celera720,295,914 - 20,313,908 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acromicric dysplasia  (ISO)
actinic keratosis  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (IMP,ISO)
adenocarcinoma  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic conjunctivitis  (IMP)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Anetoderma  (ISO)
anogenital venereal wart  (ISO)
aortic valve insufficiency  (ISO)
aphthous stomatitis  (ISO)
aplastic anemia  (ISO)
arteriosclerosis  (ISO)
asthma  (IEP,IMP,ISO)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bacterial pneumonia  (IEP)
Behcet's disease  (ISO)
berylliosis  (ISO)
biliary atresia  (ISO)
brain disease  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Cachexia  (ISO)
calcinosis  (ISO)
Camurati-Engelmann disease  (ISO)
carcinoma  (ISO)
carcinosarcoma  (ISO)
Cardiac Fibrosis  (IMP,ISO)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
Carpenter Syndrome 2  (ISO)
Chemical and Drug Induced Liver Injury  (IEP)
chlamydia  (ISO)
cholangiocarcinoma  (ISO)
chorioamnionitis  (ISO)
Chronic Experimental Pancreatitis  (ISO)
Chronic Hepatitis  (ISO)
Chronic Hepatitis B  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
cleft palate  (ISO)
colon adenocarcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital hypoplastic anemia  (ISO)
Copper-Overload Cirrhosis  (ISO)
coronary artery disease  (ISO)
craniosynostosis  (ISO)
cystic fibrosis  (ISO)
degenerative disc disease  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IEP,ISO)
diabetic neuropathy  (ISO)
Diamond-Blackfan anemia  (ISO)
Diaphragmatic Hernia  (ISO)
Dilatation, Pathologic  (ISO)
dry eye syndrome  (ISO)
Duchenne muscular dystrophy  (ISO)
duodenal ulcer  (ISO)
Ehlers-Danlos syndrome  (ISO)
end stage renal disease  (ISO)
endomyocardial fibrosis  (ISO)
eosinophilic esophagitis  (ISO)
epilepsy  (ISO)
essential thrombocythemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IMP)
extrahepatic cholestasis  (ISO)
factor VIII deficiency  (ISO)
familial hyperlipidemia  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
Gallbladder Neoplasms  (ISO)
genetic disease  (ISO)
gout  (ISO)
Graves' disease  (ISO)
heart disease  (ISO)
Heart Injuries  (IEP)
Hemorrhagic Shock  (ISO)
hepatic encephalopathy  (IEP)
Hepatic Insufficiency  (ISO)
hepatocellular carcinoma  (IEP,ISO)
Hepatomegaly  (ISO)
Hereditary Hemorrhagic Telangiectasia, Type 1  (ISO)
Hyperoxia  (IEP,ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (IMP)
hyperuricemia  (ISO)
IgA glomerulonephritis  (ISO)
impotence  (ISO)
Infant, Newborn, Diseases  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHY  (ISO)
insulinoma  (ISO)
interstitial lung disease  (ISO)
Joubert syndrome 1  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (IEP)
liver cirrhosis  (ISO)
localized scleroderma  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
Lymphomatoid Papulosis  (ISO)
maple syrup urine disease  (ISO)
Meckel Syndrome 10  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (IEP,ISO)
multiple myeloma  (ISO)
muscular disease  (ISO)
myelofibrosis  (IEP,IMP,ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrolithiasis  (ISO)
nephrosclerosis  (ISO)
nephrotic syndrome  (ISO)
nephrotoxicity  (ISO)
Neuralgia  (ISO)
obesity  (ISO)
occupational asthma  (ISO)
Occupational Diseases  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
osteochondrodysplasia  (ISO)
osteoporosis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal adenocarcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
papilloma  (IEP,ISO)
Paraquat Lung  (ISO)
Peritoneal Fibrosis  (ISO)
Peyronie's disease  (ISO)
pleural disease  (ISO)
pneumonia  (IEP,ISO)
Posterior Leukoencephalopathy Syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
primary biliary cholangitis  (ISO)
Progressive Diaphyseal Dysplasia 1  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (IDA,IEP,ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
Radiation Pneumonitis  (ISO)
renal cell carcinoma  (ISO)
rhinitis  (ISO)
Right Ventricular Hypertrophy  (ISO)
sarcoidosis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
sickle cell anemia  (ISO)
Sjogren's syndrome  (IAGP,IEP,IMP)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (ISO)
Spontaneous Neoplasm Regression  (ISO)
squamous cell carcinoma  (ISO)
Stroke  (ISO)
thrombocytopenia  (IEP)
tracheal stenosis  (ISO)
traumatic brain injury  (ISO)
Tubulointerstitial Fibrosis  (IEP,ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
urethral obstruction  (ISO)
urticaria  (ISO)
uveitis  (ISO)
Ventricular Remodeling  (ISO)
vitiligo  (ISO)
Wallerian Degeneration  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-taxifolin  (ISO)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (EXP)
(20S)-ginsenoside Rg3  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-amygdalin  (EXP,ISO)
(R)-carnitine  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3,5-trinitrobenzene  (EXP)
1,3,7,9-tetramethyluric acid  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-Hydroxypyrene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-stearoyl-2-arachidonoyl-sn-glycerol  (ISO)
14,15-EET  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (ISO)
2,5-dihydroxybenzoic acid  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
20-HETE  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
26-hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-(1H-indol-3-yl)propanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
4-phenylbutyric acid  (EXP)
5'-S-methyl-5'-thioadenosine  (EXP)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aminoimidazole-4-carboxamide  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP,ISO)
5-fluorouracil  (EXP,ISO)
5-Hydroxycapric acid  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-aminonicotinamide  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-[3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid  (EXP)
7H-xanthine  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (EXP,ISO)
9H-xanthine  (ISO)
acetaldehyde  (EXP,ISO)
acetamide  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
aconitic acid  (EXP,ISO)
acrylamide  (EXP,ISO)
acteoside  (ISO)
actinomycin D  (ISO)
adefovir  (ISO)
adenine  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
alendronic acid  (ISO)
alfacalcidol  (ISO)
Alisol B  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allantoin  (ISO)
allethrin  (ISO)
allyl alcohol  (ISO)
alpha-D-galactose  (ISO)
alpha-naphthoflavone  (ISO)
aluminium atom  (ISO)
aluminium hydroxide  (EXP)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
AM-251  (ISO)
ambroxol  (ISO)
aminoguanidine  (EXP,ISO)
amiodarone  (ISO)
amitrole  (ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
Ammothamnine  (EXP,ISO)
amodiaquine  (EXP)
amosite asbestos  (ISO)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
anagrelide  (ISO)
andrastin A  (EXP)
androgen antagonist  (ISO)
andrographolide  (EXP,ISO)
aniline  (ISO)
anthocyanin  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracene-1,8,9-triol  (EXP)
antimycin A  (ISO)
ANTU  (ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (EXP,ISO)
aristolochic acids  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
asbestos  (EXP,ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atropine  (ISO)
aucubin  (ISO)
Aurothioglucose  (EXP)
azathioprine  (ISO)
azoxystrobin  (ISO)
baicalein  (EXP,ISO)
baicalin  (ISO)
bellidifolin  (EXP,ISO)
benazepril  (ISO)
benzalkonium chloride  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
Benzoyl peroxide  (EXP)
berberine  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
Betanin  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bezafibrate  (EXP,ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
Bisibuthiamine  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP,ISO)
boric acid  (EXP,ISO)
bosentan  (ISO)
Brevianamide A  (EXP)
bromocriptine  (ISO)
bucladesine  (ISO)
budesonide  (EXP)
busulfan  (ISO)
buta-1,3-diene  (EXP)
Butylbenzyl phthalate  (EXP)
Butylparaben  (ISO)
butyric acid  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
caffeine  (ISO)
Calcimycin  (EXP)
calciol  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium dichloride  (ISO)
calcium silicate  (EXP)
calcium(0)  (ISO)
calycosin  (ISO)
camostat  (EXP,ISO)
candesartan  (ISO)
Candesartan cilexetil  (ISO)
canertinib  (ISO)
cannabidiol  (EXP,ISO)
Cannabidivarin  (EXP)
cantharidin  (ISO)
capsaicin  (ISO)
captopril  (ISO)
carbamazepine  (ISO)
Carbaprostacyclin  (ISO)
carbofuran  (ISO)
carbon atom  (ISO)
carbon disulfide  (EXP)
carbon nanotube  (EXP,ISO)
carfilzomib  (ISO)
carmustine  (ISO)
carnosine  (ISO)
carrageenan  (EXP)
carteolol  (ISO)
carvedilol  (EXP,ISO)
cefoxitin  (EXP)
celastrol  (ISO)
celecoxib  (ISO)
cerium trichloride  (EXP)
ceruletide  (EXP)
cetrorelix  (ISO)
Chebulagic acid  (ISO)
chenodeoxycholic acid  (EXP)
chlorothalonil  (ISO)
chlorpyrifos  (EXP,ISO)
cholate  (ISO)
cholesterol  (EXP,ISO)
choline  (EXP)
chromium atom  (ISO)
chrysin  (EXP)
ciglitazone  (ISO)
cilazapril monohydrate  (ISO)
cilnidipine  (ISO)
cinaciguat  (ISO)
Cinobufagin  (ISO)
ciprofloxacin  (ISO)
cisatracurium  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (EXP)
clofibrate  (ISO)
Clofop  (ISO)
clopidogrel  (EXP)
clotrimazole  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
coenzyme Q10  (ISO)
colforsin daropate hydrochloride  (ISO)
colistin  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (ISO)
corilagin  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (ISO)
cucurbitacin B  (EXP)
cumene hydroperoxide  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (ISO)
dapsone  (EXP)
DAPT  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
delphinidin  (EXP,ISO)
Delta(9)-tetrahydrocannabinolic acid  (EXP)
deoxynivalenol  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
diazoxide  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
Didecyldimethylammonium  (EXP)
dieckol  (EXP)
dieldrin  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
dihydrolipoic acid  (ISO)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethyl fumarate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
Diosbulbin B  (EXP)
dioscin  (EXP,ISO)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
disodium cromoglycate  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dobutamine  (ISO)
domperidone  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
Droloxifene  (ISO)
ebselen  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
edaravone  (ISO)
elemental carbon  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (ISO)
emetine  (ISO)
emodin  (ISO)
enalapril  (ISO)
enalaprilat dihydrate  (ISO)
endosulfan  (ISO)
enzacamene  (ISO)
eplerenone  (ISO)
epoxiconazole  (ISO)
eprosartan  (ISO)
erlotinib hydrochloride  (ISO)
esculetin  (ISO)
estriol  (EXP)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
eticlopride(1+)  (ISO)
farrerol  (ISO)
fasudil  (EXP,ISO)
fenofibrate  (EXP,ISO)
fenoldopam  (ISO)
fenoprofen  (ISO)
fenthion  (EXP)
fentin hydroxide  (ISO)
fenvalerate  (ISO)
ferbam  (ISO)
ferulic acid  (ISO)
fingolimod hydrochloride  (EXP)
flavonoids  (ISO)
flubendazole  (ISO)
fluoranthene  (ISO)
fluorene  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fosinopril  (EXP)
fragrance  (ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (EXP)
furosemide  (ISO)
gadodiamide hydrate  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (EXP,ISO)
galactose  (ISO)
galangin  (ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
Ganoderic acid A  (EXP)
gemcitabine  (ISO)
Geniposide  (EXP)
genistein  (ISO)
gentamycin  (EXP,ISO)
geraniol  (ISO)
ghrelin  (EXP)
Ginkgoic acid  (EXP)
ginsenoside Rb1  (ISO)
glucagon  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (ISO)
glycerol  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (ISO)
graphene oxide  (ISO)
guggulsterone  (ISO)
GW 501516  (EXP)
gypenoside LXXV  (EXP)
heparin  (ISO)
heptachlor  (ISO)
hesperetin  (ISO)
hexachlorobenzene  (EXP,ISO)
hexacosan-1-ol  (ISO)
hexadecanoic acid  (EXP,ISO)
Honokiol  (EXP,ISO)
HU-308  (EXP,ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (ISO)
icariin  (ISO)
Icaritin  (EXP,ISO)
icatibant  (ISO)
idelalisib  (EXP)
imiquimod  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (ISO)
indoxyl sulfate  (ISO)
iohexol  (ISO)
ionomycin  (ISO)
irbesartan  (ISO)
iron atom  (ISO)
iron dextran  (ISO)
iron(0)  (ISO)
iron(III) nitrilotriacetate  (ISO)
Isoangustone A  (ISO)
isoliquiritigenin  (EXP)
isoorientin  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
ketamine  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (ISO)
L-methionine  (EXP,ISO)
lactacystin  (ISO)
lamivudine  (ISO)
lansoprazole  (EXP)
lapatinib  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lead(II) chloride  (EXP)
lenalidomide  (EXP)
letrozole  (ISO)
leukotriene B4  (EXP)
leukotriene D4  (ISO)
lidocaine  (ISO)
lignan  (EXP)
lignin  (EXP)
limonene  (ISO)
linagliptin  (ISO)
linoleic acid  (EXP)
linsidomine  (ISO)
linuron  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lithocholic acid  (EXP,ISO)
loganin  (EXP)
losartan  (EXP,ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY-2157299  (EXP,ISO)
LY294002  (EXP,ISO)
malonaldehyde  (ISO)
maneb  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
manganese(II) sulfate  (ISO)
mangiferin  (EXP,ISO)
manumycin A  (ISO)
masitinib  (ISO)
masoprocol  (ISO)
mebendazole  (ISO)
melamine  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP)
melphalan  (EXP)
mercury diacetate  (ISO)
mercury dichloride  (ISO)
mesalamine  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
Methanandamide  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylglyoxal  (EXP,ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
methylxanthine  (ISO)
metoprolol  (ISO)
metronidazole  (EXP)
Mezerein  (EXP)
minocycline  (ISO)
mirtazapine  (EXP,ISO)
mithramycin  (ISO)
mitogen  (ISO)
mitomycin C  (ISO)
Mitotane  (ISO)
monocrotaline  (ISO)
morin  (ISO)
morphine  (EXP)
Morroniside  (EXP,ISO)
mycophenolic acid  (ISO)
myricetin  (ISO)
myricitrin  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-nitrosomorpholine  (ISO)
N-oleoyldopamine  (ISO)
N-palmitoyl dopamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N-Vinyl-2-pyrrolidone  (ISO)
naproxen  (ISO)
naringin  (EXP,ISO)
nemorubicin  (ISO)
neoechinulin A  (EXP)
nerolidol  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nifedipine  (ISO)
nifuroxazide  (ISO)
nilotinib  (ISO)
nitrates  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
nitrogen dioxide  (ISO)
NS-398  (ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (EXP,ISO)
octreotide  (ISO)
olaparib  (EXP)
oleanolic acid  (EXP)
oleic acid  (ISO)
olmesartan  (ISO)
Olmesartan medoxomil  (ISO)
olodaterol  (ISO)
omeprazole  (EXP)
Ophiopogonin D  (ISO)
oridonin  (ISO)
orlistat  (ISO)
osthole  (EXP,ISO)
ouabain  (ISO)
oxalic acid  (ISO)
Oxotremorine  (ISO)
ozone  (EXP,ISO)
Pachymic acid  (ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (ISO)
palbociclib  (ISO)
Palmitic acid(d3)  (ISO)
pantoprazole  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paricalcitol  (ISO)
patulin  (ISO)
PCB138  (ISO)
PD 168393  (ISO)
Pentoxifylline  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP,ISO)
permethrin  (ISO)
peroxides  (ISO)
phenanthrene  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phloroglucinol  (ISO)
Phomenone  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidylcholine  (ISO)
Phyllanthin  (EXP)
pioglitazone  (EXP,ISO)
pirfenidone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (EXP,ISO)
plumbagin  (ISO)
poly(I:C)  (ISO)
poly(methyl methacrylate) macromolecule  (ISO)
potassium chromate  (EXP,ISO)
potassium iodide  (ISO)
prazosin  (ISO)
prednisolone  (ISO)
prednisone  (ISO)
pregabalin  (ISO)
proanthocyanidin  (ISO)
probenecid  (ISO)
probucol  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
propane-1,2-diol  (EXP)
prostaglandin D2  (EXP)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (ISO)
protoporphyrinogen  (ISO)
puerarin  (EXP,ISO)
pyrethrins  (ISO)
pyridoxamine  (ISO)
pyrrolidine dithiocarbamate  (ISO)
pyrvinium  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
ramipril  (EXP,ISO)
raspberry ketone  (ISO)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
rifaximin  (EXP)
rimonabant  (ISO)
rivaroxaban  (ISO)
Ro 31-8220  (ISO)
rolipram  (ISO)
rosmarinic acid  (ISO)
rosuvastatin calcium  (EXP,ISO)
rotenone  (EXP,ISO)
rutin  (EXP,ISO)
S-adenosyl-L-methioninate  (EXP,ISO)
S-adenosyl-L-methionine  (EXP,ISO)
S-allylcysteine  (ISO)
Salidroside  (ISO)
Salinomycin  (ISO)
salubrinal  (ISO)
salvianolic acid B  (ISO)
saroglitazar  (ISO)
sarpogrelate  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (EXP,ISO)
SCH772984  (EXP)
selenium atom  (EXP,ISO)
senecionine  (EXP)
serotonin  (EXP)
serpentine asbestos  (EXP,ISO)
sevoflurane  (EXP)
sildenafil citrate  (EXP,ISO)
silibinin  (ISO)
silicon atom  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
Sinomenine  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium acetate trihydrate  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium cholate  (ISO)
sodium fluoride  (EXP,ISO)
sodium hydrogencarbonate  (ISO)
sodium nitrite  (ISO)
sodium propionate  (EXP)
sodium stibogluconate  (ISO)
sodium tungstate  (ISO)
sorafenib  (EXP,ISO)
spironolactone  (ISO)
SR 144528  (ISO)
stattic  (EXP,ISO)
sterigmatocystin  (ISO)
streptozocin  (EXP,ISO)
styrene  (EXP)
succimer  (ISO)
sulfates  (ISO)
sulforaphane  (EXP)
sulfur dioxide  (ISO)
sulindac  (ISO)
sumatriptan  (ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
tacrolimus hydrate  (ISO)
tadalafil  (ISO)
tamibarotene  (EXP)
tamoxifen  (EXP,ISO)
Tanshinone I  (EXP,ISO)
taurine  (ISO)
taurochenodeoxycholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (EXP,ISO)
teprenone  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,IEP,ISO)
tetramethylpyrazine  (EXP)
Tetramethylthiourea  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (EXP)
thalidomide  (EXP,ISO)
thapsigargin  (EXP,ISO)
theobromine  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
Thiotepa  (EXP)
thiram  (ISO)
thymol  (EXP,ISO)
thymol sulfate(1-)  (EXP,ISO)
thymoquinone  (EXP,ISO)
thyroxine  (ISO)
tipifarnib  (ISO)
Tiron  (EXP,ISO)
titanium atom  (ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (EXP)
tofacitinib  (EXP)
tolfenamic acid  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (EXP)
torasemide  (ISO)
tranilast  (ISO)
trans-piceid  (ISO)
triadimefon  (ISO)
triamcinolone acetonide  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
trimethyltin  (EXP)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tropisetron  (ISO)
Tubeimoside II  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
udenafil  (ISO)
umbelliferone  (ISO)
uranium atom  (ISO)
urethane  (EXP,ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vancomycin  (EXP)
vemurafenib  (ISO)
verapamil  (ISO)
vildagliptin  (EXP)
vinclozolin  (ISO)
vinorelbine  (ISO)
vitamin D  (EXP,ISO)
vitamin E  (EXP,ISO)
WIN 55212-2  (EXP,ISO)
Y-27632  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (EXP,ISO)
zingerone  (ISO)
ziram  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains  (IDA)
animal organ morphogenesis  (TAS)
animal organ regeneration  (ISO)
aortic valve morphogenesis  (IMP,ISO)
apoptotic process  (ISO)
ATP biosynthetic process  (ISO)
branch elongation involved in mammary gland duct branching  (IMP)
bronchiole development  (IDA,IMP)
canonical Wnt signaling pathway  (IDA)
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment  (TAS)
cell activation  (IDA)
cell morphogenesis  (IDA)
cell population proliferation  (IDA)
cell-cell junction organization  (ISO)
cellular response to acetaldehyde  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to growth factor stimulus  (IDA)
cellular response to hypoxia  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to ionizing radiation  (IMP,ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (IDA,ISO)
cellular response to virus  (IDA)
chondrocyte differentiation  (ISO)
columnar/cuboidal epithelial cell maturation  (IMP)
connective tissue development  (IGI)
defense response  (TAS)
defense response to fungus  (ISO)
digestive tract development  (ISO)
embryonic liver development  (IMP)
endoderm development  (IDA)
epithelial cell proliferation  (IDA)
epithelial to mesenchymal transition  (ISO)
extracellular matrix assembly  (IDA,ISO)
extrinsic apoptotic signaling pathway  (ISO)
face morphogenesis  (IEP)
female pregnancy  (ISO)
frontal suture morphogenesis  (ISO)
gene expression  (IDA,IMP)
germ cell migration  (IDA)
heart development  (IMP)
heart valve morphogenesis  (IMP)
hematopoietic progenitor cell differentiation  (ISO)
hyaluronan catabolic process  (ISO)
inflammatory response  (IMP)
inner ear development  (ISO)
intracellular calcium ion homeostasis  (IMP)
Langerhans cell differentiation  (IMP)
lens fiber cell differentiation  (IMP)
leukocyte proliferation  (TAS)
liver regeneration  (ISO)
lung alveolus development  (IDA)
lymph node development  (IMP)
mammary gland branching involved in thelarche  (IMP)
mammary gland development  (IDA)
membrane protein intracellular domain proteolysis  (ISO)
mononuclear cell proliferation  (IMP)
morphogenesis of a branching structure  (ISO)
muscle cell cellular homeostasis  (IGI)
myelination  (ISO)
negative regulation of biomineral tissue development  (IMP,ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell growth  (IDA,ISO)
negative regulation of cell population proliferation  (ISO,TAS)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (IMP,ISO)
negative regulation of hyaluronan biosynthetic process  (ISO)
negative regulation of interleukin-17 production  (IDA)
negative regulation of macrophage cytokine production  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of myoblast differentiation  (ISO)
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  (ISO)
negative regulation of neuroblast proliferation  (ISO)
negative regulation of ossification  (IDA)
negative regulation of phagocytosis  (ISO)
negative regulation of protein localization to plasma membrane  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of release of sequestered calcium ion into cytosol  (ISO)
negative regulation of skeletal muscle tissue development  (ISO)
negative regulation of T cell activation  (IMP)
negative regulation of T cell proliferation  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA,IGI)
neural tube closure  (IMP)
neural tube development  (IMP)
neuron apoptotic process  (IDA)
Notch signaling pathway  (IDA)
odontoblast differentiation  (IMP)
odontogenesis of dentin-containing tooth  (ISO)
oligodendrocyte development  (IMP)
osteoclast differentiation  (IDA,IGI)
phosphate-containing compound metabolic process  (ISO)
phospholipid homeostasis  (IDA,IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cell division  (IEA)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of chemotaxis  (ISO)
positive regulation of collagen biosynthetic process  (IDA,ISO)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (IDA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of exit from mitosis  (ISO)
positive regulation of extracellular matrix assembly  (IDA)
positive regulation of fibroblast migration  (IMP,ISO)
positive regulation of fibroblast proliferation  (IDA)
positive regulation of gene expression  (IDA,IMP,ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-17 production  (IDA,ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of isotype switching to IgA isotypes  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mesenchymal stem cell proliferation  (ISO)
positive regulation of microglia differentiation  (IMP)
positive regulation of miRNA transcription  (ISO)
positive regulation of mononuclear cell migration  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of odontogenesis  (IDA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of primary miRNA processing  (ISO)
positive regulation of protein dephosphorylation  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein localization to nucleus  (IGI,ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of receptor signaling pathway via STAT  (ISO)
positive regulation of regulatory T cell differentiation  (IMP)
positive regulation of SMAD protein signal transduction  (IDA,ISO)
positive regulation of smooth muscle cell differentiation  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stem cell proliferation  (IDA)
positive regulation of superoxide anion generation  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of vascular permeability  (ISO)
positive regulation of vasculature development  (ISO)
protein export from nucleus  (ISO)
receptor catabolic process  (ISO)
regulation of actin cytoskeleton organization  (IGI)
regulation of branching involved in mammary gland duct morphogenesis  (IGI)
regulation of cartilage development  (IDA)
regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  (TAS)
regulation of cell cycle  (IDA)
regulation of cell population proliferation  (IBA,IDA)
regulation of enamel mineralization  (IMP)
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (IMP)
regulation of gene expression  (IDA)
regulation of interleukin-23 production  (IDA)
regulation of miRNA transcription  (ISO)
regulation of protein import into nucleus  (IDA)
regulation of regulatory T cell differentiation  (IGI)
regulation of sodium ion transport  (IDA)
regulation of striated muscle tissue development  (IDA)
regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulatory T cell differentiation  (IDA,IMP,ISO)
response to cholesterol  (ISO)
response to estradiol  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to immobilization stress  (ISO)
response to laminar fluid shear stress  (ISO)
response to organic cyclic compound  (ISO)
response to progesterone  (ISO)
response to salt  (ISO)
response to vitamin D  (ISO)
response to wounding  (ISO)
response to xenobiotic stimulus  (ISO)
retina vasculature development in camera-type eye  (IDA)
salivary gland morphogenesis  (ISO)
skeletal muscle tissue development  (TAS)
skeletal system development  (TAS)
sprouting angiogenesis  (ISO)
stem cell proliferation  (IDA)
surfactant homeostasis  (IDA,IMP)
T cell activation  (IDA,IMP)
T cell differentiation  (IMP)
T cell homeostasis  (IMP)
T cell proliferation  (IMP)
T-helper 17 cell lineage commitment  (TAS)
tolerance induction to self antigen  (IMP)
transforming growth factor beta receptor signaling pathway  (IBA,IDA,IMP,ISO)
ureteric bud development  (IEP)
vasculogenesis  (IMP)
ventricular cardiac muscle tissue morphogenesis  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal atrial thrombosis  (IAGP)
abnormal bone ossification  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal crypts of Lieberkuhn morphology  (IAGP)
abnormal cutaneous collagen fibril morphology  (IAGP)
abnormal diaphragm morphology  (IAGP)
abnormal embryonic erythropoiesis  (IAGP)
abnormal embryonic hematopoiesis  (IAGP)
abnormal enamel morphology  (IAGP)
abnormal enterocyte morphology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal fluid regulation  (IAGP)
abnormal heart development  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal incisor color  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin level  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal Peyer's patch germinal center morphology  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal regulatory T cell physiology  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
abnormal T-helper 17 cell differentiation  (IAGP)
abnormal tooth attrition  (IAGP)
abnormal tooth mineralization  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal urine potassium level  (IAGP)
abnormal vascular endothelial cell differentiation  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent Langerhans cell  (IAGP)
absent vitelline blood vessels  (IAGP)
ameloblast degeneration  (IAGP)
atrial endocarditis  (IAGP)
brain inflammation  (IAGP)
cachexia  (IAGP)
cecum inflammation  (IAGP)
cleft secondary palate  (IAGP)
colitis  (IAGP)
colonic necrosis  (IAGP)
conjunctivitis  (IAGP)
crypts of Lieberkuhn abscesses  (IAGP)
decreased body height  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased circulating aldosterone level  (IAGP)
decreased circulating angiotensinogen level  (IAGP)
decreased circulating follicle stimulating hormone level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased circulating potassium level  (IAGP)
decreased circulating renin level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased heart rate  (IAGP)
decreased inflammatory response  (IAGP)
decreased Langerhans cell number  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased Peyer's patch number  (IAGP)
decreased retroperitoneal fat pad weight  (IAGP)
decreased spleen weight  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased T-helper 17 cell number  (IAGP)
decreased testes secretion  (IAGP)
decreased thymus weight  (IAGP)
decreased total body fat amount  (IAGP)
decreased urine chloride ion level  (IAGP)
decreased urine osmolality  (IAGP)
decreased urine sodium level  (IAGP)
decreased white fat cell size  (IAGP)
delayed hepatic development  (IAGP)
diaphragmitis  (IAGP)
diarrhea  (IAGP)
disheveled coat  (IAGP)
edema  (IAGP)
embryo tissue necrosis  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enlarged adrenal glands  (IAGP)
enlarged brain ventricles  (IAGP)
enlarged lymph nodes  (IAGP)
excessive folding of visceral yolk sac  (IAGP)
eye inflammation  (IAGP)
failure of chorioallantoic fusion  (IAGP)
failure of copulatory plug deposition  (IAGP)
failure of ejaculation  (IAGP)
gastric necrosis  (IAGP)
gastric ulcer  (IAGP)
heart inflammation  (IAGP)
hepatic necrosis  (IAGP)
hunched posture  (IAGP)
hydrocephaly  (IAGP)
hyperactivity  (IAGP)
hypervolemia  (IAGP)
hypovolemia  (IAGP)
improved glucose tolerance  (IAGP)
increased anal adenocarcinoma incidence  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased basal metabolism  (IAGP)
increased body temperature  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased cell proliferation  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating aldosterone level  (IAGP)
increased circulating angiotensinogen level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating renin level  (IAGP)
increased colon adenocarcinoma incidence  (IAGP)
increased fluid intake  (IAGP)
increased food intake  (IAGP)
increased gastric adenocarcinoma incidence  (IAGP)
increased inflammatory response  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased large intestine adenocarcinoma incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased lung weight  (IAGP)
increased monocyte cell number  (IAGP)
increased rectum adenocarcinoma incidence  (IAGP)
increased regulatory T cell number  (IAGP)
increased stomach tumor incidence  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased susceptibility to kidney reperfusion injury  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased T cell proliferation  (IAGP)
increased T-helper 1 cell number  (IAGP)
increased tumor incidence  (IAGP)
infertility  (IAGP)
interstitial pneumonia  (IAGP)
intracranial hemorrhage  (IAGP)
kyphosis  (IAGP)
lacrimal gland inflammation  (IAGP)
large intestinal inflammation  (IAGP)
lethality at weaning, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
lymph node inflammation  (IAGP)
male infertility  (IAGP)
malocclusion  (IAGP)
misaligned incisors  (IAGP)
multifocal hepatic necrosis  (IAGP)
myocarditis  (IAGP)
myocardium necrosis  (IAGP)
myositis  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
oligozoospermia  (IAGP)
oliguria  (IAGP)
open neural tube  (IAGP)
overexpanded pulmonary alveolus  (IAGP)
pale yolk sac  (IAGP)
pancreas inflammation  (IAGP)
pericarditis  (IAGP)
phlebitis  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
proctitis  (IAGP)
reduced male mating frequency  (IAGP)
renal glomerular immunoglobulin deposits  (IAGP)
renal tubular necrosis  (IAGP)
salivary gland inflammation  (IAGP)
skin inflammation  (IAGP)
small intestinal inflammation  (IAGP)
small seminiferous tubules  (IAGP)
small spleen  (IAGP)
spleen hypoplasia  (IAGP)
stomach inflammation  (IAGP)
thymus hypoplasia  (IAGP)
weight loss  (IAGP)
References

References - curated
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88. Regulatory T cells and TGF-ß1 in clinically localized renal cell carcinoma: Comparison with age-matched healthy controls. Kim CS, etal., Urol Oncol. 2015 Mar;33(3):113.e19-25. doi: 10.1016/j.urolonc.2014.11.004. Epub 2014 Dec 11.
89. Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
90. The TGF-beta1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients. Kim JY, etal., Radiat Oncol. 2009 Nov 27;4:59.
91. Combined effect of IL-10 and TGF-beta1 promoter polymorphisms as a risk factor for aspirin-intolerant asthma and rhinosinusitis. Kim SH, etal., Allergy. 2009 Aug;64(8):1221-5. Epub 2009 Feb 16.
92. The effects of treatment with antibodies to transforming growth factor beta1 and beta2 following spinal cord damage in the adult rat. King VR, etal., Neuroscience. 2004;126(1):173-83.
93. Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease. Kinoshita A, etal., Nat Genet. 2000 Sep;26(1):19-20.
94. Association of transforming growth factor-beta1 gene polymorphisms with myocardial infarction in patients with angiographically proven coronary heart disease. Koch W, etal., Arterioscler Thromb Vasc Biol. 2006 May;26(5):1114-9. Epub 2006 Mar 16.
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PMID:32965772   PMID:32976774   PMID:32980687   PMID:32991667   PMID:33011290   PMID:33063665   PMID:33063836   PMID:33086036   PMID:33087928   PMID:33153107   PMID:33159885   PMID:33168191  
PMID:33175633   PMID:33202935   PMID:33227706   PMID:33367515   PMID:33450323   PMID:33465051   PMID:33510480   PMID:33525359   PMID:33548622   PMID:33571538   PMID:33574570   PMID:33607074  
PMID:33608500   PMID:33641444   PMID:33668543   PMID:33669690   PMID:33759564   PMID:33761981   PMID:33763067   PMID:33804138   PMID:33833129   PMID:33883697   PMID:33936062   PMID:33955458  
PMID:33968067   PMID:34050263   PMID:34072833   PMID:34105268   PMID:34129836   PMID:34150743   PMID:34174537   PMID:34183697   PMID:34184070   PMID:34290057   PMID:34298323   PMID:34337052  
PMID:34348145   PMID:34359856   PMID:34386010   PMID:34391809   PMID:34478025   PMID:34498712   PMID:34504806   PMID:34564693   PMID:34569659   PMID:34583010   PMID:34635982   PMID:34639052  
PMID:34662704   PMID:34707211   PMID:34711823   PMID:34724959   PMID:34769168   PMID:34769245   PMID:34769418   PMID:34774848   PMID:34791098   PMID:34825370   PMID:34845114   PMID:34854257  
PMID:34905511   PMID:34930252   PMID:34948151   PMID:35030969   PMID:35060690   PMID:35069531   PMID:35069535   PMID:35107844   PMID:35137923   PMID:35159350   PMID:35163004   PMID:35165792  
PMID:35166070   PMID:35194136   PMID:35227671   PMID:35232222   PMID:35247391   PMID:35355737   PMID:35358295   PMID:35426372   PMID:35461309   PMID:35506565   PMID:35513229   PMID:35521669  
PMID:35525525   PMID:35584329   PMID:35637489   PMID:35659337   PMID:35704228   PMID:35706000   PMID:35762039   PMID:35852344   PMID:35894043   PMID:35915750   PMID:35928937   PMID:35933783  
PMID:35975910   PMID:35990621   PMID:36001230   PMID:36016413   PMID:36046192   PMID:36064455   PMID:36125128   PMID:36307062   PMID:36307522   PMID:36314682   PMID:36412197   PMID:36414671  
PMID:36414704   PMID:36430328   PMID:36430743   PMID:36435425   PMID:36438502   PMID:36441774   PMID:36463362   PMID:36521562   PMID:36631487   PMID:36683552   PMID:36706696   PMID:36762637  
PMID:36800849   PMID:36917279   PMID:36920729   PMID:37002920   PMID:37037116   PMID:37059312   PMID:37070207   PMID:37156218   PMID:37224650   PMID:37261975   PMID:37263309   PMID:37343276  
PMID:37402364   PMID:37436700   PMID:37486964   PMID:37525933   PMID:37568151   PMID:37569619   PMID:37575268   PMID:37584842   PMID:37612209   PMID:37642183   PMID:37642236   PMID:37643008  
PMID:37672887   PMID:37677924   PMID:37678798   PMID:37683955   PMID:37702745   PMID:37720106   PMID:37756334   PMID:37795611   PMID:37802279   PMID:37814859   PMID:37818607   PMID:37832870  
PMID:37839992   PMID:37865088   PMID:37875957   PMID:37898449   PMID:37909329   PMID:37931653   PMID:37948457   PMID:37964360   PMID:37981065   PMID:38011284   PMID:38014468   PMID:38081108  
PMID:38097742   PMID:38103296   PMID:38113297   PMID:38158021   PMID:38183677   PMID:38218976   PMID:38239077   PMID:38241399   PMID:38246328   PMID:38254097   PMID:38280429   PMID:38284200  
PMID:38407425   PMID:38413821   PMID:38488000  


Genomics

Comparative Map Data
Tgfb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,386,406 - 25,404,503 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,386,427 - 25,404,502 (+)EnsemblGRCm39 Ensembl
GRCm38725,687,002 - 25,705,077 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,687,002 - 25,705,077 (+)EnsemblGRCm38mm10GRCm38
MGSCv37726,472,021 - 26,490,015 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,395,762 - 25,413,756 (+)NCBIMGSCv36mm8
Celera720,295,914 - 20,313,908 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.98NCBI
TGFB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,330,323 - 41,353,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,301,587 - 41,353,922 (-)EnsemblGRCh38hg38GRCh38
GRCh371941,836,228 - 41,859,827 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,528,491 - 46,551,656 (-)NCBINCBI36Build 36hg18NCBI36
Build 341946,528,658 - 46,551,158NCBI
Celera1938,636,964 - 38,659,992 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,268,902 - 38,291,920 (-)NCBIHuRef
CHM1_11941,836,504 - 41,859,495 (-)NCBICHM1_1
T2T-CHM13v2.01944,151,181 - 44,174,790 (-)NCBIT2T-CHM13v2.0
Tgfb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,324,312 - 90,340,627 (+)NCBIGRCr8
mRatBN7.2181,196,532 - 81,212,848 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,196,532 - 81,212,847 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,588,717 - 86,605,032 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0195,140,207 - 95,156,569 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,344,513 - 88,360,828 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,480,875 - 82,497,196 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,480,195 - 82,497,199 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,742,151 - 83,758,472 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,894,705 - 80,911,020 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1180,972,549 - 80,988,992 (+)NCBI
Celera175,636,001 - 75,652,315 (+)NCBICelera
Cytogenetic Map1q21NCBI
Tgfb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555270,652 - 288,441 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955555274,405 - 288,441 (-)NCBIChiLan1.0ChiLan1.0
TGFB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22047,541,048 - 47,564,105 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11949,409,816 - 49,432,810 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,324,009 - 38,347,003 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11946,831,659 - 46,852,973 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,831,659 - 46,852,973 (-)Ensemblpanpan1.1panPan2
B9D2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,621,832 - 112,627,726 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,621,633 - 112,643,885 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,025,951 - 112,032,055 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01113,219,930 - 113,226,035 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,219,701 - 113,241,694 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,781,179 - 112,787,278 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,413,522 - 112,419,614 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,406,803 - 113,412,909 (+)NCBIUU_Cfam_GSD_1.0
Tgfb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,314,010 - 15,330,197 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366613,742,066 - 3,758,272 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366613,742,080 - 3,758,266 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,332,173 - 49,349,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,332,169 - 49,348,642 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,127,027 - 45,141,968 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q11-q21NCBI
TGFB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,651,583 - 35,674,387 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl635,648,677 - 35,674,365 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607313,886,646 - 13,908,666 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907161,569 - 176,605 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624907162,567 - 175,696 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tgfb1
507 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:625
Count of miRNA genes:370
Interacting mature miRNAs:429
Transcripts:ENSMUST00000002678, ENSMUST00000169009, ENSMUST00000171757
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
10045643Skts14_mskin tumor susceptibility 14 (mouse)Not determined72538642725404502Mouse

Markers in Region
Tgfb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37726,489,186 - 26,489,948UniSTSGRCm37
MGSCv37726,473,011 - 26,473,073UniSTSGRCm37
Celera720,313,079 - 20,313,841UniSTS
Celera720,296,904 - 20,296,966UniSTS
Cytogenetic Map7A3UniSTS
cM Map76.5UniSTS
cM Map76.5UniSTS
cM Map76.5UniSTS
PMC307658P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38725,687,961 - 25,688,045UniSTSGRCm38
MGSCv37726,472,980 - 26,473,064UniSTSGRCm37
Celera720,296,873 - 20,296,957UniSTS
Cytogenetic Map7A3UniSTS
cM Map76.5UniSTS
Tgfb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
Tgfb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38725,704,167 - 25,704,929UniSTSGRCm38
MGSCv37726,489,186 - 26,489,948UniSTSGRCm37
Celera720,313,079 - 20,313,841UniSTS
Cytogenetic Map7A3UniSTS
cM Map76.5UniSTS
Tgfb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
cM Map76.5UniSTS
Tgfb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
Tgfb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
Tgfb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
Tgfb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38725,687,992 - 25,688,054UniSTSGRCm38
MGSCv37726,473,011 - 26,473,073UniSTSGRCm37
Celera720,296,904 - 20,296,966UniSTS
Cytogenetic Map7A3UniSTS
Tgfb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000002678   ⟹   ENSMUSP00000002678
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl725,386,427 - 25,404,502 (+)Ensembl
GRCm38.p6 Ensembl725,687,002 - 25,705,077 (+)Ensembl
RefSeq Acc Id: ENSMUST00000169009   ⟹   ENSMUSP00000130413
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl725,388,352 - 25,396,638 (+)Ensembl
GRCm38.p6 Ensembl725,688,927 - 25,697,213 (+)Ensembl
RefSeq Acc Id: ENSMUST00000171757
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl725,391,843 - 25,396,599 (+)Ensembl
GRCm38.p6 Ensembl725,692,418 - 25,697,174 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206348
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl725,388,315 - 25,390,887 (+)Ensembl
GRCm38.p6 Ensembl725,688,890 - 25,691,462 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206584
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl725,387,573 - 25,388,149 (+)Ensembl
GRCm38.p6 Ensembl725,688,148 - 25,688,724 (+)Ensembl
RefSeq Acc Id: NM_011577   ⟹   NP_035707
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,386,427 - 25,404,502 (+)NCBI
GRCm38725,687,002 - 25,705,077 (+)NCBI
MGSCv37726,472,021 - 26,490,015 (+)RGD
Celera720,295,914 - 20,313,908 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036152883   ⟹   XP_036008776
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,386,406 - 25,404,503 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_035707   ⟸   NM_011577
- Peptide Label: preproprotein
- UniProtKB: P04202 (UniProtKB/Swiss-Prot),   Q3UNK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000130413   ⟸   ENSMUST00000169009
RefSeq Acc Id: ENSMUSP00000002678   ⟸   ENSMUST00000002678
RefSeq Acc Id: XP_036008776   ⟸   XM_036152883
- Peptide Label: isoform X1
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04202-F1-model_v2 AlphaFold P04202 1-390 view protein structure

Promoters
RGD ID:6892300
Promoter ID:EPDNEW_M9601
Type:initiation region
Name:Tgfb1_1
Description:Mus musculus transforming growth factor, beta 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9602  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38725,687,003 - 25,687,063EPDNEW
RGD ID:6892302
Promoter ID:EPDNEW_M9602
Type:initiation region
Name:Tgfb1_2
Description:Mus musculus transforming growth factor, beta 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9601  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38725,687,515 - 25,687,575EPDNEW
RGD ID:6842176
Promoter ID:MM_KWN:49468
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000002678
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36726,472,181 - 26,473,192 (+)MPROMDB
RGD ID:6848223
Promoter ID:MM_ACW:43915
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:TGFB1.BSEP07,   TGFB1.DSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36726,473,516 - 26,474,717 (+)MPROMDB
RGD ID:6848875
Promoter ID:MM_TRO:8747
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Liver,   Spleen
Transcripts:MTR006820.7.825.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36726,488,829 - 26,489,329 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98725 AgrOrtholog
Ensembl Genes ENSMUSG00000002603 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000002678 ENTREZGENE
  ENSMUST00000002678.10 UniProtKB/Swiss-Prot
  ENSMUST00000169009.8 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21803 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98725 ENTREZGENE
NCBI Gene 21803 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSFORMING GROWTH FACTOR BETA-1 PROPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB TGFB1 RGD
PhenoGen Tgfb1 PhenoGen
PIRSF TGF-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TGFBETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFBETA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9Q6I6_MOUSE UniProtKB/TrEMBL
  P04202 ENTREZGENE
  Q3UNK5 ENTREZGENE, UniProtKB/TrEMBL
  TGFB1_MOUSE UniProtKB/Swiss-Prot